{"data":[{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2,"idioma_id":4,"titulo":"Evaluation of the antiemetic efficacy of maropitant in dogs medicated with morphine and acepromazine","resumen":"Objective To evaluate whether maropitant(1 mg kg1) injected subcutaneously (SC), administeredsimultaneously or 30 minutes prior to intramuscular(IM) administration of morphine(0.5 mg kg1) and acepromazine (0.05 mg kg1),reduces the incidence of salivation, retching andemesis in dogs.Study design Randomized, controlled, prospectiveclinical trial.Animals Sixty dogs scheduled for an ovariohysterectomyas part of a population control program.Methods Dogs were randomly allocated to beadministered maropitant (1 mg kg1) SC simultaneously(group M0) or 30 minutes prior to (groupM30) administration of morphine (0.5 mg kg1)and acepromazine (0.05 mg kg1) IM. A controlgroup was administered normal saline (C) at T-30and T0. Dogs were observed for 30 minutes aftermorphine?acepromazine administration. The occurrenceof vomiting, retching and salivation wererecorded, as well as the time to first emesis and thenumber of emetic events per dog.Results The occurrence of salivation was not differentbetween the groups. Retching and vomitingoccurred significantly less frequently in M30 than inthe other two groups (p < 0.02). The number ofemetic events was also significantly less for M30than for the other two groups (p = 0.01). Whenemesis occurred, the time to the first emetic eventwas similar among the groups.Conclusions and clinical relevance Maropitant(1 mg kg1) SC reduced the frequency of morphine-induced emesis by as much as 70% whenadministered 30 minutes in advance. Simultaneousadministration of maropitant and morphine?acepromazineproduced no measurable effect on thefrequency of retching or vomiting.","palabras_clave":"Maropitant|Morphine|Acepromacine|Vomiting|Dogs"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3,"idioma_id":5,"titulo":"Economía social y acción colectiva.  El caso de la economía barilochense de pequeña y micro-escala","resumen":"El desarrollo es un proceso endógeno de creación de riqueza y mejores condiciones de vida de la población, donde los procesos de acción colectiva entre actores públicos y privados de un territorio y sus mecanismos institucionales son un factor clave. El trabajo articula enfoques teóricos del desarrollo local, acción colectiva y economía social. La hipótesis es que, frente a situaciones de catástrofe, los esfuerzos y compromisos colectivos, como manifestaciones de capital social, podrían potenciarse y convertirse en estrategias de superación de la crisis y de desarrollo. Se analizan los procesos asociativos entre microemprendedores de la ciudad turística de Bariloche (Patagonia Norte, Argentina) que surgieron o profundizaron con la emergencia volcánica de junio-2011. La evidencia empírica muestra que la crisis (factor exógeno) expuso la vulnerabilidad e invisibilizacion del sector dando luz a nuevas oportunidades. Promover y fortalecer el capital social (factor endógeno) resulta estratégico para pensar políticas de desarrollo local.","palabras_clave":"CAPITAL SOCIAL|EMPRENDEDORES|DESARROLLO LOCAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":4,"idioma_id":4,"titulo":"Prosopis  alba  exudate  gum  as  excipient  for  improving fish  oil  stability  in  alginate?chitosan beads","resumen":"The aim of the present work was to employ an exudate gum obtained from a South American wild tree (Prosopis alba), as wall material component to enhance the oxidative stability of fish oil encapsulated in alginate?chitosan beads. For this purpose, beads were vacuum-dried and stored under controlled conditions.Oxidation products, fatty acid profiles and lipid health indices were measured during storage. Alginate?chitosan interactions and the effect of gum were manifested in the FT-IR spectra. The inclusion of the gum in the gelation media allowed decreasing the oxidative damage during storage in comparison to the free oil and alginate?chitosan beads. The gum also improved wall material properties, providing higher oil retention during the drying step and subsequent storage. Fatty acids quality and lipid health indices were widely preserved in beads containing the gum. Present results showed a positive influence of the gum on oil encapsulation and stability, being the main mechanism attributed to a physical barrier effect.","palabras_clave":"PROSOPIS ALBA|EXUDATE GUM|DHA|IONIC GELATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":7,"idioma_id":4,"titulo":"Annexin A2 and S100A10 in the mammalian oviduct","resumen":"In many mammals upon entryon the female reproductive tract a subpopulation of sperm is stored in theoviduct forming a&nbsp;functional reservoir. In the oviducts of pig and cow, AnnexinA2 (AnxA2) has been linked to the binding of sperm. This protein may exist as a monomer or boundto S100A10, and both forms are associatedwith different biological functions. S100A10 has not yet beenreported in the oviduct. The objective of this work was to analyze for thepresence of S100A10 in the oviduct and advance in the study of AnxA2 andS100A10 in this organ. This work shows the presence of both proteins, AnxA2 andS100A10, in the oviduct of human, pig, cow, cat, dog and rabbit. At least in pig,AnxA2 is found devoid of S100A10 in the outer surface of the apical plasmamembrane of oviductal epithelial cells, indicating it binds to sperm as a monomer or in association with proteins differentfrom S100A10. In the apical cytoplasm of pig oviductal epithelial cells, AnxA2 isassociated to S100A10. Inprimary culture of porcine oviductal cells, the expression of ANXA2 is increased byprogesterone, while the expression of S100A10 is increased byprogesterone and estradiol. Thewidespread detection of both proteins in the oviduct of mammals indicates a probable conserved function in this organ. In summary, S100A10and AnxA2 are widespread in the mammalian oviduct, but AnxA2 would bind sperm invivo devoid of S100A10 and may be related to reservoir formation. &nbsp;","palabras_clave":"oviducto|anexina A2|S100A10|reservorio"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":9,"idioma_id":4,"titulo":"Mechanochemical synthesis of MnZn ferrite nanoparticles suitable for biocompatible ferrofluids","resumen":"Mn0.4Zn0.6Fe2O4 nanoparticles (NPs) were synthesized by the mechanochemical method, starting from elemental oxides. Structural and magnetic properties of the NPs were investigated by X ray diffraction (XRD), vibrating sample magnetometry (VSM) and both scanning and transmission electron microscopy (SEM and TEM). XRD measurements show that MnZn ferrite is already present after 15&nbsp;min of milling. After milling for 120&nbsp;min, the resulting powder is almost completely single-phase without the need of any thermal treatment. Magnetization curves for samples with different milling times show saturation magnetizations ranging from 12.2&nbsp;emu\/g&nbsp;?after 15&nbsp;min to 50.3&nbsp;emu\/g ?after 120&nbsp;min. Coercive field and remanent magnetization are negligible for all samples, in agreement with a superparamagnetic behavior. NPs with mean size of 8&nbsp;nm were separated by centrifugation and were coated with chitosan for the preparation of a ferrofluid, which showed good stability for 12&nbsp;h. The Intrinsic Loss Parameter (ILP) of this fluid indicates that the mechanochemical method can be a good alternative for the synthesis of the usual Fe-oxides ferrofluids used in hyperthermia.","palabras_clave":"MECHANOCHEMISTRY|MNZN NANOPARTICLES|BIOCOMPATIBLE FERROFLUIDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10,"idioma_id":4,"titulo":"Exchanged lanthanum in InHMOR and its impact on the catalytic performance of InHMOR. Spectroscopic, volumetric and microscopic studies","resumen":"The incorporation of lanthanum by ion exchange into InHMordenite was studied in order to investigate the modification of the physicochemical properties of the InHM catalysts. The prepared solids, LaInHM and InHM, were treated under rigorous reaction conditions, i.e. 25 h of TOS with addition of 10% of water and 500 °C. The structural changes of the catalysts were followed by spectroscopic, volumetric and microscopic studies. The presence of lanthanum in the InHM acts like a protection for the zeolite structure avoiding the formation of EFAl species, but the alteration of the indium environment into the matrix leads to a reduction of the catalytic yield of the InHM catalyst. In fact the XPS results revealed that the concentration of the indium active sites (InO)+ in LaInHM is lower than in the InHM catalyst, while the remaining indium species interact strongly with Lanthanum. After the reaction, a decrease of In active site in the LaInHM catalyst was observed, suggesting a closer interaction In-La which was later corroborated by TEM microscopy. On the other hand, a steric factor between the side channels of the mordenite and the hydrated cation of La during the exchange process locates lanthanum in outer position, with the consequent loss of pore volume and area specific. The lanthanum exchanged ions protect the deactivation process by structure collapse, but negatively affect the activity of the InHM catalyst.","palabras_clave":"INDIUM-MORDENITE;| NOX-SCR.| LANTHANUM-MORDENITE| ZEOLITE HYDROTHERMAL STABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":11,"idioma_id":4,"titulo":"Photochemistry of imidazolium cations. Water addition to methylimidazolium ring induced by UV radiation in aqueous solution","resumen":"The UV-C induced photoaddition of water to N-alkyl-N´-methylimidazolium cations was studied. The main photoreaction products exhibit chemical additions of a proton and a hydroxyl group to either positions 4 or 5 of the imidazolium ring. For unsymmetrical imidazolium cations, two positional isomers were obtained as products. In these cases, the most abundant isomer is the one in which the hydroxyl group adds at the side of the ring having the longer alkyl substituent. Experiments performed in D2O solutions reveal that the additions of proton and hydroxyl group never take place at the same carbon atom, in a reaction that produces equal amounts of diastereoisomers. Moreover, the formation of diastereoisomers at equal proportions suggests that the reaction proceeds in an unconcerted fashion.","palabras_clave":"Imidazolium|Ionic liquid|photoaddition|UV-C reaction|Water addition"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":13,"idioma_id":4,"titulo":"Soybean fruit development and set at the node level under combined photoperiod and radiation conditions","resumen":"In soybean, long days during post-flowering increase seed number. This positive photoperiodic effect on seed numberhas been previously associated with increments in the amount of radiation accumulated during the crop cyclebecause long days extend the duration of the crop cycle. However, evidence of intra-nodal processes independent ofthe availability of assimilates suggests that photoperiodic effects at the node level might also contribute to pod set.This work aims to identify the main mechanisms responsible for the increase in pod number per node in responseto long days; including the dynamics of flowering, pod development, growth and set at the node level. Long daysincreased pods per node on the main stems, by increasing pods on lateral racemes (usually dominated positions)at some main stem nodes. Long days lengthened the flowering period and thereby increased the number of openedflowers on lateral racemes. The flowering period was prolonged under long days because effective seed filling wasdelayed on primary racemes (dominant positions). Long days also delayed the development of flowers into pods withfilling seeds, delaying the initiation of pod elongation without modifying pod elongation rate. The embryo developmentmatched the external pod length irrespective of the pod?s chronological age. These results suggest that long daysduring post-flowering enhance pod number per node through a relief of the competition between pods of differenthierarchy within the node. The photoperiodic effect on the development of dominant pods, delaying their elongationand therefore postponing their active growth, extends flowering and allows pod set at positions that are usuallydominated.","palabras_clave":"Soybean|photoperiod"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":14,"idioma_id":4,"titulo":"Cover crops in the agricultural systems of the Argentine Pampas","resumen":"Cover crops in the agricultural systems of the Argentine Pampas","palabras_clave":"COVER CROPS|Pampas Region|NITRATES|Fallow"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":15,"idioma_id":4,"titulo":"Galectin-1 controls the proliferation and migration of liver sinusoidal endothelial cells and their interaction with hepatocarcinoma cells","resumen":"Galectin-1 (Gal1), a &#946;-galactoside-binding protein abundantly expressed in hepatocellular carcinoma (HCC), promotes epithelial-mesenchymal transition (EMT) and correlates with HCC growth, invasiveness and metastasis. During the early stages of HCC, transforming growth factor &#946;1 (TGF-&#946;1) acts as a tumor suppressor; however in advanced stages, HCC cells lose their cytostatic response to TGF-&#946;1 and undergo EMT. Here, we investigated the role of Gal1 on liver endothelial cell biology, and the contribution and interplay between Gal1 and TGF-&#946;1 in HCC progression. By Western blot and immunofluorescence, we analyzed Gal1 expression, secretion and localization in HepG2 and HuH-7 human HCC cells, and in SK-HEP-1 human liver sinusoidal endothelial cells (SECs). We used loss-of-function and gain-of-function experiments to down- or up-regulate Gal1 expression, respectively, in HepG2 cells. We cultured SK-HEP-1 cells with conditioned media from HCC cells secreting different levels of Gal1, and demonstrated that tumorigenic hepatocyte-derived Gal1 induced its own expression in SECs. MTS colorimetric and scratch-wound assays revealed that secretion of Gal1 by HCC cells induced SEC proliferation and migration, respectively. Interestingly, by fluorescence microscopy we demonstrated that Gal1 promoted glycan-dependent heterotypic adhesion of HepG2 cells to SK-HEP-1 SECs. Furthermore, TGF-&#946;1 induced Gal1 expression and secretion by HCC cells, and promoted HepG2 cell adhesion to SK-HEP-1 SECs through a Gal1 expression-dependent mechanism. Notably, Gal1 modulated HepG2 cell proliferation and sensitivity to TGF-&#946;1-induced growth inhibition. Our results suggest that Gal1 and TGF-&#946;1 might function coordinately within the HCC microenvironment to regulate tumor growth, invasion, metastasis and angiogenesis.","palabras_clave":"GALECTIN-1|HEPATOCELLULAR CARCINOMA|ENDOTHELIAL CELL|TGF-BETA1"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17,"idioma_id":4,"titulo":"RT-PCR and sequence analysis of the full-length fusion protein of Canine Distemper Virus from domestic dogs","resumen":"During 2007-2014, 84 out of 236 (35.6 %) samples from domestic dogs submitted to our laboratory for diagnostic purposes were positive for Canine Distemper Virus (CDV), as analyzed by RT-PCR amplification of a fragment of the nucleoprotein gene. Fifty-nine of them (70.2 %) were from dogs that had been vaccinated against CDV. The full-length gene encoding the Fusion (F) protein of fifteen isolates was sequenced and compared with that of those of other CDVs, including wild-type and vaccine strains. Phylogenetic analysis using the F gene full-length sequences grouped all the Argentinean CDV strains in the SA2 clade. Sequence identity with the Onderstepoort vaccine strain was 89.0?90.6 %, and the highest divergence was found in the 135 amino acids corresponding to the F protein signal-peptide, Fsp (64.4-66.7 % identity). In contrast, this region was highly conserved among the local strains (94.1-100 % identity). One extra putative N-glycosylation site was identified in the F gene of CDV Argentinean strains with respect to the vaccine strain. The present report is the first to analyze full-length F protein sequences of CDV strains circulating in Argentina, and contributes to the knowledge of molecular epidemiology of CDV, which may help in understanding future disease outbreaks.","palabras_clave":"CANINE DISTEMPER VIRUS|F GENE|RT PCR|PHYLOGENETIC ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19,"idioma_id":5,"titulo":"Correlación entre los niveles de fosfatasa alcalina salival y la profundidad de la bolsa periodontal","resumen":"Introducción: las enzimas salivales del huésped se han propuesto como biomarcadores de diagnóstico del estado periodontal. La concentración de la fosfatasa alcalina salival (FAL) se ha asociado con la enfermedad periodontal (EP). Objetivo: el propósito  de este estudio fue determinar la posible relación entre los niveles de FAL en la saliva y las profundidades de sondaje. Materiales y Métodos: un total de 90 pacientes, sistémicamente sanos y con periodontitis, se dividieron en dos grupos: G1, 45 pacientes con bolsas periodontales de 4-5 mm de profundidad y G2, 45 pacientes con 6 o más mm de profundidad. Los niveles de ALP (UI\/l) en la saliva se evaluaron mediante un espectrofotómetro a 520 nm. Resultados: la concentración media de ALP salival fue mayor en el G1 en comparación con el G2 (p > 0,05). La prueba de correlación de Pearson mostró relación significativa entre las concentraciones de ALP salival y la profundidad de sondaje (p > 0,05). Conclusión: las determinaciones de ALP salival pueden llegar a ser prácticas y fiables para la detección de la actividad y gravedad de la EP.","palabras_clave":"FOSFATASA ALCALINA|ENFERMEDAD PERIODONTAL|SALIVA|BOLSAS PERIODONTALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":21,"idioma_id":4,"titulo":"A contribution of beef to human health: a review of the role of the animal production systems","resumen":"Meat andmeat products constitute important source of protein, fat, and several functional compounds.Although beef consumptionmay implicate possible negative impacts on human health, its consumption can also contribute to human health. Quality traits ofbeef, as well as its nutritional properties, depend on animal genetics, feeding, livestock practices, and post mortem procedures.Available data show that emerging beef production systems are able to improve both, quality and nutritional traits of beef in asustainable way. In this context, Argentina?s actions are aimed at maximising beef beneficial effects and minimising its negativeimpact on human health, in a way of contributing to global food security.","palabras_clave":"BEEF PRODUCTION|MEAT QUALITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":22,"idioma_id":4,"titulo":"Studies of Acute and Chronic Toxicity of Commercial Herbicides with Glyphosate against  Danio rerio","resumen":"Glyphosate or N-(phosphonomethyl) glycine is a broad spectrum non-selective systemic herbicide, used to kill weeds, mainly in soybean crops. Nowadays there are many controversies about the intensive use of these herbicides due to the potential environmental impact and the effects on human health. The environmental impacts of commercial Glyphosate formulation Roundup were assessed by evaluation of acute and chronic toxicity of Danio rerio fish. The effects of glyphosate commercial formulations and glyphosate isopropylamine salt solutions were evaluated in different steps. First the lethal doses of Roundup herbicide toward the experimental models were determined. Subsequently the specie was exposed to sublethal concentrations of both, the commercial preparations and pure glyphosate salt in order to evaluate the chronic toxicity. Acute toxicity was assessed by calculating the mortality indexes and chronic toxicity by measuring several biochemical parameters such as the activity of marker enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT) and acetylcholinesterase (AchE). The registers of histological alterations in liver tissue sections were also considered in this study. Commercial herbicides produce mortality of D. rerio and sublethal doses of these herbicides and the salt of the pure compound produce effects of chronic toxicity at the liver and muscle level; such are enough causes to limit the potential survival of these organisms in the medium.","palabras_clave":"ACUTE TOXICITY|CHRONIC TOXICITY|FISH|GLYPHOSATE|DANIO RERIO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":23,"idioma_id":4,"titulo":"Influence of the harvesting procedure and extracting process on the antioxidant  capacity of ethanolic propolis extracts","resumen":"Under article 1339 of the Argentine Food Code, food containing propolis is considered dietary. Propolis is a complex mixture of over 200 compounds, mainly polyphenols, which are classified as bioactive and have important biological effects. Its relative concentration depends on the origin of the sample, and therefore the relationship between flavonoids and biological effects reveals interest to assess those constituents. Therefore, propolis may be suitable for use in the formulation of functional foods or potentiate the biological effects of other food constituents, combining and acting together. Propolis samples were obtained by scraping and trapping. Extractions were also carried out with dissolutions in 70, 80, 85% ethanol at room temperature, by mixing and stirring; and by the Soxhlet method. The concentration of the resulting extracts was achieved at 30°C and 40°C. In all cases the antioxidant capacity was measured by the Trolox method, the efficiency of the extraction and the concentration of the total flavonoids and phenols were calculated. The temperature which is used to concentrate them has influence on their antioxidant power, the latter being lower at lower temperature. Soxhlet extraction decreases antioxidant capacity as well as content of flavonoids and phenolic compounds. The resulting extracts showed good antioxidant capacity and didn´t show direct relationship with ethanol concentration","palabras_clave":"Propolis extract|antioxidant capacity|flavonoids"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":24,"idioma_id":4,"titulo":"The Trypanosoma cruzi protein TcHTE is critical for heme uptake","resumen":"Trypanosoma cruzi, the etiological agent of Chagas´ disease, presents nutritional requirements for several metabolites. It requires heme for the biosynthesis of several heme-proteins involved in essential metabolic pathways like mitochondrial cytochromes and respiratory complexes, as well as enzymes involved in the biosynthesis of sterols and unsaturated fatty acids. However, this parasite lacks a complete route for its synthesis. In view of these facts, T. cruzi has to incorporate heme from the environment during its life cycle. In other words, their hosts must supply the heme for heme-protein synthesis. Although the acquisition of heme is a fundamental issue for the parasite?s replication and survival, how this cofactor is imported and distributed is poorly understood. In this work, we used different fluorescent heme analogs to explore heme uptake along the different life-cycle stages of T. cruzi, showing that this parasite imports it during its replicative stages: the epimastigote in the insect vector and the intracellular amastigote in the mammalian host. Also, we identified and characterized a T. cruzi protein (TcHTE) with 55% of sequence similarity to LHR1 (protein involved in L. amazonensis heme transport), which is located in the flagellar pocket, where the transport of nutrients proceeds in trypanosomatids. We postulate TcHTE as a protein involved in improving the efficiency of the heme uptake or trafficking in T. cruzi.","palabras_clave":"HEME|TRYPANOSOMA CRUZI|TRANSPORT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":25,"idioma_id":4,"titulo":"A NON-PERMUTATION FLOW-SHOP SCHEDULING PROBLEM WITH LOT STREAMING: A MATHEMATICAL MODEL","resumen":"In this paper we investigate the use of lot streaming in non-permutation flowshop schedulingproblems. The objective is to minimize the makespan subject to the standard flowshopconstraints, but where it is now permitted to reorder jobs between machines. In addition, thejobs can be divided into manageable sublots, a strategy known as lot streaming. Computationalexperiments show that lot streaming reduces the makespan up to 43% for a wide range ofinstances when compared to the case in which no job splitting is applied. The benefits grow asthe number of stages in the production process increases but reach a limit. Beyond a certainpoint, the division of jobs into additional sublots does not improve the solution.","palabras_clave":"Non-Permutation Flowshop|Scheduling|Lot Streaming|Makespan"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":26,"idioma_id":4,"titulo":"Revised stratigraphic framework of the Cretaceous in the Bajo Grande area (Argentinean Patagonia) inferred from new U-Pb ages and palynology","resumen":"The revision of the stratigraphy of the Cerro Bayo in the Bajo Grande area (Argentinean Patagonia) and the new 206Pb\/238U age of 116.85±0.26 Ma allow constraining the timing of the Baqueró flora, one of the most abundant Aptian floras on the southern Gondwana.This flora,preserved in the Baqueró Group, represents an extinct biome that flourished ca. 118 my ago and was affected by increasing regional volcanism during the subsequent four millions years.The outcrops of the Cerro Bayo are characterized by fluvio-lacustrine deposits divided in three facies associations that include ninelithofacies. The first palynological record for the locality confirms the correlation of the lower part of the outcrops with the Anfiteatro de Ticó Formation (oldest unit of the Baqueró Group). The new radiometric age and stratigraphy support the recognition of the Bajo Tigre Formation (middle unit of the Baqueró Group) in the area and aged the earliest stage in the angiosperm diversification in southern South América.","palabras_clave":"CRETACEOUS|APTIAN|PALYNOLOGY|GEOCHRONOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":28,"idioma_id":5,"titulo":"Confianza institucional y social: una relación insoslayable","resumen":"Las instituciones son las encargadas de promover, regular y garantizar la acción social coordinada entre los ciudadanos. Desde hace varias décadas la confianza institucional ha ido descendiendo. Esto genera un problema importante, ya que la confianza institucional es necesaria para la formación instituciones. Dentro de las consecuencias negativas que esto trae aparejado, se halla que la baja confianza institucional se asocia con la baja confianza social. El objetivo de este trabajo es analizar la relación entre la confianza institucional y la confianza social en el contexto argentino, los niveles de confianza, y la relación entre la confianza y eficacia institucional. Para ello se elaboró un cuestionario auto-administrado que se aplicó a 316 estudiantes universitarios de cuatro universidades públicas y privadas de la Ciudad Autónoma de Buenos Aires. Los resultados indican que los participantes tienen una baja confianza institucional y social, que hay una relación entre la confianza institucional y la confianza social general, y finalmente, que la confianza institucional es influida por la percepción de eficacia de las instituciones.","palabras_clave":"ARGENTINA|CONFIANZA INSTITUCIONAL|CONFIANZA SOCIAL|EFICACIA INSTITUCIONAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":29,"idioma_id":4,"titulo":"Archosauriform remains from the Late Triassic of San Luis province, Argentina, Quebrada del Barro Formation, MarayeseEl Carrizal Basin","resumen":"Here we present archosauriform remains from ?Abra de los Colorados?, a fossiliferous locality at Sierra de Guayaguas, NW San Luis Province. Two fossiliferous levels were identified in outcrops of the Quebrada del Barro Formation (Norian), which represent the southernmost outcrops of the Marayes?El Carrizal Basin. These levels are composed by massive muddy lithofacies, interpreted as floodplain deposits. The specimens consist of one incomplete maxilla (MIC-V718), one caudal vertebra (MIC-V719), one metatarsal (MIC-V720) and one indeterminate appendicular bone (MIC-V721). The materials can be assigned to Archosauriformes but the fragmentary nature and lack of unambiguous synapomorphies preclude a more precise taxomic assignment. The maxilla is remarkably large and robust and represents the posterior process. It preserved one partially erupted tooth with ziphodont morphology. This bone shows some anatomical traits and size match with ?rauisuchians? and theropods. MIC-V719 corresponds to a proximal caudal vertebra. It has a high centrum, a ventral longitudinal furrow, expanded articular processes for the chevrons, a posteriorly displaced diapophysis located below the level of the prezygapophyses, and short prezygapophyses. This vertebra would be from an indeterminate archosauriform. MIC-V720 presents a cylindrical diaphysis, with a well-developed distal trochlea, which present resemblances with metatarsals of theropods, pseudosuchians, and silesaurids, although the size matches better with theropods. MIC-V721 has a slender diaphysis and a convex triangular articular surface, and corresponds to an indeterminate archosauriform. Despite being fragmentary, these materials indicate the presence of a diverse archosauriforms association from Late Triassic beds of San Luis. Thus, they add to the faunal assemblage recently reported from this basin at San Juan Province, which is much rich and diverse than the coeval paleofauna well known from Los Colorados Formation in the Ischigualasto?Villa Union Basin.","palabras_clave":"ARCHOSAURIFORMES|MARAYES EL CARRIZAL BASYN|QUEBRADA DEL BARRO FORMATION|LATE TRIASSIC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":30,"idioma_id":4,"titulo":"Elemental Analysis of Amaranth, Chia, Sesame, Linen, and Quinoa Seeds by ICP-OES: Assessment of Classification by Chemometrics","resumen":"Received: 17 March 2015 \/Accepted: 1 June 2015# Springer Science+Business Media New York 2015Abstract In this work, 26 elements (Ag, Al, As, B, Ba, Ca,Cd, Co, Cr, Cs, Cu, Ga, Fe, K, Mg, Mn, Na, P, Pb, Rb, Se, Si,Sr, Ti, V, and Zn) were analyzed by inductively coupled plasmaoptical emission spectroscopy (ICP-OES) in seed samples:amaranth, chia, sesame, linen, and quinoa. Elemental analysisshowed the presence of toxic elements (As, Cd, and Pb), aswell as high mineral content (Fe, Na, P, K, and Mg): Theconcentrations of toxic elements were below the permissiblelimits by the WHO. Chemometrics was performed by clusteranalysis (CA), principal component analysis (PCA), and partialleast squares discriminant analysis (PLS-DA). In all cases,a correct classification of each type of seed was obtained. Thecombination of elemental analysis (major, minor, and toxicelements) and chemometrics was useful to determine nutritionalquality in the studied seeds, as well as to classify themaccording to the botanical origin. For that, this method can beuseful for the analysis of raw material as quality control infood factories and government control labs.","palabras_clave":"Amaranth, Chia, Sesame, Linen, and Quinoa Seeds|ICP-OES:|Chemometrics|Classification"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":31,"idioma_id":4,"titulo":"Prolactin, Androstenedione and IGF1 Serum Concentrations During Induced Follicular Growth by eCG Administration in the Bitch","resumen":"The estrus cycle in the domestic bitch, a monoestrous species, differs considerably from that of other veterinary domestic animals species. In the bitch the combined use of eCG and hCG is effective to induce estrus predictably and safely (Stornelli and al 2012). Although several studies were done to describe the hormonal changes during the canine estrus cycle, to our knowledge none was done to describe the hormonal changes during induced follicular growth after the administration of eCG. The aim of this work was to study prolactin (PRL), insulin-like growth factor (IGF1) and androstenedione (ANDR) serum concentrations during follicular growth induced by a single dose of eCG administered to late anestrous bitches. PRL and ANDR concentrations were lower before than after eCG TRT (before eCG vs proestrus, estrus and diestrus; 4.3± 1.8ng\/mL vs. 6.5±1.6 ng\/mL, P0.53). Additionally, PRL concentrations were similar before estrus compared to during estrus and diestrus (6.9±1.7 ng\/mL, P>0.19). Furthermore, IGF1 concentrations were higher before and during estrus compared to first day of diestrus (286.1±29.8vs. 200.4±29.2 ng\/mL, P<0.01). On the contrary, ANDR concentrations were lower before and during estrus compared to first day of diestrus (0.35±0.17 ng\/mL and 0.38±0.15 vs.0.68±0.17 ng\/mL, P<0.05). These results show that treatment with a single injection of 50 IU \/kg of eCG in late anestrous bitches successfully induced changes in follicular growth which were paralleled with changes in PRL, IGF1 and ANDR serum concentration similar to those occurring during a normally occurring estrous cycle. In addition, our results suggest that IGF1 in the bitch could play an important role in ovarian folliculogenesis.","palabras_clave":"PERRA|ESTRO|eCG"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":33,"idioma_id":4,"titulo":"Facile synthesis of cobalt ferrite nanotubes using bacterial nanocellulose as template","resumen":"A facile method for the preparation of cobalt ferrite nanotubes by use of bacterial cellulose nanoribbons as a template is described. The proposed method relays on a simple coprecipitation operation, which is a technique extensively used for the synthesis of nanoparticles (either isolated or as aggregates) but not for the synthesis of nanotubes. The precursors employed in the synthesis are chlorides, and the procedure is carried out at low temperature (90&nbsp;°C). By the method proposed a homogeneous distribution of cobalt ferrite nanotubes with an average diameter of 217&nbsp;nm in the bacterial nanocellulose (BC) aerogel (3%) was obtained. The obtained nanotubes are formed by 26?102&nbsp;nm cobalt ferrite clusters of cobalt ferrite nanoparticles with diameters in the 9?13&nbsp;nm interval. The nanoparticles that form the nanotubes showed to have a certain crystalline disorder, which could be attributed in a greater extent to the small crystallite size, and, in a lesser extent, to microstrains existing in the crystalline lattice. The BC-templated-CoFe2O4 nanotubes exhibited magnetic behavior at room temperature. The magnetic properties showed to be influenced by a fraction of nanoparticles in superparamagnetic state.","palabras_clave":"BACTERIAL NANOCELLULOSE|COBALT FERRITE|NANOTUBES|BIOTEMPLATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":35,"idioma_id":4,"titulo":"Topical amphotericin B in ultradeformable liposomes: formulation, skin penetration study, antifungal and antileishmanial activity in vitro","resumen":"Aiming to improve the topical delivery of AmB to treat cutaneous fungal infections and leishmaniasis, ultradeformable liposomes containing amphotericin B (AmB-UDL) were prepared, and structural and functional characterized. The effect of different edge activators, phospholipid and AmB concentration, and phospholipid to edge activator ratio on liposomal deformability, as well as on AmB liposomal content, was tested. Liposomes having Tween 80 as edge activator resulted of maximal deformability and AmB\/phospholipid ratio. These consisted of AmB-UDL of 107 ± 8 nm diameter, 0.078-polydispersity index and &#8722;3 ± 0.2 mV Z potential, exhibiting monomeric AmB encapsulated in the bilayer at a 75% encapsulation efficiency. After its cytotoxicity on keratinocytes (HaCaT cells) and macrophages (J774 cells) was determined, the in vitro antifungal activity of AmB-UDL was assayed. It was found that fungal strains (albicans and non-albicans Candida ATCC strains and clinical isolates of C. albicans) were more sensitive to AmB-UDL than mammal cells. Minimum inhibitory concentration values for AmB-UDL were 5?24 and 24?50 times lower than IC50 for J774 and HaCaT cells, respectively. AmB-UDL at 1.25 &#956;g\/ml also displayed 100 and 75% anti- Leishmania braziliensis promastigote and amastigote activity, respectively. Finally, upon 1 h of non-occlusive incubation, the total accumulation of AmB in human skin was 40 times higher when applied as AmB-UDL than as AmBisome. AmB-UDL provided a profound AmB penetration toward deep epithelial layers, achieved without classical permeation enhancers. Because of that, topical treatments of cutaneous fungal infection and leishmaniasis with AmB-UDL may be regarded of potential of clinical significance.","palabras_clave":"FLEXIBLE LIPOSOMES|SKIN DELIVERY|CANDIDA spp|LEISHMANIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":37,"idioma_id":4,"titulo":"Active sesquiterpene lactones against Leishmania amazonensis and Leishmania braziliensis","resumen":"Abstract  Seventeen sesquiterpene lactones (SLs) isolated from five species of the tribe Vernonieae were evaluated for their in vitro activity against promastigotes of Leishmania amazonensis and L. braziliensis. The most active compounds against L. braziliensis were 16 and 17 (IC50 values 1.45 and 1.34 µM respectively), followed by compound 15 with IC50 value of 1.60 µM against L. amazonensis. This is the first report of the known germacradiendiolides 16 and 17 from Elephantopus mollis. Additionally, several molecular descriptors were obtained for the SLs by means of computational methods. Descriptors related to hydrophobicity and polarizability of the molecules showed the best correlation with the antiprotozoal activity, suggesting that the primary mode of action of the evaluated SLs could be related to its interaction with membranes of parasite. The activity data of compounds 1-17 assayed against Leishmania parasites is reported here for the first time.","palabras_clave":"Vernonieae|sesquiterpene lactones|antileishmanial activity|Leishmania amazonensis|Leishmania braziliensis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":38,"idioma_id":4,"titulo":"Selective hydrogenation of cinnamaldehyde in supercritical CO2 over  Me-CeO2 (Me = Cu, Pt, Au): insight of the role of Me-Ce interaction","resumen":"The performance of platinum, gold and copper catalysts with low (0.1 wt%) and high (2-3.8 wt%) metal loadings, supported on ceria with high surface area (240 m2\/g), are contrasted in the hydrogenation of cinnamaldehyde. Two reaction solvents were tested: single-phase near critical CO2+isopropanol mixture and supercritical CO2, both performed at 323 K and 20 MPa. Exceptionally high activities were measured under supercritical CO2 for low loaded platinum and gold catalysts, while selectivities to cinnamyl alcohol were in the range of 80 to 90 %. The same trends, but in a lower degree, were observed for the corresponding copper sample. The catalytic pattern in near critical condition was between the ones corresponding to supercritical CO2 and classical gas-liquid, as previously reported for platinum based catalysts.The enhancement of the selectivity can be explained by a combined effect of the supercritical CO2-substrate interaction and by the adsorption of cinnamaldehyde on sites of the metal-ceria interface. Based on the TPR and XPS characterizations, it was concluded that the rise of the activity would be due to a major concentration of these active sites in the low loaded samples.","palabras_clave":"CERIA|LOW METAL LOADINGS|GOLD|COPPER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":39,"idioma_id":5,"titulo":"Nuevo abordaje para el cálculo del Indice de performance miocárdico (IPM): el Doppler tisular pulsado en perros beagles","resumen":"El índice de performance miocárdica (IPM) o índice de Tei (ITei) evalúa la función sistodiastólica ventricular global (derecha o izquierda). La sencillez de su determinación, así como la reproducibilidad de las mediciones lo convierten en una técnica ampliamente utilizada en cardiología veterinaria. En el presente estudio se obtuvo el mencionado índice a través de la técnica Doppler tisular pulsado sobre el anillo mitral en sus porciones parietal y septal. Los resultados obtenidos fueron:-para la porción parietal del anillo mitral: término a (ap): 0,2714 seg. ± 0,0406 seg.; término b (bp): 0,1591 seg. ± 0,0190 seg.; Índice de Tei: 0,72seg. ± 0,2785seg; -para la porción septal del anillo mitral: término a(as): 0,2721 seg. ± 0,0343 seg.; término b(bs): 0,1613 seg. ± 0,0196 seg; Índice de Tei: 0,70seg. ± 0,2223 seg.No se observaron diferencias estadísticamente significativas entre los términos ap - as (P= 0,904);  bp - bs (P= 0,495) y entre los valores del índice de Tei de ambas posiciones (P= 0,63).  La  correlación entre los valores del IPM y la frecuencia cardiaca fueron: r = -0,189 (para ITei por Doppler tisular septal); r = -0,165 (para ITei por Doppler tisular parietal).","palabras_clave":"ITei|Doppler |sistodiastolica|perro"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":40,"idioma_id":4,"titulo":"Assessing the glyphosate tolerance of Lotus corniculatus and L. tenuis to perform rhizoremediation strategies in the Humid Pampa (Argentina)","resumen":"The broad-spectrum herbicide glyphosate (N ? phosphonomethylglicine) is the most common pesticideused in the Humid Pampa, the main agricultural region in Argentina. According to agronomical practicesand topogeographical characteristics of the region, rhizoremediation arises as a promising technologyto mitigate glyphosate impact on health and agroecosystems. Lotus corniculatus L. (birdsfoot trefoil) andLotus tenuis Waldst. et Kit. (=Lotus glaber Mill., narrowleaf trefoil) were selected to carry out tolerancestudies as the starting point of a rhizoremediation process. L. corniculatus presented the highest rootand foliar tolerance to glyphosate, corresponding to 5.0 mg kg&#8722;1and 700 g ha&#8722;1respectively. The enzymeenolpyruvylshikimate-3-phosphate synthase (EPSP synthase) partial cDNA sequence and whole plantshikimate accumulation assay were performed on L. corniculatus in order investigate tolerance mech-anisms. No amino acid substitution related to glyphosate tolerance was found on EPSP synthase cDNAsequence. The shikimate accumulation study indicates that limited uptake and\/or translocation of theherbicide is the most probable tolerance mechanism. Results obtained in this study, plus the produc-tive and adaptive advantages of L. corniculatus make it a valuable candidate to develop rhizoremediationstrategies.","palabras_clave":"Rhizoremediation|Glyphosate|Agroecosystems|Humid Pampa region"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":41,"idioma_id":4,"titulo":"Affordable Solar Powered Housing for Poor Enclaves as a Possibility Option to Address Rural Housing Deficit","resumen":"This article presents an affordable house model for rural area, which uses energy conservation and passive solar systems for daytime heating of and dry solar toilet, which reduces the need for water use. This house has a low cost adapted to possibilities of peoples with scarce economic resources and is a candidate to alleviate the rural housing deficit. At the same time, would enable improve expectations in the rural area and reduce migration to urban areas with the consequent increase in poverty in cities.","palabras_clave":"AFFORDABLE SOLAR HOUSING|PASSIVE SOLAR SYSTEMS|DRY SOLAR TOILET"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":43,"idioma_id":4,"titulo":"Effect on temporary protection and adhesion promoter of silane nanofilms applied on electro-galvanized steel","resumen":"In this paper, the effectiveness of &#947;-mercaptopropyltrimethoxysilane (MTMO) films as temporary corrosion protection and adhesion promoter on electro-galvanized steel was studied. The films were synthesized from hydrolyzed MTMO with ethanol or methanol, applied by immersion on electro-galvanizedsteel and cured under different conditions. The porosity of the coating was evaluated by cyclic voltammetry, the corrosion behavior by polarization curves and the protection degree by exposure in the humidity and prohesion chambers. The films were characterized by scanning electron microscopy (SEM)and energy dispersive spectroscopy (EDS). From the obtained experimental results, it was concluded that this protection is markedly affected by the coating curing conditions and the alcohol used in the hydrolysis. MTMO is a good temporary protector against electro-galvanized steel corrosion in high humidity environment but it is less effective in environments containing aggressive ions such as Cl-1 and SO4 -2.In a second stage, pretreated samples were coated with an alkyd anticorrosive paint and exposed to the salt spray chamber. Dry adhesion tests as well as SEM and EDS studies were also done in order to know the nature of the disbonding fails (adhesion or cohesion).","palabras_clave":"ELECTROGALVANIZED STEEL|TEMPORARY PROTECTION|ADHESION|SOL-GEL PRETREATMENTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":44,"idioma_id":4,"titulo":"Widespread dispersion of the resistance element tet(B)::ISCR2 in XDR  Acinetobacter        baumannii isolates.","resumen":"Acinetobacter baumannii is a significant nosocomial pathogen often associated with extreme drug resistance (XDR). In Argentina, isolates of A. baumannii resistant to tetracyclines have accounted for more than 40% of drug-resistant isolates in some hospitals. We have previously reported the dispersion of the tet(B) resistance element associated with the ISCR2 transposase in epidemiologically unrelated A. baumannii isolates recovered from 1983 to 2011. This study extends this surveillance to 77 recent (2009-2013) XDR A. baumannii isolates with different levels of minocycline susceptibility. Isolates were examined by a pan-PCR assay, which showed six different amplification patterns, and specific PCRs were used for the confirmation of the the &#916;ISCR2-tet(B)-tet(R)-ISCR2 element. The tet(B) gene was present in 66 isolates and the ISCR2 element in 68 isolates; the tet(B) gene was associated with ISCR2 in all tet(B)-positive isolates. We conclude that this element is widespread in XDR A. baumannii isolates from Argentina and could be responsible for the emergence of tetracycline resistance in recent years.","palabras_clave":"Acinetobacter baumannii|transposons|plasmids|tetracicline"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":45,"idioma_id":5,"titulo":"La política social y sus efectos sobre la pobreza durante distintas etapas macroeconómicas. Argentina, 1992-2012","resumen":"El artículo analiza los cambios registrados en la política social en la Argentina durante las fases de implementación de reformas estructurales y el ciclo de crecimiento bajo políticas heterodoxas. El trabajo tiene como objetivo evaluar el modo en que el gasto público social ?los programas de asistencia social directa, los planes de protección al desempleo y los ingresos por jubilaciones y pensiones- incidieron sobre las tasas de pobreza e indigencia. En primer lugar, se examinan los cambios en el volumen y la composición del gasto público social. En segundo lugar, se presenta un modelo de descomposición que permite identificar los efectos del crecimiento económico, la distribución del ingreso y las políticas sociales sobre los cambios en las tasas de pobreza e indigencia. Se utilizan datos de organismos públicos y micro datos de la Encuesta Permanente de Hogares del Instituto Nacional de Estadística y Censos.","palabras_clave":"Políticas sociales|Pobreza|Indigencia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":46,"idioma_id":4,"titulo":"Kinetic study of the selective hydrogenation of styrene over a Pd egg-shell composite  catalyst","resumen":"This is a study on the kinetics of the liquid-phase hydrogenation of styrene toethylbenzene over a catalyst of palladium supported on an inorganic-organiccomposite. This support has a better mechanical resistance than other commercialsupports, e.g. alumina, and yields catalysts with egg-shell structure and a very thin active Pd layer. Catalytic tests were carried out in a batch reactor by varying temperature, total pressure and styrene initial concentration between 353-393 K, 10-30 bar, and 0.26-0.60 mol L-1. Kinetic models were developed on the assumptions of dissociative hydrogen chemisorption and non-negligible adsorption of hydrogen and styrene. Final chemical reaction expressions useful for reactor design were obtained. The models that best fitted the experimental data were those ones that considered the surface reaction as the limiting step. In this sense, a two-step Horiuti-Polanyi working mechanism with half hydrogenation intermediates gave the best fit of the experimental data. The heats of adsorption of styrene and ethylbenzene were also estimated.","palabras_clave":"styrene|selective hydrogenation|palladium|composite support"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":47,"idioma_id":4,"titulo":"99mTc-Ciprofloxacin Imaging: Still an Unsettled Issue?","resumen":"The objective of this work consisted in the assessment of 99mTc-ciprofloxacin imaging performance as a diagnostic tool in an experimental rat model of osteomyelitis. Bone (tibia) infection was induced in adult rats by inoculation of a suspension containing S. aureus suspended in fibrin glue. In vivo studies by means of small animal imaging were conducted using a gamma camera. The study shows the correlation between 99mTc-ciprofloxacin positive images with bacterial bone count but also with histopathological findings in an osteomyelitis animal model, highlighting its potential as a tool in preclinical research and the accomplishment of 3Rs concept regarding welfare of laboratory animals. 99mTc-MDP scintigraphy, failed to show these correlations and therefore it may be proposed as a complementary method to diagnose and follow up the bone physiopathology in this animal model. Future perspectives of small animal imaging in order to potentiate osteomyelitis basic research will derive from numerous research works, and 99mTc-ciprofloxacin may still be a candidate for infectious diagnose and follow-up as demonstrated in this study.","palabras_clave":"INFECTION|INFLAMMATION|OSTEOMYELITIS|STAPHYLOCOCCUS AUREUS|SMALL ANIMAL IMAGING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":48,"idioma_id":4,"titulo":"Influence of plant growth regulators on Expansin2 expression in strawberry fruit. Cloning and functional analysis of FaEXP2 promoter region","resumen":"AbstractFaEXP2 encodes a fruit-specific expansin that is known to be associated with cell wall loosening and fruit softening in strawberry (Fragaria  ananassa Duch.). In spite of its relevant role in fruit ripening, little is known about the hormonal regulation of this gene. In the present study, we isolated a 650 bp fragment of the FaEXP2 gene promoter and the in silico analysis revealed the presence of cis-acting elements associated with hormones, light and stress-related responses. With the aim of characterizing the hormonal regulation of FaEXP2 expression, strawberry fruit were treated with plant growth regulatorsand changes in transcript levels were analyzed by qPCR. FaEXP2 expression levels were significantly higher than control in fruit treated with abscisic acid (ABA), and when the endogenous source of auxins (achenes) was removed. In contrast, transcript accumulation was not affected by exogenous applications of gibberellic acid (GA3), naphtalenacetic acid (NAA), ethylene or 1-methylcyclopropene (1-MCP). Also, functional analysis of FaEXP2 gene promoter was performed by transient and permanent strawberry transformation. Histochemical GUS staining analysis showed that the 650 bp-promoter fragment was able to drive the reporter gene expression specifically to the receptacle and along ripening. Our results provide new insights into the hormonal regulation of FaEXP2 expression.","palabras_clave":"Expansin|Plant growth regulator|Promoter|Ripening|Strawberry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":49,"idioma_id":4,"titulo":"Involvement of the crustacean hyperglycemic hormone (CHH) in the physiological compensation of the freshwater crayfish Cherax quadricarinatus to low temperature and high salinity stress","resumen":"This study was aimed at determining the role ofthe crustacean hyperglycemic hormone (CHH) in the physiologicalcompensation to both saline and thermal stress, inthe freshwater crayfish Cherax quadricarinatus. By determiningthe expression of the CHH gene in the eyestalk ofjuvenile crayfish, we found that maximal induction of CHHwas induced at high salinity (10 g\/L) and low temperature(20 °C). In order to investigate the role of CHH in thephysiological compensation to such stressful conditions,recombinant CHH was supplied to stressed animals. CHHinjectedcrayfish showed increased hemolymphatic levelsof glucose, in accordance with a significant utilization ofglycogen reserves from the hepatopancreas. Furthermore,CHH administration allowed stressed animals to regulatehemolymphatic sodium and potassium at more constantlevels than controls. Taken together, these results suggesta relevant role of CHH in increasing the energy availableintended for processes involved in the physiological compensationof C. quadricarinatus to both saline and thermalstress.","palabras_clave":"CHH|Cherax quadricarinatus|Stress|Salinity|Temperature"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":51,"idioma_id":4,"titulo":"An Overview Of Proteomics Tools For Understanding Plant Defense Against Pathogens","resumen":"Plant diseases are responsible for important losses in crops and cause serious impacts in agricultural production. In the last years, proteomics has been used to examine plant defense responses against pathogens. Such studies may be pioneer in the generation of crops with enhanced resistance. In this review, we focus on proteomics advances in the understanding of host and non-host resistance against pathogens.","palabras_clave":"PROTEOMICS|PLANT DEFENSE RESPONSES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":52,"idioma_id":4,"titulo":"Pesticide chlorpyrifos acts as an endocrine disruptor in adult rats causing changes in mammary gland and hormonal balance","resumen":"Previamente mostramos que el plaguicida clorpirifos (CPF) actúa como disruptor endócrino (DE) en glándula mamaria de rata. Objetivo: estudiar los efectos del CPF sobre el eje hipófisis-ovario y sus acciones sobre el útero, principal órgano blanco de este eje. Métodos: Ratas Sprague-Dawley hembras de 40 días de vida fueron expuestas a CPF 0,01 (CPF 0,01) y 1 mg\/Kg\/día (CPF 1) o vehículo (C) durante 100 días por vía oral. Determinamos: niveles de estradiol (E2), progesterona (Pg) y testosterona (T) en suero y ovario, y niveles séricos de gonadotrofinas (LH y FSH) por radioinmunoensayo; expresión de las enzimas esteroidogénicas CYP11 y CYP19 por PCR en tiempo real; expresión del receptor de estrógeno alfa (RE&#945;), del receptor de progesterona (RPg) y del marcador de proliferación PCNA por inmunohistoquímica en los úteros. Resultados: CPF 1 reduce el E2 (11,7 ± 3,0 vs. 22,3 ± 6,3 pg\/ml del C, p&lt;0,05) y la Pg séricos (2,1 ± 0,7 vs. 4,0 ± 0,8 ng\/ml del C, p&lt;0,05), sin alterar la concentración de T. El contenido ovárico de E2 fue reducido por CPF 1 (363,3 ± 224,4 vs. 1385,4 ± 507,3 ng del C, p&lt;0,05) junto con una menor expresión de CYP 11 (41%, p&lt;0,001), sin cambios en CYP19. Por otra parte, el CPF 0,01 y 1 redujeron los niveles de LH (1,4 ± 0,1 y 1,9 ± 0,3 respectivamente, vs. 2,8 ± 0,2 ng\/ml del C, p&lt;0,01), sin alterar la concentración de FSH. A su vez, CPF 1 disminuyó la liberación de LH (6,1 ± 1,7 vs. 15,8 ± 2,7 ng\/ml del C, p&lt;0,05) en ratas ovariectomizadas. En útero, CPF 1 incrementó la expresión del RPg en las glándulas endometriales (81%, p&lt;0,05), mientras que CPF 0,01 aumentó la expresión del RPg (85,7%, p&lt;0,05) y del RE&#945; (62,2%, p&lt;0,05) en endometrio. La expresión de PCNA y el peso del útero no fueron alterados por CPF. Conclusión: estos resultados demuestran que el CPF actúa como un DE, afectando la síntesis de hormonas esteroideas, su regulación hipofisaria y la expresión de sus receptores en útero, alertando sobre sus efectos en la salud reproductiva","palabras_clave":"CHLORPYRIFOS|ENDOCRIN DISRUPTOR|MAMMARY GLAND|BRAST CANCER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":56,"idioma_id":4,"titulo":"Active potassium niobates and titanoniobates as catalysts for organic sulfide remediation","resumen":"Pure (KNbO3) and titanium-substituted (KTi0.1Nb0.9O3 and KTi0.2Nb0.8O3) potassium niobates with perovskite crystalline structures were prepared, characterized and tested as catalysts in the selective oxidation of 2-(methylthio)benzothiazole to its corresponding sulfoxide and sulfone. These catalysts, which have not previously been reported for organic sulfide remediation, are the most active catalysts among those discovered to date for this type of oxidation reaction. Hydrogen peroxide was employed as the oxidant, and the reaction parameters were tested in order to find milder reaction conditions.","palabras_clave":"Niobates|Zeolites|Titanium|sulfide remediation|hydrogen peroxide"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":58,"idioma_id":4,"titulo":"Extraction of sunflower oil using ethanol as solvent","resumen":"The ethanolic extraction of oil from sunflower collets was studied and compared with previous data where hexane was used as extraction solvent. First, the extractive power of ethanol was determined by Soxhlet. It gave a higher yield of extracted material, whose content of soluble hexane components (oil phase) was similar to that obtained with n-hexane. When ethanol was used as solvent, 70% less crystallizable waxes and at least 38% more tocopherols and phospholipids were extracted. In addition, ethanol showed great ability to extract sugar, mainly raffinose and sucrose, extracting over 75% of the initial sugar content.Then, the kinetics of ethanolic extraction was studied at 50 and 60 °C in a batch reactor. At equilibrium conditions, it was observed that extraction could be limited by the solubility of the extractable material. Oil effective diffusivities were 9.94 10-10 at 50 ºC and 3.11 10-9 m2\/s at 60 ºC. From the point of view of the quality of the obtained products, this work demonstrated the feasibility of using ethanol as an alternative solvent to hexane in the oil extraction from sunflower collets.","palabras_clave":"ETHANOL|SUNFLOWER OIL|SOLVENT EXTRACTION|MINOR COMPOUNDS|SUGARS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":60,"idioma_id":4,"titulo":"The role of magma mixing and mafic recharge in the evolution of a back-arc quaternary caldera: The case of Pay´un Matr´u,Western Argentina","resumen":"p { margin-bottom: 0.25cm; line-height: 120%; }The Quaternary Payún Matrú volcano is along-lived edifice that developed a summit caldera 8 km wide, withabundant pre- and post-caldera volcanic activity. It is the mainvolcano of the Payún Matrú Volcanic Field, which is located in theback-arc Payenia Basaltic Province, at mid-western Argentina. Thecomposition of Payún Matrú is mainly trachytic, with lesser amountsof trachyandesitic and basaltic trachyandesitic lavas. The PayúnMatrú Volcanic Field includes also the Payún Liso stratovolcano andmore than 200 monogenetic basaltic cones and associated lava flowsthat are located east and west of the caldera. The aim of this workis to show the Payún Matrú evolution based on the mineralogical andtextural characterization and to make inferences on the triggermechanism for the explosive eruption which lead to the calderaformation. Some intermediate lavas and trachytes include phenocrystswith contrasting textures and composition, such as inverse zoning inplagioclase and clinopyroxenes, sieved plagioclases with a morecalcic rim and calcic plagioclases with a more sodic rim, indicatingthat they could not have formed together and suggesting magma mixingprocesses. In addition, a few lavas show mafic enclaves or texturallydifferent groundmasses with fluidal contacts, indicating minglingbetween two magmas. These lavas are found in the pre-caldera stageand the early post-caldera stage of Payún Matrú.The trachytic pyroclastic deposits related to the caldera collapsedo not exhibit evidenceof hybridization, althoughtheypresent a minorproportion of dissolvedfeldspars and biotite replaced by anhydrous minerals, suggestingthat a restricted zone of the chamber wasreheated. This may beexplained by a mafic recharge event wherepart of the host trachytic magma was heated, butwithout acomplete homogenizationbetween the hostand recharging magmas. These features, in addition to theabundant basaltic volcanism east and west of the caldera, suggestthat the trigger mechanism for the explosive eruption was theinjection of basaltic magma into the trachytic chamber of PayúnMatrú.","palabras_clave":"PAYÚN MATRÚ CALDERA|TRACHYTES|MAGMA MIXING|ERUPTION TRIGGER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":65,"idioma_id":4,"titulo":"Demography and population growth rate of the tree Prosopis flexuosa with contrasting grazing regimes in the Central Monte Desert","resumen":"ab stra ctOne of the most important current challenges for ecologists is to evaluate how human-induced changes in ecosystems would impact viability of populations. Demographic response to anthropogenic impact could help us to understand how to manage those impacts. Using demographic techniques and popula- tion projection models, here we assess if demography and population dynamics of the tree Prosopis flexuosa change in cattle grazed areas compared to ungrazed areas in the Central Monte desert, Mendoza, Argentina. To this end, we quantified vital rates and constructed a population projection matrix model to compare the deterministic population growth rate (k) between grazed and ungrazed areas. We also estimated elasticities of vital rates to evaluate their potential importance for future changes in k and performed a life table response experiment (LTRE) to identify the life cycle transitions that contribute the most to the observed differences in k between the two treatments. Although we found differences in demographic processes, such as lower seed production and higher probability of reversion to smaller size classes in young individuals when cattle were present, our results indicate that cattle grazing had no significant effect on k for this species. According to the elasticity analysis, survival of large trees is the main driver of the population growth rate (k)of P. flexuosa, and the vital rates related to tree reproduc- tion, such as seed production and germination, have a poor contribution to k. Therefore, limitations of activities that can affect survival of large trees should be considered as part of the conservation strategy for this species. Our study provides a compilation of demographic information that can be useful to set policies connecting the conservation objectives for this woodlands with that of ranch managers of the area.?","palabras_clave":"ALAGARROBO|CATTLE GRAZING|LIFE TABLE RESPONSE EXPERIMENTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":66,"idioma_id":4,"titulo":"Looking for the interactions between omeprazole and amoxicillin in a disordered phase. An experimental and theoretical study","resumen":"In this paper, co-grinding mixtures of omeprazole?amoxicillin trihydrate (CGM samples) and omeprazole?anhydrous amoxicillin (CGMa samples) at 3:7, 1:1 and 7:3 molar ratios, respectively, were studied with theaim of obtaining a co-amorphous system and determining the potential intermolecular interactions. Thesesystems were fully characterized by differential scanning calorimetry (DSC), FT-infrared spectroscopy (FTIR),X-ray powder diffraction (PXRD), scanning electron microscopy (SEM) and solid state Nuclear Magnetic Resonance(ssNMR). The co-grinding process was not useful to get a co-amorphous system but it led to obtainingthe 1:1 CGMa disordered phase. Moreover, in this system both FTIR and ssNMR analysis strongly suggest intermolecularinteractions between the sulfoxide group of omeprazole and the primary amine of amoxicillin anhydrous.The solubility measurements were performed in simulated gastric fluid (SGF) to prove the effect of theco-grinding process. Complementarily, we carried out density functional theory calculations (DFT) followed byquantum theory of atoms in molecules (QTAIM) and natural bond orbital (NBO) analyses in order to shedsome light on the principles that guide the possible formation of heterodimers at the molecular level, whichare supported by spectroscopic experimental findings","palabras_clave":"OMEPRAZOLE|AMOXICILLIN|DRUGS INTERACTIONS|DISORDERED PHASES|DFT|QTAIM|NBO|FTIR|ssNMR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":67,"idioma_id":4,"titulo":"Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei.","resumen":"AbstractBackground: Poly(ADP-ribose) (PAR) metabolism participates in several biological processes such as DNA damage signaling and repair, which is a thoroughly studied function. PAR is synthesized by Poly(ADP-ribose) polymerase (PARP) and hydrolyzed by Poly(ADP-ribose) glycohydrolase (PARG). In contrast to human and other higher eukaryotes, Trypanosoma brucei contains only one PARP and PARG. Up to date, the function of these enzymes has remained elusive in this parasite. The aim of this work is to unravel the role that PAR plays in genotoxic stressresponse.Methods: The optimal conditions for the activity of purified recombinant TbPARP were determined by using a fluorometric activity assay followed by screening of PARP inhibitors. Sensitivity to a genotoxic agent, H2O2, was assessed by counting motile parasites over the total number in a Neubauer chamber, in presence of a potent PARP inhibitor as well as in procyclic transgenic lines which either down-regulate PARP or PARG, or over-express PARP.Triplicates were carried out for each condition tested and data significance was assessed with two-way Anova followed by Bonferroni test. Finally, PAR influence was studied in cell death pathways by flow cytometry.Results: Abolition of a functional PARP either by using potent inhibitors present or in PARP-silenced parasites had no effect on parasite growth in culture; however, PARP-inhibited and PARP down-regulated parasites presented anincreased resistance against H2O2 treatment when compared to their wild type counterparts. PARP over-expressing and PARG-silenced parasites displayed polymer accumulation in the nucleus and, as expected, showed diminished resistance when exposed to the same genotoxic stimulus. Indeed, they suffered a necrotic death pathway, while an apoptosis-like mechanism was observed in control cultures. Surprisingly, PARP migrated to the nucleus and synthesized PAR only after a genomic stress in wild type parasites while PARG occurred always in this organelle.Conclusions: PARP over-expressing and PARG-silenced cells presented PAR accumulation in the nucleus, even in absence of oxidative stress. Procyclic death pathway after genotoxic damage depends on basal nuclear PAR. Thisevidence demonstrates that the polymer may have a toxic action by itself since the consequences of an exacerbated PARP activity cannot fully explain the increment in sensitivity observed here. Moreover, the unusual localization ofPARP and PARG would reveal a novel regulatory mechanism, making them invaluable model systems.","palabras_clave":"TRYPANOSOMA BRUCEI|ADP-RIBOSE|CELL DEATH|GENOTOXIC DAMAGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":68,"idioma_id":4,"titulo":"Postharvest behaviour of watercress minimally processed","resumen":"Watercress is an aquatic plant of the Brassicaceae family. It is a leafy vegetable that grows in and around water, it is consumed raw or steamed and it has a short shelf life of approximately seven days. The objective of this study was to evaluate the postharvest behaviour of watercress (Nasturtium officinaleR. Br.) minimally processed and stored at optimal storage temperature vs. market temperature. Treatments were: shoots packed with plain film (PD961EZ, 31µm thickness) and stored in refrigerated chambers at 1 ± 0.5 ºC and 8 ± 2 ºC for 10 days. Overall visual quality, gas concentration inside the packages, chlorophyll, reducing sugar, ascorbic acid, oxalic acid and weight loss were evaluated. At the end of the storage period overall visual quality, gas concentration and reducing sugars were affected by storage time and temperature, meanwhile dehidro ascorbic, oxalic acid and weight loss were not. ","palabras_clave":"Nasturtium officinale,      |quality,|gas concentration,|chlorophyll,|weight loss, |ascorbic acid,|reducing sugar,|oxalic acid"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":69,"idioma_id":4,"titulo":"Effect of beet flour on films made from biological macromolecules: native and modified plantain flour","resumen":"Biological macromolecules such as starches of different amylaceous sources have been used in the formulation of edible films. However, there are few studies aimed at evaluating edible and intelligent films with response to pH changes from natural pigments, this despite the importance of these materials. In this context, films from native and modified plantain flour, plasticized with glycerol, with or without the addition of beet flour were developed. The chemical and structural composition of the flours, and its incidence on thickness, water solubility, contact angle, and mechanical and microstructural properties were evaluated, thus as its response to pH changes of the developed films. The observations showed that the incorporation of beet flour allowed to obtain intelligent films front to pH changes alkaline. Likewise, the betalains that were found in beet flour interacted more efficiently with the phosphated plantain flour, limiting well its immediate response to pH changes. In the same way, proteins and sugars of beet flour allowed to obtain more flexible films, due to the hydrogen bond interactions between these constituents and the plantain flours. This latter could justify the decrease of contact angle, and the increase on thickness and solubility of these films.","palabras_clave":"Plantain and beet flours|Modified flour|Intelligent films"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":71,"idioma_id":4,"titulo":"Biodegradable and non-retrogradable eco-films based on starch-glycerol with citric acid as crosslinking agent","resumen":"Biodegradable and non-retrogradable starch-glycerol based films were obtained using citric acid (CA) as crosslinking agent at 75 °C. This material allowed decreasing water vapor permeability (WVP) more than 35 %, remained amorphous for at least 45 days as a result of the network formed by the CA that avoided starch retrogradation and maintained the degradability in compost, occurring only six days after the films without citric acid. A simulation of the gelatinization process of starch-glycerol with and without CA, using a differential thermal analysis device, showed that the system with CA completed the gelatinization 5 ºC before than the other and, CA first reacted with glycerol and then starch-glycerol-CA reaction occurred. The temperature at which the gelatinization process was carried out was critical to obtain the best results. An increase of gelatinization process temperature at 85 °C in system with CA, led to a worsening on WVP and its integrity after a swelling process with dimethylsulphoxide (DMSO), compared to the films processed at 75 ºC.","palabras_clave":"STARCH|CITRIC ACID|CROSSLINKING|BIODEGRADABLE EDIBLE FILMS|BIODEGRADABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":72,"idioma_id":4,"titulo":"Atomic force microscopy (AFM) and 3D confocal microscopy as alternative techniques for the morphological characterization of anodic TiO2 nanoporous layers","resumen":"The morphologiccharacterizationofself-organizedTiO2 nanostructures by field emissionscanningelectron microscopy(FESEM)andtransmissionelectronmicroscopy(TEM)wascomparedwithresultsobtained bybothatomicforcemicroscopy(AFM)and3Dconfocalmicroscopy,whichwereemployedasalternativecharacterizationmethods.ItisdemonstratedthatAFMwithtuningforkconfiguration (in-termittentmode)isalsoapowerfultoolthatallowsobtainingconclusiveinformationonthemorphologyof one-dimensionalnanostructures.3Dconfocalmicroscopyemployedforthe first timeforobtainingthickness ofnanoporousTiO2 films, isanewandpowerfulmethodthatprovidesdefinite informationonthickness ofthenanostructures.Theresultsemployedforthecharacterizationarefairlyreliablebesidesnovelandinteresting.","palabras_clave":"3D CONFOCAL MICROSCOPY|MATERIALS CHARACTERIZATION|THIN FILMS|TIO2 NANOPOROUS|TUNING FORK AFM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":73,"idioma_id":4,"titulo":"An Insight into the Role of Glycerol in Chitosan Films","resumen":"This work was focused on assessing the influenceof the glycerol in chitosan matrices, analyzing the changesproduced in the molecular mobility, mechanical, thermal, barrierand structural properties. The addition of glycerol in thematrix decreased the stress values, increasing the elasticityand water vapor permeability of the films, with a markeddecrease in glass transition temperature. Detailed analyses ofFourier Transform IR Spectroscopy spectra supported the observedchanges, especially in the spectral windows 1700?1500 cm&#8722;1 revealing the modifications at molecular levelcaused by hydrogen bond interactions between chitosan andwater in the presence of glycerol. Positron annihilation spectroscopic(PALS) measurements allowed determining the freevolume assuming spherical holes as well as monitoring thestructural changes in chitosan films caused by the additionof both, glycerol and water molecules. It was possible to inferthat for unplasticized matrices, a sustained increase of theradius between 0.06 and 0.2 of Xwater was observed, followedby a plateau up to 0.35. In the other case, with the addition ofglycerol, there were two plateaus, the first between 0.25 and0.37 of Xwater, and the second from 0.41 to 0.47. For higherglycerol concentrations, the plasticizer would be mainlybounded to the chitosan pack more efficiently and the waterpresent in the system would be predominantly free in the matrix causing its swelling. Findings on molecular mobilitycontributed to the understanding of the role of water and glycerolin the structural arrangement and its influence on filmproperties.","palabras_clave":"chitosan|PALS|FTIR|Moleculas mobility"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":76,"idioma_id":4,"titulo":"Transbilayer asymmetry and sphingomyelin composition modulate the preferential membrane partitioning of the nicotinic acetylcholine receptor in Lo domains","resumen":"We have previously shown that the intact nicotinic acetylcholine receptor (AChR) lacks preference for Lo domains when reconstituted in a sphingomyelin (SM), cholesterol (Chol) and POPC (1:1:1) model system (Bermúdez V, Antollini SS, Fernandez-Nievas GA, Avelda no MI, Barrantes FJ. J. Lipid Res. 2010; 51: 2629~ e2641). Here, we have furthered our studies by characterizing the influence of different lipid host compositions on the distribution of purified AChR reconstituted in two model systems (POPC:Chol, 1:1 and POPC:Chol:SM, 1:1:1), involving a) different SM species (porcine brain SM (bSM), 16:0-SM, 18:0-SM or 24:1-SM); or b) induced transbilayer asymmetry, resulting from enrichment in bSM in the external hemilayer. AChR distribution was evaluated by fluorescence resonance energy transfer efficiency between the AChR intrinsic fluorescence and Laurdan or dehydroergosterol fluorescence, and by analyzing the distribution of AChR in detergent-resistant and detergent-soluble fractions (1% Triton X-100, 4 C).bSM-induced transbilayer asymmetry or the presence of 16:0-SM and\/or 18:0-SM (unlike bSM or 24:1-SM) resulted in the preferential partitioning of AChR in Lo domains, suggesting that the localization of AChR in ordered domains strongly depends on the characteristics of the host lipid membrane, and in particular on the sphingolipid composition and transbilayer asymmetry.","palabras_clave":"nicotinic acetylcholine receptor|lipid-protein interaction|asymmetry|sphingolipids"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":78,"idioma_id":4,"titulo":"Spatio-temporal structures of rainfall over the Amazon basin derived from TRMM data","resumen":"On the basis of Tropical Rainfall Measuring Mission (TRMM) daily accumulated rainfall data (3B42 v7product) covering 16 years (1998?2013), the Amazon Basin (AB) time and space rainfall variability is analysed. Different behaviours of precipitation over AB are found to the north and south of 8&#8728;S when the longitudinal band 70&#8728;?50&#8728;W is considered. The sample is then split into northern and southern sectors with respect to 8&#8728;S, describing their monthly evolution as a function of longitude. The main spatial oscillation modes are isolated and analysed through continuous wavelet transform analysis. Intense spatial oscillations are found close to the western side of the studied region. Several temporal modes in different scales are detected within each sample. Two of them showscales longer than 12months,which are probably associated with ENSO phases. Smaller scale oscillations, evaluated from daily data, are also found. The northern sector of AB shows more daily data variability than the southern one and seems to be more affected by large temporal processes than the southern sector.","palabras_clave":"RAINFALL|AMAZON"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":79,"idioma_id":4,"titulo":"Immunization with Neospora caninum profilin induces limited protection and a regulatory T-cell response in mice","resumen":"Profilins are actin-binding proteins that regulate the polymerization of actin filaments. In apicomplexan parasites, they are essential for invasion. Profilins also trigger the immune response of the host by activating TLRs on dendritic cells (DCs), inducing the production of pro-inflammatory cytokines. In this study we characterized for the first time the immune response and protection elicited by a vaccine based on Neospora caninum profilin in mice. Groups of eight BALB\/c mice received either two doses of a recombinant N. caninum profilin expressed in Escherichia coli. (rNcPRO) or PBS, both formulated with an aqueous soy-based adjuvant enriched in TLR-agonists. Specific anti-profilin antibodies were detected in rNcPRO-vaccinated animals, mainly IgM and IgG3, which were consumed after infection. Splenocytes from rNcPRO-immunized animals proliferated after an in vitro stimulation with rNcPRO before and after challenge. An impairment of the cellular response was observed in NcPRO vaccinated and infected mice following an in vitro stimulation with native antigens of N. caninum, related to an increase in the percentage of CD4+CD25+FoxP3+. Two out of five rNcPRO-vaccinated challenged mice were protected; they were negative for parasite DNA in the brain and showed no histopathological lesions, which were found in all PBS-vaccinated animals. As a whole, our results provide evidence of a regulatory response","palabras_clave":"Profilin|Neospora caninum|dendritic cells|vaccine|regulatory response"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":80,"idioma_id":4,"titulo":"Isolation and clinical sample typing of human leptospirosis cases in Argentina","resumen":"Leptospira typing is carried out using isolated strains. Because of difficulties in obtaining them, direct identification of infective Leptospira in clinical samples is a high priority. Multilocus sequence typing (MLST) proved highly discriminatory for seven pathogenic species of Leptospira, allowing isolate characterization and robust assignment to species, in addition to phylogenetic evidence for the relatedness between species. In this study we characterized Leptospira strains circulating in Argentina, using typing methods applied to human clinical samples and isolates. Phylogenetic studies based on 16S ribosomal RNA gene sequences enabled typing of 8 isolates (6 Leptospira interrogans, one Leptospira wolffii and one Leptospira broomii) and 58 out of 85 (68.2%) clinical samples (55 L. interrogans, 2 Leptospira meyeri, and one Leptospira kirschneri). MLST results for the L. interrogans isolates indicated that five were probably Canicola serogroup (ST37) and one was probably Icterohaemorrhagiae serogroup (ST17). Eleven clinical samples (21.6%), provided MLST interpretable data: five were probably Pyrogenes serogroup (ST13), four Sejroe (ST20), one Autumnalis (ST22) and one Canicola (ST37). To the best of our knowledge this study is the first report of the use of an MLST typing scheme with seven loci to identify Leptospira directly from clinical samples in Argentina. The use of clinical samples presents the advantage of the possibility of knowing the infecting strain without resorting to isolates. This study also allowed, for the first time, the characterization of isolates of intermediate pathogenicity species (L. wolffii and L. broomii) from symptomatic patients.","palabras_clave":"Leptospira spp|MLST|16S rRNA|serotyping"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":82,"idioma_id":4,"titulo":"Biological control of AFB1-producing Aspergillus section Flavi strains isolated from brewer's grains, alternative feed intended for swine production in Argentina","resumen":"The aim of the present study was to investigate the inhibitory activity of lactic acid bacteria (LAB) isolated from brewer?s grains on Aspergillus section Flavi growth and aflatoxin B1 production. The Aspergillus strains tested were inhibited by all the LAB strains assayed. The isolates Lactobacillus brevis B20, P. pentosaceus B86, Lactococcus lactis subsp. lactis B87, L. brevis B131, and Lactobacillus sp. B144 completely suppressed the fungal growth and reduced aflatoxin B1 production. In conclusion, LAB isolated from brewer?s grains show a high inhibitory activity on fungal growth and aflatoxin biosynthesis by Aspergillus flavus and Aspergillus parasiticus. Further studies must be conducted to evaluate the success of in vitro assays under food environment conditions and to elucidate the antifungal mechanism of these strains.","palabras_clave":"Aflatoxins|antifungal activity|Aspergillus flavus|Aspergillus parasiticus|lactic acid bacteria"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":84,"idioma_id":5,"titulo":"ISÓTOPOS ESTABLES Y DIETA DE LOS CAZADORES RECOLECTORES DEL SUDOESTE BONAERENSE (ARGENTINA)","resumen":"Se presentan los primeros resultados del análisis de isótopos estables (&#948;13C y &#948;15N) obtenidos sobre restos humanos provenientes de sitios arqueológicos del sudoeste de la provincia de Buenos Aires (Argentina), datados en el Holoceno Tardío. Conjuntamente se informan los primeros datos de &#948;13 Ccol. sobre los distintos recursos faunísticos del sector.El área de estudio se compone de diversos ambientes, destacándose los entornos acuáticos como la costa marina, los valles fluviales, las lagunas y el humedal. Los valores isotópicos de los recursos del sector indican que los animales marinos presentan los valores más enriquecidos en 13C; mientras que aquellas especies terrestres (coipo, ñandú y herbívoros grandes) presentan los valores más empobrecidos, que son indistinguibles entre ellos. Por su parte, las aves acuáticas y el peludo tienen valores intermedios. El estudio isotópico sobre restos humanos reflejó que la dieta de los individuos fue cárnica, que las proteínas de animales terrestres fueron predominantes y que en menor proporción se usaron recursos marinos. El registro arqueofaunístico del área resulta concordante con esta información. Finalmente, estos son los primeros resultados isotópicos para el sector, por lo que constituye un aporte preliminar que deberá continuar con la realización de nuevos estudios","palabras_clave":"CAZADORES RECOLECTORES|ISOTOPOS ESTABLES|REGISTRO BIOARQUEOLOGICO Y ARQUEOFAUNISTICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":86,"idioma_id":4,"titulo":"Benchmarking Analogue Models of Brittle Thrust Wedges","resumen":"We performed a quantitative comparison of brittle thrust wedge experiments to evaluate the variability among analogue models and to appraise the reproducibility and limits of model interpretation. Fifteen analogue modeling laboratories participated in this benchmark initiative. Each laboratory received a shipment of the same type of quartz and corundum sand and all laboratories adhered to a stringent model building protocol and used the same type of foil to cover base and sidewalls of the sandbox. Sieve structure, sifting height, filling rate, and details on off-scraping of excess sand followed prescribed procedures.Our analogue benchmark shows that even for simple plane-strain experiments with prescribed stringent model construction techniques, quantitative model results show variability, most notably for surface slope, thrust spacing and number of forward and backthrusts. One of the sources of the variability in model results is related to slight variations in how sand is deposited in the sandbox. Small changes in sifting height, sifting rate, and scraping will result in slightly heterogeneous material bulk densities, which will affect the mechanical properties of the sand, and will result in lateral and vertical differences in peak and boundary friction angles, as well as cohesion values once the model is constructed. Initial variations in basal friction are inferred to play the most important role in causing model variability.Our comparison shows that the human factor plays a decisive role, and even when one modeler repeats the same experiment, quantitative model results still show variability. Our observations highlight the limits of up-scaling quantitative analogue model results to nature or for making comparisons with numerical models. The frictional behavior of sand is highly sensitive to small variations in material state or experimental set-up, and hence, it will remain difficult to scale quantitative results such as number of thrusts, thrust spacing, and pop-up width from model to nature.","palabras_clave":"Thrust wedges|Brittle wedges|Shear zones|Analogue modeling|Benchmarking|Critical Taper|Sand|Friction|Cohesion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":88,"idioma_id":4,"titulo":"Impact of multiple anthropogenic stressors on freshwater: how do glyphosate and the invasive mussel Limnoperna fortunei affect microbial communities and water quality?","resumen":"The study of the joint effect of multiple anthropogenic stressors is important because the emerging consequences are often unpredictable on the basis of knowledge of single effects. We explored the joint impact of glyphosate and the invasive golden mussel Limnoperna fortunei on freshwater phytoplankton, bacterioplankton andperiphyton, and on the physical and chemical properties of the water. We manipulatedboth stressors simultaneously in a 25-day experiment using outdoor mesocosms; weassayed technical-grade glyphosate acid at four concentrations: 0, 1, 3 and 6 mg glyL-1 under scenarios with and without mussels. The addition of the glyphosatesignificantly increased total phosphorus according to the concentration used; the high clearance rate of L. fortunei significantly decreased phytoplanktonic abundance leading to low values of turbidity. The mussel significantly stimulated the development of filamentous green algae (metaphyton). Interestingly, the combined effect revealed that L. fortunei accelerated the dissipation of glyphosate, which showed a 4-fold decrease in its half-life; this promoted the rapid bioavailability of glyphosate-derived phosphorus in the water. The interaction had a synergistic effect on soluble reactive phosphorus concentrations and was directly dependent on the concentration of glyphosate. A synergistic effect was also observed on bacterioplankton, water turbidity and metaphyton, thus inducing enhanced and rapid eutrophication. The ability of mussels to reduce glyphosate in water may be valued as positive, but our results allow us to predict that the invasion of Limnoperna fortunei in natural freshwater systems contaminated by glyphosate will accelerate the negative impact of the herbicide associated with eutrophication.","palabras_clave":"GLYPHOSATE|LIMNOPERNA FORTUNEI|ANTHROPOGENIC STRESSORS|OUTDOOR MESOCOSMS|EUTROPHICATION|SYNERGISM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":89,"idioma_id":4,"titulo":"Estradiol up-regulates c-FLIPlong expression in anterior pituitary cells","resumen":"Anterior pituitary cell turnover depends on a tight balance between proliferation and apoptosis. We have previously shown that estrogens sensitize anterior pituitary cells to pro-apoptotic stimuli. c-FLIP (cellular-FLICE-inhibitory-protein) isoforms are regulatory proteins of apoptosis triggered by death receptors. c-FLIPshort isoform competes with procaspase-8 inhibiting its activation. However, c-FLIPlong isoform may have a pro- or anti-apoptotic function depending on its expression level. In the present study, we explored whether estrogens modulate c-FLIP expression in anterior pituitary cells from ovariectomized (OVX) rats and in GH3 cells, a somatolactotrope cell line. Acute administration of 17&#946;-estradiol to OVX rats increased c-FLIPlong expression in the anterior pituitary gland without changing c-FLIPshort expression as assessed by Western blot. Estradiol in vitro also increased c-FLIPlong expression in anterior pituitary cells but not in GH3 cells. As determined by flow cytometry, the percentage of anterior pituitary cells expressing c-FLIP was higher than in GH3 cells. However, c-FLIP fluorescence intensity in GH3 cells was higher than in anterior pituitary cells. FasL increased the percentage of TUNEL-positive GH3 cells incubated either with or without estradiol suggesting that the pro-apoptotic action of Fas activation is estrogen-independent. Our results show that unlike what happens in nontumoral pituitary cells, estrogens do not modulate either c-FLIPlong expression or FasL-induced apoptosis in GH3 cells. The stimulatory effect of estradiol on c-FLIPlong expression could be involved in the sensitizing effect of this steroid to apoptosis in anterior pituitary cells. The absence of this estrogenic action in tumor pituitary cells could be involved in their tumor-like behavior.","palabras_clave":"ESTRADIOL|PITUITARY|C.FLIP|APOPTOSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":91,"idioma_id":4,"titulo":"Differential growth of Spartina densiflora populations under saline flooding is related to adventitious root formation and innate root ion regulation","resumen":"Global change anticipates scenarios of sea level rise that would provoke long lasting floods, especially in lowland areas of salt marshes. Our aim was to evaluate the morpho-physiological adjustment ability to deal with continuous saline flooding of Spartina densiflora Brogn. plants from lowlands and uplands along a subtle topographical gradient (0.2m differential altitude). Plants from both origins were subjected to continuous saline flooding (300mM NaCl) for 35 days. Responses associated to adventitious rooting, aerenchyma formation, concentration of Na+,K+ and Cl? in roots and shoots tissues, tillering and growth were assessed. Root responses differentiated populations given that lowland plants showed higher ability for adventitious root formation and innate superior root ion regulation than upland plants. High constitutive K+ concentration plus high Na+ exclusion in root tissues led to significant low values of Na+:K+ ratios in lowland plants. Better root functioning was, in turn, related with more consistent shoot performance as lowland plants maintained plant tiller number and shoot relative growth rate unaltered while upland plants decreased both parameters by 35 and 18%, respectively, when in saline flooding. The superior performance of lowland plants indicates that locally adapted populations can be promoted in salt marsh habitats with subtle differences at topographic level.","palabras_clave":"SALT MARSH|TILLERING|Na+\/K+ RATIO|AERENCHYMA|LEAF GAS EXCHANGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":94,"idioma_id":4,"titulo":"Postnatal behavioral and inflammatory alterations in female pups prenatally exposed to valproic acid","resumen":"In Autism Spectrum Disorders (ASD), a bias to a higher incidence in boys than in girls has been reported. With the aim to identify biological mechanisms acting in female animals that could underlie this bias, we used an extensively validated mouse model of ASD: the prenatal exposure to valproic acid (VPA). We found postnatal behavioral alterations in female VPA pups: a longer latency in righting reflex at postnatal day (P) 3, and a delay in the acquisition of the acoustic startle response. We also analyzed the density of glial cells in the prefrontal cortex, hippocampus and cerebellum, in VPA and control animals. Female VPA pups showed alterations in the density of astrocytes and microglial cells between P21 and P42, with specific dynamics in each brain region. We also found a decrease in histone 3 acetylation in the cerebellum of female VPA pups at P14, suggesting that the changes in glial cell density could be due to alterations in the epigenetic developmental program. Finally, no differences in maternal behavior were found. Our results show that female VPA pups exhibit behavioral and inflammatory alterations postnatally, although they have been reported to have normal levels of sociability in adulthood. With our work, we contribute to the understanding of biological mechanisms underlying different effects of VPA on male and female rodents, and we hope to help elucidate whether there are factors increasing susceptibility to ASD in boys and\/or resilience in girls.","palabras_clave":"AUTISM|FEMALE|NEUROINFLAMMATION|HISTONE ACETYLATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":95,"idioma_id":4,"titulo":"Epidemiological and virological findings during multiple outbreaks of equine influenza in South America in 2012","resumen":"Background: In 2012, equine influenza (EI) virus was confirmed asthe cause of outbreaks of respiratory disease in horses throughoutSouth America. In Uruguay and Argentina, hundreds of vaccinatedthoroughbred horses in training and racing facilities were clinicallyaffected.Objective: To characterise the EI viruses detected during theoutbreak in Uruguay and Argentina.Methods: Virus was detected in nasopharyngeal swabs by a panreactiveinfluenza type A real-time RT-PCR. The nucleotidesequence of the HA1 gene was determined and analysedphylogenetically using MEGA 5 software. Amino acid sequencesalignments were constructed and virus was antigenicallycharacterised with specific ferret antisera. Paired serum sampleswere tested by haemagglutination inhibition and single radialhaemolysis.Results: The diagnosis of EIV was confirmed by real-time RT-PCR,virus isolation and serological testing. The phylogenetic analysis ofHA1 gene sequences of 18 EI viruses indicated that all of thembelong to clade 1 of the Florida sublineage of the American lineageand are closely related to viruses isolated in the United States in2012. The HA1 of viruses identified in horses in racing facilities inMaroñas, Uruguay, and in Palermo, Argentina, displayed 100%amino acid sequence identity and were identical to that of a virusisolated in Dubai in 2012, from vaccinated endurance horsesrecently imported from Uruguay.Conclusions: The surveillance data reported illustrate theinternational spread of EI viruses and support therecommendations of the OIE expert surveillance panel to includeviruses of the Florida sublineage in vaccines.","palabras_clave":"ARGENTINA|INFLUENZA|EQUINA|HEMAGLUTININA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":97,"idioma_id":4,"titulo":"Characterization of a new Helicoverpa armigera nucleopolyhedrovirus variant causing epizootic on a previously unreported host, Helicoverpa gelotopoeon (Lepidoptera: Noctuidae).","resumen":"This paper reports the first biological and molecular characterization of a nucleopolyhedrovirus isolated from the soybean and cotton pest Helicoverpa gelotopoeon. Studies were performed following a virus outbreak in a rearing facility and in wild H. gelotopoeon populations in Córdoba, Argentina. Host identity was corroborated by partial sequencing of the COI gene. Scanning electron microscope observations of purified OBs revealed their polyhedral morphology and an average diameter of 0.89 ± 0.14 &#956;m. Ultrathin sections of infected larvae examined by transmission electron microscopy showed the intranuclear occurrence of polyhedra and virus particles in fat body cells. Nucleocapsids were singly enveloped. Phylogenetic analysis of lef-8, lef-9, polh, orf5\/5b and hr3-orf62 viral sequences identified this new NPV isolate (hereafter HegeSNPV) as a variant of Helicoverpa armigera nucleopolyhedrovirus (HearNPV). Furthermore, HegeSNPV was closely related to the so-called ?HzSNPV Group? within HearNPV, although having particular characteristics.","palabras_clave":"Helicoverpa armigera |Helicoverpa gelotopoeon|nucleopolyhedrovirus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":101,"idioma_id":5,"titulo":"Análisis de las actividades de la cadena de valor de pymes del sector minerales no metálicos","resumen":"En Argentina existen unas60.000 PyMEs industriales, pilares de la economía, aportando a la generación deempleo y en la diversificación productiva. Sin embargo, tales empresasenfrentan dificultades para adaptarse al entorno, afectando su competitividad ysustentabilidad en el mercado.En este contexto, el presentetrabajo tiene como objetivo conocer la situación actual de un conjunto de PyMEsde Olavarría, respecto al grado de desarrollo y nivel de madurez de lasactividades pertenecientes a sus cadenas de valor, en pos de obtener unacaracterización del estado competitivo de las mismas.La herramienta de análisis utilizadaes la cadena de valor de Porter, complementada con el enfoque basado enrecursos. La recopilación de informaciónse realiza a través de la aplicación de dos instrumentos que indagan lascaracterísticas, el uso de recursos relacionados con las actividades primariasy de soporte y su nivel de madurez en términos de competitividad. Como resultado se obtiene quelas actividades destacadas a nivel general respecto a su grado de desarrolloson Operaciones y Marketing y ventas, con porcentajes superiores al 60. Encontrapartida, Logística de salida revela los valores más bajos de desarrollopor una característica intrínseca del sector. Analizando el sector, el estratovidrio expone un predominio en su grado de desarrollo, para actividadesprimarias y soporte, mientras que el estrato cal presenta los valores másbajos. Respecto al nivel de madureztodas las actividades manifiestan un nivel 2, uso ineficiente de recursos, evidenciandoun inadecuado uso de recursos para realizar las actividades dificultando ellogro de ventajas competitivas.","palabras_clave":"cadena de valor|enfoque basado en recursos|pymes|competitividad"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":103,"idioma_id":4,"titulo":"The thyroid hormone Triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity","resumen":"Dendritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced ability to stimulate cytotoxic T-cell responses with implications in DC-based immunotherapy","palabras_clave":"triiodothyronina|dendritic cell|immunotherapy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":104,"idioma_id":4,"titulo":"Salt mixtures induce anatomical modifications in the halophyte Prosopis strombulifera (Fabaceae: Mimosoideae).","resumen":"Plant morphology, anatomy, ultra-structure and metabolism are deeply affected by salt stress. Although salt mixtures occur naturally in soils there are few studies considering their effect in plant salt tolerance, particularly in halophytes. The aim of the present study was to determine the effects of the salt mixture Na2SO4 + NaCl at different concentrations on the anatomy of Prosopis strombulifera, and to compare them with the responses observed earlier in iso-osmotic monosaline cultures. Seedlings were grown hydroponically in Hoagland?s solution adding salt pulses of NaCl + Na2SO4 (25 mM L&#8722;1 and 19 mM L&#8722;1, respectively), every 48 h until final &#936;o values of &#8722;1, &#8722;1.9, and &#8722;2.6 MPa. Control plants were grown under unsalted conditions. The salt-mixture also induced anatomical and histological alterations in roots, stems and leaflets in comparison with control plants and monosaline treated plants. These changes were noticeable from &#936;o = &#8722;1.9 MPa. Reduction in cortical tissues in roots and stems, and reduction in the mesophyll thickness were observed in treated plants, as well as lower number of leaflets. The different degrees of anatomical modifications were dependent on the organ\/tissue analyzed and could be particularly attributed to the presence of Cl&#8722; or SO42&#8722; in the culture medium. Some of them developed features intermediate between those observed in monosaline (NaCl or Na2SO4) treated plants, in agreement with the reversion of the toxic effect of SO42&#8722; anion on plant growth under iso-osmotic salt-mixture. We propose that plant anatomical modifications are responses correlated with the chemical nature of the ions present in the medium. When Cl&#8722; and SO42&#8722; are simultaneously present in the solution, ionic interactions occur determining specific responses which differ in their degree or intensity from those caused by monosaline solutions.","palabras_clave":"Prosopis|stress|antioxidants|hormones"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":105,"idioma_id":4,"titulo":"High diversity of human polyomaviruses in environmental and clinical samples in Argentina: Detection of JC, BK, Merkel-cell, Malawi, and human 6 and 7 polyomaviruses","resumen":"New human polyomaviruses have been recently described. The aim of this work was to detect and characterize human polyomaviruses circulating in Argentina by recovering viruses from environmental and sewage samples and evaluating their potential role as viral indicators of human waste contamination. Analysis was performed in a wider context including viruses from clinical samples from an immunocompromised population. River water and sewage samples were analyzed as a strategy to study the molecular epidemiology of viruses excreted by millions of people. Samples belonged to the Matanza-Riachuelo River (2005-2006: n=25 and 2012: n=20) and sewage from Buenos Aires city and suburbs (2011 and 2013: n=24). Viral detection was performed by PCR and the amplified viral genomes were characterized by phylogenetic analysis. Polyomaviruses were detected in 95.8% of sewage samples, identifying BKPyV (87.5%), JCPyV (83.3%), MCPyV (8.3%) and HPyV6 (8.3%). Besides, one sample collected in 2009 resulted positive for HPyV7. In 2005-2006, polyomaviruses were detected in 84.0% of river water samples, with the highest detection for MCPyV (52.0%), followed by BKPyV (44.0%), JCPyV (20.0%) and MWPyV (4.0%). In 2012, polyomaviruses were detected in 85.0% of river samples, finding JCPyV (85.0%), BKPyV (75.0%), MCPyV (25.0%) and HPyV6 (25.0%). Also, polyomaviruses, including JCPyV, BKPyV and MCPyV, were detected in 63.2% of urine samples from patients infected with HIV (n=19). Characterization indicated the coexistence of different genotypes and variants for each virus, particularly in sewage. MCPyV sequences (the only sequences from Argentina) formed a monophyletic group with the single sequence available for South America (French Guiana). The high level of detection and viral diversity found by environmental surveillance, which involved the characterization of viruses not previously described in South America, reinforces the usefulness of this approach to monitor viral contamination and describe the viral epidemiology in the general population.","palabras_clave":"POLYOMAVIRUS|ARGENTINA|ENVIRONMENTAL SURVEILLANCE|VIRAL CONTAMINATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":106,"idioma_id":4,"titulo":"A reassessment of the taxonomic status of Paraglyptodon Castellanos, 1932 (Mammalia, Cingulata, Glyptodontia)","resumen":"Castellanos described and published about new genera of glyptodonts, according to a phylogenetic scheme mainly based on the evolution of the external surface of the dorsal carapace. Among these new genera, Castellanos proposed Paraglyptodon as the predecessor of Glyptodon, and included within Paraglyptodonall known species of Glyptodontinae recovered from ?horizontes pre- ensenadenses?, and within Glyptodon all known species from ?Horizontes pampeanos?, restricting the latter to the Quaternary. All the species that belong to Paraglyptodon, that is Paraglyptodon chapalmalensis, Paraglyptodonuquiensis, Paraglyptodon dubius, and Paraglyptodon paranensis were established based on one, two or few osteoderms, mostly from the dorsal carapace. Regarding P. paranensis and P. dubius, Oliva and collaborators consider the first as a nomen vanum, representing an indeterminate Glyptodontinae, and the second as a synonym of P. chapalmalensis. Upon re-examination of the holotypes of P. chapalmalensis and P. uquiensis together with their comparison with other well-known specimens of glyptodonts, mainly with Glyptodon (of both juvenile and adult stages), we found the same ornamentation in different sections of the dorsal carapaces, particularly in P. chapalmalensis and in juvenile stages of Glyptodon spp.We could not identify features that would allow us to make a distinction between the holotype of P. uquiensis and Glyptodon spp. Therefore, we consider that a new taxon guide for naming the Upper Chapadmalalan biozone is necessary. The biostratigraphic range of Glyptodon could possibly be extended to the late Pliocene. However, new records and studies.","palabras_clave":"OSTEODERM|PARAGLYPTODON|GLYPTODON|GLYPTODONTIDAE|UQUIENSE |CHAPADMALALAN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":107,"idioma_id":4,"titulo":"Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs","resumen":"AbstractTo assess the effect of a single supraphysiological postnatal administration of a progestagen on uterine glands in dogs, 10 females were randomly assigned to: Medroxyprogesterone acetate 35 mg (MPA; n=6) or Placebo (n = 4) within the first 24 h of birth. The safety of the treatment was also evaluated. A transient mild clitoris enlargement appeared in MPA-treated females. Microscopic postpubertal uterine assessment revealed the presence of uterine glands in all the cases without significant differences in the area occupied by the glands per µm2 of endometrium nor in the height of the uterine epithelium.","palabras_clave":"canid|contraception|endocrine disruption|genital tract|neonatal"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":109,"idioma_id":4,"titulo":"Multiscale formulation for material failure accounting for cohesive cracks at the macro and micro scales","resumen":"ne'&gt;This contribution presents a two-scale formulation devised to simulate failure in materials with heterogeneous micro-structure. The mechanical model accounts for the nucleation of cohesive cracks in the micro-scale domain. The evolution and propagation of cohesive micro-cracks can induce material instability at the macro-scale level. Then, a cohesive crack is nucleated in the macro-scale model which considers, in a homogenized sense, the constitutive response of the intricate failure mode taking place at the smaller lengthscale.The two-scale semi-concurrent model is based on the concept of Representative Volume Element (RVE).&nbsp; It is developed following an axiomatic variational structure. Two hypotheses are introduced in order to build the foundations of the entire theory, namely: (i) a mechanism for transferring kinematical information from macro-to-micro scale along with the concept of ?Kinematical Admissibility?, and (ii) a Multiscale Variational Principle of internal virtual power equivalence between the involved scales of analysis. The homogenization formulae for the generalized stresses, as well as the equilibrium equations at the micro-scale, are consequencesof the variational statement of the problem.The present multiscale technique is a generalization of a previous model proposed by the authors [1, 2] and could be viewed as an application of a recent contribution [3]. The main novelty in this article lies on the fact that failure modes in the micro-structure involve a set of multiple cohesive cracks, connected or disconnected, with arbitrary orientation, conforming a complex tortuous failure path. Following the present multiscale modeling approach, the tortuosity effect is introduced as a kinematical concept and has a directconsequence in the homogenized mechanical response.Numerical examples are presented showing the potentialities of the model to simulate complex and realistic fracture problems in heterogeneous materials. In order to validate the multiscale technique in a rigorous manner, comparisons with the so-called DNS (Direct Numerical Solution) approach are also presented.","palabras_clave":"semi-concurrent multiscale model|material failure|crack path tortuosity|homogenization of traction-separation law|heterogeneous materials"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":110,"idioma_id":4,"titulo":"NDVI patterns as indicator of morphodynamic activity in the middle Paraná River floodplain","resumen":"This work assesses the performance of a 2000-2014 NDVI-MODIS time-series to identify areas of the Paraná River floodplainassociated with different morphodynamic areas and hence ecological behavior.From classification procedures we obtained six NDVI patterns (P1 to P6) differing in their mean values, standard deviation, and seasonality. The NDVIpatterns are evidence of different situations in terms of elevation, flooddynamics, and vegetation physiognomies: P1 represents water bodies, P2 to P4 cover frequently flooded lowlands colonized by marshy vegetation, and P5 and P6are placed on middle and high elevations that are less flooded and also arecovered by tall vegetation (grassland and forest). Instead of differences amongthe six NDVI patterns, they showed a spatial arrangement that allowed theidentification of two parallel belts; belt I, formed by P2 to P4, is placedclose to the Paraná River and its connected branches; while belt II, formed by P5 and mainly P6, appears on the marginal floodplain far away from the mainchannels. The spatial arrangement of the two belts is similar to limitsfollowed by the morphodynamic areas of the Paraná fluvial system. More than 60% of the surface covered by P2 and P5 corresponds to low morphodynamic areaswhile nearly 70% of P6 matches with high morphodynamic areas. Through theirannual and interannual behavior, spatial arrangement, and relationship withmorphodynamic areas, the NDVI patterns allow the interpretation of lateralorganization of the Paraná River floodplain. This paper exploits the potentialof time-series of NDVI to understand, from a synoptic point of view, thefloodplain dynamics by capturing the seasonal and interannual variability ofvegetation physiognomies and hydrosedimentological regime along and across thefloodplain.","palabras_clave":"TIME-SERIES OF NDVI-MODIS|FLOODPLAIN MORPHODYNAMIC|LATERAL DIMENSION |PARANÁ RIVER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":112,"idioma_id":4,"titulo":"DEVELOPMENT OF A REAL-TIME PCR ASSAY FOR THE DETECTION OF TRICHINELLA SPIRALIS IN MUSCLE TISSUE OF SWINE AND DERIVATIVES","resumen":"Trichinellosis is an emergent zoonosis in several regions of the world and it isconsidered a public health problem. Trichinellosis represent one of the mostimportant zoonotic diseases in Argentina. The purpose of this study was todevelop a real-time PCR assay with internal control to detect Trichinella spiralisDNA in samples of swine muscles and its derivatives. PCR amplification of DNAfrom muscle samples was performed by real-time PCR with an internal porcineDNA amplification control. The developed PCR assay specifically detects T. spiralisshowing no amplification with other Trichinella genotypes and showed anestimated sensitivity of 0.024 larvae per gram in swine muscle samples. From the21 samples analyzed, five samples negative by enzymatic digestion were positive byreal-time PCR, which demonstrates that this technique is capable of detecting T.spiralis in cases when enzymatic digestion cannot. In this work, a new molecularassay with internal control for T. spiralis detection was successfully developed.","palabras_clave":"Real time pcr|trichinella spiralis| muscle tissue"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":113,"idioma_id":4,"titulo":"Validation of UV-Visible and HPLC method for the determination of sodium p-aminosalicylate and m-aminophenol in a new pharmaceutical formulation","resumen":"Sodium p-aminosalycilate is an orphan drug used in patients affected with Multidrug-resistant Tuberculosis. Two methods, high-performance liquid chromatographic and UV spectrophotometric for the quantitative determination of sodium p-aminosalycilate and its degradation product m-aminophenol in a new pharmaceutical formulation, powder for extemporaneous reconstitution, were developed in the present work. The parameters linearity, precision, accuracy, specificity, robustness, limit of detection and limit of quantification were also studied. Chromatography was carried out by reverse-phase technique on an RP-18 column with a mobile phase composed of 50 mM monobasic\/dibasic phosphate buffer and methanol (42.5:42.5:15 v\/v\/v) with 1.9g of hidroxytetrabutylammonium ionic pare adjusted to pH 7.0 with orthophosphoric acid. The UV spectrophotometric method was performed at 254 nm and 280 nm for quantification of sodium p-aminosalycilate and m-aminophenol, respectively. The proposed methods are highly sensitive, precise and accurate and can be used for the reliable quantification of sodium p-aminosalycilate in the new alternative formulation. HPLC approach demonstrated to be stability-indicating method therefore is suitable for the investigation of the chemical stability of sodium p-aminosalycilate.","palabras_clave":"SODIUM P-AMONISALYCILATE|M-AMINOPHENOL|HPLC|UV SPECTROPHOTOMETRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":116,"idioma_id":4,"titulo":"Effect  of  humic  acid  on  the  adsorption\/desorption  behavior  of  glyphosate  on  goethite. Isotherms and kinetics","resumen":"The effects of humic acid (HA) on the adsorption\/desorption of glyphosate (Gly) on goethite were investigated under pseudo equilibrium conditions by adsorption isotherms and under kinetic conditions by ATR-FTIR spectroscopy. Isotherms reveal that the attachment of Gly is almost completely inhibited by HA molecules. The opposite effect is not observed: HA adsorption is not affected by the presence of Gly. ATR-FTIR allowed the simultaneous detection of adsorbed HA and Gly during kinetic runs, revealing that HA at the surface decreases markedly the adsorption rate of Gly likely as a result of a decreased availability of sites for Gly adsorption and because of electrostatic repulsion. In addition, HA in solution increases the desorption rate of Gly. The rate law for Gly desorption could be determined giving important insights on the desorption mechanism. The herbicide is desorbed by two parallel processes: i) a direct detachment from the surface, which is first order in adsorbed Gly; and ii) a ligand exchange with HA molecules, which is first order in adsorbed Gly and first order in dissolved HA. Rate constants for both processes were quantified, leading to half-lives of 3.7 h for the first process, and 1.4 h for the second process in a 400 mg L1 HA solution. These data are important for modeling the dynamics of glyphosate in environmentally relevant systems, such as soils and surface waters.","palabras_clave":"glyphosate|humic acid|goethite|desorption"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":117,"idioma_id":4,"titulo":"Anisotropic Reversible Piezoresistivity in Magnetic-Metallic\/Polymer Structured Elastomer Composites: Modelling and Experiments","resumen":"Structured elastomeric composites (SECs) with electrically conductive fillers display anisotropic piezoresistivity. The fillers do not form string-of-particle structures but pseudo-chains formed by grouping micro-sized clusters containing nanomagnetic particles surrounded by noble metals (e.g. silver, Ag). The pseudo-chains are formed when curing or preparing the composite in the presence of a uniform magnetic field, thus pseudo-chains are aligned in the direction of the field. The electrical conduction through pseudo-chains is analyzed and a constitutive model for the anisotropic reversible piezoresistivity in SECs is proposed. Several effects and characteristics, such as electron tunnelling, conduction inside the pseudo-chains, and chain-contact resistivity, are included in the model. Experimental results of electrical resistance, R, as a function of the normal stress applied in the direction of the pseudo-chains, P, are very well fitted by the model in the case of Fe3O4[Ag] microparticles magnetically aligned while curing in polydimethylsiloxane, PDMS. The cross sensitivity of different parameters (like the potential barrier and the effective distance for electron tunnelling) is evaluated. The model predicts the presence of several gaps for electron tunnelling inside the pseudo-chains. Estimates of those parameters for the mentioned experimental system under strains up to 20% are presented. Simulations of the expected response for other systems are performed showing the influence of Young´s modulus and other parameters on the predicted piezoresistivity.","palabras_clave":"elastomeric composites|piezoresistivity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":119,"idioma_id":4,"titulo":"?Thalidomide analogues: Tumor necrosis factor-alphainhibitors and their evaluation as anti-inflammatory agents.?","resumen":"A series of related thalidomide derivatives (2?9) were synthesized by microwave irradiation and evaluated for anti-inflammatory activity. Such activity was assessed in vivo and ex vivo. Compounds 2, 8 and 9 showed the highest levels of inhibition of TNF-&#945; production. On rat paw edema and hyperalgesia assays, compound 9, (1,4-phthalazinedione) demonstrated the highest in vivo anti-inflammatory activity. Thus, compound 9 can be considered as a promising compound to be subjected to further modification to obtain new agents for the treatment of inflammatory diseases.","palabras_clave":"Phthalimides|TNF-&#945;|Phthalazinone derivate| Anti-inflammatory effect"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":121,"idioma_id":4,"titulo":"Implications of the diversity of conceptual and operational definitions of poverty on cognitive development","resumen":"Ver en archivo adjunto","palabras_clave":"POBREZA INFANTIL|DESARROLLO COGNITIVO|INDICADORES DE POBREZA|NEUROCIENCIA COGNITIVA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":122,"idioma_id":4,"titulo":"Metastatic breast cancer patients treated with low dose metronomic chemotherapy with cyclophosphamide and celecoxib. Clinical outcomes and biomarkers of response","resumen":"BACKGROUND:Preclinical results showing therapeutic effect and low toxicity of metronomic chemotherapy with cyclophosphamide (Cy) + celecoxib (Cel) for mammary tumors encouraged its translation to the clinic for treating advanced breast cancer patients (ABCP).PATIENTS AND METHODS:A single-arm, mono-institutional, non-randomized, phase II, two-step clinical trial (approved by Bioethics Committee and Argentine Regulatory Authority) was designed. Patients received Cy (50 mg po.d) + Cel (200 mg p.o.bid). Patient eligibility criteria included: ABCP who progressed to anthracyclines, taxanes and capecitabine, &#8804;4 chemotherapy schemes, with good performance status. Several pro- and anti-angiogenic molecules and cells were determined as biomarkers. Informed consent was signed by all patients. Primary endpoint was clinical benefit (CB).RESULTS:Twenty patients were enrolled. Main clinical outcomes were prolonged disease stabilization and partial remission in 10\/20 and 1\/20 patients, respectively. CB was 55 %, and time to progression (TTP) was 21.1 weeks. Median TTP in patients who achieved CB was 35.6 weeks, and mean overall survival was 44.20 weeks. There were no grade 3\/4 toxicities associated with treatment. Circulating endothelial cells (CECs) increased at the time of progression in patients who showed CB (P = 0.014). Baseline CECs and circulating endothelial progenitor cells showed marginal associations with TTP. Serum VEGF decreased (P = 0.050), sVEGFR-2 increased (P = 0.005) and VEGF\/sVEGFR-2 ratio decreased during treatment (P = 0.041); baseline VEGF and VEGF\/sVEGFR-2 were associated with TTP (P = 0.035 and P = 0.030, respectively), while sVEGFR-2 did not.CONCLUSIONS:Treatment was effective, showing low toxicity profile and excellent tolerability. The combination had anti-angiogenic effect. Increased levels of CEC could be useful for detecting progression. Baseline VEGF and VEGF\/sVEGFR-2 values could be useful as early predictors of response.","palabras_clave":"METRONOMIC CHEMOTHERAPY|BIOMARKERS|CYCLOPHOSPHAMIDE|CELECOXIB"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":123,"idioma_id":4,"titulo":"Soybean Gly m Bd 30K\/P34 triggers a hypersensibility response in a mouse model of cow?s milk allergy","resumen":"Purpose: Soy-based formulas are widely used as dairy substitutes to treat milk allergy patients. However, reactions to soy have been reported in a  small proportion of patients with IgE-mediated milk allergies. The aim of this work was to explore whether P34, a mayor soybean allergen, is involved  in this cross-reactivity. Methods: In vitro recognition of P34 was evaluated by immunoblotting, competitive ELISA and basophil activation  tests (BAT) using sera from allergic patients. In vivo cross-reactivity was examined using an IgE-mediated milk allergy mouse model. Results: P34  was recognized by IgE antibodies from the sera of milk allergic patients, casein-specific monoclonal antibodies, and sera from milk-allergic mice.  Spleen cells from sensitized mice incubated with milk, soy or P34 secreted IL-5 and IL-13, while IFN-&#947; remained unchanged. In addition, the cutaneous  test was positive with cow?s milk proteins (CMP) and P34 in the milk allergy mouse model. Moreover, milk-sensitized mice developed immediate  symptoms following sublingual exposure to P34. Conclusions: Our results demonstrate that P34 shares epitopes with bovine casein, which is responsible  for inducing hypersensitivity symptoms in milk allergic mice. This is the first report of the in vivo cross-allergenicity of P34.","palabras_clave":"food allergy|soybean|p34 protein|cross-reactivity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":124,"idioma_id":5,"titulo":"Estudio del margen continental argentino para la determinación del límite entre corteza oceánica y continental (desde 40ºS hasta 44ºS) a partir de métodos geomagnéticos","resumen":"Marine magnetic data from global grids were analyzed in order to obtain a digital map of magnetic anomaliesin the Argentine continental margin between latitudes 40° and 44°S. These data were mathematically filteredto assist in the characterization of regional domains and magnetic boundaries. In particular, we have analyzedthe frequency and amplitude of the filtered data of magnetic anomalies. The interpretation of the filteredmagnetic field has been compared to a gravimetric 2D model. The study of the filtered magnetic anomaliesprofile allowed the determination of the limits of the continental-oceanic crust (COB, continental-oceanicboundary) providing interesting contributions to the understanding of the formation of the margin andreaffirming its characteristics of volcanic activity, shown through variations of the magnetic susceptibility.","palabras_clave":"CORTEZA OCEÁNICA Y CONTINENTAL|MARGEN CONTINENTAL ARGENTINO|MÉTODOS GEOMAGNÉTICOS|Borde continental oceánico (COB)"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":125,"idioma_id":4,"titulo":"Straylight and visual quality on early nuclear and posterior subcapsular cataracts","resumen":"PURPOSE: To measure log(s) and OSI parameters, both related to forward light scattering in the eye, in subjects with different kinds of early cataracts -nuclear or posterior subcapsular- and corrected visual acuity (CVA). METHODS: 34 eyes of 19 patients ranged between 50 and 75 years old with diagnosed nuclear (14 eyes) or posterior subcapsular cataract (20 eyes) were recruited. Only NO1, NO2, P1 and P2 opacity scores according to LOCS III were included. Observer examination included visual acuity, contrast threshold (Ct), and measurements performed by straylightmeter (straylight parameter log(s)) and double-pass instrument (objective scatter index (OSI)).RESULTS: OSI and log(s) was correlated with LOCSIII in nuclear opacities (P=0.015 and 0.004, respectively) and in the whole data (P=0.027 and 0.019, respectively) but did not for posterior subcapsular opacities alone. OSI was strongly correlated with log(s) in nuclear (r=0.885 and P<0.001) but not in posterior subcapsular cases (r=0.382 and P=0.097). Ct was correlated with log(s) for both cataract types (P=0.043 for nuclear and P=0.005 for posterior subcapsular cataract) but not with OSI (P=0.093 for nuclear and P=0.064 for posterior subcapsular cataract).CONCLUSIONS: OSI and log(s) discriminate early stages of nuclear cataracts when taking LOCS III as reference, so these opacities could be graded by any of those parameters. LOCSIII does not represent the visual condition for posterior subcapsular cataract. Straylightmeter measurements express the loss in contrast sensitivity caused by nuclear and posterior subcapsular opacities. Studies of lens opacities must be separated according to the type of opacity present in eyes.","palabras_clave":"STRAYLIGHT|VISUAL QUALITY|NUCLEAR AND POSTERIOR SUBCAPSULAR CATARACT|CONTRAST THRESHOLD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":127,"idioma_id":5,"titulo":"Potenciales áreas de cultivo de Melia azedarach L. en Argentina, productora de aceite para biodiesel y bioinsecticida","resumen":"El árbol del paraíso, Melia azedarach, se cultiva por sus hermosos racimos de flores púrpuras fragantes. La madera se utiliza para muebles y leña. Las hojas y los frutos tienen propiedades insecticidas. De sus bayas se puede extraer un aceite que sirve para elaborar biodiesel o bioinsecticida. En Argentina se introdujo como ornamental y se naturalizó con rapidez.  El objetivo de este estudio fue identificar las potenciales áreas de cultivo de esta especie, utilizando tierras que no son apropiadas para la producción de alimentos para producir aceite, ya sea para biodiesel o bioinsecticida.   Fue necesario identificar los requerimientos, los límites y la tolerancia de las condiciones biometeorológicas para esta especie, teniendo en cuenta las características climatológicas de las zonas nativas y regiones de cultivo exitoso en todo el mundo. Se utilizaron los datos de precipitación media anual y de temperatura para el período 1981-2010, de todas las estaciones meteorológicas y agrometeorológicas presentes en el país. La superposición de los mapas de temperatura y de precipitación permitió obtener el mapa de aptitud agroclimática y delimitar áreas óptimas, muy apropiadas, apropiadas, marginales y no aptas. Las áreas clasificadas desde el punto de vista agroclimático como óptima y muy apropiadas presentan clima húmedo y subhúmedo-húmedo. En base a literatura consultada, bajo esas condiciones la especie ha manifestado un comportamiento invasor. Por lo tanto, el cultivo con fines energéticos deberá relegarse a climas subhúmedo-secos. En climas húmedos se recomienda la forestación con paraíso solo en aquellas tierras que necesitan rehabilitación, por presentar problemas de erosión hídrica","palabras_clave":"Melia azedarach|necesidades bioclimáticas|zonificación agroclimática|biodiesel"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":128,"idioma_id":4,"titulo":"Role of Cr(III) deposition during the photocatalytic transformation of hexavalent chromium and citric acid over commercial TiO2 samples","resumen":"Removalof Cr(VI) and citric acid (Cit) by heterogeneous photocatalytic Cr(VI)transformation under UV light over two commercial TiO2 samples (1 gL&#8722;1), Evonik P25 and Hombikat UV100, was studied at pH 2 and Cr(VI)concentrations between 0.2 and 3 mM, with a fixed [Cit]0\/[Cr(VI)]0molar ratio (MR) of 2.5. In both cases, up to complete Cr(VI) removal, the temporalprofiles of Cr(VI) and Cit were well adjusted to a pseudo-first order rate lawwith the same rate constant, evidencing that Cr(VI) removal controls thekinetics of the system. Once Cr(VI) is fully removed, Cit degradation continueswith a Langmuir-Hinshelwood behaviour. In all cases, the rate constantsdecreased with increasing [Cr(VI)]0, and time resolved microwaveconductivity (TRMC) measurements revealed that its was due to an increasing retentionof Cr(III) on the surface of the photocatalysts, which reduces the lifetime ofthe electrons. Bothkinetic experiments and TRMC measurements confirm that UV100 is not only moreefficient than P25 for Cr(VI) and Cit removal, but it is also less influencedby the poisoning of the surface, consistently with its larger specific area. The use of Cit as the sacrificial agent improvesthe rate and efficiency of the photocatalytic Cr(VI) removal, and also thestability of the photocatalyst by preventing Cr(III) deposition, due to theformation of soluble Cr(III)-complexes, envisaged as a general result of thepresence of oligocarboxylic acids in the photocatalytic Cr(VI) system","palabras_clave":"Chromium|Photocatalysis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":130,"idioma_id":5,"titulo":"Evaluación Genética de Reproductores Holando Argentino en el ámbito nacional","resumen":"A partir de 1998 la Asociación Criadores de Holando Argentino, mediante convenio con la Facultad de Ciencias Veterinarias de Tandil, introdujo la metodología BLUP Modelo Animal para la estimación de los valores genéticos para producción y tipo de los reproductores de la raza. Estos valores se publican anualmente en los meses de Febrero y Agosto.    Las ventajas sobresalientes de la obtención de valores genéticos mediante esta metodología son:  Permite la evaluación simultánea de toros y vacas; por lo tanto se tienen valores para las hembras de la población analizada.  Tiene en cuenta los apareamientos dirigidos. Es decir, que al calcular la prueba de un toro a partir de los datos de sus hijas se puede tener en cuenta cuál es el mérito genético de sus madres, corrigiendo así el hecho de que las mejores vacas se inseminen con los mejores toros.  Aumenta la precisión del valor genético al incluir las relaciones de parentesco","palabras_clave":"EVALUACIÓN GENÉTICA|MEJORAMIENTO ANIMAL|HOLANDO ARGENTINO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":132,"idioma_id":4,"titulo":"TiO2 thick films supported on stainless steel 1 foams and their photoactivity in the nonylphenol ethoxylate mineralization","resumen":"The main interest in employing a structured catalyst for water treatment processes is to avoid an extra recovering-step of the powder catalyst after concluding the treatment. For this purpose, TiO2 powder (Degussa P25) was immobilized onto metallic foam walls (TiO2-foam) through the washcoating method and its photocatalytic activity was evaluated in the degradation of nonylphenol ethoxylate (NP4EO), which is considered an endocrine disrupter. The morphological and physicochemical characteristics of TiO2 films were studied by X-Ray Diffraction, Laser Raman Spectroscopy and ScanningElectron Microscopy.The fast and easy washcoating method used in this work allowed the immobilization of the TiO2 powder onto a relatively inexpensive metallic substrate. The TiO2 layer was uniformly distributed, having a high adherence to the metallic foam walls, which were previously submitted to a passivation treatment. This pre-treatment hindered a further migration of cations from the foam core to the titania film and favored the subsequent film anchorage. Moreover, the catalytic film so obtained maintained the anatase and rutile phases with their original proportions, preserving the properties of the TiO2 powder. The photocatalytic activity of the TiO2-foam was similar to that of a commercial catalyst (TiO2-Ti mesh), i.e. both reduced the TOC of the NP4EO solution by about 91%, showing similar reaction kinetics and overall quantum yield (overall). These results demonstrate that by means of the method under study, TiO2 can be successfully immobilized without decreasing its photocatalytic activity. These catalysts may be applied in water\/wastewater treatment, reducing the process stages and the overall cost of the procedure.","palabras_clave":"TITANIUM OXIDE|HETEROGENEOUS PHOTOCATALYSIS|EMERGING CONTAMINANT|NONYLPHENOL ETHOXYLATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":134,"idioma_id":4,"titulo":"The structure of b-diketones related to curcumin determined by X-ray crystallography, NMR (solution and solid state) and theoretical calculations","resumen":"p { margin-bottom: 0.25cm; direction: ltr; color: rgb(0, 0, 0); line-height: 120%; }p.western { font-family: 'Times New Roman',serif; font-size: 12pt; }p.cjk { font-family: 'Times New Roman',serif; font-size: 12pt; }p.ctl { font-family: 'Times New Roman',serif; font-size: 12pt; }a:visited { color: rgb(128, 0, 128); }a.western:visited {  }a.cjk:visited {  }a.ctl:visited {  }a:link { color: rgb(0, 0, 255); }Structural data are reported on sixteen ketoenols of &#946;-diketones:solution NMR, solid-state NMR (CPMAS and MAS) and X-raycrystallography (eight compounds, where three are new). The emphasisis on the tautomerism between both ketoenols, in solution and in the solid statep { margin-bottom: 0.25cm; direction: ltr; color: rgb(0, 0, 0); line-height: 120%; }p.western { font-family: 'Times New Roman',serif; font-size: 12pt; }p.cjk { font-family: 'Times New Roman',serif; font-size: 12pt; }p.ctl { font-family: 'Times New Roman',serif; font-size: 12pt; }a:visited { color: rgb(128, 0, 128); }a.western:visited {  }a.cjk:visited {  }a.ctl:visited {  }a:link { color: rgb(0, 0, 255); }Structural data are reported in sixteen ketoenols of beta diketones, solution NMR, solid-state NMR(CPMAS and MAS) and X-ray crystallography (four compounds, where three are new). The emphasis is on the tautomerist between both ketoenols, both in solution and solid-state.  GIAO-B3LYP 6-311g (d,p)  and Quantum ESPRESSO (QE) calculations were used and compared. For average values, the GIAO-DMSO-PCM is enough but splittings can only be approached by using QE. A case of rotational disorder has been analyzed. Some anomalies related to C-F bonds and to the C-CF3 group have been detected.","palabras_clave":"NMR|GIAO\/B3LYP|QUANTUM ESPRESSO|CPMAS\/MAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":135,"idioma_id":5,"titulo":"Historia de la música y morfología musical. Algo más que una cuestión de formas.","resumen":"      En la Enseñanza Musical en el Nivel Superior, - aunque  también en la producción teórica sobre la música-, la confluencia de saberes  provenientes de diferentes campos epistémicos en un mismo corpus resulta  habitual. La superposición de la historia de la música y la morfología musical  es un caso frecuente. &nbsp;La musicología no  ha resuelto esta tensión, solapándose vertientes como la musicología histórica,  la teoría musical o la musicología sistemática.      Así, a la hora de definir periodizaciones se apela a  aspectos formales del repertorio canónico - usualmente el de Europa occidental-  en tanto criterio de agrupamiento. Esto se evidencia en la asociación de  estilos y formas musicales sintetizándose en taxonomías prototípicas como  Clasicismo y sonata para piano. Para ello, la forma musical es reducida a  esquema o fórmula, y cualquier música que presente alguna alteración es  entendida como argumento para su exclusión en el estudio.       Esta actitud conlleva la marginación de músicas  creadas bajo coordenadas históricas y culturales donde la práctica musical es  entendida como devenir en la que se inscriben, por ejemplo, gran parte de las  músicas populares.      La imposición de la forma como unidad de análisis en la  historia de la música explica la ausencia de ?otras? músicas que no responden al  canon formal, aún siendo contemporáneas y de mayor trascendencia en época. La  reproducción acrítica de estas ausencias en la formación profesional aporta a un  determinado imaginario social sobre la música. Este trabajo propone revisar el  rol de la morfología musical en este proceso.  ","palabras_clave":"Historia de la Música|Musicología|Morfología Musical"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":136,"idioma_id":5,"titulo":"SELECTIVE ATTENTION AND ERROR PRONENESS WHILE DRIVING: RESEARCH USING A CONJUNCTIVE VISUAL SEARCH TASK","resumen":"Selective attention is a fundamental ability for safe driving. The objective of this workwas to analyze the relationship between selective attention and a predisposition to experienceinattention errors while driving. Thirty drivers from the City of Mar del Plata, Argentina,participated in the study and completed a selective attention task (Conjunctive Visual SearchTask, CVST), and a driver inattention scale (Attention-related Driving Errors Scale, ARDES).Pearson correlations were calculated between the ARDES and the CVST performance measures(errors and reaction times). A consistent relationship was observed between CVST performance and the scores reported by the ARDES. Drivers with higher driver inattention proneness tended to commit a greater number of errors in target identification while also presenting lower reaction times. The results provide evidence of the possible role of selective attention in driver inattention, and illustrate the potential usefulness of a visual search measure in the area of driving assessment.Key words: selective attention, driver inattention, evaluation, Conjunctive Visual Search,road safety.","palabras_clave":"SELECTIVE ATTENTION |DRIVER INATTENTION |EVALUATION |CONJUNCTIVE VISUAL SEARCH |ROAD SAFETY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":137,"idioma_id":4,"titulo":"Generalized Predictive Current Control (GPCC) for Grid-Tie Three-Phase Inverters","resumen":"This work proposes a linear Generalized Predictive Current Control (GPCC) for Grid-Connected Voltage Source Inverters, which presents a fast response to current reference step changes, parameter variation robustness and low distortion at the output currents, with reduced computational effort. Experimental results on a 10 kW converter connected to a real grid are shown and the proposed controller is compared against a classical proportional resonant (PR) controller.","palabras_clave":"Generalized Predictive Control|Digital current controller|Grid-Tie Voltage-Source Inverters|Renewable Energy Systems"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":138,"idioma_id":4,"titulo":"Simultaneous generation and correlation of complete sets of generalized pairwise complementary sequences","resumen":"New coding schemes are increasingly being developed to adapt multisensor and communication systems to the requirements of the current technological environment. In some cases, the practical implementation of these schemes involves a great amount of signal processing operations. In order to achieve and make suitable their use in different platforms, efficient algorithms are required to process coding. In the last years, a new kind of complementary sequences, known as Generalized Pairwise Complementary sequences, has been proposed. These sequences provide high noise immunity when they are applied to multiuser systems, as well as a low cross-correlation, which is convenient in those applications. The aim of this paper is to propose optimized generation and correlation architectures for Generalized Pairwise Complementary sequences that would allow to process a complete set using a reduced amount of operations. An analytical demonstration is provided, with a final comparison to evaluate the reduction with regard to other algorithms.","palabras_clave":"GPC sequences|Generation and correlation|Signal detection"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":140,"idioma_id":4,"titulo":"Changes in Coastal Benthic Algae Succession Trajectories and Assemblages Under Contrasting Nutrient and Grazer Loads","resumen":"Eutrophication plays a crucial role in coastal systems, driving changes in the composition and abundance of flora and fauna with consequent effects for the entire ecosystem. Sensitive to nutrient levels, micro- and macroalgal blooms serve as valuable indicators of eutrophication. The San Antonio Bay (Northern Argentinean Patagonia, 40° 43&#8242; S, 64° 56&#8242; W) provides an appropriate system to study in situ eutrophication processes on coastal communities. In a multiscale approach, using two different kind of settlement substrates (micro: polyethylene terephthalate, and macro: ceramic), the present study followed benthic algal dynamics over one year, distinguishing changes in natural succession and seasonality. Strong differences were found in the biofilm assemblagesafter three days, marked by tube dwelling diatoms and Cocconeis spp. under high nutrient-grazer conditions and needle like diatoms (e.g. Nitzschia spp., Tabularia spp.) under lower nutrient-grazer loads. The succession continued by thecolonization of macroalgae, with a higher recruitment rate inthe nutrient and grazer rich environment with a concomitant higher diversity. Our results show that under higher nutrientgrazer conditions natural benthic succession not only differs in trajectory but in its final taxa composition promoting higher biodiversity and biomass accumulation. In addition,taxa specific substrate preferences interfere with the observed eutrophication pattern, suggesting substrate dependant interrelations between the bloom forming taxa. These findings provide evidence that nutrient enrichment can not only affect an established assemblage but also affect theearly succession stages, changing the succession trajectory and thus the final assemblage.","palabras_clave":"NUTRIENTS |GRAZERS|EPIBENTHOS|ALGAE|SUCESSION|INTERTIDAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":142,"idioma_id":4,"titulo":"Reduced vasopressin receptors activation mediates the anti-depressant effects of fluoxetine and venlafaxine in bulbectomy model of depression","resumen":"Rationale: In response to stress, corticotropin releasing hormone (CRH) andvasopressin (AVP) are released from the hypothalamus, activate their receptors(CRHR1, CRHR2 or AVPr1b), and synergistically act to induce adrenocorticotropichormone (ACTH) release from the anterior pituitary. Overstimulation of this system has been frequently associated with major depression states.Objective: to assess the role of AVP and CRH receptors in fluoxetine and venlafaxineeffects on the expression of depression-related behavior.Methods: In an animal model of depression (olfactory bulbectomy in mice, OB) weevaluated the effects of fluoxetine or venlafaxine (both 10 mg\/kg\/day) chronicadministration on depression-related behavior in the tail suspension test. Plasma levels of AVP, CRH and ACTH were determined as well as participation of their receptors in the expression of depression related-behavior and gene expression of AVP and CRHreceptors (AVPr1b, CRHR1 and CRHR2) in the pituitary gland.Results: The expression of depressive-like behavior in OB animals was reversed by treatment with both antidepressants. Surprisingly, OB-saline mice exhibited increased AVP and ACTH plasma levels, with no alterations in CRH levels when compared to sham mice. Chronic fluoxetine or venlafaxine reversed these effects. In addition, a significant increase only in AVPr1b gene expression was found in OB-saline.Conclusion: The antidepressant therapy used seems to be more likely related to areduced activation of AVP rather than CRH receptors, since a positive correlation between AVP levels and depressive-like behavior was observed in OB animals. Furthermore a full restoration of depressive behavior was observed in OB-fluoxetine or venlafaxine treated mice only when AVP was centrally administered but not CRH.","palabras_clave":"vasopressin|corticotrophin|olfactory bulbectomy|fluoxetine"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":143,"idioma_id":4,"titulo":"A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin","resumen":"The determination of the dissociation constant of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin was carried out by means of capillary electrophoresis using a dynamic coating of a fused-silica capillary with high-molecular-mass poly(diallyldimethylammonium chloride) (PDDA) implementing two methods: (a) fitting the effective mobility determined from different electrophoretic runs at a single wavelength as a function of pH and (b) a novel modeling strategy of the spectrophotometric.  Second order data generated with the diode array detector at several wavelengths as a function of pH. The accuracy of the proposed methodologies was verified using robenidine as a model compound with known value of pKa.","palabras_clave":"NICARBAZIN|CAPILLARY ELECTROPHORESIS|AUGMENTED MULTIVARIATE CURVE RESOLUTION |SECOND-ORDER DATA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":144,"idioma_id":4,"titulo":"High density of the alien bryozoan Fenestrulina delicia in the fouling assemblage of a South American harbour (Argentina)","resumen":"The non-indigenous cheilostome bryozoan Fenestrulina delicia Winston, Hayward and Craig has been recorded for the first time in the southern hemisphere. It was found on experimental substrata submersed to study the fouling assemblage of Quequén Harbour (Argentina, southwest Atlantic), an estuarine environment. Its density on experimental panels was very high, reaching almost 5,000 colonies.m-2. The percentage of ovicellate colonies, however, was relatively low (mean±SD: 5.2±2.3 %, range: 1.6 - 9.9 %) due to the abundance of newly recruited zoaria. F. delicia was originally described for the Atlantic coast of the United States. It was later discovered in Alaska, Oregon and California, and has recently been reported as a highly invasive fouler along the Atlantic coasts of Europe. This species seems to have the potential to continue its dispersion by means of maritime traffic, or rafting on plastic debris, and become a stable component of this and neighbouring harbours in the area.","palabras_clave":"INTRODUCED SPECIES|BRYOZOA|FENESTRULINA DELICIA|ESTUARINE ENVIRONMENT|SOUTHWEST ATLANTIC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":145,"idioma_id":4,"titulo":"Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats","resumen":"Objectives The aim of the study was to describe the pharmacokinetics and predicted efficacy of meropenem afterintravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to cats at a single dose of 10 mg\/kg.Methods Five adult healthy cats were used. Blood samples were withdrawn at predetermined times over a12 h period. Meropenem concentrations were determined by microbiological assay. Pharmacokinetic analyseswere performed with computer software. Initial estimates were determined using the residual method andrefitted by non-linear regression. The time that plasma concentrations were greater than the minimum inhibitoryconcentration (T >MIC) was estimated by applying bibliographic MIC values and meropenem MIC breakpoint.Results Maximum plasma concentrations of meropenem were 101.02 &#956;g\/ml (Cp(0), IV), 27.21 &#956;g\/ml (Cmax, IM) and15.57 &#956;g\/ml (Cmax, SC). Bioavailability was 99.69% (IM) and 96.52 % (SC). Elimination half-lives for the IV, IM andSC administration were 1.35, 2.10 and 2.26 h, respectively.Conclusions and relevance Meropenem, when administered to cats at a dose of 10 mg\/kg every 12 h, is effectiveagainst bacteria with MIC values of 6 &#956;g\/ml, 7 &#956;g\/ml and 10 &#956;g\/ml for IV, IM and SC administration, respectively.However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen.","palabras_clave":"meropenem|pharmacokinetics|cats|parenteral"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":146,"idioma_id":4,"titulo":"STRUCTURAL AND MATERIAL MECHANICAL QUALITY OF FEMORAL SHAFTS IN RATS EXPOSED TO SIMULATED HIGH ALTITUDE FROM INFANCY TO ADULTHOOD'","resumen":"The growth of the body and bone mass and the mechanicalproperties of appendicular bone are impaired in immature rats exposed to different simulated high altitudes (SHA)(1850?5450 m) between the 32nd and the 74th days of postnatal life. Now, we report the effects of exposure to4100m on the above cited variables in female rats from infancy (age: 1 month) to adulthood (age: 8 months) todefine the occurrence of catch up and to establish whether the effects of altitude are transient or permanent. Theex vivo right femur was mechanically tested in three-point bending. Body weight and length, and structural (loads atyielding and fracture, and stiffness) and architectural (diaphyseal cross-sectional area, cortical area, and crosssectionalmoment of inertia) properties were measured at 2, 4, 6, and 8 months of exposure to SHA. The negativeinfluence of hypoxia on all variables was similar at different ages or, in other words, the difference among ages wasmaintained at any extent of hypoxia. Hypoxia did not affect the elastic modulus, thus suggesting that the mechanicalproperties of the bone tissue were maintained. Catch up did not occur. The resulting osteopenic boneremained appropriate to its mechanical function during the entire exposure to SHA.right femur was mechanically tested in three-point bending. Body weight and length, and structural (loads atyielding and fracture, and stiffness) and architectural (diaphyseal cross-sectional area, cortical area, and crosssectionalmoment of inertia) properties were measured at 2, 4, 6, and 8 months of exposure to SHA. The negativeinfluence of hypoxia on all variables was similar at different ages or, in other words, the difference among ages wasmaintained at any extent of hypoxia. Hypoxia did not affect the elastic modulus, thus suggesting that the mechanicalproperties of the bone tissue were maintained. Catch up did not occur. The resulting osteopenic boneremained appropriate to its mechanical function during the entire exposure to SHA.","palabras_clave":"biomechanics|altitude"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":149,"idioma_id":5,"titulo":"Asociación entre el estado nutricional y la presencia de caries. Estudio preliminar en ninos preescolares","resumen":"La caries es una enfermedad infecciosa, dondela dieta y la saliva tienen un rol primordial.Objetivo: estimar la asociación entre estadonutricional (EN), caries, tasa de flujo salival(TFS) y microorganismos cariogénicos.Metodología: se estudiaron 63 niños preescolares.Se determinó EN, presencia decaries, TFS (ml\/min) y microorganismos cariogénicos.Resultados: el 49% fue antropométricamenteadecuado (Ad), 29.4% sobrepeso (SP) y 21.6% obeso (Ob). El 67% de Ad y el 35% de SP + Obpresentaron caries. No se evidenció correlaciónentre EN y TFS (p= 0.5977). El recuento deStreptococcus del grupo mutans no difirió entregrupos, pero el de Lactobacillus acidophilus fuesignificativamente menor en obesos (p<0.05), aligual que la presencia de Candida spp (p<0.05).Conclusiones: los niños con sobrepeso y obesidadpresentaron significativamente menoscaries, sin correlación con tasa de flujo salival,pero con cambios significativos en la composiciónde la microbiota bucal.Palabras clave: caries, estado nutricional,saliva, microbiota bucal, preescolares.","palabras_clave":"Estado nutricional|Caries|Microorganismos cariogénicos|Preescolares"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":150,"idioma_id":4,"titulo":"Effectiveness of a 95 SNP panel for the screening of breed label fraud in the Chinese meat market","resumen":"Breed assignment has proved to be useful to control meat trade and protect the value of special productions. Meat-related frauds have been detected in China; therefore, 95 SNPs selected from the ISAG core panel were evaluated to develop an automated and technologically updated tool to screen breed label fraud in the Chinese meat market. A total of 271 animals from four Chinese yellow cattle (CYC) populations, six Bos taurus breeds, two Bos indicus and one composite were used. The allocation test distinguished European, Japanese and Zebu breeds, and two Chinese genetic components. It correctly allocated Japanese Black, Zebu and British breeds in 100, 90 and 89% of samples, respectively. CYC evidenced the Zebu, Holstein and Limousin introgression. The test did not detect CYC components in any of the 25 samples from Argentinean butchers. The method could be useful to certify Angus, Hereford and Japanese Black meat, but a modification in the panel would be needed to differentiate other breeds.","palabras_clave":"Breed|DNA|Fraud|Label|Meat|China"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":151,"idioma_id":5,"titulo":"Desarrollo de la Investigación sobre Variación Morfológica de Poblaciones Históricas Sudamericanas Utilizando Rasgos Dentales No Métricos","resumen":"El análisis de rasgos no métricos dentales ha logrado establecer relaciones biológicas de grupos humanos pasadosy actuales con un alto valor taxonómico. Aunque Sudamérica ha sido objeto de un número considerable de investigaciones sobrepoblamiento, migraciones y mestizaje, son relativamente pocos los estudios que han utilizado información de rasgos dentales para estefin, con las consiguiente ausencia de datos en amplias zonas geográficas. Se realizó una revisión sistemática de la literatura en MEDLINE,SciELO, REDALYC y LILACS, sin restricción de fecha de publicación. Se incluyeron artículos completos y disponibles primarios ysecundarios en español, inglés y portugués donde se realice el análisis de rasgos morfológicos dentales en poblaciones sudamericanascon un contexto histórico anterior al siglo XX. Los artículos seleccionados fueron evaluados por dos investigadores de manera independiente.La búsqueda arrojó 2210 artículos de los cuales 19 cumplieron los criterios de inclusión, a los que se agregaron 9 luego de unabúsqueda manual complementaria. Existe un desarrollo no equilibrado de la investigación sudamericana, tanto en el foco geográficodonde esta se realiza, como de los países y filiaciones de sus autores. Aunque se han logrado estandarizar los instrumentos de valoraciónde esos rasgos, se sugiere promover una profesionalización interdisciplinaria, el apoyo internacional de sus proyectos y el abordajeholístico de sus contenidos para potenciar la aplicabilidad de su valor taxonómico a poblaciones actuales.","palabras_clave":"ANTROPOLOGIA|ODONTOLOGIA|RASGOS MORFOLOGICOS|REVISION SISTEMATICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":155,"idioma_id":4,"titulo":"Ivermectin Pharmacokinetics, Metabolism, and Tissue\/Egg Residue Profiles in Laying Hens","resumen":"The goals were to determine the ivermectin (IVM) plasma pharmacokinetics, tissue and egg residue profiles, and in vitro metabolism in laying hens. Experiments conducted were (1) 8 hens were intravenously treated with IVM and blood samples taken; (2) 88 hens were treated with IVM administered daily in water (5 days) (40 were kept and their daily eggs collected; 48 were sacrificed in groups (n = 8) at different times and tissue samples taken and analyzed); (3) IVM biotransformation was studied in liver microsomes. Pharmacokinetic parameters were AUC = 85.1 ng·day\/mL, Vdss = 4.43 L\/kg, and T1\/2el = 1.73 days. Low IVM tissue residues were quantified with the highest measured in liver and skin+fat. IVM residues were not found in egg white, but significant amounts were quantified in yolk. Residues measured in eggs were greater than some MRL values, suggesting that a withdrawal period would be necessary for eggs after IVM use in laying hens.","palabras_clave":"IVERMECTIN|PLASMA PHARMACOKINETICS|EGG RESIDUES|TISSUE RESIDUE PROFILES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":156,"idioma_id":4,"titulo":"Nitric oxide metabolism in heart mitochondria","resumen":"Normal cardiac function is accomplished through a continuous energy supply provided by mitochondria. Heart mitochondria are the major source of reactive oxygen and nitrogen species: superoxide anion (O2-) and nitric oxide (NO). Mitochondrial NO production by mitochondrial NOS (mtNOS) is modified by metabolic state and shows an exponential dependence on &#61508;&#61561;. The interaction between mtNOS and complexes I and IV might be a mechanism involved in the regulation of mitochondrial NO production. NO exerts a high affinity, reversible and physiological inhibition of cytochrome c oxidase activity. A second effect of NO on the respiratory chain is accomplished through its interaction with ubiquinol-cytochrome c oxidoreductase. The ability of mtNOS to regulate mitochondrial O2 uptake and O2- and H2O2 productions through the interaction of NO with the respiratory chain is named mtNOS functional activity. Together, heart mtNOS allows NO to optimize the balance between cardiac energy production and utilization, and to regulate the steady state concentrations of other oxygen and nitrogen free radicals.","palabras_clave":"BIOENERGETICS|MITOCHONDRIAL NOS |COMPLEX III|mtNOS FUNCTIONAL ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":157,"idioma_id":4,"titulo":"Vaginal mucus from ewes treated with progestogen sponges affects quality of ram spermatozoa","resumen":"The use of intravaginal sponges (IS) to synchronize estrous onset in ewes provokes vaginitis, an increase in the vaginal bacterial load, and growth of bacterial species that are not present during spontaneous estrous behavior. The objective of the study was to compare the functional sperm parameters after incubating it with mucus collected from the vagina of ewes during spontaneous estrus or estrous synchronized with IS. Pooled spermatozoa were co-incubated with: (1) vaginal mucus collected from ewes in spontaneous estrus; (2) vaginal mucus collected from ewes in estrus pretreated with progestogen-impregnated IS; (3) synthetic mucus; and (4) medium without mucus as a control group. Sperm samples were evaluated after incubating it for 30 and 90 minutes. The number of colony-forming units (CFUs\/mL), pH, and osmolality were greater in the mucus collected from ewes treated with IS than from those untreated (P = 0.046; P < 0.0001, and P < 0.0001, respectively). The percentage of sperm with progressive motility was lower after incubation with vaginal mucus collected from estrous ewes treated with IS than in the other three treatments both, 30 and 90 minutes after incubation (P = 0.0009 and P < 0.0001, respectively). The sample incubated for 30 minutes with mucus from ewes treated with IS had a lower percentage of sperm with intact plasma membrane than all the other treatments (P < 0.0001). The percentage of sperm with functional membrane was significantly lower in the sample incubated for 30 minutes with vaginal mucus from ewes treated with IS than in the other three treatments (P < 0.0001). After 90 minutes, the percentage was still lower than that in the sample collected from ewes during their spontaneous estrus (P = 0.0005). The lowest percentages of sperm with acrosome damage were observed in sperm incubated with mucus collected from sheep in spontaneous estrus for 30 and 90 minutes (P < 0.0001 and P = 0.008, respectively). The percentage of apoptotic spermatozoa was greater in samples incubated during 30 minutes with vaginal mucus collected from ewes treated with IS than in the other three groups (P = 0.0005). The functionality and the viability of ram sperm is negatively affected by the cervical mucus of ewes pretreated with progestagen-impregnated IS used in estrous synchronization treatments. This may partially explain the decrease in conception rate obtained with treatments with IS.","palabras_clave":"INTRAVAGINAL SPONGE|ESTROUS SYNCHRONIZATION|SHEEP|SPERM VIABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":161,"idioma_id":4,"titulo":"Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca2 + release events in a rodent model of early stage diabetes: The arrhythmogenic substrate","resumen":"Background: Heart failure and arrhythmias occur more frequently in patients with type 2 diabetes (T2DM) than in the general population. T2DMis preceded by a prediabetic condition marked by elevated reactive oxygen species (ROS) and subclinical cardiovascular defects. Although multifunctional Ca2+ calmodulin-dependent protein kinase II (CaMKII) is ROS-activated and CaMKII hyperactivity promotes cardiac diseases, a link between prediabetes and CaMKII in the heart is unprecedented.Objectives: To prove the hypothesis that increased ROS and CaMKII activity contribute to heart failure and arrhythmogenic mechanisms in early stage diabetes.Methods?Results: Echocardiography, electrocardiography, biochemical and intracellular Ca2+ (Ca2+ i) determinations were performed in fructose-rich diet-induced impaired glucose tolerance, a prediabetes model, in rodents. Fructose-rich diet rats showed decreased contractility and hypertrophy associated with increased CaMKII activity, ROS production, oxidized CaMKII and enhanced CaMKII-dependent ryanodine receptor (RyR2) phosphorylation compared to rats fed with control diet. Isolated cardiomyocytes from fructose-rich diet showed increased spontaneous Ca2+ i release events associated with spontaneous contractions, which were prevented by KN-93, a CaMKII inhibitor, or addition of Tempol, a ROS scavenger, to the diet. Moreover, fructose-rich diet myocytesshowed increased diastolic Ca2+ during the burst of spontaneous Ca2+ i release events.Mice treatedwith Tempol or with sarcoplasmic reticulum-targeted CaMKII-inhibition by transgenic expression of the CaMKII inhibitory peptide AIP, were protected fromfructose-rich diet-induced spontaneous Ca2+ i release events, spontaneous contractions and arrhythmogenesis in vivo, despite ROS increases.Conclusions: RyR2 phosphorylation by ROS-activated CaMKII, contributes to impaired glucose tolerance-induced arrhythmogenic mechanisms, suggesting that CaMKII inhibition could prevent prediabetic cardiovascular complications and\/or evolution.","palabras_clave":"CaMKII|arrhythmias|diabetes|ryanodine receptors"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":164,"idioma_id":5,"titulo":"La Patagonia en perspectiva regional: un camino posible para una historiografía renovada","resumen":"(Indexada en Latindex, Handbook of Latin American Studies, Library of Congress; Biblioteca Hispánica, Agencia Española de Cooperación Internacional (AECI); Online Catalogs of Library of Congress, University of California, University of Texas, University of Florida, University of Berkeley, University of Pittsburg).Este texto pretende sintetizar los aportes que desde la investigación histórica regional se han realizado acerca de la Patagonia en los últimos años, permitiendo revisar antiguos mitos de la historiografía nacional acerca de la región y aportando miradas  más complejas y diversificadas, tanto las referidas al mundo indígena y a su funcionamiento, como a la supervivencia de los antiguos circuitos mercantiles con el área del Pacífico y a los diversos poblamientos que caracterizaron su ocupación. Asimismo, se mostrarán las formas particularmente tardías de penetración estatal en diversas cuestiones que demoraron la sostenida intención política de 'argentinizar' el territorio.","palabras_clave":"HISTORIA |REGIONAL|RENOVACION |HISTORIOGRAFICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":165,"idioma_id":5,"titulo":"'Setecientosmonos y la modernización de la crítica literaria argentina'","resumen":"El artículo presenta una lectura crítica de la colección completa de la revista Setecientosmonos, publicada en la ciudad de Rosario (Argentina) entre 1964-1967, y aún poco explorada por los lectores especializados.La hipótesis que orienta la lectura afirma que el ingreso de Nicolás Rosa, a fines de 1964, refunda la publicación.  Rosa convierte una revista de jóvenes inexpertos, sin contactos con el mundo literario, en otra, también de jóvenes, ansiosos por asumir posiciones intelectuales y acercamientos teórico-críticos a la literatura. Bajo su influencia, Setecientosmonos adquiere el carácter diferencial que la vuelve un episodio significativo del proceso de actualización teórica y modernización metodológica de la crítica literaria argentina. El artículo sitúa los propósitos juvenilistas de los fundadores de la revista, Juan Martini, Carlos Schork, Omar Pérez Cantón y Rubén Radeff, sus escasos vínculos iniciales con críticos y escritores locales, para luego evaluar los cambios suscitados con el ingreso de Rosa. El parágrafo titulado 'Literatura y política' parte del examen crítico del texto de Rosa dedicado a Cabecita negra (Jorge Álvarez, 1963), que introduce la preocupación política en la revista, continúa con lectura contextualizada de su nota sobre Jean Paul Sartre y analiza el repentino giro comprometido que anuncia la 'Carta de la dirección' en el número 5.  El parágrafo 'Modernización teórica y nueva crítica' presenta, en sus líneas generales, el interés por las nuevas tendencias críticas que introducen las colaboraciones de Rosa, sobre todo a partir del número 6, en el que se incorpora al staff de directores, y sitúa sus vínculos con los críticos universitarios jóvenes, miembros del equipo de Adolfo Prieto (María Teresa Gramuglio, Josefina Ludmer, Norma Desinano), a quienes invita a colaborar.","palabras_clave":"REVISTA SETECIENTOSMONOS|MODERNIZACION TEORICA|CRITICA LITERARIA ARGENTINA|NICOLAS ROSA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":166,"idioma_id":4,"titulo":"Structural opportunities and local challenges for Food and Nutritional Security: a prospective framework for the South Cone","resumen":"Abstract: According to the 2014 SOFIreport the UnitedNations Organization for Food and Agriculture (FAO) estimated that worldwideabout 805 million people are chronically hungry, and within the Latin America region the total number of people affected is 47 million. Certain geopolitical factors such as global competition for naturalresources, energy insecurity, population growth and environmental degradation, it is estimated that pose in the medium to long term greater challengesfor a safe and affordable food supply; but for many food producing countries are promising opportunities. In particular the Southern Cone countries as big producers of raw food materials have benefited from the rising price of agro-food commodities in the last decade, although locally risingfood prices has affected the purchasing power of the consumers. Economic growth and agricultural growth in particular are needed to reduce hunger and under-nutrition but are not enough. In this regard in order to improve food and nutritional security it should be integrated in the design of public policies variables to harness the structural opportunities presented and at the same time respond to certainlocal challenges, of national and provincial level, mainly related to health systems and specifically directed to food safety.","palabras_clave":"Food and Nutritional Security|Food Safety|Southern Cone"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":167,"idioma_id":4,"titulo":"Expression and localization of urokinase-type plasminogen activator Receptor in bovine cumulus-oocyte complexes","resumen":"Urokinase-type plasminogen activator (uPA) is a serine protease involved in extracellular matrix remodeling through plasmin generation. uPA usually binds to its receptor, uPAR, which is anchored to the plasma membrane through a glycosylphosphatidylinositol anchor. uPA\/uPAR binding increases proteolytic activity in the neighborhood of the cells containing uPAR and activates intracellular signaling pathways involved in extracellular matrix remodeling, cell migration and proliferation. The aim of this work was to study the expression of uPA, uPAR and plasminogen activator inhibitor-1 (PAI-1) in immature and in vitro matured bovine cumulus-oocyte complexes (COCs). uPA is only expressed in the cumulus cells of immature and in vitro matured COCs, while uPAR and PAI-1 are expressed in both the cumulus cells and the immature and in vitro matured oocytes. In addition, uPAR protein was localized by confocal microscopy in the plasma membrane of oocytes and cumulus cells of immature COCs. Results from this research led us to hypothesize that uPA\/uPAR interaction could cause, over the oocyte and cumulus cells surfaces, a local production of plasmin mediated by uPA; plasmin formation could also be regulated by PAI-1.","palabras_clave":"uPA|Ovocito|Oviducto|COCs"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":168,"idioma_id":4,"titulo":"Is otolith microchemistry (Sr:Ca and Ba:Ca ratios) useful to identify Mugil curema  populations in the Southeastern Caribbean Sea?","resumen":"The aim of the present study was to evaluate the potential use of otolithmicrochemistry (Sr:Ca y Ba:Ca ratios) to identify silver mullet, Mugil curema, populations in&nbsp;&nbsp;Southeastern Caribbean Sea. Fish samples were collected in 7 areas of Nueva Esparta State&nbsp;&nbsp;(Venezuela). The otolith Sr:Ca and Ba:Ca ratios and water Sr:Ca were determined (by ICP OES and EDTA volumetric method). Otoliths Sr:Ca and Ba:Ca ratios and Sr:Ca partition coefficient of mullets in Cubagua island (south of the State) were significantly different from ratios in La Guardia (north of the State). A discriminant analysis of otolith Sr:Ca and Ba:Ca ratios separated Cubagua Island from La Guardia values. These results suggest the existence&nbsp;&nbsp;of different mullet groups in the Southeastern Caribbean Sea. For this, the simultaneous use of&nbsp;&nbsp;Sr:Ca and Ba:Ca ratios could be a potential tool to identify populations in the study area.","palabras_clave":"mugilidae|fish resources|otolith|microchemistry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":170,"idioma_id":4,"titulo":"Natural diatomites: Efficient green catalyst for Fenton-like oxidation of Orange II","resumen":"The Fenton-like oxidation of the anionic azo-dye Orange II (100-500 mg\/L) was batchwise performed using commercial grade diatomites (3.5% Fe content) thermally treated. Solid samples were thoroughly characterized by several techniques. Peroxidation experiments were performed varying the diatomite calcination temperature (500, 700, 1000 C), reaction temperature (50,60, 70, 80 C), catalyst load (0.47, 0.94, 1.89 and 3.78 g), H2O2 concentration (11.0, 13.7, 20.6 mmol\/L) and dosing, pH (2-3.5) and initial dye concentration (0.28, 0.57, 1.43 mmol\/L). The influence of NaCl andoxalic acid on the catalytic performance and stability was also addressed. The best results were obtained with samples calcined at 700 C, with initial pH 3, at 70 C and using the stoichiometric amount of H2O2, since complete decoloration, TOC reduction close to 67% and negligible Fe leaching were achieved. The stability of the catalyst maintains after 20 h of usage, with a final Fe loss of 2.25%. An average of 0.88 mg\/L of iron leached after each run, which is below the discharge limit.","palabras_clave":"DIATOMITES|ORANGE II|FENTON-LIKE OXIDATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":171,"idioma_id":4,"titulo":"Catalytic behavior of Ru supported on Ce0.8Zr0.2O2 for hydrogen production","resumen":"Ru (2 wt.%) on Ce0.8Zr0.2O2catalysts were investigated to test their ethanol steam reforming (ESR) per-formance. The supports were obtained through two different synthesis methods: co-precipitation (PI)and mechanochemical reaction (MR). Characterization of the catalysts, before and after ESR, were per-formed using X-ray powder diffraction (XRPD), nitrogen physisorption, CO chemisorption, temperatureprogrammed reduction (TPR), high resolution transmission electron microscopy (HR-TEM), thermo-gravimetry, and X-ray photoelectron spectroscopy (XPS) measurements. The Ru (2 wt.%) PI catalystexhibited the highest activity and selectivity to hydrogen and no coke deposition was observed dur-ing catalytic operation, even when compared to Ni (8 wt.%) PI catalyst. A possible reaction pathway isproposed. The remarkably good catalytic performance of Ru (2 wt.%) PI is regarded as being due to acombination of factors: improved metal dispersion on Ce0.8Zr0.2O2, favorable metal-support interactionand water gas shift reaction promotion.","palabras_clave":"ETHANOL|HYDROGEN PRODUCTION|CATALYSIS|REFORMING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":172,"idioma_id":4,"titulo":"COMPARING ADJACENT CULTIVATED- AND 'VIRGIN' SOILS IN WIND EROSION AFFECTED ENVIRONMENTS CAN LEAD TO ERRORS IN MEASURING SOIL DEGRADATION","resumen":"Soil degradation has been frequently evaluated by comparing cultivated soils with paired reference pedons. Evaluated were some physical and chemical properties of cultivated and reference soils of a semiarid environment in a nine year period in order to evaluate possible changes in both management situations. Analyzed were seven degraded soils of variable textures, which are cultivated since more than 50 years, and seven paired neighbor pedons placed in the less disturbed Caldenal savanna-like ecosystem of the central semiarid region of Argentina. Results indicated that soil properties of both, cultivated and reference soils changed in this period. The driving factor of these changes was wind erosion, which produced a decrease in the proportion of the fine sized particles (silt and clay) in cultivated soils due to deflation processes, and an increase in reference soils due to the sedimentation of material transported from neighbor eroded soils. Medium textured soils (loamy sand) suffered the largest textural changes in agreement with more aggressive management practices that promoted wind erosion. The coarsest- (sandy) and the finest textured soils (sandy loam) did not show textural changes because they were managed with more conservative practices and were more resistant against erosion than medium textured soils. Under the moist conditions of the studied period contents of total carbon (OC), total carbohydrates (CHt) and nitrogen (N) increased by 50% in most reference soils. Cultivated soils presented 64% less OC, CHt and N than reference soils, but these differences were produced mainly by increases in reference soils rather than by decreases in cultivated soils. The C\/N and C\/CHt ratios decreased mainly in medium textured cultivated soils. The wind erodible fraction (EF, the < 0.84 mm sized aggregates) showed increases mainly in medium textured cultivated soils and decreases in all reference soils. This was associated with losses of the fine textural fractions and OC in cultivated soils and their increase in reference. Values for pH were higher only in some cultivated soils compared with reference pairs, but such differences were produced mainly by pH decreases in reference soils rather than by increases in the cultivated soils. The comparison of contrasting management systems considering that reference soils remain unchanged, may lead to overestimations of OC, CHt, N, EF and pH variations occurring in cultivated soils of 20 to 123%. Variations of C\/N and C\/CHt can be underestimated by 5 to 20%. We concluded that the simple comparison of cultivated and reference soils can lead to important errors in measuring soil degradation in semiarid environments. This may happen if changes eventually occurring in reference soils are not considered.","palabras_clave":"SOIL DEGRADATION|WIND EROSION|SEMIARID ENVIRONMENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":175,"idioma_id":4,"titulo":"Insulin-related signaling pathways elicited by light in photoreceptor nuclei from bovine retina","resumen":"Retina light stimulation triggers phototransduction events as well as different signaling mechanisms in outer segments (sensorial portion) of photoreceptor cells. We have recently reported a novel lightdependent activation of diacylglycerol kinase (DAGK) and protein kinase C (PKC) at the nuclear level ofphotoreceptor cells. The aim of the present study was to analyze whether ex-vivo light exposure of bovine retinas also modulates insulin-related signaling  pathways in nuclei from photoreceptor cells. To this end, a nuclear fraction enriched in small nuclei from photoreceptor cells (PNF) was obtained using a modified nuclear isolation protocol. In PNF obtained from bovine retinas exposed to light or darkness, the presence of insulin receptor (IR) and phosphorylated insulin receptor (pIR), the activation of Akt, p38 and extracellularsignal-regulated kinase (ERK1\/2) and the local action of insulin on lipid kinases were studied. Immunofluorescence (IF) and Western blot (WB) studies revealed the presence of IR in photoreceptor nuclei. In PNF a light-dependent increase in IR total contentwas observed. The presence of activated IR (pIR)was also observed in PNF by WB, being its content higher in PNF from light than in to darkness. Light exposure also produced a significant increase in the content of p-Akt (3 fold) and p-p38 (60%) without changes in total Akt and p38. In addition, an increase in the content of total ERK1\/2 (2 fold) was foundwithout changes in p-ERK\/total ERK ratio, indicating that light induces  Translocation of p-ERK to the nucleus.Polyphosphoinositide kinase and diacylglycerol kinase (DAGK) activities were measured in isolated nuclei from light-activated or darkness-adapted retinas through the formation of polyphosphoinositides (PPIs) and phosphatidic acid (PA) using nuclear lipid substrates and [gamma-32P]ATP as radioactive substrate. Alight-dependent increase in PPIs and PA formation was detected when isolated nuclei were exposed to 0.8 mM insulin plus 0.2 mM vanadate.WB studies revealed that retina's exposure to insulin under light condition increased nuclear IR content. In addition, PNF exposure to insulin increased ERK1\/2 phosphorylation with no changes in total ERK1\/2.Our results demonstrate the presence and the functional state of IR in the nucleus from photoreceptor cells. They also show that molecular signaling components linked to tyrosine kinase receptors and MAPK pathways, such as Akt and ERK1\/2, respectively, are present in photoreceptor nuclei and are regulated by insulin and light.","palabras_clave":"DIACYLGLYCEROL KINASE|INSULIN RECEPTOR|RETINA|BOVINE PHOTORECEPTOR NUCLEI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":176,"idioma_id":4,"titulo":"Tests in mice of a dengue vaccine candidate made of chimeric Junin virus-like particles and conserved dengue virus envelope sequences","resumen":"Two new vaccine candidates against dengue virus (DENV) infection were generated by fusing the coding sequences of the self-budding Z protein from Junin virus (Z-JUNV) to those of two cryptic peptides (Z\/DENV-P1 and Z\/DENV-P2) conserved on the envelope protein of all serotypes of DENV. The capacity of these chimeras to generate virus-like particles (VLPs) and to induce virus-neutralizing antibodies in mice was determined. First, recombinant proteins that displayed reactivity with a Z-JUNV-specific serum by immunofluorescence were detected in HEK-293 cells transfected with each of the two plasmids and VLP formation was also observed by transmission electron microscopy. Next, we determined the presence of antibodies against the envelope peptides of DENV in the sera of immunized C57BL\/6 mice. Results showed that those animals that received Z\/DENV-P2 DNA coding sequences followed by a boost with DENV-P2 synthetic peptides elicited significant specific antibody titers (&#8805;6.400). Finally, DENV plaque-reduction neutralization tests (PRNT) were performed. Although no significant protective effect was observed when using sera of Z\/DENV-P1-immunized animals, antibodies raised against vaccine candidate Z\/DENV-P2 (diluted 1:320) were able to reduce in over 50&nbsp;% the number of viral plaques generated by infectious DENV particles. This reduction was comparable to that of the 4G2 DENV-specific monoclonal cross-reactive (all serotypes) neutralizing antibody. We conclude that Z-JUNV-VLP is a valid carrier to induce antibody-mediated immune responses in mice and that Z\/DENV-P2 is not only immunogenic but also protective in vitro against infection of cells with DENV, deserving further studies. On the other side, DENV?s fusion peptide-derived chimera Z\/DENV-P1 did not display similar protective properties.","palabras_clave":"Dengue|Vaccine|VLPs|Z-protein-Junin-virus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":179,"idioma_id":5,"titulo":"La Nueva Economía del Siglo XXI: análisis de los impactos de la Informática en el Ambiente. Tendencias Actuales en Tecnologías Informáticas Verdes, un compromiso con la Sustentabilidad","resumen":"Los grandes avances tecnológicos producidos en las últimas décadas han generado profundos cambios sociales y organizativos en el ámbito de la información y las comunicaciones que inciden en nuestras vidas. La generalización en el uso de las computadoras, la proliferación de redes informáticas y el desarrollo de las nuevas tecnologías de la información y comunicación, denominadas TICS, cambiaron la manera de comunicarnos y transformaron la economía y la cultura para siempre, originando un sistema económico y social en el que la generación, procesamiento y distribución del conocimiento y la información son la principal fuente de laproductividad, poder y prosperidad. La informática y la industria en general no han ahorrado esfuerzos para desarrollarse rápidamente, pero en la mayoría de los casos, a costa del deterioro ambiental. Sin embargo, las TICSpueden ser un aliado en la lucha contra el cambio climático a través de procesos denominados Tecnologías Verdes, que se inscriben en el concepto de economía verde como contexto del desarrollo sustentable, conforme al documento final de Río + 20. El presente trabajo detallará la incidencia de la informática en los diferentes ámbitos y describirá, en términos generales, cada uno de los métodos y productos informático ecológicos","palabras_clave":"ECONOMIA|INFORMACION|AMBIENTE|TECNOLOGIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":180,"idioma_id":4,"titulo":"Seed burial depth and soil water content affect seedling emergence and growth of Ulmus pumilia var. sabulosa in the Horqin Sandy Land","resumen":"We investigated the effects of seed burial depth and soil water content on seedling emergence and growth, and the root\/shoot biomass ratio on Ulmus pumila var. sabulosa (sandy elm), an important native tree species distributed in the European-Asian steppe. Experimental seed burial depths in the soil were 0.5, 1.0, 1.5, 2.0 and 2.5 cm, and soil water contents were 4, 8, 12 and 16% of field capacity. All two-way ANOVAs (5 seed burial depths x 4 soil water contents) showed significant interactions (p<0.05) between the study treatments for all plant variables. Most of the times, seed burial depth and soil water content significantly affected all study plant variables. Seedling emergence was (1) at least 12.9% greatest at the lowest than higher seed burial depths, and (2) either similar (overall mean for all soil water contents at 1.5 and 2.0 cm soil depth=22%) or more than 14% smaller at lower than higher soil water contents at 0.5 and 1.0 cm soil depth. Seed burial depths greater than 1.5 cm reduced seedling growth at 4, 12 and 16% soil water contents. Also soil water contents lower than 12% most often increased root\/shoot biomass ratios in all study soil burial depths. The most suitable range of seed burial or soil water content was from 0.5 to 1.5 cm soil depth or 12 to 16%, respectively, for the processes of seedling emergence and growth. These findings indicate that seeds of sandy elm should be kept at rather shallow soil depths, and water be added up to 12 to 16% of soil capacity when conducting elm planting and management. Our findings could help to a more appropriate sandy elm cultivation, and understanding of the sparse elm woodland recruitment failures in arid and semi-arid regions.","palabras_clave":"DEPTH|WATER|ULMUS|CHINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":181,"idioma_id":4,"titulo":"Place Making and Heritage Urbanism in Latin-American","resumen":"Heritage Centres in Latin-America    In 1960 Europe started managing the concept of ?historic centre? to define areas consolidated in Medieval times and to differentiate them from urban extensions from the nineteenth and twentieth centuries. The concept was promptly adopted by Latin-America and translated across to places with relatively low urban dynamics which largely preserved their original characteristics however, in cities that suffered intense changes such as Sao Paolo, in Brazil, the notion of historic centre was not easily applicable as scattered architectural examples and urban forms were preserved.     In 1972, UNESCO included Historic Centres in the category of ?Group of Buildings? and in 1978 Quito, capital of Ecuador, was declared World Heritage Site. After these two major events, during the eighties, a large number of Latin-American city centres followed the trend: Olinda and Salvador, in Brazil; Lima, in Peru; La Habana, in Cuba; Zacatecas, in México and Cartagena, in Colombia, all with a focus on their architectural components without considering use, function or population. In time, this concept started to be reviewed and city centres began to be perceived as living areas organically transformed by their population. The main user and the local community began to be considered the priority and residents started to be placed at the heart of regeneration (Carrión, 2009).      This recent view encouraged the redefinition of the concept of Historic Urban Landscapes, a term that contemplates the natural and cultural heritage as well as the architectural assets of a city, articulating the conservation of the historic elements and the inclusion of the new additions, both in terms of the physical form and social intangible values.","palabras_clave":"HISTORIC CENTRES|HERITAGE|LATIN-AMERICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":182,"idioma_id":4,"titulo":"Thinking about Mobilities as Cultural Encounters: A Conversation with Guillermo Giucci","resumen":"For more than a decade a group of scholars has tried to reconstruct and analyze the history of mobilities in Latin America. Meetings such as the T2M annual conference and rich collaborative projects and publications have fostered a common approach to this work, a method built upon theoretical and methodological approaches as much as a common ?sensibility? toward mobilities. Without being fully aware of his position, Guillermo Giucci has been an invaluable member of this group. Although distance and other circumstances have prevented his direct participation in the meetings mentioned above, his work has nonetheless traversed the region, capturing the attention of fellow mobility scholars and becoming an essential reference for most ongoing work. Giucci?s in&#64258; uential position stems from his willingness to study subjects that few of his colleagues have grappled with and to break with the typical isolation and lack of comparative research found in Latin American mobility history. Trained in Uruguay and the United States and currently living in Brazil, where he lectures on comparative literature and Brazilian culture at the State University of Rio de Janeiro, Guillermo Giucci offers an interesting perspective on mobilities due to his transnational and multidisciplinary approach. His focus on the cultural encounters produced by the mobility of people, ideas, and objects has allowed his work to encompass numerous academic disciplines ranging from history, literature, and anthropology to sociology, psychology, and philosophy. His well-known book The Cultural Life of the Automobile: Roads to Modernity (University of Texas Press, 2012)?previously published in Portuguese (Civilização Brasileira, 2004) and Spanish (Universidad Nacional de Quilmes, 2007)?exempli&#64257; es This interview has been edited for clarity and length.28 ? Dhan Zunino Singh, Tomás Errázuriz, Rodrigo Booth, and Melina Pigliathe advantages of using cultural analysis to view a subject through its many iterations. In his work Giucci skillfully weaves webs of interpretations that broaden the problems he investigates rather than de&#64257; ning and trimming them. This approach can offer new views on even the most well-trodden subjects. While Giucci has not been explicitly involved in the so-called mobility turn, this interview aims to show that his work should be situated squarely within it. Giucci focuses on the relationships and encounters between people, objects, technologies, and ideas, going beyond the traditional divisions between subject and object, time and space, the ?real? and the imaginary. While it might sound strange, w e &#64257; nd similarities between Giucci?s methodology and the work of a psychoanalyst, who constantly records the issues, experiences, concerns, and dreams that a patient talks about. Like the psychoanalyst who is able to recognize the threads from events of a patient?s daily life that connect and explain personalities, Giucci has a special ability to detect relevant connections between a wide range of testimonies?linking the mundane events of daily life in ways not often seen in other research. Given this capability, Giucci?s long-standing admiration for Freud?s work should not come as a surprise. In a similar vein as the interviews featured in previous volumes of Mobility in History, we intend for this interview to pro&#64257; le this in&#64258; uential South American scholar. We hope to not only highlight his academic and biographical trajectory, but also to bring forward his interest, inquisitiveness, and questions and approaches to the study of mobility, culture, technologies, and Latin America, among other topics. We appreciate Guillermo?s kindness and willingness to respond to our questions during this conversation, a discussion that traipses from the personal to the intellectual. What follows allows us to know an imminent scholar better, but also pushes us to think more deeply about our own topics, theories, and methods?to go back to the ?kitchen? of research and see what new research practices, methodologies, and subjects we can cook up.","palabras_clave":"MOBILITY|AUTOMOBILITY|LATIN AMERICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":184,"idioma_id":5,"titulo":"Atribución de probabilidades, su vinculación con la significación y permutación de sucesos.","resumen":"Para analizar el efecto de la significación sobre la llamada Falacia de la Conjunción se administró  el Problema Clásico (PC) de Tversky y Kahneman (1982) y una modificación del mismo presentado en dos modalidades (PM1 y PM2). En cada uno se debía optar por dos opciones, según se le atribuyera mayor probabilidad a la ocurrencia de un suceso o la conjunción de ese suceso con otro y justificar su elección. Los Problemas presentaron el mismo relato introductorio pero distintas relaciones de las opciones con dicho relato. En el caso de PM1 y PM2, la diferencia entre ellos consistía en que en la opción de la conjunción los sucesos se presentaban permutados, situación que permitió estudiar su efecto en la asignación de probabilidades. Se realizó un análisis cuantitativo en función de la opción elegida y uno cualitativo en base a la categorizaron de las fundamentaciones. Participaron 147 jóvenes ingresantes a Universidades Nacionales, seleccionados por accesibilidad. Se encontró que para PM1 y PM2 las preferencias se volcaron mayoritariamente hacia la opción del suceso único, contrariamente a lo que sucedió en el PC. El análisis cualitativo permitió observar que los participantes se basaron ampliamente en criterios vinculados al contenido del problema.  .","palabras_clave":"PROBABILIDAD|SIGNIFICACIÓN|PERMUTACION|CONJUNCIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":186,"idioma_id":4,"titulo":"Synthetic aperture radar signal processing in parallel using GPGPU","resumen":"In this work an efficient parallel implementation of the Chirp Scaling Algorithm for Synthetic Aperture Radar processing is presented. The architecture selected for the implementation is the general purpose graphic processing unit, as it is well suited for scientific applications and real-time implementation of algorithms. The analysis of a first implementation led to several improvements which resulted in an important speed-up. Details of the issues found are explained, and the performance improvement of their correction explicitly shown.","palabras_clave":"Synthetic aperture radar|High performance computing|GP-GPU"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":188,"idioma_id":4,"titulo":"More Properties of Euclidean Distance Matrices and Elliptic Matrices","resumen":"Euclidean distance matrices (EDMs) have been studied for more that a century, although most of the results have appeared during the last fourty years or so. The main reason for the increasing interest in EDMs is because this convex cone serves as a model for important problems in applications. Among these problems are the molecular conformation problem in Chemistry and Molecular Biology (where these technique are known as Distance Geometry), the multidimensional scaling problem in Statistics and lately the sensor location problem among others. Elliptic matrices, which will be de&#64257;ne below, contain the convex cone of EDMs as proved in. More on the relation between EDMs is Elliptic matrices can be found in Tarazaga and Gallardo, and Fiedler.","palabras_clave":"EUCLIDEAN DISTANCE MATRICES|ELLIPTIC MATRICES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":189,"idioma_id":5,"titulo":"Mercado, fiscalidad y cuestión regional en la obra de José Carlos Chiaramonte","resumen":"(Indexado en Historical Abstract; Handbook of Latin American Studies, Scielo, Latindex, Caicyt) En mayo de 2015 se realizó en la UBA una Jornada de Homenaje a José Carlos Chiaramonte organizada por el Instituto Ravignani. En esa oprotunidad, se me invitó a participar como comentarista del trabajo de Roberto Schmit  en la mesa de 'Fiscalidad, moneda y cuestión regional'. Tales comentarios se encuentran en prensa y serán publicados, según certificación adjunta, en el nº 45 del Boletìn Ravignani en el segundo semestre de 2016.  Allí se sostiene que los aportes de José Carlos Chiaramonte a la historia económico-social tienen en muchos casos absoluta vigencia. Basta con recordar, para ello, su trascendental obra Nacionalismo y liberalismo económicos en Argentina,  publicada  a comienzos de la década de 1970 y reeditada más recientemente, donde no sólo se desarrollan temas vinculados a la fiscalidad y al mercado, sino también, y de manera muy explícita, se analizan las particulares características de las clases dominantes en la Argentina y su escasa vocación por convertirse en una burguesía industrial, como ciertos debates  y posiciones  producidas alrededor de las crisis de los años 1866 y 1873 parecían dejar entrever, así como también los efectos que los desequilibrios en los mercados internacionales ya tenían sobre un país con una clara tendencia agoexportadora, altamente dependiente de la demanda externa, en el marco de las características de la división internacional del trabajo por  entonces vigente.","palabras_clave":"MERCADO|FISCALIDAD|MONEDA|OBRA CHIARAMONTE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":192,"idioma_id":5,"titulo":"Fiscalidad y petróleo: un análisis tributarioambiental a partir de gravámenes concretos","resumen":"Este trabajo es un artículo de investigación científica que a partir de gravámenes concretos pretende demostrar el papel que los tributos pueden jugar ante los riesgos y daños ecológicos derivados del petróleo. Este análisis se construyó con base en una visión esencialmente dogmática del Derecho; de esta manera, la meta fue comprender primero y explicar después el significado de las normas positivas vigentes sobre los tributos ambientales. La principal conclusión afirma que si de prevenir y mitigar se trata, proponemos la regulación de tributos ambientales cuya presión fiscal no deje indiferente a los sujetos vinculados con las actividades petroleras. Si de obtener fondos para limpiar, recomponer o compensar se trata, proponemos la regulación de tributos, que más allá de la presión fiscal afecte a los sujetos vinculados con las actividades petroleras y destine la totalidad o mayoría de su recaudación a la limpieza, recomposición o compensación por la contaminación del petróleo.REVISTA INDEXADA:- ERIH PLUS- SCIELO- PUBLINDEX (Índice bibliográfico oficial de Colombia, Categoría B)- REDALYC- BASE DE DATOS LEXBASE- EBSCO- LATINDEX (En catálogo, con Doble referato - evaluadores externos)- DIALNET","palabras_clave":"PETRÓLEO|CONTAMINACIÓN|TRIBUTOS AMBIENTALES|DERECHO COMPARADO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":195,"idioma_id":4,"titulo":"Immune dysfunction in cirrhosis: Distinct cytokines phenotypes according to cirrhosis severity","resumen":"Background\/objectives: Cirrhosis associated immune dysfunction has been proposed to switch from a proinflammatoryphenotype in stable cirrhosis to an immunodeficient one in patients with decompensatedcirrhosis and acute-on-chronic liver failure. The aim of the present study was to compare serum cytokinelevels between healthy patients, stable cirrhosis, and decompensated cirrhotic patients with and withoutdevelopment of acute-on-chronic liver failure (ACLF); and to explore whether any of the measuredcytokines is associated with cirrhosis severity and prognosis in ACLF patients.Methods: Patients were enrolled from October 2013 to May 2014 in two hospitals located in BuenosAires. Cirrhotic patients with an acute decompensating event were enrolled accordingly to the developmentof ACLF defined by the CANONIC study group. There were two control groups: healthy subjects(n = 14) and stable cirrhotic patients (n = 14). Demographic, clinical and biochemical data were obtained.Seventeen cytokines were measured using Bio-Plex Pro Human Cytokine 17-plex Assay.Results: Of the 49 decompensated cirrhotic patients enrolled, 18 (36.7%) developed ACLF. Leukocyte count,MELD score at admission, Clif-SOFA at admission and day 7 were significantly higher in the ACLF group(p = 0.046, p < 0.001, p < 0.001, p < 0.001 respectively) as well as short-term mortality (p < 0.001)compared to stable and decompensated cirrhotic patients. In comparison with healthy controls, stablecirrhotic and decompensated cirrhotic patients showed increased levels of pro-inflammatory andanti-inflammatory cytokines: IL-6, IL-7, IL-8, IL-10, IL 12, and TNF-a. Decompensated cirrhotic patientswith the development of ACLF showed a significant decrease of IL-7, IL-10, IL-12, TNF-a, MCP-1 andIFN-c, but a sustained response of IL-6 and IL-8. When evaluating cirrhosis severity, IL-6 and IL-8correlated positively with MELD score, whereas only IL-6 correlated positively with Clif-SOFA score atday 7; IL-2 correlated negatively with Clif-SOFA at admission. In comparison with all scores, leukocytecount showed positive correlation and IFN-c negative correlation with disease severity. When evaluatingsurvival, only MELD and Clif-SOFA scores had a significant association with mortality.","palabras_clave":"cytokines"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":196,"idioma_id":5,"titulo":"Valores normales de los accidentes del Doppler tisular pulsado longitudinal en el perro registrado a nivel del anillo mitral.","resumen":"Con el objeto de determinar valores propios, en vista de la dispersión de los publicados, los autores estudiaron los accidentes del Doppler tisular longitudinal pulsado en perros beagles normales. Los valores medios obtenidos fueron los siguientes (expresados como media y desvío estándar): Velocidad pico (Vp) S: 0,928±0,232; Vp E´: 0,910±0,248; Vp A´: 0,762±0,246 Relación E´\/A´:1,273 ±0,384 y el tiempo A´E´: 0,271±0,041, de utilidad para el cálculo del índice de Tei. Al comparar los resultados obtenidos en la exploración de ambos sectores del anillo mitral (parietal y septal) se encontró que no se encontraron diferencias significativas en los valores correspondientes a la Vp de la onda S, de la relación E´\/A´ y el tiempo A´E´ mientras que las diferencias fueron significativas para las Vp de las ondas E´ y A´.","palabras_clave":"Doppler|Tisular|longitudinal|Beagles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":197,"idioma_id":4,"titulo":"Nutritional improvement and physicochemical evaluation of liver pâté formulations","resumen":"Pâté formulations composed of chicken liver, a by-product of poultry industry, have been produced by replacing pork back fat with sunflower oil and reducing fat content. The characterization of these products was performed, while the oxidative stability, microstructure, texture, colour, and hygienic quality were determined throughout refrigerated storage. The hardness of pâtés with sunflower oil was lower than the other ones. Different microstructures regarding protein matrix, fat globules and pores, were associated with fat type and content. The storage time, fat type and content influenced the colour parameters. In terms of the oxidative stability, no reduction in the product quality was found during the refrigerated storage. Pâtés with 28%w\/w of sunflower oil were the most suitable formulation to increase the nutritional value for this kind of meat products","palabras_clave":"Chicken liver pâté|physicochemical properties|refrigerated storage"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":201,"idioma_id":5,"titulo":"La pareja Educativa, una experiencia en el ámbito universitario","resumen":"El articulo aborda una experiencia realizada en la Universidad Nacional de Villa María en el marco de las catedras Teorias del Aprendizaje y en Didactica Genral y Currículum, sobre la enseñanza en pareja educativa; toma marcos teóricos de Loris Malaguzzi y de Enseñanza para ala comprensión de Harvard.","palabras_clave":"didactica|pareja educativa|nivel superior|experiencia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":203,"idioma_id":4,"titulo":"The efficacy of targeted health agents education to reduce the duration of untreated psychosis in a rural population","resumen":"The duration of untreated psychosis (DUP) is a key determinant in the severity of symptoms in patients with schizophrenia. DUP is a modifiable factor that if reduced can improve patient outcome and treatment response. We sought to decrease DUP in rural Argentina by instituting annual training of local health agents to better identify signs of mental illness and offer earlier intervention. DUP was estimated using Schedules of Clinical Assessment in Neuropsychiatry (SCAN). Ongoing training was correlated with a reduction in DUP. Reducing DUP through better screening can decrease the psychosocial burden of disease and improve the trajectory of psychosis.","palabras_clave":"Duration of untreated psychosis|Primary care intervention| Schedules of Clinical Assessment in Neuropsychiatry| Schizophrenia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":204,"idioma_id":5,"titulo":"Identificación de criterios de calidad para diseño de materiales multimedia","resumen":"Este trabajo se centra en la identificación de criterios e indicadores para la evaluación de la calidad de materiales didácticos hipermediales elaborados para carreras de Ingeniería. Para la realización del mismo se ha tenido en cuenta  como contribuyen estos materiales a la calidad académica. En particular porque se ha considerado la medición de los factores de diseño y la utilización de un sistema multimedia, en función de los requerimientos y hábitos de uso de los destinarios y del contenido específico del material.Los destinatarios de esta experiencia son alumnos del quinto año, asignatura Investigación Operativa II de la carrera de Ingeniería Industrial de la Universidad Nacional de Rosario. Para tal fin se hizo uso principalmente de una herramienta de calidad, como es el QFD (Quality Function Deployment) o ?Despliegue de función de la calidad?. La misma  puede definirse como un sistema estructurado que facilita el medio para identificar necesidades y expectativas de los clientes (voz del cliente) y traducirlas al lenguaje de la organización, esto es, a requerimientos de calidad internos, desplegándolas en la etapa de planificación con la participación de todas las funciones que intervienen en el diseño y desarrollo del producto o servicio. Esta herramienta se pregunta por la calidad verdadera, es decir, por 'QUÉ' necesitan y esperan los usuarios. También se interroga por 'CÓMO' conseguir satisfacer necesidades y expectativas. El presente trabajo también reporta la descripción de una prueba piloto y de la evaluación realizada en el propio contexto. Asimismo constituye un aporte a la calidad del  diseño, desarrollo e implementación de materiales multimediales, porque las  herramientas estadísticas y de calidad presentadas pueden ser utilizadas dentro de la metodología conocida como ?Planificar ? Hacer ? Comprobar ? Actuar? (PDCA). Estas actividades conforman un ciclo de realimentación necesaria para el logro de la mejora continua. El material multimedia deberá ser planificado definiendo en primer lugar los objetivos generales y particulares que persigue, establecer los usos que los alumnos y docentes harán de él. Una vez planificados y definidos los procesos deben ser ejecutados e implementados (hacer). En función de los requisitos y objetivos definidos en la planificación, se deberá realizar el seguimiento y medición del cumplimiento de cada uno de los procesos para realizar la comprobación de que el material cumple con los estándares definidos, mediante instrumentos como encuestas de satisfacción, mediciones de estándares, etc. La información surgida de la Comprobación servirá para actuar tomando acciones correctivas en los casos que sean necesarios y así mejorar continuamente los procesos.","palabras_clave":"CALIDAD E-LEARNING|DISEÑO MATERIALES MULTIMEDIAS|EDUCACIÓN INGENIERÍA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":205,"idioma_id":4,"titulo":"Taxonomy and paleoecology of a new gastropod fauna from dysoxic outer ramp facies of the Lower Cretaceous Agrio Formation, Neuquén Basin, west-central Argentina","resumen":"Four gastropod species are described from dysaerobic biofacies of the lower part of the Agua de la Mula Member of the Agrio Formation, Neuquén Basin: Metacerithium turriculatum (Forbes, 1845), Nerineopsis acutecarinatum (Behrendsen, 1891) and the new species Ampullina pichinka and Mesalia? kushea. They were active epifaunals and possibly deposit-feeders and\/or browsers, and epifaunal to semi-infaunal possibly suspension- or deposit-feeder in the case of M.? kushea, thriving in soft to firm substrates. These gastropods, together with two aporrhaid species, are largely the dominant component of a typically small-sized, low-diversity macrobenthic fauna that occurs in dark coloured, organic-rich shales. The facies associations in which this fauna is recorded are thought to represent a transition from lower to upper outer ramp marine settings, in the context of a second order TST and early stages of a HST. The bearing facies are also interpreted as recording a transition from lower dysoxic conditions in the lowest part of the Agua de la Mula Member, and then upper dysoxic conditions up to almost the top of the unit. Two gastropod biofacies were recognized corresponding to the two stages: biofacies A, dominated by P. neuquensis and N. acutecarinatum, more tolerant to dysoxic conditions, and biofacies B, dominated by M. turriculatum and M.? kushea, less tolerant to dysoxia.","palabras_clave":"GASTROPODA|HAUTERIVIAN|NEUQUÉN|ARGENTINA|DYSOXIA|BIOFACIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":207,"idioma_id":5,"titulo":"Aportes desde la bioarqueología al estudio de poblaciones urbanas de la colonia en Sudamérica (Mendoza, Argentina)","resumen":"En el presente trabajo se dan a conocer los resultados de los análisis de los restos óseos humanos recuperados mediante  intervenciones arqueológicas realizadas en el año 2009 por el Centro de Investigaciones Ruinas de San Francisco en el Templo San Francisco, ubicado en el Norte de Mendoza. El sector excavado corresponde a la pilastra R ubicada en la entrada del Templo del siglo XVIII, abarcando tanto el exterior como el interior del mismo. Se presentan los resultados de los estudios bioantropológicos y tafonómicos del conjunto óseo correspondiente a seis individuos articulados. También se define la cronología de cada individuo de acuerdo a su posición en el espacio y contexto de entierro. Estos estudios aportan a la caracterización de la salud y nutrición de las poblaciones históricas urbanas de la ciudad de Mendoza.","palabras_clave":"estrés fisiológico|patologías|poblaciones históricas|Mendoza (Argentina)"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":208,"idioma_id":4,"titulo":"Surface Structure and Chemistry of Alkanethiols on Au(100)-(1 × 1) Substrates","resumen":"The surface structure of self-assembled monolayers of hexanethiolate (HT) on the Au(100)-(1 × 1) surface has been studied by density functional theory (DFT) calculations and their results compared to scanning tunneling microscopy (STM) and X-ray photoelectron spectroscopy (XPS) data. We have found two novel surface structure models consisting of adsorbed thiolates on the Au(100)-(1 × 1) surface that fairly account for experimental STM and XPS observations. Surprisingly, these models exhibit better thermodynamic stability than those consisting of thiolate&#8722;Auad&#8722;thiolate moieties on a reconstructed Au(100)-(1 × 1) surface. Also theseproposed models are more stable than the thiolate&#8722;Auad&#8722;thiolate containing c(4 × 2) lattice on the reconstructed Au(111) suggesting a surface dependent chemistry for thiolates on Au. However, the possible existence of other models with similar or better stability than those proposed in this work and also the possible coexistence of different surface structures and chemistry on the substrate surface cannot be excluded.","palabras_clave":"Gold surfaces|thiols|XPS|STM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":212,"idioma_id":4,"titulo":"New genus of Psychodinae (Diptera, Psychodidae) from Argentina","resumen":"Adults (male and female) and pupae of Chuspilepia saltenia gen. nov., sp. nov. were collected in tree holes in the Yungas rainforest, near San Ramón de la Nueva Orán city, Salta province, Argentina. It was not possible to place this new species in any known genera using theavailable keys and published descriptions, thus a new genus is proposed for the Neotropical region of Argentina.","palabras_clave":"South America|new species|Chuspilepia|Rainforest"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":213,"idioma_id":4,"titulo":"Effective temperatures and scattering cross sections in water mixtures determined by Deep Inelastic Neutron Scattering","resumen":"The present work shows a series of results of Deep Inelastic Neutron Scattering (DINS) experiments on light and heavy water mixtures performed at the spectrometer VESUVIO (Rutherford Appleton Laboratory, UK) employing an analysis method based on the information provided by individual detectors in forward and backward scattering positions. We investigated the effective temperatures of the different atoms composing the samples, a magnitude of considerable interest for Nuclear Engineering. The peak intensities and their relation with the bound-atom cross sections is analyzed, showing a good agreement with tabulated values which supports the use of this technique as non-destructive mass spectrometry. Previous results in the determination of scattering cross sections by this technique (known in the literature) that were at variance with the present findings are commented.","palabras_clave":"Deep Inelastic Neutron Scattering|Light waterheavy water mixtures"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":214,"idioma_id":4,"titulo":"One-pot synthesis of ferrocenyl-pyrimidones using a recyclable molibdosilicic H4SiMo12O40 heteropolyacid","resumen":"A series of ferrocene-containing dihydropyrimidines (DHPs) were preparedby the one-pot Biginelli reaction of formylferrocene, 1,3-dicarbonyl componentand urea\/thiourea. The reaction was catalyzed by a commercial Kegginheteropolyacid (H4SiMo12O40) as a safe, clean and recyclable catalyst. Three different synthetic protocols were examined in order to improve the yields of thereaction and to elucidate its mechanism. Intermediates of the competitive Knoevenagel reaction were also isolated. The methodology is operationally simple and provides access to highly substituted dihydropyrimidines containing ferrocene in very good yields. The catalyst can be used and recycled without appreciable loss of the catalytic activity.","palabras_clave":"Ferrocene  Dihydropyrimidinones|Biginelli reaction|Recyclable Keggin heteropolyacid|One-pot reaction"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":215,"idioma_id":4,"titulo":"Selection of an actinobacteria mixed culture for chlordane remediation. Pesticide effects on microbial morphology and bioemulsifier production","resumen":"Chlordane bioremediation using actinobacteria mixed culture is an attractive clean-up technique. Their ability to produce bioemulsifiers could increase the bioavailability of this pesticide. In order to select a defined actinobacteria mixed culture for chlordane remediation, compatibility assays wereperformed among sixStreptomycesstrains.Thestrains did not showgrowth inhibition,and they were assayed for chlordane removal, either as pure or as mixed cultures.In pure cultures,all of the strains showed specific dechlorination activity (1.42?24.20 EU mg-1) and chlordane removal abilities(91.3?95.5%). The specific dechlorination activity was mainly improved with cultures of three or four microorganisms.Themixed culture consisting ofStreptomycessp.A2-A5-A13 was selected.Their ability to produce bioemulsifiers in the presence of glucose or chlordane was tested, but no significant differences were observed (p>0.05). However, the stability of the emulsions formed was linked to the carbon source used. Only in chlordane presence the emulsions retained 100% of their initial height. Finally, the selected consortium showed a high degree of sporulation in the pesticidepresence. This is thefirst study on the effects that chlordane exerts on microbe morphology and emulsifier production for a defined mixed culture ofStreptomyceswith ability to remediate the pesticide.","palabras_clave":"Mixed culture |Chlordane |Bioremediation |Bioemulsifier production"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":216,"idioma_id":4,"titulo":"Talaromyces systylus a new synnematous species from Argentinean semi-arid soil","resumen":"The discovery of an interesting new synnematous Talaromyces species from Argentinean semi-arid soil has enlarged the number of synnema-producing species. Talaromyces systylus sp. nov. is characterized by the production of indeterminate synnemata on Malt Extract Agar and coarsely rough-walled, globose conidia and conidial chains arranged in columns. The optimal growing temperature was 30°C. Talaromyces systylus was compared with other related species phylogenetically based on ITS, BenA and CaM markers.","palabras_clave":"ASCOMYCETES|EUROTIALES|PENICILLIUM SUBGENUS BIVERTICILLIUM|SYNNEMATA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":217,"idioma_id":4,"titulo":"Characterizing N+-perfect line graphs","resumen":"The aim of this paper is to study the Lovász-Schrijver PSD operator  applied to the edge relaxation of the stable set polytope of a graph. We are particularly interested in the problem of characterizing graphs for which  generates the stable set polytope in one step, called -perfect graphs. It is conjectured that the only -perfect graphs are those whose stable set polytope is described by inequalities with near-bipartite support. So far, this conjecture has been proved for near-perfect graphs, fs-perfect graphs, and webs. Here, we verify it for line graphs, by proving that in an -perfect line graph the only facet-defining subgraphs are cliques and odd holes.","palabras_clave":"stable set polytope|N+-perfect graphs| line graphs| PSD relaxation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":219,"idioma_id":4,"titulo":"Thermodynamically consistent elasto-plastic microplane formulation for fiber reinforced concrete","resumen":"In this work a thermodynamically consistent elasto-plastic microplane constitutive theory, aimed at simulating the failure behavior of Steel Fiber Reinforced Concrete (SFRC), is developed. The continuum (smeared crack) formulation, based on the microplane theory, assumes a parabolic maximum strength criterion in terms of normal and shear (micro-)stresses evaluated on each microplane to simulate the failure behavior of concrete. In the high confinement regime, a non-associated plastic flow rule is also defined in terms of microplane stresses. The well-known ?Mixture Theory? is considered to account for the presence of fibers in concrete matrix. The interaction between steel fibers and cracked concrete in the form of fiber-to-concrete bond-slip and dowel mechanisms is taken into account. The complete formulation is fully consistent with the thermodynamic laws. After describing the proposed constitutive theory, numerical analyses at constitutive level of SFRC failure behavior are presented and discussed. Thereby, the variations of the fracture energy, post-peak strength and cracking behavior with the fiber contents are evaluated and compared against experimental data. The attention also focuses on the evaluation of the sensitivity of SFRC failure predictions with the proposed constitutive model regarding fiber orientation on one hand, and the bond-slip bridging actions and dowel mechanism on the other hand.","palabras_clave":"Microplanes|Plasticity|Failure|MixtureTheory|Steel Fibers Reinforcement"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":220,"idioma_id":5,"titulo":"El dominio público como mecanismo de ordenación ambiental del territorio. Reflexiones a partir de un pronunciamiento de la Suprema Corte de Justicia de Mendoza","resumen":"El fenómeno de los barrios o complejos urbanos cerrados se ha desarrollado en ausencia de regulación y con importantes niveles de anomia, acudiendo a la utilización de diversas técnicas impropias. A partir de una sentencia judicial, se analiza críticamente el dominio público como instrumento de ordenación territorial, y la técnica de asignar usos privativos sobre el dominio público vial a través de permisos y concesiones como respuestas a las limitaciones de las políticas públicas en la materia.","palabras_clave":"ORDENAMIENTO TERRITORIAL|CONCESIONES|USOS COMUNES Y PRIVATICOS|DOMINIO PUBLICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":222,"idioma_id":4,"titulo":"Evaluating mating compatibility within fruit fly cryptic species complexes and the potential role of sex pheromones in pre-mating isolation","resumen":"The study of sexual behavior and the identification of the signals involved in mate recognition between con-specifics are key components that can shed some light, as part of an integrative taxonomic approach, in delimitating species within species complexes. In the Tephritidae family several species complexes have received particular attention as they include important agricultural pests such as the Ceratitis fasciventris (Bezzi), Ceratitis anonae (Graham) and Ceratitis rosa Karsch (FAR) complex, the Bactrocera dorsalis (Hendel) complex and the Anastrepha fraterculus (Wiedemann) complex. Here the value and usefulness of a methodology that uses walk-in field cages with host trees to assess, under semi-natural conditions, mating compatibility within these complexes is reviewed, and the same methodology to study the role of chemical communication in pre-mating isolation among Anastrepha fraterculus populations is used. Results showed that under the same experimental conditions it was possible to distinguish an entire range of different outcomes: from full mating compatibility among some populations to complete assortative mating among others. The effectiveness of the methodology in contributing to defining species limits was shown in two species complexes: Anastrepha fraterculus and Bactrocera dorsalis, and in the case of the latter the synonymization of several established species was published. We conclude that walk-in field cages constitute a powerful tool to measure mating compatibility, which is also useful to determine the role of chemical signals in species recognition. Overall, this experimental approach provides a good source of information about reproductive boundaries to delimit species. However, it needs to be applied as part of an integrative taxonomic approach that simultaneously assesses cytogenetic, molecular, physiological and morphological traits in order to reach more robust species delimitations.","palabras_clave":"species delimitation|field cages|Tephritidae|Anastrepha fraterculus|Bactrocera dorsalis|Ceratitis fasciventris|Ceratitis anonae|Ceratitis rosa"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":224,"idioma_id":4,"titulo":"Involvement of sulfates from cruzipain, a major antigen of Trypanosoma cruzi, in the interaction with immunomodulatory molecule Siglec-E.","resumen":"In orderto investigate the involvement of sulfated groups in the Trypanosoma cruzihost-parasite relationship, we studied the interaction between the majorcysteine proteinase of T. cruzi, cruzipain (Cz), a sulfate-containingsialylated molecule and the sialic acid-binding immunoglobulin like lectin-E(Siglec-E). To this aim, ELISA, indirect immunofluorescence assays and flowcytometry, using mouse Siglec-E-Fc fusion molecules and glycoproteins ofparasites, were performed. Competition assays verified that the lectins,Maackia amurensis II (Mal II) and Siglec-E-Fc, compete for the same bindingsites. Taking into account that Mal II binding remains unaltered by sulfation,we established this lectin as sialylation degree control. Proteins of anenriched microsomal fraction showed the highest binding to Siglec-E as comparedwith those from the other parasite subcellular fractions. ELISA assays and theaffinity purification of Cz by a Siglec-E column confirmed the interactionbetween both molecules. The significant decrease in binding of Siglec-E-Fc toCz and to its C-terminal domain (C-T) after desulfation of these moleculessuggests that sulfates contribute to the interaction between Siglec-E-Fc andthese glycoproteins. Competitive ELISA assays confirmed the involvement ofsulfated epitopes in the affinity between Siglec-E and Cz, probably modified bynatural protein environment. Interestingly, data from flow cytometry ofuntreated and chlorate-treated parasites suggested that sulfates are notprimary receptors, but enhance the binding of Siglec-E to trypomastigoticforms. Altogether, our findings support the notion that sulfate-containingsialylated glycoproteins interact with Siglec-E, an ortholog protein of humanSiglec-9, and might modulate the immune response of the host, favoringparasitemia and persistence of the parasite.","palabras_clave":"Trypanosoma cruzi|Cruzipain|sulfates |Siglec-E"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":227,"idioma_id":4,"titulo":"A high selectivity quaternized polysulfone membrane for alkaline direct methanol fuel cells","resumen":"Alkaline membranes based on quaternized poly(arylene ether sulfone) (QPAES) were characterized in relation to their water and methanol uptake, methanol permeability, electrical conductivity, and mechanical properties. The performance of QPAES as electrolyte in alkaline direct methanol fuel cells was  studied using a free-breathing single fuel cell at room temperature. Methanol uptake by QPAES membranes is lower than water, while their methanol permeability, determined in the temperature range from 30 C to 75 C, was much lower than for Nafion membranes. Young modulus of QPAES membranes decrease with the degree of alkalization of the membrane, although mechanical properties are still satisfactory for fuel cell applications for membrane alkalized with 2 M KOH, which additionally exhibit optimal hydroxide conductivity. Although the specific conductivity of QPAES membranes was lower than that reported for Nafion, its methanol selectivity (conductivity\/methanol permeability ratio), is much higher than that reported for Nafion 117, and a commercial amminated polysulfone. In view of these results, QPAES membranes are expected to exhibit promising performance as an electrolyte in alkaline direct methanol fuel cells.","palabras_clave":"Polysulfone|Membranes|Alkaline|Fuel cells|Methanol"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":230,"idioma_id":5,"titulo":"Identificación taxonómica mediante Citocromo b. Su aplicación a un caso arqueológico patagónico","resumen":"En este trabajo presentamos los primeros resultados de identificación taxonómica mediante el análisis del citocromo b de muestras óseas subactuales y arqueológicas (Holoceno tardío) procedentes de Patagonia. El bajo grado de determinación taxonómica de los restos óseos recuperados en el sitio Acevedo 1 (localidad de Río Pico, Provincia del Chubut, Argentina), alcanzada mediante el análisis zooarqueológico tradicional, y la necesidad del Laboratorio de Genética Forense del EAAF de identificar especies animales en contextos forenses, nos llevó a aunar esfuerzos y realizar un trabajo conjunto en torno al análisis del citocromo b en restos óseos no humanos. La identificación taxonómica de muestras subactuales lograda con este análisis confirma la efectividad de los protocolos seguidos en dicho laboratorio. Su aplicación a contextos arqueológicos, como lo prueban los resultados alcanzados en este trabajo, dependerá de la degradación de los materiales analizados. En el caso del sitio Acevedo 1 este análisis además permitió aportar la primera identificación arqueológica de huemul en el Centro oeste cordillerano del Chubut, aplicando una combinación del análisis del citocromo b con la morfología ósea comparativa. A pesar de los resultados positivos, el carácter destructivo del análisis y sus altos costos hacen que su aplicación deba ser evaluada adecuadamente en función de la problemática arqueológica bajo estudio.","palabras_clave":"Citocromo b|Patagonia|Taxonomía|Arqueología"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":231,"idioma_id":4,"titulo":"Double-stranded RNA synthesised in bacteria can be transferred to bee and varroa tissues","resumen":"In Argentina, the ectoparasite Varroa destructor and deformed wing virus (DWV) causes serious losses in localbeekeeping. New control methods have been proposed based on the RNA interference technique. Previous reportsshowed that bees fed with double-stranded RNA (dsRNA) synthesized in vitro reduce the transcription levels of thetarget genes in DWV and the varroa mite. An efficient and inexpensive alternative to produce dsRNA is the use ofbacteria capable of achieving a high level of in vivo synthesis. In this work, the possibility to use bacteria-mediated deliveryof dsRNA to bees and varroa tissues was evaluated. The obtained results indicated that bacterially expresseddsRNA can be transferred to the bee and from bee to the varroa mite.","palabras_clave":"double-stranded RNA|bacteria|honeybee|Varroa destructor"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":233,"idioma_id":4,"titulo":"50 years of Arabidopsis research: highlights and future directions.","resumen":"The year 2014 marked the 25th International Conference on Arabidopsis Research. In the 50 yr since the first International Conference on Arabidopsis Research, held in 1965 in Göttingen, Germany, > 54 000 papers that mention Arabidopsis thaliana in the title, abstract or keywords have been published. We present herein a citational network analysis of these papers, and touch on some of the important discoveries in plant biology that have been made in this powerful model system, and highlight how these discoveries have then had an impact in crop species. We also look to the future, highlighting some outstanding questions that can be readily addressed in Arabidopsis. Topics that are discussed include Arabidopsis reverse genetic resources, stock centers, databases and online tools, cell biology, development, hormones, plant immunity, signaling in response to abiotic stress, transporters, biosynthesis of cells walls and macromolecules such as starch and lipids, epigenetics and epigenomics, genome-wide association studies and natural variation, gene regulatory networks, modeling and systems biology, and synthetic biology.","palabras_clave":"arabidopsis|future|genetics|epigenomics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":234,"idioma_id":4,"titulo":"Physico-chemical and functional characterization of protein isolated from different quinoa varieties (Chenopodium quinoa Willd)","resumen":"The objective of this work was to investigate the nutritional and physico-chemical 27 characteristics as well as the functional properties of quinoa protein isolates (QPI) from 28 different varieties, and to analyze the possible use of such protein isolates in food products. 29 Proteins were isolated by iso-electric precipitation at pH 5 from quinoa flour, and the QPI had 30 a protein percentage of over 85%. The comparison of the flours and QPI electrophoretic 31 profiles indicated that the extraction method allowed isolating practically all proteins of each 32 variety. All the varieties analyzed had high lysine content, as compared to cereals, and the 33 essential amino acid content of Bolivian varieties was higher than varieties from Peru. The pH 34 value affected the solubility and foaming capacity (FC) and the magnitude of effects 35 depended on the variety. Cluster analyses showed a strong influence of variety source and 36 amino acid composition on protein physico-chemical and functional properties; samples from 37 Bolivia (Cluster 2) were characterized as having the highest thermal stability, oil binding 38 capacity (OBC) and water binding capacity (WBC) at acid pH; samples from Peru (Cluster 1) 39 had the highest WBC at basic pH and FC at pH 5. QPI presented a potential as an alternative 40 vegetable protein for food application, in particular for vegetarian and vegan diets.","palabras_clave":"QUINOA|PROTEIN ISOLATES|ELECTROPHORESIS|ESSENTIAL AMNOACIDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":235,"idioma_id":4,"titulo":"Non-parametric upscaling of stochastic simulation models using transition matrices","resumen":"1. The problem of scaling up from tractable, small-scale observations and experiments to prediction of largescalepatterns is at the core of ecological theory and application, and one of the central problems in ecology.2. We present and test a general nonparametric framework to upscale spatially explicit and stochastic simulationmodels. The idea is to design a state space, defined by the important state variables of the small-scale model, andto divide it into a finite number of discrete states. Transition probabilities are then tallied by monitoring extensivesimulation runs of the small-scale model, covering the entire range of initial conditions, states and external driversthat may occur for the desired application. We exemplify our approach by upscaling an individual-basedmodel that simulates the spatiotemporal dynamics of Festuca pallescens steppes under sheep grazing in WesternPatagonia, Argentina, with a spatial resolution of 03 m 9 03 m and a 015-ha extent. The upscaled model simulatesa 2500-ha paddock with 015-ha resolution and is enriched with additional rules that describe heterogeneityin the local stocking rate at the paddock scale.3. We obtained 24 transition matrices that governed the upscaled model for different combinations of stockingrates and annual precipitation. The upscaled model produced excellent predictions for the long-term dynamics,but as expected, it did not fully capture the interannual dynamics of the original model. Rules for heterogeneityin the local stocking rate allowed for emergence of realistic vegetation patterns as commonly observed for waterpoints in arid rangelands.4. Our general nonparametric upscaling approach can be applied to a wide range of stochastic simulation modelsin which the dynamics can be approximated by a set of states, transitions and external drivers. Because estimationof the transition probabilities can be done parallel, our approach can be applied to a wide range of models ofintermediate complexity. Our approach closes a gap in our ability to scale up from small scales, where the biologicalknowledge is available, to larger scales that are relevant for management.","palabras_clave":"agent-based models|complex systems|graph theory|Markov chains"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":238,"idioma_id":4,"titulo":"Ability to recover overrides the negative effects of flooding on growth of tropical grasses Chloris gayana and Panicum coloratum","resumen":"This study assessed the flooding tolerance of tropical grasses Chloris gayana and Panicum coloratum, at different moments of the year: (i) late winter flooding for 50 days (WF), (ii) early spring flooding (SF) for 20 days, and (iii) long-term flooding covering both periods (WF+SF, 70 days). A growth-period under well watered conditions was allowed after each flooding event to assess plant species recovery. Plants were harvested after each flooding event, and at the end of the recovery period. P. coloratum had higher tolerance to WF than C. gayana. WF did not affect biomass in P. coloratum while it reduced biomass of flooded plants by 38% in C. gayana. SF did not differentiate species? tolerance as both registered similar and moderate reduction in their growth (20 to 30%). Under long-term flooding (WF+SF), C. gayana showed additional reduction in its growth to that observed when subjected separately to either WF or SF, while P. coloratum did not. Remarkably, both species displayed outstandingly fast recovery from flooding when temperatures rose during early summer, attaining equivalent biomass to that of non-flooded plants in only one month after water subsided. So, although P. coloratum appears as slightly more tolerant during flooding than C. gayana, both species look promising to be introduced in temperate lowland grasslands.","palabras_clave":"seasonal flooding|Chloris gayana|Panicum coloratum|plant recovery"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":240,"idioma_id":4,"titulo":"Alternatives to prevent the failure of RC members under close-in blast loadings","resumen":"In this paper, an experimental study of the dynamic response of reinforced concrete (RC) members protected in different ways is presented. Two alternatives for the protection of RC members are designed and studied; classical steel jacketing and a new reinforced polyurethane sacrificial layer. The mitigation of shock and absorption of energy from the blast is studied with experimental methods. For comparison purposes, a RC member without protection is also tested and studied. As expected, the steel jacketing provided excellent protection reducing the maximum final deflection as well as reducing damage to the member. On the other hand, the proposed reinforced polyurethane protection performed reasonably well. The obtained results are useful for exploring new alternatives for the protection of RC columns as well as for the calibration of numerical codes.","palabras_clave":"NEAR FIELD EXPLOSIONS|STEEL JACKETING|REINFORCED POLYURETHANE|EXPERIMENTAL TESTS|MATERIAL FAILURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":243,"idioma_id":4,"titulo":"Synthesis of water-soluble oligomers from imidazole, ethyleneglycol diglycidyl ether and methacrylic acid. An insight into the chemical structure, aggregation behavior and formation of hollow spheres","resumen":"The synthesis of non-soluble polyampholytes was modified to obtain water-soluble oligomers, by a sequential reaction at 60&#8201;°C of imidazole (IM), ethyleneglycol diglycidyl ether (EGDE) and methacrylic acid (MAA). The hydrogel Poly(EGDE-IM) with disubstituted imidazole (IM+) residues, enhanced its solubility in water by functionalization with Poly(MAA). NMR and mass spectrometry evidenced ester groups, Poly(MAA) chains, Poly(EGDE), and IM+ links. Capillary electrophoresis evidenced populations with positive net charge at pH lower than 9, due to IM+ and protonatable residues (IMH+). Water-soluble aggregates of oligomers were detected by size exclusion chromatography. The product aggregated with cations such as Fe(II) adsorbing anionic compounds, and formed hollow spheres when citric acid was present.","palabras_clave":"OLIGOMEROS|CAPSULAS|NMR EN SÓLIDOS|MACROMOLÉCULAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":244,"idioma_id":4,"titulo":"AtCBF1 Overexpression Confers Tolerance to High Light Conditions at Warm Temperatures in Potato Plants","resumen":"We characterized transcriptional responses of potato plants to multiple abiotic stresses and used this information to identify potential mechanisms through which over-expression of the stress related transcription factor CBF1 from Arabidopsis thaliana (AtCBF1) confers multiple stress tolerance. Most transcriptional changes were specific to each condition, but genes involved in phenyl-propanoid biosynthesis were affected by all abiotic stresses evaluated. Interestingly, over-expression of AtCBF1 in potato plants not only conferred tolerance to low temperatures, as previously reported, but also to high-light conditions at 22&nbsp;°C, suggesting that it confers multiple stress tolerance by enhancing the ability of plants to cope with an excess of radiant energy. Finally, we found that transcriptional changes triggered by abiotic stress were much larger than those resulting from AtCBF1 over-expression in potato, revealing that overexpression of an heterologous transcription factor causes minor alterations in the plant transcriptome in comparison to transcriptional changes triggered by abiotic stresses.","palabras_clave":"CBF1 |Transgenic plants|Drought|Temperature"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":245,"idioma_id":4,"titulo":"Entropic measures of joint uncertainty: Effects of lack of majorization","resumen":"We compute Rényi entropies for the statistics of a noisy simultaneous observation of two complementary observables in two-dimensional quantum systems. The relative amount of uncertainty between two states depends on the uncertainty measure used. These results are not reproduced by a more standard duality relation. We show that these behaviors are consistent with the lack of majorization relation between the corresponding statistics.","palabras_clave":"QUANTUM UNCERTAINTY|RENYI ENTROPIES|MAJORIZATION|COMPLEMENTARITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":247,"idioma_id":4,"titulo":"Visible-light photopolymerization of DGEBA promoted by silsesquioxanes functionalized with cycloaliphatic epoxy groups","resumen":"Diglycidyl ether of bisphenol A (DGEBA) is among the most popular and widely used epoxy monomers. This monomer is commonly used in thermal network polymerizations with amines, phenols, isocyanatesor mercaptans as curing agents. However, the photoinitiated polymerization of DGEBA is very sluggishand hence finds little use in high-speed photocuring applications. In this contribution, we demonstratedthat this monomer can undergo very fast visible-light photopolymerization when combined with asilsesquioxane (SSO) functionalized with reactive epoxycyclohexane groups. The SSO was synthesized viaalkoxysilane hydrolysis\/condensation chemistry, using DGEBA as a solvent. We found that the photopolymerization of DGEBA is markedly accelerated as the amount of SSO in the mixture is increased. The promoter effect on the reactivity of DGEBA was ascribed to a combination of both thermal and copolymerization effects. Using dynamic mechanical analysis, we demonstrated that the resulting hybridmaterials present a single-phase network structure, where the SSO species function as highly multifunctionalepoxy reactants.","palabras_clave":"PHOTOINITIATED CATIONIC POLYMERIZATION|EPOXY NETWORKS|SILSESQUIOXANES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":249,"idioma_id":4,"titulo":"DIVERSITY OF PSEUDO-TOOTHED BIRDS (PELAGORNITHIDAE) FROM THE EOCENE OF ANTARCTICA","resumen":"The Antarctic pelagornithid record is restricted to few isolated remains from the Eocene of Seymour Island in the Antarctic Peninsula. Here we report the oldest Antarctic pseudo-toothed bird. It is represented by an incomplete humerus lacking its proximal end, which comes from the lower Eocene levels of the La Meseta Formation (Seymour Island). This new specimen facilitates a review of all known pelagornithids from this continent. Antarctic pelagornithids were classified into two morphotypes which exhibit a mix of putative plesiomorphic and derived characters. Considering the worldwide pelagornithid record and according to estimated wingspans, four approximate size-types were identified. The oldest Antarctic specimens (two fragmentary humeri, middle Ypresian) were assigned to morphotype 1 and correspond to the large sized-type. The younger materials (Bartonian\/?Priabonian) here assigned to morphotype 2 (some cranial remains, fragmentary tarsometatarsus and humerus) correspond to the giant size-type and represent one of the largest known pseudo-toothed birds. Even though species level phylogenetic affinities of Pelagornithidae remain poorly resolved, three key evolutionary events can be recognized: 1) the disappearance of Dasornis in the Early Eocene and the appearance of more advanced forms with a trend to the specialization of large soaring capacity; 2) the origin of Pelagornis sensu lato species in the early Oligocene; 3) the appearance and dominance of a highly specialized terminal group at Mio\/Pliocene time span.","palabras_clave":"Antártida|Marambio|Eoceno|Pelagornithiidae"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":251,"idioma_id":4,"titulo":"A NEW PEIROSAURID (CROCODYLIFORMES,  MESOEUCROCODYLIA)  FROM THE UPPER CRETACEOUS OF PATAGONIA, ARGENTINA.","resumen":"Peirosaurids constitute a group of Gondwanan Cretaceous continental&nbsp; crocodyliforms. Two species are known for the Neuquén Group, Argentina: Lomasuchus&nbsp; palpebrosus Gasparini et al. (Portezuelo Formation, Late Turonian?Early Coniacian) and&nbsp; Gasparinisuchus peirosauroides Martinelli et al. (Bajo de la Carpa and Anacleto&nbsp; Formations, Santonian and Early Campanian, respectively). Here, we describe the first&nbsp; peirosaurid identified for the Cerro Lisandro Formation, Bayomesasuchus hernandezi gen.&nbsp; et sp. nov. The material corresponds to a fragmentary skull and mandible. Although&nbsp; fragmentary, this is the most complete crocodyliform specimen recorded for the Cerro&nbsp; Lisandro Formation. The phylogenetic analysis indicates that corresponds to a new peirosaurid closely related with the African forms.","palabras_clave":"BAYOMESASUCHUS|PEIROSAURIDAE|CERRO LISANDRO FORMATION|CRETACEOUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":252,"idioma_id":4,"titulo":"Liquid-liquid extraction of protease from coldadapted yeast Rhodotorula mucilaginosa L7 using biocompatible and biodegradable aqueous twophase systems","resumen":"This work aimed to optimize the extraction of an extracellular protease produced by the coldadapted yeast Rhodotorula mucilaginosa L7 using aqueous two-phase systems (ATPS) comprising polyethylene glycol (PEG) and sodium citrate or sodium tartrate. First, the biocompatibility of the phase forming agents was assessed. The results obtained with PEG-2000, PEG-4000, and PEG-6000 demonstrated that even at large PEG concentrations (32 wt%) the protease maintains its activity after 3 h of reaction, whereas an increase in salt concentration provokes a gradual decrease in protease stability. Subsequently, the partitioning of the protease in both types of ATPS was assessed,evaluating the effect of temperature, molecular weight, and concentration of PEG on protease purification, using two 23-full factorial designs. The best partitioning conditions were obtained in PEG-6000\/sodium tartrate-based ATPS, at 30ºC (with a yield of 81.09 ± 0.66% and a purification factor of 2.51 ± 0.03). Thus, considering the biodegradable characteristics of the system, the PEG\/sodiumtartrate ATPS is a viable and economic low-resolution step in protease purification, with a strong potential for future industrial application.","palabras_clave":"PROTEASE|COLD-ADAPTED MICROORGANISMS|LIQUID-LIQUID EXTRACTION|AQUEOUS TWO PHASE SYSTEMS|PURIFICATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":253,"idioma_id":4,"titulo":"New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: a Pilot Short-Term Follow-Up Study with Adult Patients","resumen":"There is a clinical need to test new schemes of benznidazole administration that are expected to be at least as effective as the current therapeutic scheme but safer. This study assessed a new scheme of benznidazole administration in chronic Chagas disease patients. A pilot study with intermittent doses of benznidazole at 5 mg\/kg\/day in two daily doses every 5 days for a total of 60 days was designed. The main criterion of response was the comparison of quantitative PCR (qPCR) findings prior to and 1 week after the end of treatment. The safety profile was assessed by the rate of suspensions and severity of adverse effects. Twenty patients were analyzed for safety, while qPCR was tested for 17 of them. The average age was 43 ± 7.9 years; 55% were female. Sixty-five percent of treated subjects showed detectable qPCR results prior to treatment of 1.45 (0.63 to 2.81) and 2.1 (1.18 to 2.78) parasitic equivalents per milliliter of blood (par.eq\/ml) for kinetoplastic DNA (kDNA) qPCR and nuclear repetitive sequence satellite DNA (SatDNA) qPCR, respectively. One patient showed detectable PCR at the end of treatment (1\/17), corresponding to 6% treatment failure, compared with 11\/17 (65%) patients pretreatment (P = 0.01). Adverse effects were present in 10\/20 (50%) patients, but in only one case was treatment suspended. Eight patients showed mild adverse effects, whereas moderate reactions with increased liver enzymes were observed in two patients. The main accomplishment of this pilot study is the promising low rate of treatment suspension. Intermittent administration of benznidazole emerges a new potential therapeutic scheme, the efficacy of which should be confirmed by long-term assessment posttreatment.","palabras_clave":"Chagas|Trypanosoma cruzi|Benznidazole|Treatment"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":254,"idioma_id":4,"titulo":"Know thy enemy: interspecific differences of pine consumption among leafcutter ants in a plantation","resumen":"The damage to plantations by pests is often determined by perceptions rather than objective data, resulting in excessive use of pesticides. Leafcutter ants are considered important pests to plantations in America. We evaluated the difference in Pinus taeda biomass consumption by four Acromyrmex leafcutter ant species which co-inhabit plantations of this pine species. These ants exhibit morphological and behavioral differences, i.e., Ac. heyeri has mandibles adapted to cut monocots, while the other species cut dicots, which may result in differences in their consumption of pine. We collected the plant biomass that ants carried into their nests and recorded the foraging activity in different seasons throughout a year. The P. taeda biomass carried into leafcutter nests was less than 20&nbsp;% compared to total plant biomass. Colonies with greater foraging activity carried a greater amount of total biomass, but they did not carry more pine biomass. The leafcutter ant species studied differed in their use of pine biomass, but not of total biomass. Acromyrmex ambiguus and Ac. crassispinus were the species carrying the greatest amount of pine biomass and with more colonies using pine, whereas very little amounts of pine were carried by Ac. heyeri and by very few colonies. Thus, leafcutter ant species do not cause the same damage to pine plantations. Our results also highlight the importance of pest management strategies based on a thorough knowledge of the biology of the species, including those characteristics which can predict the use that each species will make of the plantation.","palabras_clave":"Acromyrmex|Pinus taeda|forestation|species traits|pest species"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":255,"idioma_id":5,"titulo":"Un individuo-sujeto. El yo como una unidad compleja","resumen":"Los asuntos que interpelan al sujeto refieren claramente al yo individual pero sobre todo la pregunta por el sujeto supone necesariamente un yo que está-siendo en la vida y en relación. La pregunta por el sujeto nos envuelve permanentemente en una serie de problemáticas que parecen irresolubles pero el sujeto en la propia indagación de sí mismo puede exponerlas y comunicarlas. Siguiendo a Edgar Morin mostraremos al sujeto con-formado en un tejido que es a la vez uno y plural.","palabras_clave":"individualidad|dependencia|autonomía|organización"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":257,"idioma_id":4,"titulo":"Stability of oil-in-water emulsions with sunflower (Helianthus annuus L.) and chia (Salvia hispanica L.) by-products","resumen":"Emulsifiersand stabilizers play an important role in emulsion stability. Opticalcharacterization and droplet size distribution of oil-in-water emulsionsformulated with different types and concentrations of modified sunflowerlecithin (phosphatidylcholine (PC) enriched lecithin and deoiled sunflowerlecithin), with or without chia mucilage (0.75% wt\/wt), have been evaluated asa function of storage time at 4±1 ºC. Emulsions with PC-enriched lecithin(without chia mucilage) exhibited the highest stability at the differentconcentrations because of the high PC\/phosphatidylethanolamine (PE) ratio in comparisonto Control lecithin. The addition of 0.75% wt\/wtmucilage contributed to obtain stable emulsions for all type and concentrationsof emulsifiers studied, mainly with PC-enriched lecithin due to the reductionof the mobility of oil particles by the formation of a tridimensional network.","palabras_clave":"MODIFIED SUNFLOWER LECITHIN|CHIA MUCILAGE|OIL-IN-WATER EMULSIONS|STORAGE CONDITIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":258,"idioma_id":5,"titulo":"DISTRIBUCIÓN DE LAS PARASITOSIS INTESTINALES EN POBLACIONES INFANTO-JUVENILES: UN ESTUDIO  TRANSVERSAL EN DIFERENTES PROVINCIAS ARGENTINAS","resumen":"Objetivo. Analizar la distribución de las enteroparasitosis en poblaciones infanto-juveniles de diferentes localidades argentinas como representantes de un mosaico de ambientes contrastantes. Métodos. Se procesaron muestras fecales y de escobillado anal seriadas por técnicas de concentración. Los resultados se analizaron por sexo, intervalos etarios y provincia de residencia. El análisis estadístico se realizó mediante Epi Info 7.   Resultados. Misiones presentó la mayor prevalencia de niños parasitados y Chubut la menor (82% vs. 38,4%; p&#706;0,01). La riqueza específica fue mayor en Misiones y Buenos Aires (12) y menor en Chubut y La Pampa (6). Los varones estuvieron más parasitados que las mujeres en Buenos Aires. Los niños &#8804; 5 años de Buenos Aires y los &#8805; 6 años de Mendoza y Misiones resultaron más parasitados (p<0,05). El monoparasitismo fue más frecuente en Chubut (65,5%) y las parasitosis múltiples, en Formosa (69,2%). Las especies más prevalentes en la mayoría de las provincias fueron Blastocystis sp. y E. vermicularis. En cuanto a las prevalencias de geohelmintos, Misiones presentó el máximo valor (23,3%) y Mendoza, el más bajo (0,6%). No se hallaron geohelmintos en Chubut, La Pampa y Salta. Se hallaron asociaciones entre pares de especies parásitas (p<0,05). Buenos Aires, Formosa, Mendoza y Misiones presentaron una composición de especies similar y valores superiores al 90%. Conclusiones. Las diferencias observadas en la prevalencia de cada especie parásita, muestran un mosaico de variabilidad que podría responder a las condiciones tanto climáticas como socio-ambientales propias de cada región y extendidas de norte-sur y este-oeste de la Argentina.","palabras_clave":"parasitosis intestinales|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":259,"idioma_id":5,"titulo":"Pensamientos políticos de lo singular","resumen":"Las reflexiones filosóficas en torno de la singularidad y la ejemplaridad son centrales para comprender gran parte de las producciones que tienen lugar hoy en las llamadas ciencias sociales. Ni cuantitativo ni cualitativo, lejos de los objetos y de los sujetos, del dualismo particular\/universal, la filosofía política contemporánea ofrece un conjunto de consideraciones centrales para hacer estallar el campo de reflexión, encorsetado por la lógica del cálculo, que ha predominado en las ciencias sociales (y que predomina aún hoy, siguiendo esos 'pellejos vacíos', 'moles ónticas', especialmente en los denominados centros académicos). En pocas palabras, lo que las ciencias humanas y sociales quieren extirpar a toda costa es el elemento incalculable, asociado a la práctica de lectura y escritura (política, histórica y situada) en tanto que intervención singular en un horizonte posfundacional. Pero más allá de lo que las instituciones académicas proponen e imponen respecto de la forma de hacer 'ciencia', he aquí que el ensayo, un texto no acabado y confrontado a la falta, a la limitación, al ejemplo y a lo singular de una escritura, no deja de atravesar anárquicamente el quehacer académico. Sin embargo, cuando irrumpe el vacío de una biografía ya no pueden mantenerse las viejas oposiciones tranquilizadoras ni las fronteras entre las disciplinas, ya que lo que se impone es la política como praxis viva atraviesa que todos los órdenes (el institucional, el filosófico, el histórico, el científico) y obliga a repensar, a partir de de ciertas figuras o constelaciones singulares, 'ejemplares', el campo de trabajo como campo de batalla y de fuga del acontecimiento.","palabras_clave":"SINGULARIDAD |EJEMPLARIEDAD |DERRIDA|BENJAMIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":260,"idioma_id":5,"titulo":"Cuando la clave es integrar: Introducción al desarrollo de grupos de comportamiento de dormición de malezas en cultivos agrícolas","resumen":"La intensificación agrícola ha generado la aparición de malezas de difícil control, tanto por cambios en su abundancia, como por el surgimiento de genotipos tolerantes o resistentes a herbicidas. Por ello es importante desarrollar aproximaciones analíticas basadas en la biología de las malezas que permitan predecir cambios flo-rísticos ante diferentes escenarios ambientales. Aunque existen descripciones sobre el funcionamiento de ciertas especies en particular, es escaso el desarrollo de aproximaciones que aborden la predicción del enmalezamiento de manera mecanística. Este trabajo plantea un marco teórico novedoso para el estudio del proceso de enmalezamiento a través del estudio de los efectos de distintos filtros ambientales sobre el riesgo de salida de dormición de propágulos en campos agrícolas, aspecto clave para entender el riesgo de establecimiento de malezas en estos sitios. Para ello se describe la clasificación de especies de malezas en grupos de comportamiento de dormición (GCD), y se describe de manera cualitativa la influencia de distintos filtros ambientales sobre la determinación de ocurrencia de los GCD descriptos. En total se identificaron cuatro GCD de especies anuales y tres de especies perennes, a través de una revisión de 150 trabajos de la literatura. La aproximación teórica descripta en este trabajo ayuda a sistematizar de manera más eficiente el abordaje del problema del enmalezamiento, reduciendo su complejidad basándose en el uso de estrategias funcionales en lugar de las identidades de las especies.Agricultural intensification has led to the emergence of weeds difficult to control, owing to changes in abundance, for the development of tolerance or resistance to herbicides. It is therefore important to develop analytical approaches based on the biology of weeds, to predict floristic changes under different environmental scenarios. Although there are descriptions of the operation of particular species, there is littledevelopment of approaches that address weed growth forecast of mechanistic way. This paper proposes a novel theoretical framework for the study of the process of weeds growth through the effects of differentenvironmental filters about the risk of dormant propagules in agricultural fields, key to understanding the risk of establishment of weeds in these sites. Here, the classification of weed species in dormancy behavior groups (GCD) is described, and describes qualitatively the influence of different environmental filters on the determination of occurrence of GCD. A total of four GCD of annuals and three perennials were identified in a review of 150 works of literature. The theoretical approach described in this paper helps to systematizemore efficiently the problem of weeds growth, reducing complexity by relying on the use of functional strategies rather than the identities of the species.","palabras_clave":"malezas|dormición|enmalezamiento|modelos funcionales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":262,"idioma_id":4,"titulo":"The E3 ubiquitin-ligase SEVEN IN ABSENTIA like 7 mono-ubiquitinates glyceraldehyde-3-phosphate dehydrogenase 1 isoform in vitro and is required for its nuclear localization in Arabidopsis thaliana.","resumen":"The E3 ubiquitin-protein ligases are associated to various processes such as cell cycle control and diverse developmental pathways. Arabidopsis thaliana SEVEN IN ABSENTIA like 7, which has ubiquitin ligase activity, is located in the nucleus and cytosol and is expressed at several stages in almost all plant tissues suggesting an important role in plant functions. However, the mechanism underlying the regulation of this protein is unknown. Since we found that the SEVEN IN ABSENTIA like 7 gene expression is altered in plants with impaired mitochondria, and in plants deficient in the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase 1, we decided to study the possible interactions between both proteins as potential partners in plant signaling functions. We found that SEVEN IN ABSENTIA like 7 is able to interact in vitro with glyceraldehyde-3-phosphate dehydrogenase and that the Lys231 residue of the last is essential for this function. Following the interaction, a concomitant increase in the glyceraldehyde-3-phosphate dehydrogenase catalytic activity was observed. However, when SEVEN IN ABSENTIA like 7 was supplemented with E1 and E2 proteins to form a complete E1?E2?E3 modifier complex, we observed the mono-ubiquitination of glyceraldehyde-3-phosphate dehydrogenase 1 at the Lys76 residue and a dramatic decrease of its catalytic activity. Moreover, we found that localization of glyceraldehyde-3-phosphate dehydrogenase 1 in the nucleus is dependent on the expression SEVEN IN ABSENTIA like 7. These observations suggest that the association of both proteins might result in different biological consequences in plants either through affecting the glycolytic flux or via cytoplasm-nucleus relocation.","palabras_clave":"SINAL7|GAPC|INTERACTION|UBIQUITINATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":263,"idioma_id":4,"titulo":"Omics Approaches for the Engineering of Pathogen Resistant Plants","resumen":"The attack of different pathogens, such as bacteria, fungi and viruses has a negative impact on crop production. In counter such attacks, plants have developed different strategies involving the modification of gene expression, activation of several metabolic pathways and post-translational modification of proteins, which culminate into the accumulation of primary and secondary metabolites implicated in plant defense responses. The recent advancement in omics techniques allows the increase coverage of plants transcriptomes, proteomes and metabolomes during pathogen attack, and the modulation of the response after the infection. Omics techniques also allow us to learn more about the biological cycle of the pathogens in addition to the identification of novel virulence factors in pathogens and their host targets. Both approaches become important to decipher the mechanism underlying pathogen attacks and to develop strategies for improving disease-resistant plants. In this review, we summarize some of the contribution of genomics, transcriptomics, proteomics, metabolomics and metallomics in devising the strategies to obtain plants with increased resistance to pathogens. These approaches constitute important research tools in the development of new technologies for the protection against diseases and increase plant production.","palabras_clave":"OMICS|PLANTS|RESISTANCE|METABOLOMICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":264,"idioma_id":4,"titulo":"Fossil Groups in the Millennium Simulation: from the brightest to the faintest galaxies during the past 8 Gyr.","resumen":"Aims: We investigate the evolution of bright and faint galaxies in fossil and non-fossil groups. Methods: We used mock galaxies constructed based on the Millennium run simulation II. We identified fossil groups at redshift zero according to two different selection criteria, and then built reliable control samples of non-fossil groups that reproduce the fossil virial mass and assembly time distributions. The faint galaxies were defined as having r-band absolute magnitudes in the range [-16, -11]. We analysed the properties of the bright and faint galaxies in fossil and non-fossil groups during the past 8 Gyr. Results: We observed that the brightest galaxy in fossil groups is typically brighter and more massive than their counterparts in control groups. Fossil groups developed their large magnitude gap between the brightest galaxies around 3.5 Gyr ago. The brightest galaxy stellar masses of all groups show a notorious increment at that time. By analysing the behaviour of the magnitude gap between the first and the second, third, and fourth ranked galaxies, we found that at earlier times, fossil groups comprised two large brightest galaxies with similar magnitudes surrounded by much fainter galaxies, while in control groups these magnitude gaps were never as large as in fossils. At early times, fossil groups in the faint population were denser than non-fossil groups, then this trend reversed, and finally they became similar at the present day. The mean number of faint galaxies in non-fossil systems increases in an almost constant rate towards later times, while this number in fossil groups reaches a plateau at z ~ 0.6 that lasts ~2 Gyr, and then starts growing again more rapidly. Conclusions: The formation of fossil groups is defined at the very beginning of the groups according to their galaxy luminosity sampling, which could be determined by their merging rate at early times.","palabras_clave":"methods: numerical| methods: statistical|galaxies: groups: general"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":265,"idioma_id":4,"titulo":"Atlantic Forest replacement by non-native tree plantations: Comparing aboveground necromass between native forest and pine plantation ecosystems","resumen":"Necromass is a critical structural and functional component of forest ecosystems that represents an important and relatively long-lived aboveground forest carbon pool. In the Atlantic Forest of Northern Argentina, a large area of native forest has been replaced by commercial, non-native tree plantations. We hypothesized that total aboveground necromass would be affected by forest conversion. Specifically, we expected a general decrease in necromass with conversion to non-native pine plantations. In five different Pinus taeda plantations (PP) and five native forests (NF) sites in Misiones, Argentina, we quantified the fallen coarse woody debris (CWD: >2 cm diameter) and litter layer (LL: 10 cm in NF (5.4 ± 3.7 Mg ha1), and 2?5 cm in PP (1 ± 0.2 Mg ha1). Coarse woody debris in NF was principally composed of detritus in intermediate to advanced states of decomposition (5.1 ± 3 Mg ha1; 68% of total CWD), while in PP recently dead material accounted for the majority of CWD (0.8 ± 0.5 Mg ha1; 49% of total CWD). Necromass moisture content was similar in both forest ecosystems, and increased as the level of decomposition increased. However, because CWD was more abundant in NF, the water volume retained in NF was four times higher than in PP (6.38 ± 1.3 vs. 1.68 ± 0.5 m3 ha1, respectively). The observed differences in necromass can be explained by the stand characteristics of PP, which are monospecific young systems of short harvest cycles and low quality litter where all aboveground biomass is removed during harvesting. Our findings suggest that NF replacement by PP could have large effects on ecosystem function due to changes in the amount and composition of necromass. Specifically, the predominance of fine detritus in PP likely lowers the residence time of carbon and water storage in detritus, as well as ecosystem biodiversity, while also increasing the risk of natural fires. Management strategies that would increase coarse necromass, such as not removing harvest residues and extending tree harvest age, should be considered.","palabras_clave":"coarse woody debris|litter layer|Pinus taeda|water content"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":266,"idioma_id":4,"titulo":"CG2AA: Backmapping Protein Coarse-Grained Structures","resumen":"Coarse-grained (CG) models allow long-scale simulationswith a much lower computational cost than that of all-atom (AA)simulations. However, the absence of atomistic detail impedesthe analysis of specific atomic interactions that are determinant inmost interesting biomolecular processes. In order to study thesephenomena, it is necessary to reconstruct the atomistic structure fromthe CG representation. This structure can be analyzed by itself or beused as an onset for atomistic molecular dynamics simulations. In thiswork we present a computer program that accurately reconstructs theatomistic structure from CG models from the force field developedin (Hills et al., 2010), using a simple geometrical algorithm.","palabras_clave":"Coarse Grain|Molecular Dynamics|Backmapping"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":267,"idioma_id":4,"titulo":"A 60-million-year Cenozoic history of western Amazonian ecosystems in Contamana, eastern Peru","resumen":"We provide a synopsis of ~60 million years of life history in Neotropical lowlands, based on a comprehensive survey of the Cenozoic deposits along the Quebrada Cachiyacu near Contamana in Peruvian Amazonia. The 34 fossil-bearing localities identified have yielded a diversity of fossil remains, including vertebrates, mollusks, arthropods, plant fossils, and microorganisms, ranging from the early Paleocene up to the late Miocene-?Pliocene (> 20 successive levels). This Cenozoic series includes the base of the Huchpayacu Formation (Fm.; early Paleocene; lacustrine\/fluvial environments; charophyte-dominated assemblage), the Pozo Fm. (middle + ?late Eocene; marine then freshwater environments; most diversified biomes), and complete sections for the Chambira Fm. (late Oligocene?late early Miocene; freshwater environments; vertebrate-dominated faunas), the Pebas Fm. (late early to early late Miocene; freshwater environments with an increasing marine influence; excellent fossil record), and Ipururo Fm. (late Miocene??Pliocene; fully fluvial environments; virtually no fossils preserved). At least 485 fossil species are recognized in the Contamana area (~250 ?plants?, ~212 animals, and 23 foraminifera). Based on taxonomic lists from each stratigraphic interval, high-level taxonomic diversity remained fairly constant throughout the middle Eocene-Miocene interval (8-12 classes), ordinal diversity fluctuated to a greater degree, and family\/species diversity generally declined, with a drastic drop in the early Miocene. The Paleocene??Pliocene fossil assemblages from Contamana attest at least to four biogeographic histories inherited from (i) Mesozoic Gondwanan times, (ii) the Panamerican realm prior to (iii) the time of South America?s Cenozoic ?splendid isolation?, and (iv) Neotropical ecosystems in the Americas. No direct evidence of any North American terrestrial immigrant has yet been recognized in the Miocene record at Contamana","palabras_clave":"Fossil Record|Paleobiology|Stratigraphy|Paleogeography|South America"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":268,"idioma_id":4,"titulo":"Anomalous Values of Gravity and Magnetism in the Western Margin of  Gondwana","resumen":"This research is based on a joint geological and geophysical study performed in the South Central Andes region. We acquired and processed terrestrial and satellite gravity data, as well as terrestrial and aeromagnetic data. Balanced geological cross-sections were constrained by physical properties of rocks (densities and magnetic susceptibilities obtained from field samples and well log). This study was performed in order to interpret a complex region that is still under debate: the location of Famatinian magmatic arc and its boundary with the Cuyania terrain. By means of gravity anomaly we developed direct and inverse models constrained by field data. The existence of a major high-density geological structure was evidenced from these models, located below the Vinchina basin and to the east of Cerro Rajado respectively. The existence of such gravity high could be linked to the boundary between the Famatinian magmatic arc and the accreted Cuyania wedge.","palabras_clave":"Western Gondwana|Famatinian arc|Potential field methods|Western Sierras Pampeanas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":271,"idioma_id":4,"titulo":"ON HIGH-RISE RESIDENTIAL BUILDINGS IN AN OASIS-CITY: THERMAL AND ENERGY ASSESSMENT OF DIFFERENT ENVELOPE MATERIALITY ABOVE AND BELOW TREE CANOPY","resumen":"Urban foresting can affect high-rise buildings in two ways froman environmentalist point of view because building envelopes are exposedto different conditions above and below the tree canopy. Two buildingswere selected as case studies with massive and light envelopes. Weperformed thermal energy analyses in the apartments above and belowtreetops along with interviews of the residents in order to calculate thePredicted Mean Vote (PMV). A view of these cases clarifies that thesefactors greatly influence the occupants and their use of HVAC undernormal conditions. Dynamic models are validated by the Energy Plussoftware and user incidents are excluded in order to evaluate the thermaland energy differences based on variables of materiality and height.These results show that there is variation in energy consumption duringwinter and summer according to materiality of the building envelope:massive building envelopes require more energy consumption in the winter;while, for the summer their consumption is less. In addition, we findthat apartments below the tree canopy take advantage of the benefits ofthe microclimate in the oasis-city with indoor temperatures closer tocomfort ranges as well as lower energy consumption for temperatures inboth summer and winter.","palabras_clave":"OASIS-CITY|HIGH-RISE BUILDINGS |TREE CANOPY |ENVELOPE|MASSIVE AND LIGHT MATERIALITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":272,"idioma_id":4,"titulo":"Apoptosis, proliferation and presence of estradiol receptors in the testes and Bidder's organ of the toad Rhinella arenarum (Amphibia, Anura).","resumen":"The dynamic equilibrium between spermatogonial proliferation and testicular apoptosis determines the progression of spermatogenesis in amphibians. Estrogens and their receptors play a central role in regulating spermatogenesis in vertebrates, and in some species of anurans, estradiol (E2 ) is involved in the regulation of spermatogonial proliferation and apoptosis of germ cells. Bidder´s organ (BO) is a structure characteristic of Bufonidae that has historically been compared to an undeveloped ovary. In adult Rhinella arenarum males, BO is one of the main sources of plasma E2 . The aim of this study was 1) to describe the seasonal variations in testicular apoptosis, spermatogonial proliferation, and cellular proliferation in BO; and 2) to analyze the presence and localization of estrogen receptor â (ERâ) in the testes and BO of R. arenarum. Testicular fragments and BOs from animals collected during the year were labeled with 5-bromo-2´-deoxyuridine (BrdU) and BrdU incorporation was determined using immunohistochemistry. Apoptosis in testicular sections was detected using the TUNEL method, and ERâ localization was assessed using immunohistochemistry in testes and BOs. The results indicate that spermatogonial proliferation is highest during the reproductive season and that cysts of spermatocytes and spermatids undergo apoptosis during the postreproductive season. Furthermore, the proliferation of follicular cells is highest during the reproductive and postreproductive seasons. ERâ was primarily detected by immunolocalization in Sertoli cells, follicular cells, and oocytes. Taken together, these results suggest that cysts that do not form spermatozoa are removed from testes by apoptosis and that estrogens regulate both spermatogenesis and oogenesis in adult males of R. arenarum.","palabras_clave":"ESTRADIOL|TESTIS|BIDDER&#180;S ORGAN|AMPHIBIANS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":274,"idioma_id":4,"titulo":"Tracking eolian dust with helium and thorium: Impacts of grain size and provenance","resumen":"Reconstructions of the deposition rate of windblown mineral dust in ocean sedimentsoffer an important means of tracking past climate changes and of assessing the radiative andbiogeochemical impacts of dust in past climates. Dust flux estimates in ocean sediments havecommonly been based on the operationally defined lithogenic fraction of sediment samples.More recently, dust fluxes have been estimated from measurements of helium and thorium, asrare isotopes of these elements (He-3 and Th-230) allow estimates of sediment flux, and thedominant isotopes (He-4 and Th-232) are uniquely associated with the lithogenic fraction ofmarine sediments. In order to improve the fidelity of dust flux reconstructions based on He andTh, we present a survey of He and Th concentrations in sediments from dust source areas in EastAsia, Australia and South America. Our data show systematic relationships between He and Thconcentrations and grain size, with He concentrations decreasing and Th concentrationsincreasing with decreasing grain size. We find consistent He and Th concentrations in the finefraction (38&#730;S). In the equatorial Pacific, He\/Th ratios are much lower than in extratropicalPacific sediments or potential source areas measured as a part of this study (East Asia, SouthAmerica, Australia) for reasons that are at present unclear, complicating their use as provenancetracers in this region.","palabras_clave":"dust|thorium|helium|isotopes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":276,"idioma_id":4,"titulo":"Milk protein suspensions enriched with three essential minerals: Physicochemical characterization and aggregation induced by a novel enzymatic pool","resumen":"Structural changes of casein micelles and their aggregation induced by a novel enzymatic pool isolatedfrom Bacillus spp. in the presence of calcium, magnesium or zinc were investigated. The effect of cationson milk protein structure was studied using fluorescence and dynamic light scattering. In the presenceof cations, milk protein structure rearrangements and larger casein micelle size were observed. Theinteraction of milk proteins with zinc appears to be of a different nature than that with calcium ormagnesium. Under the experimental conditions assayed, the affinity of each cation for some groupspresent in milk proteins seems to play an important role, besides electrostatic interaction. On the otherhand, the lowest aggregation times were achieved at the highest calcium and zinc concentrations (15 mMand 0.25 mM, respectively). The study found that the faster the aggregation of casein micelles, the lesscompact the gel matrix obtained. Cation concentrations affected milk protein aggregation kinetics andthe structure of the aggregates formed.","palabras_clave":"BACTERIAL ENZYME|CASEIN MICELLE AGGREGATION|STRUCTURAL CHANGES|DIVALENT CATIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":278,"idioma_id":4,"titulo":"Ecological and social consequences of the Forest Transition Theory as applied to the Argentinean Great Chaco","resumen":"Forest transition is the change from net deforestation to net reforestation. According to the Forest Transition Theory (FTT) in its original form, reforestation is triggered by the last stage of socio economic development, when the rural population migrates to urban areas, and forest cover expands naturally on abandoned agricultural fields. The assumptions underlying the FTT have been changed to extrapolate it to the Argentinean Great Chaco (AGC). It is suggested that Indigenous people and low income peasants, who use land inefficiently, should migrate to the urban areas in search of a better life quality. Thus, the abandoned lands could be used for conservation, while the most suitable soils could be destined for food production. However, the subtropical forests in the AGC are highly vulnerable to desertification, as a consequence of rainfall irregularity and high summer evaporation rates. The probability exists that forest recovery does not occur in time scales relevant for conservation. Drawing on research data and bibliography, we tested the validity of the three main assumptions suggested for the Forest Transition Theory as applied to the AGC. Results show that original inhabitants have sustainable land use strategies; rural outmigration is driven by high-input agriculture, which pushes people toward the city skirts; and expansion of intensive agriculture is independent of soils production capacity. We discuss the social and environmental consequences of the proposed assumptions.","palabras_clave":"Deforestation|Development|Indigenous people|Low-income peasants|Intensive agriculture|Multifunctional land use"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":280,"idioma_id":5,"titulo":"EL YACIMIENTO EPITERMAL Ag + Pb (Zn ± Cu) LOMA GALENA, PROYECTO NAVIDAD, CHUBUT, ARGENTINA","resumen":"Loma Galena (100 Moz Ag; 675.000Tn Pb) es uno de los ochodepósitos que constituyen el proyecto minero de Ag + Pb (Cu + Zn) Navidad (42.4°S - 68.81ºO), situadoal sudoeste del Macizo Norpatagónico, en la provincia de Chubut, Argentina. Este depósito con características epitermales está hospedado en rocasvolcánicas y sedimentarias&nbsp; del Jurásicomedio a superior (Formación Cañadón Asfalto) y se formó en un ambiente de riftcontinental activo con un fuerte control estructural y litológico. Los sulfuros ysulfosales (pirita, galena, esfalerita, calcopirita, bornita,tetraedrita-tennantita) tienen cantidades menores a trazas de Ag (Au, Bi) y yacenen: a) enjambres de venas brechadas que cortan andesitas y dacitas frágiles enprofundidad, b) agregados semi-masivos en el contacto entre dacitasautobrechadas y rocas sedimentarias superiores, y c) diseminados en las rocassedimentarias. La alteración hidrotermal temprana de las dacitas en contactocon las venas y brechas incluye calcita, adularia e illita y es probable que sehaya generado de soluciones cloruradas con pH alcalino y altas concentracionesde CO2, a temperaturas &lt;300ºC. La ebullición local y episódica deestos fluidos a lo largo de los conductos ascendentes (fallas) resultó en la precipitaciónde calcita laminar y costriforme como primer relleno de las venas, seguida demineralización multiepisódica de sulfuros de Fe-Pb-Zn con contenidos de Ag (T&lt;240ºC), brechamiento y precipitación de calcedonia coloforme y baritina (T&lt;180 ºC). Las texturas framboidal y coloforme en pirita indicanfluctuaciones bruscas de la temperatura y de la composición del fluidohidrotermal. Durante un nuevo estadio mineralizante, sulfuros y sulfosales deAg-Cu reemplazaron los sulfuros previamente formados, y es probable que hayanestados vinculados con la formación de caolinita y calcedonia en las rocas decaja (fluidos con bajo pH y T &lt;200 ° C). Por último, calcita de grano grueso,calcedonia, baritina, estroncianita y cuarzo precipitaron en vetas y brechas,probablemente de aguas bicarbonatadas descendentes, que también alteraron lasrocas de caja a esmectita y carbonatos de Fe-Mn-Mg. La mezcla de los fluidoshidrotermales ascendentes con fluidos reducidos de las rocas sedimentarias ricasen materia orgánica, debe haber propiciado la generación de un frente redoxfavorable para la precipitación semi-masiva de sulfuros en el nivel medio, lazona más mineralizada del depósito.&nbsp;","palabras_clave":"MINERALIZACUON POLIMETALICA|EPITERMAL|MACIZO NORPATAGONICO|VULCANISMO JURASICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":282,"idioma_id":5,"titulo":"El espinoso objeto de la educación media y la vinculación con el mercado de trabajo. Un estudio de caso en la Ciudad de Mar del Plata","resumen":"El presente artículo es un estudio de caso acerca de las percepciones de los y las estudiantes de escuelas secundarias municipales del Partido de General Pueyrredón acerca de la terminalidad educativa secundaria como instancia de un mejor acceso al mercado de trabajo y a la educación superior. Con una muestra de 763 casos distribuida en 11 escuelas en todo el municipio, y utilizando un relevamiento con escalas de opinión, el estudio utiliza una técnica de regresión lineal que da cuenta de la prevalencia de un enfoque utilitarista basado en la transferencia de insumos de tipo cognitivo y\/o adquisición de habilidades como la valoración positiva predominante, a la vez que esta valoración es más alta cuanto más vulnerable es el barrio en que se inserta la escuela","palabras_clave":"Terminalidad educativa secundaria|percepcion estudiantes|Mercado de trabajo|Acceso Educación Superior"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":283,"idioma_id":4,"titulo":"Vertical oviposition activity of mosquitoes in the Atlantic Forest of Brazil with emphasis on the sylvan vector of yellow fever virus, Haemagogus leucocelaenus (Diptera: Culicidae).","resumen":"This study aimed to assess the vertical patterns of oviposition and temporal changes in the distribution of mosquito species in an area of the Atlantic Forest in Rio de Janeiro State, Brazil, and in particular, the behavior and oviposition of potential yellow fever virus vectors. Mosquito samples were collected from the Ecological Reserve Guapiaçu (REGUA, Brazil), which includes a somewhat disturbed forest, with a large diversity of plants and animals. In all, 5,458 specimens (ten species from seven genera) were collected. Haemagogus leucocelaenus was the most frequently captured species, representing 73% of the specimens collected. Species richness and diversity were the highest in the samples collected from the ground-level ovitraps and decreased with height. Species composition also differed significantly among heights. The largest species differences were detected between ovitraps set at the ground level and those set at 7 m and 9 m; Hg. leucocelaenus, Limatus durhamii, and Limatus paraensis contributed most to these differences. Sampling month and climatic variables had significant effects on species richness and diversity. Species diversity and richness decreased with height, suggesting that the conditions for mosquito breeding are more favorable closer to the ground. Species composition also showed vertical differences","palabras_clave":"Culicidae|Haemagogus|acrodendrophily|yellow fever virus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":285,"idioma_id":4,"titulo":"Reversing the peptide sequence impacts on molecular surface behaviour","resumen":"The protein?s primary structure has all the information for specific protein\/peptide folding and, in many cases, can define specific amphiphilic regions along molecules that are important for interaction with membranes. In order to shed light on how peptide sequence is important for the surface properties of amphiphilic peptides, we designed three pairs of peptides with the following characteristics: (1) all molecules have the same hydrophobic residues; (2) the couples differ from each other in their hydrophilic amino acids: positively, negatively and non-charged; (3) each pair has the same residues (same global molecular hydrophobicity) but the primary structure is reversed in comparison to its partner (retro-isomer), giving a molecule with a hydrophilic N or C-terminus and a hydrophobic C or N-terminus. Using the Langmuir monolayer approach, we observed that sequence reversal has a central role in the lateral stability of peptide monolayers, in the ability of the molecules to partition into the air?water interface and in the rheological properties of peptide films, whereas the peptide?s secondary structure, determined by ATR-FTIR, was the same for all peptides. Reversing the sequence also gives a differential way of peptide\/lipid interaction when peptides are in the presence of POPC lipid bilayers. Our results show how sequence inversion confers a distinctive peptide surface behaviour and lipid interaction for molecules with a similar structure.","palabras_clave":"Peptide Langmuir monolayer stability|peptide retro-isomers|peptide-membrane interaction|Peptide Langmuir rheology monolayer"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":286,"idioma_id":4,"titulo":"Uncertainties in Age and Gender Based Health Risk Assessment for Recreational Bathing: Arsenic in Del Azul Stream, Argentina","resumen":"The aim of this study was to assess the risk associated with recreational bathing at Del Azul stream, Argentina, a water course naturally containing Arsenic. It represents a case study on the carcinogenic risk for bathers and on how the risk varies among age groups and genders analyzing the uncertainties of the model input variables and the risk quantification technique. The risk was probabilistically estimated with the 2D Monte Carlo method considering four age groups (5, 10, 15 and 20 years old) and separate exposure routes: accidental water intake, skin contact and the two combined. Although in all the studied groups the risk levels were within safety limits, differences in risk values were observed among age groups and genders. Accidental water intake during bathing was the most risky exposure route. The risk decreased with age and it was higher in males than in females, with larger differences between the two older age groups. This could be attributed to the difference in the accidental water intake rate associated with the daily duration of the bathing event which varied according to age and gender.","palabras_clave":"ARSENIC WATER POLLUTION|BATHING ACTIVITIES|CANCER RISK|UNCERTAINTY|AGE AND GENDER VARIABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":287,"idioma_id":4,"titulo":"New Chemoenzymatic Synthesis of (±)-N-(2-hydroxyethyl)-N,N-dime thyl- 2,3-bis(tetradecyloxy)-1-propanammonium Bromide (DMRIE)","resumen":"Background: Cytofectins are a class of positively charged lipid molecules that can facilitate the functional entry of polynucleotides, macromolecules, and small molecules into living cells, escaping lysosomal degradation. One of the most potent cytofectins, dimyristoyl Rosenthal inhibitor ether (DMRIE), is presently being used to deliver differents active molecules into animal and human diseased tissues. To our knowledge, two synthetic routes for the preparation of DMRIE have so far been reported. One of them is based on the reaction of epichlorhydrin with either dimethylamine chloride or dimethylamine using an alkaline solution as solvent. The main disadvantage of these routes is the formation of 3-(N,N-diamino)-1,2-propanediol. In summary, the synthetic routes mentioned use epichlorohydrin or glycidol as starting materials, both of which have been described as carcinogenic agents. Additionally, sometimes the reaction conditions are drastic. An alternative route for the preparation of other cytofectins is the use of glycerol as the starting material. Glycerol is a non-carcinogenic compound, but its use as starting material results in an increased number of steps of this reaction, generating an increase in the total time of synthesis and the formation of a greater amount of waste and scrap. Based on the above, here we propose a new chemoenzymatic synthetic strategy using glycerol as a starting material.","palabras_clave":"CATIONIC LIPID|CYTOFECTIN|DMRIE|LIPASE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":288,"idioma_id":4,"titulo":"Role of glucocorticoids in cystic ovarian disease: Expression of glucocorticoid receptor in the bovine ovary","resumen":"The aim of this study was to characterize the expression ofglucocorticoid receptor (GR) in the components of normalbovine ovary and in animals with cystic ovarian disease(COD). Changes in the protein and mRNA expression levelswere determined in control cows and cows with COD by immunohistochemistryand real-time PCR. GR protein expressionin granulosa cells was higher in cysts from animals withspontaneous COD and adrenocorticotropic hormone-inducedCOD than in tertiary follicles from control animals. Intheca interna cells, GR expression was higher in cysts fromanimals with spontaneous COD than in tertiary follicles fromcontrol animals. The increase in GR expression observed incystic follicles suggests a mechanism of action for cortisoland its receptor through the activation\/inactivation of specifictranscription factors. These factors could be related tothe pathogenesis of COD in cattle.","palabras_clave":"BOVINE OVARY|CYSTIC OVARIAN DISEASE |GLUCOCORTICOID RECEPTOR|OVARIAN CYSTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":291,"idioma_id":4,"titulo":"Insights into the Regulation of mRNA Processing of Polycistronic Transcripts Mediated by DRBD4\/PTB2, a Trypanosome Homolog of the Polypyrimidine Tract-Binding Protein","resumen":"Trypanosomes regulate gene expression mostly by post-transcriptional mechanisms, including control of mRNA turnover and translation efficiency. This regulation is carried out via certain elements located at the 3&#8242;-untranslated regions of mRNAs, which are recognized by RNA-binding proteins. In trypanosomes, trans-splicing is of central importance to control mRNA maturation. We have previously shown that TcDRBD4\/PTB2, a trypanosome homolog of the human polypyrimidine tract-binding protein splicing regulator, interacts with the intergenic region of one specific dicistronic transcript, referred to as TcUBP (and encoding for TcUBP1 and TcUBP2, two closely kinetoplastid-specific proteins). In this work, a survey of TcUBP RNA processing revealed certain TcDRBD4\/PTB2-regulatory elements within its intercistronic region, which are likely to influence the trans-splicing rate of monocistronic-derived transcripts. Furthermore, TcDRBD4\/PTB2 over-expression in epimastigote cells notably decreased both UBP1 and UBP2 protein expression. This type of post-transcriptional gene regulatory mechanism could be extended to other transcripts as well, since we identified several other RNA precursor molecules that specifically bind to TcDRBD4\/PTB2. Altogether, these findings support a model in which TcDRBD4\/PTB2-containing ribonucleoprotein complexes can prevent trans-splicing. This could represent another stage of gene expression regulation mediated by the masking of trans-splicing\/polyadenylation signals. #Corresponding author","palabras_clave":"TRYPANOSOMES|DRDB4\/PTB2|TRANS-SPLICING|DICISTRONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":292,"idioma_id":4,"titulo":"Chemical, sensory, and microbiological stability of stored raw peanuts packaged in polypropylene ventilated bags and high barrier plastic bags","resumen":"The purpose of this study was to compare the chemical, microbiological, and sensory stability of raw peanuts packaged in high barrier plastic bags (EVOH) under vacuum and in regular polypropylene (PP) ventilated bags during 60 days of storage at 40 °C. The peroxide value showed a higher increase (from 0.38 to 0.95 meqO2\/Kg) in PP samples than in EVOH samples (from 0.38 to 0.63 meqO2\/Kg) during storage. The highest free fatty acids value (0.60g oleic acid\/100g peanut oil) was reached by EVOH samples at day 60. The samples packaged in PP pouches showed a significantly higher oleic\/linoleic ratio (15.94) and lower iodine value (78.07) with respect to EVOH (13.80 and 80.30, respectively) at the end of storage. A greater decrease of &#945;-tocopherol was observed in PP ventilated bags (from 27.78 to 23.24 mg\/100g oil) than in EVOH bags (from 27.78 to 25.10 mg\/100g oil). At storage day 60, only molds were detected for both peanut samples but EVOH (2900 CFU\/g) showed higher values than PP (2170 CFU\/g). An increase of the cardboard flavor and a decrease of roasted peanutty were greater in PP samples. The EVOH bags preserve raw peanuts with better quality in comparison with PP bags.","palabras_clave":"PACKAGING|PEANUT|PRESERVATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":293,"idioma_id":4,"titulo":"AGING OF ROOF COATINGS. SOLAR REFLECTANCE STABILITY ACCORDING TO THEIR MORPHOLOGICAL CHARACTERISTICS","resumen":"Increasing solar reflectance on roofs is an efficient strategy for urban cooling. The aim of this study is to evaluate how the passage of time affects the thermal behavior of 19 roof tiles and roof paint. The impact of aging is quantified by the change in the Solar Reflectance Index over three years. The results show that the roof coatings evaluated tend to increase the surface temperature between 3.5 °C and 24 °C. The main morphological characteristics that impact the thermal performance of new materials are: color, composition and finish; while for aged materials are: color, finish and shape.","palabras_clave":"ROOF COATINGS|THERMAL AND OPTICAL BEHAVIORS|MORPHOLOGICAL CHARACTERISTICS|STABILITY|AGED"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":295,"idioma_id":4,"titulo":"Early Cretaceous palm pollen tetrads from Patagonia, Argentina","resumen":"Pollen tetrads and monads of spiny pollen grains with close affinities to palms have been found in severallocalities from the Lower Cretaceous (Barremian-Albian) of the Austral Basin (Magallanes), Patagonia(Argentina). When found dispersed, spiny and zonasulcate pollen grains, are commonly referred to thefossil genus Spinizonocolpites Muller, with close affinities to the extant palm Nypa. The Patagonianspecimens were compared with fossil and extant members of the Arecaceae, showing close similaritiesin shape and sculpture with the primitive members of the subfamily Calamoideae. Nypa producestetragonal tetrads different from the tetrahedral tetrads of the Spinizonocolpites-type recovered fromPatagonia. The specimens were studied with LM and SEM. The polarity, aperture orientation and tetradtype allow segregating the Patagonian grains from the Nypoideae and relating it to the Calamoideaesubfamily. These records suggest an antique origin of monocots and a probably initial diversification ofcalamoid palms during the Early Cretaceous in high latitudes of Gondwana. The presence of palmaeduring the Early Cretaceous in southern South America suggests a warm and humid climate, similar tothat found in present days at tropics","palabras_clave":"Gondwana|Patagonia|Austral Basin|Early Cretaceous|Monocots|Palms"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":296,"idioma_id":5,"titulo":"Nuevo método para la evaluación del comportamiento sanitario de variedades de algodón frente a enfermedad azul","resumen":"La enfermedad de origen viral más importante en el cultivo de algodón enSudamérica es la enfermedad azul, y es producida por el Cotton leafroll dwarf virus (CLRDV). El CLRDV es transmitido enforma persistente, circulativa y no-propagativa por el pulgón del algodón Aphis gossypii Glover, no siendo posiblesu transmisión mecánica. En los programas de mejoramiento, la evaluación deresistencia a CLRDV en germoplasma de algodón se realiza mediante lainoculación con áfidos infectivos mantenidos en invernáculo bajo condicionescontroladas durante todo el año. Esta&nbsp;metodología es compleja y limita la cantidad de germoplasma a evaluar.Nuestro grupo ha desarrollado un sistema alternativo de infección mediante laconstrucción de un clon infectivo de cDNA del CLRDV y un método eficiente deinoculación via agroinfección. El clon infectivo del CLRDV logró establecer lainfección en plantas de algodón susceptibles, que desarrollaron los síntomastípicos de enfermedad azul, detectándose la presencia del virus en las hojassistémicas. La técnica de infección desarrollada representa unaherramienta biotecnológica muy importante y podrá utilizarse como sistema deinfección de rutina en los programas de mejoramiento de algodón siendo unmétodo más sencillo y económico que el sistema de pulgones infectivos. El cloninfectivo permitirá acelerar la selección de posibles genes de resistencia y\/otolerancia al CLRDV en el germoplasma de algodón, que puedan ser utilizados enmejoramiento e introgresión en variedades élite.","palabras_clave":"CLRDV|CLON|CDNA|GOSSYPIUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":297,"idioma_id":4,"titulo":"Flow structure at a confluence: experimental data and the bluff body analogy","resumen":"An experimental characterization of the hydrodynamics of amixing interface at an open channel confluence is presented. In the laboratoryexperiments, both a confluence and a cylinder set-up were studied in order tovalidate the bluff body analogy, which has been proposed to characterize the mixinginterface. The experimental characterization included flow visualization andthe computation of the mean flow field, time scales of the coherent structures,and turbulent kinetic energy. The comparison among the two configurationsconfirms the validity of the analogy as similar features were found for themean flow field and time scales of the coherent structures. However,differences in the length of the stagnation zone, the flow velocity deficit,and the turbulence intensity were observed. These differences should be takeninto account when the bluff body analogy is used to characterize the confluencehydrodynamics and to quantify the mixing at the confluence interface.","palabras_clave":"ACOUSTIC DOPPLER TECHNIQUES|COHERENT STRUCTURES|LABORATORY STUDIES|MIXING PROCESS|RIVER CHANNELS CONFLUENCE|VELOCITY MEASUREMENTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":298,"idioma_id":4,"titulo":"Immediate catalytic upgrading of soybean shell bio-oil","resumen":"The pyrolysis of soybean shell and the immediate catalytic upgrading of the bio-oil over an equilibrium FCC catalyst was studied in order to define its potential as a source for fuels and chemicals. The experiments of pyrolysis and immediate catalytic upgrading were performed at 550 C during 7 min with different catalysts to oil relationships in an integrated fixed bed pyrolysis-conversion reactor. The results were compared under the same conditions against those from pine sawdust, which is a biomass source commonly used for the production of bio-oil. In the pyrolysis the pine sawdust produced more liquids (61.4%wt.) than the soybean shell (54.7%wt.). When the catalyst was presented, the yield of hydrocarbons increased, particularly in the case of soybean shell, which was four time higher than in the pyrolysis. The bio-oil from soybean shell produced less coke (between 3.1 and 4.3%wt.) in its immediate catalytic upgrading than that from pine sawdust (between 5 and 5.8%wt.), due to its lower content of phenolic and other high molecular weight compounds (three and five times less, respectively). Moreover, soybean shell showed a higher selectivity to hydrocarbons in the gasoline range, with more olefins and less aromaticthan pine sawdust. ","palabras_clave":"SOYBEAN SHELL|PYROLYSIS|IMMEDIATE CATALYTIC UPGRADING|FUELS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":299,"idioma_id":4,"titulo":"A striking case of deceptive woodpecker colouration: the threatened Helmeted Woodpecker Dryocopus galeatus belongs in the genus Celeus.","resumen":"The Helmeted Woodpecker Dryocopus galeatus is a threatened species of the Atlantic Forest in southeastern South America. It has traditionally been placed in the genus Dryocopus, but it shows similarities in plumage and structure with woodpeckers in the genus Celeus. We sequenced mitochondrial and nuclear DNA that was sampled from live captured Helmeted Woodpeckers. We found that the Helmeted Woodpecker has a phylogenetic position embedded within the genus Celeus, and recommend its taxonomic treatment as Celeus galeatus. The Helmeted Woodpecker belongs to a clade within Celeus that includes Kaempfer?s Woodpecker C. obrieni, Rufous-headed Woodpecker C. spectabilis, and Cream-coloured Woodpecker C. flavus. It has the southernmost distribution range of the woodpeckers in this clade. The Helmeted Woodpecker is sympatric throughout its range with LineatedWoodpecker Dryocopus lineatus and Robust Woodpecker Campephilus robustus and these species from three different genera show a remarkable convergence in plumage colours and patterns. With the inclusion of Helmeted Woodpecker in Celeus, this genus has four out of 15 species on the International Union for Conservation of Nature (IUCN) red list, a higher proportion of red listed species than in the woodpecker family overall.","palabras_clave":"PICIDAE|MOLECULAR PHYLOGENY|ATLANTIC FOREST|THREATENED BIRD|PLUMAGE CONVERGENCE|MIMICRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":301,"idioma_id":4,"titulo":"Effects of Dark Brooders on Behavior and Fearfulness in Layers","resumen":"Simple Summary: Chicks require heat to maintain body temperature during the first weeks after hatch. Heat is normally provided by use of heating lamps or whole-house heating, but an alternative is dark brooders, i.e. horizontal heating elements equipped with curtains. The effects of providing layer chicks with dark brooders during the brooding period on behavior and fearfulness were investigated. Brooders resulted in chicks showing less locomotive activity, feather pecking and fleeing. Also, a long-term reduction of fearfulness in brooder birds was found. Results support the suggestion that rearing with dark brooders can be a successful method of reducing or preventing some of the major welfare  problems in layers.Acknowledgments: We would like to thank MHJ Agroteknik A\/S for the development of the water-heated brooders and the technical support during the installation. We also thank Laura Alicia Gonzalez for her statistical advice. The work was financed by the Green Development and Demonstration Programme (GUDP), established under the Ministry of Food, Agriculture, and Fisheries, Denmark. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina, funded Diego A. Guzman?s postdoctoral stay in Denmark.","palabras_clave":"BROODERS|TONIC INMOBILITY|BEHAVIOUR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":302,"idioma_id":4,"titulo":"Radiation Sensor Based on MOSFETs Mismatch Amplification for Radiotherapy Applications","resumen":"In this paper we present a new dosimeter based on a pair of thick gate oxide MOSFET sensors. A differential circuit topology with a feedback loop provides stabilized output with selectable sensitivity amplification for real time in vivo dosimetry. Radiation response shows a wide linear output range and an effective thermal rejection. These properties make this circuit suitable for dose control in radiotherapy applications.","palabras_clave":"IONIZING RADIATION|MOSFET DOSIMETER|RADIOTHERAPY|SOLID-STATE DETECTORS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":303,"idioma_id":5,"titulo":"Sarmiento y sus precursores","resumen":"Debate con artículo de Ariel de la Fuente sobre los estudios sobre el Facundo de Sarmiento.Así es, Sarmiento habla por lo aprendido; escribe lo que otros también piensan o han pensado; pero lo pone en una estructura, en un plan de obra y en un proyecto estético y político que les da al material, a los elementos y a la figura de autor una dimensión cuya originalidad no radica en la creatio ex nihilo, sino en los nuevos agenciamientos. Sarmiento no es Funes el memorioso. No solo porque su memoria no puede retener todo lo leído al pie de la letra y en su totalidad; tampoco porque su percepción o su memoria lo condenen a duplicar el mundo, sino porque ?por suerte? Sarmiento puede hacer lo que Funes no: puede pensar.","palabras_clave":"Sarmiento"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":305,"idioma_id":4,"titulo":"Prevalence of entomophthoralean fungi (Entomophthoromycota) of aphids in relation to developmental stages","resumen":"BACKGROUND: Transmission of fungal pathogens of aphids may be affected by the host developmental stage. Brassica and Lactuca sativa L. crops were sampled in Santa Fe, Argentina, to determine the prevalence of fungal-diseased aphids andinvestigate the differences between developmental stages of aphids.RESULTS: The fungal pathogens identified were Zoophthora radicans (Bref.) A. Batko, Pandora neoaphidis (Remaud. & Hennebert)Humber and Entomophthora planchoniana Cornu. Their prevalence on each crop was calculated. The numbers of infected aphids were significantly different between the different developmental stages on all crops except B. oleracea var. botrytis L.CONCLUSIONS: The entomophthoralean fungi identified are important mortality factors of aphids on horticultural crops in Santa Fe. The numbers of infected nymphs and adults were significantly different, nymphs being the most affecteddevelopmental stage.","palabras_clave":"aphids|entomophthoralean fungi|developmental stages|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":306,"idioma_id":5,"titulo":"IMPACTO DE LA APLICACIÓN PROLONGADA DE UREA SOBRE BACTERIAS NITRITANTES DE UN ARGIUDOL TÍPICO, ARGENTINA","resumen":"La oxidación del amoníaco a nitrito constituye un paso crítico en el ciclo del nitrógeno (N) y es realizado por las bacterias oxidantes del amoníaco (BOA) o Nitritantes. El manejo agrícola puede afectar la comunidad de las BOA a través del uso prolongado de fertilizantes nitrogenados como la urea, cuya aplicación tiende a aumentar la acidez del suelo. El tamaño, actividad, composición de las BOA y variables químicas de suelo fueron investigadas luego de 12 años de fertilizaciones con urea. El ensayo presenta un diseño en bloques completos aleatorizados con tres repeticiones sobre un suelo Argiudol típico de Marcos Juárez, Sudeste de Córdoba, Argentina. Los tratamientos fueron: A como control sin aplicación; B y C con 95 y 165 kg ha-1 de urea como fuente de N, respectivamente. Se realizaron dos muestreos: previo a la siembra y en postcosecha de maíz. Para la caracterización de la comunidad de BOA se utilizaron los métodos del número más probable, shaken soil slurry, reacción en cadena de la polimerasa y electroforesis en gel de gradiente desnaturalizante. La fertilización con urea disminuyó el pH del suelo, aumentó la abundancia y diversidad de las BOA pero no produjo cambios significativos en la actividad nitrificante potencial. La estructura de la comunidad de las bacterias nitritantes estuvo dominada por miembros del Grupo 3 de Nitrosospira en todos los tratamientos. Los resultados obtenidos indican que la fertilización con urea a largo plazo en un Argiudol típico representó una fuente de sustrato más que un factor limitante para las BOA. El efecto de la fertilización fue más evidente en el muestreo previo a la siembra de maíz.","palabras_clave":"FERTILIZACIÓN NITROGENADA|PROPIEDADES QUÍMICAS DEL SUELO|BACTERIAS OXIDANTES DEL AMONÍACO|ELECTROFORESIS EN GEL DE GRADIENTE DESNATURALIZANTE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":309,"idioma_id":4,"titulo":"Phenotypic Variability and Heritability of the Cephalic Region of Caiman latirostris","resumen":"The study of the cephalic shape of crocodilian is relevant in the fields of ecology, systematics, evolution and conservation. Therefore, the integration of geometric analysis within quantitative genetics allows the evaluation of the inheritable shape components. In this study the dorsal cephalic region of 210 Caiman latirostris hatchlings was analyzed from seven populations in Santa Fe,Argentina, to detect intra and inter-population phenotypic variability and to determine the heritability of biological shape and size, using newly available geometric morphometric tools. The principal component analysis showed two configurations of cephalic shape that could be related to sexual dimorphism. In the canonical variate analysis, Procrustes distances between groups indicated that there are differences in shape among populations. Furthermore, the method of partial least squares indicated a covariation between cephalic shape and environmental variables. Regarding the estimates of the heritability of biological shape and size, high values were obtained, which means that the components of these features are susceptible to the selection pressures. With respect to size (centroid size), there were significant differences among populations. It was observed that those populations which were exposed to a greater number of days at natural incubation and at higher temperatures resulted in larger cephalic size. Due to the fact that C. latirostris populations are subject of sustainable use programs, these results should be considered, mainly the relationship between incubation temperature and susceptibility of populations to artificial selection pressures. Probably these findings in terms of size, shape and heritability in this species could contribute to develop and enhance management, breeding and sustainable use programs.","palabras_clave":"broad-snouted caiman|morphology|quantitative genetics|phenotypic variability"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":310,"idioma_id":4,"titulo":"First fossil predaceous diving beetle from the Late Pleistocene of Buenos Aires, Argentina","resumen":"Late Pleistocene outcrops exposed in Buenos Aires Province, Argentina, represent one of the most informative sources for paleoecological studies on South American fauna and flora. Several proxies have been used for the study of Pleistocene environmental conditions in the Pampean region. Only a few studies, however, were based on paleoentomological data. Dytiscids are the largest family of water beetles. The aim of this study is to present the first record of a diving beetle (Megadytes (Paramegadytes) glaucus (Brullé, 1837)) from late Pleistocene beds of Buenos Aires Province, and to provide new data on the paleoenvironmental conditions prevailing in the region at that time.","palabras_clave":"FOSSIL DIVING BEETLE|MEGADYTES GLAUCUS|LUJÁN FORMATION|LATE PLEISTOCENE|BUENOS AIRES PROVINCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":311,"idioma_id":5,"titulo":"Ocurrencia de Pseudoboa nigra (Duméril, Bibron & Duméril, 1854)  en la República Argentina (Serpentes: Dipsadidae)","resumen":"El género Pseudoboa comprende seis especies de serpientes que se distribuyen en gran parte de América del Sur, oeste de Panamá, y en las islas Tobago y Granada. Se confirma la presencia en la República Argentina de Pseudoboa nigra, la cual había sido excluida de las listas de especies de serpientes de este país por no contar con material de referencia. Con este registro se alcanzan las 128 especies citadas para la ofidiofauna argentina.    Abstract  The genus Pseudoboa is composed by six species of snakes widely distributed in most of South America, western Panama, and the Tobago and Grenada islands. Due to lack of voucher material, Pseudoboa nigra was excluded from the snakes species lists from Argentina. Here, its presence is confirmed, increasing to 128 the snake species number known for this country.","palabras_clave":"Argentina,| Pseudoboini|Distribución"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":312,"idioma_id":4,"titulo":"Physicochemical and functional properties of cowpea protein isolates treated with temperature or high hydrostatic pressure","resumen":"The effect of thermal (TT, 70 and 90 ºC) and high hydrostatic pressure (HHPT, 200, 400 and 600 MPa) treatments on physicochemical and functional properties of cowpea protein isolates (CPI) extracted at pH 8.0 (A8) and pH 10.0 (A10) was analyzed. The pH of protein extraction affected some physicochemical properties (surface hydrophobicity (Ho) and denaturation temperature), without affecting the functional properties. Treatments led to the formation of soluble protein aggregates stabilized by disulfide bonds, especially with TT at 90 ºC. TT and HHPT shifted the wavelengths of maximum emission to red and to blue, respectively. All treatments increased the Ho and decreased the denaturation enthalpy change, indicating protein unfolding and denaturation. HHPT was more efficient than TT to enhance the gelation capacity and water holding capacity. Interestingly, treated and untreated CPIs exhibited high values of solubility (72-97%). TT and HHPT induced larger changes in the physicochemical and functional properties of A8 proteins as compared to A10. Remarkably, functional properties were improved from the less energetic treatments (70 ºC, 200 MPa).  Industrial relevance: The comparison between treatments (one traditional and one corresponding to an emerging technology) gives information about the possibility of obtaining modified proteins for different functional purposes. The modified cowpea protein isolates may be used in beverages because of high solubility, in desserts because of gel formation capacity and\/or as additives in other foodstuff because of improved water holding capacity. This knowledge would increase the added value of a local production currently marketed without processing.","palabras_clave":"Legume protein|High hydrostatic pressure treatment|Thermal treatment|Cowpea protein isolate"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":314,"idioma_id":5,"titulo":"El canciller argentino Miguel Angel Zavala Ortiz y la revisión del principio de no intervención en la Argentina de la década de 1960.","resumen":"Este artículo desarrolla la reformulación del principio de no intervención realizada por el canciller Miguel Ángel Zavala Ortiz, en el período de recrudecimiento de la Guerra Fría. Especialmente, estudia  cómo dicha reformulación fue utilizada como justificación para algunas de las posiciones adoptadas por la Argentina durante la presidencia de Arturo Illia. Por ejemplo, en los casos de las sanciones a Cuba solicitadas por Venezuela en 1964 y la invasión estadounidense a Santo Domingo en 1965. Esa citada reformulación le permitió al radicalismo del pueblo, partido gobernante, llevar adelante una política dual que intentó conciliar las históricas banderas del yrigoyenismo, con la intención cada vez más evidente de su canciller de acercarse a los Estados Unidos. Esa dualidad permitió ciertos márgenes de autonomía en cuestiones claves pero también fue señalada por la oposición política fue utilizada como argumento para el derrocamiento del presidencia hacia 1966.","palabras_clave":"Zavala Ortiz|política exterior|no intervención|argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":316,"idioma_id":5,"titulo":"¿Qué factores determinan la distribución altitudinal de los peces de ríos tropicales andinos?","resumen":"Altitudinal gradients represent an appropriate system to assess whether there is a relationship between richness patterns, environmental variables, and the ecological processes that determine the species type and number inhabiting a given area. In mountain streams freshwater fishes, the most prevalent relationship is a monotonic decrease in species richness with elevation. The objective of this study was to evaluate four hypotheses that can explain the negative relationship between local fish species richness and altitude, 1) the hypothesis of decreasing energy availability, 2) the hypothesis of increasing climate severity, 3) the hypothesis of habitat diversity, and 4) the hypothesis of isolation by physical severity of the environment. Fish and macro-invertebrates were collected following standard methods from 83 sites (between 200-4 000 meters) of two river basins in the Bolivian Amazon. The first hypothesis was tested by analyzing relationships between the density of macro-invertebrates, the richness of invertivorous fish species and altitude; while the second and third hypotheses were assessed by a multiple regression analysis (GLM) between fish species richness and several local and regional factors. Besides, assemblage dissimilarity between sites along the altitudinal gradient was analyzed using &#946;sim and &#946;ness indices. Fish richness decreases linearly with increasing altitude. The density of macro-invertebrates tends to increase at higher altitudes, contrary to invertivorous fish species richness, suggesting that energy availability is not a limiting factor for fish species colonization. The GLM explained 86% of the variation in fish species richness, with a significant contribution of water temperature, maximum slope in the river mainstem, and stream width. There is a higher species turnover (&#946;sim) between sites at low elevation. Inversely, &#946;ness shows higher values in the upper parts, corresponding to change in assemblages mainly due to species loss. Taken together, these results suggest that climatic and physical severities create strong barriers to colonization, further explaining the decrease in fish richness along the altitudinal gradient.","palabras_clave":"Species richness|bolivian Amazon|mountain streams|maximun slopes in the main river"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":317,"idioma_id":4,"titulo":"Harmful effects of dermal intake of chlorpyrifos, 2,4-D and glyphosate in common toad Rhinella arenarum (Anura: Bufonidae)","resumen":"Amphibians have complex life cycles with aquatic and terrestrial life and uncovered skins, therefore they are exposed to chemical contamination, where dermal exposure is a significant route for pesticide uptake in both habitats. In this study, measurements in blood samples such as levels of butyrylcholinesterase (BChE), carboxylesterase (CbE), glutathione S-transferases (GST), thiobarbituric acid reactive substances (TBARS), modified alkaline comet assay (ACA) for detection of oxidized bases (FPG and Endo III sites), as well as the ratio of heterophils and lymphocytes (H\/L), were evaluated as non-destructive biomarkers to monitor dermal pesticide exposure in male toads of Rhinella arenarum. Toads were exposed to a solutions containing a nominal concentration of insecticide chlorpyrifos (CPF, 10 mg\/L), and herbicides 2,4-D and glyphosate (GLY) (20 mg\/L, respectively). After 48-h of exposure, the levels of plasma B-sterases (BChE and CbE) were inhibited (55 % and 43%, respectively) in toads exposed to CPF. Also, the activity of GST was inducted for dermal exposure to 2,4-D, as well as the levels of TBARS due to CPF exposure. Besides this, CPF and 2,4-D exposure induced oxidative DNA damage, and the H\/L ratio decreased for the both herbicide exposures. Our results showed that exposure via dermal uptake to CPF, 2,4-D, and GLY in the common toad R. arenarum induced neurotoxicity, oxidative stress and immunological depression. Thus, non-destructive blood biomarkers employed inour study (B-esterases, GST, levels of TBARS, ACA, and H\/L ratio) might be used as predictors in health and ecological risk assessment of amphibian populations exposed to OP insecticides and herbicides.","palabras_clave":"Amphibians |2,4-D |Glyphosate|Blood nondestructive parameters|Dermal exposure|Chlorpyrifos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":320,"idioma_id":4,"titulo":"Aroma compounds generation in citrate metabolism of Enterococcus faecium: Genetic characterization of type I citrate gene cluster","resumen":"Se describe el metabolismo de citrato en Enterococcus faecium, las cepas fueron aisladas de quesos argentinos y se describe la diversidad relacionada a este metabolito vinculado a la formacion del aroma de los derivados lacteos","palabras_clave":"Enterococcus faecium|citrate metabolism|aroma production"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":321,"idioma_id":5,"titulo":"La dramatización y la narrativa en el aula universitaria como elemento motivador","resumen":"La deserción y el desempeño académico de los estudiantes son motivo de preocupación constante en el ámbito universitario. La falta de motivación es señalada como una de las causas primeras del deterioro y uno de los problemas más graves del aprendizaje. Con el propósito de incentivar la motivación en mejora del desempeño académico de los alumnos, en este trabajo presentamos algunas acciones relacionadas con la intervención pedagógica basadas en la dramatización de fenómenos científicos y la utilización de la Historia de la Ciencia. Las mismas se implementaron durante la explicación del principio de inercia en la clase de Física 1 de la Facultad de Ingeniería de la Universidad Nacional de Mar del Plata (Argentina).","palabras_clave":"ENSEÑANZA DE LA FISICA|MOTIVACION|HISTORIA DE LA CIENCIA|DRAMATIZACION|PRINCIPIO DE INERCIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":323,"idioma_id":4,"titulo":"Structural study of the ovary, oogenesis and brooding in Tonicia lebruni (Polyplacophora Chitonidae) from Patagonia","resumen":"Tonicia lebruni, a common, lower intertidal and subtidal chiton inhabiting Patagonianrocky shores, is a gonochoristic iteroparous species producing large eggs( 400 lm in diameter), which are fertilized and brooded within the pallialgroves until released as juveniles. A free larval stage is absent, despite this, T. lebruniis widely distributed along the south-western Atlantic. At Puerto Deseado,T. lebruni has a marked seasonality in the reproductive cycle, reproducing onlyonce a year. The reproductive period is quite short and defined in time: spawningand brooding take place during the late austral winter and beginning ofspring. Recovery of the female gonad starts very soon after spawning. Oogenesistakes about 10?11 months for completion. Brood size is correlated with lengthof maternal individual. The number of embryos per brood varied between 785and 5945. Extensive resorption of abortive eggs is viewed as related to limitationof space available for brooding. The egg hull is formed by a large number of minutepentagonal or hexagonal plates each one bearing a short spine bent onto theegg surface. The morphology and the surface of the hull could contribute to thecohesiveness of the brooded egg mass within the pallial grooves.","palabras_clave":"Polyplacophora| Tonicia lebruni|oogenesis|oosorption|brooding"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":324,"idioma_id":5,"titulo":"Interrogantes sobre las atribuciones de poder: una aproximación empírica","resumen":"El artículo describe y analiza los modos como los estudiantes de sociología de la Universidad Nacional de Mar del Plata y los trabajadores de la industria del pescado de la misma ciudad, se representan y evalúan quanta de poder en personalidades de la política, la economía y la cultura. Las representaciones y concepciones del poder evidencia la existencia de un territorio de disputa y confrontación, que permite observar dónde y cuánto ciertas estructuras sociales se cristalizan en representaciones y juicios morales. Asimismo, el trabajo discute problemas teórico-metodológicos y epistemológicos que presenta la investigación empírica de la dimensión poder. En tanto el poder refiere al ámbito constitutivo de relaciones sociales, la observación de procesos sociales de atribución de poder exige elaborar instrumentos cada vez más precisos, dando cuenta tanto de sus virtudes como de sus falencias.","palabras_clave":"PODER|REPRESENTACIONES|TRABAJADORES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":326,"idioma_id":4,"titulo":"Differential risk perception of rural and urban Burrowing Owls exposed to humans and dogs","resumen":"Urban areas expose wildlife to an array of novel predators, amongst which, humans and dogs are highly frequent. Thus, wild animals living in urban areas are forced to invest more time and energy in defence behaviours, which depend on how the risk is perceived and assessed. We experimentally tested whether Burrowing owls coming from rural and urban habitats showed differences in behavioural responses when facing humans and domestic dogs. We measured &#64258;ight initiation distances (FIDs), nest returning, and aggressiveness level when owls faced a human and a human with a dog walking towards them. Our results showed that urban owls recognise a human with a dog as a greater threat than a human alone, thus indicating that fear of domestic animals should be considered as affecting owls? settlement in cities and towns. On the other hand, rural owls perceived human and dogs as similar threats, but showed higher FIDs, less aggressiveness, and lower tendency to return to the nest than urban owls in both treatments. These &#64257;ndings emphasize the importance of modi&#64257;ed habitats in modelling the response of urban and rural owls to predators and represent another step in the explanation of how wild animals assess and respond to threats associated with living in urbanized environments.","palabras_clave":"Athene cunicularia|Flight initiation distance|Aggressiveness|Behaviour|Predators"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":327,"idioma_id":4,"titulo":"Influence of processing conditions on morphological, thermal and degradative behavior of nanocomposites based on plasticized poly(3-hydroxybutyrate) and organo-modified clay","resumen":"Polymer nanocomposites, based on a bacterial biodegradable thermoplastic polyester, poly(hydroxybutyrate) (PHB), and unmodified montmorillonite Cloisite Na+ (CNa) and chemically modified Cloisite 15A and 93A (C15A and C93A), were prepared through a solution route. The nanostructure has been established through X-ray diffraction (XRD), while the nanocomposites were characterized by differential scanning calorimetry (DSC), contact angle measurements, andthermogravimetric (TGA) analysis. Disintegrability in composting conditions has been tested at certain times (0, 7, 14, 21, 28 and 35 days at 58 °C) and the effect of different nanoclays on the properties of biodegraded films was deeply investigated. XRD results suggest a better dispersion for C15A and C93A based nanocomposites that present also a more surface hydrophobic nature respectto PHB matrix and PHB nanocomposite loaded with unmodified Cloisite. This result is in accord with disintegrability behavior of PHB nanocomposites. Visual bservation, chemical, thermal and morphological investigations proved that the disintegration in composting conditions was faster for PHB_4CNa respect to the systems loaded with modified clays suggesting the possibility to modulate the disintegrability capacity of PHB selecting a specific filler.","palabras_clave":"POLY(3-HYDROXYBUTYRATE) |NANOCLAY|PLASTICIZER|DISINTEGRABILITY COMPOST"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":328,"idioma_id":4,"titulo":"The role of life goals in successful aging.","resumen":"Personal goals are conscious mental representations of states that a personwants to achieve, maintain or prevent in future time. Goals are important in all stages of life, and precisely in old age, providing meaning to our evolutionary path, and guidance to a desired future. The aim of this article is to explain the concept of life goals, their importance in people's lives and their evolution over time. We will analyze the main theories about the changes and self-regulatory mechanisms of goals. Finally, we will introduce the empirical results of a research conducted in Mar del Plata, Argentina, where the content and direction of life goals in different age groups were explored. The results indicate that both young adults and older people have different occupational and interpersonal goals. While in both groups many goals are focused on achieving something new, seniors outperform the other group in the proportion of goals focused on maintenance, which coincides with different theories. This data can guide future community actions with this age group","palabras_clave":"Goals;  |Old age; |Youth;|Self-regulation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":329,"idioma_id":5,"titulo":"Infancia, Juego y Genero","resumen":"El entorno provee, para la humanización de los seres, de un conjunto de representaciones que le permiten sujetarse a un orden establecido, asimilar aquellos elementos que lo sacan de la extrañeza del mundo y los anclan a él, dentro de estas representaciones se encuentran las referidas al géneroEsta presentación posee como objetivo precisar algunas cuestiones de género, en especial en relación con los estereotipos de género tradicionales delineados desde el sistema patriarcal y su pervivencia en la actualidad, sostenidos a partir de determinadas producciones culturales como los medios de comunicación y los juegos.Estas  producciones posibilitan la incorporación de ciertos modos de hacer, de sentir y de pensar diferenciales entre niños y niñas, pero siempre con la tendencia a que la distribución de bienes materiales y simbólicos generados en la vida grupal sea desigual entre unos y otras, haciéndolos no solo parte sino también partícipes de esta operatoria de actualización permanente de lo prescripto.","palabras_clave":"INFANCIA|GENERO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":330,"idioma_id":5,"titulo":"Una estrategia innovadora en la enseñanza universitaria.  Clases teórico-prácticas articuladas en Geografía de Europa y Oceanía","resumen":"Los contenidos quecorresponden a la asignatura Geografía de Europa y Oceanía, de la carrera deProfesorado y Licenciatura en Geografía, se constituyen en el foco de lapropuesta didáctica-pedagógica desarrollada como estrategia de enseñanza en elaula universitaria. La propuesta consiste en el desarrollo de clases teóricas yprácticas articuladas, donde se trabajan dos ejes simultáneos: lo disciplinar ylo metodológico. Como docentes responsables del dictado de esta asignatura, nuestraplanificación incluye la enseñanza de los contenidos específicos y, al mismotiempo, el desarrollo de &nbsp;actividades vinculadascon el campo profesional de los futuros profesores e investigadores, tal comoestá estipulado en el Campo de las Prácticas en los respectivos planes deestudios.La voz de los estudiantes se constituye en unaporte clave para evaluar el trabajo cotidiano en el aula. Nos permitedeconstruir nuestras prácticas pedagógicas y evaluar la aplicación de estapropuesta de articulación entre teoría y práctica. Se incluyen en el desarrollode este artículo, los testimonios de nueve estudiantes que cursaron Geografíade Europa y Oceanía en 2014. Esta estrategia de repensar la organización deldesarrollo de las actividades teórico-prácticas es un aporte a la formación enel campo profesional.","palabras_clave":"GEOGRAFIA DE eUROPA Y OCEANÍA|ENSEÑANAZA|ARTICULACIÓN|CLASES TEÓRICO-PRÁCTICAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":331,"idioma_id":5,"titulo":"Aventuras literarias de lo político. Consideraciones sobre una dupla con historia","resumen":"    Mi interés apunta a seguir las aventuras que la política corre al inmiscuirse en el universo literario, de  los modos literarios de hacer política, o de un tipo de escritura que muestra  lo que Lacan llamó orientación hacia lo real. Porque si bien Lacan decía que lo  real no cesa de no escribirse, es imposible de representar, de simbolizar y por  lo tanto de pensar, hay escritores que bordean lo real, lo tocan.  Esta será mi perspectiva para leer una zona de la obra de Castelnuovo. Mi  intención es ahondar sobre lo que llamo una lengua heterogénea para anudar  relaciones posibles entre literatura y la política. Este recorte me permitirá  avanzar en algunas hipótesis porque mi interés se centra en la producción de la  década de 1920 y parte de 1930, momento en que el uso de distintos tipos de  saberes configura una escritura peculiar, de raíz fuertemente anarquista.                         ","palabras_clave":"la política y lo político|elías castelnuovo|lo real|literatura argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":332,"idioma_id":4,"titulo":"A novel combination of experimental design and artificial neural networks as an analytical tool for improving performance in thermospray flame furnace atomic absorption spectrometry","resumen":"In this work, we present the combined effect of artificial neural networks (ANN) and experimental design as a new and suitable analytical tool for improving the performance of thermospray flame furnace atomic absorption spectrometry (TS-FFAAS) using Mg as leading case. To this end, mixtures of different amounts of methanol, ethanol and i-propanol in water were assayed as carriers at different flow rates and different flame stoichiometries (air\/acetylene ratios). Different levels of these variables determined the experimental domain, consisting in a cube which was divided into eight identical cubical regions that allowed increase the number of available experimental points. A Box-Behnken design (BBD) was employed in each one of the regions. The name Multiple Box-Behnken design (MBBD) was given to this new approach. Then, the features of ANN were exploited to find the optimum conditions for conducting Mg determination by TS-FFAAS. The prediction capability of ANN was examined and compared to the least squares (LS) fitting when applied to the response surface method (RSM). The suitability of the new approach and the implications on TS-FFAAS analytical performance are discussed.","palabras_clave":"Experimental design|Thermospray flame furnace atomic absorption spectrometry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":333,"idioma_id":5,"titulo":"Propiedades fotosensibilizadoras de &#946;-carbolinas: daño al ADN en condiciones intra- y extracelulares","resumen":"En este trabajo se presenta un análisis comparativo de la capacidad que muestran ciertas b-carbolinas (bCs) de inducir daño fotosensibilizado en el ADN. Para ello se realizó un análisis cinético y se caracterizaron los fotoproductos formados. Se compararon los perfiles de daño observados en condiciones extra- e intracelulares y se evaluó el potencial genotóxico de estos alcaloides sobre células eucariotas. Los datos aquí recopilados muestran que las bCs actúan como fotosensibilizadores en células mamíferas.","palabras_clave":"Alcaloides|Pirido-indoles|Foto-oxidación|Dímeros de pirimidina|fotosensibilización|Especies Reactivas del Oxígeno"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":334,"idioma_id":4,"titulo":"Surface interactions, thermodynamics and topography of binary monolayers of Insulin with dipalmitoylphosphatidylcholine and 1-palmitoyl-2-oleoylphosphatidylcholine at the air\/water interface.","resumen":"The molecular packing, thermodynamics and surface topography ofbinary Langmuir monolayers of Insulin and DPPC(dipalmitoylphosphatidylcholine) or POCP (palmitoyloleylphosphatidylcholine)at the air-water interface on Zn2+ containingsolutions were studied. Miscibility and interactions were ascertained bythe variation of surface pressure-mean molecular area isotherms, surfacecompressional modulus and surface (dipole) potential with the filmcomposition. Brewster angle microscopy was used to visualize the surfacetopography of the monolayers. Insulin forms non-ideal, stable mixed filmswith DPPC and POPC at all mole fractions studied showing unfavorableexcess free energy of mixing. Under compression the films exhibit aviscoelastic or kinetically trapped organization leading to considerablecomposition-dependent hysteresis under expansion that occurs withentropic-enthalpic compensation. The spontaneously unfavorableinteractions of Insulin with DPPC are driven by favorable enthalpy thatis overcome by unfavorable entropic ordering; in films with POPC both theenthalpic and entropic effects are unfavorable. The surface topographyreveals domain coexistence at relatively high pressure showing a stripedappearance. The interactions of Insulin with two major membranephospholipids induces composition-dependent and long-range changes of thesurface organization that ought to be considered in the context of theinformation-transducing capabilities of the hormone for cell functioning.","palabras_clave":"Insulin|Insulin-phospholipid interactions"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":335,"idioma_id":4,"titulo":"Geochemical behavior of an acid drainage system: the case of the Amarillo River, Famatina (La Rioja, Argentina).","resumen":"The Amarillo River (Famatina range, Argentina, ~29° S and ~67° W) is unusual because acid mine drainage (AMD) is superimposed on the previously existing acid rock drainage (ARD) scenario, as a Holocene paleolake sedimentary sequence shows. In a markedly oxidizing environment, its water is currently ferrous and of the sulfate-magnesium type with high electrical conductivity (>10 mS cm-1 in uppermost catchments). At the time of sampling, the interaction of the mineralized zone with the remnants of mining labors, determined an increase in some elements (e.g., Cu ~3 to ~45 mg L-1; As ~0.2 to ~0.5 mg L-1). Dissolved concentrations were controlled by pH, decreasing significantly by precipitation of neoformed minerals  (jarosite and schwertmannite) and subsequent metal sorption (~700 mg kg-1 As, 320 mg kg-1 Zn).Dilution also played a significant role (i.e., by the mixing with circumneutral waters which reduces the dissolved concentration and also enhances mineral precipitation). Downstream, most metals exhibited a significant attenuation (As 100%, Fe 100%, Zn 99%). PHREEQC-calculated saturation indices (SI) indicated that Fe-bearing minerals, especially schwertmannite, were supersaturated throughout the basin. All positive SI increased through the input of circumneutral water. PHREEQC inverse geochemical models showed throughout the upper and middle basin, that about 1.5 mmol L-1 of Fe-bearing minerals were precipitated. The modeling exercise of mixing different waters yielded results with a >99% of correlation between observed and modeled data.","palabras_clave":"acid rock drainage|acid mine drainage|natural attenuation|efflorescent sulfate salts"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":336,"idioma_id":4,"titulo":"The Role of Anxiety Sensitivity in the Relation Between Experiential Avoidance and Anxious Arousal, Depressive, and Suicidal Symptoms Among Latinos in Primary Care","resumen":"The present investigation examined the explanatory role of anxiety sensitivity in the relation between experiential avoidance and anxious arousal, depressive, and suicidal symptoms among Latinos seeking health services at a primary healthcare facility. Participants included 138 adult Latinos (86.2 % female; M = 38.4, SD = 10.8 and 97.8 % used Spanish as their first language). Results indicated that experiential avoidance was indirectly related to anxious arousal, depressive, and suicidal symptoms through anxiety sensitivity. These observed effects were evident above and beyond the variance accounted for by gender, marital status, educational level, employment status, and negative affectivity. Tests of model specificity [reversing the posited explanatory variable (anxiety sensitivity) and dependent variable(s), respectively] indicated that experiential avoidance is related to anxiety sensitivity, which in turn, is associated with anxious arousal and suicidal symptoms. In regard to depressive symptoms, the relation between experiential avoidance and anxiety sensitivity appears to be reciprocal. The present findings suggest that there is indeed merit in focusing further scientific attention on the interplay between experiential avoidance and anxiety sensitivity in regard to better understanding and possibly intervening to reduce anxiety\/depressive vulnerability among Latinos in primary care settingsT","palabras_clave":"ANXIETY SENSITIVY|MAJOR DEPRESSION|LATINO|PRIMARY CARE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":337,"idioma_id":5,"titulo":"'Mortalidad por enfermedades infecciosas en la Provincia del Chaco durante el período   1999 ? 2012'","resumen":"Las enfermedades infecciosas han constituido la mayor causa de muerte a nivel mundial hasta principios del sigloXX, luego de lo cual se observó una disminución relacionada a los avances en las condiciones de vida de lapoblación, la farmacología y las mejoras del medio ambiente, entre otras causas. Las condiciones socioeconómicasson determinantes de la salud de la población y a pesar de los avances observados en los últimosaños, la provincia del Chaco es una de las más pobres del país. Se realizó este trabajo con el objetivo de describir lamortalidad por causas infecciosas en la provincia durante el periodo 1999-2012 considerando la especial situaciónde vulnerabilidad de la misma. Se trata de un diseño de tipo ecológico, utilizando como unidad de análisis lasdefunciones registradas en la dirección de estadísticas sanitarias y vitales de la provincia del Chaco. Se calculó laproporción de muertes según edad por causas infecciosas y la mortalidad proporcional del período. Se realizó laasignación proporcional considerando las muertes mal definidas según año y edad, y las tasas calculadas sedenominan tasas corregidas. Del total de muertes, 12,6% correspondieron a enfermedades infecciosas.Considerando la tasa de mortalidad corregida y estratificada por edad, se observó un gradiente ascendente apartir de los 5 años de edad; y mayor riesgo en el grupo de 75 años o más. La tendencia de la tasa ajustada a laedad y corregida reconoció un aumento 3,2% por año sin puntos de quiebre en el periodo. La tendencia deaumento no fue uniforme según la edad, dado que existió una tendencia decreciente en los menores de 24 años.La mortalidad por enfermedades infecciosas se encuentra en aumento y afecta especialmente a los mayores de 24años.","palabras_clave":"MORTALIDAD POR CAUSAS INFECCIOSAS|TENDENCIA DE INFECCIONES|MORTALIDAD EN EL CHACO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":338,"idioma_id":4,"titulo":"Immunomodulatory effects of fluoxetine: A new potential pharmacological action for a classic antidepressant drug?","resumen":"Selective serotonin reuptake inhibitors are frequently used antidepressants. In particular, fluoxetine isusually chosen for the treatment of the symptoms of depression, obsessive?compulsive, panic attack andbulimia nervosa. Antidepressant therapy has been associated with immune dysfunction. However, thereis contradictory evidence about the effect of fluoxetine on the immune system. Experimental findingsindicate that lymphocytes express the serotonin transporter. Moreover it has been shown that fluoxetineis able to modulate the immune function through a serotonin-dependent pathway and through a novelindependent mechanism. In addition, several studies have shown that fluoxetine can alter tumor cellviability. Thus, it was recently demonstrated in vivo that chronic fluoxetine treatment inhibits tumorgrowth by increasing antitumor T-cell activity.Here we briefly review some of the literature referring to how fluoxetine is able to modify, for better orworse, the functionality of the immune system. These results of our analysis point to the relevance of thenovel pharmacological action of this drug as an immunomodulator helping to treat several pathologiesin which immune deficiency and\/or deregulation is present.","palabras_clave":"ANTIDEPRESSANT|FLUOXETINE|SEROTONIN|IMMUNE SYSTEM|IMMUNOMODULATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":339,"idioma_id":5,"titulo":"Iluminación y Confort en Aulas y Laboratorios de Carreras Técnicas de Grado Universitario","resumen":"El presente trabajo, analiza el grado deiluminación y confort, de laboratorios yaulas de carreras técnicas universitarias, deacuerdo al marco reglamentario nacionaldel factor de iluminación en espacios detrabajo, considerando a la actividad educativaincluida. Utilizando el protocolo aprobadopor la Superintendencia de riesgosde trabajo, para la medición del factor deiluminación, tomando además las variacionesde temperatura y el factor del viento,como componentes del factor confort, necesariopara una adecuada transmisión yadquisición de los contenidos didácticos.","palabras_clave":"Iluminación|Confort|energía|temperatura"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":342,"idioma_id":4,"titulo":"Screening for cystic fibrosis via a magnetic and microfluidic immunoassay format with electrochemical detection using a copper nanoparticle-modified gold electrode","resumen":"This article describes a microfluidic electrochemicalimmunoassay that features two strategies, viz. (a), the incorporationof magnetic nanoparticles (MNPs) into the centralmicrofluidic channel and acting as a bioaffinity support for theimmobilization of the antibody against the immunoreactivetrypsin (anti-IRT), and (b), the electrodeposition of coppernanoparticles (CuNPs) on a gold electrode. IRT, a marker forcystic fibrosis, is extracted from blood samples onto a diskusing ultrasonication, eluted, and then injected into the detectionsystem where it is captured by anti-IRT-loaded nanoparticles(anti-IRT-Ab-MNPs). Bound IRT is electrochemicallyquantified after addition of HRP-labeled anti-IRT-Ab which,in the presence of H2O2, catalyzes the oxidation of catechol toform o-benzoquinone which is detected at a working potentialof &#8722;150 mV (vs. Ag\/AgCl). The electrochemical response tobenzoquinone is proportional to the concentration of IRT inthe range from 0 to 580 ng&#8901;mL&#8722;1. The coefficients of variationare <5 % for within-day assays, and <6.4 % for between-dayassays. The method was compared to a commercial ELISA forIRT where is showed a correlation coefficient of close to 1. Inour perception, this approach represents an attractive alternativeto existing methods for screening newborns for cysticfibrosis.","palabras_clave":"AMPEROMETRY|CYCLIC VOLTAMMETRY|ELECTRODEPOSITION|HORSE RADISH PEROXIDASE|HYDROGEN PEROXIDE|IMMUNOASSAY|IMMUNOREACTIVE TRYPSIN|MAGNETIC NANOPARTICLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":343,"idioma_id":4,"titulo":"Volatile compounds released by maize grains and silks in response to infection by Fusarium verticillioides and its association with pathogen resistance","resumen":"Many plants respond to fungal infections producing and\/or emitting a specific blend of oxylipins, some of them through the lipoxygenase (LOX) pathway. In vitro bioassays revealed that volatiles from silks and grains of a set of six maize genotypes with variable resistance to Fusarium verticillioides affected fungal growth in different ways. Analyses by solid phase microextraction and GC-MS showed different volatile profiles in silks and grains of each genotype. Susceptible genotypes with higher concentrations of precursor polyunsaturated fatty acids produced more volatiles, mainly C9 compounds, in comparison to moderately resistant ones. Real time PCR from several lipoxygenase transcripts revealed that levels of gene expression depended on the genotype and the inoculation level and suggested that F. verticillioides could use compounds from the 9-LOX pathway to promote infection in grains. On the other hand, volatiles produced by the 13-LOX pathway were more important in moderately resistant genotypes and could be associated to field resistance. Results from this set of genotypes indicate that LOX-regulated volatile compounds might be important in F. verticillioides infection and should be targeted in further research to understand disease resistance.","palabras_clave":"MAIZE|VOLATILES|LOX|FUSARIUM VERTICILLIOIDES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":344,"idioma_id":4,"titulo":"Reseña - Mollie Lewis Nowen, 'Oy, My Buenos Aires. Jewish immigrants and the creation of Argentine national identity' (Albuquerque: University of New Mexico Press, 2013) Pgs. 157, cloth.","resumen":"El libro de Mollie Lewis explora los modos en que los inmigrantes judíos de origen ashkenazi contribuyeron a crear la nueva vertiente ?porteña? en la identidad nacional argentina al tiempo que buscaron mantener la propia identidad. Para ello se centra en el período de mayor inmigración judía, y en el que la Ciudad de Buenos Aires devino el ámbito privilegiado de integración cultural de los inmigrantes al cauce de la vida argentina. Así, al narrar la historia de una de las corrientes migratorias, el libro también nos habla del vertiginoso crecimiento de una ciudad, y de las formas en que esta fue reconfigurada por esa migración, y, merced a su centralidad, los modos en que Buenos Aires reconfiguró la identidad del país. El libro se organiza sobre una serie de ejes que contribuyen a iluminar las formas en que los individuos vivieron  y articularon sus múltiples identidades: las relaciones entre judíos y no judíos, los roles de género, las diferencias generacionales (en las que los usos distintivos del idish y el castellano son un componente decisivo) y los contrastes de clase. Para ello realiza una lectura sistemática de la bibliografía disponible y recurre a fuentes primarias de muy diverso tipo: información censal, archivos policiales, y un amplio arco de obras de poesía, cuentos, novelas e ilustraciones.","palabras_clave":"HISTORIA JUDÍA ARGENTINA|CULTURA JUDÍA|INMIGRACIÓN EUROPEA|CULTURA URBANA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":345,"idioma_id":5,"titulo":"La traducción como capital de distinción editorial: el francés e inglés en las ciencias sociales y humanas en argentina (1990-2014)","resumen":"La traducción y edición de obras de ciencias sociales y humanas constituye un objeto especialmente productivo para reconocer, en primer lugar, las lógicas desiguales de circulación de las ideas entre distintas lenguas, y, en segundo, las especificidades, complementariedades y contradicciones existentes dentro de una misma geografía idiomática. Al mismo tiempo, el estudio socio-histórico de la traducción nos permite visibilizar y comprender las lógicas económicas, políticas y sociales que posibilitan y condicionan la circulación y el conocimiento de tradiciones de pensamiento y autores, cuestiones habitualmente planteadas en términos puramente intelectuales. En este caso particular, nos interesa analizar la traducción y edición de obras de ciencias sociales y humanas  francesas, norteamericanas e inglesas en Argentina, entre 1990 y 2011, a fin de identificar los condicionantes estructurales (internacionales y locales), los actores (editores, traductores, directores de colección, intelectuales, agentes estatales, etc.) y lógicas (materiales, sociales, intelectuales, etc.) que hacen posible y organizan esta circulación. Para ello en este artículo complementamos dos estrategias analíticas: por una parte presentamos el relevamiento y análisis estadístico del conjunto de traducciones realizadas por sellos argentinos durante el período señalado, y, por la otra, nos adentramos en ciertas lógicas específicas de funcionamiento a partir de una serie de entrevistas  a editores, traductores, directores de colección y a la funcionaria de la embajada francesa a cargo del programa de apoyo a la traducción y publicación de obras francesas.","palabras_clave":"CIRCULACIÓN INTERNACIONAL DE LAS IDEAS|EDICIÓN Y TRADUCCIÓN|PENSAMIENTO FRANCÉS|CIENCIAS SOCIALES Y HUMANAS EN ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":346,"idioma_id":5,"titulo":"PROCESOS DE POLITIZACIÓN DEL TRABAJO SOCIAL: EL CASO DE LA FEDERACIÓN ARGENTINA DE ASOCIACIONES PROFESIONALES DE SERVICIO SOCIAL","resumen":"En este artículo se expone un avance del estudio de los procesos de politización de las organizaciones profesionales de Trabajo Social en Argentina, en el marco del Proyecto de Investigación PICTO-UNaM-2011 Nº 0120. Este proyecto es cofinanciado por la Agencia Nacional de Investigación Científica y Tecnológica del Ministerio de Ciencia y Tecnología de la Nación y la Universidad Nacional de Misiones. Este estudio es el primero que se realiza en el país con estas características, dado que en los diversos textos que abordan la historia del Trabajo Social en Argentina, se observa que los procesos de construcción de identidades profesionales, de legitimación como profesión y de construcción de sentido de pertenencia a las organizaciones profesionales, no son abordados en profundidad por los autores y esto no permite conocer las disputas de sentido acerca de la importancia de la asociatividad, los intereses en juego y las concepciones político-ideológicas acerca de la profesión, vigentes en diversos momentos históricos. El período investigado abarca desde la década de 1960 hasta la actualidad y la unidad de análisis es la Federación Argentina de Asociaciones Profesionales de Servicio Social (FAAPSS). En la investigación se utilizan métodos cualitativos y los resultados que se exponen en este artículo corresponden a la lectura y análisis de las actas de la FAAPSS y entrevistas realizadas a informantes claves.","palabras_clave":"ARGENTINA|TRABAJO SOCIAL|ORGANIZACIONES PROFESIONALES|POLÍTICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":347,"idioma_id":4,"titulo":"The pituitary TGFb1 system as a novel target for the treatment of resistant prolactinomas","resumen":"Prolactinomas are the most frequently observed pituitary adenomas and most of them respond well to conventional treatment with dopamine agonists. However, a subset of prolactinomas fails to respond to such therapies and is considered as dopamine agonist-resistant prolactinomas (DARPs). New therapeutic approaches are necessary for these tumors. TGF&#946;1 is a known inhibitor of lactotroph cell proliferation and prolactin secretion, and it partly mediates dopamine inhibitory action. TGF&#946;1 is secreted to the extracellular matrix as an inactive latent complex, and its bioavailability is tightly regulated by different components of the ?TGF&#946;1 system including latent binding proteins (LTBPs), local activators (Thrombospondin-1, matrix metalloproteases, integrins, among others), and TGF&#946; receptors. Pituitary TGF&#946;1 activity and the expression of different components of the TGF&#946;1 system, are regulated by dopamine and estradiol. Prolactinomas (animal models and humans) present reduced TGF&#946;1 activity as well as reduced expression of several components of the TGF&#946;1 system. Therefore, restoration of TGF&#946;1 inhibitory activity represents a novel therapeutic approach to bypass dopamine action in DARPs. The aim of this review is to summarize the large literature supporting TGF&#946;1 important role as a local modulator of pituitary lactotroph function; as well to provide recent evidence of the restoration of TGF&#946;1 activity as an effective treatment in experimental prolactinomas.","palabras_clave":"TGFb1|Dopamina|estradiol|prolactinoma"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":348,"idioma_id":5,"titulo":"Las ideas sobre el buen comienzo y la primera infancia: construcciones hegemónicas y apropiaciones locales","resumen":"En los últimos años, dentro y fuera de nuestro país, tiene lugar un progresivo desarrollo de propuestas destinadas a la Primera Infancia. Con este desarrollo, un enunciado que se ha ido instalando con fuerza es el relativo al buen comienzo. En este artículo el objetivo es analizar los sentidos hegemónicos y las apropiaciones locales que se construyen en documentos y programas de intervención.en torno a dicho enunciado.  Es nuestra hipótesis que las postulaciones contemporáneas sobre el buen comienzo reordenan ?con continuidades y transformaciones- sentidos relativos al desarrollo, la socialización y el papel de las familias en el cuidado infantil. Aludimos a sentidos que son recuperados activamente en los contextos cotidianos en donde tienen lugar las iniciativas. Para este análisis nos basaremos en los registros etnográficos realizados en el trabajo antropológico que llevamos adelante en barrios populares del Gran Buenos Aires","palabras_clave":"PRIMERA INFANCIA|ORGANISMOS INTERNACIONALES|POLITICAS PUBLICAS|REGULACIONES FAMILIARES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":350,"idioma_id":4,"titulo":"Creativity, involvement and leisure time: The more, the better","resumen":"The study examined relationships between participation in leisure activities and creative potential, creative achievement, ideational behavior, and participants? self-assessment. Men and women (N = 659) living in Córdoba (Argentina) participated in the research. The sample represented socio-demographic diversity, including age, level of schooling, and occupation. Interesting correlations between leisure activities and the different assessments of creativity were observed. Involvement in leisure activities and self-assessment of creative potential seemed to be accurate indicators of creativity in everyday contexts. Interesting lines of intervention and future investigation emerged. These implications are presented, along with limitations to the research, at the end of the article.","palabras_clave":"CREATIVITY|LEISURE|TEST CREA|CREATIVE POTENCIAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":351,"idioma_id":5,"titulo":"Construcción y análisis de las propiedades psicométricas del Cuestionario de Acciones Creativas en población argentina","resumen":"El objetivo del estudio es construir un instrumento creado para evaluar acciones creativas en diferentes contextos y áreas de conocimiento, y analizar sus propiedades psicométricas. El Cuestionario de Acciones Creativas (CAC) se ha elaborado considerando perspectivas teóricas actuales referidas a la creatividad cotidiana e instrumentos validados en estudios anteriores. Se incorporaron dos áreas, creatividad cotidiana y participación social, que resultan novedosas respecto de los cuestionarios vigentes. Se presentan las tres etapas del estudio: construcción del instrumento, prueba piloto y estudio psicométrico de la versión definitiva. Además del CAC, se administró el Test CREA (Corbalán et al., 2003), Inventario Biográfico de Comportamiento Creativo (Batey, 2007) y un cuestionario general sobre tiempo libre. Participaron 904 personas adultas que viven en la provincia de Córdoba (Argentina). Los resultados muestran que la estructura factorial exploratoria del instrumento se adecua con las teorías de referencia. Los estudios han demostrado una adecuada  confiabilidad, y correlaciones elevadas entre el CAC y el Inventario Biográfico de Comportamiento Creativo. También se observaron diferencias significativas en el CAC entre dos grupos de contraste: personas que participan en actividades de ocio y personas que no participan. Se observaron diferencias en las mediciones según sexo, edad y nivel de escolaridad. Se destaca la importancia del instrumento en la investigación, evaluación y promoción de la creatividad cotidiana.","palabras_clave":"CREATIVIDAD COTIDIANA|OCIO|ACCIONES CREATIVAS|APERTURA A LA EXPERIENCIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":354,"idioma_id":5,"titulo":"Etapas de crecimiento urbano de El Calafate, provincia de Santa Cruz, Patagonia austral andina argentina (1927 - 2010)","resumen":"El Calafate localizada al Sudoeste de la Provincia de Santa Cruz, desde sufundación, 1927, hasta 1980 la actividad económica predominante fue la deservicios de la explotación ganadera. Desde 1980, es reemplazada por laturística, actividad que atrajo y atrae desplazamientos migratorios con distintos ritmos, que han incidido en el crecimiento demográfico y urbano.De este modo, el objetivo del trabajo es estudiar el crecimiento urbano de ElCalafate desde 1927 hasta 2010, a partir del análisis y correlación de hechoshistóricos, económicos, políticos, entre otros para determinar cortestemporales.Metodológicamente se analizó historia y economía por medio de bibliografíacientífica y fuentes secundarias; crecimiento demográfico con datosestadísticos; se elaboró cartografía temática a través de un SIG por medio delectura de cartografía histórica y actual.Se obtuvieron características históricas, demográficas, económicas cuyasvariables se relacionaron y posibilitaron determinar los cortes temporales.","palabras_clave":"El Calafate|Patagonia Austral Andina Argentina|Etapas de crecimiento urbano|Turismo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":355,"idioma_id":4,"titulo":"Selective neuronal degeneration in the retrosplenial cortex impairs the recall of contextual fear memory","resumen":"The retrosplenial cortex (RSC) is one of thelargest cortical areas in rodents, and is subdivided in twomain regions, A29 and A30, according to their cytoarchitecturalorganization and connectivities. However, verylittle is known about the functional activity of each RSCsubdivision during the execution of complex cognitivetasks. Here, we used a well-established fear learning protocolthat induced long-lasting contextual fear memory andshowed that during evocation of the fear memory, the expressionof early growth response gene 1 was up-regulatedin A30, and in other brain areas implicated in fear andspatial memory, however, was down-regulated in A29,including layers IV and V. To search for the participationof A29 on fear memory, we triggered selective degenerationof neurons within cortical layers IV and V of A29by using a non-invasive protocol that takes advantage ofthe vulnerability that these neurons have MK801-toxicityand the modulation of this neurodegeneration by testosterone.Application of 5 mg\/kg MK801 in intact malesinduced negligible neuronal degeneration of A29 neuronsand had no impact on fear memory retrieval. However, inorchiectomized rats, 5 mg\/kg MK801 induced overt degenerationof layers IV?V neurons of A29, significantlyimpairing fear memory recall. Degeneration of A29 neuronsdid not affect exploratory or anxiety-related behaviornor altered unconditioned freezing. Importantly, protectingA29 neurons from MK801-toxicity by testosterone preservedfear memory recall in orchiectomized rats. Thus,neurons within cortical layers IV?V of A29 are criticallyrequired for efficient retrieval of contextual fear memory.","palabras_clave":"Retrosplenial cortex (RSC)|Contextual fear memory - Memory retrieval|Zif268 - Dizocilpine|Neurodegeneration"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":356,"idioma_id":4,"titulo":"A generalization of a result of Dong and Santos-Sturmfels on the Alexander dual of spheres and balls","resumen":"We prove a generalization of a result of Dong and Santos?Sturmfels about the homotopy type of the Alexander dual of balls and spheres. Our results involve NH-manifolds, which were recently introduced as the non-pure counterpart of classical polyhedral manifolds. We show that the Alexander dual of an NH-ball is contractible and the Alexander dual of an NH-sphere is homotopy equivalent to a sphere. We also prove that NH-balls and NH-spheres arise naturally when considering the double duals of standard balls and spheres.","palabras_clave":"Alexander dual|Simplicial ball|Simplicial sphere"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":357,"idioma_id":4,"titulo":"A habitat suitability model for capybara (Hydrochoerus hydrochaeris) at its core area in Argentina","resumen":"Habitat loss is one of the main factors reducing wildlife diversity and restricting its conservation. Habitat suitability models are importanttools for wildlife management and conservation in order to evaluate the impacts of human activities on wildlife habitats. The capybara(Hydrochoerus hydrochaeris) is a semi-aquatic rodent that lives in South American wetlands that are subject to heavy human use. A spatiallyexplicit model of capybara´s Potential Habitat Suitability (PHS) was developed for the core area of its distribution in the humid subtropicalregion of Argentina. Predictive variables in this deductive model were related to capybara habitat requirements, and their values wereobtained from existing published papers. The PHS model was performed using two data subsets that evaluated both ecological requirementsand anthropogenic threats, resulting in two partial indices: Potential Ecological Suitability (PES), and Risk of Human Impact (RHI). The PESassesses vegetation cover and the presence of lentic and lotic freshwater bodies. The RHI estimates habitat fragmentation and accessibilityof poachers. Variables for the habitat requirements were spatially expressed through Geographic Information Systems. The model accuracyassessment was performed through field work and achieved 72% of overall accuracy. Results indicate that 13% of the study area had thehighest values of PHS index, characterized by the presence of vast wetlands, habitats with low fragmentation and low accessibility forpoachers. These results are a useful tool to improve conservation and management programs for protection of capybara habitat.","palabras_clave":"capybara|SIG|wildlife|deductive model"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":359,"idioma_id":4,"titulo":"Evidence of the occurrence of structural chromosome changes at the initial diploid diversification of the autopolyploid Turnera sidoides L. (Passifloraceae) complex","resumen":"Turnera sidoides is an autopolyploid complex of obligate outcrossing perennial herbs. It includes five subspecies and five morphotypes in which diploid to octoploid cytotypes were found. Based on phenetic analyses of the complex and karyotype data of polyploid cytotypes, it has been hypothesized that morphological and chromosome differentiation of T. sidoides occurred at diploid level. To test this hypothesis, we present the first detailed chromosome analysis of diploid populations of three subspecies and four morphotypes. CMA+\/DAPI- bands were restricted to secondary constrictions (except in the andino morphotype), and varied in number and position among taxa. By contrast, DAPI staining was uniform in all the materials investigated. The number and position of 45S rDNA loci were coincident with the CMA+\/DAPI- bands associated with secondary constrictions. Only one pair of 5S rDNA loci was detected in all the taxa (except in subsp. holosericea), but in variable position. The identified chromosome markers, varied among the three subspecies analyzed, but they were more conserved among the morphotypes of subspecies pinnatifida. The cluster analysis of these chromosome markers supports the current taxonomic arrangement of diploids and demonstrates that structural chromosome changes would have led or accompanied the initial differentiation of T. sidoides at diploid level.","palabras_clave":"TURNERA SIDOIDES|DIPLOID|CHROMOSOME DIFFERENTIATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":361,"idioma_id":4,"titulo":"Continuous white-blue led light exposition delays postharvest senescence of broccoli","resumen":"In this work, the impact of low intensity (20 &#956;mol m-2 s-1) continue illumination with white and blue light-emitting diodes (WB LED) on the shelf life of broccoli heads stored at 5 °C or at 22 °C was assessed. At both temperatures, heads stored under WB LED showed the highest levels of chlorophylls, reflected in a higher Hue angle and lower L* values compared to controls stored in the darkness. Also, during storage at 22 °C the treated samples had a slower rate of sugar lost compared to dark stored controls. At 5 °C, glucose and fructose levels were maintained and sucrose was increased by the WB LED treatment. The dark stored controls showed the highest accumulation of antioxidant compounds, but there were no differences in ascorbic acid content except for the last storage day at 5 °C, being the WB LED samples which had a slightly higher level (p in the total carotenoid content, mainly during storage at 22 °C. According to the results, WB LED treatment would be a feasible and low cost technology to enlarge the postharvest storage of whole broccoliheads.","palabras_clave":"LED|antioxidants|illumination|quality"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":362,"idioma_id":5,"titulo":"Secundarias Rurales Mediadas por Tics en el Norte de Argentina: Democratización, Inclusión Y Problemas Éticos","resumen":"Desde 2006 enArgentina, la educación secundaria es obligatoria. Esto accionó medidasestructurales y coyunturales que incorporan de forma estratégica a las nuevastecnologías desde lo pedagógico, como herramienta para la mejora de la gestióneducativa. No obstante, en zonas rurales este proceso presenta dificultades. Anteeste escenario, realizamos una investigación descriptiva interpretativa en Salta,provincia fronteriza del norte argentino, sobre una original experiencia deeducación secundaria rural mediada por TIC. El objetivo del estudio fue reconocerdesde las voces de los docentes el estado de desarrollo de la propuesta,dificultades y potencialidades. Realizamos un trabajo de indagacióncualitativa, entrevistas y análisis de documental, que permitió significar yproblematizar desde una concepción crítica el impacto de esta estrategia,resaltando los sentidos emergentes dan cuenta de tensiones éticas y pedagógicasque se revelan en la puesta en marcha del proyecto, sus avances formales y lacontinuidad de postergaciones socio-educativas históricas.","palabras_clave":"COBERTURA|SECUNDARIA|VIRTUAL|RURAL|INCLUSION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":363,"idioma_id":4,"titulo":"Contributions on the spider families Nesticidae and Pholcidae (Araneae) from Argentina","resumen":"A new species of Nesticus Thorell, 1869, N. salta sp. nov., and a new species of Guaranita Huber, 2000, G. dobby sp. nov., are described from the Chaco Serrano ecoregion of Salta Province (Argentina). The female of G. yaculica Huber, 2000 is described for the first time, and the known distribution of G. munda (Gertsch, 1982) is enlarged to Jujuy Province, northern Argentina.","palabras_clave":"Spiders|Nesticus|Guaranita|New species|New record"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":364,"idioma_id":4,"titulo":"Correlation between functional and ultrastructural substrate In Brugada Syndrome.","resumen":"Brugada syndrome (BS) was reported for the first time in 1992, and is associated with a ST segment elevation in the right precordial leads in the absence of any demonstrable structural heart disease, as well as sudden cardiac death due to ventricular fibrillation (VF) 1. Type 1 electrocardiogram (ECG) patent is diagnostic of BS and is characterized by a coved ST&#8208;segment elevation &#8805; 2 mm followed by a negative T wave in > 1 right precordial lead (V1 to V3) in the presence or absence of a sodium channel? blocking agent, and in conjunction with one of the following: documented VF, polymorphic ventricular tachycardia (VT), a family history of sudden cardiac death at <45 years old, coved&#8208;type ECGs in family members, inducibility of VT\/VF with programmed electrical stimulation, syncope, or nocturnal agonal respiration2. An autosomal dominant disease with incomplete penetrance, BS has been linked to mutations in SCN5A, the gene encoding the alpha subunit of the cardiac sodium channel. Still, SCN5A mutations have been reported in only &#8776;20% of patients with Brugada syndrome diagnosed on the basis of clinical criteria, suggesting that other genetic defects and\/or other disease mechanisms may give rise to this clinical picture.","palabras_clave":"Brugada syndrome |heart disease|ventricular fibrillation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":365,"idioma_id":4,"titulo":"Batch leaching tests of motherboards to assess environmental contamination by bromine, platinum group elements and other selected heavy metals","resumen":"In this study, a batch leaching test was executed to evaluate the toxicity associated with chemicals contained in motherboards. The leaching solutions used were distilled water, nitric acid, acetic acid and synthetic acid rain solution. A total of 21 elements including Ag, As, Au, Br, Cd, Co, Cr, Cu, Hf, Ir, Mn, Ni, Os, Pb, Pd, Pt, Rd, Rh, Se, U and Zn were analyzed. In this study, the pH values of all the leachates fell within the range of 2.33?4.88. The highest concentrations of metals were obtained from the acid rain solution, whilst the maximum value of bromine was achieved with solution of acetic acid. Appreciable concentrations of platinum group elements were detected with concentrations around 3.45, 1.43, 1.21 and 22.19 µg L&#8722;1 for Ir, Pd, Pt and Rh, respectively. The different leaching of the motherboards revealed the predominant presence of the toxic substances in the leached from the e-waste.","palabras_clave":"Electronic waste|Bromine|Platinum group elements|Heavy metals|Batch leaching tests|ICP-MS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":366,"idioma_id":5,"titulo":"Jujuy en el espacio peruano. Una aproximación desde la teoría del lugar central","resumen":"Este trabajo pretende constituir una aproximación a la caracterización económica de Jujuy en el período fundacional y temprano colonial y su relación con el espacio económico en el cual estaba inserto, dominado por el polo minero potosino y controlado política y administrativamente desde La Plata y Lima. Para ello recurrimos al modelo interpretativo propuesto por C. S. Assadourian, el más completo y ajustado destinado a describir el funcionamiento de Potosí y su hinterland; y también a fin de describir y explicar la dinámica de los nacientes núcleos urbanos y productivos, al modelo del Lugar Central, elaborado originalmente por W. C. Christaller y reconsiderado para la descripción regional por diversos autores posteriores, entre ellos Lösch y Richardson. Por su potencialidad descriptiva y por las características del espacio económico de referencia, este modelo resulta ser apropiado a los fines de tal comparación; siendo algunos de sus elementos, útiles para describir y explicar parte de la compleja dinámica que adquirió Jujuy en el sistema económico colonial","palabras_clave":"historia colonial|urbanizacion|Jujuy|modelos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":367,"idioma_id":5,"titulo":"El valor del atributo ?sustentable? para la Generación Y en las elecciones de compra.","resumen":"El objetivo del trabajo es valorar las elecciones efectivas que hacen los consumidores frente a diferentes alternativas de consumo de productos y servicios donde están presentes atributos ?sustentables? (etiquetas ecológicas y sociales).Sabemos que el etiquetado es ampliamente considerado como la mejor herramienta para ofrecer a los consumidores información sobre los atributos sociales y ambientales (De Pelsmacker et al., 2005), La Organización Internacional de Normalización (ISO) clasifica las etiquetas en tres tipos (Carrero Bosch et al., 2010): El Tipo I son etiquetas basadas en un proceso auditado por un tercero (por ejemplo, la Eco-label). El Tipo II son auto-declaraciones, es decir, afirmaciones generales que aparecen en un escrito o simbólico (pictórica), no respaldadas por un tercero (por ejemplo, la utilización de frases como ?Amigos del medio ambiente?).  El Tipo III son etiquetas basadas en el desempeño (por ejemplo, el Comercio Justo - FairTrade).Se efectúo un trabajo cuantitativo exploratorio sobre una muestra de 160 participantes, del universo de estudio definido como la Generación Y, que es la generación joven que puede tener mayor conciencia ecológica y sostenible, aquella cohorte cuyas fechas de nacimiento está comprendida entre los años 1980 y 1994, y que en la Argentina, representa el 22 por ciento de la población.Las categorías (y subcategorías) estudiadas como los conceptos ?responsables? evaluados fueron definidos con un grupo de expertos y testeado con consumidores. Estos son: a) Electrodomésticos con eficiencia energética (televisores) b) Alimentos de comercio justo (Café) c) Cosmética no testea en animales (cremas faciales) y envases recargables (desodorante) d) Indumentaria elaborado con materiales orgánicos (camisas y sweater) e) Útiles escolares con sello FSC (lápices) y material reciclable (cuadernos) f) Juguetes a base de material reciclable (bloques para niños y muñecas para niñas), f) Hotelería con servicio de restaurant orgánico y cabañas con energía renovable y g) Productos de tecnología a base de material reciclable (celulares y\/o tablet). Los resultados muestran que detrás de la marca y del precio, el peso del atributo ecológico es altamente importante en categorías como electrodomésticos (ahorro de energía), alimentos (pack reciclables o reutilizables), lápices escolares y menos importante en categoría como juguetes, hotelería y electrónica donde aparecen otros atributos más relevantes como el diseño, la ubicación, el tamaño. Se muestran diferencias en la valoración de los atributos verdes en perfiles de consumidores responsables respecto de otros perfiles.","palabras_clave":"ETIQUETAS SOCIALES|MARCAS SUSTENTABLES|CONSUMO RESPONSABLE|CHOICE MODELING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":368,"idioma_id":5,"titulo":"A contrapelo de los montajes políticos y culturales de la figura de Señora. Cuestión testimonial y lugares de la  memoria en el cine de María Luisa Bemberg","resumen":"Testimonio se dice de muchas maneras y el relato cinematográfico es una de ellas. Tanto el cine documental como el 'de autor(a)' han sabido hacer suya la cuestión testimonial. Ambos han sido ocasión de relatos-otros que corroen las historias oficiales, testimoniando sus violencias, o que escapan al mercado del espectáculo. Éstos abren lugar para una historia singular que va a contrapelo de las ficciones estereotipadas por las determinaciones políticas y los ?pactos? culturales. El cine 'de autor(a)', que es objeto del presente trabajo, no sólo sortea los imperativos comerciales sino que toca los bordes de la autobiografía y es, sin duda, testimonio de una generación de mujeres. Como es bien sabido ya, los relatos testimoniales no son una simple narrativa que concurre a aportar información sobre los acontecimientos del pasado. Ellos son, por el contrario, efecto de un encuentro, en un diálogo y en un contexto de escucha disponible. El trabajo explora entonces los mencionados tópicos mediante un análisis de la obra temprana de María Luisa Bemberg plasmada en las películas Crónica de una señora- Momentos- señora de nadie.","palabras_clave":"Cuestión testimonial|Cine de autor(a)|Figura de Señora|María Luisa Bemberg"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":369,"idioma_id":5,"titulo":"AGENCIA Y VISUALIDAD: LAS IMÁGENES DE LA GUERRA DEL PARAGUAY. DE CÁNDIDO LÓPEZ A LOS VIDEOJUEGOS","resumen":"El objetivo de este trabajo es reflexionar sobre el rol y circulación de la imagen en las representaciones contemporáneas  sobre la Guerra del Paraguay y su resignificación, en particular el poder de agenciamiento de las obras de Cándido López y del propio artista en audiovisuales de la última década. Asimismo, analizar qué ocurre con esta visualidad al tratar el terreno de la imagen digital producto de la producción de videojuegos que han salido al mercado, o han sido creados por fans: es decir, qué ocurre con ese empoderamiento de las imágenes cuando éstas entran en el campo de la virtualidad y de la interactividad, y por lo tanto qué ocurre con los espectadores en este proceso.Partiendo de la producción de Cándido López, se analiza la agencia de la obra y del mismo artista en producciones audiovisuales argentinas como la serie documental 'Guerra Guasú', el documental 'Cándido López, los campos de batalla' y el capítulo sobre la Guerra del Paraguay en la serie 'Algo habrán hecho'. Asimismo, se indaga en el poder de apropiación y agenciamiento de estas imágenes y los nuevos escenarios y conflictos que se derivan en los videojuegos Triple Alliance War (serie Strategy & Tactics) y War of the Triple Alliance (WOTTA), modificación no comercial realizada por fans del videojuego de tiempo real Age of Empires III.","palabras_clave":"Guerra de la Triple Alianza|Candido Lopez|audiovisuales argentinos|videojuegos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":372,"idioma_id":4,"titulo":"Lake-level variations and tides in Lago Argentino, Patagonia: insights from pressure tide gauge records","resumen":"Based on precise pressure tide gauge observations lake-level records are derived for two sites in Lago Argentino, southern Patagonia, of 2.5 and 1 years of duration. Applying the tools of time series analysis, the principal processes affecting the lake level are identified and quantified. Lake-level changes reflecting variations in lake volume are dominated by a seasonal cycle of 1.2 m in amplitude. Lake-volume changes occur in addition with a daily period in response to melt water influx from surrounding glaciers. Sporadic lake-volume jumps are caused by bursting of the ice dam of Perito Moreno glacier. Water movements in Lago Argentino are dominated by surface seiches reaching 20 cm in amplitude. Lake tides reach a maximum amplitude of 3 mm. The comparison of the tidal signal extracted from the lake-level observations with a model composed of the contributions of body tide and ocean tidal loading indicates a phase shift of 23° which is most likely explained by an 1 hour phase lag of global ocean tide models in the region of the highly fragmented Pacific coast. The comparison of the obtained results with those of a previous study of Lago Fagnano, Tierra del Fuego, allows to relate differences in the hydrological and hydrodynamic processes between both lakes to morphological properties. This leads to a tentative prediction of the lake-level variability to be expected from other great Patagonian lakes. The presented geodetic results shall serve as a starting point for a detailed limnological investigation of these aquatic ecosystems.","palabras_clave":"hydrodynamics|lake level|surface seiches|tide gauge|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":373,"idioma_id":5,"titulo":"?Las disputas por el desarrollo: narrativas y posicionamientos de los empresarios de la Unión Industrial Argentina en las coyunturas políticas del 2008?","resumen":"Resumen En el presente artículo se analizan  algunas dimensiones ligadas a la problemática del desarrollo que se han reactualizado en la  Argentina en el último lustro. En  lo particular se distinguen los  posicionamientos y narrativas adoptadas por sectores de la burguesía urbana representados en la Unión Industrial Argentina (UIA),  considerando   la fertilidad que contiene pensar la relación entre modelo de acumulación, perspectivas y procesos de desarrollo, matriz política nacional-popular en el milenio actual. En este marco no solamente se han vitalizado y revitalizado los sectores sindicales y del trabajo sino conjuntamente, se han incorporado en la interpelación discursiva y de práctica política  del gobierno los actores empresarios. Los posicionamientos y retóricas propiciados desde  UIA son  estudiados a partir de dos  coyunturas  políticas específicas, con fuertes relaciones entre sí: la crisis y conflicto entre los sectores rurales y el gobierno nacional en el 2008, la crisis internacional que afectó a la Argentina en ese mismo año.  Ambas  coyunturas nos permiten ilustrar la manera en que este agrupamiento invocado e integrado por el gobierno  en su visión productivista del desarrollo, se fue  posicionado ante el actor estatal y  en sus relaciones intra  burguesas respecto de  problemáticas  claves   que reenvían a cuestiones ligadas con la temática del desarrollo.","palabras_clave":"Burguesía|Actividades urbano industriales|Desarrollo|Unión Industrial Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":375,"idioma_id":4,"titulo":"Glycosomal Bromodomain Factor 1 from Trypanosoma cruzi enhances trypomastigotes cell infection and intracellular amastigotes growth","resumen":"Acetylation is a ubiquitous protein modification present in prokaryotic and eukaryotic cells that participates in the regulation of many cellular processes. The bromodomain is the only domain known to bind acetylated lysines. In the last years many bromodomain inhibitors have been developed in order to treat diseases caused by aberrant acetylation of lysine residues and have been tested as anti-parasitic drugs. Here, we report the first characterization of T. cruzi Bromodomain Factor 1. Tc BDF1 is expressed in all life cycle stages but it is developmentally regulated. It localizes in the glycosomes directed by a PTS2 sequence. The overexpression of Tc BDF1 wild type is detrimental for epimastigotes, but it enhances the infectivity rate of trypomastigotes and the replication of amastigotes. On the other hand, the overexpression of a mutated version of Tc BDF1 has no effect on epimastigotes, but it does negatively affect on trypomastigotes´ infection and amastigotes´ replication.","palabras_clave":"Trypanosoma cruzi|Acetylation|Bromodomain|Metabolism"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":377,"idioma_id":5,"titulo":"Tiempo eléctrico en la Argentina del siglo XIX.Científicos, técnicos y estadistas cableando la unificación territorial","resumen":"Hacia fines del siglo XIX, en la Argentina, diversas disposiciones legales apuntaban a unificar la hora nacional. La idea era lograr la coordinación mediante señales telegráficas. Los intentos de medir el tiempo y sincronizar las horas locales adecuadamente se basaban en la necesidad de ensamblar  actividades distantes en lo que se empezaba a considerar como un territorio unificado.  El director del Observatorio de Córdoba y el de La Plata participarían en las redes sociales de los que intentaban el ajuste. La institución cordobesa sería además la encargada de fijar cuál sería la hora unificada que correría por los cables. Pero antes que eso, la pregunta de este artículo, es cómo el conocimiento y las tecnologías del trabajo astronómico repercutían en las imágenes de los estadistas de las época - en este caso en los que manifestaban su voluntad de sincronización territorial- y, viceversa, cómo las amplias transformaciones sociales de la época impactaban en los objetivos que se ponían los directores de los observatorios en el desarrollo de sus actividades. La pregunta involucra a las tecnologías telegráficas y de relojería; a las transformaciones en el mundo del trabajo que hacían que sea una necesidad el control minucioso de los tiempos y ritmos laborales y  a los intentos de mapear los territorios nacionales, entre otras cuestiones.","palabras_clave":"ARGENTINA|SIGLO XIX|MEDICIONES|TIEMPO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":378,"idioma_id":5,"titulo":"Números que ordenaron y desordenaron a la sociedad argentina. Intentos de mediciones espacio-temporales en el siglo XIX.","resumen":"Acostumbrados, como estamos, a cuantificar la realidad para ordenarla, no nos preguntamos por el pasado de los instrumentos y conceptos con los que emprendemos estas acciones. Lo contrario ocurría en un tiempo remoto, cuando la obstinación por medir quería imponerse  a costumbres tranquilas que nunca habían necesitado cuantificarse. Los números tenían que ganarse un lugar que todavía no tenían. Lo extraño era entonces confiar en ellos. Además, una vez que se decidió hacerlo, o que las condiciones condujeron a ello, ocurrió algo que ni el antiguo temor podría haber advertido: de tanto y tanto medir se terminó desordenando la vida. En la Argentina del siglo XIX, en medio de ese descalabro, se ubica este dossier. Aquí apuntamos a que las maneras en que expresamos las cantidades debieron unificarse por medio de arduos esfuerzos y difíciles procesos materiales, que estuvieron ligados también a caprichos, azares, disputas y otras cuestiones que nada tenían de exactas o de numéricamente ponderables.","palabras_clave":"MEDICIONES|ARGENTINA|SIGLO XIX|HISTORIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":379,"idioma_id":4,"titulo":"Influence of the Ionic Strength in the Intrinsic Viscosity of Xanthan Gum. An Experimental Review","resumen":"This study involves the influence of ionic strength in intrinsic viscosity of xanthan gum. The best concentration of monovalent and bivalent cations chloride salts is evaluated. The salt concentration is 0.001 M for monovalent cations and 3 x 10-5 M for bivalent cations and the hydrodynamic radius is maximum for these concentrations. The minimal concentration is in the range of 0.01 to 0.1 M for different cations.","palabras_clave":"XANTHAN GUM|IONIC STRENGHT|INTRINSIC VISCOSITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":383,"idioma_id":4,"titulo":"QTLs  detection  and  mapping  for  yield-related  traits  in  globe  artichoke","resumen":"The genetic basis of yield-related traits in Cynara cardunculus L. was studied in a F1 population derived from an inter-botanical varietal cross between wild cardoon and ?Estrella del Sur FCA? globe artichoke. The aim of this work was identify and localize QTLs (Quantitative Trait Loci) associated with yield-related traits as a first step to marker-assisted selection. Sixty-eight polymorphic markers (SSR) were used to analyze the segregating population by ANOVA approach. A second analysis based in previous linkage maps of the species was conducted in two seasons by SIM (Simple Interval Mapping) procedure. A totalof 66 QTLs associated with seven morphological traits were detected and mapped  in the first evaluated season, of these 42 were validated among both seasons. All QTLs identified are major QTLs (explain >10% of phenotypic variation) and 27 of these are responsible for >20% of phenotypic variation. This work represents an initial platform for the dissection of a complex trait, such as yield in the species. Although the QTLs detected need to be more precisely mapped, they will be targets in breeding programs of globe artichoke to improve yield-related traits.","palabras_clave":"CYNARA CARDUNCULUS|MOLECULAR MARKERS|QUANTITATIVE TRAITS LOCI|LINKAGE MAP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":384,"idioma_id":4,"titulo":"Is ursodeoxycholic acid detrimental in obstructive cholestasis?: apropos a case of malignant biliary obstruction","resumen":"Ursodeoxycholic acid (UDCA) is the ?first choice?medication for most cholestatic hepatopathies, due to its capability tocounteract inflammation and bile-acid-induced liver damage, two common featuresin cholestasis. However, UDCA is usually contraindicated in obstructivecholestasis, due to the alleged risk of biliary integrity disruption due to itscholeretic effect. We report on an 83-year-old man with an unsuspectedmalignant biliary obstruction who received moderate doses of UDCA (8-12 mg\/kg\/day)for 5 weeks, because the preliminary evidence suggested he hadchemotherapy-induced cholestasis. Liver integrity was extensively protected byUDCA, as indicated by a marked decrease in serum liver enzymes, despite asteady increase in the levels of bilirubin and serum bile acids due to theobstructive process. In conclusion, this report shows, for the first time inhumans, that moderate UDCA doses can reduce liver injury associated with completebiliary obstruction. This may contribute to a better understanding of therisk-benefit ratio of the use of UDCA in obstructive cholangiopathies.","palabras_clave":"Colestasis obstructiva|Ácido ursodeosoxicólico|Hepatoprotección|Sales biliares"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":386,"idioma_id":4,"titulo":"Chronic lead poisoning magnifies bone detrimental effects in an ovariectomized rat model of postmenopausal osteoporosis","resumen":"Lead (Pb) is a persistent environmental contaminant that is mainly stored in bones being an importantsource of endogenous lead exposure during periods of increased bone resorption as occurs in menopause.As no evidence exists of which bone biomechanical properties are impaired in those elderly women whohad been exposed to Pb during their lifetime, the aim of the present study is to discern whether chroniclead poisoning magnifies the deterioration of bone biology that occurs in later stages of life. Weinvestigated the effect of Pb in the femora of ovariectomized (OVX) female Wistar rats who had beenintoxicated with 1000 ppm of Pb acetate in drinking water for 8 months. Structural properties weredetermined using a three-point bending mechanical test, and geometrical and material properties wereevaluated after obtaining the load\/deformation curve. Areal Bone Mineral Density (BMD) was estimatedusing a bone densitometer. Femoral histomorphometry was carried out on slices dyed with H&E(Hematoxylin and Eosin). Pb and OVX decreased all structural properties with a higher effect when bothtreatments were applied together. Medullar and cortical area of femurs under OVX increased, allowingthe bone to accommodate its architecture, which was not observed under Pb intoxication. Pb and OVXsignificantly decreased BMD, showing lead treated ovariectomized rats (PbOVX) animals the lowest BMDlevels. Trabecular bone volume per total volume (BV\/TV%) was decreased in OVX and PbOVX animals in54% compared to the control animals (p < 0.001). Pb femurs also showed 28% less trabeculae than thecontrol (p < 0.05). We demonstrated that Pb intoxication magnifies the impairment in bonebiomechanics of OVX rats with a consequent enhancement of the risk of fracture. These results enablethe discussion of the detrimental effects of lead intoxication in bone biology in elderly women.","palabras_clave":"PLOMO|OVARIECTOMIA|BIOMECANICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":387,"idioma_id":5,"titulo":"Estudios sobre la viabilidad de adsorción de arseniato mediante derivados de huesos y caracoles","resumen":"In this work feasibility of arsenic (As) removal from aqueous solutions employing low cost adsorbents was analyzed. 10 ppm As solutions were treated with 1 g of hydroxyapatite, three derivatives, nacre and external surface of shells, for 24h to ensure equilibrium. Hydroxyapatite showed the highest adsorption performance removing a 43% approximately.","palabras_clave":"Arsenic Removal|Hydroxyapatite"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":388,"idioma_id":4,"titulo":"Study of the chlorogenic acid content in yerba mate (Ilex paraguariensis St. Hil.): Effect of plant fraction, processing step and harvesting season.","resumen":"Chlorogenic acid (CGA) is a fine chemical used in different food and pharmaceutical industries. CGA is currently extracted from various plant materials, particularly green coffee beans. Yerba mate (Ilex paraguariensis St. Hil.) contains significant amounts of CGA with very low levels of extraction interfering substances (fatty materials). Both of these reasons prompted us to evaluate yerba mate as a novel source for extraction of this compound.CGA content was quantified in various yerba mate fractions during different processing steps, and in samples taken from two companies at early and late harvesting seasons. Samples were exhaustively extracted with hot water and total CGA content (including its three isomeric compounds) was determined by HPLC. Total CGA content (on a dry weight basis) ranged from 45.8 ± 0.4 to 80.8 ± 1.0 g CGA kg-1 of leaves and from 31.6 ± 0.6 to 78.9 ± 5.3 g CGA kg-1 of stems. A substantial reduction in CGA content was found along the processing steps. The highest CGA content was found in samples from freshly harvested (green) yerba mate, for both leaves and stems; with no significant differences in their CGA content (P < 0.05). CGA content at the early harvesting season was substantially higher to that obtained at the end of the harvesting season, for both green leaves and stems.Green stems, a residue from yerba mate processing obtained at the early harvesting season, could be considered as a promising and valuable raw material for the production of CGA-enriched extracts.","palabras_clave":"CHLOROGENIC ACID|ILEX PARAGUARIENSIS|YERBA MATE|SOLID-LIQUID EXTRACTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":392,"idioma_id":5,"titulo":"?Todos los caminos conducen a la militarización del territorio??. La idea de Nación y la apropiación de la tierra en la prensa patagónica (1921-1944).","resumen":"    Nos proponemos abordar la construcción discursiva que reflejaba la  prensa regional vinculada a la asociación entre la idea de nación y la  apropiación del territorio en los límites comprendidos por lo que se  constituirá entre 1944-1955 en Gobernación Militar de Comodoro Rivadavia.  Buscamos analizar de qué modo los grupos económicos representados en las  opiniones vertidas en la Revista Argentina Austral y el Diario El Chubut,  reflejan una serie de intereses asociados a la defensa del territorio en  términos nacionalistas y la necesidad de explotación económica que demandaba la  inserción de las tierras patagónicas al contexto nacional e internacional. La  connotación militar que tendrán estos reclamos condujeron a otorgar legitimidad  a la militarización del territorio bajo la órbita de la Gobernación Militar. En  este sentido, la prensa ocupará un lugar trascendental tanto a través del  contenido escrito de sus notas periodísticas, como visuales, que serán  analizadas en nuestro artículo. En particular nos abocaremos al análisis del  debate en torno al ?reparto de las tierras públicas? que ocupaba gran parte de  las notas de prensa de las fuentes señaladas.    &nbsp;    &nbsp;    &nbsp;          ","palabras_clave":"tierra pública|patagonia|rural|grupos dominantes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":393,"idioma_id":4,"titulo":"Electronic properties of Cantor random box distribution of impurities in graphene","resumen":"The aim of this work is to study the electronic properties of graphene under random impurities which are distributed in the energy line following the Cantor set box distribution. This implies that for each iteration k, the possible energy values of the random impurities lie in the line segment of the Cantor set in the interval (a\/2,a\/2). By applying the full T-matrix approximation, the electronic density of states is obtained for each iteration k and the limit k -> infinity limit is taken. A metal-insulator transition is obtained for critical values of a, where a resonance peak in the DOS at the Fermi level is split in two bands that shift towards the band edges when the width a increases. In turn, the electronic density of states for k>2 only enhance the van Hove singularities, resonant and antiresonant states for k = 2. In the other side, the Cantor set signatures are shown through a spectrum rearrangement for different values of a, where resonant states split in two narrow peaks for k = infinity. These results are important to study the transport properties in graphene with doped-based fractal superlattices, magnetic or electric barriers or multilayers with triadic patterns.","palabras_clave":"GRAPHENE|IMPURITIES|ELECTRONIC PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":394,"idioma_id":5,"titulo":"Adhesión entre polímeros dentales, influencia de sus componentes y  sistemas de polimerización.","resumen":"Muchos trabajos científicos hacen incapié en el estudio de la unión desos sistemas de fijación a los tejidos dentarios, creemos que se debe estudiar a lossistemas adhesivos basando sus uniones a dentina y esmalte pero sabemos que debeanalizarse el comportamiento con todos los sustratos intervinientes, es por lo que esnecesario la observación de la unión con el material restaurador o medio de cementadomediante la capa inhibida que forma el adhesivo dentinario. Se confeccionaron dos grupos1- Resina fluídahidrofóbica 2- Adhesivo monocomponentehidrofóbico e hidrofílico. mSeanalizaron cinco muestras para cada grupo. Las muestras se confeccionaron basándose enla norma IRAM 27 experimento 6-7 espesor de película no curada.El principio se basa en ladiferencia en los índices de refracción de monómeros curados y no curados, al ser diferentes se puede determinar las diversas zonas y así medir la parte no polimerizada,capa inhibida. Las mediciones se realizaron con microscopía óptica y la valoración con unacámara de Neubauer. Los resultados mostraron capas inhibidas de mayor espesor y másregulares para aquellos adhesivos puramente hidrofóbicos, las mezclas de hidrofóbicos ehidrofílicos mostraron capas muy irregulares y de menor espesor.","palabras_clave":"Adhesivo|Hidrofobica|Hidrofilica|Capa inhibida"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":395,"idioma_id":4,"titulo":"Lysophosphatidylcholine Drives Neuroblast Cell Fate","resumen":"Abstract Neuronal differentiation plays a key role during embryogenesis. However, based on the capacity of neuronal stemcellstoeithergenerateorregenerateneuronsandbecause differentiation stops aberrant neuroblasts proliferation, neuronal differentiation is crucial during neuropathological conditions. Although phosphatidylcholine (PtdCho) has been proposed asanimportant moleculefor neurite growthand neuronal regeneration, the identity of the molecular target has remained elusive. This study originally describes that lysophosphatidylcholine (LPtdCho), either exogenously supplied or generated by the imbalance of PtdCho metabolism through the enzymatic action of cytosolic phospholipase A2, acts as a neurotrophic-like factor. We demonstrated that LPtdCho induces neuronal differentiation by activation of the small G protein Ras followed by the Raf\/MEK\/ERK signaling pathway. Accordingly, LPtdCho redirects neuroblasts geneexpressionleadingtothegenerationoffunctionalmature neurons expressing &#946;III-tubulin and having increased acetylcholinesterase activity and membrane biosynthesis required for neuritogenesis.Thesefindingsprovidemechanisticdetails oftheroleofcytidine-5-diphosphocholine(CDP-choline)and PtdCho as neuroprotectors. Furthermore, as LPtdCho recapitulates the effect of the therapeutic agent retinoic acid, these","palabras_clave":"Phosphatidylcholine|Neurons|Differentiation|Lipid Signaling"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":396,"idioma_id":5,"titulo":"¿Qué hay de nuevo en el sindicalismo argentino? Relaciones laborales y reconfiguración sindical en el kirchnerismo.","resumen":"El proceso de gobierno de la última década  tuvo como elemento central la superación de la crisis más importante que atravesó Argentina donde la dinámica económica posibilitó la creación de empleo y la superación de los altos niveles de desempleo, que acompañaron el desarrollo argentino desde mediados de la década del 90. La recuperación de los niveles de empleo, la vitalidad de la negociación colectiva y el incremento de la conflictividad laboral volvieron a colocar al actor sindical en el centro de la escena política. En el presente artículo analizamos la dinámica sindical en Argentina en la última década desde tres dimensiones de su práctica institucional. Luego de plantear una descripción analítica del proceso económico de contexto y su impacto en el mundo del trabajo, abordamos las lógicas predominantes de la negociación colectiva en el período, las estrategias de alianzas y conflictos desplegados por las centrales sindicales y el desarrollo de la representación en los espacios de trabajo. Las dos primeras apuntan a un enfoque centrado en las políticas de las dirigencias de las organizaciones, la tercera intenta adentrarse en la dinámica política interna de los sindicatos poniendo la mirada en las bases sindicales.","palabras_clave":"RELACIONES LABORALES|SINDICATOS|KIRCHERISMO|CONFLICTO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":398,"idioma_id":4,"titulo":"Drivers of phytoplankton diversity in Patagonian and Antarctic lakes across a latitudinal gradient (2150 km): the importance of spatial and environmental factors","resumen":"We investigated the phytoplankton struc- ture in 60 lakes across a latitudinal gradient (2150 km), from Austral Patagonia to Antarctica, including envi- ronments ranging from oligotrophic to eutrophic. We analysed the latitudinal variation of species richness (local and regional) and evenness, as well as the similarity decay in phytoplankton composition in Patagonia and Antarctica. The following hypotheses were tested: (1) there is a decline of phytoplankton species richness with increasing latitude; (2) phyto- plankton structure is influenced by both geographical and environmental factors. (3) The predominant alga trophic strategy (autotrophic vs mixotrophic) is influ- enced by lake trophic status. Phytoplankton was analysed using a polyphasic approach (morphological- ly based species diversity, functional diversity, dominant molecular diversity). We found a significant decline in phytoplankton richness with increasing latitude. Multivariate analyses showed that phyto- plankton is structured by the lake geographic position (mainly latitude) and variables related with trophic state (nutrients, conductivity and pH). The autotrophs\/ mixotrophs ratio increased towards higher trophic states. The initial similarity was higher in Antarctica than in Patagonia, whereas the halving distance was lower for Antarctic lakes. The three biodiversity approaches of this meta-analysis evidenced that both geographic and environmental factors influence phy- toplankton diversity at large spatial scale, although the local effect was stronger.","palabras_clave":"PHYTOPLANKTON|LAKES|LATITUDINAL GRADIENT|DIVERSITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":399,"idioma_id":5,"titulo":"Zooarqueología de un centro administrativo Inka del Valle de Yocavil (Catamarca): el Tambo de Punta de Balasto, Grupo Arquitectónico 7","resumen":"En este trabajo se presentan los resultados del análisis de la arqueofauna del sitio Inka ?Tambo de Punta de Balasto?, localizado al sur del valle de Yocavil o Santa María (Catamarca, Argentina). Punta de Balasto es un centro imperial, entre cuyas funciones debió estar la administración político-económica del territorio y el albergue de autoridades y trabajadores al servicio del estado. El conjunto proviene de un basural en las inmediaciones del Grupo Arquitectónico 7, una estructura del tipo cancha o RPC. Si bien se conocen otros materiales faunísticos del Período Inka del Noroeste Argentino, la mayoría proviene de sitios del Período Desarrollos Regionales que fueron afectados al Tawantinsuyu, mientras que Punta de Balasto fue construido y utilizado exclusivamente para fines de la administración imperial.","palabras_clave":"Yocavil|Período Inka|Tambo|Zooarqueología"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":400,"idioma_id":5,"titulo":"Mímesis, teatro y acción: acerca de cuánto de Aristóteles hay en el pensamiento político de Arendt","resumen":"La recuperación de Aristóteles en la obra de Arendt ha generado una serie de críticas a su pensamiento, basadas en la nostalgia por el pasado, la idealización de la política griega y los límites de la distinción poíesis-prâxis. Considero que la mirada arendtiana de la antigüedad griega y de los aportes aristotélicos al pensamiento político tiene la particular ventaja de poner en discusión la comprensión actual de ciertos comportamientos humanos y permite repensar sobre aquellos elementos que, en nuestra cultura, se hallan actualmente en crisis y socavan la propia condición humana. Desde esta perspectiva, en el presente artículo examinaré la reapropiación de la noción de mímesis de Aristóteles en la concepción arendtiana de acción política, tomando como eje la articulación que dicha noción promueve entre prâxis y poíesis.","palabras_clave":"MIMESIS|POIESIS|PRAXIS|TEATRO|POLÍTICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":401,"idioma_id":4,"titulo":"Milk fatty acid profile from grazing buffaloes fed a blend of soybean and linseed oils","resumen":"The aim of the study was to examine the changes in milk fatty acid (FA) profile of grazing buffaloes fed either low (L, 276g\/d) or high (H, 572g\/d) doses of a blend (70:30, wt\/wt) of soybean and linseed oils.  Fourteen multiparous Mediterranean buffaloes grazing on a native pasture were fed 4 kg\/day of a commercial concentrate containing no supplemental oil over a pre-experimental period of ten days. The baseline milk production and composition and m i l k FA profile were measured over the last three days. After this pre-experimental period the animals received the same concentrate added with either the L or H oil doses for 26 additional days. Milk yield (g\/animal\/day) did not differ at the start (1776 ± 522 and 1662 ± 291 for L and H, respectively, P<0.622) or at the end of the t r i a l (4590 ± 991 and 4847 ± 447 in L and H, respectively, P<0.543). Baseline milk fat content (g\/kg) averaged 77.1 (±20.5) in L and 74.3 (±9.9) in H  (P<0.10) and was reduced (P<0.031) to 60.7 (±23.6) and 49.4 (±11.2) (P<0.0031) respectively after L and  H with no differences between treatments (P<0.277). Baseline milk protein content (L=43.2 ± 3.4 and H=  44.3 ± 6.9g\/kg) increased after oil supplementation (P<0.0001) in both L (73.2 ± 6.0g\/kg) and H (68.4 ± 4.9g\/kg) without differences between oil doses (P<0.123). Milk fat content of 14:0 decreased after oil  supplementation only in the H treatment (5.29 to 4.03, P<0.007) whereas that of 16:0 was reduced (P<0.001) at both L (24.49 to 19.75g\/100g FA) and H (25.92 to 19.17g\/100g FA) doses. The reduction of total content  o f 12:0 to 16:0 was higher (P<0.052) in H (32.02 to 23.93g\/100g FA) than L (30.17 to 25.45g\/100g FA). Vaccenic acid content increased (P<0.001) from 5.70 to 13.24g\/100g FA in L and from 5.25 to 16.77 in H,  with higher results in the in H treatment (P<0.001). Baseline rumenic acid was sharply increased (P<0.001) in L (1.80 to 4.09g\/100g FA, +127%) and H (1.60 to 4.61g\/100g FA, +187%) with no differences between  L and H (P<0.19). Overall, these results indicate a pronounced improvement in the nutritional value of milk fat from grazing buffaloes fed little amounts (0.276g\/day) of a blend of soybean and linseed oils.","palabras_clave":"Buffaloes|CLA|Milk|Soybean and linseed oil"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":402,"idioma_id":4,"titulo":"Effect of cryoprotectant and equilibration temperature on cryopreservation of Lama glama spermatozoa","resumen":"The aim of this study was to determine the effect of two equilibration temperatures  (5 °C and room temperature) and two cryoprotectants (glycerol and  dimethylformamide, both at 7%) on llama sperm cryopreservation. Llama ejaculates  were divided into four aliquots. A lactose-EDTA-egg yolk (LEEY) extender  with either 7% glycerol (LEEY-G) or 7% dimethylformamide (LEEY-DMF)  was added to two of the aliquots, which were equilibrated for 20 min at room  temperature and subsequently frozen. The other two aliquots were extended in  LEEY, cooled to 5 °C, then LEEY-G or LEEY-DMF was added, equilibrated for  20 min at 5 °C and frozen. No significant differences (P > 0.05) were observed  in membrane function and chromatin condensation between any of the freeze?  thawing protocols. Post-thaw motility was greater (P < 0.05) in LEEY-DMF  than LEEY-G. DNA fragmentation was not different between raw and frozen  semen with LEEY-DMF but was high in all samples with glycerol. Our results  indicate that 7% glycerol would be detrimental for llama spermatozoa, but further  studies are needed to evaluate effectiveness if used at lower concentrations.  Dimethylformamide preserved motility and DNA integrity of frozen?thawed  llama spermatozoa","palabras_clave":"CRYOPRESERVATION|DIMETHYLFORMAMIDE|GLYCEROL|LAMA GLAMA SEMEN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":404,"idioma_id":4,"titulo":"Temporal and spatial differences in the reproductive biology of the sea urchin Arbacia dufresnii","resumen":"The reproductive cycle of Arbacia dufresnii was studied in two contrasting populations on the east coast of Patagonia (Nuevo Gulf and San Jorge Gulf) from January 2008 to August 2010. Sea urchins from San Jorge Gulf had larger test diameter and heavier gonads than sea urchins from Nuevo Gulf. Arbacia dufresnii showed an annual cycle in both populations, with gametogenesis occurring mainly in the autumn and the winter. An extended spawning period took place during the spring and the summer. Sea urchins from Nuevo Gulf had a strong seasonal pattern of reproduction, with presence of gonadal stages showing reabsortion and accumulation of reserves in nutritive cells at different seasons, while individuals from San Jorge Gulf had mature gametes during most of the year. Interannual variation of seawater temperature affected the gamete production and spawning duration in both populations. Higher temperatures during gametogenesis enhanced gonadal growth and gametes were released early. The major population differences found in gonadal cell composition highlights the plasticity in reproductive traits of A. dufresnii, and may be responsible for the wide distribution of A. dufresnii in different environments.","palabras_clave":"Reproduccion|Echinodermata|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":406,"idioma_id":4,"titulo":"Liquid-phase transfer hydrogenation of furfural to   furfuryl alcohol on Cu-Mg-Al catalysts","resumen":"The liquid-phase transfer hydrogenation of furfural on Cu-based catalysts was studied. Catalysts were prepared by incipient wetness impregnation (Cu\/SiO2) and co-precipitation (Cu?Mg?Al). The effect of metal-supportinteraction, hydrogen donor, copper loading and temperature on catalytic performancewas evaluated. Small particles, strongly interacting with a spinel-like matrix, had higher capability for transferring hydrogen than large ones having low interaction with support. An important increase in reaction rate was observed when temperature was raised from110 to 150 °C. Thus, itwas possible to attain complete furfural conversion to furfuryl alcohol with Cu(40%)?Mg?Al after 6 h at 150 °C.","palabras_clave":"HYDROGENATION    |FURFURAL|FURFURYL ALCOHOL|COPPER BASED CATALYSTS|HYDROGEN DONOR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":409,"idioma_id":4,"titulo":"Toxicity of 'Bacillus thuringiensis' var. 'israelensis' in aqueous suspension on the South American common frog 'Leptodactylus latrans' (Anura: Leptodactylidae) tadpoles","resumen":"The effects of commercial formulations of 'Bacillus thuringiensis' var. 'israelensis' (Bti) on non-target organisms are still a matter of debate; in amphibians, therisks of Bti are little known. To evaluate the toxicity of a commercial liquid (aqueous suspension, AS) formulation of Bti (Introbans) on 'Leptodactylus latrans' tadpoles, including median lethal concentration (LC50) and no-and lowest?observed-effect concentrations (NOEC and LOEC, respectively), as well as the possible effects of Bti on oxidative responses, erythrocytes genotoxicity, and histology of the intestines. In the laboratory, tadpoles were exposed to nominal concentrations of 0 (control), 2.5, 5, 10, 20 and 40 mg\/L of formulated Bti-AS. Glutathione S-transferase (GST) and catalase (CAT) activities, as well as formation of erythrocyte nuclear abnormalities (ENAs), and histological effect were measured in tadpoles displaying survival rates &gt;85%. 'L. latrans' tadpoles were sensitive to exposure to Bti-AS, reaching 100% mortality after 48h of exposure at the highest concentration. Bti-AS induced GST and CAT enzymes and genotoxicity (erythrocyte's nuclear abnormalities), and caused intestine's histopathology. Our resultsd emonstrate that toxicity of Bti-AS isdose-dependent for 'L. latrans' tadpoles and that sublethal exposure alters enzymes of oxidative stress, induces genotoxicity, and cause sintestine damage. Further research is needed to evaluate the ecotoxicological risk of the massive use of Bti formulations on amphibian populations that commonly used suburban wastewater or urban water bodies to reproduce and where this biopesticide is frequently applied.","palabras_clave":"AMPHIBIANS|MORTALITY|BIOPESTICIDES|BIOMARKERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":411,"idioma_id":4,"titulo":"Riboflavin-sensitized Photooxidation of Ceftriaxone and Cefotaxime. Kinetic Study and Effect on Staphylococcus aureus","resumen":"Se adjunta Resumen en .pdf","palabras_clave":"ANTIBIOTICS|RIBOFLAVIN|PHOTOSENSITIZATION|PHOTODEGRADATION|REACTIVE OXYGEN SPECIES|MICROBIOLOGICAL ASSAYS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":413,"idioma_id":4,"titulo":"Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-days oral subchronic toxicity study in rats","resumen":"Minthostachys verticillata (Lamiaceae), popularly known as peperina is largely used in popular medicine for its digestive, carminative, antispasmodic and antirheumatic properties. There are no reports of repeated exposure toxicity to guarantee their safety. The present study investigated the chemical composition, analyzed by GC-FID, and the 90-day toxicity and genotoxicity effect of M. verticillata essential oil (Mv-EO), using Wistar rats as test animals. The rats were divided into four groups (5 rats\/sex\/group) and Mv-EO was administered on diet at doses of 0, 1, 4 and 7 g\/kg feed. The main components of Mv-EO were pulegone (64.65%) and menthone (23.92%). There was no mortality, adverse effects on general conditions or changes in body weight, food consumption and feed conversion efficiency throughout the study in male and female rats. Subchronic administration of Mv-EO did not alter the weights, morphological and histopathological analyses of liver, kidney and intestine. Genotoxicity was tested by micronucleus and comet assays. Mv-EO up to a concentration of 7 g\/kg feed for 90 days did not exert a cyto-genotoxic effect on the bone marrow and cells blood of Wistar rats. These results suggest that Mv-EO appears to be safe and could be devoid of any toxic risk.","palabras_clave":"Minthostachys verticillata|Essential oil|90-Day subchronic toxicity|Genotoxicity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":415,"idioma_id":4,"titulo":"Proteomic and metabolomic profiling of Valencia orange fruit after natural frost exposure","resumen":"The aim of this study was to evaluate the response of orange fruit (Citrus sinensis var. Valencia late) to freezing stress in planta, both immediately after the natural event and after a week, in order to understand the biochemical and molecular basis of the changes that later derive in internal and external damage symptoms. Using two-dimensional differential gel electrophoresis to analyze exposed and non-exposed fruit, 27 differential protein spots were detected in juice sacs and flavedo, among all comparisons made. Also, primary and secondary metabolites relative contents were analyzed in both tissues by GC-MS and LC-MS, respectively. Proteins and compounds involved in regulatory functions, iron metabolism, oxidative damage and carbohydrate metabolism were the most affected. Interestingly, three glycolytic enzymes were induced by cold, and there was an increase in fermentation products (volatiles); all of that suggests that more energy generation might be required from glycolysis to counter the cold stress. Moreover, a notable increase in sugar levels was observed after frost, but it was not at the expense of organic acids utilization. Consequently, these results suggest a probable redistribution of photoassimilates in the frost-exposed plants, tending to restore the homeostasis altered by that severe type of stress. Isosinensetin was the most cold-sensitive secondary metabolite, since it could not be detected at all after the frost, constituting a possible tool to early diagnose freezing damage","palabras_clave":"freezing stress|orange|metabolomic"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":418,"idioma_id":4,"titulo":"Radiocarbon trends in the Pampean region (Argentina). Biases and demographic  patterns during the final Late Pleistocene and Holocene","resumen":"This paper compiles a database of radiocarbon dates of archaeological sites that are currently available for the Pampean region. Based on the probability distribution of radiocarbon dates from this database,  major temporal trends are defined, taphonomic and scientific biases are evaluated, and their implications for demography are suggested. Results indicate a continuous archaeological signal between ca. 14,500  and 100 cal BP. During the final Late Pleistocene and the Early Holocene, the archaeological signal is low in ca. 14,500e12,800 cal BP, and increases to a moderate and continuous signal in ca. 12,800e7500 cal BP.  The archaeological signal for the former lapse correspond to the early peopling of the region and is related to the inhabiting and exploitation of key landforms (e.g., rock shelters, river valleys) and critical  resources (e.g., lithic raw material, water). The low amount of available dates for the Middle Holocene (ca.7400e-700 cal BP), and the associated archaeological signal would be due to the combination of various  factors such as taphonomic biases, organization of prehistoric populations, and even a possible low population density. The obtained low but continuous signal for this period are discussed in the framework  of the proposed models for the human occupation of the region suggesting that a hypothesis about population extinctions and disruptions processes could not be sustained. Finally, during the Late Holocene (from 3700 to 100 cal BP) human occupations are recorded in all the micro-regions. Regardless of biases, this signal is interpreted as an increase in demographic density at a regional level.","palabras_clave":"CHRONOLOGY|PAMPEAN REGION|DEMOGRAPHY|PLEISTOCENE-HOLOCENE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":419,"idioma_id":4,"titulo":"Cyclostratigraphy of an orbitally-driven Tithonian-Valanginian carbonate ramp succession, Southern Mendoza, Argentina: Implications for the Jurassic-Cretaceous boundary in the Neuquén Basin","resumen":"Detailed sedimentological, sequence stratigraphical and cyclostratigraphical analyses have been made from four lower Tithonian-lower Valanginian sections of the Vaca Muerta Formation, exposed in the southern Mendoza area of the Neuquén Basin, Argentina. The Vaca Muerta Formation is characterized by decimetre-scale rhythmic alternations of marls, shales and limestones, and consists of five facies associations, which reflect different paleoenvironmental conditions: basin to restricted outer ramp, outer ramp, and middle ramp. Vertical organization within the Vaca Muerta Formation shows a well-ordered hierarchy of cycles, where elementary cycles, bundles and superbundles with frequencies within the Milankovitch band have been recognized. According to biostratigraphic data, elementary cycles have a periodicity of ~ 20 ky, which correlates with the precession cycle of Earth´s axis. Spectral analysis based on series of cycle thickness allows us to identify frequencies of about 400 ky and 90-120 ky, which we interpret as the modulation of the precessional cycle by the Earth´s orbital eccentricity. Cycles are probably driven by variations in carbonate exportation, as fluctuations in shallow-water carbonate production involve modifications in carbonate basinward exportation. Cyclostratigraphic data allowed us to build a floating orbital scale for the Tithonian-lower Valanginian interval in the Neuquén Basin. Correlation between studied sections allowed us to recognize a discontinuity between the Substeueroceras koeneni and Argentiniceras noduliferum ammonite zones in the Malargüe Anticline area. Orbital calibration of these sections is consistent with Riccardi´s biostratigraphic scheme, wich place the Jurassic-Cretaceous boundary within the Substeueroceras koeneni ammonite Zone. On the other hand, the base of the Vaca Muerta Formation (Virgatosphinctes mendozanus ammonite Zone) would be probably placed in the base of the middle Tithonian rather than the lower Tithonian, which is also consistent with our preliminary palaeomagnetic data","palabras_clave":"ORBITAL CYCLES|MILANKOVITCH|MAGNETOSTRATIGRAPHY|JURASSIC-CRETACEOUS BOUNDARY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":420,"idioma_id":4,"titulo":"Multilocus  sequence typing approach for a broader  range of species of Leishmania genus: Describing parasite diversity in Argentina","resumen":"Leishmaniasis is a vector-borne protozoan infection affecting over 350 million people around the world. In Argentina cutaneous leishmaniasis is endemic in nine provinces and visceral leishmaniasis is spreading from autochthonous transmission foci in seven provinces. However, there is limited information about the diversity of the parasite in this country. Implementation of molecular strategies for parasite typing, particularly multilocus sequence typing (MLST), represents an improved approach for genetic variability and population dynamics analyses. We selected six loci as candidates implemented in reference strains and Argentinean isolates. Phylogenetic analysis showed high correlation with taxonomic classification of the parasite. Autochthonous Leishmania (Viannia) braziliensis showed higher genetic diversity than L. (Leishmania) infantum but low support was obtained for intra-L. braziliensis complex variants suggesting the need of new loci that contribute to phylogenetic resolution for an improved MLST or nested-MLST scheme. This study represents the first characterization of genetic variability of Leishmania spp. in Argentina.","palabras_clave":"Argentina|Leishmania| Multilocus |sequence typing"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":421,"idioma_id":4,"titulo":"Development of a Multilocus Sequence Typing scheme for the study of Anaplasma marginale population structure over space and time","resumen":"Bovine Anaplasmosis caused by Anaplasma marginale is a worldwide disease prevalent in tropical and subtropical regions where Rhipicephalus microplus is considered the most significant biological vector. Molecular markers previously applied for A. marginale typing are efficient for isolate discrimination but they are not a suitable tool for studying population structure and dynamics. Here we report the development of an MLST scheme based on the study of seven genes: dnaA, ftsZ, groEl, lipA, recA, secY and sucB. Five annotated genomes (Saint Maries, Florida, Mississippi, Puerto Rico and Virginia) and 53 bovine blood samples from different world regions were analyzed. High nucleotide diversity and a large proportion of synonymous substitutions, indicative of negative selection resulted from DnaSP 5.00.02 package application. Recombination events were detected in almost all genes, this evidence together with the coexistence of more than one A. marginale strain in the same sample might suggest the superinfection phenomena as a potential source of variation. The allelic profile analysis performed through GoeBURST shown two main CC that did not support geography. In addition, the AMOVA test confirmed the occurrence of at least two main genetically divergent groups. The composition of the emergent groups reflected the impact of both historical and environmental traits on A. marginale population structure. Finally, a web-based platform ?Galaxy MLST-Pipeline? was developed to automate DNA sequence editing and data analysis that together with the Data Base are freely available to users.The A. marginale MLST scheme developed here is a valuable tool with a high discrimination power, besides PCR based strategies are still the better choice for epidemiological intracellular pathogens studies. Finally, the allelic profile describe herein would contribute to uncover the mechanisms in how intracellular pathogens challenge virulence paradigm.","palabras_clave":"Anaplasma Marginale|MLST|Bioinformatics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":423,"idioma_id":4,"titulo":"Blasting and passivation treatments for ASTM F139 stainless steel for \tbiomedical applications: Effects on surface roughness, hardening and \tlocalized corrosion","resumen":"Due to the combination of good biofunctionality and biocompatibility at low cost, AISI 316 low carbonvacuum melting (LVM) stainless steel, as considered in ASTM F139 standard, is often the first choice formedical implants, particularly for use in orthopedic surgery. Proper surface finish must be provided toensure adequate interactions of the alloy with human body tissues that in turn allows the material to deliverthe desired performance. Preliminary studies performed in our laboratory on AISI 316LVM stainless steelsurfaces modified by glass bead blasting (from industrial supplier) followed by different nitric acid passivationconditions disclosed the necessity to extend parameters of the surface treatments and to furtherconsider roughness, pitting corrosion resistance, and surface and subsurface hardening measurements, allin one, as the most effective characterization strategy. This was the approach adopted in the present work.Roughness assessment was performed by means of amplitude parameters, functional parameters, and anestimator of the fractal dimension that characterizes surface topography. We clearly demonstrate that theblasting treatment should be carried out under controlled conditions in order to obtain similar surface andsubsurface properties. Otherwise, a variation in one of the parameters could modify the surface properties,exerting a profound impact on its application as biomaterial. A passivation step is necessary to offset thedetrimental effect of blasting on pitting corrosion resistance.","palabras_clave":"316 LVM STAINLESS STEEL| CORROSION|GLASS BEAD BLASTING| HARDNESS|NITRIC ACID PASSIVATION|ROUGHNESS PARAMETERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":424,"idioma_id":4,"titulo":"Arsenic-bearing phases in South Andean volcanic ashes: implications for As mobility in aquatic environments","resumen":"Three samples of volcanic ashes collected after eruptions of the volcanos Hudson in 1991, Chaitén in 2008 and  Puyehue in 2011 were analyzed in order to define the solid speciation of arsenic and the dynamics of its release  to the aqueous phase. The bulk chemical and mineralogical characterization of the samples was performed by  ICP\/OES, DRX, and SEM\/EDS analyses. The chemical composition of the near surface region (first 2?10 nm),  along with the As and Fe solid speciation was performed by XPS. Batch experiments were conducted to evaluate  the kinetics of the arsenic release under variable pH conditions. The integrated analysis of these data indicates  that arsenic compounds are concentrated onto the ash surface in the form of As(III)?S and As(V)?O species.  The As(III) species have been assigned to arsenian pyrite, while As(V)?O compounds have been assigned to  adsorbed arsenate ions or Fe arsenate salts precipitated as thin coatings.  Although the main As carrier in the studied volcanic ashes is Al-silicate glass, this phase is stable at the neutral pH  that dominates the aqueous reservoirs of the area affected by ashfall. Thus, its contribution to the pool of dissolved  arsenic is minor. Higher contributions are clearly associated with the more mobile As species that concentrate  onto the surface of Al-silicate glass. Thismore available arsenic represents less than 6% of the totalmeasured  arsenic.","palabras_clave":"volcanic glass|XPS|As-solid speciation|salt coatings"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":427,"idioma_id":4,"titulo":"Effects of nitric oxide on sunflower seedlings: A balance between defense and development","resumen":"Nitric oxide (NO) is a major plant signaling molecule that plays key roles during plant-pathogen interactions and plant development. Previous work showed the participation of NO in the development and lignin composition of sunflower roots. Thereby, we have hypothesized that NO applications could control the attack of the fungal pathogen Verticillium dahliae in sunflowers. Seedlings growing hydroponically were pretreated with NO donors and further inoculated with the fungus. Evaluation of disease symptoms showed that NO pretreatments could not reduce Verticillium wilt. Strikingly, NO donors appear to promote the fungal infection. These results indicate that NO applications were unable to protect sunflowers from Verticillium attack and highlight the role played by the fine tuning regulation of NO levels required to balance plant responses between development and defense.","palabras_clave":"fungal control|Helianthus annuus|lignin|nitric oxide"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":436,"idioma_id":4,"titulo":"Effects of detyrosinated tubulin on Na + ,K + -ATPase activity and erythrocyte function in hypertensive subjects","resumen":"Formation of tubulin\/Na(+),K(+)-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination\/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development.","palabras_clave":"TUBULIN|TYROSINE|HYPERTENSION|ERITHROCYTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":438,"idioma_id":4,"titulo":"The hip adductor muscle group in caviomorph rodents: anatomy and homology","resumen":"Anatomical comparative studies including myological data of caviomorph rodents are relatively scarce,leading to a lack of use of muscular features in cladistic and morphofunctional analyses. In rodents, thehip adductor muscles constitute an important group of the hindlimb musculature, having an importantfunction during the beginning of the stance phase. These muscles are subdivided in several distinct waysin the different clades of rodents, making the identification of their homologies hard to establish. In thiscontribution we provide a detailed description of the anatomical variation of the hip adductor musclegroup of different genera of caviomorph rodents and identify the homologies of these muscles in thecontext of Rodentia. On this basis, we identify the characteristic pattern of the hip adductor musclesin Caviomorpha. Our results indicate that caviomorphs present a singular pattern of the hip adductormusculature that distinguishes them from other groups of rodents. They are characterized by havinga single m. adductor brevis that includes solely its genicular part. This muscle, together with the m.gracilis, composes a muscular sheet that is medial to all other muscles of the hip adductor group. Bothmuscles probably have a synergistic action during locomotion, where the m. adductor brevis reinforcesthe multiple functions of the m. gracilis in caviomorphs. Mapping of analyzed myological charactersin the context of Rodentia indicates that several features are recovered as potential synapomorphiesof caviomorphs. Thus, analysis of the myological data described here adds to the current knowledge ofcaviomorph rodents from anatomical and functional points of view, indicating that this group has featuresthat clearly differentiate them from other rodents.","palabras_clave":"CAVIOMORPHA|HOMOLOGY|MUSCULATURE|EVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":441,"idioma_id":4,"titulo":"Authentication and Discrimination of Whiskies of High  Commercial Value by Pattern Recognition","resumen":"An analytical method for a rapid and non-destructive classification and authentication of whiskies of high commercial value based on trademark and years of aging is presented. Molecular absorption spectroscopy was performed with a minimum manipulation of the sample. Different conditions previous to the chemometric analysis, such as dilution and pH effect were studied. Fifteen commercial trademarks of whiskies with different years of aging were acquired from the local market. The pattern recognition was performed using principal component analysis (PCA), linear discriminant analysis (LDA) and partial least squares discriminant analysis (PLS-DA) to obtain models that allowed the classification and discrimination of whiskies based in trademarks and years of aging respectively. Results show that by LDA, a mean of 99.15% of samples were correctly classified according to trademark. On the other hand, by PLS-DA a 100% of correct classification and discrimination was achieved with several aging labels (6, 8, 12 and 15 years of aging).","palabras_clave":"WHISKIES|TRADEMARK|YEARS OF AGING|CLASSIFICATION|DISCRIMINATION|PATTERN RECONGNITION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":442,"idioma_id":4,"titulo":"Optimization of pancreatic trypsin extraction in PEG\/citrate aqueous two-phase systems","resumen":"Enzyme extraction using aqueous two-phase systems (ATPS) has been increasingly used as a primary recovery technique which integrates the clarification, concentration and partial purification of important biomolecules from their natural source in a single step. The goal of this work was to optimize the extraction of trypsin from pancreas homogenate with polyethylene glycol and sodium citrate (PEG\/NaCit) ATPS by using the tools of experimental design.  The variables NaCl concentration ? added inert salt , the top\/bottom phase volume ratio ? Vr ? and the biomass loaded into the system ? in percentage ? were selected as the main factors in the trypsin extraction.  The yield (%) and the purification factor of trypsin were considered the responses to be optimized. The central composite design and the response surface analysis proved to be suitable tools for a quick and efficient study. As a result, the optimal extraction conditions in PEG3350\/NaCit system were 3.34%  wt\/wt for NaCl concentration, a biomass load which represented 9.30% wt\/wt of the total ATPS mass and 6.37 top\/bottom volume ratio giving a purification factor of 2.55 and a yield of 99.7% in top phase.","palabras_clave":"PANCREATIC TRYPSIN|EXTRACTION|AQUEOUS TWO-PHASE SYSTEM|STATISTIC OPTIMIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":453,"idioma_id":4,"titulo":"Cadmium induces different biochemical responses in wild type and catalase-deficient tobacco plants","resumen":"The response of tobacco (Nicotiana tabacum L.) wild type SR1 and catalase-de&#64257;cient CAT1AS plants was  evaluated after exposure to CdCl2. CAT1AS plants accumulated more Cd than SR1 plants, and this was  associated with reduced growth, but higher chlorophyll content and cell viability. Despite catalase de&#64257;-  ciency, CAT1AS plants did not accumulate moreH2O2 than the wild line when exposed to Cd, probably due  to the fact that CAT1AS plants counterbalanced their catalase de&#64257;ciency by increasing the constitutive  guaiacol peroxidase and ascorbate peroxidase activities and by reducing the basal NADPH oxidase-like  enzyme activity. Both lines could activate their antioxidant system upon Cd stress, although the stress  response pathways showed wide differences in the mineral and nitrogen metabolism, since the wild-type  line had reduced nitrates and iron content, while CAT1AS maintained the same level of nitrates and Fe  than that of non-treated plants, and responded with a signi&#64257;cant increase in proline. The results showed  that, unlike previous reports using other type of stress with the same line plants, catalase did not play a  crucial role in protecting against Cd toxicity and CAT1AS plants, compared to SR1, were able to activate  alternative defence mechanisms against Cd toxicity.","palabras_clave":"CADMIUM|TOBACCO|PLANTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":455,"idioma_id":5,"titulo":"Abuso sexual en la infancia y ética profesional. algunas consideraciones sobre la responsabilidad del psicólogo a partir del film Jagten","resumen":"¿Cómo debería proceder un profesional de la salud frente a una sospecha de abuso sexual infantil? Desde el marco deontológico, la normativa es clara: según la Ley 24.417 de Protección contra la violencia familiar y el decreto reglamentario de la ley se establece un plazo para llevar a cabo la denuncia. Ese plazo es un margen flexible que introduce la normativa donde prima el criterio profesional, es decir se pone en juego la dimensión de juicio crítico que supone la ética en situación, pudiendo el psicólogo disponer de un tiempo acotado para intentar alguna maniobra terapéutica que haga cesar el abuso. Sin embargo, en casos como estos es necesario hacer intervenir a la justicia (vía la denuncia) que al operar como Otro de la ley introduce la instancia de sanción social, punto de partida insoslayable para esta problemática. A partir de la Convención Internacional sobre los Derechos del Niño (CDN) que introduce un nuevo paradigma jurídico, social y político respecto de la niñez, analizaremos los alcances de la noción de autonomía progresiva con respecto al interés superior del niño. El film La Caza (Jacten, Vinterberg 2012)  se presenta como escenario privilegiado para reflexionar en torno a las complejidades deontológicas y clínicas del derecho del niño a ser oído; la dialéctica autonomía- vulnerabilidad y las implicancias subjetivas del rol del psicólogo en estos casos.","palabras_clave":"etica|secreto profesional|abuso sexual |infancia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":459,"idioma_id":4,"titulo":"A branch-and-price algorithm for the (k,c)-coloring problem","resumen":"In this article, we study the (k,c)-coloring problem, a generalization of the vertex coloring problem where we have to assign k colors to each vertex of an undirected graph, and two adjacent vertices can share at most c colors. We propose a new formulation for the (k,c)-coloring problem and develop a Branch-and-Price algorithm. We tested the algorithm on instances having from 20 to 80 vertices and different combinations for k and c, and compare it with a recent algorithm proposed in the literature. Computational results show that the overall approach is effective and has very good performance on instances where the previous algorithm fails.","palabras_clave":"VERTEX COLORING|MULTICOLORING|BRANCH AND PRICE|COLUMN GENERATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":468,"idioma_id":5,"titulo":"Nuevos aportes al conocimiento de Trichinella y Trichinellosis","resumen":"La trichinellosis es una zoonosis parasitaria que se encuentra distribuida alrededor del mundo. Es endémica en Argentina y constituye un grave problema de salud pública, dadas las tasas altas de morbilidad que presenta. El hombre y una amplia variedad de animales se infectan al consumir carne cruda o poco cocida infectada con larvas del nematode. Hasta el momento, nueve especies y tres genotipos de Trichinella fueron descubiertos en un amplio rango de animales incluyendo mamíferos, aves y reptiles tanto en el ámbito doméstico como silvestre. En un comienzo, la trichinellosis en el hombre estaba estrechamente relacionada con el consumo de carne de cerdo doméstico, sin embargo el descubrimiento de nuevas especies nos ha conducido a un cambio en el estudio de la epidemiologia de la enfermedad con la incorporación de nuevas fuentes de infección como la carne proveniente de equinos, pumas, jabalíes entre otros. El estudio de las características propias de cada especie y genotipo de Trichinella nos permiten conocer aquellos puntos sobre los cuales implementar medidas de control para evitar la infección en el hombre y para minimizar la dispersión del parásito en el ambiente","palabras_clave":"TRICHINELLA|CERDOS|DIAGNOSTICO|EPIDEMIOLOGIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":470,"idioma_id":4,"titulo":"'Efficient removal of Orange G using Prussian Blue nanoparticles supported over alumina?","resumen":"Prussian Blue nanoparticles (PBNP) synthetized and adsorbed onto g-Al2O3 spheres were prepared and characterized by SEM, EDS and sorptometry. Adsorption and reaction runs were performed using aqueous solutions of a model azo dye Orange G. The adsorption capacity of the PBNP\/g-Al2O3 at 323 and 343K at initial pH 3 and 6 was studied. The presence of PBNP increased the adsorption capacity of the support and this effect was more pronounced at initial pH 6. However, since the adsorbent life time was narrow and its regeneration quite difficult, PBNP\/g-Al2O3 was tested as a heterogeneous Fenton-like catalyst. The catalytic activity and stability for oxidation of Orange G were investigated in terms of discolouration, TOC consumption and oxidant conversion.  At the best operating condition studied (343K and pH0=3), complete dye discolouration and 60% of mineralization were attained while reaction largely overcomes adsorption. At this temperature the catalyst activity and its characteristics remained almost invariable during 9 cycles of 5h each and iron leaching occurred in low extent.","palabras_clave":"HETEROGENEOUS FENTON LIKE OXIDATION|PRUSSIAN BLUE NANOPARTICLES|AZO DYE|ALUMINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":478,"idioma_id":4,"titulo":"First record of fossil woods from the Mariño Formation (Miocene), Mendoza, Argentina and their palaeobiogeographical implications","resumen":"The first Miocene records of silicified fossil woods from the Mariño Formation, Potrerillos area, Andes Precordillera, Mendoza province, Argentina  are described. Rhaphithamnoxylon artabeae gen. et sp. nov. is described as the first fossil wood referable to Verbenaceae from Argentina. This new  fossil species is related to extant Rhaphithamnus Miers, sharing the following anatomical features: diffuse porosity, distinct growth ring boundaries,  numerous small to very small vessels, commonly in radial multiples, 1?3 seriate rays, and heterocellular and scarce paratracheal axial parenchyma.  Rhaphithamnus contains only two extant species: R. spinosus (A.L. Juss.) Moldenke, which occurs in the Valdivian forests of Chile and Argentina,  and R. venustus (Philippi) Robinson, which is endemic to the Juan Fernández Islands. Representatives of Verbenaceae are distributed predominantly  in the Americas from Patagonia (Argentina) to Canada, and they are inferred to have originated in South America. The fossil wood described  herein provides new age and geographical constraints on the raphithanoid lineage within Verbenaceae. Other fossil woods recorded from the  Mariño level are retained under open nomenclature, as they possess a combination of mostly solitary broad vessels, and smaller vessels in radial  multiples or in clusters, with numerous, vasicentric to confluent axial parenchyma, and heterocellular, high rays. Thus, they have features akin to  dicotyledonous lianas or vine-like or small shrub species.","palabras_clave":"FOSSIL WOODS|MARIÑO FORMATION|MIOCENE|VERBENACEAE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":479,"idioma_id":4,"titulo":". Chemical conversion of paper industry effluents into carboxymethylcellulose","resumen":"The synthesis of carboxymethylcellulose was investigated using effluents containing short cellulose fibers. Carboxymethylcellulose was synthesized according to the slurry process using different amount of sodium ydroxide and different incubation times at 30&#9702;C after the etherification reaction as variables. Characterization of the product was conducted by Fourier transformed infrared spectroscopy, X-ray diffraction, degree of substitution, average degree of polymerization, water imbibing capacity, color, rheological properties, apparent viscosity and trace elements content. Incubation time slightly increased the yield of the reaction and the degree of substitution during the first 12h. The reaction yield and degree of substitution both decreased when the initially concentration of NaOH was increased from 7.0 g\/mL to 10.5 g\/mL. The carboxymethylcellulose obtained was darker and had lower hydration properties than commercial samples. Trace elements content suggests that the product could be only used in paint factories or building materials industries.","palabras_clave":"SHORT CELLULOSE FIBERS|CARBOXYMETHYLCELLULOSE|PAPER |RECYCLED SLUDGE| EFFLUENTS|SOLID WASTE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":484,"idioma_id":5,"titulo":"Depredación de Erythrolamprus poecilogyrus (Serpentes: Dypsadidae) por Lethocerus annulipes (Heteroptera: Belostomatidae)","resumen":"El 15 Octubre de 2012, a las 19:56 hs. en la Estancia Santo Domingo, Dpto. Paso de los Libres, provincia de Corrientes (29°36?2.10?S, 56°59?23.10?O) se observó un ejemplar hembra de L. annulipes (7,05 cm longitud total) depredando sobre un ejemplar macho de la especie Erythrolamprus poecilogyrus (Wied-Neuwied, 1825) (40,5 cm longitud total). El evento se registró en una charca temporaria de 10 m de largo por 1 m de ancho aproximadamente, con una profundidad de 30 cm. La temperatura del aire y del agua al momento de la captura fue de 21°C y 24°C respectivamente. Al momento de la observación la serpiente se encontraba sin vida.","palabras_clave":"DEPREDACION|REPTIL|LETHOCERINAE|CORRIENTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":486,"idioma_id":4,"titulo":"Efficacy of corn silage inoculants on the fermentation quality under farm conditions and their influence on Aspergillus parasitucus, A. flavus and A. fumigatus determined by q-PCR","resumen":"Laboratory-scale silos were prepared to evaluate the efficacy of two different lactic acid bacteria (LAB) on the fermentation quality and mycobiota of corn silage. Their influence on Aspergillus species? variability by using the q-PCR technique was studied. Silage inoculated with Lactobacillus rhamnosus RC007 or L. plantarum RC009 were compared with uninoculated silage. Silos were opened after 1, 7, 45, 90 and 120 days after ensiling. At the end of the ensiling period, silos were left open for 7 days to evaluate aerobic stability. Rapid lactic acid production and decline in pH values were seen in the early stages of fermentation in silage inoculated with L. rhamnosus RC007. After aerobic exposure, a significant decline in lactic acid content was observed in untreated and L. plantarum RC009-inoculated silages. Counts for yeasted and toxigenic fungus remained lower, after aerobic exposure, in L. rhamnosus RC007-inoculated silage, in comparison with L. plantarum RC009 and uninoculated silages. Comparing the influence exerted by both BAL, it was observed that L. rhamnosus RC007 was more efficient at inhibiting the three fungal species tested whose DNA concentrations, determined by q-PCR, oscillated near the initial value (pre-ensiling maize). The ability of L. rhamnosus RC007 to produce lactic acid rapidly and the decline in pH values in the early stages of the fermentation along with the reduction of yeast and mycotoxicogenic fungus after aerobic exposure shows its potential as a bio-control inoculant agent in animal feed.","palabras_clave":"LACTIC ACID BACTERIA|SILAGE QUALITY|AEROBIC STABILITY|Q-PCR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":494,"idioma_id":4,"titulo":"Potential antithrombotic activity detected in Amaranth proteins and its hydrolysates","resumen":"Amaranth protein isolate and fractions were obtained and subjected to proteolysis in order to evaluate its potential antithrombotic activity. The proteins were first hydrolyzed with alcalase (pH 10, 37 C) and then with trypsin (pH 8, 37 C). The samples were characterized physicochemically and antithrombotic activity was evaluated using clotting tests (PT, TT and APTT) and the microplates assay. The fractions compared to the hydrolysates exhibited different electrophoretic profiles (tricine-SDSPAGE) and gel filtration chromatograms, evidencing the presence of different molecular species. The hydrolysis improved in every sample the bioactivity detected, excepting for the glutelin fraction, which exhibited the highest antithrombotic activity, significantly superior (p < 0.05) compared to the other fractions and the isolate. This behavior was observed in the two assays that analyzed the common path of the coagulation cascade at similar concentrations: TT (81.0 ± 8.5 s with a control of 19.5 ± 0.7 s) and microplate test (IC50 80 mg\/mL), indicating a possible mechanism of action that involves the thrombin activity or thepolymerization of fibrin monomers. The glutelin fraction showed a potential capacity to inhibit coagulation, appearing as a promising ingredient to formulate functional foods.","palabras_clave":"AMARANTH|PROTEINS|ANTITHROMBOTIC|ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":496,"idioma_id":4,"titulo":"Application of the LIBS technique to the study of fast impurities  diffusion in Zr based alloys","resumen":"The following paper presents a significant advance in the study of the interdiffusion between Zr-2.5wt%Nb and ASTM 410 martensitic grade stainless steel by means of LIBS (Laser Induced Breakdown Spectroscopy) technique. Both materials are very important in the nuclear industry. Interdiffusion profiles show a slow diffusion of Zr and Nb in the steel matrix, as well as a fast diffusion of Fe, C and Cr in the matrix of the Zr-base alloy. Also, the formation of intermetallic phases was observed by scanning electron microscopy. In addition, diffusivity values of Cr and Fe in the Zr-based alloy were determined at 900ºC.","palabras_clave":"LIBS, |diffusion, |nuclear materials."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":497,"idioma_id":4,"titulo":"Neonatal exposure to low doses of endosulfan induces implantation failure and disrupts uterine functional differentiation at the pre-implantation period in rats","resumen":"We investigated whether neonatal exposure to low doses of endosulfan   affects fertility and uterine functional differentiation at   pre-implantation in rats. Newborn female rats received the vehicle, 0.2   &#956;g\/kg\/d of diethylstilbestrol (DES), 6 &#956;g\/kg\/d of endosulfan (Endo6) or   600 &#956;g\/kg\/d of endosulfan (Endo600) on postnatal days (PND) 1, 3, 5, and   7. On PND90, the rats were mated to evaluate their reproductive   performance on gestational day (GD) 19 and their ovarian steroid serum   levels, endometrial proliferation and implantation-associated proteins   on GD5. DES and endosulfan decreased the pregnancy rate and the number   of implantation sites. On GD5, DES and endosulfan did not change the   serum levels of 17&#946;-estradiol (E2) and progesterone (P); the endometrial   proliferation decreased, which was associated with silencing of Hoxa10   in the Endo600-treated rats. Both doses of endosulfan increased the   progesterone receptor (PR) expression, whereas the higher dose led   additionally to an increase in estrogen receptor alpha (ER&#945;). In the   Endo600-treated rats, the down-regulation of Hoxa10 was associated with a   deregulation of the steroid receptor coregulators. Alterations in   endometrial proliferation and the endocrine pathway of Hoxa10\/steroid   receptors\/coregulators might be the mechanism of endosulfan-induced   implantation failure.","palabras_clave":"ENDOSULFAN|UTERUS|IMPLANTATION|ESTROGEN RECEPTOR ALPHA|PROGESTERONE RECEPTOR|HOXA10"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":505,"idioma_id":4,"titulo":"Mycorrhizal fungi isolated from native terrestrial orchids of pristine regions in Córdoba (Argentina)","resumen":"Orchidaceae is a highly dependent group on the Rhizoctonia complex that includes Ceratorhiza,Moniliopsis, Epulorhiza and Rhizoctonia, for seed germination and the development of new orchid plants. Thus,the isolation and identification of orchid mycorrhizal fungi are important to understand the orchid-fungus relationship, which can lead to the development of efficient conservation strategies by in vivo germination of seeds from endangered orchid plants. The aim of our work was to isolate and characterize the different mycorrhizal fungi found in roots of terrestrial orchids from Córdoba (Argentina), and, to learn about the natural habit and fungal associations in the Chaco Serrano woodland pristine region. In this study, bloomed orchid root and rhizosphere soil samples were obtained in two times from Valle de Punilla during spring of 2007; samples were kept in plastic bags until processed within 48 hours, and mycorrhizal condition confirmed assessing peloton presence. A total of 23 isolates of the orchideous mycorrhizal Rhizoctonia complex were obtained. The isolates werestudied based on morphological characters and ITS-rDNA sequences. Morphological characteristics as color of colonies, texture, growth rate, hyphal diameter and length and presence of sclerotia were observed on culture media. To define the number of nuclei per cell, the isolates were grown in Petri dishes containing water-agar (WA) for three days at 25°C and stained with Safranine-O solution. The mycorrhizal fungi were grouped into binucleate (MSGib, 10 isolates) and multinucleate (MSGim, 13 isolates) based on morphological characteristicsof the colonies. We obtained the ITS1-5.8s-ITS4 region that was amplified using primers ITS1 and ITS4. Based on DNA sequencing, isolates Q23 and Q29 were found to be related to species of Ceratobasidium. Isolates Q24 and Q4 were related to the binucleated anastomosis group AG-C of Rhizoctonia sp. The rest of the isolates grouped in the Ceratobasidium clade without grouping. From our knowledge this is the first report of the association of the AG-C testers with terrestrial orchids. A high specificity was observed in the symbiotic relationship. As the mycorrhizal fungal isolates were obtained from native orchids, they could be incorporated in conservation programes of endangered orchids in Argentina","palabras_clave":"Rhizoctonia|Epulorhiza|terrestrial orchids|mycorrhiza|ITS-rDNA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":514,"idioma_id":4,"titulo":"Monitoring of regional lake water clarity using Landsat imagery","resumen":"The application of remote sensing technology to water quality monitoring has special significance for lake management at regional scale. Water clarity expressed in terms of Secchi disk transparency (SDT) is a highly useful indicator of trophic status and ecosystem health. In this study, we related Landsat TM and ETM+ data with ground observations to develop a model for the estimation of SDT which can be used as a standardized procedure for regional-scale lake clarity assessment in the central region of Argentina. Samples were taken from two reservoir of the region. Pearson correlation coefficients and step-wise multiple regression analysis were used to evaluate correlation between Landsat bands and measured SDT. Results suggested that Landsat band 3 plus the ratio 1\/3 was a consistent and reliable predictor of SDT (R2=0.80). The algorithm was validated (R2=0.81) and applied to the November 10, 2010 ETM+ image obtaining a map that characterized water clarity of reservoirs within the study area. The procedure presented here could become a low cost measurement tool for water management authorities and decision makers, obtaining simpler and practical results for regional water clarity monitoring.","palabras_clave":"ALGORITHM|LANDSAT|REMOTE SENSING|WATER CLARITY|RESERVOIR|SECCHI DISK|TRANSPARENCY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":515,"idioma_id":4,"titulo":"Effects of temozolomide (TMZ) on the expression and interaction of heat shock proteins (HSPs) and DNA repair proteins in human malignant glioma cells","resumen":"molecular markers were associated with high-grade astrocitomas suggesting that these  markers are related with the disease outcome and the response to treatments. With the  aim to better understand of resistance\/susceptibility processes associated to TMZ  treatment, we have studied the biological effects of TMZ administration in human  glioma cell lines evaluating the expression levels of proteins related to treatment  resistance and DNA repair.  Methods: Three human glioma cell lines: Gli36, U87 and DBTRG were treated  with TMZ. The biological effects of drug were evaluated through different biological  assays (viability, survival, apoptosis by TUNEL, senescence and comet). The  expression of HSPA, HSPB1, MGMT, MLH1 and MSH2 were evaluated by  immunocytochemical, immunofluorescence and western blot. Immunoprecipitation  technique was used to analyze the protein interaction.  Results: The cell lines exhibited different viability, apoptosis and senescence  after TMZ administration. Gli36 cells showed very low recovery capacity following  TMZ administration and this was related to high DNA damage levels, however, the  cells maintained their viability. In these cells MGMT, MSH2, HSPA and HSPB1 levels  increased significantly after TMZ administration. MSH2 and HSPB1 proteins appeared  colocalized in Gli36 cells by confocal microscopy. This colocalization increased after  TMZ treatment. In immunoprecipitation analysis MSH2 and HSPB1 appeared  interacting. In contrast, HSPB1 did not interact with MGMT.  Conclusion: This is the first report on the interaction of HSPB1 with a protein of  the MMR system following TMZ administration in glioma cells.  Key Words: temozolomide, glioma, heat shock protein, mismatch repair, MGMT      Nadin SB and Ciocca DR equally contributed to this work.","palabras_clave":"TEMOZOLOMIDE|GLIOMA|HSPB1|MSH2|MGMT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":516,"idioma_id":4,"titulo":"Comparison of the performance of flow-by three-dimensional cylindrical electrochemical reactors with inner or outer counter electrode under limiting current conditions","resumen":"The influence of the position of the counter electrode on the behaviour of a cylindrical electrochemical reactor with a three-dimensional electrode in flow-by configuration is analysed. Experimental results of the potential distribution are compared with theoretical predictions obtaining a close agreement between them. The best performance was observed for the arrangement with an outer counter electrode, where the largest bed thickness is obtained for a given potential difference in the three-dimensional structure; which, under limiting current conditions, tolerates a higher current increasing the conversion per pass. The reactor was also checked for the removal of copper from dilute solutions and the experimental results coincide with the theoretical predictions. The morphology of the electrodeposited copper is discussed as a function of the radial position inside the three-dimensional structure.","palabras_clave":"ELECTROCHEMICAL REACTORS|MASS-TRANSFER COEFFICIENT|METAL REMOVAL|POTENTIAL DISTRIBUTION|THREE-DIMENSIONAL ELECTRODES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":517,"idioma_id":4,"titulo":"Evidences of local adaptation in quantitative traits in Prosopis alba (Leguminosae)","resumen":"Signals of selection on quantitative traits can be  detected by the comparison between the genetic differentiation  of molecular (neutral) markers and quantitative  traits, by multivariate extensions of the same model and by  the observation of the additive covariance among relatives.  We studied, by three different tests, signals of occurrence  of selection in Prosopis alba populations over 15 quantitative  traits: three economically important life history  traits: height, basal diameter and biomass, 11 leaf morphology  traits that may be related with heat-tolerance and  physiological responses and spine length that is very  important from silvicultural purposes. We analyzed 172  G1-generation trees growing in a common garden  belonging to 32 open pollinated families from eight sampling  sites in Argentina. The multivariate phenotypes differ  significantly among origins, and the highest differentiation  corresponded to foliar traits. Molecular genetic markers  (SSR) exhibited significant differentiation and allowed us  to provide convincing evidence that natural selection is  responsible for the patterns of morphological differentiation.  The heterogeneous selection over phenotypic traits  observed suggested different optima in each population and  has important implications for gene resource management.  The results suggest that the adaptive significance of traits should be considered together with population provenance  in breeding program as a crucial point prior to any selecting  program, especially in Prosopis where the first steps are  under development.","palabras_clave":"ADAPTATION|NEUTRALITY TEST|SELECTION|PROGENY TRIALS|QUANTITATIVE GENETICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":520,"idioma_id":4,"titulo":"Thermodynamics of atomic ordering in Cu-Zn-Al: A Monte Carlo study","resumen":"We present a study of the short- and long- range ordering phenomena that take place in the bcc b phase of the ternary alloy Cu?Zn?Al. The results have been obtained by means of Monte Carlo simulations based on a three states Ising Hamiltonian. The evolution of the long- and short-range order degrees, internal energy, entropy and Helmholtz free energy are calculated as functions of temperature. The impact of short range order on the&nbsp; thermodynamics of the system is evaluated. The results obtained with the Monte Carlo technique are contrasted with those obtained within two different analytical approximations, whose validity is discussed. The calculated thermal variation of the specific heat near the long range ordering transitions is discussed and compared with experimental data.&nbsp;","palabras_clave":"Cu Zn Al |ATOMIC ORDERING|MONTE CARLO METHOD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":524,"idioma_id":4,"titulo":"Drivers shaping phytoplankton diversity and composition in a humid Pampean floodplain lake (Natural Reserve)","resumen":"We aimed to identify the driver\/s of  phytoplankton diversity (gamma, beta, alpha) and  community composition in a Pampean &#64258;oodplain  wetland (Otamendi), using species and functional  groups. We performed a seasonal regional survey  (2004?2006, phytoplankton regime) across the different  aquatic systems in the wetland. Gamma diversity  was 254 species. Beta diversity was 2.53 in late spring,  2.49 in winter, and was lowest in summer (2.05) when  the wetland was over &#64258;ooded. Alpha diversity (mean  richness) ranged between 29 and 50 species. Multiple  regressions showed that phytoplankton alpha diversity  (richness, Shannon?Wiener, evenness, and Simpson  diversity index) responded to dissolved inorganic  nitrogen, suspended solids, light attenuation, and pH.  Nutrients also explained well the distribution of  phytoplankton functional groups. Dissolved inorganic  nitrogen concentrations were usually limiting in the  shallow lakes, whereas phosphate concentration was  always high. Light attenuation was mostly caused by high suspended solids and high humic substances. We  also re-analyzed data from a survey performed during  a free-&#64258;oating plant regime (1998?2000); the dense  macrophyte cover attenuates most incoming light into  the water column. Compared with the phytoplankton  regime, the free-&#64258;oating plant regime had markedly  lower chlorophyll, lower alpha, higher beta (high  heterogeneity among habitats with and without macrophytes),  and similar gamma diversity.","palabras_clave":"PHYTOPLANKTON|FUNCTIONAL GROUPS |DIVERSITY|WETLAND"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":525,"idioma_id":4,"titulo":"Changes in the phytoplankton structure in a Pampean shallow lake in the transition from a clear to a turbid regime","resumen":"We analysed the changes in phytoplankton and in the main limnological features in a shallow lakeduring its transition from a clear-vegetated regime to aturbid one from 2005 to 2013. As samplings werediscontinuous, data were analysed considering threedifferent sampling periods. At the beginning of thefirst period, the lake was in a clear-vegetated regime,showing low values of chlorophyll a, KdPAR, totalsuspended solids and nutrients, and high Secchi depth.Phytoplankton was dominated by nano-phytoplanktonicspecies. During the second period, some evidencesof the shift to a turbid regime were observed(mainly in KdPAR and total suspended solids).Towards the end of our study, submerged macrophytessharply declined; in this period KdPAR and totalsuspended solids noticeably increased, whereas asignificant reduction in Secchi depth occurred. Concomitantly,phytoplankton abundance augmented intwo orders of magnitude, changing to a communitywith a higher proportion of micro-phytoplankton.Although the causes of the regimen shift could not beunequivocally assessed, the drastic reduction in thehydrometric level of the lake probably provoked adeclination in macrophytes, with the consequentincrease of nutrients in the water column and theincrement in phytoplankton densities, carrying thesystem towards a turbid regime.","palabras_clave":"CLEAR AND TURBID REGIME|SHALLOW LAKES|PHYTOPLANKTON|PAMPA PLAIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":534,"idioma_id":4,"titulo":"Is there a relationship between sweet taste and seizures? Anticonvulsant and proconvulsant effects of non-nutritive sweeteners","resumen":"From a virtual screening campaign, a number of artificial and natural sweeteners were predicted as potential anticonvulsant agents with protective effects in the seizure animal model Maximal Electroshock (MES) test. In all cases, the Predictions were experimentally confirmed in the aforementioned preclinical seizure model. The article reviews and expands previous reports from our group on anticonvulsant activity of those non-nutritive sweeteners, illustrating the potential of virtual screening approaches to propose new medical uses of food additives. This constitutes a particular case of knowledge-based drug repositioning and may greatly shorten the development time and investmentrequired to introduce novel medications to the pharmaceutical market. We also briefly overview evidence on possible molecular explanations on the anticonvulsant and proconvulsant effects of different non-nutritive sweeteners. Our analysis ?based on Swanson?s ABC model- suggests that group I metabotropic glutamate receptors and carbonic anhydrase isoform VII (both proposed or validated molecular targets of antiepileptic drugs) might be involved in the anticonvulsant effect of artificial sweeteners. The first hypothesis is in line with recent advances on development of selective modulators of group I metabotropic glutamate receptors as potential antiepileptic agents.","palabras_clave":"DRUG REPOSITIONING|EPILEPSY|MAXIMAL ELECTROSHOCK SEIZURES|NON-NUTRITIVE SWEETENERS|PENTYLENETETRAZOL|STEVIA|STEVIA REBAUDIANA|STEVIOSIDES|CONVULSIONS|SWANSONS ABC MODEL|VIRTUAL SCREENING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":537,"idioma_id":4,"titulo":"The flagellar  adenylate kinases of Trypanosoma cruzi","resumen":"Adenylate kinases (ADK) are key enzymes involved in cell energy  28 management. Trypanosomatids present the highest number of variants in a  29 single cell in comparison with the rest of the living organisms. In this work we  30 characterized two flagellar adenylate kinases from Trypanosoma cruzi, called  31 TcADK1 and TcADK4, which are also located in the cell cytosol. Interestingly,  32 TcADK1 presents a stage specific expression. This variant was detected in  33 epimastigotes cells, and was completely absent in trypomastigotes and  34 amastigotes, while TcADK4 is presents in the major life cycle stages of T. cruzi.  35 Both variants are also regulated, in opposite ways, along the parasites growth  36 curve suggesting that their expression depends on the intra and extracellular  37 conditions. Both, TcADK1 and TcADK4 present N-terminal extension that could  38 be responsible of their subcellular localization. The presence of ADK variants in  39 the flagellum would be critical for the provision of energy in a process of high  40 ATP consumption such as cell motility.","palabras_clave":"Trypanosoma cruzi|Trypanosoma brucei|adenylate kinase|flagellum"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":538,"idioma_id":4,"titulo":"Risk factors associated with failures of Varroa treatments in honey bee colonies without broodless period","resumen":"The treatment against Varroa destructor has become a basic tool in beekeeping practices,mainly during autumn. The treatment effectiveness should be improved by identifying variables affecting the final outcome. The aim of this study was to identify the risk factors associated with the treatment outcome achieved during autumn control of Varroa destructor . The mite infestation after treatment was evaluated in 62 apiaries and data regarding management practices were collected by means of a questionnaire. A mixed-effects model was constructed to associate management variables with the risk of treatment failure occurrence. Colonies with high mite levels prior to treatment (P =0.002) and owned by beekeepers who did not frequently replace queens (P =0.001) were associated with a higher risk of treatment failure. Other beekeeping practices indirectly improved treatment effectiveness. An integrated strategy for controlling mites that includes chemotherapy and suitable beekeepers management is needed to keep mite populations low during winter.","palabras_clave":"VARROA DESTRUCTOR|APIS MELLIFERA|CHEMICAL ACARICIDES|TREATMENT EFFECTIVENESS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":539,"idioma_id":4,"titulo":"Compatibility between entomopathogenic fungi and biorational insecticides in toxicity against Ronderosia bergi under laboratory conditions","resumen":"Our aim was to evaluate the efficacy of combinations between two biorational insecticides (luphenuron, methoxyfenozide), a new synthetic chemical pesticide (rynaxypyr), and three entomopathogenic fungi strains (Beauveria bassiana LPSc 1067, LPSc1082), and Metarhizium anisopliae (LPSc 907) in the biocontrol of the pest grasshopper Ronderosia bergi (Stål) under laboratory conditions. The insecticides were tested at three concentrations: the average concentration recommended for application in the field (100%) and 50% and finally 25% of that level. The fungal strains used were adjusted to 1 x 108, 1 x 106, and 1 x 104 conidia\/ml. The combinations of those insecticides with B. bassiana (LPSc 1067, LPSc 1082) and M. anisopliae (LPSc 907) caused higher mortality to R. bergi nymphs than any of the individual agents used alone. The three insecticides tested did not affect the isolates of the two species of entomopathogenic fungi employed. In conclusion, the use of these biorational insecticides in an IPM program aimed at control of the grasshopper R. bergi could be of value. ","palabras_clave":"GRASSHOPPERS|INTERACTIONS|METARHIZIUM ANISOPLIAE|BEAUVERIA BASSIANA|PESTICIDES|ORTHOPTERA: ACRIDIDAE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":541,"idioma_id":4,"titulo":"Shallow lakes from the Central Plains of Argentina: an overview and worldwide comparative analysis of their basic limnological features","resumen":"The Central Plains of Argentina is a  heterogeneous environment, but the lakes there share  some fundamental features: they are all shallow and  polymictic as being well exposed to wind. First, we  provide a synthesis of the climate, geology, and  hydrological network. We also discussed shallow  lakes origin and their limnological and biological  salient features. Second, we focus on Pampean  shallow lakes from a global perspective, comparing  the limnological variables: total phosphorus concen-  tration (TP), total nitrogen concentration (TN),  chlorophyll a (Chl a) concentrations, and Secchi disk  reading (SD) from a compiled database. No signi&#64257;cant  differences in the Chl a vs. TP relationship were found  between Pampean and other shallow lakes. Otherwise,  the chlorophyll yield per unit of phosphorus of  Pampean lakes is similar to the world shallow lakes  average. Moreover, the relationship SD vs. Chl  a differed signi&#64257;cantly between Pampean and the  remaining world lakes, about 50?60%. When con-  fronted against other lakes worldwide, Pampean  shallow lakes depart from most of them as having  higher TP, TN, and Chl a concentrations and much  lower SD transparency, and therefore they stand as  extremes of the trophic-state continuum. Despite their  highly turbid state, these lakes provide valuable  ecosystem services that are highly appreciated and  mobilize important economic resources.","palabras_clave":"PHOSPHORUS|CHLOROPHYLL|SECCHI DISK|COMPARATIVE LIMNOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":543,"idioma_id":4,"titulo":"Multifilamentary MgB 2 Wires Prepared by an In Situ Powder-in-Tube Method","resumen":"MgB2 has become a commercially attractive material for technologicalapplications for its particular superconducting properties. However, due to its brittleness to obtainwires, a metallic sheath is needed for drawing. In the presentwork, grade 2 titanium has been used as sheath material, and several multifilamentary wires have been prepared. The powder-in-tube method has been used to prepare the wires with the in situ variant, where the sheath is filled with the unreacted precursor powders (Mg and B). Different thermal treatments have been investigated including several intermediate treatments during the drawing process in addition to the final one. This last treatment is necessary to accomplish the synthesis and heal the cracks generated during the cold work. The superconducting properties were determined by magnetization measurements on a SQUID magnetometer, and the microstructure evolution was followed by TEM and SEM microscopy. Mechanical behavior is also evaluated.","palabras_clave":"superconductor|MgB2|cables"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":551,"idioma_id":4,"titulo":"A New Species of Gutierrezia (Asteraceae, Astereae) from Argentina","resumen":"Se describe una nueva especie para la ciencia.","palabras_clave":"TAXONOMIA|ASTERACEAE|GUTIERREZIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":553,"idioma_id":4,"titulo":"Compressed tablets based on mineral-functionalized starch and co-crystallized sucrose with natural antioxidants","resumen":"Compressed tablets based on starch?zinc carriers and co-crystallized   sucrose with yerba mate antioxidants were developed. Firstly, the   zinc-binding capacity of corn starch was evaluated for being used as a   mineral source for the formulations. While, the yerba mate extract was   entrapped within a sucrose matrix by co-crystallization. Then, tablets   were obtained by compression using co-crystallized products alone and   their blends with starch-carriers (85:15, 80:20 and 70:30). All these   formulations led to higher tablet hardness than equivalent blends   containing raw sucrose. However, high dosages of starch-carriers   provoked defects in the tablets (e.g. ?capping?). The weight ratio of   80:20 allowed obtaining tablets with optimal hardness values   (45?55&nbsp;kPa), containing zinc (5.4&nbsp;mg\/g tablet) and yerba mate   polyphenols (1.3&nbsp;mg\/g tablet). These tablets showed low disintegration   times (&lt;10&nbsp;min) and a fast-release in aqueous medium constituting a   useful way for the oral delivery of active compounds with health   benefits.","palabras_clave":"Compressed tablets|Starch; Zinc| Yerba mate|Co-crystallization|Delivery system"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":560,"idioma_id":4,"titulo":"Temporal-spatial correlation between angiogenesis and corticogenesis in the developing chick optic tectum","resumen":"The developing chick optic tectum is a widely used model of   corticogenesis and angiogenesis. Cell behaviors involved in   corticogenesis and angiogenesis share several regulatory mechanisms. In   this way the 3D organizations of both systems adapt to each other. The   consensus about the temporally and spatially organized progression of   the optic tectum corticogenesis contrasts with the discrepancies about   the spatial organization of its vascular bed as a function of the time.   In order to find out spatial and temporal correlations between   corticogenesis and angiogenesis, several methodological approaches were   applied to analyze the dynamic of angiogenesis in the developing chick   optic tectum. The present paper shows that a typical sequence of   developmental events characterizes the optic tectum angiogenesis. The   first phase, formation of the primitive vascular bed, takes place during   the early stages of the tectal corticogenesis along which the large   efferent neurons appear and begin their early differentiation. The   second phase, remodeling and elaboration of the definitive vascular bed,   occurs during the increase in complexity associated to the elaboration   of the local circuit networks. The present results show that, apart from   the well-known influence of the dorsal-ventral and radial axes as   reference systems for the spatial organization of optic tectum   angiogenesis, the cephalic-caudal axis also exerts a significant   asymmetric influence. The term cortico-angiogenesis to describe the   entire process is justified by the fact that tight correlations are   found between specific corticogenic and angiogenic events and they take   place simultaneously at the same position along the cephalic-caudal and   radial axes.","palabras_clave":"Angiogenesis|Neuronal differentiation|Embryos|Digital Imaging|Superior Colliculus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":563,"idioma_id":4,"titulo":"Oxidative stability of walnut (Juglans regia L.) and chia (Salvia hispanica L.) oils microencapsulated by spray drying","resumen":"This work was primarily aimed to evaluate the use of maltodextrin in combination with hydroxypropyl methylcellulose as wall materials for microencapsulation of both walnut and chia oils by spray drying. The effect of rosemary extract on the oxidative stability of the microencapsulated oils was examined under prolonged storage conditions. After a 45-day storage, the microencapsulated chia oil with rosemary extract showed lower formation of primary oxidation compounds than the control without additives, highlighting a protective effect of the antioxidant. Nevertheless, during the entire storage period the unencapsulated chia oil reported lower oxidative damage than their encapsulated counterparts, showing that the spray drying process affected its stability negatively. Walnut oil microencapsulation protected the oil from oxidation in comparison with its unencapsulated counterpart which was further apparent from the 30th day of storage.The addition of 1600 ppm of rosemary extract effectively protected microencapsulated walnut oil, showing - throughout the storage period- lower oxidation values in comparison with its analogous unencapsulated oil. The microcapsule surface oil and the images obtained by scanning electron microscopy at the beginning and at the end of the assay showed that the wall material has not been altered during storag.","palabras_clave":"WALNUT|CHIA|OIL|MICROENCAPSULATION|SPRAY|DRYING|OXIDATIVE|STABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":571,"idioma_id":4,"titulo":"Obituary. In memoriam of Prof. Josué A. Núñez (1924-2014)","resumen":"Prof. Josué Núñez passed away on August 19th 2014 at the age of89. He was a pioneer in the field of insect physiology and a founderof the study of behavioural physiology in Argentina and otherLatin-American countries such as Brazil and Venezuela.","palabras_clave":"obituary|Núñez"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":576,"idioma_id":4,"titulo":"Low Temperature magnetic properties of GdCoIn5","resumen":"A comprehensive experimental and theoretical study of the low temperature properties of GdCoIn5 was performed. Specific heat, thermal expansion, magnetization and electrical resistivity were measured in good quality single crystals down to 4He temperatures. All the experiments show a second-order-like phase transition at 30 K probably associated with the onset of antiferromagnetic order. The magnetic susceptibility shows a pronounced anisotropy below TN with an easy magnetic axis perpendicular to the crystallographic &#265;-axis. Total energy GGA+U calculations indicate a ground state with magnetic moments localized at the Gd ions and allowed a determination of the Gd-Gd magnetic interactions. Band structure calculations of the electron and phonon contributions to the specific heat together with Quantum Monte Carlo calculations of the magnetic contributions show a very good agreement with the experimental data. Comparison between experiment and calculations suggests a significant anharmonic contribution to the specific heat at high temperature (T>100K).","palabras_clave":"GdCoIn5|MAGNETISM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":577,"idioma_id":4,"titulo":"A review of the molar morphology and phylogenetic affinities of Sillustania quechuense (Metatheria, Polydolopimorphia, Sillustaniidae), from the early Paleogene of Laguna Umayo, southeastern Perú","resumen":"The early Paleogene mammalian assemblages known from the red mudstones of the Lower Muñani Formation at Laguna Umayo, southeastern Perú, add significant information on the early phases of the evolution of Metatheria in South America. Two early Cenozoic vertebrate associations have been found from the Laguna Umayo area: localities LU-3 and Chulpas, both including metatherians. The Chulpas local fauna includes at least three indeterminate didelphimorphians and three polydolopimorphians: Chulpasia mattaueri, Chulpasia jimthorselli, and Sillustania quechuense (Sillustanidae). The Laguna Umayo associations have alternatively been referred to the Late Cretaceous or the early Paleogene. The highly derived, enigmatic morphology of the only known upper molar of Sillustania quechuense granted the recognition of a new family of South American metatherians: Sillustaniidae. Crochet and Sigé (1993) preliminary assumed that Sillustania was probably a caenolestoid paucituberculatan, but in their formal description they recognized the Sillustaniidae as a new family belonging to the polydolopoid polydolopimorphians. A review of the holotype and tentatively referred specimen of Sillustania quechuense led us to reassess its upper molar morphology and homologies, as well as its phylogenetic affinities. The discussion of these aspects constitutes the main purpose of this work.","palabras_clave":"South America|Perú|Paleogene|Paleocene|Sillustania|Polydolopimorphia|Polydolopiformes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":581,"idioma_id":4,"titulo":"Shorebird Seasonal Abundance and Habitat-use Patterns in Punta Rasa, Samborombón Bay, Argentina","resumen":"Shorebird assemblage composition and habitat-use patterns were characterized at Punta Rasa during the austral summer, autumn and winter. Compared to other sites within the region, this area showed high species richness, reflected by a total of 22 species recorded within a relatively short time frame. Differences in assemblage structure were driven by the use of estuarine mudflats and oceanic sandy beaches as feeding habitats. During low tide, more species used estuarine environments, achieving the highest total densities. Abundance patterns and assemblage composition also changed seasonally. Maximum total abundance occurred during the austral summer, and minimum total abundance during the austral winter. During the austral summer, the assemblage was dominated by Nearctic migrants such as American Golden-Plover (Pluvialis dominica), Hudsonian Godwit (Limosa haemastica) and White-rumped Sandpiper (Calidris fuscicollis). In addition, Two-banded Plover (Charadrius falklandicus) and American Oystercatcher (Haematopus palliatus) were abundant during the austral autumn. The Red Knot (Calidris canutus), a shorebird that dominated the austral autumn assemblage 25 years ago, was recorded in relatively small numbers during this study, probably reflecting the global population trend of a subspecies of the Red Knot (C. c. rufa) in the past two decades. During the austral winter, resident birds largely dominated the assemblage. However, it is noteworthy that some individuals of nine Nearctic migrant species remained in the area. In the case of the endangered Red Knot, Punta Rasa is, along with Lagoa do Peixe in Brazil, one of the sites in South America with the highest known abundances during the austral winter. .","palabras_clave":"Argentina|migration|shorebirds|Samborombon bay"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":582,"idioma_id":5,"titulo":"El Pucará de Perchel (Dpto. Tilcara, Jujuy, Argentina): Un lugar estratégico en el sector central de la Quebrada de Humahuaca","resumen":"En este trabajo se analiza la configuración espacial del Pucara de Perchel y las características de su emplazamiento. El Pucara de Perchel es un sitio de 2.921 m2 de superficie, ubicado en el Angosto de Perchel (Dto. Tilcara, Prov. de Jujuy, Argentina) que habría sido ocupado con mayor intensidad durante los períodos Intermedio Tardío e Inca. Se plantean hipótesis acerca del rol del Pucara de Perchel en el paisaje social del sector medio de la Quebrada de Humahuaca, y también acerca de su cronología. Asimismo, se busca contrastar la hipótesis propuesta a partir de documentos del siglo XVII, según la cual el Pucara de Perchel correspondería a la frontera norte del territorio de Tilcara, entidad política que ocupaba el sector central de la Quebrada a la llegada de los españoles. El análisis realizado permitió considerar que el Pucara de Perchel habría funcionado como un pucara durante el período Intermedio Tardío, constituyéndose probablemente como un espacio fronterizo. Su rol como un lugar estratégico se extendería en el tiempo, siendo un lugar de importancia durante las guerras de la independencia del siglo XIX.","palabras_clave":"QUEBRADA DE HUMAHUACA|PUCARA DE PERCHEL|DELIMITACION TERRITORIAL|PUCARA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":588,"idioma_id":4,"titulo":"Nitric oxide-mediated cell death is triggered by chitosan in F. eumartii spores","resumen":"The genus Fusarium comprises a heterogeneous group of fungi important for    agriculture. Fusarium solanif. sp.  eumartii(F. eumartii) historically considered a fungal pathogen of potato has been also associated with tomato disease. Currently, chitosan and its derivatives have been getting more attention as environmental friendly antimicrobial compound  in sustainable practices. The aim of this work was  to characterize ownstream events associated to the mode of action of chitosan including nitrosative reactive species in order to identify new biomarkers of its cytotoxic action.   RESULTS: Our data indicated that chitosan-mediated  NO production might lead to conidial death, concomitant with the strong reduction of fungal pathogenicity in tomato plants. Following chitosan applications, a notably dose-dependent reduction of the conidial viability was demonstrated in  F. eumartii.Thereafter, the infectivity of chitosan-treated spores was tested by a bioassay using tomato seedlings.  CONCLUSION: All these data confers NO valuable properties as a quantitative and qualitative  biomarker of cytotoxic action of chitosan in conidial cells. In addition, these findings place the chitosan here assayed, as a fungicide with a high potential of application in sustainable horticultural practices.","palabras_clave":"CHITOSAN|FUNGICIDE|NITRIC OXIDE|FUSARIUM SOLANI F.SP. EUMARTII"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":590,"idioma_id":4,"titulo":"Probable prostate cancer in a Pre-Incaic individual from Pukara de la Cueva, Nortwestern Argentina.","resumen":"Prostate carcinoma is a common malignant neoplasia that mostly metastasizes to bone in males. Nonetheless, the number of paleopathological cases reported is very small. Most of them were identified in Europe, and only two came from South American individuals. The purpose of this paper is to document the lesions identified in a Pre-Columbian (around 1400 AD) individual that corresponds to a middle adult male from Pukara de la Cueva, Jujuy province, in the Northwest region of Argentina. The skeleton was found disarticulated but it is nearly complete and well preserved. The general character of the lesions observed is predominantly proliferative in nature, but osteolytic and mixed patterns were also detected in both axial and appendicular skeleton. Macroscopically, this overall pattern and the distribution of the lesions are compatible with a secondary cancer. Radiological examination showed multiple dense and irregular areas in several bones. The lesions visible by external inspection and by radiographs are in concordance with changes which are documented to occur in the course of prostatic carcinoma. The exuberance and dissemination of the lesions all over the skeleton led infer individual cachexy implying that he would have been assisted by his family and\/or social group during the chronic process. Different carcinogenic risk factors associated to this kind of disease are discussed. This analysis adds new evidence of Pre-Columbian carcinoma in South American native populations, as knowledge from clinical cases  is considered to delineate a differential diagnosis.","palabras_clave":"Bioarchaeology|Paleopathology|prostatic cancer|Pre-inka period"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":594,"idioma_id":4,"titulo":"The first record of the chimaeroid genus Edaphodon (Chondrichthyes, Holocephali) from Antarctica (Snow Hill Island Formation, Late Cretaceous, James Ross Island)","resumen":"A new species of an edaphodontid holocephalian, Edaphodon snowhillensis, sp. nov., is described based on a complete dentition collected in the late Campanian Herbert Sound Member of the Snow Hill Island Formation of James Ross Island, Antarctica. The dentition consists of paired vomerine, mandibular, and palatine tooth plates, which are almostcompletely preserved. The new species is characterized by a unique character combination out of which the presence of a subquadrangular vomerine tooth plate and a horse-hoof-shaped anterior outer tritor in the mandibular tooth plates appear to be unique characters among the edaphodontids. Edaphodon snowhillensis, sp. nov., represents the most complete dentition of a holocephalian fish from the Southern Hemisphere and the earliest record of the genus Edaphodon from the Antarctic continent and the Weddellian Biogeographic Province. Also, E. snowhillensis, sp. nov., is the southernmost specimen of this genus and according to the size of the tooth plates is one of the largest chimaeroid fish known.","palabras_clave":"CHIMAEROID|LATE CRETACEOUS|ANTARCTICA|EDAPHODON"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":601,"idioma_id":4,"titulo":"Influence of the winter phytoplankton bloom on the settled material in a temperate shallow estuary","resumen":"The development of the phytoplankton winter bloom and the accumulation of particulate suspended matter (PSM) inside sediment collectors were assessed in the inner zone of the Bahía Blanca Estuary. The phytoplankton bloom (chlorophyll up to 25 mg l1 and abundance up to 8  106 cells l1) was related with high levels of dissolved inorganic nutrients and underwater light availability (Im up to 355 mE m2 s1) and was dominated by relatively small diatoms, e.g. Chaetoceros sp.1 (3?8 mm). Conversely, large planktonic diatoms, mostly Thalassiosira spp. 20?60 mm, were found in the accumulated material inside the collectors, together with benthic microalgae and high concentrations of chlorophyll, phaeopigments, particulate organic matter (POM between 18 and 32% of total PSM) and C:N ratios &gt;12. The composition of the settled material indicated vertical exportation of phytoplankton to the benthos, external loads of detritus and bottom resuspension. The present study highlights the close benthic?pelagic interactions in shallow coastal environments characterized by high productivity.","palabras_clave":"sediment trap|phytoplankton bloom|benthic-pelagic interactions|shallow estuary"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":602,"idioma_id":4,"titulo":"Evaluation and improvement of the ecogeographical representativeness of a collection of the genus Trichloris in Argentina","resumen":"In Argentina, species of the genus&nbsp;Trichloris&nbsp;represent an important native forage resource adapted to drought and salinity. The capture and identification of adaptive traits associated with such conditions require long-term collection and characterization efforts. Ecogeographical land characterization (ELC) maps constitute an easy and useful tool to evaluate ecogeographical representativeness in established collections, allowing for the design of new collecting strategies. In the present study, an ELC map was generated from ecogeographical variables closely associated with the adaptation of the target species. For each ELC map category, the accessions preserved at the&nbsp;Trichloris&nbsp;genebank of the Facultad de Ciencias Agrarias-Universidad Nacional del Litoral were compared with external presence data. After the identification of the ecogeographical gap, a collecting expedition was designed. Collecting indices showed a significant improvement in the ecogeographical representativeness of the collection to the extent that accessions had a high probability of containing abiotic adaptation genes. The results emphasize the usefulness of ELC maps and the importance of planning collections through ecogeographical approaches","palabras_clave":"COLLECTING STRATEGIES|ELC MAPS|GERMOPLASM|NATIVE PLANT GENETIC RESOURCES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":603,"idioma_id":4,"titulo":"External pressure induced buckling collapse of high density polyethylene (HDPE) liners: FEM  modeling and predictions","resumen":"Thermoplastic polymers such as HDPE are nowadays widely used as lining materials for oil and gas pipelines. However, during maintenance or unexpected service stoppages, these liners can undergo external pressure induced bucking collapse. The objective of this work is to assess the mechanical response of HDPE liners undergoing buckling collapse by means of Finite element modeling (FEM) simulations on Abaqus 6.10. To accomplish this, an advanced constitutive model, namely the Three Network Model (TNM) was employed. In order to determine the input parameters for the model, a series of tensile and compressive uniaxial tests were conducted. The suitability of the model for this particular application was assessed by contrasting the simulation and the experimental results of a diametral compression test. The complex strain rate and pressure dependent mechanical response of HDPE liners was analyzed by modeling the buckling collapse dynamic event as an increasing volume of fluid entering the gap cavity between liner and host pipe. The model predictions allowed establishing a mathematical relationship between the depressurization velocity of the tubes and the resulting collapse pressure. These relations can be used to improve the current design guidelines for plastic liners.","palabras_clave":"Buckling collapse|Constitutive modeling|HDPE liners|Finite element modeling"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":606,"idioma_id":4,"titulo":"Diel patterns of total suspended solids, turbidity, and water transparency in a highly turbid, shallow lake (Laguna Chascomús, Argentina)","resumen":"The effects of external physical forcing variables (solar radiation and winds) on short-term dynamics of total suspended solids (TSS), Chlorophyll- a (Chl-a), turbidity levels, and water transparency were studied during 15 days in a highly turbid, shallow lake (Laguna Chascomu´ s, Argentina). Water samples were taken three times per day (8, 14 and 20 h.). Solar radiation and wind velocity showed a repeatedly bell-shaped diurnal pattern, with significant higher values during morning and afternoon, respectively.TSS and turbidity displayed a general decreasing trend during the sampling period, while water transparency showed the opposite trend. Also Chla displayed a decreasing trend and was closely correlated to TSS levels. We assayed a first-order kinetics model to detrend the series, obtaining the rate of change during the night, morning, and afternoon. We observed higher values on afternoon compared to morning for TSS, Chl-a, and turbidity levels and the opposite pattern for water transparency. We conclude that this pattern may result from a combination of biological activity, as it took place after a period of intense photosynthetic activity, together with resuspension by winds during the afternoon, (windiest time of the day).","palabras_clave":"Shallow turbid lake|Physical forcing|Total suspended solids|Turbidity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":612,"idioma_id":4,"titulo":"Niche segregation facilitates coexistence between native and introduced fishes in a deep Patagonian lake","resumen":"Species introductions force sympatry between species that did not coevolve.  Introduced salmonids have coexisted with native fish since the early 20th  century in Patagonian water bodies, thus generating questions about the mechanisms thatfacilitate their coexistence. We analyzed the trophic and spatial intra- and inter-specific relationships established among native and salmonid species in a deep oligotrophic lake of Patagonia in order to determine niche partitioning patterns as strategies for their coexistence. Salmonids were more generalist feeders, while native species had narrower trophic niches. Native fish and introduced salmonids partitioned food, mainly through the consumption of the crayfish Samastacus sp. and the native galaxiid Galaxias maculatus, respectively. The diet of most species changed with body size, shifting from insects\/amphipods to the larger G. maculatus and crayfish. Trophic interactions varied with season, in association with prey seasonality. In general, fish  feeding on the same prey were captured in the same depth strata, indicating common use of food and space. Our results provide new evidence on the trophic ecology of a mixed fish community (exotic-native), supporting the idea that native and non-native fishes could be avoiding negative interactions (e.g., competition) through trophic and spatial resource partitioning.","palabras_clave":"RESOURCE PARTITIONING|FISH INTRODUCTION|NON-NATIVE SALMONIDS|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":619,"idioma_id":4,"titulo":"SASP, a Senescence-Associated Subtilisin Protease, is involved in reproductive development and determination of silique number in Arabidopsis","resumen":"Senescence involves increased expression of proteases, which may participate in nitrogen recycling or cellular signalling. 2D zymograms detected two protein species with increased proteolytic activity in senescing leaves of Arabidopsis thaliana. A proteomic analysis revealed that both protein species correspond to a subtilisin protease encoded by At3g14067, termed Senescence-Associated Subtilisin Protease (SASP). SASP mRNA levels and enzyme activity increase during leaf senescence in leaves senescing during both the vegetative or the reproductive phase of the plant life cycle, but this increase is more pronounced in reproductive plants. SASP is expressed in all aboveground organs, but not in roots. Putative AtSASP orthologues were identified in dicot and monocot crop species. A phylogenetic analysis shows AtSASP and its putative orthologues clustering in one discrete group of subtilisin proteases in which no other Arabidospsis subtilisin protease is present. Phenotypic analysis of two knockout lines for SASP showed that mutant plants develop more inflorescence branches during reproductive development. Both AtSASP and its putative rice orthologue (OsSASP) were constitutively expressed in sasp-1 to complement the mutantphenotype. At maturity, sasp-1 plants produced 25% more inflorescence branches and siliques than either the wildtype or the rescued lines. These differences were mostly due to an increased number of second and third order branches. The increased number of siliques was compensated for by a small decrease (5.0%) in seed size. SASP downregulates branching and silique production during monocarpic senescence, and its function is at least partially conserved between Arabidopsis and rice.","palabras_clave":"At3g14067|inflorescence|protease activity|reproductive development|senescence|subtilisin protease"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":621,"idioma_id":4,"titulo":"Combustion Syntheses of CoAl2O4 Powders Using Different Fuels","resumen":"Co3O4 powders are used as pigment in solar selective paints. In this work, two new gel-combustion processes for the synthesis of  Co3O4 nanopowders with lysine (Lys) or ethylenediaminetetraacetic acid (Edta) as fuel are presented. The first route is a  conventional, stoichiometric process, while the second one is a non-stoichiometric, pH-controlled process. The samples were  calcined in air at 500 ºC. They were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM),  transmission electron microscopy (TEM), Fourier transform infrared spectrum (FTIR), Thermogravimetric analysis (TGA) and  differential scanning calorimetry (DSC) and the optical properties of the pigments were assessed with a spectrophotometer. In all  cases, powders exhibited the Co3O4 crystalline structure. A minimum crystallite average size of 19 nm for powders obtained by  the ?stoichiometric\/Lys? combustion route was observed, meanwhile, a maximum value of 47 nm was stated for powders  obtained by the ?non-stoichiometric\/Edta? combustion process. The average particle size ranged between 50 and 100 nm. The  powders obtained by the stoichiometric nitrate?lysine route were selected to study its optical properties, their solar absorption  was 88%, compared with the references, evidencing their aptitude to be used in solar absorbent paints.","palabras_clave":"Sintesis por gelificacion comustion |pinturas selectivas |aprovechamiento solar"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":630,"idioma_id":5,"titulo":"Germinación de Eryngium regnellii: especie clave para la restauración ecológica de las interacciones planta-polinizador en la Pampa Austral (Buenos Aires, Argentina)","resumen":"Eryngium regnellii Malme pertenece al género más amplio dentro de la familia Apiaceae, con 250 especies en todo el mundo y 65 representadas en América del Sur. Es una especie herbácea típica de las comunidades vegetales serranas, que junto con los remanentes de pastizales, constituyen los hábitats naturales más relevantes para el sostenimiento de la diversidad en la Pampa Austral. Eryngium regnellii es clave para el mantenimiento del mutualismo de polinización, por ser una especie generalista (exhibe un elenco diverso de polinizadores) y ubicua (presente en todas las sierras estudiadas). Sin embargo, la fragmentación del paisaje Pampeano debido a la intensificación agrícola ha generado la pérdida de muchos de estos ambientes naturales, por lo que la reintroducción de E. regnellii en lugares estratégicos facilitaría la presencia de polinizadores silvestres y el servicio de polinización en el agroecosistema. Dado que un mayor conocimiento sobre la biología reproductiva de la especie brindaría información relevante para su reproducción y reintroducción en áreas degradadas, se estudiaron los requerimientos germinativos de E. regnellii. Se evaluó el porcentaje de germinación y el tiempo medio de germinación de un control y de dos tratamientos pre-germinativos: escarificación química con ácido sulfúrico y escarificación mecánica con lija. Las semillas escarificadas químicamente no germinaron, mientras que las escarificadas mecánicamente y el control no presentaron diferencias significativas en los porcentaje de germinación (49% y 59%, respectivamente) ni en el tiempo medio de germinación (13 y 14 días respectivamente). Los resultados indican que, bajo las condiciones de laboratorio empleadas, E. regnellii no presenta dormancia física y por lo tanto no necesita tratamientos pre-germinativos específicos para germinar. La relativamente alta capacidad germinativa de E. regnellii, junto con sus atributos ecológicos, la convierten en una especie potencial para su utilización en la restauración de las interacciones planta-polinizador en el paisaje fragmentado de la Pampa Austral.","palabras_clave":"Apiaceae|Eryngium regnellii|escarificación|requerimientos germinativos|mutualismo de polinización"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":635,"idioma_id":4,"titulo":"Electrical behavior analysis of n-type CaCu3Ti4O12 thick films exposed to different atmospheres","resumen":"In this work n-type CaCu3Ti4O12 (CCTO) thick films obtained by screen printing were studied. The role of the potential barrier characteristics  (height and width) was considered in order to explain the electrical behavior. The electrical response was also analyzed considering the oxygen  adsorption and subsequent diffusion into the grains at temperatures higher than 280 C. Tunnel currents were also calculated taking into account  the donor concentration values for films in vacuum atmosphere.","palabras_clave":"Semiconductor|Conduction mechanism|CaCu3Ti4O12|Diffusion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":639,"idioma_id":4,"titulo":"Impact of freeze-thaw treatment on the stability of calcium-fortified soy beverages","resumen":"The objective was to study the freeze-thaw stability of soy beverages (SB) obtained from active defatted soy flour and fortified with calcium at the level of bovine milk. Calcium chloride or calcium lactate was used to fortify the SB, and a third sample without calcium was prepared as control. Sunflower oil was added as lipid phase and high pressure homogenization was performed to obtain the systems. SB were prepared without or with sucrose (5.0 and 10.0 g\/100g) as cryoprotectant. In the absence of sucrose, freeze-thawing produced important aggregation of particles, observing a higher particle size increase (PSI) after 30 days of frozen storage in both SB with calcium (~700) than without addition of the cation (~500). Only the SB with 10.0 g\/100 g sucrose presented an acceptable stability to freeze-thawing, and at that concentration of cryoprotectant the systems with calcium showed a lower PSI (~30) than in the absence of the cation (~100). In this case, because initial protein aggregation was favored in presence of calcium, new aggregation might have been limited during frozen storage at the conditions given by the cryoprotectant. The apparent viscosity of the samples decreased after freeze-thawing, probably because of the dehydration and compaction of aggregates.","palabras_clave":"CALCIUM|FREEZE-THAWING|HIGH PRESSURE HOMOGENIZATION|SOYBEAN FLAKES|SOY BEVERAGES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":641,"idioma_id":4,"titulo":"Development of a highly sensitive noncompetitive electrochemical immunosensor for the detection of atrazine by phage anti-immunocomplex assay","resumen":"    The development of  immunosensors for the detection of small molecules is of great interest because  of their simplicity, high sensitivity and extended analytical range. Due to  their size, small compounds cannot be simultaneously recognized by two  antibodies impeding their detection by noncompetitive two-site immunoassays,  which are superior to competitive ones in terms of sensitivity, kinetics, and  working range. In this work, we combine the advantages of magneto-electrochemical  immunosensors with the improved sensitivity and direct proportional signal of noncompetitive  immunoassays to develop a new Phage Anti-Immunocomplex Electrochemical Immunosensor  (PhAIEI) for the detection of the herbicide atrazine. The noncompetitive assay  is based on the use of recombinant M13 phage particles bearing a peptide that  specifically recognizes the immunocomplex of atrazine with an anti-atrazine  monoclonal antibody. The PhAIEI performed with a limit of detection (LOD) of  0.2 pg mL-1, which is 900-fold better than the LOD obtained using  the same antibody in an optimized conventional competitive ELISA, with a large  increase in working range. The developed PhAIEI was successfully used to assay undiluted  river water samples with no pretreatment and excellent recoveries. Apart from  the first demonstration of the benefits of integrating phage anti-immunocomplex  particles into electrochemical immunosensors, the extremely low and  environmentally relevant detection limits of atrazine attained with the PhAEIS  may have direct applicability to fast and sensitive detection of this herbicide  in the environment.  ","palabras_clave":"ANTI-IMMUNOCOMPLEXPEPTIDE|IMMUNOSENSOR|ATRAZINE|CHRONOAMPEROMETRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":642,"idioma_id":4,"titulo":"Studies of the electrochemical behavior of moniliformin mycotoxin and its sensitive determination at pretreated glassy carbon electrodes in a non-aqueous medium","resumen":"      The electrochemical oxidation of  moniliformin (MON) mycotoxin in acetonitrile (ACN) + 0.1 mol dm-3 (C4H9)4NPF6  at electrochemically pretreated glassy carbon electrodes (EPGCE) and fiber disk  carbon ultramicroelectrodes (FCUME) is studied for the first time. Electrochemical  techniques used were cyclic (CV), convolution and square wave (SWV)  voltammetries as well as controlled potential electrolysis. Experimental  results allowed inferring a complex electro-oxidation mechanism with adsorption  of reactant and homogeneous chemical steps coupled to the electron transfer  reaction.       The UV-Vis spectroscopy was used  as a non-electrochemical technique in order to follow the disappearance\/appearance of the  reactant\/reaction product\/s during controlled potential electrolysis.      The most probable electro-oxidation  mechanism proposed on the base of digital simulation results of cyclic  voltammograms is one of the CEC type. Thermodynamic and kinetics parameters  were calculated from the fitting of experimental cyclic voltammograms, while  the diffusion parameter was calculated from convoluted cyclic voltammograms. We  propose that reaction products obtained are produced through the decomposition  of the MON radical generated from the electrochemical oxidation of MON anion.      On the other hand, the MON  quantitative determination was performed using adsorptive SWV at EPGCE. An  extremely low detection limit of 1 x 10-11 mol dm-3 (1.2  ppt) for a signal to noise ratio of 3:1 was calculated.   ","palabras_clave":"MONILIFORMIN|ELECTROCHEMICAL OXIDATION|CYCLIC VOLTAMMETRY|SQUARE WAVE VOLTAMMETRY|THERMODYNAMICS AND KINETICS PARAMETERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":645,"idioma_id":4,"titulo":"Modeling concrete like materials under sever dynamic pressures","resumen":"The behavior of concrete, as well as that of all cohesive-frictional materials, is characterized by a strong dependence on hydrostatic pressure and strain rate sensitivity. The stressestrain response is nonlinear and, depending on the loading path, it can show compaction and dilatancy. Due to its internal constitution, the numerical simulation of this type of materials can be done with a great variety of approaches which are mainly differentiated by the modeling scales and the approximation methods used. Appropriate formulation and calibration of the models are necessary to accurately reproduce the physical phenomena involved in the simulated processes. A general elasticeviscoplastic model for concrete like materials under high strain rate dynamic loads that produce high confinement pressures, like those present in blast actions, is presented in this paper. The model developed is of phenomenological type and it is formulated within the framework of continuum thermodynamics for irreversible processes with internal variables and small strains. Nonassociated plastic flow, cap function and hardening functions that depend on the loading path are proposed. The transition between compaction and dilatancy processes observed in triaxial compression experimental tests can be properly reproduced with the non-associated flow consideration and the proposed hardening functions. The cap function allows the appropriate simulation of the materialvolumetric response for high confinement pressures. The model formulation is general and it can be used for other cohesive-frictional materials.The numerical integration algorithm is implemented in a 2D finite element dynamic program that allows solving nonlinear problems of solid mechanics in small strains.For the model validation, static and dynamic tests with different loading paths and confinement levels for many types of concretes and mortars are analyzed. Numerical results are compared with experimental results obtaining a good description of the main characteristics of this type of materials response under high strain rate pressures.","palabras_clave":"CONCRETE|CONSTITUTIVE MODEL|STRAIN RATE|CONFINENMENT|COMPACTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":654,"idioma_id":4,"titulo":"Treatment in vitro with PPAR-alpha and PPAR-gamma ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice","resumen":"Trypanosoma cruzi, the etiological agent of Chagas´ disease, induces a persistent inflammatory response. Macrophages are a first line cell phenotype involved in the clearance of infection. Upon parasite uptake, these cells increase inflammatory mediators like NO, TNF-&#945;, IL-1&#946; and IL-6, leading to parasite killing. Although desired, inflammatory response perpetuation and exacerbation may lead to tissue damage. Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent nuclear transcription factors that, besides regulating lipid and carbohydrate metabolism, have a significant anti-inflammatory effect. This is mediated through the interaction of the receptors with their ligands. PPAR&#947;, one of the PPAR isoforms, has been implicated in macrophage polarization from M1, the classically activated phenotype, to M2, the alternatively activated phenotype, in different models of metabolic disorders and infection. In this study, we show for the first time that, besides PPAR&#947;, PPAR&#945; is also involved in the in vitro polarization of macrophages isolated from T. cruzi-infected mice. Polarization was evidenced by a decrease in the expression of NOS2 and proinflammatory cytokines and the increase in M2 markers like Arginase I, Ym1, mannose receptor and TGF-&#946;. Besides, macrophage phagocytic activity was significantly enhanced, leading to increased parasite load. We suggest that modulation of the inflammatory response by both PPARs might be due, at least in part, to a change in the profile of inflammatory macrophages. The potential use of PPAR agonists as modulators of overt inflammatory response during the course of Chagas´ disease deserves further investigation.","palabras_clave":"Tripanosoma Cruzi|PPAR alfa y gama|macrofagos|polarizacion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":656,"idioma_id":4,"titulo":"Spatial genetic structure of dusky dolphin, Lagenorhynchus obscurus, along the argentine coast: preserve what scale?","resumen":"1. The dusky dolphin (Lagenorhynchus obscurus) represents one of the most abundant species of small cetacean in Argentine waters. During the 1980s and 1990s, high levels of incidental mortality in purse and trawl &#64257;sheries were documented, and in recent decades tourism activities have been added as a   potential source of disturbance.  2. The study objectives were to identify spatial genetic structure and regional genetic patterns of dusky dolphins along the Argentine coast. The variation of 413bp of the control region of 119 individuals over six locations spread along 2800 km (38°40?S to 54°30?S) was examined. Spatial genetic analyses, SAMOVA, genetic landscape shapes and autocorrelation analyses were conducted.  3. The most probable con&#64257;guration was K=2, island population vs. continental populations (FCT = 0.774) and the spatial autocorrelation analysis showed a strong regional genetic structure, de&#64257;ning an operational unit at < 50 km.  4. The results provide valuable information that should be taken into account in the development of conservation strategies and management of the species; making the efforts focus on conserving vulnerable dusky dolphin groups by protecting their preferred coastal shallow habitat and by monitoring and regulating the dolphin watching and &#64257;shing activities, acting upon local populations along the Argentine coast.","palabras_clave":"coastal dusky dolphins|marine mammals|landscape genetics|conservation evaluation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":665,"idioma_id":5,"titulo":"Organización social y asentamientos intermedio tardíos en el Valle de Santa María: problemas y vías de análisis","resumen":"El  tema de la organización social de las poblaciones antiguas tiene un rol central  en la arqueología de asentamientos. Nos proponemos en este trabajo examinar de  qué manera los postulados teóricos acerca de la organización de sociedades  pre-capitalistas pueden ser articulados con la evidencia empírica del Período  Intermedio Tardío del valle de Santa María. Tomamos de la bibliografía teórica  dos aspectos específicos -jerarquías de asentamiento y segregación residencial-  a los fines de explorar los desafíos y problemas que enfrenta su estudio  empírico. Ejemplificamos para esto con casos de la Sierra del Cajón (provincias  de Catamarca y Tucumán), observando, por un lado la estrecha relación de las  jerarquías de asentamiento con los patrones de asentamiento y las áreas de  captación; y por otro lado la necesidad de  desarrollo de observaciones detalladas de la arquitectura, en lo que respecta a  la evaluación acerca de la existencia de segregación residencial.","palabras_clave":"ORGANIZACIÓN SOCIAL|ARQUEOLOGÍA DE ASENTAMIENTOS|VALLE DE SANTA MARÍA|PERÍODO INTERMEDIO TARDÍO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":695,"idioma_id":4,"titulo":"New examples of asymptotically good Kummer type towers","resumen":"In this work, we give sufficient conditions in order to have finite ramification locus in sequences of function fields defined by different kind of Kummer extensions. These conditions can be easily implemented in a computer to generate several examples. We present some new examples of asymptotically good towers of Kummer type and we show that many known examples can be obtained from our general results.","palabras_clave":"Function fields|Kummer extensions|Towers"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":696,"idioma_id":5,"titulo":"Estudios sobre cooperación en perros domésticos: Una revisión crítica","resumen":"El estudio comparado de la cooperación contribuye al entendimiento de sus orígenes evolutivos y mecanismos próximos. Esta revisión se centra en estudios sobre cooperación en perros domésticos. Para ello definimos conceptos relacionados a la cooperación. Describimos las razones filogenéticas y ontogenéticas que hacen del perro un buen modelo para el estudio de la cooperación y hacemos una revisión crítica de los trabajos realizados en este campo. Incluimos investigaciones sobre situaciones cooperativas así como sobre las habilidades cognitivas involucradas. Finalmente discutimos hipótesis sobre los mecanismos próximos de esta habilidad que incluyen elementos emocionales, motivacionales y de aprendizaje asociativo.","palabras_clave":"Cooperación|Reciprocidad|Psicología Comparada|Cognición Social"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":700,"idioma_id":4,"titulo":"Climate changes and solar cycles recorded at the Holocene Paraná Delta, and their impact on human population","resumen":"The Paraná delta, growing at a rate of c. 2 km2 yr-1 since 6,000 yrs, is one of the most complete record of late Holocene in southern South America. The evolution of this 17,400 km2 delta enclosed in Plata estuary, can be tracked by a series of 343 successive coastal-ridge showing a c.11 years period, in coincidence with sunspot cycle, also found in some North Hemisphere coastal-ridge successions. The Paraná delta shifted from fluvial, to wave-dominated, and back to the present fluvial dominated delta, in response to climate changes associated with wind activity correlating with South American glacial cycles. The wave-dominated windy period coincides with activation of the Pampean Sand Sea, suggesting desert conditions prevailed on the Pampas between 5,300 and 1,700 yrs, in coincidence with scarce or absent pre-historic aborigine remains (archeological silence). Further warmer and less windy conditions allowed human repopulation. Results suggest that aside the solar forcing, both short and medium term climate changes controlled delta evolution. An important learning is that a slight cooling would turn the highly productive pampas, into that unproductive desert and, given the lack of artificial irrigation systems, changing present-day warmhouse into a cooling cycle might be economically catastrophic for the region.","palabras_clave":"Holocene|Parana river delta|South America|climatic changes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":706,"idioma_id":4,"titulo":"Capillary Electrophoretic Determination of Fluoroquinolones in Bovine Milk Followed by Off-Line MALDI-TOF-MS Analysis","resumen":"A novel appro ach for the determination of ciprofloxacin, norfloxacin and ofloxacin by capillary electrophoresis and off-line capillary electrophoresis?matrix-assisted laser desorption\/ionization-time of flight-mass spectrometry coupling for the confirmation of analyte identities is presented. A polymer capillary coating was proposed with the aim to minimize suppression of the MS signal caused by the CE solution components. The fluoroquinolones were successfully separated and determined by CE-UV followed by fractionation onto a MALDI plate and off-line MS characterization. Full-cream and low-fat milk samples were used to illustrate that the proposed method represents an efficient alternative for fluoroquinolone antibiotics determination in milk.","palabras_clave":"Capillary electrophoresis|Matrix-assisted laser desorption\/ionization mass spectrometry|Fluoroquinolones|Off-line integration"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":709,"idioma_id":4,"titulo":"An hp finite element adaptive scheme to solve the Poisson problem on curved domains","resumen":"In this work, we introduce an hp finite element method for two-dimensional Poisson problems on curved domains using curved elements. We obtain a priori error estimates and define a local a posteriori error estimator of residual type. We show, under appropriate  assumptions about the curved domain, the global reliability and the local efficiency of the estimator. More precisely, we prove that the estimator is equivalent to the energy norm of the  error up to higher-order terms. The equivalence constant of the efficiency estimate depends on the polynomial degree. We also present an hp adaptive algorithm and several numerical  tests which show the performance of the adaptive strategy.","palabras_clave":"elementos finitos|dominios curvos|adaptividad hp|Problema de Poisson"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":724,"idioma_id":5,"titulo":"La investigación sobre clases populares, acción colectiva y proceso político en la Argentina. De la configuración de dos matrices de análisis a la incorporación de nuevos desafíos","resumen":"Este artículo examina las características teóricas y metodológicas de las dos perspectivas de investigación más utilizadas en la Argentina para estudiar las relaciones entre clases populares, acción colectiva y proceso político. Sostiene que existe una doble matriz de análisis basada en la sociología política y la etnografía política respectivamente. Además, aborda los desafíos que encuentra la aplicación de estas perspectivas a partir de los cambios políticos y sociales introducidos a partir del año 2003.","palabras_clave":"Clases Populares|Acción Colectiva"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":736,"idioma_id":4,"titulo":"Pasteurization conditions and evaluation of quality parameters of frozen packaged crab meat","resumen":"Ovalipes trimaculatus is a crab recognized as a new resource with fishing value to obtain frozen products. Pasteurization conditions of meat crab at temperatures below 85ºC (60, 72 y 82ºC) were established to achieve better quality attributes in the frozen product. The lethality curves of Staphylococcus aureus and Listeria monocytogenes were measured, and the decimal reduction times (D) and Z values were determined. Heat transfer during the pasteurization process of pouches containing crab meat were simulated using a computational code in finite elements, and the mathematical model was experimentally validated. Thermal histories were coupled to the microbial lethality kinetics of the most heat resistant pathogen microorganism in order to establish pasteurization times necessary for the process system design. The predicted pasteurization conditions were microbiologically validated. The pouches were frozen under industrial conditions and stored at -22ºC for one year. The influence of the type of packaging (vacuum and non-vacuum plastic pouches) on physicochemical and sensory quality parameters of frozen crab meat (color, exudate, lipid oxidation, water holding capacity, and overall acceptability) were analyzed observing better performance under vacuum conditions","palabras_clave":"crabs|pasteurization|Staphylococcus aureus,|vacuum packaging"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":741,"idioma_id":4,"titulo":"The interaction of heavy metals and nutrients present in soil and native plants with arbuscular mycorrhizae on the riverside in the Matanza-Riachuelo River Basin (Argentina)","resumen":"This study assessed the contamination by heavy metals (Cr, Cu, Pb, Zn), and nutrients (N, P) in soils and native  plants, and the effect of the concentration of those elements with the density of arbuscular-mycorrhizal (AM)  spores in soil and colonization in roots from the riverside of the Matanza-Riachuelo River Basin (MRRB). The concentration of metals and nutrients in soils and plants (Eleocharis montana, Cyperus eragrostis, Hydrocotyle  bonariensis) increased from the upper sites (8 km from headwaters) to the lower sites (6 km from the mouth  of the Riachuelo River) of the basin. AM-colonization on the roots ofH. bonariensisand spore density in soil decreased as the concentrations of metals in soil and plant tissues increased from the upper to lower sites of the  basin within a consistent gradient of contamination associated with land use, soil disturbance, population, and  chemicals discharged into the streams and rivers along the MRRB. The general trends for all metals in plant tissue  were to have highest concentrations in roots, then in rhizomes and lowest in aerial biomass. The translocation  (TF) and bioconcentration (BCF) factors decreased in plants which grow from the upper sites to the lower sites  of the basin. The plants tolerated a wide range in type and quantity of contamination along the basin by concentrating more metals and nutrients in roots than in aboveground tissue. The AM spore density in soil and colonization in roots ofH. bonariensisdecreased with the increase of the degree of contamination (Dc) in soil","palabras_clave":"Riverside|Contamination gradient|Heavy metals|N and P|Arbuscular-mycorrhizae|Native plants"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":745,"idioma_id":4,"titulo":"cSi Photovoltaic Modules:  Main Degradation Factors","resumen":"1This paper presents the analysis of the power loss of a set of photovoltaic modules exposed for more than twelve years to solar radiation and environmental factors. This power loss is caused by various factors such as the loss of optical properties of the protective glass and the loss of transmittance of the encapsulant material (EVA), the increase of series resistance and the decrease in the parallel resistance as well as others not analyzed in this work. It will be obtained the percentage of the contribution of each of these in the total power loss.","palabras_clave":"DEGRADATION|SHUNT-SERIES|TRASMITANCE|LOSS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":747,"idioma_id":5,"titulo":"PARA MUESTRA BASTA UN BOTÓN (O DOS): UNA APROXIMACIÓN A LOS MARCOS CONCEPTUALES DE CTS DESDE LA INVESTIGACIÓN JURÍDICA","resumen":"A partir del análisis de la obra de Sheila Jasanoff se pretende, en este artículo, exponer  dos marcos conceptuales que pueden servir como insumo para trabajos de investigación  relativos a temáticas vinculadas al gobierno de los riesgos científicos y tecnológicos, y  el rol de los expertos.  En primer término se analiza la noción de co-producción. El mismo da cuenta de la  interrelación entre ciencia y política a la hora de la construcción del conocimiento como  así también en la toma de decisiones. En segundo lugar, se aborda la controversia que  genera la inclusión de expertos en los procesos judiciales y la confiabilidad de la prueba  por éstos aportada.  Este preliminar examen pretende poner en contacto la investigación jurídica con los  conceptos trabajados desde los estudios CTS.","palabras_clave":"CIENCIA TECNOLOGÍA Y SOCIEDAD|SHEILA JASANOFF|INVESTIGACIÓN LEGAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":748,"idioma_id":4,"titulo":". Influence of Information, Gender  and Emotional Status for Detecting Small Differences in the Acceptance of a New Healthy Beverage.","resumen":"Moderate wine consumption has been recommended as a health benefits practice, although alcohol content is sometimes the main factor for rejecting its consumption. This study focuses on the development of a fruit flavored powder beverage, having the same polyphenols of wine but without the alcohol content. The specific aim of the present work was to evaluate if the factors gender and information regarding health benefits could have some influence on consumer decisions while evaluating preference of samples with small formulation differences. In addition, emotional status and comments about likes and dislikes of the beverages were also investigated. For this purpose, one hundred and forty-four consumers (70 females and 74 males; aged 19 to 35 years old, M = 23.3, SD = 4.0) gave their degree of acceptance for four beverages. Each drink contained different levels of a powder concentrate of red wine (35 and 40 g\/L) and sweetener (4 and 5 g\/L). The participants estimated first by a 9-point category scale and, then by Visual Analogue Scales (VAS) the following attributes: acceptance, appearance, aroma, sweetness, flavor, acidity and astringency. Having two scales allowed the study to double check consumer evaluations. Results showed that the acceptance scores among formulations only showed significant differences with the 9-point category scale. The cross study presented the highest divergences by gender factor. Males gave similar or higher values when confirming the evaluation using the second scale. Conversely, females gave similar or lower values in the same conditions. Thus, the double scale strategy highlighted the differences of the target population. Even though information of health benefits did not increase the acceptance of the new beverage, it had a different impact between males and females. The emotions chosen by the consumers to describe their feelings about the new beverage helped to explain the acceptance data.","palabras_clave":"Emotions|Health|Wine| Drink powder"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":749,"idioma_id":4,"titulo":"Are rodents a source of biotic resistance to tree invasion in pampean  grasslands? Tree seed consumption under different conditions","resumen":"AbstractBiotic resistance has been invoked as a major barrier to woody species invasion,although the role of resident generalist consumers and their interaction with seedavailability in a local community have received little attention. We assessed tree seedconsumption by rodents under two different scenarios. 1- We documented in fieldspatio-temporal patterns of seed predation by native rodents on two exotic treespecies, Gleditsia triacanthos or 'honey locust' and Robinia pseudoacacia or 'white&nbsp;locust' (family Leguminosae), in five grassland habitats of the Inland Pampa,&nbsp;Argentina. 2- We conducted laboratory feeding trials to evaluate tree seed consumption&nbsp;in presence (cafeteria-style feeding trials) and in absence (non-choice feeding trials) of&nbsp;alternative food supplies. Seed predation was generally higher for Robinia than for&nbsp;Gleditsia seeds, both in field and laboratory conditions. For both tree species, seed&nbsp;predation varied between habitats and seasons and was higher in the native tussock&nbsp;grassland than in the remaining studied communities, whereas the crop field showed the&nbsp;lowest levels of consumption along with the absence of captured rodents. Seed&nbsp;consumption of Gleditsia and Robinia among the four grassland communities (which&nbsp;did not differ in rodent abundance) was negatively associated with the availability of&nbsp;alternative food. Laboratory feeding trials showed a higher consumption of Gleditsia&nbsp;seeds in the non-choice than in the cafeteria-style feeding trials, while the consumption&nbsp;of Robinia seeds did not differ in absence or presence of alternative seeds. These&nbsp;patterns indicate that the contribution of resident granivores to invasion resistance might&nbsp;depend on colonizer species identity, recipient community type and season of the year.&nbsp;We suggest that rodent preferences for different invader seeds will interact with the&nbsp;availability of alternative food in the local habitat in influencing the amount of predatormediated biotic resistance to invasion.Austral Ecology Page 2 of 45For Review Only","palabras_clave":"apparent mutualism| invasion,|biotic resistance| rodents, seed consumption."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":750,"idioma_id":4,"titulo":"Water quality assessment using multivariate statistical techniques in Río Tercero Reservoir, Argentina","resumen":"Water quality monitoring programs generate complex multidimensional data sets. In this study, multivariate statistical techniques were employed as an effective tool for the analysis and interpretation of these water quality data sets. Principal component analysis (PCA) and cluster analysis (CA) were applied to evaluate spatial and temporal variation of water quality in Río Tercero Reservoir (Argentina). Six sampling sites were surveyed each climatic season for 21 parameters during 2003-2010. The results revealed that PCA showed the existence of four significant principal components (PCs) which account for 96.7% of the total variance of the data set. The first PC was assigned to mineralization whereas the other PCs were built from variables indicative of pollution. Hierarchical CA grouped the six monitoring sites into three clusters and classified the different climatic seasons into two clusters based on similarities in water quality characteristics.","palabras_clave":"CLUSTER ANALYSIS|MONITORING|MULTIVARIATE STATISTICAL TECHNIQUES|PRINCIPAL COMPONENTS|SURFACE WATER|WATER QUALITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":760,"idioma_id":4,"titulo":"Prevalence of intestinal parasitic infection among children from a shanty town in Tucuman, Argentina","resumen":"A parasitological survey was conducted in children living in a poor area next to a drainagechannel, in Tucumán province, Argentina. Stool specimens from 115 children werecollected and samples were analyzed by direct microscopy examination and concentrationtechniques. The prevalence rate of intestinal parasites infection was high (78.3%) andBlastocystis hominis was the most frequent protozoan parasite found (68.9%) followed byGiardia intestinalis (33.3%), Entamoeba coli (24.4%), Endolimax nana (12.2%),Chilomastix mesnili (5.6%) and Iodamoeba bütschlii (2.2%). Ascaris lumbricoides was themost prevalent intestinal helminth, with an infection frequency of 38.9%, followed byTrichuris trichiura (13.3%), Strongyloides stercoralis (13.3%), Hymenolepis nana (7.8%)and Enterobius vermicularis (3.3%). Multiple parasitic infections were also high, affecting71.1% of infected population. These results indicate that sanitary policies, including healthcare and sanitary education have been inadequate for the control of intestinal parasitism inthis high-risk population. Implementation of sanitation programs is a basic need and a jointcollaboration between public servant and health professionals should be a priority.","palabras_clave":"INTESTINAL PARASITES|PROTOZOAN PARASITES|INTESTINAL HELMINTHS|RISK POPULATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":761,"idioma_id":4,"titulo":"Tumor location is a strong predictor of tumor progression and survival in T2 gallbladder cancer: an international multicenter study.","resumen":"Tumorlocation is a strong predictor of tumor progression and survival in T2gallbladder cancer: an international multicenter study.Shindoh J, de Aretxabala X, Aloia TA, Roa JC, Roa I, Zimmitti G,Javle M, Conrad C, Maru DM, Aoki T, Vigano L, Ribero D, Kokudo N, Capussotti L,Vauthey JN.Ann Surg. 2015 Apr;261(4):733-9. doi: 10.1097\/SLA.0000000000000728.","palabras_clave":"T2|Gallbladder cancer"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":772,"idioma_id":4,"titulo":"Dendritic zinc growth on the edges of flat steel strip during electro galvanizing","resumen":"Dendritic growth on strip edges during continuous zinc electroplating of flat steel strip for the automotive industry is a wellknown  problem. They produce surface defects during the stamping process. In this work the effect of the electrolytic process  variables on dendrites formation is studied. Zinc was electrodeposited on rotating steel discs. This new experimental  configuration reproduces the hydrodynamic conditions and the current distribution found on the strip edge in an industrial zinc  electroplating line. The tangential velocity of the outer edge of the discs was adjusted to a value equal to the relative speed  between strip and fluid used in the industry. The effect of current density, temperature and edge roughness was evaluated. All  these variables have a great influence on the size and morphology of dendrites.","palabras_clave":"DENDRITES|ELECTROGALVANIZED|ZINC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":776,"idioma_id":4,"titulo":"Reproductive and developmental costs of deltamethrin resistance in the Chagas disease vector Triatoma infestans","resumen":"                  Effective  chemical control relies on completely or strongly reducing vector population  size. However, insecticide selection pressure is often associated to the  development of resistant populations which endanger control success. In treated  areas, these resistant individuals present an adaptive advantage due to  enhanced survival. Though, resistance can also lead to negative effects when  the insecticide pressure ceases.                  In this  study, the biological effects of deltamethrin resistance were assessed in Chagas  disease vector Triatoma infestans.  Length of each developmental stage and complete life cycle, mating rate and  fecundity were evaluated. Susceptible and resistant insects presented similar  mating rate. A reproductive cost of resistance was expressed as a lower  fecundity in the resistant colony. Developmental costs were present in the  resistant colony in the form of a shortening of the second and third nymph  stage duration, and an extension of the fifth stage. A maternal effect of deltamethrin  resistance is suggested as these effects were identified in resistant females  and their progeny independently of the mated male´s deltamethrin response.                   The results  described in this work suggest the presence of pleiotropic effects of  deltamethrin resistance. Possible associations of these characters to other  traits such as developmental delays and behavioral resistance are discussed.  ","palabras_clave":"Triatoma infestans|deltamethrin resistance|fitness cost|fecundity|life cycle|developmental delay"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":780,"idioma_id":5,"titulo":"Contornos (políticos) de la sustentabilidad (económica): notas etnográficas a partir del estudio de dos organizaciones de la ?economía social?","resumen":"La sustentabilidad , como problema y categoría, resulta hoy uno de los tópicos más complejos dentro del creciente campo de la llamada ?economía social?. Desde las políticas y programas públicos o las acciones de organizaciones no gubernamentales orientadas a este sector constituye un requisito normativo que regula la circulación de recursos ?no solamente económicos sino también profesionales, políticos, etc. Desde la literatura se destaca que este constituye uno de los principales desafíos a los que deben hacer frente estas experiencias (Bryer, 2010; Rius, 2011; Rodríguez y Ciolli, 2011; Vázquez, 2010; Castelao Caruana, 2009; Hopp, 2011) . Una primera reflexión que nos invita a hacer esta constatación conduce a pensar la sustentabilidad como un imperativo que se impone ´desde arriba´ performando las prácticas de las variadas experiencias que integran este campo. Sin embargo, cuando nos acercamos desde un enfoque etnográfico podemos percibir que el problema no se agota ahí. Desde esta óptica, la sustentabilidad puede ser vista como un modo de gobierno que permea las prácticas cotidianas de estas experiencias pero también como un lenguaje que habilita o tensiona modos de actuar y sobre todo un horizonte que interpela las prácticas cotidianas de las personas que las promueven, participan e integran.","palabras_clave":"ECONOMIA SOCIAL|SUSTENTABILIDAD|PRACTICAS POLITICAS|ETNOGRAFIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":785,"idioma_id":4,"titulo":"Ghrelin increases memory consolidation through hippocampal mechanisms dependent on glutamate release and NR2B-subunits of the NMDA receptor","resumen":"Rationale  Ghrelin (Ghr) is a peptide that participates in the modulation of several biological processes. Ghr administration into the hippocampus improves learning and memory in different memory tests. However, the possible mechanisms underlying this effect on memory have not yet been clarified.  Objective  The purpose of the present work is to add new insights about the mechanisms by which Ghr modulates long-term memory consolidation in the hippocampus. We examined Ghr effects upon processes related to increased synaptic efficacy as presynaptic glutamate release and changes in the expression of the NR2B-subunits containing n-methyl-d-aspartate receptors (NMDAR), which are critical for LTP induction. We also attempted to determine the temporal window in which Ghr administration induces memory facilitation and if the described effects depend on GHS-R1a stimulation.  Results  The present research demonstrated that Ghr increased glutamate release from hippocampal synaptosomes; intra-hippocampal Ghr administration increased NR2B-subunits expression in CA1 and DG subareas and also reversed the deleterious effects of the NR2B-subunit-specific antagonist, Ro 25-6981, upon memory consolidation and LTP generation in the hippocampus. These effects are likely to be the consequence of GHS-R1a activation.  Conclusion  According to the results above mentioned and previous findings, we can hypothesize some of the mechanisms by which Ghr modulates memory consolidation. At presynaptic level, Ghr stimulates glutamate release, probably by enhancing [Ca2+]i. At postsynaptic level, the glutamate released activates NMDAR while Ghr also mediates effects directly activating its specific receptors and increases NR2B-subunit expression.","palabras_clave":"GHRELIN|MEMORY|GLUTAMATE|LTP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":794,"idioma_id":4,"titulo":"Molecular characterization of phylloxera present in Argentinean vineyards","resumen":"The presence of phylloxera in Argentinean vineyards is not considered a major threat and most of the grapevines are cultivated on their own roots. However, changes in viticultural practices during the past years, might impact the significance of the damage. The objective of this work was to characterize phylloxera in Argentina at the molecular level and to compare it with reference strains found in California. Twenty-one samples were collected from roots of V. vinifera cultivars grown in different localities of the provinces of Mendoza and San Juan. DNA was extracted using the Chelex method and amplified for 26 microsatellite markers. Results showed the presence of 2 distinct fingerprint profiles. The largest group consisted of 16 samples from South, Central and North Mendoza and San Juan. They grouped closer to the reference sample of biotype A. The smallest one consisted of 5 samples from the North-West of the province of Mendoza and grouped closer to the reference of biotype B. Although at this point DNA fingerprinting cannot inform about the aggressiveness of the phylloxera genotypes found in Mendoza and San Juan, the similarity with aggressive genotypes found in California and the presence of tuberosities in the roots from which samples were collected, suggest that the use of rootstocks should be seriously examined at vineyard planting.","palabras_clave":"PHYLLOXERA|GRAPE|MICROSATELLITE|MARKER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":800,"idioma_id":4,"titulo":"Combining water quality variables with landsat ETM+ data for remote sensing of chlorophyll-a concentration","resumen":"Río Tercero reservoir is considered the largest artificial reservoir in Córdoba province (Argentina). This multipurpose reservoir has experienced toxin-producing blooms of the cyanobacterium Microcystis on a number of occasions over the past decades. Conventional monitoring of lakes and reservoirs is time consuming and expensive. Satellite imagery is another source of information with great potential to be used for the study of water quality variables including chlorophyll-a concentration (Chl-a), among others. Different studies propose reliable relationships between remote sensing data and Chl-a, however, their procedures rely solely on spectral data and do not consider additional factors that potentially affect Chl-a. In this study, we developed a model to estimate Chl-a of Río Tercero reservoir (Córdoba, Argentina) from Landsat ETM+ data, and we improved model performance by including different water quality parameters to explain variability in Chl-a. Water quality samples were taken coinciding with the passage of ETM+ by the study area. Pearson correlation and backward multiple regression analyses were used to investigate the relationship between Chl-a, ETM+ bands and different water quality parameters. Results suggested that visible ETM+ bands (band 1-3), water surface temperature and water clarity were reliable predictors of Chl-a (R2=0.84). The procedure presented here could become a low cost measurement tool for water management authorities and decision makers, obtaining simpler and practical results for estimation of Chl-a variable, which is considered a reliable indicator of lake productivity and an ideal metric of water quality.","palabras_clave":"RESERVOIR|REMOTE SENSING|CHL-A"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":818,"idioma_id":4,"titulo":"Sexual Size Dimorphism and Age in Odontophrynus cf. barrioi (Anura: Odontophrynidae) from the Monte Desert, Argentina","resumen":"ABSTRACT.?Current knowledge on sexual dimorphism and population structure in the genus Odontophrynus is limited. We studied age structure, age at maturity, and longevity in Odontophrynus cf. barrioi, with skeletochronology. We also determined whether sexual dimorphism  in body size exists in this species, and evaluated its relation to demographic life history traits. We found that females were larger in four variables corresponding to the morphology of the head. In addition, females of O. cf. barrioi have a longer tibia-fibula and femur than males. Nevertheless, Odontophrynus cf. barrioi shows no sexual dimorphism in snout?vent length. We suggest the possibility that sexes have different growth trajectories after the onset of reproduction, as they are exposed to different selection pressures, or even predation rate, because of size differences.","palabras_clave":"EDAD|DIMORFISMO SEXUAL|ANFIBIOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":833,"idioma_id":4,"titulo":"Thermal Evolution of Na2O-K2O-CaO-SiO2-P2O5-Al2O3 Glass System and Possible Applications as Biomedical Devices","resumen":"Bioceramics are widely used materials as filling bone and implants, which can be classified into three groups according to their reactivity with the body fluid and its interaction with the bone tissue: bioinert, resorbable or bioactive. Within the last class mentioned are bioactive glasses and glass-ceramics. One of the most researched topics in this area is based on ensuring the ability of the implant to long term survival, as well as improves its mechanical properties. Hence, glass-ceramics are produced by a controlled crystallization of a glass, which enables to obtain very small crystallite sizes, that increases considerably the mechanical resistance and durability of the material. The SiO2-CaO-P2O5-Na2O system is the most widely used for the production of bioactive glasses, which can be added to other compounds such as Al2O3 that, forming part of some crystal phase in the glass- ceramic, that can provide improved mechanicalproperties. In this work, two glasses were prepared starting from commercial Bioglass composition, adding potassium and aluminum. Both were included in the formulation by means of purified feldspar. Performed tests were differential thermal analysis and X-ray diffraction in order to follow up thermal transformation and to reveal the developed phases after such treatments.","palabras_clave":"glass|bioglass"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":838,"idioma_id":4,"titulo":"Wells score and poor outcomes among adult patients with subsegmental pulmonary embolism: a cohort study","resumen":"Introduction: Since the introduction of computed tomography pulmonary angiography, isolated subsegmental pulmonary embolism has become a commonly recognized clinical problem, but its clinical relevance remains unclear. The objective of the present study was to evaluate the extent to which the simplified Wells score discriminates between patients with varying levels of risk of complications after presenting with subsegmental pulmonary embolism. Materials and Methods: Retrospective cohort study. Patients included had subsegmental pulmonary embolism (1 or multiple emboli limited to subsegmental arteries). Primary explanatory variable was the simplified Wells score, categorized as high (>4) or low (&#8805;4). The primary outcome was time to death or new venous thromboembolism. Kaplan-Meier techniques and Cox regression analysis were used to compare the survival experience of patients with high versus low Wells score with and without adjustment for active malignancy, age, Charlson score, previous venous thromboembolism, and previous major surgery in the last 30 days. Main Results: Seventy-nine patients with subsegmental pulmonary embolism were included. Patients with a high Wells score had a 4-fold increased risk of the composite outcome (hazard ratio 4.2, 95% confidence interval [CI] 2.0-8.9, P &#8804;.001). Other covariates significantly associated with increased risk in univariate analyses included active malignancy, a low serum albumin, and an increased Charlson score. In multivariate Cox regression analyses adjusting for these other factors, a high Wells score remained significant (hazard ratio 5.5, 95% CI 2.4-12.6, P &#8804; .001). Conclusion: High Wells score is associated with death or new venous thromboembolism during follow-up among patients with subsegmental pulmonary embolism. Clinical trial registration","palabras_clave":"trombosis|tromboembolismo de pulmon"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":847,"idioma_id":5,"titulo":"Notas sobre la relación entre independencia y cultura. Los casos discográfico y editorial en la ciudad de Buenos Aires en clave comparativa.","resumen":"La actual proliferación de producciones independientes en distintas áreas de la cultura constituye una particularidad de los últimos diez años en Argentina. En el marco del progresivo reconocimiento oficial de la importancia económica de las industrias culturales, las producciones editorial y musical resultan dos casos significativos de ese proceso. En ellas se ha desarrollado un conjunto de iniciativas, emprendimientos y proyectos que, poniendo el acento en lo independiente, procura crear y recrear la industria editorial y la musical. Ante la ausencia de una conceptualización precisa respecto de la relación entre independencia y cultura y a través de los casos mencionados, se indagan sus múltiples definiciones, características simbólicas y materiales así como los conflictos y tensiones allí presentes, apelando para ello a una mirada cualitativa centrada en la voz de los actores.","palabras_clave":"Producción cultural|Independiente|Música|Libros"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":850,"idioma_id":4,"titulo":"How to teach Polysystem Theory? Reflections on the evaluation process","resumen":"Le cours de premier cycle Introduction à la traductologie, dispensé à la Faculté des langues de l´Université nationale de Córdoba (Argentine), donne aux étudiants un aperçu des principaux modèles et théories de la traduction développés au XXe siècle. Le 4e module du cours aborde la Théorie des polysystèmes avancée par Itamar Even-Zohar. En partant du concept de traduction intersémiotique, les étudiants abordent des objets culturels de complexité croissante qu´ils sont censés analyser comme des produits de traduction dans un cadre polysystémique. Cet article explore les résultats des examens à l´occasion desquels les étudiants devaient décrire quatre études de cas différentes.","palabras_clave":"TRANSLATION|DIDACTICS|POLYSYSTEM|CULTURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":853,"idioma_id":4,"titulo":"A large and active debris-rockslide in the Central Andes of Argentina (30.26°S): Morphometry and triggering mechanisms","resumen":"A large (&gt;0.1 km2) and complex mass movement in the Central Andes of Argentina (final portion of Cordillera de Olivares, Frontal Cordillera), was studied to identify the triggering factors and understand their relationship with geomorphic, cryogenic and climatic dynamics. This debris-rockslide is composed of clast supported blocks of PermianeTriassic volcanic breccias. In order to characterize this feature, high resolution satellite imagery interpretation was carried out, together with the study of the landslide detachment zones and landslide bodies. These debris-rockslide events could have originated as a consequence of the combination of internal slow deformation and fragmentation under periglacial conditions, followed by a sudden collapse of the rock mass. Pre- and post-slide digital elevation models (DEMs) were created from topographical data with the help of a Geographic Information System (GIS) tool. Approximately 14.89 M m3 of rock and debris travelled nearly 2 km from an elevation of 5023 m to 4325 m asl. Although usually the origin of such catastrophic movements is related to seismically active areas with earthquakes whose magnitude frequently exceed Ms 6, our hypothesis is that this debrisrockslide event has a climatic origin caused by large snow accumulations during winters and subsequent fast meltdown processes during spring, which would have facilitated the sliding. The paper outlines the important role that snowmelt can play in the genesis and evolution of rock displacements and the importance of meteorological data, seismic catalogues, historical aerial photography and satellite images in geomorphological back-analysis.","palabras_clave":"Debris-rockslide|Morphometry|Triggering mechanisms|GIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":867,"idioma_id":4,"titulo":"Effect of dietary carotenoids on lipoperoxidation in mature sea urchins Loxechinus albus (Echinodermata: Echinoidea)","resumen":"      This  study aims to investigate the effects of dietary carotenoids on the gonad and  gut index, colour of gonads, carotenoid pigments and lipid peroxidation in the  gonads and gut of the sea urchin Loxechinus  albus. Individuals were fed for 8 weeks with the following diets: (A) fresh  algae, (B) and (C) enriched with 0.02% and 0.045% all trans &#946;-carotene,  respectively. After treatment, no significant differences were found in total  weight, test diameter, gonad and gut indexes but gonads of L. albus fed on Diet C showed a better color than those fed on  other diets. Histological analysis showed differences in the gonad reproductive  condition among treatments. The content of &#946;-carotene in gonads and gut showed  no significant differences among treatments, neither between organs. The  content of echinenone in gonads was significantly higher than in gut for Diet C  and the field control. The  lipid radical content was lower in gonads than in gut for Diet C. The content  of &#945;-tocopherol in gonads was higher in sea urchins fed on Diet C and in the  field control, than in sea urchins fed on Diet A and B. We conclude that  animals fed on Diet C showed a higher content of antioxidants, a lower lipid  peroxidation in gonads than in gut, and a delay in the onset of the spawning.  ","palabras_clave":"B-CAROTENE|A-TOCOPHEROL|ECHINONE|REPRODUCTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":868,"idioma_id":4,"titulo":"Order of convergence of the finite element method for the $p(x)-$Laplacian","resumen":"In this work, we study the rate of convergence of the finite element method for the $p(x)$-Laplacian ($1 < p1le  p(x)le   p2le  2$) in a bounded convex domain in $R^2$.","palabras_clave":"ORDEN|P(X)-LAPLACIAN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":871,"idioma_id":4,"titulo":"Processing of porous mullite ceramics using novel routes by starch consolidation casting","resumen":"In this article, the development and characterization of porous mullite bodies prepared using two novel forming routes with native starches were studied with the aim of developing bodies without deformation and with homogeneous porous microstructures. Mullite-starch suspensions specific for each route were prepared by mixing and characterized by measuring viscosity. Mullite green bodies were fabricated by heating the suspensions in metallic molds and by burning out the starch, while final porous materials were obtained by sintering at different temperatures. Bodies obtained before and after the burning-out process, and sintered disks, were characterized with porosity measurements and microstructural analysis by SEM. The phases generated after the sintering process were determined by XRD, and pore size distributions were studied by Hg-porosimetry. The obtained results showed that the use of both routes allowed the shaping of homogeneous mullite bodies without causing cracks or deformations and the consequent development of controlled porous mullite microstructures.","palabras_clave":"STARCH CONSOLIDATION CASTING METHOD|MULLITE|MICROSTRUCTURE|POROUS CERAMICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":876,"idioma_id":4,"titulo":"Investment planning in energy considering economic and environmental objectives","resumen":"This work proposes a linear disjunctive multiperiod optimization model for planning investments in energy sources considering two objectives, one economical (maximization of the net present value), and the other environmental  (minimization of greenhouse gas emissions - GHG). The general goal of this approach is to provide an analysis tool for energy decision makers, for planning investment energy sources considering different scenarios in the GHG emanation. The decisions variables of the model are the investments needed in money, capacity and time in order to satisfy 100% of the energy market for Argentina from period 2010-2030. Two models are proposed, the first one considers the total amount of GHG released in the horizon time; and the other evaluates the amount of GHG released year by year. Twenty scenarios are evaluated with both models. The results obtained are presented, which show the trade-offs between both objectives.","palabras_clave":"Renewable energy|Investment planning|Multi-objective multiperiod optimization|Environmental and Economic impacta"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":880,"idioma_id":5,"titulo":"Evidencias de actividades metalúrgicas en el sitio Campo de Carrizal  (Belén, Catamarca)","resumen":"En el presente trabajo se dan a conocer las evidencias de actividades metalúrgicas desarrolladas en el pasado en la zona de Azampay (Belén, Catamarca). Los hallazgos fueron realizados en el sitio Campo de Carrizal, adscripto al Período Tardío de la Región valliserrana del Noroeste argentino. El sitio está conformado por un conjunto de núcleos habitacionales que constan de uno o más recintos sub-rectangulares edificados sobre niveles aterrazados artificialmente, sobre tres espolones de un cerro localizado al sur de la Quebrada de Carrizal.  Rodean a los núcleos habitacionales extensos campos de cultivo. En dos de los recintos excavados  - Esp.2 NH2 Rec. 1 y Esp.3 NH2 Rec.1  -, fueron hallados restos que evidencian actividades metalúrgicas: fragmentos de metal, restos de fundición, trozos de mineral y fragmentos cerámicos refractarios. En este trabajo presentamos los resultados de los estudios efectuados sobre esas evidencias de producción metalúrgica, en función de los cuales se sugiere que los pobladores de Campo de Carrizal obtuvieron cobre por fundición de sus menas, alearon cobre con estaño para conformar bronce, probablemente en algunos de los crisoles recuperados, y fabricaron objetos por vaciado en moldes y, quizás también, por laminado.","palabras_clave":"METALURGIA|PERÍODO TARDÍO|ÁREA VALLISERRANA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":911,"idioma_id":5,"titulo":"TRANSFORMACIONES EN LAS FORMAS DE DIFUNDIR RESULTADOS DE INVESTIGACION. IMPLICANCIAS SOCIALES Y ÉTICAS DE LA PUBLICACIÓN DE ETNOGRAFIAS EN REPOSITORIOS DE ACCESO ABIERTO EN INTERNET","resumen":"En este artículo abordamos las transformaciones en las condiciones de divulgación de las investigaciones desarrolladas en organismos del Sistema Nacional de Ciencia, Tecnología e Innovación (SNTCI) en Argentina a partir de la implementación del modelo de acceso abierto. Estas transformaciones introducidas con la finalidad de democratizar el acceso al conocimiento requieren avanzar en discusiones y acuerdos más específicos a fin de tener en cuenta sus implicancias sociales y éticas concretas. En ese sentido, proponemos una reflexión sobre las particularidades que esa discusión asume para la investigación antropológica, en especial etnográfica, dando nuevos sentidos a debates metodológicos y éticos tradicionales de la disciplina.","palabras_clave":"ETNOGRAFIA|INTERNET|ACCESO ABIERTO|CONOCIMIENTO PÚBLICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":921,"idioma_id":5,"titulo":"VINCULACIÓN DE LAS REFERENCIAS ALTIMÉTRICAS DE LAS CARTAS NÁUTICAS CON EL ELIPSOIDE WGS84 PARA EL RÍO DE LA PLATA","resumen":"Las profundidades que brindan las cartas náuticas se calculan como la distancia entre la topografía submarina y el Nivel de Reducción de Sondajes (NRS). Estas profundidades se obtienen a partir de sondajes que deben ser corregidos por varios factores entre los que se destaca por su magnitud la corrección por marea, quetradicionalmente se estima a partir de observaciones de marea en ubicaciones cercanas o dentro de la zona del relevamiento batimétrico. Esta estimación incide directamente en el resultado de la profundidad y puede introducir un error significativo en el cálculo de la misma. La obtención de la corrección por marea a través de la altura elipsoidal que proveen los sistemas globales de navegación satelital (GNSS) permite conocer la distancia que hay entre la superficie del agua y el NRS en la posición del buque, simplificando el cálculo y mejorando la precisión de la corrección por marea que se aplica a los sondajes. Sin embargo, para poder aplicar esta metodología es necesario haber establecido previamente la relación que hay entre los NRS y el origen de la coordenada vertical de los GNSS. El objetivo de este trabajo es generar para el Río de la Plata un modelo que relacione los NRS utilizados en las cartas náuticas del Servicio de Hidrografía Naval Argentino, con el sistema de referencia que utiliza el Sistema de Posicionamiento Global (GPS), el elipsoide WGS84, materializado en Argentina por el marco de referencia POSGAR07. Esta relación se establece a través de la superficie del Nivel Medio del Mar (NMM), modelada en los dos sistemas de referencia. Para seleccionar la representación del NMM, referida al elipsoide WGS84, que mejor se ajusta al Río de la Plata, se comparan los modelos globales de NMM, DTU10MSS y CLS2011, y los modelos de geoide EGM2008 y GAR, con mediciones altimétricas satelitales de las misiones Topex\/Poseidon, Jason1 y Jason2, a las que se les aplican nuevas correcciones de marea y de efecto atmosférico que permiten obtener, a partir de cada observación, el valor del NMM. El promedio y el desvío estándar de las diferencias de los modelos y las observaciones satelitales corregidas son respectivamente: EGM2008 (0,40 m; 0,16 m), GAR (0,25 m; 0,22 m), DTU10 MSS (-0,01 m; 0,17 m), CLS2011 (0,00 m; 0,16 m). Los NRS del Río de la Plata y su relación con el NMM se obtienen a partir de la información que proveen las cartas náuticas. Se calcula la relación entre los NRS y el elipsoide WGS84 a través de la diferencia entre el NMM referido a los NRS y el modelo de NMM CLS2011 referido al elipsoide WGS84, por ser el que muestra un mejor ajuste en el Río de la Plata. El error esperado del modelo obtenido (0,30 m) es comparable al error máximoadmisible para las profundidades que se utilizan en las cartas náuticas en el Río de la Plata. El modelo generado permite obtener una novedosa vinculación para la zona, y constituye el primer paso para desarrollar una metodología que permita obtener la profundidad de las cartas náuticas a partir de sondajes y observaciones GPS.","palabras_clave":"Referencias altimétricas|Nivel de Reducción de Sondajes|Río de la Plata|Nivel Medio del Mar"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":926,"idioma_id":4,"titulo":"Development and Implementation of a Supervisor Strategy and Sliding Mode Control Setup for Fuel Cell-Based Hybrid Generation Systems","resumen":"This paper presents the development and experimental  results of a supervisor strategy and a sliding mode  control setup to improve the performance of hybrid generation  systems. The topology in this work is conformed by a core,  comprising a Fuel CellModule and a SupercapacitorModule, in  combination with an Alternative Energy Source Module and an  electrolyzer. In particular, a wind power turbine is considered as  alternative power source, to attain a hybrid generation system  fully relying on renewable energy. Firstly, a supervisor strategy  is proposed to manage the power flows of the subsystems and  coordinate the system as a whole. Subsequently, a sliding mode  control setup for combined operation of the DC\/DC power  converters of the Fuel Cell\/Supercapacitor core is presented to  track the power references synthesized by the supervisor control.  Both control levels, supervisor strategy and sliding mode  controllers, are implemented and assessed through extensive  experimental tests, under different wind conditions and heavy  load changes.","palabras_clave":"Hybrid Systems|Sliding Mode Control|Fuel Cells|Supercapacitors"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":930,"idioma_id":4,"titulo":"Optimal exponents in weighted estimates without examples","resumen":"We present a general approach for proving the optimality of the exponents on weighted estimates.     We show that the optimal exponent on the Ap characteristic in a eighted bound for a given operator T is closely related to the asymptotic  behaviour of the unweighted Lp norm of T as p goes to 1 and infinity.  By combining these results with the known weighted inequalities, we  derive the sharpness of the exponents, without building any specic example, for a wide class of operators including maximal-type, Calderon{  Zygmund and fractional operators. In particular, we obtain a lower  bound for the best possible exponent for Bochner-Riesz multipliers. We  also present a new result concerning a continuum family of maximal operators on the scale of logarithmic Orlicz functions. Further, our method allows to consider in a unied way maximal operators dened over very general Muckenhoupt bases.","palabras_clave":"MUCKENHOUPT WEIGHTS|CALDERON-ZYGMUND OPERATORS|MAXIMAL FUNCTIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":937,"idioma_id":5,"titulo":"La desorganización de la acción de clase en la Argentina reciente y los problemas conceptuales para el estudio del conflicto obrero","resumen":"Este artículo se propone discutir algunas tendencias del conflicto obrero y su lugar en el conflicto social en Argentina desde 1989 como una aproximación a los procesos de formación y desorganización de la acción colectiva de clase de los asalariados. Simultáneamente, trata el problema de las categorías de análisis del conflicto social y, particularmente, el laboral para la medición de la conflictividad. Para esto se implementó una estrategia de análisis cuantitativo del conflicto a partir de datos de producción propia y de otros investigadores. La principal hipótesis es que durante la década de 1990 se desarrolló en Argentina un proceso de desorganización de la acción de clase de los asalariados, caracterizado por la pérdida de peso social de las acciones de clase dentro del conjunto de las luchas sociales y la fragmentación de las acciones de la clase obrera. Dicho proceso puso en crisis las formas tradicionales de conceptualizar y medir el conflicto social, particularmente el obrero, y exige la adecuación de los instrumentos teóricos y metodológicos con el fin de aprehender las tendencias disímiles del conflicto obrero y social.","palabras_clave":"Conflicto Social|Clases Sociales|Identidades|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":960,"idioma_id":5,"titulo":"Semillas, ciencia y propiedad. Una mirada al ciclo de producción de conocimiento científico y tecnológico en el INTA de Argentina","resumen":"Este artículo reflexiona sobre la producción pública de ciencia y tecnología orientada a la actividad agropecuaria en Argentina. A partir de la reconstrucción de la trayectoria histórica del Instituto Nacional de Tecnología Agropecuaria (INTA) en la generación, adaptación y difusión de semillas mejoradas, se explora su dinámica de investigación. El estudio se centra en las décadas de 1970 y 1980, coincidente el período correspondiente a su intervención durante la última dictadura, a través de una mirada panorámica de larga duración. Con el objetivo de identificar continuidades y rupturas en su trayectoria, se exploran vinculaciones con transformaciones sectoriales, políticas y económicas. Se analizan, en particular en la producción de híbridos de maíz, mecanismos de cooptación, apropiación y transferencia de conocimientos del ámbito público al privado.  El corpus documental analizado está conformado por materiales de investigación, actas y resoluciones institucionales,  y entrevistas a técnicos e investigadores del INTA.","palabras_clave":"SEMILLAS|CIENCIA|PROPIEDAD|INTA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":964,"idioma_id":4,"titulo":"Progesterone causes metabolic changes involving aminotransferases and creatine kinase in cryopreserved bovine spermatozoa","resumen":"Progesterone causes metabolic changes involvingaminotransferases and creatine kinase in cryopreserved bovine spermatozoaSilvina Fernández, Mariana Córdoba&#8727;Cátedra de Química Biológica, Instituto de Investigación y Tecnología en Reproducción Animal, Facultad de Ciencias Veterinarias,Universidad de Buenos Aires, Av. Chorroarín 280 1427 Ciudad Autónoma de Buenos Aires, Argentina.Progesterone (P4) is capable of inducing acrosome reaction in many species. The objective of this study was to determine the activity of enzymes involved in metabolism that contribute to the redox state and supply energy for acrosome reaction in cryopreserved bull spermatozoa. To accomplish this aim, acrosome reaction was induced by P4 in capacitated and non-capacitated samples. Alanine and aspartate aminotransferases (ALT, AST) and creatine kinase (CK) activities were measured spectrophotometrically at 340nm after acrosome reaction with P4. Oxygen consumption was measured polarographically. ALT and AST activities increased by the addition of P4 capacitated and non-capacitated samples. P4 addition provoked an increase in CK activity in non-capacitated spermatozoa compared to heparin capacitated spermatozoa with or without P4 addition. P4 increased oxygen consumption, the percentage of acrosome reacted spermatozoa as well as the absence of acrosome integrity in both capacitated and non-capacitated bovine spermatozoa, but oxygen consumption in P4 samples was significantly lower than in heparin capacitated spermatozoa (P<0.05). Acrosome reaction induction by P4 required different creatine kinase activity with the same oxygen consumption and transaminases level to maintain oxidative metabolism and redox state through reducing equivalents transfer between cytosolic and mitochondrial compartment. In conclusion, P4 induces a lower oxidative metabolism during acrosome reaction in bovine cryopreserved spermatozoa, compared to heparin induced capacitation process.","palabras_clave":"aminotransferases|creatine kinase|bovine sperm"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":969,"idioma_id":5,"titulo":"El concepto de posición docente: notas conceptuales y metodológicas","resumen":"Las regulaciones del trabajo docente han sido posiblemente uno de los temas más abordados en los estudios de historia, política y sociología de la educación en los últimos años. Desde diversos marcos teóricos y epistemológicos, un vasto número de investigaciones se han dedicado a analizar la cuestión para aproximarse a dar cuenta de problemas tales como las relaciones entre educación escolar y reproducción social y cultural, los vínculos entre el trabajo docente y la producción o el combate de la desigualdad, las disputas en torno de derechos laborales de los profesores, las diversas orientaciones que el Estado y otros actores pretenden imprimir al trabajo de enseñar, los diversos modos en que los docentes recepcionan y resignifican las políticas públicas en educación, sus concepciones respecto de dicho trabajo y de los estudiantes, las formas de razonamiento en torno del género, la raza, la clase social y la diferencia que operan como fundamento de las prácticas de los enseñantes, entre otros temas de destacada relevancia en la agenda de investigación educativa de nuestro país y en la región.  En este artículo nos proponemos desarrollar el modo en que sería posible abordarla desde una categoría que hemos elaborado como producto de la investigación: ?posición docente?. También, presentaremos una serie de movimientos y recorridos teóricos que sustentan esta opción. Para ello, nos detendremos en una serie de aportes que las perspectivas posfundacionales, y en particular el Análisis Político del Discurso, han realizado, con consecuencias teóricas y metodológicas para el estudio de las regulaciones del trabajo docente. En particular, consideraremos la configuración discursiva, abierta y contingente, de las relaciones e identidades sociales y las identificaciones como procesos de sutura y fijación temporarios, procurando dar cuenta del modo en que la noción de posiciones de sujeto habilita otros modos de pensar dichas configuraciones y permite plantear la categoría de ?posición docente?.","palabras_clave":"Regulación docente|posiciones dinamicas|Identidades indeterminadas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":970,"idioma_id":4,"titulo":"Influence function of projection-pursuit principal components for functional data","resumen":"In the finite-dimensional setting, Li and Chen (1985) proposed a method for principal components analysis using projection-pursuit techniques. This procedure was generalized to the functional setting by Bali et al. (2011), where also different penalized estimators were defined to provide smooth functional robust principal component estimators. This paper completes their study by deriving the influence function of the functional related to the principal direction estimators and their size. As is well known, the influence function is a measure of robustness which can also be used for diagnostic purposes. In this sense, the obtained results can be helpful for detecting influential observations for the principal directions.","palabras_clave":"Elliptical distribution|Fisher-consistency|Functional principal component|Influence function|Robust estimation|Smoothing"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":971,"idioma_id":4,"titulo":"A comparison of heterochromatic regions in three species of neotropical canids","resumen":"Repetitive DNA varies in nature and abundance, and has had an important role in genome evolution of higher eukaryotes. In the present study we analyzed the dynamics of heterochromatic regions and telomeric sequences in three endemic South American canid species, Chrysocyon brachyurus, Lycalopex gymnocercus, and two subspecies of Cerdocyon thous by means of C-banding and fluorescence in situ hybridization (FISH) with telomeric probes. The three species revealed different banding patterns evidencing amplifications of centromeric heterochromatic and telomeric regions co-localized with telomeric sequences in L. gymnocercus and C. thous, and the presence of a heterochromatic terminal block in the Y chromosome of C. brachyurus. Additionally, an unusual heteromorphism of chromosome pair 1 was observed in the subspecies Cerdocyon thous entrerrianus. Our work emphasizes the importance of cytogenetic studies at the population level comprising the largest possible area of the geographic distribution of the species.","palabras_clave":"Canidae|Chromosomal polymorphism|Repetitive sequences|Sex chromosomes|Telomeric sequencesa"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":975,"idioma_id":4,"titulo":"Pregnant women's secondhand smoke exposure and receipt of screening and brief advice by prenatal care providers in Argentina and Uruguay.","resumen":"AbstractSecondhand smoke (SHS) exposure has negative effects on maternal and infant health. SHS exposure among pregnant women in Argentina and Uruguay has not been previously described, nor has the proportion of those who have received screening and advice to avoid SHS during prenatal care. Women who attended one of 21 clusters of publicly-funded prenatal care clinics were interviewed regarding SHS exposure during pregnancy at their delivery hospitalization during 2011-2012. Analyses were conducted using SURVEYFREQ procedure in SAS version 9.3 to account for prenatal clinic clusters. Of 3,427 pregnant women, 43.4 % had a partner who smoked, 52.3 % lived with household members who smoked cigarettes, and 34.4 % had no or partial smoke-free home rule. Of 528 pregnant women who worked outside of the home, 21.6 % reported past month SHS exposure at work and 38.1 % reported no or partial smoke-free work policy. Overall, 35.9 % of women were exposed to SHS at home or work. In at least one prenatal care visit, 67.2 % of women were screened for SHS exposure, and 56.6 % received advice to avoid SHS. Also, 52.6 % of women always avoided SHS for their unborn baby´s health. In summary, a third of pregnant women attending publicly-funded prenatal clinics were exposed to SHS, and only half of pregnant women always avoided SHS for their unborn baby´s health. Provider screening and advice rates can be improved in these prenatal care settings, as all pregnant women should be screened and advised of the harms of SHS and how to avoid it.","palabras_clave":"Pregnant Women's"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":978,"idioma_id":5,"titulo":"Entre el sumak kawsay y la 'vida en armonía con la naturaleza': disputas en la circulación y traducción de perspectivas respecto de la regulación de la cuestión ecológica en el espacio global","resumen":"Este artículo se propone examinar el proceso de circulación del buen vivir desde Ecuador y Bolivia hacia el campo de regulación global del ambiente con el objeto de desestabilizar las diferentes operaciones que opacan u ocultan la diversidad de miradas en relación a la cuestión ecológica. Mediante el examen de un corpus documental integrado por regulaciones provenientes del espacio nacional (Ecuador, Bolivia) y de la escala global (convenciones, declaraciones, resoluciones e informes de Naciones Unidas) analizamos cómo la perspectiva del sumak kawsay viaja y se traduce desde el Sur hacia el Norte, dialogando con la idea de armonía con la naturaleza, concepto que se ha transformado en un campo de disputa por dar respuesta al problema ecológico revisando el vínculo entre naturaleza y sociedad.","palabras_clave":"BUEN VIVIR|ARMONÍA CON LA NATURALEZA|CUESTIÓN ECOLOGICA|REGULACIÓN GLOBAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":985,"idioma_id":4,"titulo":"META-TYROSINE. A POWERFUL ANTI-METASTATIC FACTOR WITH UNDETECTABLE TOXIC-SIDE EFFECTS","resumen":"Abstract: Meta-tyrosine: a powerful anti-metastatic factor with undetectable toxic-side effects. Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. While former studies have indicated that T-cell dependent processes mediate CR in hosts bearing immunogenic small tumors, the most universal manifestation of CR induced by immunogenic and non-immunogenic large tumors had been associated with an antitumor serum factor that remained an enigma for many years In a recent paper, we identified that elusive factor(s) as an equi-molar mixture of meta-tyrosine and ortho-tyrosine, two isomers of tyrosine that are not present in normal proteins and that proved to be responsible for 90% and 10%, respectively, of the total serum anti-tumor activity. In this work, we have extended our previous findings demonstrating that a periodic intravenous administration of meta-tyrosine induced a dramatic reduction of lung and hepatic metastases generated in mice bearing two different metastatic murine tumors and decreased the rate of death from 100% up to 25% in tumor-excised mice that already exhibited established metastases at the time of surgery. These anti-metastatic effects were achieved even at very low concentrations and without displaying any detectable toxic-side effects, suggesting that the use of meta-tyrosine may help to develop new and less harmful means of managing malignant diseases, especially those aimed to control the growth of metastases that is the most serious problem in cancer pathology","palabras_clave":"META TIROSINA|ORTO TIROSINA|ISOMEROS|METASTASIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":994,"idioma_id":4,"titulo":"Primary and secondary lithic raw material sources along the western coast of San Matías Gulf (Río Negro province, Argentina): A first approach to their spatial variability","resumen":"In this article we present a first description of lithic raw material sources, and their particular geological and geomorphological characteristics, from the south part of the western coast of San Matías Gulf. The study area lineally covers ~125 km of the west coast of Río Negro province, Patagonia, Argentina (from 404803.2200S, 654015.7700W to 4155043.6000S, 653050.1500W). The sources uncovered include concentrations of different types of shingle to primary outcrop, which is an exceptional find considering that to date all known sources along the western and the northern coasts of the Gulf were secondary.As a result we now know about a considerable number of rock types of varying quality for knapping, as well as their differential distribution across space. This allows us, for the first time in our study area, to study procurement and exploitation strategies for these raw materials and also to briefly discuss the existing contrasts in rock availability across different sectors of space. The results of these studies suggest that the differential representation of these rocks in the archaeological record across space was related to variations in their spatial and temporal availability, which in turn was tied to the very formation process of the coastal archaeological record of this north Patagonian area.","palabras_clave":"SAN MATIAS GULF|WESTERN COAST|LITHIC RAW MATERIAL|PRIMARY AND SECONDARY SOURCES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":996,"idioma_id":5,"titulo":"MIGRACIÓN LABORAL TEMPORARIA Y ECONOMÍA DOMÉSTICA EN LAS ESTRATEGIAS DE REPRODUCCIÓN SOCIAL: EL CASO DE LOS TRABAJADORES FORESTALES DE BERNARDO DE IRIGOYEN (MISIONES, ARGENTINA).","resumen":"El objetivo de este artículo es analizar cómo las unidades domésticas participes de la migración laboral temporaria articulan distintos mecanismos de reproducción social, haciendo énfasis en el lugar que ocupan las prácticas agropecuarias a pequeña escala. Nuestro referente empírico es un conjunto de Unidades domésticas ubicadas en la zona rural del municipio de Bernardo de Irigoyen (Misiones, Argentina) que cuentan con algún\/os miembros que migran o han migrado hacía otras provincias para emplearse en el sector forestal. La metodología empleada es de tipo cualitativa mediante la utilización de entrevistas a miembros migrantes y no migrantes de las unidades domésticas analizadas, complementadas con observaciones. Este artículo concluye que en aquellos grupos domésticos con mayores dificultades de inserción al mercado laboral, las prácticas agropecuarias, junto con las transferencias monetarias estatales, son centrales en la reproducción social. Por el contrario, en aquellos casos en que algún miembro de la unidad doméstica sostiene una inserción al mercado laboral relativamente estable, las prácticas prediales tienen una importancia secundaria o nula para la subsistencia del grupo. Asimismo, las distintas formas de configuración de estrategias de reproducción  varían según las características de la unidad doméstica y se vinculan con distintas formas de división familiar del trabajo,  prácticas de consumo y  estrategias de escolarización.","palabras_clave":"Estrategias de reproducción social|unidades domésticas |migración laboral |economía doméstica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":1135,"idioma_id":5,"titulo":"Effect of surface modification on the corrosion resistance of Zr 2.5Nb as material for permanent implants","resumen":"          Zirconium is a potential material for permanent implants. In particular, surface modification induced by anodisation has proved to be effective to improve corrosion resistance while keeping good osseointegration. The combination of zirconium with niobium is supposed to develop a structure that presents a high corrosion resistance and continues having the mechanical resistance necessary for implants. The aim of the present work is to determine the viability of using anodised Zr2.5Nb as implant material, and compare it with pure Zr. Electrochemical tests performed in the anodizing solution and in a simulated biological solution revealed that by anodising the materials a higher corrosion resistance is obtained. The improvement on the corrosion resistance is particularly noticeable in the case of the pure metal after a short period immersed in the simulated biological solution. But, after a long period of immersion, the alloy shows better performance. ","palabras_clave":"Zirconium|IMPLANTS|SURFACE MODIFICATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":1146,"idioma_id":4,"titulo":"Additive synthesis by sol-gel method for its use as antimicrobial","resumen":"The antimicrobial activity of silver nanoparticles makes this chemical element attractive for their incorporation in different  materials. Additionally, heteropolyacids (HPAs) have advantages as catalysts which make them environmentally very interesting.  The objective of this work is to incorporate in a silica matrix obtained by sol-gel an HPA together with Ag, for their use as fillers  in paints or adhesives. Six samples were synthesized, using tetraethyl orthosilicate, methyltrimethoxysilane, acetic acid,  molydophosphoric acid and silver acetate. The silicas were characterized by potentiometric titration, XRD, SEM, TEM, SBET and  FT-IR. When HPA is used instead of acetic acid, a variation on the final acidity is produced. The specific surface area decreases  when HPA is incorporated into the silica synthesized using tetraethyl orthosilicate as precursor, noticing a slight increase when  Ag is added because a different distribution of HPA in the matrix. By SEM, it was observed that the particle size is bigger when  the silicas are synthesized with TEOS-HPA, but it still shows the characteristic morphology of bulk silica.","palabras_clave":"sol-gel|additives"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":1256,"idioma_id":4,"titulo":"Implementation of different technics for the monitoring of reinforced concretes corrosion applied to rebar embedded in concretes with ordinary and pozzolanic Portland cement","resumen":"For the development of an intermediate radioactive waste repository, two different types of reinforced concrete were analyzed interms of durability: one made with ordinary portland cement and the other one made with pozzolanic cement. The values forcompressive strength, sorptivity and air permeability demonstrate that the formulations are compatible with the requiredapplication. The corrosion rate of rebar up to about 300 days of monitoring and obtained with sensors is below the thresholdvalue required for this type of facilities, except when temperatures are high. The value for the same parameter monitored by thegalvanostatic pulse technique using superficial counter electrode and guard electrode is always lower than the threshold value.Additionally, when applying the galvanostatic pulse technique using embedded electrodes, this parameter is comparable to theguard electrode method only when the polarization resistance is calculated through non-linear fitting.","palabras_clave":"RADIOACTIVE WASTE|CORROSION|REINFORCED CONCRETE DURABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":1278,"idioma_id":4,"titulo":"Deprivation and the Dimensionality of Welfare: A Variable-Selection Cluster-Analysis Approach","resumen":"We approach the problems of measuring the dimensionality of welfare and that of identifying the multidimensionally poor, by first finding the poor using the original space of attributes, and then reducing the welfare space. The starting point is the notion that the `poor´ constitutes a group of individuals that are essentially different from the `non-poor´ in a truly multidimensional framework. Once this group has been identified through a clustering procedure, we propose reducing the dimension of the original welfare space using recent blinding methods for variable selection. We implement our approach to the case of Latin America based on the Gallup World Poll, which contains ample information on many dimensions of welfare.","palabras_clave":"Multidimentional Welfare|Poverty|Factor Analysis|Cluster"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":1318,"idioma_id":4,"titulo":"Variable order smoothness priors for ill-posed inverse problems","resumen":"In this article we discuss ill-posed inverse problems, with an emphasis on hierarchical variable order regularization. Traditionally, smoothness penalties in Tikhonov regularization assume a fixed degree of regularity of the unknown over the whole domain. Using a Bayesian framework with hierarchical priors, we derive a prior model, formally represented as a convex combination of autoregressive (AR) models, in which the parameter controlling the mixture of the AR models can dynamically change over the domain of the signal. Moreover, the mixture parameter itself is an unknown and is to be estimated using the data. Also, the variance of the innovation processes in the AR model is a free parameter, which leads to conditionally Gaussian priors that have been previously shown to be much more flexible than the traditional Gaussian priors, capable, e.g., to deal with sparsity type prior information. The suggested method, the Weighted Variable Order Autoregressive model (WVO-AR) is tested with a computed example.","palabras_clave":"Markov autoregresive models|Inverse problems|ill-conditioned |Bayesian models"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":1469,"idioma_id":4,"titulo":"Resource exploitation and Human Mobility: Trends in the archaeofaunal and isotopic record from Central Western Argentina","resumen":"Zooarchaeological information was used to understand changes in the human diet trough time in southern Mendoza province, Argentina.  Those changes where explained by a decrease in the residential mobility pattern forced by the intensification in the use of resources and lately by the introduction of the first domesticated ca 2000 years BP. I this paper we revised the archaeofaunal tendencies crossing the zooarchaeological information whit the spatial distribution of the animal resources in the region.  The result shows that the zooarchaeological assemblages have a stronger correlation with the altitude (environmental diversity) than with the temporal appearance of the domesticated.  However, the archaeofaunal information as well as the human isotope data suggest that the residential mobility reduction postulated in the previous paper took place, modifying the the expected diversity distribution through the landscape.","palabras_clave":"Zooarchaeology|South America|Hunter Gatherers|Subsistence|Late Holocene"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":1837,"idioma_id":4,"titulo":"Relationship between biophysical parameters and synthetic indices derived from hyperspectral field data in a coastal marsh from Buenos Aires Province, Argentina","resumen":"Remote sensing tools allow the environmentalevaluation of coastal wetlands at a landscape scale, but adeeper understanding is needed of the interactions betweenbiophysical parameters and the electromagnetic signal. Thegoal of this work was to analyze and quantify the influenceof the aboveground biomass and the Leaf Area Index (LAI) onthe spectral response of Spartina densiflora marshes in MarChiquita coastal lagoon, Argentina. Spectral reflectance athigh resolution was measured in S. densiflora canopies undernatural conditions, manipulating standing crop by means ofsuccessive harvest. Reflectance data were acquired using aspectroradiometer in visible, near infrared (IR) and shortwaveIR bands. Spectral Vegetation Indices (VI) were calculated foreach standing crop-LAI situation. Several VI significantly correlatedwith standing crop and LAI, including indices 1) basedon the red-IR edge (IR Index (IRI), 695\/760 ratio, Simple Ratio(SR), Red Edge Inflection Point (REIP), and different variationsof the Normalized Difference VI (NDVI Rouse, NDVI amber,NDVI NOAA, NDVI Landsat, NDVI Modis), 2) indices basedon the sharp change green-IR (green NDVI (GNDVI), 800\/550ratio) and 3) indices with a correction for soil noise (OSAVI:Optimized Soil Adjusted VI (OSAVI), and Modified SAVI(MSAVI). The indices with significant regressions with standingcrop and LAI were IRI, NDVIAmber and REIP. The total andgreen standing crop showed better adjustments than LAI, showingR2 values of 0.5. These values were obtained withREIP index. Results indicate that LAI and standing cropof S. densiflora stands could be determined from spectral databut estimations should be taken carefully in high biomassscenarios, because of indexes saturation at higher LAI values.","palabras_clave":"HYPERSPECTRAL DATA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2225,"idioma_id":5,"titulo":"'Marcelo Cohen. Las fundaciones de la ciencia ficción (Parte II: La comunidad).'","resumen":"El presente trabajo constituye una continuación de 'Marcelo Cohen. Las fundaciones de la ciencia ficción', texto también publicado en la revista Orbis Tertius (n° 19 del año 2013). Allí ya se anticipaba que el problema de la formulación ontológica subjetiva en Cohen suponía un interrogante en torno a la comunidad. En esa instancia, se dejaron asimismo esbozados algunos aspectos del problema del estar-en-común para ser desarrollados en futuros trabajos. En sintonía con dicha propuesta, se retoman aquí los problemas de la ontología coheniana para luego postular que el problema de la comunidad ya se encuentra en germen en el mismo paradigma que el autor recupera y reformula. En Cohen, la propuesta romántica de una unión entre arte-ciencia-filosofía-religión-política se reactualiza. En este trabajo se analizan sus inflexiones.","palabras_clave":"MARCELO COHEN|CIENCIA FICCIÓN|ROMANTICISMO|CUÁNTICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2443,"idioma_id":5,"titulo":"Evaluación de relaciones acuífero libre - lagunas mediante modelación hidrogeoquímica e isotópica en la planicie medanosa del sur de Córdoba - Argentina","resumen":"Se evaluaron las relaciones hidrúlicas y geoquímicas entre el acuífero libre y lagunas. Se efectuó la modelación numérica hidrogeoquímica e isotópica en la planicie medanosa del sur de Córdoba ? Argentina","palabras_clave":"RELACIONES HIDRÁULICAS|ACUÍFERO|LAGUNA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2449,"idioma_id":4,"titulo":"The rheological properties of lipid monolayers modulate the incorporation of L-ascorbic acid alkyl esters","resumen":"The L-ascorbic acid alkyl esters (ASCn) arelipophilic forms of vitamin C that have been used in topical pharmacologicalpreparations. For this study two ASCn members were selected: ASC16and ASC14, which have different rheological properties whenorganized at the air\/water interface by themselves. Also, the effect of thephase state of the host lipid membranes on ASCn incorporation wasexplored, using Langmuir monolayers as model system. For this purpose, films ofpure lipids with known phase states have been selected, such asliquid-expanded, liquid-condensed and solid phases as well as pure cholesterolfilms which behave as in liquid-ordered state. We also tested ternary andquaternary mixed films that mimic the properties of cholesterol containing membranesand of the stratum corneum. The compressibility and shear properties of thosemonolayers were assessed in order to define its phase properties. We found thatthe length of the acyl chain of the ASCn compounds inducesdifferential changes in the rheological properties of the host lipid membrane,and subtly regulates the kinetics and extent of the penetration process. Thecapacity for ASCn uptake was found to depend on the phase state ofthe host film. The increase in surface pressure resultant after amphiphileincorporation appears to be a function of the capacity of the host membrane toincorporate such amphiphile as well as the rheological response of the film. Hence,monolayers that show a solid phase state responded with a larger surfacepressure increase to the incorporation of a comparable amount of amphiphilethan liquid-expanded ones. The cholesterol- containing films, including themixture that mimics stratum corneum, allowed a very scarce ASCnuptake independently of the membrane diffusional properties. This suggests animportant contribution of Cho on the maintenance of the barrier function ofstratum corneum.","palabras_clave":"ASCORBYL PALMITATE|LIQUID ORDERED PHASE|LANGMUIR MONOLAYERS|DRUG-MEMBRANE INTERACTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2453,"idioma_id":4,"titulo":"In vivo effects of Maillard reaction products derived from biscuits","resumen":"The antioxidant activity, antihypertensive effect and prebiotic activity of Maillard reaction products(MRPs) derived from biscuits were investigated in Wistar rats. Animals were fed the following dietsfor 6 weeks: control (AIN-93 diet); Asc-diet (AIN-93 diet with ascorbic acid in the drinking water); HTBdiet (containing high amount of MRP derived from biscuits) and LT-B diet (containing negligibleamounts of biscuit MRP). Serum antioxidant activity (FRAP, ABTS), as well as lipid peroxidation(TBARS) were determined at the end of the experiment. Results showed that dietary MRP reduced thefood efficiency, increased the antioxidant activity of serum, increased the ratio between lactic and totalaerobic bacteria, increased water-holding capacity of faeces and reduced blood pressure, but did notreduce mineral absorption. Therefore, the biscuit MRP functional claims could be demonstrated by anin vivo study.","palabras_clave":"MAILLARD REACTION PRODUCTS|BISCUITS|IN VIVO|ANTIHYPERTENSIVE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2454,"idioma_id":4,"titulo":"The role of discharge variability in determining alluvial 1 stratigraphy","resumen":"We illustrate the potential for using physics-based modeling tolink alluvial stratigraphy to large river morphology and dynamics.Model simulations, validated using ground penetrating radar datafrom the Río Paraná, Argentina, demonstrate a strong relationshipbetween bar-scale set thickness and channel depth, which appliesacross a wide range of river patterns and bar types. We show thathydrologic regime, indexed by discharge variability and flood duration,exerts a first-order influence on morphodynamics and hence barset thickness, and that planform morphology alone may be a misleadingvariable for interpreting deposits. Indeed, our results illustratethat rivers evolving under contrasting hydrologic regimes may havevery similar morphology, yet be characterized by marked differencesin stratigraphy. This realization represents an important limitationon the application of established theory that links river topographyto alluvial deposits, and highlights the need to obtain field evidenceof discharge variability when developing paleoenvironmental reconstructions.Model simulations demonstrate the potential for derivingsuch evidence using metrics of paleocurrent variance.","palabras_clave":"ALLUVIAL STRATIGRAPHY|DISCHARGE VARIABILITY|PALEOENVIRONMENTAL RECONSTRUCTIONS|MODEL SIMULATIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2455,"idioma_id":4,"titulo":"Odorous secretions in anurans: morphological and functional assessment 1 of serous glands 2 as a source of volatile compounds in the skin of the treefrog Hypsiboas pulchellus 3 (Amphibia: Anura: Hylidae)","resumen":"Serous (granular or venom) glands occur in the skin of almost all species of adult amphibians, and arethought to be the source of a great diversity of chemical compounds. Despite recent advances in theirchemistry, odorous volatile substances are compounds that have received less attention, and until now nostudy has attempted to associate histological data with the presence of these molecules in amphibians, or inany other vertebrate. Given the recent identification of 40 different volatile compounds from the skinsecretions of H. pulchellus (a treefrog species that releases a strong odour when handled), we examined thestructure, ultrastructure, histochemistry, and distribution of skin glands of this species. Histological analysisfrom six body regions reveals the presence of two types of glands that differ in their distribution. Mucousglands are homogeneously distributed, whereas serous glands are more numerous in the scapular region.Ultrastructural results indicate that electron-translucent vesicles observed within granules of serous glands aresimilar to those found in volatile-producing glands from insects and also with lipid vesicles from differentorganisms. Association among lipids and volatiles is also evidenced from chemical results, which indicate thatat least some of the volatile components in H. pulchellus probably originate within the metabolism of fattyacids or the mevalonate pathway. As odorous secretions are often considered to be secreted under stresssituations, the release of glandular content was assessed after pharmacological treatments, epinephrineadministrated in vivo and on skin explants, and through surface electrical stimulation. Serous glandsresponded to all treatments, generally through an obvious contraction of myoepithelial cells that surroundtheir secretory portion. No response was observed in mucous glands. Considering these morpho-functionalresults, along with previous identification of volatiles from H. pulchellus and H. riojanus after electricalstimulation, we suggest that the electron-translucent inclusions found within the granules of serous glandslikely are the store sites of volatile compounds and\/or their precursors. Histochemical and glandulardistribution analyses in five other species of frogs of the hylid tribe Cophomantini, revealed a high lipidcontent in all the species, whereas a heterogeneous distribution of serous glands is only observed in speciesof the H. pulchellus group. The distribution pattern of serous glands in members of this species group, andthe odorous volatile secretions are probably related to defensive functions.","palabras_clave":"Anura|Hylidae"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2456,"idioma_id":5,"titulo":"Descripción botánica y registro de TUC 95-37, nueva variedad de caña de azúcar (Saccharum spp.), en el Registro Nacional de Propiedad de Cultivares de la República Argentina","resumen":"This paper reveals the results of studies conducted to evaluate the productivity and response to diseases of TUC 95-37, a new sugarcane (Saccharum spp) cultivar obtained and selected by Sugarcane Breeding Program of Estación Experimental Agroindustrial Obispo Colombres. The data shown in this work derived from 24 harvesting sessions in trials with 17 genotypes, planted according to a completely randomized block design with three repetitions, with replicates at six different sites in Tucumán. TUC 95-37 was assessed at four different crop ages (plant cane, first, second and third ratoons), through the 2002 and 2005 crop seasons. Studies of its productivity (crop yield, percentage of factory yield in May and sugar production per ha) showed that TUC 95-37 was  similar to that of LCP 85-384 in most of the crop ages and sites considered. GGE biplot methodology was used as a graphic tool to identify superior and stable cultivars in different environments. TUC 95-37 turned out to be the best or most productive among genotypes and a very stable variety at plant cane, also ranking as the second best variety, as well as a very stable one, at first and second ratoon ages. However at third ratoon, TUC 95-37 showed lower stability in different environments. As regards its response to diseases, this new cultivar proved to be moderately resistant to brown rust (Puccinia melanocephala), leaf scald (Xanthomonas albilineans), and smut (Sporisorium scitamineum), but moderately susceptible to mosaic (Sugarcane mosaic virus) and red stripe (Acidoborax avenae). As most sugarcane varieties planted in other parts of the world, TUC 95-37 was susceptible to ratoon stunting disease (Leifsonia xyli subsp. xyli).","palabras_clave":"REGISTRO DE VARIEDADES|DESCRIPCIÓN BOTÁNICA|CAÑA DE AZÚCAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2458,"idioma_id":4,"titulo":"The Effector Protein BPE005 from Brucella abortus Induces Collagen Deposition and Matrix Metalloproteinase 9 Downmodulation via Transforming Growth Factor &#946;1 in Hepatic Stellate Cells","resumen":"The liver is frequently affected in patients with active brucellosis. In the present study, we identified a virulence factor involved in the modulation of hepatic stellate cell function and consequent fibrosis during Brucella abortus infection. This study assessed the role of BPE005 protein from B. abortus in the fibrotic phenotype induced on hepatic stellate cells during B. abortus infection in vitro and in vivo. We demonstrated that the fibrotic phenotype induced by B. abortus on hepatic stellate (LX-2) cells was dependent on BPE005, a protein associated with the type IV secretion system (T4SS) VirB from B. abortus. Our results indicated that B. abortus inhibits matrix metalloproteinase 9 (MMP-9) secretion through the activity of the BPE005-secreted protein and induces concomitant collagen deposition by LX-2 cells. BPE005 is a small protein containing a cyclic nucleotide monophosphate binding domain (cNMP) that modulates the LX-2 cell phenotype through a mechanism that is dependent on the cyclic AMP (cAMP)\/protein kinase A (PKA) signaling pathway. Altogether, these results indicate that B. abortus tilts LX-2 cells to a profibrogenic phenotype employing a functional T4SS and the secreted BPE005 protein through a mechanism that involves the cAMP and PKA signaling pathway.","palabras_clave":"TFSS|MMP9|brucella|pathogenesis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2460,"idioma_id":4,"titulo":"(-)-Epicatechin prevents alterations in the metabolism of superoxide anion and nitric oxide in the hearts of L-NAME-treated rats.","resumen":"The aim of this work was to evaluate the effects of (-)-epicatechin administration in the heart of a rat model with reduced NO production that follows a short-term treatment with L-NAME. Sprague-Dawley rats were treated for 4 d with L-NAME in the absence or presence of (-)-epicatechin in the diet. The redox status in cardiac tissue was improved by (-)-epicatechin administration. L-NAME treatment induced a decrease in NO synthase activity (-62%, p<0.05) and an increase in NADPH-dependent superoxide anion production (+300%, p<0.05) that were totally prevented by (-)-epicatechin administration. These effects of (-)-epicatechin were associated with a higher endothelial NO synthase phosphorylation at an activation site and a reduced expression of the regulatory subunit, p47phox, suggesting the involvement of posttranslational mechanisms in (-)-epicatechin action. Thus, the (-)-epicatechin treatment would restore NO steady state levels in vivo through effects on both, its synthesis and degradation via the reaction with superoxide anion. The fact that (-)-epicatechin is commonly present in human diet makes this compound a reasonable explanation for the positive cardiovascular effects of a high consumption of fruits and vegetables.","palabras_clave":"superoxide|nitric oxide|flavonoids|heart"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2461,"idioma_id":4,"titulo":"Functional Role of Water in Membranes Updated: A Tribute to Träuble","resumen":"The classical view of a cell membrane is as a hydrophobic slab in which  only nonpolar solute can dissolve and permeate. However, water  soluble non-electrolytes such as glycerol, erythritol, urea and others can  permeate lipid membranes in the liquid crystalline state. Moreover,  recently polar amino acid?s penetration has been explained by means of  molecular dynamics in which appearance of water pockets is  postulated.  According to Träuble (1971), water diffuses across the lipid membranes  by occupying holes formed in the lipid matrix due to fluctuations of the  acyl chain trans-gauche isomers. These holes, named ?kinks? have the  molecular dimension of CH2 vacancies. The condensation of kinks may  form aqueous spaces into which low molecular weight species can  dissolve. This molecular view can explain permeability properties  considering that water may be distributed along the hydrocarbon  chains in the lipid matrix.  The purpose of this review is to consolidate the mechanism anticipated  by Träuble by discussing recent data in literature that directly  correlates the molecular state of methylene groups of the lipids with the  state of water in each of them. In addition, the structural properties of  water near the lipid residues can be related with the water activity  triggering of kink formation by changes in the head group conformation  that induces the propagation of kinks along the acyl chains and hence to  the diffusion of water.","palabras_clave":"LIPID MEMBRANES|PERMEABILITY|WATER DIFFUSION|KINKS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2462,"idioma_id":5,"titulo":"Reconstrucción estructural de una sección de la Precordillera occidental argentina (31º08?LS-69º24?LO) a partir de datos aeromagnéticos","resumen":"Se presenta el perfil de anomalía magnética realizado a lo largo de una sección estructural NESO (31º08´LS - 69º24´LO) en el borde occidental de la Precordillera Argentina. Mediante la aplicación de cocientes entre bandas se procesaron imágenes satelitales Landsat 7 ETM+ y se procesaron datos aeromagnéticos según los métodos de filtrado (calculo de anomalía magnética residual) y resalto de anomalía magnética (señal analítica, tilt y la derivada horizontal del tilt). Se reconocieron dos litofacies dentro de la Formación Don Polo (litofacies I ala base y II hacia el techo de la secuencia). La estructura principal de la sierra de Villa Corral está definida por un pliegue sinclinal con eje buzante al SE y pliegues similares de menor escala asociados, que en conjunto son fragmentados por dos sistemas de corrimientos: uno Pre-Andino orientado NO-SE con planos de falla inclinado al NE y movimiento de techo al SO; otro Andino, con rumbo N-S y plano de falla inclinado al O con movimiento de techo al E. La carta de señal analítica y su representación en perfil demuestra la importancia de los contrastes magnéticos producidos por los corrimientos principales, al mismo tiempo permite ajustar la distribución de unidades en subsuelo de acuerdo al desplazamiento relativo de los bloques de falla.","palabras_clave":"magnetico|geofísico|filtros|estructura"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2463,"idioma_id":4,"titulo":"Development and Validation of a Dissolution Test method for Albendazole and Praziquantel in their Combinaded Dosage Form","resumen":"A dissolution test method and an analytical procedure by HPLC were developed and validated for the evaluation of the dissolution of tablets containing albendazole and praziquantel. Two differentcommercially tablets containing 500  mg of albendazole and 50 mg of praziquantel for veterinary use were selected for this study. A dissolution medium containing a mixture of 300 mL ethanol and 600 mL of 0.1 mol L-1 HCl was found suitable to ensure sink conditions. USP Apparatus 2, 900 mL dissolution medium and 75 rpm were fixed. Dissolution profiles were generated at 45 min.Dissolution samples were analyzed with a reversed-phase high-performance liquid chromatography (RP-HPLC) method with ultraviolet (UV) detection at 210 nm, developed and validated for this purpose. Each product was also assayed for analyte content according to USP 35. The dissolution test described here could be proposed as a means of assessing finished product quality.","palabras_clave":"DEVELOPMENT|DISSOLUTION|ALBENDAZOLE|PRAZIQUANTEL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2465,"idioma_id":4,"titulo":"Determination of thimerosal in pharmaceutical industry effluents andriver waters by HPLC coupled to atomic fluorescence spectrometrythrough post-column UV-assisted vapor generationGimena","resumen":"tA high performance liquid chromatography coupled with atomic fluorescence spectrometry methodfor the determination of thimerosal (sodium ethylmercury thiosalicylate, C9H9HgNaO2S), ethylmercury,and inorganic mercury is proposed. Mercury vapor is generated by the post-column reduction of mercuryspecies in formic acid media using UV-radiation. Thimerosal is quantitatively converted to Hg(II) followedby the reduction of Hg(II) to Hg(0). This method is applied to the determination of thimerosal (THM),ethylmercury (EtHg) and inorganic Hg in samples of a pharmaceutical industry effluent, and in waters ofthe San Luis River situated in the west side of San Luis city (Middle West, Argentine) where the effluentsare dumped. The limit of detections, calculated on the basis of the 3 criterion, where 0.09, 0.09 and0.07 g L&#8722;1for THM, EtHg(II) and for Hg(II), respectively. Linearity was attained from levels close to thedetection limit up to at least 100 g L&#8722;1.","palabras_clave":"THIMEROSAL, ETHYLMERCURY AND MERCURYDETERMINATION|PHARMACEUTICAL INDUSTRY EFFLUENTS|LIQUID CHROMATOGRAPHY|UV-CV-AFS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2466,"idioma_id":5,"titulo":"Competencia social y status  sociométrico escolar en niños con diagnóstico de Trastorno por déficit de atención e   hiperactividad (TDAH)","resumen":"Objetivo: Establecer relaciones entre la autopercepción de la competencia social en niños con TDAH y el status sociométrico escolar. Alcance: Los resultados obtenidos permitirán elaborar estrategias de intervención psicológica como así también el diseño de abordajes educativos en el aula que fortalezcan la interacción social de estos niños. Metodología: Estudio descriptivo correlacional con un diseño ex post facto retrospectivo (Montero & León, 2007). La muestra estuvo compuesta por 157 niños con edades comprendidas entre 8 y 12 años. Se conformaron dos grupos, clínico (n=5) y control (n=152), pareados por edad. Se administró el cuestionario MESSY (Matson, Rotatori & Helsel 1983) y el Test sociométrico (Moreno, 1962). Resultados: Los niños con TDAH son menos asertivos que los niños del grupo control. La mayoría presenta una posición aislada con respecto a su grupo de pares. Conclusiones: Estos niños presentan dificultad para establecer relaciones vinculares con sus compañeros. No obstante la autopercepción de sus competencias sociales no coincide en todos los casos con su status sociométrico escolar.","palabras_clave":"INFANCIA |RELACIONES INTERPERSONALES|TDAH|COMPETENCIA SOCIAL|STATUS SOCIOMÉTRICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2467,"idioma_id":4,"titulo":"Fruit infestation patterns by Anastrepha fraterculus and Ceratitis capitata reveal that cross&#8208;recognition does not lead to complete avoidance of interspecific competition in nature","resumen":"The avoidance of parasitized or infested hosts, which is a common phenomenon in parasitic wasps and phytophagous insects, may act both intra- and interspecifically. Most studies on chemically-mediated avoidance of interspecific competition in insects have been conducted at the individual level. The role of this behaviour on the spatial distribution of offspring of sympatric species with overlapping host ranges has been overlooked.  In the present study, two analytical approaches were used to investigate the co-infestation patterns of the fruit flies Anastrepha fraterculus (Wiedemann) (Diptera: Tephritidae) and Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), aiming to unravel the importance of cross-species infestation recognition in nature.  Guava fruit were sampled in an area of coexistence of these two fruit flies and individually categorized as non-infested, infested by one of the species or infested by both species. The frequency of each type of fruit was compared with the frequency distributions expected under two models: an independent oviposition model and a competition avoidance model. As an alternative approach, co-occurrence patterns were evaluated using null models.  The results showed that avoidance of competition could be occurring in nature, although only in a few cases in which infestation levels are moderate. The two approaches revealed that the spatial scale has significant impact on the resulting co-occurrence patterns, such that opposite behaviours towards infested fruit are inferred at the largest (mainly aggregated oviposition pattern) versus the smallest scale (mainly independent oviposition pattern).  For the system under investigation, our findings suggest that the avoidance of infested fruit does not contribute, or at least not strongly, to the coexistence of the two species.","palabras_clave":"OVIPOSITION DETERRENT PHEROMONE|HOST MARKING PHEROMONE|ECOSIM|FORAGING BEHAVIOUR|COEXISTENCE|FEMALE HOST CHOICE|BIOLOGICAL INVASION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2468,"idioma_id":4,"titulo":"Safety and immunogenicity of a soluble native Neospora caninum tachyzoite-extract vaccine formulated with a soy lecithin\/&#946;-glucan adjuvant in pregnant cattle","resumen":"The global economic impact of Neospora caninum infection in cattle herds   has promoted the development of vaccines that can be safely used during   pregnancy. The aim of this study was to evaluate the safety and   immunogenicity of a vaccine formulated with the soluble fraction of   tachyzoite´s lysate and a soy-based aqueous adjuvant (sNcAg\/AVEC), which   was protective in the mouse model and induced strong IFN-&#947; responses   and high avidity antibodies in non-pregnant cattle. Ten pregnant heifers   were vaccinated twice during the first trimester of gestation and 8   remained unvaccinated. Anti-N. caninum immune responses were efficiently   primed by vaccination, evidenced by a quick induction of IgM serum   titers (7dpv) and a prompt switch to high avidity IgG shortly after   infection (performed at 78 or 225 days of gestation; n=5 each); while   naïve cattle elicited lower IgG titers, with a delayed kinetics. High   systemic IFN-&#947; levels were induced after infection which did not   interfere with pregnancy. No local or systemic adverse effects were   recorded along the study. Calves were born in term and in good health   conditions, showing that the sNcAg\/AVEC vaccine was safe when applied to   healthy heifers during the first trimester of gestation.","palabras_clave":"Neospora caninum|Immunity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2469,"idioma_id":4,"titulo":"Large scale distribution of ultra high energy cosmic rays detected at the Pierre Auger Observatory with zenith angles up to 80","resumen":"We present the results of an analysis of the large angular scale distribution of the arrival directions of cosmic rays with energy above 4 EeV detected at the Pierre Auger Observatory including for the first time events with zenith angle between 60º and 80º. We perform two Rayleigh analyses, one in the right ascension and one in the azimuth angle distributions, that are sensitive to modulations in right ascension and declination, respectively. The largest departure from isotropy appears in the E > 8 EeV energy bin, with an amplitude for the first harmonic in right ascension (4.4±1.0)x10^-2, that has a chance probability P = 6.4x10^-5, reinforcing the hint previously reported with vertical events alone.","palabras_clave":"ASTROPARTICLE PHYSICS|COSMIC RAYS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2470,"idioma_id":4,"titulo":"Hydrogen Adsorption and Associated Electronic and Magnetic 2 Properties of Rh-Decorated (8,0) Carbon Nanotubes Using Density 3 Functional Theory","resumen":"A systematic spin-polarized density functional theory (DFT) study of hydrogen interaction with pristine and Rh-decorated zigzag (8,0) single-walled carbon nanotubes (SWCNTs) was performed. The most stable decoration site for Rh atoms as well as atomic and molecular hydrogen adsorption inside and outside the SWCNT was studied. Hydrogen adsorption energy in Rh-decorated SWCNTs was improved compared to that of pristine nanotubes. In addition, Rh-decorated SWCNT systems present a magnetic moment. Density of states and work function (WF) were computed to study the bonding evolution and electronic structure. When hydrogen is considered on Rh-SWCNT and pristine SWCNT, the WF increased while band gap decreased compared to that of pristine SWCNT.","palabras_clave":"zig-zag CNT|adsorption|Hydrogen storage|spintronics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2471,"idioma_id":4,"titulo":"Identification of carbon-based black pigments in four South American polychrome        wooden sculptures by Raman microscopy","resumen":"Introduction: Carbon-basedpigments are a group of dark-colored materials, which are classified accordingto the starting material used and their manufacturing process. Ramanspectroscopy is an ideal technique for the identification of carbonaceousmatter. Carbon-based pigments show broad bands between 1300 and 1600 cm-1but they differ in position, width and relative intensity, allowingdiscrimination between them. The aim of the present study was theidentification of carbon-based pigments in four polychrome wooden sculptures from theJesuit Mission La Trinidad in Paraguay.Results:Analysis of the Raman spectral parameters of the polychrome samples andcomparison with those of carbon-based pigment references allowed theidentification of wood charcoal, lampblack, bistre and a black earth pigment.Complementary analysis by infrared spectroscopy and elemental analysissupported the assignments. &nbsp;Conclusions: Inthis study we have provided newevidence that Raman microscopy is a powerful technique for the discriminationof carbon-based pigments in works of art. This is the first time that bistre,lampblack and a black earth pigment are identified in colonial art. Thechemical information obtained on the black pigments contributed to increase ourknowledge on available resources and technology used in the manufacture of thepolychrome sculptures at the Jesuit Mission. This information is relevant forour studies on Colonial art.Keywords: Carbon-basedpigments; Raman microscopy; Polychrome sculpture; Colonial art; SEM-EDS; FT-IR","palabras_clave":"CARBON-BASED PIGMENTS|RAMAN MICROSCOPY|POLYCHROME SCULPTURE|COLONIAL ART|SEM-EDS|FT-IR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2473,"idioma_id":4,"titulo":"Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome.","resumen":"AbstractHaemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of classical and alternative pathways of complement during the acute phase of Shiga toxin-associated HUS by performing a prospective study of 18 patients and 17 age-matched healthy controls to evaluate C3, C3c, C4, C4d, Bb and SC5b-9 levels. SC5b-9 levels were increased significantly in all patients at admission compared to healthy and end-stage renal disease controls, but were significantly higher in patients presenting with oliguria compared to those with preserved diuresis. C3 and C4 levels were elevated significantly at admission in the non-oliguric group when compared to controls. No significant differences were found for C4d values, whereas factor Bb was elevated in all patients and significantly higher in oliguric patients when compared to both controls and non-oliguric individuals. A positive and significant association was detected when Bb formation was plotted as a function of plasma SC5b-9 at admission. Bb levels declined rapidly during the first week, with values not significantly different from controls by days 3 and 5 for non-oligurics and oligurics, respectively. Our data demonstrate the activation of the alternative pathway of complement during the acute phase of Stx-associated HUS. This finding suggests that complement activation may represent an important trigger for the cell damage that occurs during the syndrome.","palabras_clave":"acute renal injury; | alternative pathway|complement"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2474,"idioma_id":4,"titulo":"Survival, growth and vulnerability to drought in fire refuges: implications for the persistence of a fire&#8209;sensitive conifer in northern Patagonia","resumen":"Fire severity and extent are expected to increase in many regions worldwide due to climate change. Therefore, it is crucial to assess the relative importance of deterministic vs. stochastic factors producing remnant vegetation to understand their function in the persistence of fire-sensitive plants. Vegetation remnants (areas within the landscape that have not burned for a considerable amount of time) may occur stochastically or in more predictable locations (fire refuges) where physical conditions decrease fire severity. Our aim was to determine if remnant forests of the fire-sensitive conifer Austrocedrus chilensis are associated with biophysical attributes that allow persistence in a fire-prone Patagonian landscape. We conducted a multiscale approach, determining attributes of forest remnants and their surroundings (matrices) through remote sensingand field-based biophysical and functional characteristics, and quantifying how tree survival probability relates to microsite conditions. Trees within remnants displayed abundant fire scars, were twofold older and had threefold larger growth rates than matrix trees. Remnants were associated with high rocky cover and elevated topographical positions. Tree survival increased in hilltops, eastern aspects, and with sparse vegetation. Trees within remnants experienced severe reductions in growth during droughts. Our results suggest that A.  chilensis remnants are mainly the result of refuges, where environmental conditions increase fire survival, but also increase susceptibility todrought. A trade-off between fire survival and drought vulnerability may imply that under increasing drought and fire severity, locations that in the past have served as refuges may reduce their ability to allow the persistence of fire-sensitive taxa.","palabras_clave":"Basal area increment|Forest remnant|Climate change|Biophysical attributes|Austrocedrus chilensis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2478,"idioma_id":5,"titulo":"Impacto y Potencial delos recursos educativos abiertos (REA) en los procesos de enseñanza-aprendizaje en modalidad virtual en las carreras de grado de Ciencias Económicas de la Universidad Nacional de la Matanza 2014-2015","resumen":"Esta ponencia presenta el estado de avance del presente proyecto de investigación continúa la línea de investigación del  proyecto CyTMA2-ECO 005: El acceso a los recursos de información en  Ciencias Económicas disponibles en Internet, y su impacto en los procesos de  enseñanza-aprendizaje en las carreras de grado en Ciencias Económicas en la  Universidad Nacional de la Matanza 2012-2013, que a su vez continúa el  trabajo con el que se inició esta línea mediante el proyecto PICE-013: Difusión  y visibilidad del conocimiento producido en las Ciencias Económicas en  ambientes virtuales en la Argentina 2010-2011, en el cual en una primera  aproximación al tema se indagó acerca de los recursos de información en  Ciencias Económicas consultados por alumnos de las carreras en Ciencias  Económicas de la UNLaM mediante una encuesta presencial de carácter  restringido, comparando dichos resultados con los obtenidos por profesionales  en Ciencias Económicas, y estableciendo finalmente un ranking de la calidad  de los recursos consultados mediante una aplicación de una herramienta  informática cibermétrica de acceso libre (Xenu). En el proyecto CyTMA2  antecedente se amplió el alcance del proyecto anterior abarcando un estudio  de campo que incluyó una muestra de alumnos y docentes de asignaturas de  carreras de Ciencias Económicas, estableciendo la incidencia que presenta el  uso de estos recursos en los procesos de enseñanza aprendizaje, así como  también en la transferencia de los productos de conocimiento de la  investigación producidos en la UNLaM hacia las carreras de grado en Ciencias  Económicas. En el actual proyecto se indaga acerca del impacto y potencial  que presentan los recursos educativos abiertos (REA) en la creación, difusión,  modificación y reutilización de componentes (módulos teóricos, artículos de  investigación, actividades prácticas, exámenes, cuestionarios, videos, etc.)  que participan en los procesos de enseñanza-aprendizaje en modalidad virtual  en las carreras de grado de Ciencias Económicas de la UNLaM. Para ello se  está realizando un estudio descriptivo de las características que presenta la  enseñanza virtual en la UNLaM mediante la plataforma MIeL (Materias Interactivas en Línea) en las carreras de grado en Ciencias Económicas, y la  integración en dicha modalidad de los REA. Se encuentra bajo desarrollo un  trabajo empírico que releva las estrategias didácticas implementadas en las  materias dictadas en modalidad virtual, y se aplicarán encuestas a alumnos y  docentes en una muestra seleccionada a partir del total de la oferta de  asignaturas en modalidad virtual que se dictan en las carreras de grado del  Departamento de Ciencias Económicas en la UNLaM. Los resultados a alcanzar  permitirían establecer la factibilidad de aplicación en un corto plazo de los REA  y en relación a dicha oferta académica.","palabras_clave":"RECURSOS|EDUCACIÓN|INTERNET"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2481,"idioma_id":5,"titulo":"Evaluación de reportes de sustentabilidad. Informes sobresalientes 2015","resumen":"En el año 2015 el equipo de evaluadores de la Revista Mercado analizó 58 reportes de sustentabilidad (37 el año anterior). El artículo da cuenta de los resultados del análisis, destacando como primeras comprobaciones surgidas: la profundidad que exhibe esta rendición de cuentas con respecto a versiones anteriores, el espacio ganado por los indicadores GRI y la tendencia a una mayor integración con los datos financieros.","palabras_clave":"REPORTE|INFORMACION NO FINANCIERA|SUSTENTABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2586,"idioma_id":4,"titulo":"Late Aptian angiosperm pollen grains from Patagonia: Earliest steps in flowering plant evolution at middle latitudes in southern South America","resumen":"The angiosperm pollen record from the Anfiteatro de Tico and Punta del Barco formations (BaqueroGroup) is reported. The relevance of these floras is that they are accurately dated as late Aptian, and oneof the oldest floras southern South America with fossil angiosperms. Twelve samples were studied,showing Clavatipollenites and Retimonocolpites as dominant types. A new species, Jushingipollis ticoensissp. nov., is proposed. A doubtful angiosperm pollen grain, Lethomasites sp., is also identified anddescribed. A multivariate analysis of similarities between different Early Cretaceous angiosperm pollenassemblages suggests that the Baquero Group assemblages have great similarities with other coeval unitsfrom Argentina, Australia and United States, which were located in a similar paleolatitude.","palabras_clave":"Palynology|Angiosperm|Late Aptian|Baqueró Group"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2587,"idioma_id":5,"titulo":"RESTOS ÓSEOS HUMANOS Y FAUNÍSTICOS: SU RELACIÓN EN EL ESPACIO MORTUORIO EN CONTEXTOS DE CAZADORES-RECOLECTORES DEL HUMEDAL DEL PARANÁ INFERIOR (ARGENTINA)","resumen":"Los entierros de restos faunísticos y humanos en forma conjunta es una característica mundialmente conocida y ha sido interpretada desde diferentes ópticas, señalando vínculos sociales y simbólicos entre ambos como, por ejemplo, situaciones de animismo y connotaciones de prestigio. En el extremo meridional de humedal del Paraná inferior los contextos mortuorios suelen caracterizarse por la presencia de numerosos restos faunísticos, fragmentos cerámicos y artefactos (óseos y líticos) esparcidos tanto por encima como por debajo de las inhumaciones humanas. En trabajos que datan de principios del siglo XX esta relación entre elementos cotidianos y entierros fue señalada por algunos autores como producto de posibles rituales mortuorios. No obstante, existen ciertos elementos faunísticos que podrían estar transcendiendo dicha interpretación, conformando parte de lo que se conoce como acompañamiento mortuorio. En el área de estudio estas últimas interpretaciones han sido básicamente planteadas a partir de la presencia de cráneos y caninos modificados de carnívoros (cánidos y\/o félidos) asociados a las inhumaciones humanas. En tal sentido, el objetivo de este trabajo es analizar la información preexistente vinculada con estas asociaciones y dar a conocer nuevos datos al respecto a partir de los resultados obtenidos en recientes excavaciones. Finalmente, se evalúan y discuten las potenciales relaciones que pudieron existir entre ciertos fenómenos ideacionales, los entierros humanos y los elementos faunísticos utilizados como acompañamiento mortuorio.","palabras_clave":"CARNIVOROS|ENTIERROS HUMANOS|ANIMISMO|PARANA INFERIOR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2590,"idioma_id":4,"titulo":"Population genetic structure and body shape assessment of Pagrus pagrus (Perciformes: Sparidae) from Buenos Aires coast of the Argentine Sea (aceptado)","resumen":"This study includes the analysis of the morphological and genetic variation of the common sea bream, it compares two main areas of concentration, the northern one (35ºS- 38°S) and the southern (39°S- 41°S) in the Buenos Aires coastline of the Argentinean Sea. La caracterización de la forma del cuerpo mostró dos morfotipos diferenciados significativamente (Wilks´ Lambda= 0.224, PThe body shape characterization presented two significantly different morphotypes (Wilks´Lambda=0.224, PLas zonas no presentaron diferencias genéticas significativas, tanto para la región control (&#61542;ST =0.025) como para los loci microsatélites (FST= 0.007).The zones did not show significant genetic differences, not even at the control region or the microsatellites loci.Si bien este estudio reveló que el besugo no está estructurado genéticamente indicando la presencia de una sola ?población? panmíctica, la variación fenotípica en los patrones morfológicos entre ambas zonas definiría, como enfoque precautorio para la especie recurso, dos unidades de manejo en la costa bonaerense.Even though this study has revealed that the common sea bream is not genetically structured showing the presence of just one panmictic population; the phenotypic variation in the morphological patterns between both zones would define, as precautionary approach for Pagrus pagrus two management units in the Buenos Aires coastline.","palabras_clave":"morfometría geometrica|microsatelites|ADN mitocondrial|Stocks pesqueros"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2591,"idioma_id":4,"titulo":"Metabolic analyses of interspecific tomato recombinant inbred lines for fruit quality improvement","resumen":"Elucidating the determinants of tomato nutritional  value and fruit quality to introduce improved varieties  on the international market represents a major  challenge for crop biotechnology. Different strategies can  be undertaken to exploit the natural variability of Solanum  to re-incorporate lost allelic diversity into commercial varieties.  One of them is the characterization of selected  germplasm for breeding programs. To achieve this goal, 18  RILs (S. lycopersicum 9 S. pimpinellifolium) were comprehensively  phenotyped for fruit polar metabolites and  quality associated traits. Metabolites were quantified by  GC?MS and 1H NMR. Integrative analyses by neuronal clustering and network construction revealed that fruit  properties are strongly associated with the metabolites aspartate,  serine, glutamate and 2-oxoglutarate. Shelf life and  firmness appeared to be linked to malate content. By a  comparative analysis of the whole data set, ten RILs presented  higher number of traits with positive effect than the  S. lycopersicum 9 S. pimpinellifolium hybrid. Thus, these  lines can be proposed as promising candidates for breeding  programs aimed to improve fruit quality.","palabras_clave":"Tomato|Fruit quality|Solanum lycopersicum|Metabolomics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2593,"idioma_id":4,"titulo":"Over-production of altered VLDL in an insulin-resistance rat model: influence of SREBP-1c and PPAR-&#945;","resumen":"Background: In insulin-resistance, VLDL presents alterations that increase its atherogenicpotential. The mechanism by which insulin-resistance promotes the production of altered VLDLis still not completely understood. The aim of this study was to evaluate the relationshipbetween the expression of sterol regulatory element binding protein 1c (SREBP-1c) and of per-oxisome proliferator-activated receptor-a (PPAR-a), with the features of composition and sizeof VLDL in an insulin-resistance rat model induced by a sucrose rich diet (SRD).Methods: A study was conducted on 12 male Wistar rats (180 g) receiving SRD (12 weeks) and12 controls. Lipid profile, free fatty acids, glucose, and insulin were measured. Lipid contentin liver and visceral fat was assessed. Isolated VLDL (d chemical composition and size by HPLC. The respective hepatic expression of SREBP-1c andPPAR-a was determined (Western blot). Results: As expected, SRD had elevated triglycerides (TG), free fatty acids and insulin levels,and decreased HDL-cholesterol (p (p Conclusions: Insulin-resistance, by coordinated activation of SREBP-1c and reduction of PPAR-a, could promote the secretion of larger and TG over-enriched VLDL particles, with greater atherogenic capacity.","palabras_clave":"Insulin-resistance|Sucrose rich diet|SREBP-1c| PPAR-a|Large VLDL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2597,"idioma_id":4,"titulo":"Chia seed oil-in-water emulsions as potential delivery systems of x-3 fatty acids","resumen":"Chia oil can be incorporated into oil-in-water (O\/W) emulsions as x-3 fatty acid delivery systems in food  matrices. Chia O\/W emulsions varying in sodium caseinate (NaCas) concentration (2, 5 and 10% (wt\/wt)),  with and without 10% (wt\/wt) lactose and using different homogenization pressures (400, 600 bar) were  prepared, stored at 4 ± 1 C and analyzed as a function of particle size, f-potential, rheological properties,  backscattering profiles, peroxide and p-anisidine values. Droplet characteristics, rheology and stability of  emulsions are influenced with different extent by the factors analyzed. All systems recorded negatively  charged droplets and unimodal particle size distribution. Emulsions with 2 and 5% (wt\/wt) NaCas presented  a Newtonian fluid behavior. The former showed moderate stability to creaming, while the latter  presented destabilization by flocculation and creaming few hours after preparation. Emulsions with 10%  (wt\/wt) NaCas showed a pseudoplastic fluid behavior and high stability by the rearrangement of the  aggregates into a firm gel network. Chia O\/W emulsions exhibited a good oxidative stability.","palabras_clave":"Chia|Emulsiones|Acidos grasos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2598,"idioma_id":4,"titulo":"Large perpendicular magnetic anisotropy in magnetostrictive Fe1&#8722;xGax thin films","resumen":"In this work we report the appearance of a large perpendicular magnetic anisotropy (PMA) in Fe1-xGax thin films grown onto ZnSe\/GaAs(001). This arising anisotropy is related to the tetragonal metastable phase in as-grown samples recently reported [M. Eddrief, Phys. Rev. B 84, 161410 (2011)PRBMDO1098-012110.1103\/PhysRevB.84.161410]. By means of ferromagnetic resonance studies we measured PMA values up to &#8764;5×105 J\/m3. PMA vanishes when the cubic structure is recovered upon annealing at 300°C. Despite the important values of the magnetoelastic constants measured via the cantilever method, the consequent magnetoelastic contribution to PMA is not enough to explain the observed anisotropy values in the distorted state. Ab initio calculations show that the chemical ordering plays a crucial role in the appearance of PMA. Through a phenomenological model we propose that an excess of next-nearest-neighbor Ga pairs (B2-like ordering) along the perpendicular direction arises as a possible source of PMA in Fe1-xGax thin films.","palabras_clave":"magnetic anisotropy|magnetostriction|Ga dimmers"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2599,"idioma_id":4,"titulo":"Destabilization of the torsioned conformation of a ligand side chain inverts the LXR&#946; activity","resumen":"Liver X receptors (LXRs) are transcription factors activated by cholesterol metabolites containing an oxidized side chain. Due to their ability to regulate lipid metabolism and cholesterol transport, they have become attractive pharmacological targets. LXRs are closely related to DAF-12, a nuclear receptor involved in nematode lifespan and regulated by the binding of C-27 steroidal acids. Based on our recent finding that the lack of the C-25 methyl group does not abolish their DAF-12 activity, we evaluated the effect of removing it from the (25R)-cholestenoic acid, a LXR agonist.METHODS:The binding mode and the molecular basis of action of 27-nor-5-cholestenoic acid were evaluated using molecular dynamics simulations. The biological activity was investigated using reporter gene expression assays and determining the expression levels of endogenous target genes. The in vitro MARCoNI assay was used to analyze the interaction with cofactors.RESULTS:27-Nor-5-cholestenoic acid behaves as an inverse agonist. This correlates with the capacity of the complex to better bind corepressors rather than coactivators. The C-25 methyl moiety would be necessary for the maintenance of a torsioned conformation of the steroid side chain that stabilizes an active LXR&#946; state.CONCLUSION:We found that a 27-nor analog is able to act as a LXR ligand. Interestingly, this minimal structural change on the steroid triggered a drastic change in the LXR response.GENERAL SIGNIFICANCE:Results contribute to improve our understanding on the molecular basis of LXR&#946; mechanisms of action and provide a new scaffold in the quest for selective LXR modulators.","palabras_clave":"LXR|oxiesteroles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2679,"idioma_id":5,"titulo":"Inversión multiimplantada: Tierras, comercio y finanzas en la Patagonia Austral","resumen":"Se analiza en este trabajo la conformación y desarrollo de una empresa familiar, la Sociedad Anónima Exportadora e Importadora de la Patagonia ?más conocida como ?La Anónima?-, una de las firmas supermercadistas más importantes del país en la actualidad. Constituida en el año 1908 por capitales instalados en la ciudad puerto de Punta Arenas, en el sector chileno del estrecho de Magallanes, ?La Anónima? basó su estrategia de crecimiento económico en una clara expansión de sus actividades en toda el área sur del continente, nacionalizándose por diversos motivos como empresa argentina en el año 1918. Su evidente política económica de inversiones simultáneas ampliamente diversificadas, tanto en la ocupación de tierras para la producción ganadera como en la creación de establecimientos comerciales en las localidades más importantes de la Patagonia -hoy extendida a varios puntos del conjunto nacional-, así como en la operación de los primeros frigoríficos ovinos, sumadas a sus actividades bursátiles y financieras, la convierten en un ejemplo ?tal vez el de mayor escala y sin duda el más exitoso- de este tipo de conductas empresariales de carácter familiar en el sur del país.","palabras_clave":"INVERSION|MULTIIMPLANTADA|PATAGONIA|AUSTRAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2682,"idioma_id":5,"titulo":"Territorios de violencia patriarcal: doce años de femicidios en Santiago del Estero (2002 ? 2014)","resumen":"Este trabajo se propone un acercamiento al fenómeno de la violencia extrema contra las mujeres (y mujeres trans) en Santiago del Estero. Para tal fin, se analiza una base de datos (2002-2014) que contiene la información de aquellas que fueron asesinadas y las características del crimen. Las fuentes consultadas para la construcción de la misma son dos periódicos locales. Luego para las comparaciones de alcance nacional se recurre a la información publicada por La Casa del Encuentro (ONG) que realiza esta tarea desde el año 2008. Santiago del Estero tiene la tasa de femicidios más alta del país y duplica a la media nacional. De modo que a partir de esta evidencia empírica se busca profundizar la comprensión. A su vez se presentan los marcos legales vigentes y una enumeración de las políticas públicas referidas a la violencia contra las mujeres desde los tres poderes de gobierno. Dentro del contexto histórico estructural santiagueño se proponen algunas hipótesis y finalmente se expone una aproximación a las teorías feministas que son claves para la comprensión de los fundamentos patriarcales que sostienen la subalternización femenina en nuestras sociedades.","palabras_clave":"Violencia|Mujeres|Modernidad|Femicidios"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2683,"idioma_id":5,"titulo":"Las situaciones escolares en escena: aportes a la formación docente en educación sexual integral","resumen":"Las situaciones escolares en escena: aportes a la formación docente eneducación sexual. En este escrito nos proponemos hacer un aporte a laformación docente en educación sexual integral, entendiendo a la sexualidad másallá de la genitalidad y la reproducción, contemplando que involucra relacionesde poder, identidades, emociones y placer. Atendiendo a la importancia delcurrículo oculto en la transmisión del sexismo y en la reproducción de lasdesigualdades de género, diseñamos un dispositivo para trabajar con lasintervenciones docentes ante los conflictos emergentes en la escuela,centrándonos en aquellos que se relacionan con los géneros y las sexualidades. Parala llevar a cabo este trabajo, se conformó una comunidad de práctica dedocentes de diferentes disciplinas de una escuela media de la provincia deBuenos Aires, Argentina. El dispositivo, basado en el teatro imagen, unavertiente del teatro del oprimido, nos permitió abordar las situacionesescolares con y desde los cuerpos exponiendo dimensiones de la sexualidadfrecuentemente silenciadas en la escuela. A partir de la escena propuesta, se logró que lxs docentes reflexionaran sobre las tensionesy significados que se le atribuyen al embarazo en la institución escolar. En unsentido más amplio, concluimos que este tipo de análisis puede ser uncamino para reflexionar sobre los roles y las relaciones de poder, aportando alxs profesionales de la educación nuevas herramientas ante las situaciones queirrumpen la vida de la escuela.","palabras_clave":"cuerpo|escuela|teatro del oprimido|educacion sexual"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2684,"idioma_id":4,"titulo":"Measurements of the Higgs boson production and decay rates and coupling strengths using pp collision data at s&#8730;=7 s 7  and 8 TeV in the ATLAS experiment","resumen":"Combined analyses of the Higgs boson production and decay rates as well as its coupling strengths to vector bosons and fermions are presented. The combinations include the results of the analyses of the H&#8594;&#947;&#947;,ZZ&#8727;,WW&#8727;,Z&#947;,bb¯,&#964;&#964;  decay modes, and the constraints on the associated production with a pair of top quarks and on the off-shell coupling strengths of the Higgs boson. The results are based on the LHC proton-proton collision datasets, with integrated luminosities of up to 4.7 fb&#8722; recorded by the ATLAS detector in 2011 and 2012. Combining all production modes and decay channels, the measured signal yield, normalised to the Standard Model expectation, is 1.18+0.15&#8722;0.14. The observed Higgs boson production and decay rates are interpreted in a leading-order coupling framework, exploring a wide range of benchmark coupling models both with and without assumptions on the Higgs boson width and on the Standard Model particle content in loop processes. The data are found to be compatible with the Standard Model expectations for a Higgs boson at a mass of 125.36 GeV for all models considered.","palabras_clave":"ATLAS|HIGH ENERGY PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2685,"idioma_id":5,"titulo":"El desarrollo local en el noreste de Misiones Argentina: una misión compartida","resumen":"El desarrollo local, es un proceso vinculado a un conjunto de capacidades, con foco en la relación de las personas y de las organizaciones públicas y privadas, también de la capacidad de articulación con el entorno.La zona bajo estudio, el municipio de Comandante Andresito (Noreste de la provincia de Misiones), se sustenta básicamente en la producción primaria, con gran crecimiento de la ganadería, yerba mate, palmito y otros productos anuales, pero con un alto porcentaje de pequeños productores (minifundistas) que trabajan la tierra en forma manual con escasa tecnología aplicada y la inclusión de mano de obra familiar incluso infantil, muchas dificultades para acceder a los mercados  altos niveles de necesidades básicas insatisfechas y escasa interrelación entre los actores locales.El objetivo de este trabajo, es generar un espacio de reflexión sobre la importancia de la articulación de todos los actores locales para generar desarrollo local y analizar cuál es el alcance de las intervenciones de la UNaM para la implementación de acciones conjuntas, tendientes a la resolución de problemas  socioeconómicos.","palabras_clave":"Desarrollo |produccion agropecuaria |recursos humanos|politicas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2687,"idioma_id":5,"titulo":"Desafíos y oportunidades del desarrollo de la electrónica de consumo en los países en desarrollo. Lecciones del caso Argentino en 2003-2014","resumen":"En América Latina, la mayor parte de los países son importadores netos de productos de electrónica de consumo y solo unos pocos países han logrado producir una porción significativa de los insumos y productos finales. El propósito del presente trabajo es elaborar un diagnóstico sobre el complejo de electrónica de consumo en la Argentina para el período 2003-2014, observando las características de la dinámica productiva local, así como sus efectos sobre las cuentas públicas y en la balanza comercial. A partir de ello, se pretende dar cuenta de los principales elementos que deben considerarse si se pretende avanzar en la estrategia de sustitución de importaciones de bienes electrónicos, dada la actual configuración de la cadena global de valor.","palabras_clave":"ELECTRÓNICA DE CONSUMO|ARGENTINA|DESARROLLO ECONÓMICO|SUSTITUCIÓN DE IMPORTACIONES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2689,"idioma_id":4,"titulo":"High temperature crystal chemistry of the n = 3 Ruddlesden?Popper phase LaSr3Fe1.5Co1.5O10 &#8722; &#948;","resumen":"The crystal chemistry of the n = 3 Ruddlesden-Popper phase LaSr3Co1.5Fe1.5O10-&#948;  has been studied in the temperature range 20 &#8804; T &#8804; 900 °C by in situ Neutron Powder Diffraction (NPD), and thermogravimetric and linear expansion measurements. The presence of oxygen vacancies at the O(2) and O(4) crystal sites, in the central perovskite layer, along with the variation of the bottleneck space available for oxygen migration with temperature at T > 300 °C indicates the O(4)-O(4) jumps predominate during oxide ion diffusion. Absolute oxygen content measurements support oxygen excess (> 10.0) at temperatures below 300 °C, which is unusual for the n = 3 R-P phases. The total expansion in the temperature range 25 &#8804; T &#8804; 900 °C , alfa =  = 26.5 (1) × 10-6 K-1, is twice the values reported for the electrolytes. The linear expansion along the c-axis, &#61537;c = 34.15 (1) × 10-6 K-1, is mainly absorbed by the perovskite block while the width of the rock salt layers remains nearly constant. Additionally, the  oxygen chemical expansivity (°C) value determined for this layered compound, &#61538;C = 0.670,  was found  to be approximately three times larger than those reported for the three dimensional perovskite system La1-xSrxCoO3-d.","palabras_clave":"RuddlesdenPopper phases|Neutron Powder Diffraction|Mixed conductors|SOFC cathodes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2690,"idioma_id":4,"titulo":"On the physical processes ruling an atmospheric pressure air glow discharge operating at an intermediate current regime","resumen":"Low-frequency (100 Hz), intermediate-current (50 to 200 mA) glow discharges were experimentally investigated in atmospheric pressure air between blunt copper electrodes. Voltage?current characteristics and images of the discharge for different inter-electrode distances are reported. A cathode-fall voltage close to 360 V, independent of the current discharge, and a constant current density at the cathode surface of about 11 A\/cm2 for different discharge currents were found. The visible emissive structure of the discharge resembles to that of a typical low-pressure glow thus suggesting a similar electric field distribution in the discharge. A kinetic model for the ionization processes in the discharge is also presented with the aim of identifying the main physical processes ruling the discharge behavior. The numerical results indicate the presence of a non-equilibrium plasma with rather high gas temperature (above 4000 K) leading to the production of components such as NO, O and N which are usually absent in low-current glows thus causing that the ionization by electron-impact will be replaced with associative ionization which is independent of the reduced electric field. This leads to a negative V-I characteristic curve, in spite of the glow features of the discharge. Besides several estimations show that the discharge seems to be stabilized by heat conduction; being thermally stable due to its reduced size. All the quoted results indicate that this discharge regime may be considered to be close to an arc, but it is still a glow discharge as demonstrated by its overall properties, supported also by thermal non-equilibrium.","palabras_clave":"ELECTRICAL DISCHARGES|HIGH PRESSURE GLOW"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2691,"idioma_id":4,"titulo":"Ecological biodiversity of sandy grassland paddock, with bovine grazing history in central region of San Luis (Abstract)","resumen":"Ecological biodiversity of sandy grassland paddock, with bovine grazing history in central region of San Luis.","palabras_clave":"BIODIVERSITY|SANDY GRASSLAND|GRAZING HISTORY|SAN LUIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2692,"idioma_id":4,"titulo":"Effect of accessibility to drinking water on the behavior of grazing breeding cows (Abstract)","resumen":"Effect of accessibility to drinking water on the behavior of grazing breeding cows.","palabras_clave":"DRINKING-WATER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2693,"idioma_id":4,"titulo":"Development and validation of a CD-MEKC system for the simultaneous determination of dihydrostreptomucin sulfate and two benzylpenicillin salts","resumen":"A CD-MEKC system using sodium dodecyl sulfate and sulfated-b-cyclodextrin to achieve the simultaneous separation of Penicillin G procaine, Penicillin G benzatine and dihydrostreptomycin sulfate in pharmaceutical and veterinary dosage forms was developed. Several parameters were evaluated, including buffer type and concentration, cyclodextrin type and concentration, and organic solvent and instrumental parameters. The optimized system consisted of 50mM SDS, 1% sulfated-ß-cyclodextrin, and 10mM pH 9.0 borate buffer. Capillary temperature was kept at 35°C, and an electrophoretic system was operated under positive polarity at a constant voltage of 18 kV. Validation parameters such as specificity, linearity, LOD, and LOQ, precision, accuracy, and robustness were assayed. Therefore, the developed method was found to be appropriate for quality control of Penicillin G procaine, Penicillin G benzatine, and dihydrostreptomycin sulfate.  A CD-MEKC system using sodium dodecyl sulfate and sulfated-b-cyclodextrin to achieve the simultaneous separation of Penicillin G procaine, Penicillin G benzatine and dihydrostreptomycin sulfate in pharmaceutical and veterinary dosage forms was developed. Several parameters were evaluated, including buffer type and concentration, cyclodextrin type and concentration, and organic solvent and instrumental parameters. The optimized system consisted of 50mM SDS, 1% sulfated-ß-cyclodextrin, and 10mM pH 9.0 borate buffer. Capillary temperature was kept at 35°C, and an electrophoretic system was operated under positive polarity at a constant voltage of 18 kV. Validation parameters such as specificity, linearity, LOD, and LOQ, precision, accuracy, and robustness were assayed. Therefore, the developed method was found to be appropriate for quality control of Penicillin G procaine, Penicillin G benzatine, and dihydrostreptomycin sulfate.","palabras_clave":"CHIRAL MICELLAR CAPILLARY ELECTROPHORESIS|DIHYDROSTREPTOMICYN SULFATE|PENICILLIN G BENZATINE|PENICILLIN G PROCAINE|QUALITY CONTROL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2694,"idioma_id":4,"titulo":"Tetronic® 904-containing polymeric micelles overcome the overexpression of ABCG2 in the blood-brain barrier of rats and boost the penetration of the antiretroviral efavirenz into the central nervous system","resumen":"Safety concerns for fetus development of zidovudine (AZT) administration as prophylaxis of vertical transmission of HIV persist. We evaluated the participation of the ATP-binding cassette efflux transporter ABCG2 in the penetration of AZT into the fetal brain and the relevance for drug safety. Oral daily doses of AZT (60 mg\/kg body weight) or its vehicle were administered between post gestational days 11 (E11) and 20 (E20) to Sprague-Dawley pregnant rats. At E21, animals received an intravenous bolus of 60 mg AZT\/kg body weight in the presence or absence of the ABCG2 inhibitor gefitinib (20 mg\/kg body weight, ip) and AZT in maternal plasma and fetal brain were measured by HPLC-UV and analyzed with the PKsolver software. ABCG2 protein expression in placenta and fetal brain and mitochondrial function and ultrastructure in fetal brain were also analyzed. In utero chronic exposure to AZT markedly induced ABCG2 expression in placenta and fetal brain whereas did not significantly alter mitochondrial functionality in the fetal brain. The area-under-the-concentration-time-curve of AZT significantly decreased in fetal brains isolated from AZT-exposed fetuses compared to control group, but this effect was abolished by ABCG2 inhibition. Our results suggest that the absence of mitochondrial toxicity in the fetal brain after chronic in utero administration of AZT could be attributed to its low accumulation in the tissue caused, at least in part, by ABCG2 overexpression. We propose that any interference with ABCG2 activity due to genetic, pathological or iatrogenic factors would increase the amount of zidovudine reaching the fetal brain and this could increase the risk of toxicity of this drug on the tissue.","palabras_clave":"AIDS|EFAVIRENZ|NANOTECHNOLOGY|CENTRAL NERVOUS SYSTEM|POLYMERIC MICELLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2695,"idioma_id":4,"titulo":"Enhancement of thermoplastic starch final properties by blending with poly(\u0002e-caprolactone)","resumen":"Final properties of two thermoplastic corn starch matrices were improved by adding poly(-caprolactone), PCL, at 2.5, 5, and 10% w\/w. One of the thermoplastic starch matrices was processed usingwater and glycerol as plasticizers (SG) and the other one was plasticized with a mixture of glycerol andsodium alginate (SGA). Blends were suitably processed by melt mixing and further injected. Films obtainedby thermo-compression were flexible and easy to handle. Microstructure studies (SEM and FTIR) revealeda nice distribution of PCL within both matrices and also a good starch?PCL compatibility, attributed to thelower polyester concentration. The crystalline character of PCL was the responsible of the increment inthe degree of crystallinity of starch matrices, determined by XRD. Moreover, it was demonstrated by TGAthat PCL incorporation did not affect the thermal stability of these starch-based materials. In addition, ashift of Tgvalues of both glycerol and starch-rich phases to lower values was determined by DSC and DMAtests, attributed to the PCL plasticizing action. Besides, PCL blocking effect to visible and UV radiationswas evident by the incremented opacity and the UV-barrier capacity of the starch films. Finally, watervapor permeability and water solubility values were reduced by PCL incorporation.","palabras_clave":"Thermoplastic corn-starch|Poly(e\u0002-caprolactone)|Thermal processing|Structural and final propertiesa"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2760,"idioma_id":5,"titulo":"Traducción y validación del Cuestionario sobre Agenciamiento de la Actividad Laboral (CAAL), en sujetos argentinos","resumen":"Traduccion y validación de un cuestionario de actividad laboral en sujetos de argentina","palabras_clave":"Cuestionario|Inventario|Laboral|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2764,"idioma_id":5,"titulo":"Validez y Confiabilidad de la Prueba de Running Memory Span","resumen":"El objetivo de este trabajo fue adaptar y validar el Running Memory Span Task (Broadway & Engle, 2010) o tarea de amplitud rápida de estímulos, la cual es una tarea estándar para evaluar la memoria de trabajo que tiene asociado un componente de inhibición y se encuadra en el modelo de control inhibitorio de la memoria de trabajo de Engle y cols. (Engle, 1996; Kane & Engle, 2000). Para ello, 106 estudiantes universitarios de ambos sexos completaron en una única sesión la prueba de amplitud rápida de estímulos, junto con la tarea de amplitud de lectura, la tarea de amplitud de dígitos directos y la tarea de amplitud de no-palabras. La prueba mostró una buena fiabilidad por consistencia interna de los datos (alfa de Cronbach = .78), los análisis de correlaciones mostraron que la tarea de amplitud rápida de estímulos se asoció significativamente con el resto de tareas de memoria de trabajo, y el resultado del análisis factorial confirmatorio mostró que la tarea evalúa un componente ejecutivo de la memoria de trabajo verbal. Estos resultados indicarían que la prueba de amplitud rápida de estímulos puede ser considerara una prueba apropiada, valida y confiable para evaluar el componente ejecutivo de la memoria de trabajo verbal, asociado a un proceso e inhibición.INDEXACIÓN: Núcleo Básico de Revistas Científicas Argentinas, LATINDEX, REDALYC, PSICODOC, DIALNET, DOAJ, IMBIOMED, e-Revistas.","palabras_clave":"MEMORIA DE TRABAJO|RUNNING MEMORY SPAN|VALIDEZ|CONFIABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2765,"idioma_id":4,"titulo":"Time&#8722;Energy Uncertainty and Electronic Correlation in H+ &#8722;Graphite Collisions","resumen":"The formation of negative ions in the scattering of protons by a highlyoriented pyrolytic graphite (HOPG) surface is theoretically and experimentally analyzedfor a large scattering angle and compared with previous results obtained in the samesystem but for a forward scattering geometry. These experiments were motivated by thefact that the interaction of a hydrogen atom with a surface is the prototype system forstudying the intra-atomic Coulomb repulsion in an s-like valence orbital localized in theatom. We tried to answer the open questions related to the electronic correlation effectsand the influence of the detailed surface band structure by using appropriate theoreticalmodels. The comparison with the experiment of theoretical results obtained by usingdifferent limit approximations of the electronic repulsion in the atomic state shows theexpected validity ranges according to the ion velocity. However, the most remarkableconclusion obtained from this comparison is the nonvalidity of an adiabatic picture of theenergy levels shifted by the interactions with the surface atoms, when the energyuncertainty introduced by the ion velocity becomes of the order of the electronic repulsionin the hydrogen ground state.","palabras_clave":"ELECTRONIC CORRELATION|ION SCATTERING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2767,"idioma_id":4,"titulo":"Determination of the spinel group end-members based on electron microprobe analyses","resumen":"The spinel group minerals have been the focus of many studies, not only because of their economic interest, but also due to the fact that they are very useful as petrogenetic indicators. The application End-Members Generator (EMG) allows to establish, based on electron microprobe analyses (EMPA), the 19 end-members of the spinel group: MgAl2O4 (Spinel sensu stricto, s.s.), FeAl2O4 (Hercynite), MnAl2O4 (Galaxite), ZnAl2O4 (Gahnite), MgFe2O4 (Magnesioferrite), Fe3O4 (Magnetite), MnFe2O4 (Jacobsite), ZnFe2O4 (Franklinite), NiFe2O4 (Trevorite), MgCr2O4 (Magnesiochromite), FeCr2O4 (Chromite), MnCr2O4 (Manganochromite), ZnCr2O4 (Zincochromite), NiCr2O4 (Nichromite), MgV2O4 (Magnesiocoulsonite), FeV2O4 (Coulsonite), MnV2O4 (Vuorelainenite), Mg2TiO4 (Qandilite) and Fe2TiO4 (Ulvöspinel). EMG is an application that does not require an installation process and was created with the purpose of performing calculations to obtain: cation proportions (per formula unit, p.f.u.), endmembers of the spinel group, redistribution proportions for the corresponding end-members in the Magnetite prism or Ulvöspinel prism and a data validation section to check the results. EMG accepts .csv data files and the results obtained can be used to represent a given dataset with the SpinelViz program or any other 2D and\/or 3D graph plotting software.","palabras_clave":"Electron microprobe analyses|Mineral Formula"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2768,"idioma_id":4,"titulo":"Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic or non-pathogenic Junín virus strains","resumen":"The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection                     of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection                     with the C#1 strain (attenuated) and even more susceptible to infection with the P (virulent) JUNV strain. However, hpDC elicited                     different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV                     strains.","palabras_clave":"JUNIN VIRUS|HUMAN PLASMACYTOID DENDRITIC CELLS|hpDC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2769,"idioma_id":5,"titulo":"Identificación de stocks pesqueros de la corvina de río (Plagioscion ternetzi)   de los ríos Paraguay y Paraná, mediante el análisis morfométrico de sus otolitos","resumen":"La identificación de stocks pesqueros es un requisito básico para el manejo y la gestión de la pesca. El objetivo de este trabajo fue describir por primera vez los otolitos de la corvina de río P. ternetzi y evaluar la existencia de diferentes stocks pesqueros entre dos áreas de la Cuenca del Plata, cuenca baja del río Paraguay y el río Paraná medio. Con este fin, cinco índices morfométricos aplicados sobre los otolitos sagittae (rectangularidad, circularidad AO\/LO, SS\/SO y PS\/PO) fueron comparados entre los sitios de estudio. Los otolitos sagittae son semicirculares y presentan bordes lisos. El sulcus acusticus es de tipo heterosulcoide y curvo, con abertura pseudoostio-caudal. Se observaron diferencias significativas para circularidad, rectangu-laridad, SS\/SO y PS\/PO (t- test, P &lt; 0,05). El análisis multiparamétrico T2 de Hotteling mostró diferencias significativas entre los sitios de estudio (P &lt; 0,006) mientras que el análisis canónico discriminante mostró un alto porcentaje de clasificación de los individuos (&gt;69%). Los resultados obtenidos sugieren que las poblaciones de esta especie de los ríos Paraguay","palabras_clave":"Plagioscion ternetzi|morfometría|otolito|stocks pesquero|Río Paraná|Río Paraguay"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2770,"idioma_id":4,"titulo":"Diagnosis of congenital Trypanosoma cruzi infection: a serologic test using Shed Acute Phase Antigen (SAPA) in maternal-child binomial samples","resumen":"Chagas congenital infection is an important health problem in endemic and non-endemic areas in which Trypanosoma cruzi-infected women can transmit the parasite to their offspring. In this study, we evaluated the antibody levels against the T. cruzi Shed Acute Phase Antigen (SAPA) in 91 binomial samples of seropositive pregnant women and their infected and non-infected children by ELISA. In 70 children without congenital T. cruzi transmission, the titers of anti-SAPA antibodies were lower than those of their seropositive mothers. In contrast, 90.5% of 21 congenitally infected children, at around 1 month of age, showed higher anti-SAPA antibody levels than their mothers. Subtracting the SAPA-ELISA mother OD value to the SAPA-ELISA child OD allowed efficient detection of most T. cruzi congenitally infected children immediately after birth, when total anti-parasite antibodies transferred during pregnancy are still present in all children born to seropositive women. A positive correlation was observed between parasitemia levels in mothers and infants evaluated by quantitative DNA amplification and anti-SAPA antibody titers by ELISA. As SAPA serology has proved to be very efficient to detect T. cruzi infection in mother?child binomial samples, it could be of extreme help for early diagnosis of newborns, in maternities and hospitals where DNA amplification is not available. This prompt diagnosis may prevent drop out of the long-term follow-up for future diagnosis and may ensure early trypanocidal treatment, which has proved to be efficient to cure infants with congenital Chagas disease","palabras_clave":"TRYPANOSOMA CRUZI|CONGENITAL iNFECTION|PREGNANT WOMEN |INFANTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2771,"idioma_id":4,"titulo":"Comment on 'Exploring chaos in the Dicke model using ground-state fidelity and the Loschmidt echo'","resumen":"In a recent paper [Phys. Rev. E 90, 022920 (2014)] a study of the ground-state fidelity of the Dicke model as a function of the coupling parameter is presented. Abrupt jumps of the fidelity in the superradiant phase are observed and are assumed to be related to the transition to chaos. We show that this conclusion results from a misinterpretation of the numerics. In fact, if the parity symmetry is taken into account, the unexpected jumps disappear.","palabras_clave":"CAOS CUANTICO|MODELO DE DICKE|LOSCHMIDT ECHO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2772,"idioma_id":4,"titulo":"Development of a very sensitive electrochemical immunosensor for the determination of 17&#61538;-estradiol in bovine serum samples","resumen":"This study describes the development of a very sensitive electrochemical immunosensor (EI) for the determination of 17B-estradiol (17B-E). The novelty of this immunosensor is that the detection of 17B-E is carried out without sample pretreatment and unlabeled neither the antigen nor the antibody. Very good results in terms of sensitivity, kinetics, and working range are obtained. The immunosensor was constructed by immobilization of the anti-17B-E monoclonal antibody (mAbE) on a gold disk electrode modified with gold nanoparticles on a cysteamine self-assembled monolayer (AuNP-cys-Au disk). Bovine serum samples were spiked with known amounts of 17B-E and incubated on mAbE-AuNP-cys-Au disk electrodes. Then, the EI was transferred to pH 5.00 citrate buffer solutions, containing horseradish peroxidase (HRP), pyrocatechol (H2Q), and H2O2 at given concentrations. The 17B-E and H2Q, both enzyme co-substrates, react with HRP. The HRP, which did not react with 17B-E, in the presence of H2O2 catalyzes the oxidation of H2Q to o-benzoquinone (Q). The back electrochemical reduction of Q to H2Q was detected on the modified gold electrode surface by square wave voltammetry. The electrochemical signal was proportional to the amount of H2Q that reacts with the enzyme, and inversely proportional to the amount of 17B-E presents in the bovine serum samples. The EI showed a linear range from 0.54 to 1.36 x 104 pg mL-1.The limit of detection (LOD) was 0.84 pg mL-1. Recovery percentages were very good, with values of 99.7, 106, and 105 % for 10, 50 and 100 pg mL-1, respectively. This EI is an attractive tool for the 17B-E determination in bovine serum samples.","palabras_clave":"IMMUNOSENSOR|ENZYME IMMUNOASSAYS|17-BETA-ESTRADIOL|GOLD NANOPARTICLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2798,"idioma_id":5,"titulo":"Circulación de información y representaciones del trabajo en el servicio doméstico","resumen":"Unade las características del trabajo doméstico remunerado es sudesarrollo en el domicilio privado del empleador. Esta característicaimplica el aislamiento de las trabajadoras durante la mayor parte desu jornada de trabajo, lo que impone grandes obstáculos aldesarrollo de instancias de acción colectiva. Sin embargo, eltrabajo en el servicio doméstico también transcurre en espacios quetrascienden los límites de los domicilios particulares. Si bien aveces se trata de lugares en los que se permanece por poco tiempo(plazas, comercios, espacios comunes de edificios, etc.), constituyenpuntos de encuentro con otras trabajadoras que posibilitan elintercambio de experiencias de trabajo, intercambios en los quecircula información sobre la actividad que resulta de un valorcentral para las mujeres que se desempeñan en este sector. Así, lacirculación de información se insinúa como un componente deimportancia tanto en la configuración de las relaciones de trabajoen las que se insertan las mujeres empleadas en el serviciodoméstico, como en las posibilidades de organización colectiva.Sobre la base de un estudio cualitativo, el objetivo de este artículoes indagar en torno de la manera en que esta información afecta laconfiguración de la relación laboral entre trabajadoras yempleadores\/as y en las condiciones de trabajo de las primeras. Paraello, luego de una breve caracterización de este sector de actividaden la Argentina, nos centraremos en el análisis de los espacios quehabilitan estos intercambios, el tipo de información que allícircula y la especificidad del rol que cumplen las organizacionescolectivas de trabajadoras domésticas. En un segundo momento,abordaremos la manera en que esa información es movilizada por lasempleadas en sus experiencias cotidianas de trabajo.","palabras_clave":"Mujeres |Trabajo doméstico|Representaciones|Información"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2857,"idioma_id":4,"titulo":"The effector protein BPE005 from B. abortus induces collagen deposition and MMP-9 down-modulation via TGF-&#946;1 in hepatic stellate cells","resumen":"The liver is frequently affected in patients with active brucellosis. In the present study, we identified a virulence factor involved in the modulation of hepatic stellate cells function and consequent fibrosis during B. abortus infection. This study assessed the role of BPE005 protein from B. abortus in the fibrotic phenotype induced on hepatic stellate cells during B. abortus infection in vitro and in vivo. We demonstrated that the fibrotic phenotype induced by B. abortus on hepatic stellate cells (LX-2) was dependent on BPE005, a protein associated to the type IV secretion system (T4SS) VirB from B. abortus. Our results indicated that B. abortus through the BPE005-secreted protein inhibits MMP-9 secretion and induces concomitant collagen deposition by LX-2 cells. BPE005 is a small protein containing a cyclic nucleotide monophosphate binding domain (cNMP) that modulates LX-2 cell phenotype through a mechanism that is dependent on cyclic adenosine monophosphate (cAMP)\/ protein kinase A (PKA) signaling pathway. Altogether, these results indicate that B. abortus tilts LX-2 cells to a profibrogenic phenotype employing a functional T4SS and the secreted protein BPE005 through a mechanism that involved cAMP and PKA signaling pathway.","palabras_clave":"BRUCELLA|BPE|TIVSS|LIVER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2858,"idioma_id":5,"titulo":"Variabilidad del régimen fluvial en cuencas de la región de Cuyo, Argentina","resumen":"La detección de cambios a largo plazo en variables hidrológicas, es necesario para determinar el efecto de la variabilidad climática en los sistemas hídricos y es fundamental para la planificación de los recursos hídricos. El objetivo del presente trabajo es detectar cambios en el régimen de escurrimiento a partir del análisis de tendencias de largo plazo y cambios abruptos en cuencas con nacientes en la cordillera de Los Andes y vertiente oriental entre los 31º y 35º S. Se tomaron caudales medios diarios de 23 sitios de aforo y se definieron 19 variables de caudal (anual, extremos, mensuales y estacionales). Se realizó un análisis exploratorio de datos y luego se aplicaron test estadísticos paramétricos y no paramétricos para la detección de tendencias y saltos abruptos con un nivel de significancia del 95%. En el presente estudio el 84% de las series de variables analizadas no cumple con uno o dos de los tres supuestos de normalidad, aleatoriedad e independencia, solo el 16% los cumple. Los datos dudosos encontrados son coincidentes con años de ocurrencia de eventos ENSO. El 73% de las variables analizadas no presentó tendencias significativas. El 26% presentó tendencias positivas y el 1,2% negativas. Las tendencias positivas están principalmente relacionadas con las variables vinculadas a los períodos de estiaje o caudales mínimos. Mientras que las tendencias negativas encontradas se vinculan con los períodos de aguas máximas. El 58% de los saltos detectados resultaron ser positivos mientras que el 9% saltos negativos. Los saltos detectados fueron en su mayoría positivos durante la década del 70. En tanto los saltos detectados en la década del 50 fueron negativos. En la década del 80 y 90, se encontraron tantos saltos positivos como negativos. La presencia de no homogeneidad en las series de caudales pueden ser debidos a múltiples factores, sean estos de origen natural o antrópicos. En el caso se las cuencas estudiadas las mismas poseen una baja intervención humana, por lo que es más probable que los cambios detectados provengan de cambios en las variables climáticas.","palabras_clave":"caudal|tendencias|cambios abrupto|Cuyo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2859,"idioma_id":4,"titulo":"Arsenic toxicity in soybean seedlings and their attenuation mechanisms.","resumen":"Even though vast areas contaminated with arsenic (As) are under soybean (Glycine max) cultivation, littleis known about the growth and intrinsic antioxidant metabolism of soybean in response to As exposure.Thus, an evaluation was carried out of plant growth, root anatomy, antioxidant system and photosyntheticpigment content under arsenate (AsV) and arsenite (AsIII) treatment. Soybean seedling growth wassignificantly affected at 25 mM or higher concentrations of AsV or AsIII, and the toxic effect on root growthwas associated with cell death of root tips. Microscopic analysis of cross-sections of As-treated rootshowed a reduction in the cortex area, dark deposits in cortex cells and broken cells in the outer layer.Similarly, in the vascular cylinder, dark deposits within xylem vessel elements and phloem cell wallswere observed. In all the analyzed parameters, the deleterious effect was more evident under AsIII thanAsV treatment. Arsenic-treated soybean seedlings showed increased activity of antioxidant enzymes[total peroxidases (Px) and superoxide dismutase (SOD)] in root and shoot harvested after 2 and 5 d oftreatment. However, a reduction in chlorophyll content and an increase in membrane lipids peroxidationwere observed. It is suggested that root structural alterations induced by As, such as the particularpattern of dark depositions in the vascular system, could be associated with an adaptation or detoxificationmechanism to prevent As translocation to the aboveground tissues.","palabras_clave":"ARSENIC|TOLERANCE|OXIDATIVE STRESS|ROOT ANATOMY|GLYCINEMAX"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2861,"idioma_id":5,"titulo":"El nivel educativo y socioeconómico del hogar y habilidades prelectoras en escuelas urbanas y urbano-marginales de la provincia de Mendoza-Argentina","resumen":"En Argentina, las dificultades en la adquisición de la lectura se originan en diferencias lingüísticas asociadas al nivel sociocultural donde se desarrollan los niños.  El objetivo de este artículo es analizar, en escolares de 4 y 5 años, la relación entre el nivel educativo y socioeconómico del hogar con habilidades lingüísticas precursoras de la lectura.  Esta es una investigación de carácter cuantitativo y de profundidad comparativa. Se evaluaron 120 niños y niñas de salas de 4 y 5 años de Jardín de Infantes de escuelas urbanas (n= 60) y urbano-marginales (n= 60). El nivel socioeconómico del hogar y educativo de los padres se calculó a partir de datos de los registros escolares. En los niños y niñas se evaluó el nivel de vocabulario, conocimiento del nombre y sonido de la letra y conciencia fonológica. Se observó un efecto significativo de la zona sobre el nivel educativo de los padres y el socioeconómico. Se obtuvieron correlaciones positivas del nivel socioeconómico y educativo con el conocimiento del nombre y sonido de la letra. Ambas variables contextuales explicaron parte de la varianza en el conocimiento del nombre y sonido de las letras en niños y niñas de 4 años únicamente: 6% y 13% respectivamente. Los resultados sugieren que las variables contextuales influyen en el conocimiento alfabético pre-escolar que presentan los niños y las niñas y que la intervención pedagógica recibida en la escuela promueve el desarrollo de habilidades lingüísticas. Frente a contextos socioeconómicos heterogéneos, la educación escolar es una variable protectora que regula las desigualdades de orden social promoviendo el desarrollo de habilidades lingüísticas precursoras de la lectura al inicio de la escolaridad.","palabras_clave":"NIVEL SOCIOECONÓMICO FAMILIAR|NIVEL EDUCATIVO|HABILIDADES LINGÜÍSTICAS|HABILIDADES PRELECTORAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2863,"idioma_id":5,"titulo":"Los programas académicos de psicología de la Universidad de Buenos Aires (1896 y 1957): Fundamentos de su investigación y alcances de sus resultados","resumen":"Elartículo muestra los fundamentos teóricos y los alcances previstos de unainvestigación recientemente aprobada titulada ?Los Programas académicos dePsicología de la Universidad de Buenos Aires entre 1896 y 1957: Paisajescontextuales, tensiones discursivas e indicios de profesionalización?. Elproyecto se propone relevar exhaustivamente los programas académicos dePsicología de la Universidad de Buenos Aires, entre 1896 y 1957,sistematizarlos y analizarlos a partir de su contextualización académica,institucional, social y política. Se espera que el entramado discursivo permitareconstruir los diversos momentos institucionales y abordar la constitucióndisciplinar de la psicología en nuestra Universidad. El resultado de lainvestigación prevé la transferencia de sus resultados a partir de laconfección de un catálogo digital disponible en la página web (con el acervo documental y su sistematización) de la Facultad de Psicología,de acceso libre.","palabras_clave":"Historia|Psicologia|Argentina|Programas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2865,"idioma_id":6,"titulo":"Une archéologie socialement utile. Le Musée intégral de la Réserve de biosphère de Laguna Blanca (Argentine).","resumen":"Aire de 7100 km2, la réserve de biosphère de Laguna Blanca en Argentine a été créée en 1982 pour protéger l?écosystème de Laguna Blanca. Mais cette zone comprend aussi de nombreux sites archéologiques. Le Musée intégral de la Réserve de cette biosphère s?est donné pour but non seulement de préserver la faune et la flore mais également le patrimoine historique et le savoir-faire régional. Une expérience hors-norme à vivre au c?ur des cimes andines!","palabras_clave":"réserve de biosphère|Musée intégral|Archéologia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2866,"idioma_id":4,"titulo":"-\tSystemic foot-and-mouth disease vaccination in cattle promotes specific antibody secreting cells at the respiratory tract and triggers local anamnestic-compatible responses upon aerosol infection","resumen":"Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting biungulate species. Commercial vaccines, formulated with inactivated FMD virus (FMDV), are regularly used worldwide to control the disease. Here, we studied the generation of antibody responses in local lymphoid tissues along the respiratory system in vaccinated and further aerosol-infected cattle. Animals immunized with a high-payload monovalent FMD vaccine developed high titers of neutralizing antibodies at 7 days postvaccination (dpv), reaching a plateau at 29 dpv. FMDV-specific antibody-secreting cells (ASC), predominantly IgM, were evident at 7 dpv in the prescapular lymph node (LN) draining the vaccination site and in distal LN draining the respiratory mucosa, although in lower numbers. At 29 dpv, a significant switch to IgG1 was clear in prescapular LN, while FMDV-specific ASC were detected in all lymphoid tissues draining the respiratory tract, mostly as IgM-secreting cells. None of the animals (n = 10) exhibited FMD symptoms after oronasal challenge at 30 dpv. Three days postinfection, a large increase in ASC numbers and rapid isotype switches to IgG1 were observed, particularly in LN-draining virus replication sites already described. These results indicate for the first time that systemic FMD vaccination in cattle effectively promotes the presence of anti-FMDV ASC in lymphoid tissues associated with the respiratory system. Oronasal infection triggered an immune reaction compatible with a local anamnestic response upon contact with the replicating FMDV, suggesting that FMD vaccination induces the circulation of virusspecific B lymphocytes, including memory B cells that differentiate into ASC soon after contact with the infective virus.","palabras_clave":"FMDV|Vaccination"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2868,"idioma_id":4,"titulo":"An Intron 9 CYP19 Gene Variant (IVS9+5G>A), Present in an Aromatase Deficient Girl, Affects Normal Splicing, and It Is Also Present in Normal Human Steroidogenic Tissues","resumen":"ABSTRACT Background\/Aims: Splicing CYP19 gene variants causing aromatase deficiency in 46,XX DSD patients have been reported in few cases. Misbalance between normal and aberrant splicing variants was proposed to explain spontaneous pubertal breast development but incomplete sex maturation progress. The aim of this study is to functional characterize a novel CYP19A1 intronic homozygote mutation (IVS9+5G>A) in a 46,XXDSD girl presenting spontaneous breast development and primary amenorrhea, and to evaluate similar splicing variant expression in normal steroidogenic tissues.Methods: Genomic DNA analysis, splicing prediction programs, splicing assays, in vitro protein expression and enzyme activity were carried out. CYP19A1 mRNA expression in human steroidogenic tissues was also studied. Results:  A novel IVS9+5G>A homozygote mutation was found. In silico analysis predicts the disappearance of the splicing donor site in intron 9, confirmed by patient PBL cP450arom and in vitro studies. Protein analysis showed a shorter and inactive protein.  The intron 9 transcript variant was also found in human steroidogenic tissues. Conclusions: The mutation IVS9+5G>A generates a splicing variant that includes intron 9 which is also present in normal human steroidogenic tissues, suggesting that a misbalance between normal and aberrant splicing variants might occur in target tissues, explaining the clinical phenotype in the affected patient.  Established FactsAromatase, the enzyme complex that catalyzes the synthesis of estrogens from androgens, undergoes different alternative splicing events in the coding region that may lead to both active or inactive proteins in normal and\/or in aromatase deficiency tissues. Novel Insights A novel IVS9+5G>A mutation generating a splicing variant that includes intron 9 was found. This was also present in the absence of the mutation in normal steroidogenesis tissues, suggesting that a misbalance between normal and aberrant splicing variants might explain the partial deficiency phenotype.","palabras_clave":"Aromatase |Steroidogenic|IVS9+5G>A"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2872,"idioma_id":5,"titulo":"Comentario a la resolución 60\/2015 (SEDRONAR)","resumen":"La resolución en comentario  representa un  paso más hacia la consolidación y el fortalecimiento del denominado ?modelo  social? que concibe a la persona que padece un consumo problemático como un ?sujeto  de derecho?.    &nbsp;    La resolución recepta, así, la  exhortación de nuestro máximo tribunal en las causas ?Tufano, Ricardo Alberto  s\/ Internación? de 2005; ?R.M.J. s\/ Insanía?, de 2009 y ?Arriola, Sebastián y  otros s\/ causa n° 9080?, también de 2009, consistente en generar políticas  públicas de salud preventivas y educación, enfocadas  en los grupos más vulnerables, especialmente los menores.     Indudablemente creemos que su punto de partida  es la filosofía basada en el  Progetto Uomo (o Proyecto Hombre), creado  en Italia en 1979 por el sacerdote  Mario Picchi, consistente en promover el proyecto  de vida de cada persona de manera autónoma y sin ningún tipo de dependencia.","palabras_clave":"Sedronar|Persona con consumos problemáticos|Filosofía Proyecto Hombre|Sujeto de derecho"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2947,"idioma_id":4,"titulo":"Phylogeny, species delimitation and convergence in the South American bothriurid scorpion genus Brachistosternus Pocock 1893: Integrating morphology, nuclear and mitochondrial DNA","resumen":"A phylogenetic analysis of the scorpion genus Brachistosternus Pocock, 1893 (Bothriuridae Simon, 1880) is presented, based on a dataset including 41 of the 43 described species and five outgroups, 116 morphological characters and more than 4150 base-pairs of DNA sequence from the nuclear 18S rDNA and 28S rDNA gene loci, and the mitochondrial 12S rDNA, 16S rDNA, and Cytochrome c Oxidase Subunit I gene loci. Analyses conducted using parsimony, Maximum Likelihood and Bayesian Inference were largely congruent with high support for most clades. The results confirmed the monophyly of Brachistosternus, the nominal subgenus, and subgenus Ministernus Francke, 1985, as in previous analyses based only on morphology, but differed in several other respects. Species from the plains of the Atacama Desert diverged basally whereas the high altitude Andean species radiated from a more derived ancestor, presumably as a consequence of Andean uplift and associated changes in climate. Species limits were assessed among species that contain intraspecific variation (e.g., different morphs), are difficult to separate morphologically, and\/or exhibit widespread or disjunct distributions. The extent of convergence in morphological adaptation to life on sandy substrata (psammophily) and the complexity of the male genitalia, or hemispermatophores, was investigated. Psammophily evolved on at least four independent occasions. The lobe regions of the hemispermatophore increased in complexity on three independent occasions, and decreased in complexity on another three independent occasions.","palabras_clave":"Scorpiones|Systematics|Brachistosternus|Phylogeny"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2948,"idioma_id":4,"titulo":"Scanning electron microscopy combined with image processing technique: Microstructure and texture analysis of legumes and vegetables for instant meal.","resumen":"Development and innovation of new technologies are necessary especially in food quality; due that most instrumental technique for measuring quality properties involves a considerable amount of manual work. Image analysis is a technique that allows to provide objective evaluations from digitalized images that can estimate quality parameters for consumer?s acceptance.  The aim of the present research was to study the effect of freeze drying on the microstructure and texture of legume and vegetables using scanning electron microscopy at different magnifications? combined with image analysis. Cooked and cooked freeze dried rehydrated legumes and vegetables were analyzed individually by scanning electron microscopy at different magnifications? (250, 500 and 1000x).Texture properties were analyzed by texture analyzer and image analysis. Significant differences (P<0.05) were obtained for image and instrumental texture parameters. A linear trend with a linear correlation was applied for instrumental and image features. Results showed that image features calculated from Grey level co-occurrence matrix at 1000x had high correlations with instrumental features. In rice, homogeneity and contrast can be applied to evaluate texture parameters gumminess and adhesiviness; Lentils: contrast, correlation, energy, homogeneity and entropy for hardness, adhesiviness, gumminess and chewiness; Potato and carrots: contrast, energy, homogeneity and entropy for adhesiviness, chewiness, hardness, cohesiviness and resilence. Results revealed that combing scanning electron microscopy with image analysis can be a useful tool to analyze quality parameters in legumes and vegetables.","palabras_clave":"GLCM|Freeze drying|quality"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2950,"idioma_id":4,"titulo":"Synthetic DAF-12 modulators with potential use in controlling the nematode life cycle","resumen":"Dafachronic acids (DAs) are 3-keto cholestenoic acids bearing a carboxylic acid moiety at the end of the steroid side chain. These compounds interact with the DAF-12 receptor, a ligand-dependent transcription factor that acts as a molecular switch mediating the choice between arrest at diapause or progression to reproductive development and adult lifespan in different nematodes. Recently, we reported that the 27-nor-&#916;4-DA was able to directly activate DAF-12 in a transactivation cell-based luciferase assay and rescued the Mig phenotype of daf-9(rh50) Caenorhabditis elegans mutants. In the present paper, to investigate further the relationship between the structure of the steroid side chain and DAF-12 activity, we evaluated the in vitro and in vivo activity of &#916;4-DA analogues with modified side chains using transactivation cell-based assays and daf-9(dh6) C. elegans mutants. Our results revealed that introduction of a 24,25-double bond on the cholestenoic acid side chain did not affect DAF-12 activity, whereas shortening the side chain lowered the activity. Most interestingly, the C24 alcohol 24-hydroxy-4-cholen-3-one (6) was an antagonist of the DAF-12 receptor both in vitro and in vivo.","palabras_clave":"Caenorhabditis elegans|daf-9 mutant|DAF-12 receptor|dafachronic acid|molecular dynamics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2953,"idioma_id":4,"titulo":"VIBRATIONAL SPECTRA OF THE TWO HIDRATES OF STRONTIUM OXALATE","resumen":"The infrared and Raman spectra of the two hydrates of strontium oxalate, SrC2O4.H2O and SrC2O4.2H2O, were recorded and discussed on the basis of their structural peculiarities and in comparison with the spectra of the related calcium oxalates and other previously investigated metallic oxalates.","palabras_clave":"Strontium oxalates|Infrared spectra|Raman spectra"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2954,"idioma_id":4,"titulo":"Development and validation of a high performance liquid chromatography method for oligodeoxynucleotides determination in a novel liquid crystal-based formulation","resumen":"The therapeutic benefit of phosphorothioate oligodeoxynucleotides (PS-ODN) containing immune stim- 24  ulatory sequences has been demonstrated in animal models of cancer and infection. Several tools are 25  available for the determination of these oligonucleotides in biological samples and pharmaceutical pre- 26  parations, including UV spectroscopy, dye binding, isotopic tracing, capillary gel electrophoresis (CGE), 27  hybridization-based enzyme-linked immunosorbent assay (ELISA), and chromatography techniques. 28  However, due to inter-assay variability and accuracy problems associated with the afore mentioned 29  methods, we have developed and validated an isocratic high performance liquid chromatographic 30  (HPLC) for analytical determination of PS-ODN containing unmethylated CpG motifs (CpG-ODN). 31  Validation under Food and Drug Administration (FDA) guidelines of the analytical parameters include: 32  linearity (r2 0.9996), LODs (0.86 lg\/ml) and LOQ (6.25 lg\/ml), infra (0.19?3.37%) and inter-day precision 33  (0.63?3.75%) expressed as relative standard deviation (RSD), and robustness parameters (less than 34  2.80%). Using this method, recoveries ranging from 89.93% to 99.90% were obtained. Thus, this method 35  provides a simple, sensitive, precise and reproducible examination which can be readily adapted for 36  the assessment of CpG-ODN in different pharmaceutical preparations","palabras_clave":"ASCORBYL PALMITATE LIQUID CRYSTALS|LIQUID CHROMATOGRAPHY|NUCLEASE STABILITY|OLIGONUCLEOTIDES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2955,"idioma_id":4,"titulo":"Growth hormone, luteinizing hormone and follicle stimulating hormone regulation by neuropeptide Y in both genders of the cichlid fish Cichlasoma dimerus","resumen":"Neuropeptide Y (NPY) is considered the  most potent orexigenic peptide, increasing before  meal time and during fasting. In teleost, most studies  on NPY action upon growth hormone (GH) and  luteinizing hormone (LH) were conducted in females  or group of animals without sex discrimination. The  aim of this study was to evaluate whether NPY  modulates the expression and release of GH and  gonadotropins in both sexes of Cichlasoma dimerus.  By double-label immunofluorescence, we first determined  the association between NPY fibers and pituitary  cells. In addition, we performed in vitro studies to  evaluate the effect of NPY on GH and gonadotropins  expression by real-time PCR, and release by Western  blot, in males and females separately. Contacts  between NPY fibers and GH and follicle-stimulating  hormone (FSH)-producing cells were detected, indicating  possible functional relationships. We observed  an increase in GH release in the culture medium at  2 nM for males (p = 0.043) and 20 nM for females (p = 0.028). Pituitary FSH release was stimulated at  20 nM (p = 0.026) and 200 nM (p = 0.033) for males  and females, respectively. Finally, NPY only increased  b-LH mRNA expression at 20 nM in females  (p = 0.028) and its release at 2 nM (p = 0.049) and  200 nM for males (p = 0.005) and 200 nM for  females (p = 0.018). In conclusion, NPY acts as a  GH-, LH- and FSH-releasing factor, in a dose- and  sex-dependent way.","palabras_clave":"NPY|GH|FSH|LH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2958,"idioma_id":4,"titulo":"Photodynamic inactivation induced by carboxypterin: a novel non-toxic bactericidal strategy against planktonic cells and biofilms of Staphylococcus aureus","resumen":"Microbial related contamination is of major concern and can cause substantial economic losses. Photodynamic inactivation(PDI) has emerged as a suitable approach to inhibit microorganism proliferation. In this work, PDI induced by6-carboxypterin (Cap), a biocompatible photosensitizer (PS), was analyzed. The growth inhibition of Staphylococcusaureus exposed to artificial UV-A radiation and sunlight in the presence of Cap was investigated. After UV-A irradiation,50 &#956;M Cap was able to decrease by three orders (with respect to the initial value) the number of S. aureus cells in earlybiofilms. However, this concentration was 500 times higher than that needed for eradicating planktonic cells. Importantly,under solar exposure, 100 &#956;M Cap was able to suppress sessile bacterial growth. Thus, this strategy is able toexert a bactericidal effect on sessile bacteria and to eradicate planktonic cells by exposing the Cap-containing sample tosunlight.","palabras_clave":"PHOTODYNAMIC|CARBOXYPTERIN|BIOFILM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2959,"idioma_id":4,"titulo":"Pedunculopontine arousal system physiology- implications for schizophrenia","resumen":"This review describes the wake\/sleep symptoms present in Parkinsons disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinsons disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders.","palabras_clave":"PEDUNCULOPONTINE|INSOMNIA|CALCIUM CHANNELS|GAMMA OSCILLATIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2960,"idioma_id":4,"titulo":"Effect of the symmetric cell preparation temperature on the activity of Ba0.5Sr0.5Fe0.8Cu0.2O3-&#948; as cathode for intermediate temperature Solid Oxide Fuel Cells","resumen":"In this work we studied the electrochemical performance of Ba0.5Sr0.5Fe0.8Cu0.2O3-d (BSFCu) as cathodefor Intermediate Temperature Solid Oxide Fuel Cells (IT-SOFC) with Ce0.9Gd0.1O1.95 (CGO) electrolyte andthe effect of the symmetric cell preparation temperature on the oxygen reduction reaction (ORR) activity.Symmetrical cells with the configuration BSFCu\/CGO\/BSFCu were prepared at 900 C, 950 C and 1000 Cto perform the electrochemical characterization in the 500e700 C temperature range. The resultant areaspecific resistance (ASR) of the cells with different preparation temperatures followed the tendency:ASR900C < ASR950C < ASR1000C. The symmetric cell constructed at 900 C showed ASR values of 0.18,0.078 and 0.035 U cm2 at 600, 650 and 700 C respectively, which demonstrated superior electrochemicalactivities than previous reports. Additional, X-ray diffraction (XRD), scanning and transmissionelectron microscopies (SEM and TEM) techniques were used to characterize the microstructure of theoriginal and fired BSFCu materials and correlate it with the cell preparation temperature.","palabras_clave":"IT-SOFC|Cathode|Gel combustion|XRD|EIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2961,"idioma_id":4,"titulo":"Characterizing paths graphs on bounded degree trees by minimal forbidden induced subgraphs","resumen":"An undirected graph $G$ is called a VPT graph if it is the vertex intersection graph of a family of paths in a tree. The class of graphs which admit a VPT  representation in a host tree with maximum degree at most $h$ is denoted by $[h,2,1]$. The classes $[h,2,1]$ are closed under taking induced subgraphs,  therefore each one can be characterized by a family of minimal forbidden induced subgraphs. In this paper we associate the minimal forbidden induced  subgraphs for $[h,2,1]$ which are VPT with (color) $h$-critical graphs. We describe how to obtain minimal forbidden induced subgraphs from critical graphs,  even more, we show that the family of graphs obtained using our procedure is exactly the family of VPT minimal forbidden induced subgraphs for $[h,2,1]$.  The members of this family together with the minimal forbidden induced subgraphs for VPT cite{B9,B11}, are the minimal forbidden induced subgraphs for  $[h,2,1]$, with $hgeq 3$. By taking $h=3$ we obtain a characterization by minimal forbidden induced subgraphs of the class VPT $cap$ EPT=EPT $cap$  Chordal$=[3,2,2]=[3,2,1]$ (see cite{B4}).","palabras_clave":"graph theory|intersection graphs"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2962,"idioma_id":5,"titulo":"Orientación de los empresarios de Córdoba-Argentina hacia la sustentabilidad y la Responsabilidad Social Empresaria: Identificación de sus variables asociadas a cada constructo","resumen":"El problema de investigación que se plantea para este artículo se encuentra en discernir si los empresariosobjeto de estudio se orientan hacia la sustentabilidad o hacia la responsabilidad social empresaria, en funciónde su consideración acerca de determinadas variables económicas, sociales y ambientales. Para ello, se proponen3 objetivos: 1) identificar variables relacionadas con los aspectos económicos, sociales y ambientalesque permiten catalogar a una empresa como responsable, en el contexto de estudio, 2) relacionar dichas variablescon los constructos de sustentabilidad o responsabilidad social empresarial y 3) determinar hacia quéconstructo se orientan los empresarios que conforman el objeto de estudio. El estudio empírico se desarrollócon empresarios de 127 organizaciones de la Provincia de Córdoba-Argentina y concluye que la hipótesisinicial no es válida, dado que las variables más importantes senaladas ? por los encuestados responden, casien su totalidad, al constructo de sustentabilidad y no al de responsabilidad social empresarial.","palabras_clave":"ANÁLISIS EMPÍRICO|CÓRDOBA|PERCEPCIÓN|SUSTENTABILIDAD ORGANIZACIONAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":2970,"idioma_id":4,"titulo":"Microbial pelagic metabolism and CDOM characterization in a phytoplankton-dominated versus a macrophyte-dominated shallow lake","resumen":"Dominant primary producer in macrophyte- or phytoplankton-dominated shallow lakes might imply differences in dissolved organic carbon (DOC) composition. We compared chromophoric dissolved organic matter (CDOM), plankton respiration (R), and bacterial (BP) and primary production (PP), in two contrasting shallow lakes. We hypothesized that DOC from the macrophyte-dominated lake would be qualitatively inferior, so that it can support a lower yield than DOC from the phytoplankton- dominated one. Macrophyte-dominated lake had more humic and aromatic CDOM, though molecular weight was similar in both lakes. A clear synchronism between lakes was observed in mean depth and several CDOM absorption coefficients, suggesting an external driver of the variation in DOC concentration and CDOM quality. The positive BPPP and BP-Chl-a correlations in the macrophytedominated lake point out to a dependence of bacteria on phytoplankton for a supply of labile DOC. In turn, BP in the phytoplankton-dominated lake was balanced with grazing by HF (heterotrophic flagellates). The significantly higher HB:DOC and HF:DOC carbon ratios in the phytoplankton-dominated lake also suggest that better DOC quality would mean relatively more efficient C transfer to higher trophic levels. According to PP:BP and PP:R ratios both lakes should be considered autotrophic, although the macrophyte-dominated lake would be comparatively more heterotrophic.","palabras_clave":"alternative state|macrophytes|bacterial production"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3039,"idioma_id":4,"titulo":"Translating Niche Features: Modeling Differential Exposure of Argentine Reptiles to Global Climate Change","resumen":"Global Climate Change (GCC) affects the distributions of ectotherms and may be the cause of several conservation problems, such as great displacement of climatic suitable spaces for species and, consequently, important reductions of the extent of livable places, threatening the existence of many of them. Species exposure (and hence vulnerability) to GCC is linked to features of their climatic niches (such as the relative position of the inhabited localities of each species in the climatic space), and therefore to characteristics of their geographic ranges (such as the extent of the distributions or altitudinal range inhabited by the species). In order to analyze the pattern of response of Argentine reptiles to GCC, we ran Phylogenetic Generalized Least Squares Models using species exposure to GCC as a response variable, and (a) niche properties (breadth and position of the species in the climate space), and (b) general features of the distribution of species (maximum latitude, altitudinal range, maximum elevation, distributional range and proximity to the most important dispersal barrier), as predictors. Our results suggest that the best way to explain GCC exposure is by combining breadth and position of climatic niche of the species or combining geographic features indicators of both niche characteristics. Our best model shows that, in our study area, species with the narrowest distributional ranges that also inhabit the highest elevations are the most exposed to the effects of GCC. In this sense, reptile species from Yungas, Puna and Andes ecorregions could be especially vulnerable to the effects of GCC. We believe that these types of models may represent an interesting tool for determining species and places particularly threatened by the effects of GCC, and which should be strongly considered in conservation planning","palabras_clave":"Climate Change exposure; |Species Distribution; |Phylogenetic Generalized Least Square Models;| Reptiles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3040,"idioma_id":4,"titulo":"Effect of different freeze drying cycle in Semimembranous and Gluteus Medius bovine muscles: changes on microstructure, senescence, texture and physicochemical parameters","resumen":"The aim of the present research was to evaluate effects of freezing drying cycle in Semimembranous and Gluteus Medius bovine muscles (sp: Aberdeen Angus) for instant meal. Samples were analyzed by Scanning electron microscopy; texture and senescence parameters were analyzed by image analysis and physicochemical properties by instrumental assays. Micrographs revealed that a higher porous size structure and shrinkage of muscle fiber diameter was obtained at -40°C. Significant differences (P<0.0001) were obtained for physicochemical, senescence and texture parameters. Freeze drying at -50°C and -60 °C revealed that lightness (L*) and yellowness (b*) increased and redness (a*) decreased; water absorbing capability decreased and texture parameters changed.  In Semimembranous and Gluteus Medius bovine muscles senescence, texture and physicochemical parameters reflected significant changes when freeze drying cycle was applied at ?50 and -60 °C than &#8722;40 °C.","palabras_clave":"freeze drying|image analysis|muscle tissue|quality"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3041,"idioma_id":4,"titulo":"Effects of glycerol and sugar mixing temperature on the morphologic and functional integrity of cryopreserved ram sperm","resumen":"Sperm deep freezing procedures for ram semen have considerable variations regarding the steps being employed for cooling, freezing, and addition of cryoprotectants. In this work, we evaluated the effects of the addition of glycerol and\/or the disaccharides sucrose and trehalose to hypertonic diluents either before or after cooling from 30°C to 5°C in Merino Australian ram semen cryopreservation. Using optical and transmission electron microscopy techniques, we assessed that glycerol was beneficial to the cooling process independently of its addition at 30°C or 5°C in terms of sperm membrane integrity in different regions of the plasma membrane (acrosomal region, 14.5% higher integrity; postacrosomal region, 8.0% higher integrity [P<0.01]; hypoosmotic swelling test [HOST], 10.8% higher integrity [P<0.001]). Disaccharides were necessary for a better cryopreservation in liquid nitrogen, and the best procedure was their addition after cooling at 5°C (12% higher sperm motility [P<0.001]; 8% higher acrosome integrity, [P<0.05]; 9.5% higher plasma membrane integrity assessed by HOST [P<0.001]). Trehalose showed a greater preservation cryoprotectant capacity than sucrose, as indicated by sperm motility after thawing (8.1% greater [P<0.01]) and by the integrity of the intermediate piece (20% greater [P<0.05]). From these results, we conclude that the best procedure for ram semen cryopreservation in hypertonic disaccharide-containing diluents is the addition of glycerol and trehalose after the cooling process, at 5°C.","palabras_clave":"TREHALOSE|COOLING PROCESS|PLASMA MEMBRANE|FROZEN-THAWED RAM SPERMATOZOA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3042,"idioma_id":4,"titulo":"Physicochemical Characterization of 2&#8209;Hydroxybenzophenone with &#946;&#8209;Cyclodextrin in Solution and Solid State","resumen":"The characterization of the inclusion complex between 2-hydroxybenzophenone (2OHBP) and &#946;-cyclodextrin (&#946;CD) in the solid state was performed using Fourier-Transform infrared spectroscopy (FTIR), Powder X-ray diffractometry (PXRD), Differential scanning calorimetry (DSC), Thermogravimetric analysis (TGA) and Transmission electron microscopy (TEM). The apparent formation constant of the complex was determined by phase solubility diagrams and liquid chromatography (HPLC) at different temperatures. The formation of the inclusion complex induced slight shifts in the FTIR spectrum while by PXRD a new crystalline phase was  observed. TEM studies revealed that the complex forms aggregates of nanometric size. The inclusion complex showed a higher solubility in the tested dissolution media than free 2OHBP.  Moreover, the freeze dried solid complex exhibits a higher thermal stability than the solid free drug. The thermodynamic analysis allowed us to conclude that the encapsulation process is endothermic in water and exothermic in methanol-water.","palabras_clave":"hydroxybenzophenone|beta-cyclodextrin|Inclusion complex|TEM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3043,"idioma_id":4,"titulo":"Prey C:P ratio and phosphorus recycling by a planktivorous fish: Advantages in fish selection towards pelagic cladocerans","resumen":"      Prey selection by  the small planktivore Galaxias  maculatus and phosphorus gain  depending on diet has been examined related to predator?prey daily distribution. Prey elemental  composition (C:P ratio) was analysed as a factor of selectivity. Field  experiments were carried out to evaluate the effect of prey on phosphorus  recycling. Results revealed that the pelagic cladoceran Ceriodaphnia dubia was a highly selected prey by all fish  sizes at dawn and dusk, despite its low abundances in comparison with other zooplankters,  while the littoral were ingested only during day. The high selectivity for C. dubia showed that G. maculatus moved to pelagic  zone during night to consume this prey but returned to littoral areas during  day due to the increase in predation risk. Analysis of elemental composition  revealed that P content of C. dubia was significantly higher than other planktonic or  littoral prey (Bosmina longirostris, Boeckella gracilipes and chironomids).  Phosphorus recycling experiments showed that G. maculatus would transport and  supply P in available forms for primary producers. Fish size was observed to influence  P recycling as YOY had significant higher mass-specific P release in the  morning and mid-day when they preyed mainly upon C. dubia. Low prey C:P ratio  appears as a factor that would add benefits to the classical visual fish  selection towards cladocerans, as this preference would imply a net phosphorus  gain for fish.  ","palabras_clave":"zooplankton|elemental ratio|fish predation|litoral - pelagic"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3044,"idioma_id":4,"titulo":"In vitro and in vivo screening of native lactic acid bacteria towards their selection as a probiotic in broiler chickens","resumen":"Among 360 isolates from the gastrointestinal tract (GIT) of broilers, eleven isolates which showed in vitro probiotic properties were identified and selected for further tests. After the in vitro screening, three strains were chosen for the in vivo study of persistence of fresh cultures and then one strain was selected for the in vivo study of persistence of lyophilized culture. Lyophilized Lactobacillus salivarius DSPV 001P was capable of persisting in broilers during a complete rearing, even 28. days following cessation of administration. L. salivarius DSPV 001P administered to broilers and recovered from GIT was compared by pulsed-field gel electrophoresis (PFGE) to ensure that the same genotype was persistently identified. A combination of in vitro and in vivo screening of native lactic acid bacteria (LAB) described in this study may offer a method for selecting the most suitable strain for potential application as a broiler probiotic supplement","palabras_clave":"BROILER|INTESTINAL MICROBIOTA|PROBIOTIC|LACTIC ACID BACTERIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3045,"idioma_id":4,"titulo":"Histamine reduces Boron Neutron Capture Therapy (BNCT)-induced mucositis in an oral precancer model","resumen":"OBJECTIVES:  Searching for more effective and selective therapies for head and neck cancer, we demonstrated the therapeutic effect of boron neutron capture therapy (BNCT) to treat oral cancer and inhibit long-term tumor development from field-cancerized tissue in the hamster cheek pouch model. However, BNCT-induced mucositis in field-cancerized tissue was dose limiting. In a clinical scenario, oral mucositis affects patients´ treatment and quality of life. Our aim was to evaluate different radioprotectors, seeking to reduce the incidence of BNCT-induced severe mucositis in field-cancerized tissue.  MATERIALS AND METHODS:  Cancerized pouches treated with BNCT mediated by boronophenylalanine at 5 Gy were treated as follows: control: saline solution; Hishigh : histamine 5 mg kg-1 ; Hislow : histamine 1 mg kg-1 ; and JNJ7777120: 10 mg kg-1 .  RESULTS:  Hislow reduced the incidence of severe mucositis in field-cancerized tissue to 17% vs CONTROL: 55%; Hishigh : 67%; JNJ7777120: 57%. Hislow was non-toxic and did not compromise the long-term therapeutic effect of BNCT or alter gross boron concentration.  CONCLUSION:  Histamine reduces BNCT-induced mucositis in experimental oral precancer without jeopardizing therapeutic efficacy. The fact that both histamine and boronophenylalanine are approved for use in humans bridges the gap between experimental work and potential clinical application to reduce BNCT-induced radiotoxicity in patients with head and neck cancer.","palabras_clave":"BNCT|ORAL CANCER|HAMSTER CHEEK PUOCH PRECANCER MODEL|MUCOSITIS|RADIOPROTECTOR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3046,"idioma_id":4,"titulo":"An X-ray characterization of the central region of the supernova remnant G332.5-5.6","resumen":"Aims: We present an X-ray analysis of the central region of supernova remnant (SNR) G332.5-5.6 through an exhaustive analysis of XMM-Netwon observations with complementary infrared observations. We characterize and discuss the origin of the observed X-ray morphology, which presents a peculiar plane edge over the west side of the central region. Methods: The morphology and spectral properties of the X-ray SNR were studied using a single full frame XMM-Newton observation in the 0.3 to 10.0 keV energy band. Archival infrared WISE observations at 8, 12 and 24 &#956;m were also used to investigate the properties of the source and its surroundings at different wavelengths. Results: The results show that the extended X-ray emission is predominantly soft (0.3-1.2 keV) and peaks around 0.5 keV, which shows that it is an extremely soft SNR. X-ray emission correlates very well with central regions of bright radio emission. On the west side the radio\/X-ray emission displays a plane-like feature with a terminal wall where strong infrared emission is detected. Our spatially resolved X-ray spectral analysis confirms that the emission is dominated by weak atomic emission lines of N, O, Ne, and Fe, all of them undetected in previous X-ray studies. These characteristics suggest that the X-ray emission is originated in an optically thin thermal plasma, whose radiation is well fitted by a non-equilibrium ionization collisional plasma (VNEI) X-ray emission model. Our study favors a scenario where G332.5-5.6 is expanding in a medium with an abrupt density change (the wall), likely a dense infrared emitting region of dust on the western side of the source.","palabras_clave":"ISM: INDIVIDUAL OBJECTS: G332.5-5.6|ISM: SUPERNOVA REMNANTS|X-RAYS: ISM|RADIATION MECHANISMS: THERMAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3047,"idioma_id":4,"titulo":"Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate Induced NF-&#954;B Activation in Melanoma Cells by Inhibition of Akt Signaling","resumen":"Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that regulates many processes in inflammation and cancer. S1P is a ligand for five G protein-coupled receptors, S1PR1-5, and also has important intracellular actions. Previously we have shown that intracellular S1P is involved in tumor necrosis factor alpha (TNF)-induced NF-kB activation in melanoma cell lines that express filamin A (FLNA). Here, we show that extracellular S1P activates NF-kB only in melanoma cells that lack FLNA. In these cells S1P, but not TNF, promotes IKK and p65 phosphorylation, IkBa degradation, p65 nuclear translocation and NF-kB reporter activity. NF-kB activation induced by S1P was mediated via S1PR1 and S1PR2. Exogenous S1P enhanced phosphorylation of PKC&#948; and its downregulation reduced S1P-induced phosphorylation of IKK and p65. In addition, silencing of Bcl10 also inhibited S1P-induced IKK phosphorylation. Surprisingly, S1P reduced Akt activation in melanoma cells that express FLNA, whereas in the absence of FLNA, high phosphorylation levels of Akt were maintained, enabling S1P-mediated NF-kB signaling. In accord, inhibition of Akt suppressed S1P-mediated IKK and p65 phosphorylation and degradation of IkBa. Hence, these results support a negative role of FLNA in S1P-mediated NF-kB activation in melanoma cells through modulation of Akt.","palabras_clave":"FILAMIN A|SPHINGOSINE-1-PHOSPHATE|CANCER|INFLAMMATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3048,"idioma_id":4,"titulo":"Adaptability-based Service Behavioral Assessment (Indexed Latindex)","resumen":"Building Service-oriented Applications implies the selection of adequate services to fulfill required functionality. Even a reduced set of candidate services involves an overwhelming assessment effort. In a previous work we have presented an approach to assist developers in the selection of Web Services. In this paper we detail its behavioral assessment procedure, which is based on testing and adaptation. This is done by using black-box testing criteria to explore services behavior. In addition, helpful information takes shape to build the needed adaptation logic to safely integrate the selected candidate into a Service-oriented Application. A concise case study shows the potential of this approach for both selection and integration of a candidate Web Service.","palabras_clave":"Web Services|Testing|Service-Oriented Computing|Service Selection"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3049,"idioma_id":5,"titulo":"Cooperación biofísico-bioquímica en el control direccional de la ?calidad estructural? ósea (resistencia a la fractura","resumen":"Parece natural que el desarrollo de la estructura resistiva de los huesos resulte de simples procesos aditivos\/sustractivos de material duro, con balances positivos o negativos dependientes de una adecuada nutrición\/insolación, sin necesidad de aludir a mecanismos que orienten esos procesos en el espacio. La misma explicación se aplicó a los efectos de todos los agentes osteoactivos. Esta concepción errónea ha afectado la interpretación, el diagnóstico y el tratamiento de las osteopatías fragilizantes durante más de 4 décadas. Los procesos referidos resultan todos de reacciones bioquímicas (sistémicas, no direccionales),pero también están orientados en el espaciopor otros factores, biofísicos (vectoriales,direccionales), que determinan la eficacia mecánicade los huesos, cuya comprensión esfundamental para el clínico. Cuatro factoreshan contribuido, entre otros, a esta confusión:el sentido común, la sucesión de algunas novedadesosteológicas trascendentes, la dificultadpara analizar la organización biológicade los esqueletos respetando los ?niveles decomplejidad estructural? clásicos en Biología,y determinantes de orden económico. Este artículopretende contribuir a vencer esas dificultadesinterpretativas, apoyado por algunosavances recientes que evidencian la participaciónde los osteocitos como elementos ?primarios?de la transducción biofísico-bioquímicaen el control biomecánico direccional de laspropiedades mecánicas óseas.","palabras_clave":"Biomecánica ósea|Osteocitos|mecanostato óseo|osteoporosis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3050,"idioma_id":4,"titulo":"Draft genome sequences of Escherichia coli O157: H7 strains Rafaela_II (clade 8) and 7.1_Anguil (clade 6) from cattle in Argentina","resumen":"Escherichia coli O157:H7 is a major etiologic agent of diseases in humans that cause diarrhea, hemorrhagic colitis, and hemolytic-uremic syndrome. Here, we report the draft genome sequences of two strains isolated from cattle that had high levels of Shiga toxin 2 and high lethality in mice.","palabras_clave":"Escherichia coli|Genome| O157:H7|Cattle"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3131,"idioma_id":4,"titulo":"The Caldenal ecosystem: effects of a prescribed burning on soil chemical properties","resumen":"Before and after a prescribed burning, the upper 2.5 cm of soil in patches of fodder, non fodder and shrub vegetation were sampled.  Then, bulk density, gravimetric moisture, pH in water, available phosphorus, exchangeable cations, cationic exchange capacity, total nitrogen, total, particulate and mineral organic carbon were determined. Maximum temperatures ranges reached over the ground during burning were measured to show the highest values registered in shrubs. Results showed that total, particulate and mineral organic carbon and total nitrogen contents and percent base saturation increased in all soils after burning, without differential effects being detected between vegetation patches. After burning, available phosphorus content increased both for forage and shrub patches. A Na+ content decrease was observed for all soils in the different patches while Mg2+ content increased. No changes in the other analyzed variables were observed. Prescribed burning, as studied in the present work, might improve the Caldenal soils? physical and chemical fertility, mainly due to an increase in labile organic matter and some nutrients essential for plant growth.","palabras_clave":"FIRE|SEMI-ARID REGION|SOIL FERTILITY|VEGETATION PATCH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3133,"idioma_id":4,"titulo":"Square wave voltammetry with multivariate calibration tools for determination of eugenol, carvacrol and thymol in honey","resumen":"Abstract The simultaneous determination of eugenol (EU), thymol (Ty) and carvacrol (CA) in honey samples, employing square wave voltammetry (SWV) and chemometrics tools, is informed for the first time. For this purpose, a glassy carbon electrode (GCE) was used as working electrode. The operating conditions and influencing parameters (involving several chemical and instrumental parameters) were first optimized by cyclic voltammetry (CV). Thus, the effects of the scan rate, pH and analyte concentration on the electrochemical response of the above mentioned molecules were studied. The results show that the electrochemical responses of the three compounds are very similar and that the voltammetric traces present a high degree of overlap under all the experimental conditions used in this study. Therefore, two chemometric tools were tested to obtain the multivariate calibration model. One method was the partial least squares regression (PLS-1), which assumes a linear behaviour. The other nonlinear method was an artificial neural network (ANN). In this last case we used a supervised, feed-forward network with Levenberg-Marquardt back propagation training. From the accuracies and precisions analysis between nominal and estimated concentrations calculated by using both methods, it was inferred that the ANN method was a good model to quantify EU, Ty and CA in honey samples. Recovery percentages were between 87% and 104%, except for two samples whose values were 136% and 72%. The analytical methodology was simple, fast and accurate.","palabras_clave":"ESSENTIAL OILS|CARVACROL|THYMOL|EUGENOL|HONEY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3137,"idioma_id":4,"titulo":"Spore morphology and wall ultrastructure of Lycopodiaceae from northwest Argentina","resumen":"Spores of Lycopodiaceae species growing in northwest Argentina were studied. The taxa are: subfam. Lycopodioideae: Austrolycopodium erectum, Diphasiastrum thyoides, and Lycopodium clavatum subsp. clavatum; subfam. Lycopodielloideae: Palhinhaea cernua; and subfam. Huperzioideae: Phlegmariurus mandiocanus, Phlegmariurus phylicifolius, Phlegmariurus reflexus, Phlegmariurus saururus, and Phlegmariurussotae. The study is based on herbarium material; spores were examined with light microscope (LM), scanning (SEM) and transmission electron microscope (TEM). Spores are trilete 24-44 &#956;m in equatorial diameter and 14-35 &#956;min polar diameter. The exospore is 0.5-9.5 &#956;mthick and one or two-layered, depending on the analyzed area of the spore. The ornamentation can be reticulate, rugulate, foveolate, fossulate orfoveolate?fossulate. The perispore is 30-190 nm thick, one or two-layered, and is only visible with TEM. The presence of this wall is mentioned and described for the first time in Phlegmariurus phylicifolius. In the studied species, spore ornamentation of the proximal face is different from or less complex than the distalface. The results evidence the significance of spore morphology in Lycopodiaceae systematics, particularly at subfamilial level.","palabras_clave":"Lycopodiaceae|Spore|Morphology|Ultrastructure|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3138,"idioma_id":4,"titulo":"Enterotoxigenic Escherichia coli Subclinical Infection in Pigs: Bacteriological, Genotypic Characterization and Antimicrobial Resistance Profiles","resumen":"In order to determine the prevalence of ETEC in healthy pigs, 990 animals from 11 pig farms were sampled. Using end-time PCR, ETEC were detected in 150 (15.2%) animals. From the positive samples 43 strains were isolated. From them, 39.5% were resistant to multiple antimicrobials and 9 of them carried the gene intI2 . The genotypes rfbO157\/estII\/aidA and estI\/estII were the most prevalent, 32.5% and 25.0%, respectively. The estII gene was identified most frequently (90.7%), followed by estI (34.9%), astA (25.6%) and eltA (11.6%). The genes coding the fimbriae F5, F6 and F18 were detected in single isolates each one. The aidA gene was detected in 20 ETEC associated with estII gene. ETEC belonged to 9 different serogroups, and 35.0% of them to serotype O157:H19. Isolates were associated by ERIC-PCR into 9 groups with 70.0% similarity. This is the first cross-sectional study conducted simultaneously in multiple farms to detect prevalence and characterization of ETEC from pigs without clinical signs of diarrhea performed in Argentina","palabras_clave":"ETEC|non-diarrheic pigs|serotypes|antimicrobial resistant"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3139,"idioma_id":4,"titulo":"Synthesis of the O-linked hexasaccharide containing &#946;-D-Galp-(1&#8594;2)-D-Galf in Trypanosoma cruzi mucins. Differences on sialylation by trans-sialidase of the two constituent hexasaccharides","resumen":"The hexasaccharide &#946;-D-Galp-(1&#8594;2)-[&#946;-D-Galp-(1&#8594;3)]-&#946;-D-Galp-(1&#8594;6)-[&#946;-D-Galp(1&#8594;2)-&#946;-D-Galf(1&#8594;4)]-D-GlcNAc (10) and its &#946;-D-Galf-(1&#8594;2)-&#946;-D-Galf containing isomer (7) are the largest carbohydrates in mucins of some strains of T. cruzi. The terminal &#946;-D-Galp units are sites of sialylation by the parasite trans-sialidase. Hexasaccharide 10 was chemically synthesized for the first time by a [3+3] nitrilium based convergent approach, using the trichloroacetimidate method of glycosylation. The 1H NMR spectrum of its alditol was identical to the spectrum of the product released by &#946;-elimination from the parasite mucin. The trans-sialylation reaction studied on the benzyl glycoside of 10 showed two monosialylated products whose relative abundance changed with time. On the other hand, only one product was produced by sialylation of the benzyl glycoside of 7. A preparative synthesis of the latter and spectroscopic analysis of the product unequivocally established the sialylation site at the less hindered (1&#8594;3)-linked galactopyranose.","palabras_clave":"Trypanosoma cruzi|mucins|trans-sialidase|glycosylation|galactofuranose|nitrilium|oligosaccharides"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3140,"idioma_id":4,"titulo":"New evidences of rupture of crust and mantle in the subducted Nazca plate at intermediate-depth","resumen":"Between 33°-36°S, Nazca plate subducts below South American plate with an angle of ~30°, and it is seismically active until ~200-280 km depth. At 33.5°S, the seismicity decreases drastically at 120 km depth, just below the volcanic arc. In this paper, we studied a pair of associated earthquakes located in the area where the frequency of seismicity changes. The hypocenters of the Mw=6.4, June 16th, 2000 and Mw=5.7 January 7th, 2003 earthquakes were found nearby, adjacent to the oceanic Moho, closely associated between each other. The slip on the plane of the 2000 event produced Coulomb stress changes on the fault plane of 2003, both westward dipping, with a variation from ~ 1 bar near the hypocenter of the latter to ~ 0.1 bars in the deepest part of the plane. The two earthquakes combined process describes a normal focal mechanism, which cuts through the crust and breaks the mantle, reaching depths of ~ 40 km below the Moho. The composed fault plane of the 2000 and 2003 events corresponds to a west-dipping normal fault with strike and dip consistent with those of the outer ridge faults. Thus, it can be a preexisting fault originated in that environment.The slip on the composed fault plane is consistent with the bending produced by the slab pull. Dehydration might add some contribution to the process.","palabras_clave":"Coulomb static stress|intermediate-depth seismicity|subducted Nazca plate|outer-rise faults"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3141,"idioma_id":4,"titulo":"Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient\/proficient colon cancer cell lines","resumen":"PURPOSE: Hyperthermia is used in combination with conventional anticancer agents to potentiate their cytotoxicity. One of its key events is the synthesis of heat shock proteins (HSPs), which are able to associate with components from DNA repair mechanisms. However, little is known about their relationship with the mismatch repair system (MMR). Our aim was to study the effects of hyperthermia on cisplatin (cPt) sensitivity and to determine whether MLH1 and MSH2 associate with Hsp27 and Hsp72 in MMR-deficient (-)\/-proficient (+) cells.  MATERIALS AND METHODS: HCT116+ch2 (MMR-) and HCT116+ch3 (MMR+) cell lines were exposed to cPt with or without previous hyperthermia (42&#8201;°C, 1&#8201;h). Clonogenic survival assays, MTT, confocal immunofluorescence, immunoprecipitation, immunoblotting and flow cytometry were performed.  RESULTS: Hyperthermia increased the cPt resistance in MMR- cells 1.42-fold.  Immunofluorescence revealed that after cPt, Hsp27 and Hsp72 translocated to the nucleus and colocalisation coefficients between these proteins with MLH1 and MSH2 increased in MMR+ cells. Immunoprecipitation confirmed the interactions between HSPs and MMR proteins in control and treated cells. Hyperthermia pretreatment induced cell cycle arrest, increased p73 expression and potentiated cPt sensitivity in MMR+ cells.  CONCLUSIONS: This is the first report showing in a MMR-\/+ cellular model that  MLH1 and MSH2 are client proteins of Hsp27 and Hsp72. Our study suggests that p73 might participate in the cellular response to hyperthermia and cPt in a MMR-dependent manner. Further functional studies will confirm whether HSPs cooperate with the MMR system in cPt-induced DNA damage response or whether these protein interactions are only the result of their chaperone functions.","palabras_clave":"HEAT SHOCK RESPONSE|HT RADIOCHEMOSENSITIZATION|DNA DAMAGE\/REPAIR|SIGNAL TRANSDUCTION|APOPTOSIS|SUPPRESSOR\/ONCOGENE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3142,"idioma_id":4,"titulo":"Corn starch systems as carriers for yerba mate (Ilex paraguariensis) antioxidants. Effect of mineral addition","resumen":"Corn starch is considered a good vehicle for delivering bioactive compounds such as supplements or health promoting additives. The ability of starch treated by high hydrostatic pressure (HHP) to bind and carry zinc and magnesium salts and natural antioxidants of yerba mate (Ilex paraguariensis) extracts was tested. A uniform distribution of the minerals on the surface of starch granules was observed by SEM-EDX and significantly higher amounts of minerals were loaded by HHP treated starches. Calorimetric analysis showed the effect of both HHP treatment and the active compounds addition, while crystal fraction was determined by X-ray diffraction, denoting the presence of minerals in the starch granule. It was found that the type of starch carrier did not affect total polyphenol loading. Besides, HPLC analysis showed that the relative composition of polyphenols from yerba mate extract was maintained. These results support the use of HHP treated corn starch as an alternative carrier for molecules of nutritional interest into food systems.","palabras_clave":"STARCH|HIGH HYDROSTATIC PRESSURE|MINERALS|NATURAL ANTIOXIDANTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3143,"idioma_id":4,"titulo":"Structural and spectroscopic characterization of isomorphous sodium, rubidium and cesium acesulfamates","resumen":"Three newacesulfamate salts, NaC4H4NO4S, RbC4H4NO4Sand CsC4H4NO4S, were prepared by reactions inaqueous solutions and thoroughly characterized. Their crystal and molecularstructures were determined by single crystal X-ray diffraction methods. Theycrystallize in the monoclinic space group P21\/a with&nbsp;a = 7.2518(2), b = 8.9414(4), c = 10.5929(4)Å, b = 99.951(3)° for the Na salt;&nbsp; a = 7.4663(3), b =9.6962(4), c = 10.4391(4) Å, &#946; = 95.150(3)º for the Rb salt and a = 7.5995(4), b =9.9439(4), c = 10.8814(6) Å, &#946; = 91.298(5) for the Cs salt, and &nbsp;Z = 4 molecules per unit cell. The threecompounds are isotypic to each other and to the previously reported potassiumsalt. The metal ions are in irregular polyhedral coordination with sixneighboring acesulfamate anions through their nitrogen and carbonyl andsulfoxide oxygen atoms. The FTIR spectra of the compounds were also recordedand are briefly discussed.&nbsp;","palabras_clave":"CESIUM ACESULFAMATE|CRYSTAL STRUCTURE|FTIR-SPECTRA|RUBIDIUM ACESULFAMATE|SODIUM ACESULFAMATE|SYNTHESIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3144,"idioma_id":4,"titulo":"Study of Oxidative Stress and Genotoxicity by Arsenic Contamination in Glycine max. L","resumen":"Introduction:Volcanism is an important natural origin of Arsenic (As) contamination. Aims:Oxidative stress parameters, antioxidant defense system, the expression oftranscripts involved in defense responses and the As genotoxicity wereanalyzed. Study Design:The plants were separated into two groups (Control and As-treated ones) untilthey were exposed to As (2.5 and 5 ppm) at day 10. Methodology:Biochemical, molecular and cytogenetic determinations were carried out. Results: Arsenic treated plants show growthabnormalities. The antioxidant defenses and oxidative parameters in roots andleaves showed different tissue- specific responses. Whereas leaf tissuesdisplay an active antioxidant defense, root cells are unable to produce defensemolecules and showoxidative stress. Moreover, the analysis of antioxidant enzymes such asascorbate peroxidase and superoxide dismutase, showed higher activity in leavesthan in roots, except for isocitrate dehydrogenase. The expression of GR andMAPK decreased significantly in all the treatments during the time curve. ICDHshowed an increase in its expression with 24 hours of treatment and falls at 72hours compared to their controls. Genotoxicity assays showed a decrease ofmitotic index (MI) and the presence of altered nucleus, in samples exposed for72 hours. Conclusion: Our results suggest that the physiological,biochemical, molecular and cytogenetic behavior of the plants depends on the Asconcentration and the length of the exposure.","palabras_clave":"ARSENIC|SOYBEAN|OXIDATIVE STRESS|ANTIOXIDANT DEFENSE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3145,"idioma_id":4,"titulo":"Structural, Spectroscopic and DFT Study of 4-methoxybenzohylhydrazide Schiff Bases. A New Series of Polyfunctional Ligands","resumen":"Five Schiff bases obtained from condensation of 4-methoxybenzohydrazide with related aldehydes, namely o-vanillin, vanillin, 5-bromovanillin, 5-chlorosalicylaldehyde and 5-bromosalicylaldehyde were prepared. A detailed structural and spectroscopic study is reported. The crystal structures of four members of the family were determined and compared with one another. The hydrazones obtained from 5-chlorosalicylaldehyde and 5-bromosalicylaldehyde resulted to be isomorphic to each other. The solid-state structures are stabilized by intra-molecular O-H···N interactions in salicylaldehyde derivatives between the O-H moiety from the aldehyde and the hydrazone nitrogen atom. All crystals are further stabilized by intermolecular H-bonds mediated by the crystallization water molecule. Acomparative analysis between experimental and theoretical results is presented. The conformational space was searched and geometries were optimized both in gas phase and including solvent effects. The structure is predicted for the compound for which the crystal structure was not determined. Infrared and electronic spectra were measured and assignedwith the help of data obtained from computational methods based on the Density Functional Theory.","palabras_clave":"-"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3146,"idioma_id":4,"titulo":"Predation on Philodryas patagoniensis (Squamata, Colubridae) by an Aplomado falcon (Falconidae: Falco femoralis) in central Argentina","resumen":"The Patagonia Green Racer (Philodryas patagoniensis, Squamata, Colubridae) is a widespread snake that occurs in Argentina, Brazil, eastern Bolivia and Uruguay (Cei, 1993). In Argentina this species ranges from northern (Formosa, Misiones, Corrientes, Salta, Jujuy, Tucumán, Santiago del Estero, Chaco and La Rioja) and central provinces (Mendoza, La Pampa, Córdoba, Santa Fe, Entre Ríos, San Luis) up to northern Patagonia (Neuquén, Rio Negro, Chubut) in the south (Cei, 1993). The Patagonian Green Racer is a medium-sized diurnal colubrid snake that exhibits a territorial behavior, and inhabits mainly open areas as grassland and savannas (Cei, 1993; Scolaro, 2005). Here we present a case of predation on the Patagonian Green Racer by an ornithophagus raptor, the Aplomado Falcon (Falconidae: Falco femoralis). The observation was made in an agricultural landscape from La Pampa province, in central Argentina, during bird?s reproductive season (austral spring). The area consists of a mosaic of different crops and farming lands. The Aplomado Falcon is a medium-sized (average 300 g) falcon of the Americas. This raptor is mainly ornithofagous, being the Ear doves (Zenaida auriculata) its major prey on the study area (Liébana, 2015). Until this report doesn?t exits evidence of depredation by Aplomado Falcon over Patagonian Green Racers or on any other species of Philodryas (Keddy-Hector, 2000; Figueroa and Corales, 2005; Bó et al., 2007; Baladrón et al., 2012). On 10 November 2010 we found remains of a Patagonian Green Racer in an Aplomado Falcon nest containing three nestlings, in Colonia Baron town (36°09&#8242;05&#8243; S, 63°51&#8242;14&#8243; W; 154 m a.s.l.). The snake remains were situated below the nest, the head and part of the body were possibly consumed by the falcons before falling down to the ground. This was the only occurrence of this prey item on 589 pellets and 278 prey remains analyzed. Remains of colubrid preys (scales) were found on three pellets but they couldn?t be identified to species level. Other reptiles founded in low frequency were Teius oculatus (n=3) and Lioalaemus sp. (n=11). All the reptile preys were identified using references collections and keys (Scolaro, 2005; Scrochi et al., 2010). It has been documented that P. patagoniensis is consumed by a variety of raptor species: the Laughing Falcon (Herpetotheres cachinnas) in Brazil, the Whitetailed Hawk (Buteo albicaudatus) and the Crowned Solitary Eagle (Harpyhialeaetus coronatus) in central Argentina, and it is also probably consumed by the Roadside Hawk (Buteo magnirostris) and the Savanna Hawk (Heterospizias meridionalis) in northern Argentina (De la Peña, 2001; Di Giácomo, 2005; Motta-Junior et al., 2010; Sarasola et al., 2010; Galmes unpublished data). The Patagonian Green Racer is very common in central Argentina; but information about its ecology and potential predators are scarce. Our record presents the Aplomado Falcon as an occasional predator on this colubrid snake.","palabras_clave":"Philodryas patagoniensis|predation|Falco femoralis|Aplomado falcon"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3147,"idioma_id":4,"titulo":"Bioactivities of Ketones Terpenes: Antifungal Effect on F. verticillioides and Repellents to Control Insect Fungal Vector, S. zeamais","resumen":"Maize is one the most important staple foods in the world. However, numerous pests, such as fungal pathogens, e.g., Fusarium verticillioides, and insects, such as Sitophlilus zeamais, attack maize grains during storage. Many F. verticillioides strains produce fumonisins, one of the most important mycotoxin that causes toxic effects on human and animal health. This situation is aggravated by the insect fungal vector, Sitophlilus zeamais, which contributes to the dispersal of fungal spores, and through feeding damage, provide entry points for fungal infections. The aim of this study was to evaluate in vitro bioassays, the antifungal activity on F. verticillioides M3125 and repellent effects against S. zeamais of ketone terpenes. In addition, we performed Quantitative structure?activity relationship (Q-SAR) studies between physico-chemical properties of ketone terpenes and the antifungal effect. Thymoquinone was the most active compound against F. verticillioides (Minimum Inhibitory Concentration, MIC: 0.87) affecting the lag phase and the growth rate showing a total inhibition of growth at concentration higher than 2 mM (p < 0.05). The Q-SAR model revealed that the antifungal activity of ketone compounds is related to the electronic descriptor, Pi energy. Thymoquinone showed a strong repellent effect (&#8722;77.8 ± 8.5, p < 0.001) against S. zeamais. These findings make an important contribution to the search for new compounds to control two stored pests of maize.","palabras_clave":"F. verticillioides|S. zeamais|&#945;,&#946;-unsaturated ketones|Q-SAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3148,"idioma_id":4,"titulo":"Maize consumption in pre-Hispanic south-central Andes: chemical and microscopic evidence from organic residues in archaeological pottery from western Tinogasta (Catamarca, Argentina)","resumen":"Pre-Hispanic Andean societies depended economically on the cultivation of maize (Zea mays), the main  staple food crop in the region after its introduction from highland Mexico. Here we report new data from  residue analysis of potsherds recovered in archaeological sites in western Tinogasta, Catamarca province,  Argentina, ca. 3rd to 16th centuries AD. Molecular and isotopic (d13C values) compositions of fatty acids  and microscopically identified maize starch granules from organic residues absorbed in archaeological  potsherds were compared with Andean ingredients and food residues obtained from experimental  replica pots, where traditional recipes were cooked. Complex mixtures of lipids and starch remains  observed in archaeological cooking pots indicated combinations of Andean ingredients such as llama,  beans, algarroba, and maize, and suggest continuity in the domestic foodways through time. The distribution  and d13C values of lipids preserved in vessels used for alcoholic beverage preparation, storage  and transport in Inka sites suggested the possible consumption of two drinks with distinct patterns:  traditional Andean maize beer (chicha) and a local fermented drink made from algarroba flour (aloja).  This is potential evidence for consumption practices in festive contexts sponsored by the Inka state.","palabras_clave":"ORGANIC RESIDUES|POTSHERDS|COOKING PRACTICES|FOOD AND BEVERAGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3254,"idioma_id":4,"titulo":"A HIGH-FAT PLUS FRUCTOSE DIET PRODUCES A VASCULAR PROSTANOID ALTERATIONS IN THE RAT","resumen":"SUMMARY&nbsp;&nbsp;&nbsp; 1)&nbsp;&nbsp; &nbsp;A high-fat plus fructose diet produces in the rat cardiovascular and metabolic alterations that resemble human metabolic syndrome. Prostanoids (PR), cyclooxygenase-derived arachidonic acid metabolites, have vasoactive properties and mediate inflammation.&nbsp;&nbsp; 2)&nbsp;&nbsp; &nbsp;The aim of this study was to analyze the effect of that diet on blood pressure (BP), metabolic parameters and mesenteric vascular bed PR production in male Sprague-Dawley rats.&nbsp;&nbsp; 3)&nbsp;&nbsp; &nbsp;Four groups were studied during 9 weeks (n=6 each): Control (C), standard diet (SD) and tap water to drink; Fructose (F), SD and 10% w\/v F solution to drink; high-fat (HF), 50% (w\/w) bovine fat added to SD and tap water; and HFF, both treatments. PR were determined by HPLC.&nbsp;&nbsp; 4)&nbsp;&nbsp; &nbsp;BP was elevated in all experimental groups. Triglyceridemia, insulinemia and HOMA-IR were increased in the F and HF groups. HFF animals showed elevated glycemia, insulinemia, HOMA-IR and triglyceridemia. F decreased the vasodilator prostanoids PGI2&nbsp; and PGE2 in the mesenteric vascular bed. Body weight was not significantly altered. In HFF, production of PGE2, PGF2alpha and TXB2, were elevated.&nbsp;&nbsp; 5)&nbsp;&nbsp; &nbsp;The increased BP in HF and HFF could be partly attributed to the imbalance in vascular PR production towards vasoconstrictors. On the other hand, this dietary modification implies an inflammatory process, which could explain the elevation of PGE2, a well-known mediator of inflammation. In the F group, the hypertension could be related to the decreased vasodilator PR.&nbsp;&nbsp; 6)&nbsp;&nbsp; &nbsp;The simultaneous administration of HF and F in the rat produces deleterious effects more marked than those of each treatment separately.","palabras_clave":"METABOLIC SYNDROME|PROSTANOIDS|BLOOD PRESSURE |FRUCTOSE OVERLOAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3255,"idioma_id":4,"titulo":"Nitric oxide is reduced to HNO by proton-coupled nucleophilic attack (PCNA) by ascorbate, tyrosine, and other alcohols. A new route to HNO in biological media?","resumen":"The role of NO in biology is well established. However, increasing body of evidence suggests that azanone (HNO), could also be involved in biological processes, some of which are attributed to NO. In this context, one of the most important and yet unanswered questions is whether and how HNO is produced in vivo. A possible route concerns the chemical or enzymatic reduction of NO. In the present work, we have taken advantage of a selective HNO sensing method, to show that NO is reduced to HNO by biologically relevant alcohols with moderate reducing capacity, such as ascorbate or tyrosine. The proposed mechanism involves a nucleophilic attack to NO by the alcohol, coupled to a proton transfer (PCNA: proton-coupled nucleophilic attack) and a subsequent decomposition of the so produced radical, to yield HNO and an alcoxyl radical.","palabras_clave":"HNO|NO|interconvertion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3256,"idioma_id":4,"titulo":"Foot-and-mouth disease vaccination induces cross-reactive IFN-&#61543;  responses in cattle that are dependent on the integrity of the 140S particles","resumen":"Interferon-Gamma (IFN-g) recall responses against foot-and-mouth disease virus (FMDV) in FMD vaccinated cattle are utilized to study T-lymphocyte immunity against this virus. In this report, a recall IFN-g assay based on a commercial ELISA was set up using 308 samples obtained from naïve and vaccinated cattle. Further, the assay was used to study cross-reactive responses between different FMDV vaccine strains. Blood samples from cattle immunized with monovalent vaccines containing A24\/Cruzeiro\/Brazil\/55 (A24\/Cruzeiro), A\/Argentina\/2001 (A\/Arg\/01) or O1\/Campos\/Brazil\/58 (O1\/Campos) strains were tested using purified FMDV from homologous and heterologous strains. FMDV-induced IFN-&#61543; production was fully dependent on the quantity and structural integrity of the stimulating antigen. A24\/Cruzeiro strain was the most efficient IFN-g inducer in all vaccinated animals for heterologous and homologous virus, both when included in the vaccine or as stimulating antigen. Accordingly, A24\/Cruzeiro 140S particles were more stable than O1\/Campos particles. These results show that IFN-g production relies on the presence of whole FMDV particles that can maintain their integrity along the incubation process, for in vitro use; and throughout the vaccine´s shelf-life, when utilized in vivo.","palabras_clave":"FMDV |FMD vaccines |IFN-&#947; |Capsid integrity |Cattle"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3257,"idioma_id":4,"titulo":"Biomass towards fine chemical products: Oxidation of a-pinene over sieves nanostructured modified with vanadium","resumen":"Vanadium-containing molecular sieves (V-M(x)) were synthetized and applied as heterogeneous cata-lysts for the liquid phase oxidation of -pinene with hydrogen peroxide at 70&#9702;C. It has been found thatthe vanadium content in V-M(x) materials affected the conversion of -pinene and product distribution.The turnover numbers increased strongly with the decreasing of V content probably caused by a high Vdispersion. The major products were verbenone, trans-sobrerol and campholenic aldehyde. The acid?baseproperties of V-M(x) affected the distribution of products formed via the isomerization of -pinene oxideover Lewis acid sites to campholenic aldehyde while Bronsted acid sites brought about the formationof 1,2 pinanediol and trans-sobrerol by hydrolysis and by the opening of oxirane ring. The increase inV content in V-M(x) led to the increase in campholenic aldehyde, 1,2 pinanediol, trans- sobrerol andover oxidation products. Moreover, the effect of several solvents on the reaction oxidation was studied.The results showed that the highest -pinene conversions are obtained in the following order: acetoni-trile > ethanol > isoamyl alcohol > methyl ethyl ketone. Thus, using aprotic solvents, the catalytic activitywas increased and the formation of alkyl glycol ethers as by-product was not observed.","palabras_clave":"BIOMASS|OXIDATION|SIEVES NANOSTRUCTURED"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3258,"idioma_id":4,"titulo":"Combined effects of arbuscular mycorrhizal fungi and exogenous cytokinins on pomegranate (Punica granatum) under two contrasting water availability conditions","resumen":"Abstract To our knowledge, there are no studies on the interactive effects of inoculation with arbuscular mycorrhizal fungi and cytokinin addition to plants under drought stress. We investigated the potential protective effect of arbuscular mycorrhizae on pomegranate plants, combined with exogenous cytokinin addition, under two contrasting soil wáter availability regimes. Our results showed that exogenous cytokinin addition enhances plant biomass, shoot to root ratio and wáter content, as well as increasing the anthocyanin content. However, a combination of AM fungal inoculation and cytokinin addition did not result in a synergistic protective effect against wáter stress. Plants were equally well protected against this stress by cytokinin spraying alone. The improvement of pomegranate growth was due mainly to exogenous cytokinin addition. Photosynthesis was promoted both by mycorrhizal inoculation alone and by exogenous cytokinin addition. The main protection against oxidative stress caused by drought was via enhanced accumulation of anthocyanins when the plants were sprayed with cytokinins. When cytokinins were used, the photosynthesis apparatus was also protected.","palabras_clave":"ARBUSCULAR MYCORRHIZAL FUNGI|SECONDARY METABOLITES|OXIDATIVE STRESS|CATALASE|SUPEROXIDE DISMUTASE|POMEGRANATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3259,"idioma_id":4,"titulo":"Regulatory Dendritic Cells Restrain NK Cell IFN- &#947; Production through Mechanisms Involving NKp46, IL-10, and MHC Class I&#8722; Specific Inhibitory Receptors","resumen":"Cross-talk between mature dendritic cells (mDC) and NK cells through the cell surface receptors NKp30 and DNAM-1 leads to their reciprocal activation. However, the impact of regulatory dendritic cells (regDC) on NK cell function remains unknown. As regDC constrain the immune response in different physiological and pathological conditions, the aim of this work was to investigate the functional outcome of the interaction between regDC and NK cells and the associated underlying mechanisms. RegDC generated from monocyte-derived DC treated either with LPS and dexamethasone, vitamin D3, or vitamin D3 and dexamethasone instructed NK cells to secrete lower amounts of IFN-&#947; than NK cells exposed to mDC. Although regDC triggered upregulation of the activation markers CD69 and CD25 on NK cells, they did not induce upregulation of CD56 as mDC, and silenced IFN-&#947; secretion through mechanisms involving insufficient secretion of IL-18, but not IL-12 or IL-15 and\/or induction of NK cell apoptosis. Blocking experiments demonstrated that regDC curb IFN-&#947; secretion by NK cells through a dominant suppressive mechanism involving IL-10, NK cell inhibitory receptors, and, unexpectedly, engagement of the activating receptor NKp46. Our findings unveil a previously unrecognized cross-talk through which regDC shape NK cell function toward an alternative activated phenotype unable to secrete IFN-&#947;, highlighting the plasticity of NK cells in response to tolerogenic stimuli. In addition, our findings contribute to identify a novel inhibitory role for NKp46 in the control of NK cell function, and have broad implications in the resolution of inflammatory responses and evasion of antitumor responses.","palabras_clave":"DENDRITIC CELLS|NK CELLS|REGULATION|INTERFERON GAMMA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3261,"idioma_id":4,"titulo":"Preliminary studies of new strains of Trametes sp. isolated from argentina for laccase production ability","resumen":"Oxidative enzymes secreted by white rot fungi can be applied in several technological processeswithin the paper industry, biofuel production and bioremediation. The discovery ofnative strains from the biodiverse Misiones (Argentina) forest can provide useful enzymesfor biotechnological purposes. In this work, we evaluated the laccase and manganese peroxidasesecretion abilities of four newly discovered strains of Trametes sp. that are nativeto Misiones. In addition, the copper response and optimal pH and temperature for laccaseactivity in culture supernatants were determined.The selected strains produced variable amounts oflaccase and MnP; whenCu2+ was added,both enzymes were significantly increased. Zymograms showed that two isoenzymes wereincreased in all strains in the presence of Cu2+. Strain B showed the greatest response toCu2+ addition, whereas strain A was more stable at the optimal temperature and pH. StrainA showed interesting potential for future biotechnological approaches due to the superiorthermo-stability of its secreted enzymes","palabras_clave":"WHITE ROTE FUNGI|LACCASE|TRAMETES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3329,"idioma_id":4,"titulo":"REMOVAL OF PHENOL BY IMMOBILIZATION OF TRAMETES VERSICOLOR IN SILICA-ALGINATE-FUNGUS BIOCOMPOSITES AND LOOFA SPONGE. CONTRIBUTION OF LIGNINOLYTIC ENZYMES TO THE PROCESS","resumen":"White-rot fungi have potential in organ pollutant degradation. Immobilization of microorganisms  has been successfully used for bioremediation. In this work, isolates of Argentinean white-rot fungi were tested for their tolerance towards up to10 mM phenol in agar plates. Seven isolates were further evaluated for their ability to grow onplates with 2,6-dimethoxyphenol, gallic acid,  2,4-dichlorophenol or guaiacol (7.5 mM), or with phenol as sole carbon source. Best results were obtained with Trametes versicolor, Irpex lacteus, Lentinus tigrinusand Pleurotus lindquistii. The ability of immobilized cultures of T. versicolor BAFC 2234 to remove phenol, was studied.     Silica-alginate-fungus-biocomposites resulted in phenol removal (10 mM) of up to 48% within 14 days. Immobilized on Luffa aegyptica, it removed between 62% and 74% of phenol (15 mM)  in 3 repeated cycles over a period of 23 days. Laccase was the main oxidative enzyme activity detected, and the purified enzyme oxidized in vitro 84% of phenol (0.5 mM) within 4 h, while 43% was converted by a purified Mn-peroxidase. Phenol phytotoxicity decreased noticeably. The  14   concentrations of phenol removed are amongst the highest reported so far, thus this strain of T. versicolor may have good prospects for application in industrial wastewater treatment.","palabras_clave":"biocomposites|laccase|Mn-peroxidase|phenolics|white-rot fungi|immobilization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3332,"idioma_id":5,"titulo":"LAS PLANTAS VASCULARES DEL PARQUE NACIONAL MBURUCUYÁ: NOMBRES VERNÁCULOS Y USOS (BRASSICACEAE)","resumen":"En el presente trabajo se presenta un catálogo completo de las plantas que habitan en esta reserva, junto con sus sinónimos, nombres comunes, el ambiente en que crecen, usos o utilidades de las especies y ejemplares testigo de cada taxón colectado. En total se registraron 1405 especies de plantas vasculares, 48 Pteridófitas (3,41%) y 1357 Angiospermas (96,59%). Entre las especies que viven en el área, 110 corresponden a entidades exóticas (7,82%), de las cuales 49 (44,54%) son estrictamente cultivadas, 47 (42,72%) son adventicias y 14(12,72%) naturalizadas en Argentina. Numerosas especies son empleadas para diversos fines, ya sea en forma tradicional o industrial. En total existen 619 especies que tienen algún tipo de aplicación, lo cual representa el 44,05% de las entidades registradas en el área. Entre éstas, son más frecuentes las empleadas en medicina popular o tradicional, que totalizan 303 especies (48,94%) de las entidades con usos o aplicaciones, seguido por las forrajeras (116spp., 18,73%), ornamentales (74 spp., 11,95%), alimenticias (50 spp., 8,07%) y forestales (36spp., 5,81%), entre otras.","palabras_clave":"ARGENTINA|CATÁLOGO DE PLANTAS VASCULARES|PARQUE NACIONAL MBURUCUYÁ|USOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3335,"idioma_id":4,"titulo":"In vivo antioxidant activity of grape, pomace and wine from three red varieties grown in Argentina. Its relationship to phenolic profile.","resumen":"The in vivo antioxidant capacity (AC) of natural antioxidants involved in the winemaking of three red grape varieties grown in Argentina and its association with the phenolic composition were studied. Polyphenols from grape, wine and pomace were capable of rescuing yeast cells from oxidative stress, probably by the induction of antioxidant enzymes, such as glutathione reductase (GR) and glutathione peroxidase (GPx). Observed AC was highly correlated with phenolic profiles, as shown by canonical correlation analysis (CCA) and multipleregression analysis (MRA). Grape samples showed the highest activity among sample types, and according to MRA kaempferol-3-glucoside and fertaric acid contributed positively, whereas ethyl gallate contributed negatively to AC of wines and pomaces.With respect to varieties, Syrah was the one with the highest activity, owing to higher contents of anthocyanins, compounds highly related to bioactivity.","palabras_clave":"ANTIOXIDANTES|UVA|VINO|POLIFENOLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3336,"idioma_id":4,"titulo":"Paleomagnetism of Mesozoic magmatic bodies of the Fuegian Cordillera: Implications for the formation of the Patagonian Orocline","resumen":"It is not known whether the Patagonian Orocline, i.e. the major bend of the southern Andes at the southern tip of South America, is a primary or secondary feature. Paleomagnetic data along the Patagonian Orocline are still too scarce to provide a reliable and unambiguous answer to this question. New paleomagnetic results on Late Jurassic to Late Cretaceous magmatic units along the central segment of the Fuegian Cordillera are reported. Data from four Late Cretaceous small intrusions and three sites on Late Jurassic-Early Cretaceous metabasalts and metagabbros showed  counterclockwise (ccw) declination deviations between 21° and 46° with respect to South America. From these and previous data a picture of a nearly homogeneous post- Late Cretaceous regional rotation of the central Fuegian Cordillera is suggested. This supports a model of nearly 30° of ccw secondary bending of the Patagonian Orocline since the Late Cretaceous (72 Ma). Lack of rotation of post-50 Ma sedimentary rocksexposed to the north of our study region, and larger rotations (of around 90°) reported to the south of it suggest that a geographical and\/or temporal progression of rotation values from south to north in the Fuegian part of the Patagonian Orocline should be investigated.","palabras_clave":"Paleomagnetism|Mesozoic|Fuegian Cordillera|Patagonian Orocline"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3337,"idioma_id":4,"titulo":"Amplitude and phase retrieval in simultaneous pi\/2 phase-shifting heterodyne interferometry using the synchrosqueezing transform","resumen":"This paper presents a method for amplitude and phase retrieval in simultaneous pi\/2 phase-shifting heterodyne interferometry. The used optical setup admits the introduction of a temporal carrier and simultaneously verifies the two-beam interferometry equation for each intensity signal, which are pi\/2 rad out of phase (quadrature). The spatiotemporal recovering process is obtained by isolating the object amplitude and phase using wavelet transform analysis of the temporal series composed by the difference between the measured pixel intensities corresponding to each quadrature signal. This process is subsequently improved by introducing a framework based on the synchrosqueezing transform, which recovers the data of interest with higher accuracy when very low scattering amplitudes and phase excursions must be determined in noisy working conditions. The advantages and limitations of the presented method are analyzed and discussed using numerical simulations and also experimental data  obtained from temporal speckle pattern interferometry.","palabras_clave":"Procesamiento de imágenes|Recuperación de fase óptica|Interferometría|Imágenes de speckle"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3338,"idioma_id":4,"titulo":"Interferon-&#946; gene transfer induces a strong cytotoxic bystander effect on melanoma cells","resumen":"FFFFFFFFF","palabras_clave":"DDD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3339,"idioma_id":4,"titulo":"Effect of water activity and temperature on growth of Aspergillus carbonarious and Aspergillus tubingensis and their itneractions on ochratoxin A production","resumen":"Aspergillus section Nigri are described as the main source of ochratoxin A (OTA) contamination in grapes and wine worldwide. The grape-growing area in Argentina has a wide latitudinal extension with ecological variations that allow the classification of well-demarcated regions. The aims of this study were: to determine the effect of eco-physiological parameters on growth of Aspergillus tubingensis and Aspergillus carbonariusand to evaluate the interaction between these species on OTA production in synthetic grape juice medium under different water activity (aw) and temperature conditions. The results showed that optimal growth conditions for A. tubingensis and A. carbonarius were 0.980 aw and 28 °C, however A. tubingensis grew faster than A. carbonarius at all temperatures and aw tested. OTA production by A. carbonarius was favoured at 20 °C and 0.950-0.965 aw, during 14 days of incubation. The effect of A. tubingensis on OTA production byA. carbonarius was mainly dependent on temperature. At 35 °C, A. tubingensis reduced the OTA production while this effect was not observed at 20 °C. More OTA could be produced as a defence reaction against fungal competitors to maintain niche colonisation, but in this study no effects by a related species were observed.","palabras_clave":"ASPERGILLUS SECTION NIGRI|SGM MEDIUM|FUNGAL INTERACTION|ECOPHYSIOLOGICAL CONDITIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3340,"idioma_id":4,"titulo":"The autophagic- lysosomal pathway determines the fate of glial cells under manganese- induced oxidative stress conditions","resumen":"Manganese (Mn) overexposure is frequently associated with the development of a neurodegenerative disorder known as Manganism. The Mn- mediated generation of reactive oxygen species (ROS) promotes cellular damage, finally leading to apoptotic cell death in rat astrocytoma C6 cells. In this scenario, the autophagic pathway could play an important role in preventing cytotoxicity. In the present study, we found that Mn induced an increase in the amount and total volume of acidic vesicular organelles (AVOs), a process usually related to the activation of the autophagic pathway. Particularly, the generation of enlarged AVOs was a ROS- dependent event. In this report we demonstrated for the first time that Mn induces autophagy in glial cells. This conclusion emerged from the results obtained employing a battery of autophagy markers: a) the increase in LC3-II expression levels, b) the formation of autophagic vesicles labeled with monodansylcadaverine (MDC) or LC3 and, c) the increase in Beclin 1\/ Bcl-2 and Beclin 1\/ Bcl-XL ratio. Autophagy inhibition employing 3-MA and mAtg5K130R resulted in decreased cell viability indicating that this event plays a protective role in Mn- induced cell death. In addition, mitophagy was demonstrated by an increase in LC3 and TOM-20 colocalization. On the other hand, we proposed the occurrence of lysosomal membrane permeabilization (LMP) based in the fact that cathepsins B and D activities are essential for cell death. Both cathepsin B inhibitor (Ca-074 Me) or cathepsin D inhibitor (Pepstatin A) completely prevented Mn- induced cytotoxicity. In addition, low dose of Bafilomycin A1 showed similar effects, a finding that adds evidence about the lysosomal role in Mn cytotoxicity. Finally, in vivo experiments demonstrated that Mn induces injury and alters LC3 expression levels in rat striatal astrocytes. In summary, our results demonstrated that autophagy is activated to counteract the harmful effect caused by Mn. These data is valuable to be considered in future research concerning Manganism therapies.","palabras_clave":"AUTOFAGIA|ASTROCITOS|LISOSOMAS|PARKINSONISMO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3341,"idioma_id":4,"titulo":"New host plants records for the froghopper Notozulia entreriana (Hemiptera: Cercopidae) with new data on its occurrence in diverse ecological zones in Argentina","resumen":"Froghoppers are one of the most important assemblies affecting farming and cattle rising in the Neotropical region because they attack a wide range of forage species and cause a considerable deterioration in the quality of pastures that sustain livestock production, particularly in northern and central Argentina. In this country, there are only a few taxonomic contributions dating back to early past century do exist. Notozulia entreriana Berg  is one of the most common spittlebug species inhabiting the subtropical region of South America country but it was previously cited is a few  localities. Throughout the study of specimens housed in an entomological collection and field captured specimens, the distributional range in Argentina, host plants  and other  associated plants we recordeds and regis. We enlarged the distribution of N. entreriana to eight different provinces; therefore, this species, which was known only for Pampa, Yungas and Chaco, also inhabits in Prepuna, Parana Forest and Monte biogeographic provinces. Its populations are associated to the following monocots: sugar cane, pangola grass, guinea grass, Johnson grass, Rhodes grass and Bermuda grass, but we stated that Bermuda grass, Johnson grass and Rhodes grass are true ?Host-plants?, where this froghopper completes its immature to adult life cycle.","palabras_clave":"AUCHENORRHYNCHA|HOST PLANT|GEOGRAPHICAL DISTRIBUTION|GRASS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3342,"idioma_id":4,"titulo":"Tuning the target composition of amine-grafted CPO-27-Mg for capture of CO 2 under post-combustion and air filtering conditions: a combined experimental and computational study","resumen":"A computational and experimental screening of hypothetical and real compounds exhibiting different degrees of ethylenediamine grafted to the CPO-27-Mg or Mg-DOBDC skeleton is performed in order to determine the target composition that optimizes the CO2 adsorption properties under flue gas and air filtering conditions. On the basis of the [Mg2(dobdc)] formula, eighteen hypothetical models involving 15?100% of functionalization of the coordinatively unsaturated sites (CUS) were considered by means of Grand Canonical Monte Carlo simulations to evaluate the CO2 adsorption at 298 K. In addition, post-synthesis modification was applied to CPO-27-Mg leading to three kinds of samples exhibiting 15, 50, and 60% of CUS functionalization with ethylenediamine, named CPO-27-Mg-a, CPO-27-Mg-b and CPO-27-Mg-c. Compounds were characterized using elemental analysis, TGA, FTIR spectroscopy, PXRD and DSC. Finally, bare and functionalized CPO-27-Mg materials were evaluated using gas adsorption and microcalorimetry in the 0.001?1 bar range, which is pertinent for the mentioned applications. Valuable information related to design criteria for synthesis of tuned CO2 adsorbents is derived through this computational and experimental investigation.","palabras_clave":"CPO|post-combustion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3343,"idioma_id":4,"titulo":"Mid Holocene radiocarbon ages in the Subtropical Andes (~29° to 35° S), climatic change and implications on human space organization","resumen":"Long-term comparative research has been carried out in a wide latitudinal range of the Andes extending from 29° to 37° south, encompassing selected areas that differ in ecological, biogeographical, and archaeological levels. This latitudinal span shows diversity in subsistence modes across time and space, ranging from Andean agro-pastoralists in the north to Patagonian hunter-gatherers in the south. As part of this research, a program of geochemical and archaeological characterization of obsidian sources and distributions is being developed, attempting to assess connections between different biogeographical conditions. This work has allowed recognizing five Andean sources with different geological and topographical properties. Stemming from this macro-regional endeavor, in this paper we present a comparative analysis of the human use of two sources that, based on the intensity of human use on a macro-regional scale, can be interpreted as ?minor? sources. This study is framed on GIS least-cost models for human circulation across rugged landscapes allowing access to the sources. We assess temporal and spatial patterns of human occupation of high-altitude Andean deserts and neighboring areas comparing two of obsidian sources: Laguna del Diamante (34° S) and Cerro Huenul (36° S). The results indicate the existence of asymmetric distributions, particularly in the case of Laguna del Diamante. This evidence is used to assess the existence of dominant geographic vectors of human access and use of the Andean highlands. On this basis, we explore the analytical potential of minor sources for the study of human biogeography and organization of technology.","palabras_clave":"MID HOLOCENE|RADIOCARBON|SUBTROPICAL ANDES|CLIMATIC CHANGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3344,"idioma_id":4,"titulo":"Density functional theory based-study of 5-fluorouracil adsorption on &#946;-cristobalite       (111) hydroxylated surface: the importance of H-bonding interactions","resumen":"Silica-based mesoporous materials have been recently proposed as an efficient support for the controlled release of a popular anticancer drug, 5-fluorouracil (5-FU). Although the relevance of this topic, the atomistic details about the specific surface-drug interactions and the energy of adsorption are almost unknown. In this work, theoretical calculations using the Vienna Ab-initio Simulation Package (VASP)applying Grimmes D2 correction were performed to elucidate the drug-silica interactions and the host properties that control 5-FU drug adsorption on beta-cristobalite (1 1 1) hydroxylated surface. This study shows that hydrogen bonding, electron exchange, and dispersion forces are mainly involved to perform the 5-FU adsorption onto silica. This phenomenon, revealed by favorable energies, results in optimum four adsorption geometries that can be adopted for 5-FU on the hydroxylated silica surface. Silanols are weakening in response to the molecule approach and establish H-bonds with polar groups of 5-FU drug. The final geometry of 5-FU adopted on hydroxylated silica surface is the results of H-bonding interactions which stabilize and fix the molecule to the surface and dispersion forces which approach it toward silica(1 1 1) plane. The level of hydroxylation of the SiO2(1 1 1) surface is reflected by the elevated number of hydrogen bonds that play a significant role in the adsorption mechanisms.","palabras_clave":"H-bond interaction|5-Fluorouracil|hydroxylated silica|drug delivery"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3430,"idioma_id":4,"titulo":"Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid.","resumen":"Numerous reports have demonstrated a tumor inhibitory effect of polyunsaturated fatty acids (PUFAs). However, the molecular mechanisms modulating this phenomenon are in part poorly understood. Here, we provide evidence of a novel antitumoral mechanism of the PUFA arachidonic acid (AA). In vivo and in vitro experiments showed that AA treatment decreased tumor growth and metastasis, and increased apoptosis. Molecular analysis of this effect showed significantly reduced expression of a subset of antiapoptotic proteins, including BCL2, BFL1\/A1 and 4-1BB, in AA-treated cells. We demonstrated that downregulation of the transcription factor GLI1 in AA-treated cells is the underlying mechanism controlling BCL2, BFL1\/A1 and 4-1BB expression. Using luciferase reporters, chromatin immunoprecipitation, and expression studies, we found that GLI1 binds to the promoter of these antiapoptotic molecules, and regulates their expression and promoter activity. We provide evidence that AA-induced apoptosis and downregulation of antiapoptotic genes can be inhibited by overexpressing GLI1 in AA-sensitive cells. Conversely, inhibition of GLI1 mimics AA treatments, leading to decreased tumor growth, cell viability and expression of antiapoptotic molecules. Further characterization showed that AA represses GLI1 expression by stimulating NFATc1 nuclear translocation, which then binds the GLI1 promoter and represses its transcription. AA was shown to increase reactive oxygen species. Treatment with antioxidants reduced the AA-induced apoptosis, downregulation of GLI1 and NFATc1 activation, indicating that NFATc1 activation and GLI1 repression require the generation of reactive oxygen species. Collectively, these results define a novel mechanism underlying AA antitumoral functions that may serve as a foundation for the future PUFA-based therapeutic approaches.","palabras_clave":"T CELLS-DEPENDENT |GLI1|INHIBITORY|ARACHIDONIC ACID"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3431,"idioma_id":4,"titulo":"Neuroanatomy of Gryposuchus neogaeus (Crocodylia, Gavialoidea): a first integral  description of the braincase and endocranial morphological variation in extinct and  extant gavialoids","resumen":"Morphologicalstudies of the braincase and cranial endocast of fossil crocodylians, especially gavialids, are scarce. Here wepresent a detailed description of the neuroanatomy of Gryposuchus neogaeus fromthe Miocene of Argentina based on CT scans. The cranial endocast issub-horizontal and the angle formed between the mid-brain and the hind-brain ispoorly marked. When compared with Gavialis gangeticus, the mid-brain of G.neogaeus is relatively shorter, although the distribution of cranial nervesis similar. In the floor of the endocranial cavity, posterior to the dorsum sellae, there is a median foramen thatleads into a canal that runs anteroventrally through the basisphenoid topenetrate the posterior wall of the pituitary fossa (open foramen for thebasilar artery?). The same structure is present in G. gangeticus but is absentin other living crocodylians, suggesting a potentialsynapomorphy of Gavialoidea. The pneumaticity of the skull roof and thelateral branches of the pharyngotympanic system inG. neogaeus are markedly reduced when compared with the extant species. Comparisonswith the living Gavialis indicate that the pattern of braincasemorphology of Gavialidae was present in the Miocene; however, the internalmorphology, including brain shape, pneumaticity of the skull roof andbasicranium is different in the two species. This work is the first step tounderstand the variation of the neuroanatomy in this group ofarchosaurs and its palaeobiological implication","palabras_clave":"BRAINCASE    |CRANIAL ENDOCAST|GAVIALOIDEA|INNER EAR|MIOCENE|PNEUMATICITY|PALAEOBIOLOGY|GRYPOSUCHUS NEOGAEUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3432,"idioma_id":5,"titulo":"Registro del cultivar Antonio UNLPam","resumen":"Deriva del cruzamiento original CIMMYT 150.83\/ SONNI:6-SWTY91.13-6FM-0FM. Fue seleccionado para uso forrajero de doble propósito (pasto y grano) en la Facultad de Agronomía y Veterinaria de la UN Río Cuarto. Se efectuó la selección individual en F7 en Río Cuarto (Córdoba). El comportamiento forrajero para doble propósito se probó en ECR durante 5 años en Santa Rosa, La Pampa y Río Cuarto. Antonio-UNLPam se fundó a partir de una planta individual de C95\/46. Los resultados de  producción de pasto y grano lo hacen apto para emplear en la región pampeana semiárida-subhúmeda pampeana. Entrega 48% de la producción en el primer corte, y 35% y 16% en el segundo y tercer corte. Hábito de crecimiento intermedio, porte juvenil semierecto, de vigoroso crecimiento inicial y buen comportamiento sanitario durante todo el ciclo de aprovechamiento forrajero. Presenta el hombro de la gluma inclinado y el relieve dorsal del cariopse convexo. La fecha de siembra más adecuada para la producción de forraje en la región subhúmeda-semiárida pampeana es en la primera quincena de marzo. La densidad de siembra se debe ajustar según calidad de semilla para obtener 200 plantas m-2 a la emergencia. La fecha de siembra más apropiada para producción de grano es la primera quincena del mes de junio con ciclo emergencia-floración de 114,0±6 días y de 164,0±4 días a madurez de cosecha, dependiendo del año. El Peso promedio de 1000 granos es 33,8 g y el Peso Hectolítrico = 65,6 kg\/hL. el grano es apto para la alimentación animal y tiene uso potencial en la alimentación humana para la elaboración de productos horneables que no requieran harinas leudantes y como materia prima para usos industriales como bioetanol. Tolerante a la sequía invernal y resistente a heladas durante el período juvenil pero como susceptible en floración. Presenta escasa severidad e incidencia de roya de la hoja y manchas foliares que no comprometen la cantidad y calidad del forraje. No se ha registrado ataque de fitoparásitos ni vuelco o arrebatamiento.","palabras_clave":"TRITICALE|BIOMASA FORRAJERA|CULTIVAR|ALIMENTACIÓN ANIMAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3433,"idioma_id":4,"titulo":"Effect of Arsenite on Nitrosative Stress in Human Breast Cancer Cells and Its Modulation by Flavonoids","resumen":"Arsenic (As) is used in the treatment of leukaemia and breast cancer due to its strong oxidative cytotoxic action. However, it is also cytotoxic to normal cells. One proposed anticancer mechanism induced by As might be nitrosative stress (NS). Hence, it is opined that use of antioxidants such as flavonoids in combination with arsenic might reduce its (As) toxic action on normal cells without interfering with its tumoricidal action. In the present study, we evaluated the antineoplastic potential of As on breast human cancer lines MCF-7 and ZR-75-1 treated with redox-modulating flavonoids, such as quercetin (Q) and silymarin (S). It was noted that, even though both cell lines differed about their oxidative responsiveness, their viability was decreased by NS induction through &#947;-glutamyltranspeptidase inhibition. As triggered NS in MCF-7 and ZR-75-1 cultures, being the formers more sensitive without recovering capacity. ZR-75-1 cells maintained their antioxidant status, whereas MCF-7 ones treated with S, As and As+Q did not. Silymarin did not interfere with the described As bioactivity. In summary, NS represents an important anticancer mechanism of As depending on the redox cellular response that could be differentially modified by dietary antioxidants. Hence, it is worthwhile to consider the use of dietary antioxidants as adjuvants in cancer chemotherapy especially while using As.","palabras_clave":"Cancer|Estrés nitrosativo|flavonoides|arsenico"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3435,"idioma_id":4,"titulo":"'Native isolates of Trichoderma harzianum inducting resistance to Mycosphaerella graminicola, on wheat plants'.","resumen":"Aislamientos nativos de Trichoderma harzianum inducen resistencia a Zymoseptoria triticien plantas de trigo. La Septoriosis del trigo es endémica en las regiones productoras de Argentina,impactando en su rendimiento. Una alternativa de manejo, es el uso de agentes de biocontrol. Sepropuso: determinar la efectividad de los aislamientos de Trichoderma obtenidos a partir de suelos dediferentes localidades de la región triguera argentina, sobre el control de la enfermedad y caracterizarla actividad de la serín proteasa (con capacidad antifúngica) del fluido intercelular de trigo generadapor los mejores aislamientos. Para determinar la capacidad biocontroladora de los 90 aislamientos deTrichoderma, se sembraron semillas recubiertas con cada uno de los antagonistas y posteriormentelas plántulas se inocularon con Zymoseptoria tritici. Se evaluó la capacidad de cada aislamiento delbiocontrolador para restringir el progreso de la septoriosis 21 días después de la inoculación. A lasplantas tratadas con las 10 mejores cepas de T. harzianum, se les midió el incremento de la actividadproteolítica. Cuatro de los aislamientos (2 y 8, de Los Hornos y 129 y 141 de Manfredi) disminuyeronel porcentaje de cobertura picnidial y se destacaron por el aumento de la actividad proteolítica en uncultivar susceptible. Éste comportamiento se asocia a un mecanismo bioquímico de defensa con unefecto sistémico temprano.Palabras clave: Trichoderma harzianum, biocontrol, trigo, Septoriosis, RSI, serín proteasa","palabras_clave":"TRICHODERMA HARZIANUM|BIOCONTROL|TRIGO|SEPTORIOSIS|RSI|SERINPROTEASA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3522,"idioma_id":4,"titulo":"Hyaluronan Itaconic Acid Glutaraldehyde Films for Biomedical Applications: Preliminary Studies","resumen":"New hyaluronic acid?itaconic acid films were synthesized as potential materialswith biomedical applications. In this work, we explored the homogeneous crosslinkingreactions of hyaluronic acid using glutaraldehyde in the presence ofitaconic acid and triacetin as plasticizers.Biomechanical properties were assessed in terms of stability by measuringswelling in aqueous environments, investigating wettability using contact angletests and evaluating bioadhesive performance. The ductility of the materialswas evaluated through stress-strain measurements and the morphology wasexplored by scanning electron microscopy.The results show that the incorporation of itaconic acid improved most of thedesirable properties, increasing adhesiveness and reducing wettability andswelling. The use of triacetin enhanced the strength, bioadhesiveness andductility of the materia","palabras_clave":"Hyaluronan|Crosslinked|Biomaterials|Films"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3523,"idioma_id":4,"titulo":"Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study","resumen":"Endothelin-1 (ET-1) and its type A receptor (EDNRA) are vasoconstrictive agents that are involved in hypertension development. There are different works that shows an association between certain polymorphisms of endothelin axis and clinical phenotype of hypertension. We describe the genetic variability +138\/ex1 insertion\/deletion (I\/D) adenosine (A) in the ET-1 gene and polymorphism thymidine\/cytosine (T\/C) His323His in the EDNRA gene associated at the clinical variability in hypertensive patients.Signed a consent to participate in the study 136 patients. From each were assessed serum lipid profiles, renal and hepatic functions and were taken Thoracic X-rays, electrocardiograms, and echocardiographs. DNA extracted from circulating leukocyte were used to analyze the polymorphisms of genes by PCR-RFLP. For the T\/C His323His polymorphism in the EDNRA gene, the CC genotype was less frequent in males (p < 0.02). For both genders, the CC genotype was associated to low plasma alkaline phosphatase activity and cholesterol levels. The T allele correlated with the degree of cardiovascular compromise (r = 0.54, p < 0.002). For the 138ex1 I\/D A polymorphism in the ET-1 gene, the D\/D genotype was associated to normal plasma levels of glutamate\/pyruvate transaminase enzyme activity, uric acid concentration, cholesterol, and LDL in hypertensive subjects without clinical risk. We observed a gender-specific protective effect for EDNRA gene variations, the subjects that carried the TT genotype presented more aggressive symptomatology. These results show an association between plasmatic biochemical parameters, the clinical condition, and polymorphisms in the endothelin axis genes","palabras_clave":"endothelin-1 gene|receptor A gene|genetic variation|hypertension"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3525,"idioma_id":4,"titulo":"Electrochemical formation and characterization of Au nanostructures on a highly ordered pyrolytic graphite surface","resumen":"The electrochemical formation of Au nanoparticles on a highly ordered pyrolytic graphite (HOPG)substrate using conventional electrochemical techniques and ex-situ AFM is reported. From the poten-tiostatic current transients studies, the Au electrodeposition process on HOPG surfaces was described,within the potential range considered, by a model involving instantaneous nucleation and diffusion con-trolled 3D growth, which was corroborated by the microscopic analysis. Initially, three-dimensional (3D)hemispherical nanoparticles distributed on surface defects (step edges) of the substrate were observed,with increasing particle size at more negative potentials. The double potential pulse technique allowedthe formation of rounded deposits at low deposition potentials, which tend to form lines of nuclei alignedin defined directions leading to 3D ordered structures. By choosing suitable nucleation and growth pulses,one-dimensional (1D) deposits were possible, preferentially located on step edges of the HOPG substrate.Quantum-mechanical calculations confirmed the tendency of Au atoms to join selectively on surfacedefects, such as the HOPG step edges, at the early stages of Au electrodeposition.The electrochemical formation of Au nanoparticles on a highly ordered pyrolytic graphite (HOPG)substrate using conventional electrochemical techniques and ex-situ AFM is reported. From the poten-tiostatic current transients studies, the Au electrodeposition process on HOPG surfaces was described,within the potential range considered, by a model involving instantaneous nucleation and diffusion con-trolled 3D growth, which was corroborated by the microscopic analysis. Initially, three-dimensional (3D)hemispherical nanoparticles distributed on surface defects (step edges) of the substrate were observed,with increasing particle size at more negative potentials. The double potential pulse technique allowedthe formation of rounded deposits at low deposition potentials, which tend to form lines of nuclei alignedin defined directions leading to 3D ordered structures. By choosing suitable nucleation and growth pulses,one-dimensional (1D) deposits were possible, preferentially located on step edges of the HOPG substrate.Quantum-mechanical calculations confirmed the tendency of Au atoms to join selectively on surfacedefects, such as the HOPG step edges, at the early stages of Au electrodeposition.","palabras_clave":"HOPG|GOLD|DOUBLE POTENTIAL PULSE TECHNIQUE |DFT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3526,"idioma_id":5,"titulo":"Caracterización morfológica y molecular de una colección de aislamientos  de  Phomopsis longicolla  (teleomorfo desconocido:  Diaporthales )  de la región templada y subtropical de Argentina","resumen":"Phomopsis is a hemi biotrophic fungus that uses many sources of inoculum such as  stubble and seeds to reboot the alternate phases of parasitism ? saprophytism  during its biological cycle. The plasticity of this fungal genus has promoted  its wide expansion to different agro-ecosystems and range of hosts as crop  species and native trees, generating a great epidemiological risk. The  objective was to validate the identity and to evaluate the biological  relationships among 12 isolates of P.  longicolla and Diaporthe phaseolorum  var. sojae (anamorph P. phaseoli var. sojae) obtained in different tempered and subtropical  agro-environments of Argentina, with the aim of analyzing the variability and  to apply the most appropriated strategies for preserving the fungal  biodiversity. Macro-morphological attributes (such as colony texture and color,  stroma shape and distribution, pycnidia and perythecia shape and distribution)  and micro-morphological characteristics (such as conidia, asci, ascospores size  and shape) allowed identifying 3 new isolates as P. longicolla. A complementary molecular analysis was also made to  overcome the limitations derived of the morphological analysis, and  consequently the AFP.8413 isolate was recognized as P. longicolla. Hence, molecular characterization was useful to  define the identity of the evaluated isolates and grouped them in the four taxa  of the Diaporthe\/Phomopsis complex: ten isolates were included in P. longicolla, one isolate was included  in D. phaseolorum var. sojae (anamorph P. phaseoli var. sojae),  one isolate was included in D.  phaseolorum var. caulivora and  two isolates were included in D. phaseolorum  var. meridionalis. In concluding, the  adequate preservation of P. longicolla  biodiversity was promoted based on an appropriated identification and a robust  knowledge of those biological strategies (homo or heterothallic hybridization)  related to mechanism of fungal genetic variability and plasticity to colonize a  broad host range.","palabras_clave":"HEMI-BIOTROPHIC FUNGUS|EPIDEMIOLOGY|CLUSTER ANALYSIS|AGRO-BIOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3527,"idioma_id":4,"titulo":"HER2 and &#946;-catenin protein location: importance in the prognosis of breast cancer patients and their correlation when breast cancer cells suffer stressful situations","resumen":"In human breast cancer, &#946;-catenin localization has been related with disease prognosis. Since HER2-positive patients are an important subgroup, and that in breast cancer cells a direct interaction of &#946;-catenin\/HER2 has been reported, in the present study we have explored whether &#946;-catenin location is related with the disease survival. The study was performed in a tumor bank from patients (n = 140) that did not receive specific anti-HER2 therapy. The proteins were detected by immunohistochemistry in serial sections, 47 (33.5%) patients were HER2-positive with a long follow-up. HER2-positive patients that displayed &#946;-catenin at the plasma membrane (completely surrounding the tumour cells) showed a significant better disease-free survival and overall survival than the patients showing the protein on other locations. Then we explored the dynamics of the co-expression of &#946;-catenin and HER2 in human MCF-7 and SKBR3 cells exposed to different stressful situations. In untreated conditions MCF-7 and SKBR3 cells showed very different &#946;-catenin localization. In MCF-7 cells, cadmium administration caused a striking change in &#946;-catenin localization driving it from plasma membrane to cytoplasmic and perinuclear areas and HER2 showed a similar localization patterns. The changes induced by cadmium were compared with heat shock, H2O2 and tamoxifen treatments. In conclusion, this study shows the dynamical associations of HER2 and &#946;-catenin and their changes in subcellular localizations driven by stressful situations. In addition, we report for the first time the correlation between plasma membrane associated &#946;-catenin in HER2-positive breast cancer and survival outcome, and the importance of the protein localization in breast cancer samples.","palabras_clave":"B-CATENIN|CANCER|INFLAMMATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3528,"idioma_id":4,"titulo":"Phenotype-genotype correlations in haemophilia A carriers are consistent with the binary role of the phase between F8 and X-chromosome inactivation","resumen":"Summary. Background: The recessive X-linked disorder hemophilia A (HA) is rarely expressed in female carriers,most of whom express about half of normal factor VIII activity (FVIII:C). Objective: To propose an integrative assessment model for the binary role of the phase between the mutated F8 and the active X-chromosome (Xa) in FVIII:C in HA carriers. Methods: We studied 67 females at risk of severe HA, comprising five symptomatic females (FVIII:C < 1.5 IU dL1) and 14 controls. A correlation study between FVIII:C (observed vs. expected)  and X-chromosome inactivation (XCI) patterns (XIPs; androgen receptor gene [AR] system) in blood leukocyte DNA was performed in carriers, by comparison of a  model correlating FVIII:C and XIP with arbitrary models devoid of biological significance, and with FVIII:C levels in non-carriers (mean model) as a proxy from background data dispersion not influenced by XIP. Results: We provide proof-of-concept example from a family presenting with extremely skewed XIPs in which the severe HA phenotype appeared in a heterozygous carrier of a crossover between AR and F8 loci that phased the mutated F8 with the maternally inherited Xa. Furthermore, four cases of severe HA affected women who had a combination of a heterozygous F8 mutation and extremely skewed XIPs in leukocytes or oral mucosa are presented. Correlation analyses between FVIII:C levels and XIPs in carriers (n = 38) but not in non-carriers (n = 20) showed highly significant differences between the proposed correlation model and models without biological  significance. The data support a binary influence of XCI, either increasing or decreasing the FVIII:C, subject to the underlying phase set between the F8 mutation and XCI. Conclusions: Our evidence suggests that the phase between XCI and mutated F8 acts as a molecular switch conditioning FVIII:C levels and HA expression in carriers.","palabras_clave":"F8 protein |hemophilia A|X-linked genetic diseases|X chromosome inactivation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3529,"idioma_id":4,"titulo":"Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions","resumen":"AbstractPharmacokinetic profile, tissue concentrations and urine elimination of cephalothin incats under surgical conditions after a single intravenous dose (30 mg\/kg) were studied.Initial plasma concentrations were high (Cp(0), 353.79±118.92 &#956;g\/mL), with fast andmoderately wide distribution (T½(d) 0.14±0.10 h) (V(d(ss)) 0.19±0.03 L\/kg) and rapidelimination (ClB, 0.16±0.03 L\/h.kg; T½, 1.07±0.23 h; MRT, 1.16±0.21 h).Thirty to 60 minutes after intravenous administration, cephalothin tissue concentrationswere in the range of 3.73 &#956;g\/g (testicle tissue) to 25.63 &#956;g\/g (uterus). Tissue\/plasmaconcentrations rate was in a range of 0.04 (testicle) to 0.21 (uterus). Cephalothin urineelimination was 66.49% in the first 6 hours after administration.Cephalothin plasma concentrations remained above a MIC&#8805;1&#956;g\/mL up to 5.5 hours inall the studied cats. However, for MIC&#8805;8&#956;g\/mL (MIC breakpoint) this time is reducedto 2.5 hours. This suggests that proper perioperative prophylactic use of cephalothin incats requires a dose interval not longer than 2 hours.","palabras_clave":"PHARMACOKINETICS|CEPHALOTIN|CATS|SURGERY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3530,"idioma_id":4,"titulo":"Corticosterone Plasma Levels of Embryos and Newly Hatched Broad-snouted Caiman (Caiman latirostris) Incubated at Different Temperatures","resumen":"The temperature-sensitive period is the time during development during which sex determination occurs in vertebrates that undergo temperature-dependent sex determination, such as in caimans. The interplay among temperature and steroid hormones is also known, and it has been suggested that stress hormones (corticosterone) might influence sex ratios in some reptiles. To explore this, we measured the levels of corticosterone in Caiman latirostris to determine if incubation temperature (31°C, 33°C, and 34°C) affects plasma corticosterone levels. Differences among nests were observed in plasma corticosterone. However, hormone levels showed no significant differences between sexes or incubation temperatures in Caiman latirostris embryos or hatchlings. Corticosterone levels were 0.01?2.2 ng\/ mL in embryos incubated at 31°C (100% of females), 0.01?4.65 ng\/mL in those incubated at 33°C (100% of males), and 0.01?6.31 ng\/mL in embryos incubated at 34°C (100% of males). Corticosterone levels were higher in hatchlings, being 1.11?39.18 in those produced at 31°C, 2.85?22.36 at 33°C, and 2.72?39.05 ng\/mL at 34°C.","palabras_clave":"Crocodilians|Hormones|Temperature-dependent sex determination|Temperature-sensitive period"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3531,"idioma_id":4,"titulo":"Synthesis of Ni Nanoparticles by Femtosecond Laser Ablation in Liquids: Structure and Sizing","resumen":"Synthesis of nickel (Ni) nanoparticles (NPs) suspensions was performed using a 120 femtosecond (fs) pulse laser to ablate a Ni solid target in n-heptane and water. Analysis of structure, configuration and sizing was carried out using different independent techniques such as Optical Extinction Spectroscopy (OES), Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM) and Electron Diffraction (ED), which yield interrelated information.  AFM microscopy allows determining the spherical shape and size distribution of the NPs in the obtained colloids while TEM provides knowledge about shape, structure and size distribution. ED allows identification of the different metal and metal oxide composition as well as their crystallographic phase. On the other hand, OES gives information related to size distribution, structure, configuration and composition. Interpretation of these spectra is based on Mie theory which, in turn, depends on Ni dielectric function. For NPs radii smaller than 3 nm, size-dependent free and bound electron contributions to the dielectric function must be considered. To account for the full size span, complete Mie expansion was used for optical extinction cross-section calculations. A theoretical analysis of the dependence of plasmon resonance of bare core and core-shell Ni NPs with core size and shell thickness provide insight about their spectroscopic features.  For n-heptane, species like bare core Ni and hollow Ni NPs are found in the colloid, being the latter reported for the first time in this work. Instead, for water, the colloid contains hollow nickel NPs and nickel oxide in different core-shell configurations: Ni-NiO and NiO-Ni, being the latter also reported for the first time in this paper. In both cases, size distribution agrees with that derived from TEM and AFM analysis. The formation of the oxide species is discussed in terms of oxidation-reduction processes during ablation. Possible mechanisms for the formation of hollow species are proposed.","palabras_clave":"nickel nanoparticles|laser ablation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3532,"idioma_id":4,"titulo":"Effect of the interaction between Anticarsia gemmatalis multiple nucleopolyhedrovirus and Epinotia aporema granulovirus, on A. gemmatalis (Lepidoptera: Noctuidae) larvae","resumen":"The bean shoot borer Epinotia aporema Wals. (Lepidoptera:  Tortricidae) and the velvet bean caterpillar Anticarsia gemmatalis Hübner (Lepidoptera: Noctuidae) are key pests  of soybean and other legume crops in South America.  They are often found simultaneously in certain regions. A. gemmatalis  nucleopolyhedrovirus (AgMNPV) is widely used to control A. gemmatalis. More recently, E. aporema granulovirus (EpapGV) has been characterized and evaluated as a  bioinsecticide for E. aporema. In order to increase its potential use and to design optimized strategies for the  management of lepidopteran pests, we evaluated the interaction between EpapGV  and AgMNPV on third instar A. gemmatalis larvae. Larvae fed with 50  AgMNPV OBs\/larva showed an increase in the mortality rates (from 42% to 81%) and  a decrease in the median survival time (from 7.7 days to 5.7 days) when these OBs were mixed with 6000 EpapGV  OBs\/larva. When 300 AgMNPV OBs\/larva were used alone or in combination with  EpapGV OBs no changes in biological parameters were observed. No mortality was  detected in A. gemmatalis larvae treated  with EpapGV alone. In larvae fed with the  viral mixtures, only AgMNPV DNA was detected by PCR. A. gemmatalis peritrophic membranes (PMs) examined by SDS-PAGE and  scanning electron microscopy showed signs of damage. Notably, we found the  presence of spheroidal bodies associated with damaged areas in the PMs of  larvae fed with EpapGV but not in those that were given AgMNPV alone. These  results show that EpapGV increases the viral potency of AgMNPV, and thus the  insecticidal efficiency, suggesting that the use of formulations including both  viruses might be a valuable tool for pest management","palabras_clave":"BACULOVIRUS|ANTICARSIA GEMMATALIS NUCLEOPOLYHEDROVIRUS|EPINOTIA APOREMA GRANULOVIRUS|PERITROPHIC MEMBRANE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3533,"idioma_id":4,"titulo":"Apoptosis and cell proliferation in the mouse model of embryonic death induced by Tritrichomonas foetus infection","resumen":"Bovine tritrichomonosis is a sexually transmitted disease caused by the protozoon Tritrichomonas foetus and characterised by embryonic-death and abortion. During pregnancy theprocesses of cell proliferation and death play a crucial role for blastocyst implantation and the subsequent maintenance of early pregnancy, and their misbalance may lead to the abortion. In this study we aimed to investigate whether cell proliferation and death may be altered during tritrichomonosis. For this purpose, we used pregnant BALB\/c mice as an alternative experimental animal model that has successfully reproduced the infection. We analysed the immunohistochemical expression of active caspase-3 and proliferating cell nuclear (PCNA) antigens in the endometrium of infected mice. We found an increase in the number of caspase-3 positive cells in infected mice that were not pregnant at the necropsy. Besides, the number of positive proliferating cells increased in the uterine luminal epithelium of infected animals killed at 5-7 days post coitum (dpc). Pregnant infected mice killed at 8-11 dpc showed higher proliferation than control animals. We suggest that the cytopathic effect induced by T. foetus in the uteri of infected mice may induce the apoptosis of the epithelial cells and, as a result, promote a compensatory proliferative response. The information here described will be helpful to further study the pathogenesis of the bovine tritrichomonosis. ","palabras_clave":"BOVINE TRITRICHOMONOSIS|MOUSE MODEL|CELL PROLIFERATION|APOPTOSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3534,"idioma_id":4,"titulo":"Previous failure of interferon-based therapy does not alter the frequency of HCV NS3 protease or NS5B polymerase inhibitor resistance-associated variants: longitudinal analysis in HCV\/HIV co-infected patients.","resumen":"Background.  Since 2011 treatment of chronic HCV includes direct antiviral agents (DAA) in addition to pegylated interferon-&#945; and ribavirin (peg-IFN+RBV). IFN-based treatment induces a strong cytotoxic T lymphocyte activity directed to the protease and polymerase-derived epitopes. This enhanced immunological pressure could favor the emergence of viral epitope variants able to evade immune surveillance and when RAVs are implied, could also be co-selected as a hitchhiking effect. Objective. To analyze the dynamics of the frequency of protease and polymerase inhibitors RAVs that could affect future HCV treatment in HIV-coinfected patients on stable antiretroviral therapy with previous IFN-based treatment failure.Methods. HCV genotype 1a RNA was extracted from plasma samples of 18 patients previous and during (24h, and 4, 12, 24, and 48 weeks) peg-IFN+RBV therapy. Next-generation sequencing (454 FLX, Roche) was performed on HCV RNA populations using NS3 and NS5B PCR-amplified coding region. Two measures of genetic diversity were used to compare virus populations: average pairwise nucleotide diversity (&#960;) and Tajima?s D statistic. Results. Several protease and polymerase RAVs were detected in all subjects at very low frequencies (<5%) and in most cases their presence was not constant during the follow-up. Only samples from two patients for each region exhibited Q80R\/K\/L and A421V as highly predominant variants. No significant differences were observed among sampling times neither for &#960; nor for D values.Conclusions. Previous therapy and failure to peg-IFN+RBV were not associated with the increase in DAA targeting NS3 or NS5B RAVs that naturally exist, in HIV-coinfected subjects.","palabras_clave":"Direct-acting antivirals|HCV|NS3|NS5B|Peg-IFN|Resistance-associated variants (RAVs)"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3535,"idioma_id":4,"titulo":"Genotyping and study of the pauA and sua genes of Streptococcus uberis isolates from bovine mastitis","resumen":"This study aimed to determine the clonal relationship among 137 Streptococcus uberis isolates from bovine milk with subclinical or clinical mastitis in Argentina and to assess the prevalence and conservation of pauA and sua genes. This information is critical for the rational design of a vaccine for the prevention of bovine mastitis caused by S. uberis. The isolates were typed by random amplified polymorphic DNA (RAPD) analysis and by pulsed-field gel electrophoresis (PFGE). The 137 isolates exhibited 61 different PFGE types and 25 distinct RAPD profiles. Simpson's diversity index was calculated both for PFGE (0.983) and for RAPD (0.941), showing a high discriminatory power in both techniques. The analysis of the relationship between pairs of isolates showed 92.6% concordance between both techniques indicating that any given pair of isolates distinguished by one method tended to be distinguished by the other. The prevalence of the sua and pauA genes was 97.8% (134\/137) and 94.9% (130\/137), respectively. Nucleotide and amino acid sequences of the sua and pauA genes from 20 S. uberis selected isolates, based on their PFGE and RAPD types and geographical origin, showed an identity between 95% and 100% with respect to all reference sequences registered in GenBank. These results demonstrate that, in spite of S. uberis clonal diversity, the sua and pauA genes are prevalent and highly conserved, showing their importance to be included in future vaccine studies to prevent S. uberis bovine mastitis.","palabras_clave":"Bovine mastitis |Molecular typing|Streptococcus uberis|PauA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3537,"idioma_id":4,"titulo":"A polymer chip-integrable piezoelectric micropump with low backpressure dependence","resumen":"We describe a piezoelectric micropump constructed in polymers with conventional machining methods. The micropump is self-contained and can be built as an independent device or as an on-chip module within laminated microfluidic chips. We demonstrate on-chip integrability by the fabrication and testing of an active micromixer with&nbsp;two pumps. Average flow rates from sub-ul min-1 to 300 ul min-1 can&nbsp;be obtained with low influence from the backpressure up to approximately 10 kPa. The micropump design allows potential use in low-cost disposable polymeric Lab on a Chip devices.","palabras_clave":"Chip-integrable|Micropump|Polymer|Low backpressure dependence"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3538,"idioma_id":5,"titulo":"Primer registro de Triatoma infestans (Klug) (Hemiptera: Reduviidae) asociado a nidos de loros barranqueros (Cyanoliseus patagonus) (Aves: Psittacidae)","resumen":"Triatoma infestans es el vector más importante de la enfermedad de Chagas de la Argentina. Se cita por primera vez la presencia de T. infestans (Klug) (Hemiptera: Reduviidae) asociado a nidos de loro barranquero Cyanoliseus patagonus (Psittasiformes: Psittacidae) construidos en viviendas de adobe abandonadas. Se discuten las posibles implicancias de este hallazgo para la vigilancia entomológica del vector.","palabras_clave":"Triatominos|Vinchucas|Enfermedad de Chagas|Loros"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3544,"idioma_id":5,"titulo":"Una perspectiva arqueológica de los modos del comer en el predio mercedario de Mendoza","resumen":"En este trabajo se presentan las interpretaciones realizadas sobre los objetos y modos del comer durante los períodos indígenas, coloniales y republicanos en la ciudad de Mendoza, aplicando los criterios elaborados por Lull (2007). Las interpretaciones se aplican al registro arqueológico proveniente de las ruinas de la iglesia de La Merced (Chiavazza y Zorrilla, 2005). La intención de este trabajo es la de contribuir al conocimiento de las prácticas alimentarias y cómo los objetos del comer modelan y reproducen la lógica social de distribución de los recursos correspondientes a los contextos indígenas, coloniales y republicanos en la Ciudad de Mendoza.","palabras_clave":"ARQUEOLOGÍA HISTÓRICA MENDOZA|OBJETOS DEL COMER|PREDIO MERCEDARIO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3878,"idioma_id":4,"titulo":". Acute and chronic toxicity of glyphosate to native fish from San Luis province, Argentina.","resumen":"Public concern on the risks of glyphosate exposure has risen in Argentina, where glyphosate is used massively. Fish are widely used as models to assess the effects of contaminants. In this study we estimated the toxic effects of glyphosate (Roundup) on Cheirodon interruptus, Australoheros facetus and Jenynsia multidentata, three native fish species from San Luis, Argentina. Adult mortality was registered after acute exposure to Roundup (0 to 100 &#956;L\/L). The minimum concentration causing 100% mortality (MC100%M) and the maximum concentration with no mortality detected (MC0%M) were recorded. Biomarkers (hepatic enzymes and acetylcholinesterase) were assessed in fish that where chronically exposed to a sublethal concentration of Roundup. Inter-specific differences in sensitivity were not detected. The MC100%M was 50 &#956;L\/L and the MC0%M was 25 &#956;L\/L for the three species. Exposed fish had significantly higher hepatic enzymes and significantly reduced acetylcholinesterase activity levels compared to controls. This study provides valuable evidence on the impacts of glyphosate on native fish species.","palabras_clave":"ROUNDUP|NATIVE FISH|TOXIC EFFECTS|MORTALITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3879,"idioma_id":4,"titulo":"Arbuscular mycorrhizal symbiosis regulates physiology and performance of Digitaria eriantha plants subjected to abiotic stresses by modulating antioxidant and jasmonate levels","resumen":"Abstract This study evaluates antioxidant responses andjasmonate regulation in Digitaria eriantha cv. Sudafricanaplants inoculated (AM) and non-inoculated (non-AM) withRhizophagus irregularis and subjected to drought, cold, orsalinity. Stomatal conductance, photosynthetic efficiency, biomassproduction, hydrogen peroxide accumulation, lipid peroxidation,antioxidants enzymes activities, and jasmonatelevels were determined. Stomatal conductance and photosyntheticefficiency decreased in AM and non-AM plants underall stress conditions. However, AM plants subjected todrought, salinity, or non-stress conditions showed significantlyhigher stomatal conductance values. AM plants subjectedto drought or non-stress conditions increased their shoot\/rootbiomass ratios, whereas salinity and cold caused a decrease inthese ratios. Hydrogen peroxide accumulation, which washigh in non-AM plant roots under all treatments, increasedsignificantly in non-AM plant shoots under cold stress andin AM plants under non-stress and drought conditions. Lipidperoxidation increased in the roots of all plants under droughtconditions. In shoots, although lipid peroxidation decreased in AM plants under non-stress and cold conditions, it increasedunder drought and salinity. AM plants consistently showedhigh catalase (CAT) and ascorbate peroxidase (APX) activityunder all treatments. By contrast, the glutathione reductase(GR) and superoxide dismutase (SOD) activity of AM rootswas lower than that of non-AMplants and increased in shoots.The endogenous levels of cis-12-oxophytodienoc acid(OPDA), jasmonic acid (JA), and 12-OH-JA showed a significantincrease in AM plants as compared to non-AM plants.11-OH-JA content only increased in AM plants subjected todrought. Results show that D. eriantha is sensitive to drought,salinity, and cold stresses and that inoculation with AM fungiregulates its physiology and performance under such conditions,with antioxidants and jasmonates being involved in thisprocess.Keywords Arbuscular mycorrhiza . Cold stress . Digitariaeriantha . Drought stress . Jasmonates . Salt stress","palabras_clave":"ARBUSCULAR MYCORRHIZA|COLD STRESS|DIGITARIA ERIANTHA|DROUGHT STRESS|JASMONATES|SALT STRESS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3880,"idioma_id":5,"titulo":"COMPOSICIÓN NUTRICIONAL DE FRUTOS DE SYAGRUS ROMANZOFFIANA (PINDÓ) NATIVOS DE FORMOSA- ARGENTINA","resumen":"La palmera ?pindó? (Syagrus romanzoffi ana) es una especie nativa,abundante en la provincia de Formosa, Argentina. Las plantas producenfrutos con formas diferentes, ovalados y esféricos. Se determinóel perfi l de ácidos grasos (AG) en los frutos enteros y antioxidantesy proteínas en pulpa seca molida. Se indagó si las diferentesformas implican variación en la composición nutricional y en antioxidantes.Los datos experimentales arrojaron diferencias en el perfi lde ácidos grasos según la forma. Los frutos esféricos, muestran unarelación entre ácidos grasos, saturados e insaturados, benefi ciosapara la salud humana, con un perfi l intermedio entre el aceite deoliva y girasol. Las proteínas en frutos ovalados fue de 3,57 g\/100g y 3,66 g\/100 g en esféricos. Entre los antioxidantes, la vitaminaC presenta valores con diferencia signifi cativa entre los frutos ovaladosy esféricos, conteniendo estos últimos mayor concentración,5,23 mg\/g. Se encontraron diferencias signifi cativas en compuestosfenólicos según la forma de los frutos, 7,53 mgEAG\/100 g para losesféricos. La determinación de carotenoides totales fue de 160,64en ovalados y 213,56 &#956;g &#946;-caroteno\/g en esféricos. El perfi l de AGde frutos esféricos y la proporción de aceites encontrada, los convierteen un producto apto para la extracción de aceites comestiblesbenefi cioso para la salud dada su proporción de AG saturados\/insaturados,(1\/2,5) utilizando el fruto entero. El alto contenido de compuestosbioactivos, polifenoles, carotenoides y vitamina C realza lacalidad nutricional de la pulpa de éstos frutos y su potencial uso paraenriquecimiento de diferentes productos alimenticios.","palabras_clave":"pindó|palmera|composición nutricional|antioxidantes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":3911,"idioma_id":4,"titulo":"The potential application of plant essential oils to control Pediculus humanus capitis (Anoplura: Pediculidae","resumen":"The human head louse, Pediculus humanus capitis(Anoplura: Pediculidae), is an ectoparasite confined to the scalpand human hairs. The repeated use of insecticides for the controlof head lice during past decades has resulted in the developmentof marked levels of resistance. Natural compounds such as essentialoils (EOs) have been suggested as alternative sources forinsect control agents. In order to introduce a new pediculicidebased on EOs, the effectiveness of the product and their effectson human being must be analyzed. In consequence, the biologicalactivity of EOs from the leaves and fruits of Schinus areira(Anacardiaceae) and the leaves of Thymus vulgaris(Lamiaceae), Aloysia polystachya and Aloysia citriodora(Verbenacea) were evaluated against the eggs and adults ofP. humanus capitis by fumigant and contact toxicity bioassays.Additionally, dermal corrosion\/irritation tests were performedon New Zealand albino rabbits. In a fumigant bioassay, EOsfrom the leaves and fruits of S. areira were the most toxicagainst P. humanus capitis adults while these EOs andT. vulgaris were the most effective against the eggs. In contactbioassay, the EO from T. vulgaris was the most toxic againstboth stages. In the corrosion\/irritation tests, the EOs did notproduce dermal effects. According to the results, the essentialoils from the leaves of T. vulgaris would be a valid tool for themanagement of P. humanus capitis. This EO produces a highknockdown effect in adults (followed by mortality) and toxicityin the eggs when it is applied for 21 min at a low concentration.","palabras_clave":"HEAD LICE|ESSENTIAL OILS|ADULTICIDAL|OVICIDAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":4120,"idioma_id":4,"titulo":"An update on cell surface proteins containing extensin-motifs","resumen":"In recent years it has become clear that there are several molecular links that interconnect the plant cell surface continuum, which is highly important in many biological processes such as plant growth, development, and interaction with the environment. The plant cell surface continuum can be defined as the space that contains and interlinks the cell wall, plasma membrane and cytoskeleton compartments. In this review, we provide an updated view of cell surface proteins that include modular domains with an extensin (EXT)-motif followed by a cytoplasmic kinase-like domain, known as PERKs (for proline-rich extensin-like receptor kinases); with an EXT-motif and an actin binding domain, known as formins; and with extracellular hybrid-EXTs. We focus our attention on the EXT-motifs with the short sequence Ser-Pro(3?5), which is found in several different protein contexts within the same extracellular space, highlighting a putative conserved structural and functional role. A closer understanding of the dynamic regulation of plant cell surface continuum and its relationship with the downstream signalling cascade is a crucial forthcoming challenge.","palabras_clave":"PARED CELULAR|polen|pelo radicular"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":4128,"idioma_id":4,"titulo":"Structural study of a flexible active site loop in human indoleamine 2,3-dioxygenase and its functional implications","resumen":"Human indoleamine 2,3-dioxygenase catalyses the oxidative cleavage of tryptophan to N-formyl kynurenine,the initial and rate-limiting step in the kynurenine pathway. Additionally, this enzyme has been identified as a possible target for cancer therapy. A 20-amino acid protein segment (the JK loop), which connects the J and K helices, was not resolved in the reported hIDO crystal structure. Previous studies have shown that this loop undergoes structural rearrangement upon substrate binding. In this work, we apply a combination of replica exchange molecular dynamics simulations and site-directed mutagenesis experiments to characterize the structure and dynamics of this protein region. Our simulations show that the JK loop can be divided into two regions: the first region (JK loopC) displays specific and well-defined conformations and is within hydrogen bonding distance of the substrate, while the second region (JK loopN) is highly disordered and exposed to the solvent. The peculiar flexible nature of JK loopN suggests that it may function as a target for post-translational modifications and\/or a mediator for protein&#8722;protein interactions. In contrast, hydrogen bonding interactions are observed between the substrate and Thr379 in the highly conserved ?GTGG? motif of JK loopC, thereby anchoring JK loopC in a closed conformation, which secures the appropriate substrate binding mode for catalysis. Site-directed mutagenesis experiments confirm the key role of this residue, highlighting the importance of the JK loopC conformation in regulating the enzymatic activity. Furthermore, the existence of the partially and totally open conformations in the substrate-free form suggests a role of JK loopC in controlling substrate and product dynamics.","palabras_clave":"IDO|DFT|QM-MM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":4161,"idioma_id":4,"titulo":"Pharmacokinetics of cefuroxime after intravenous, intramuscular and subcutaneous administration to dogs","resumen":"Cefuroxime pharmacokinetic profile was investigated in 6 Beagle dogs after single intravenous, intramuscular and subcutaneous administration at a dose rate of 20 mg\/kg. Blood samples were withdrawn at predetermined times over a 12 hours period. Cefuroxime plasma concentrations were determined by HPLC. Peak plasma concentration (Cmax), time to peak plasma concentration (Tmax) and bioavailability for the intramuscular and subcutaneous administration were 22.99±7.87 µg\/mL, 0.43±0.20 h and 79.70±14.43% and 15.37±3.07 µg\/mL, 0.99±0.10 h and 77.22±21.41%, respectively. Elimination half-lives and mean residence time for the intravenous, intramuscular and subcutaneous administration were 1.12±0.19 h and 1.49±0.21 h; 1.13±0.13 and 1.79±0.24 h; and, 1.04±0.23 h and 2.21±0.23 h, respectively. T>MIC, considering a MIC of 1 µg\/mL was 11 h for intravenous and  intramuscular administration  and 12h for the subcutaneous route. When a MIC of 4 µg\/mL is considered, T>MIC for intramuscular and subcutaneous administration was estimated in 8 h.","palabras_clave":"ANTIMICROBIALS|CEFUROXIME|DOG|PHARMACOKINETICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":4241,"idioma_id":4,"titulo":"Measuring the Impact of Agile Coaching on Students' Performance","resumen":"Abstract--- Nowadays, considerable attention is paid to agile methods as a means to improve management of software development processes. The widespread use of such methods in professional contexts has encouraged their integration into software engineering training and undergraduate courses. Although there are several research works that focus on teaching Scrum through simulating a software development project, they cover only the learning of practices within a Scrum team. Furthermore, few studies tackle non-technical skills beyond the development practices. In this context, an original training model based on Scrum enhanced then with agile coaching to maximize student?s performance is introduced; this model has been validated by a case-study using a capstone project in a Scrum course. This work summarizes the fruitful results after introducing agile coaching, which resulted in approximately 22% more coverage of software engineering practices. Finally, a survey revealed that, in comparison with non-coached students, coached students gained valuable insights about internalization of Scrum, solutions of impediments, and guidance by means of check-point meetings.","palabras_clave":"AGILE COACHING|CAPSTONE PROJECT|SCRUM|SOFTWARE ENGINEERING EDUCATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":4244,"idioma_id":4,"titulo":"Nanostructured CuOx coatings onto Cu foils: Surface growth by the combination of gas-phase treatments","resumen":"In this work, the growth of copper oxide nanoarrays on the surface of copper foils by gas-based oxidation treatments was analyzed, employing either NH3?H2O2 vapors or air at high temperature. By adjusting the treatment conditions, homogeneous and firmly anchored copper oxide coatings were obtained, with densely packed surface nanostructures in the form of nanowires, nanofibers or nanorods. The homogeneity and stability of these nanostructures critically depends on the surface texture of the support, which can be easily changed by sanding or FeCl3 pretreatments. The sequential combination of both treatments allowed modifying the oxidenanoarchitectures and their surface composition. The NH3?H2O2\/air sequence led to a transformation of surface nanorods with an outermost layer of Cu2O, first in CuO nanograins from which then CuO nanowires grew. A reverse combination, air\/NH3?H2O2, generated a dense growth of cobweb-like nanofibers onto a base layer of CuO nanowires. The surface oxide nanostructures obtained, distributed in a large area and firmly anchored to the support, have great potential for the development of structured catalysts.","palabras_clave":"NANOSTRUCTURED SURFACE|COPPER OXIDE|SYNTHESIS|COATING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":4246,"idioma_id":4,"titulo":"Effects of post-suckling n-3 polyunsaturated fatty acids: Prevention of dyslipidemia and liver steatosis induced in rats by a sucrose rich diet during pre and post-natal life","resumen":"The interaction between fetal programming and the post-natal environment suggests that the post-natal diet could amplify or attenuate programmed outcomes. We investigated whether dietary n-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) at weaning resulted in an amelioration of dyslipidemia, adiposity and liver steatosis that was induced by a sucrose-rich diet (SRD; where the fat source is corn oil) from the onset of pregnancy up to adulthood. During pregnancy and lactation, dams were fed an SRD or the standard powdered rodent commercial diet (RD). At weaning and until 150 days of life, male offspring from SRD-dams were divided into two groups and fed an SRD or SRD-with-fish oil [where 6% of the corn oil was partially replaced by fish oil (FO) 5% and corn oil (CO) 1%], forming SRD-SRD or SRD-FO groups. Male offspring from RD-dams continued with RD up to the end of the experimental period, forming an RD-RD group. The presence of FO in the weaning diet showed the following: prevention of hypertriglyceridemia and liver steatosis, together with increased lipogenic enzyme activity caused by a maternal SRD; the complete normalization of CPT I activity and PPAR&#945; protein mass levels; a slight but not statisticallysignificant accretion of visceral adiposity; and limited body fat content and reduced plasma free fatty acid levels. All of these results were observed even in the presence of a high-sucrose diet challenge after weaning. SRD-dams breast milk showed a more saturated fatty acid composition. These results suggest the capacity of n-3 PUFAs to overcome some adverse outcomes induced by a maternal and postweaning sucrose-rich diet.","palabras_clave":"AFTER SUCKING DIET|N-3 POLYUNSATURATED FATTY ACIDS|PRE AND POST-NATAL SUCROSE-RICH DIET|LIPID METABOLISM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":4448,"idioma_id":4,"titulo":"Insulin and leptin signaling in placenta from gestational diabetic subjects","resumen":"Insulin and leptin receptors are known to share signaling pathways, such  as JAK2\/STAT-3 (Janus kinase 2\/signal transduction and activator of  transcription 3), MAPK (Mitogen activated protein kinase) and PI3K  (phosphoinositide 3-kinase). Both positive and negative cross-talk have  been previously found in different cellular systems. Gestational diabetes  (GDM) is a pathophysiological state with high circulating levels of both  insulin and leptin. We have previously found that these three signaling  pathways are activated in placenta from GDM patients to promote  translation, involving the activation of leptin receptor. Now, we tested the  hypothesis that both leptin and insulin receptors might contribute to this  activation in a positive way that may become negative when the system is  overactivated. We studied the activation of leptin and insulin receptors in  placenta from GDM and normal pregnancies. Besides, we performed in  vitro studies with insulin and leptin stimulation of trophoblast explants.  We have found that both leptin and insulin receptors are activated in  placenta from GDM. In vitro stimulation of trophoblast explants with both  leptin and insulin at submaximal doses (0.1nM) potentiated the activation  of signaling, whereas preincubation with maximal concentrations of insulin  (10nM) and further stimulation with leptin showed negative effect.  Similarly, trophoblastic explants from GDM placenta, which presented high  signaling levels, had a negative signaling effect when further incubated in  vitro with leptin.  In conclusion, insulin and leptin receptors have positive effects on  signaling, contributing to high signaling levels in placenta from GDM, but  insulin and leptin have negative effects upon overstimulation.","palabras_clave":"Placenta|Insulin|Leptin|Diabetic"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":4547,"idioma_id":5,"titulo":"Reflexiones sobre Federalismo y Recursos Naturales en el Oeste argentino. Una aproximación desde la Ecología política.","resumen":"El denominado federalismo ha producido encendidos debates e innumerables crisis en la Historia argentina. En el presente artículo se buscará reflexionar sobre algunos puntos en los que se cruza el federalismo y los denominados recursos naturales, desde diferentes categorías de la Ecología política y la Historia ambiental. El primer objetivo es, sin duda, comenzar a pensar categorías superando la tradicional dicotomía Sociedad\/Naturaleza.Categorías clásicas de Economía Política, como desarrollo y democracia son también de sumo interés para este tipo de planteos.","palabras_clave":"ECOLOGIA POLITICA|FEDERALISMO|DEMOCRACIA|DESARROLLO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":4865,"idioma_id":5,"titulo":"CARACTERIZACION DE ASIGNATURAS DEL CICLO BASICO DE LA LICENCIATURA EN BIOLOGIA DE LA FACENA (UNNE), EN FUNCION DEL DESEMPEÑO DE SUS ESTUDIANTES","resumen":" Este trabajo tiene por objetivo caracterizar a las asignaturas del Ciclo Básico de la Licenciatura en Ciencias Biológicas de la Facultad de Ciencias Exactas y Naturales y Agrimensura de la Universidad Nacional del Nordeste, en función del desempeño de sus estudiantes. Se analizaron cuatro variables: 1) probabilidad de aprobar la asignatura, 2) número promedio de intentos para lograrlo, 3) tiempo promedio requerido para aprobar, 4) porcentaje de alumnos a quienes la aprobación les resultó una tarea crítica (porcentaje de criticidad). El mayor número promedio de intentos, y menor probabilidad de aprobar, lo registran Química General, Física, Matemática y Morfología Vegetal, en ese orden, resultando las aprobaciones de Física y Matemática críticas para más del 80% de los casos analizados. Las asignaturas se agruparon mediante análisis cluster en cuatro clases: una formada por asignaturas que presentan elevados porcentajes de criticidad, altos números de intentos y duraciones promedio intermedias; otra formada por las que presentan bajos porcentajes de criticidad, bajos números de intentos y las mayores duraciones promedio; otra que agrupa a asignaturas que presentan bajos porcentajes de criticidad, escasos intentos de aprobación y duraciones promedio muy variables; y finalmente, una clase formada sólo por Química General, que presenta características particulares. ","palabras_clave":"Rendimiento Académico|Distribución Geométrica|Probabilidad de Aprobación|Programación por camino crítico|Análisis de conglomerados"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":4900,"idioma_id":4,"titulo":"Probing behavior of aposymbiotic green peach aphid (Myzus persicae Sulzer) on susceptible Solanum tuberosum and resistant Solanum stoloniferum plants","resumen":"The green peach aphid, Myzus persicae Sulzer (Hemiptera: Aphididae) is one of the potato important pests; it is the most efficient vector of potato viruses. Myzus persicae harbors the endosymbiotic bacteria Buchnera aphidicola which supplements their diet. There is increasing evidence that B. aphidicola is involved in plant-aphid interactions and we previously demonstrated that B. aphidicola disruption (aposymbiosis) affected the probing behavior of M. persicae on radish plants, delaying host plant acceptance. In this work, we evaluated the effect of aposymbiosis on the probing behavior of M. persicae on two Solanum species with different compatibility with M. persicae, Solanum tuberosum (susceptible) and Solanum stoloniferum (resistant) with the electrical penetration graph technique (EPG). To disrupt B. aphidicola, rifampicin was administered to aphids through artificial diets. Aposymbiotic aphids, on both plant species, showed increased pathway activities, mechanical problems with the stylets, and delayed salivation in the phloem. The extended time in derailed stylet mechanics affects the occurrence of most other probing activities; it delayed the time to the first phloem phase and prevented ingestion from the phloem. The effect of aposymbiosis was more evident in the compatible interaction of M. persicae - S. tuberosum, than in the incompatible interaction with S. stoloniferum which generated the M. persicae-S. tuberosum interaction to become incompatible. These results confirm that B. aphidicola is involved in the plant-aphid interaction in relation to plant acceptance, presumably through a role in stylets penetration in the plant.","palabras_clave":"APHID|ARTIFICIAL DIETS|BUCHNERA APHIDICOLA|EPG TECHNIQUE|POTATO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":5040,"idioma_id":4,"titulo":"Can achene selection in sunflower crop-wild hybrids by pre-dispersal seed predators hasten the return to phenotypically wild sunflowers?","resumen":"Bird attack is a serious limitation to sunflower yield in several regions of the world, but it could also cause selection. The wild Helianthus annuus, naturalized in several regions of the world, hybridizes with the crop and produces crop?wild offspring. It is unknown how the selective force of seed predation by birds could drive evolution after a hybridization event. After two generations of natural selection exerted by birds (mostly by Eared Dove and Monk Parakeets), achene and plant traits of the crop?wild hybrid progeny were compared with the same hybrid progeny without any selection by birds. After two generations of bird selection the achene width, thickness and weight decreased by an average of 18.5, 26.7 and 49.2 %, respectively. Also in response to bird selection there was a correlated increase in the plant height, stem diameter, number of heads and a reduction in head diameter and the number of achenes per head. The phenotype of crop?wild plants selected by birds resembles wild plants, whereas the plants without any selection were intermediate between the parents. These results indicate that selection exerted by birds could result in the rapid evolution of crop?wild sunflower populations. © 2015, Springer Science+Business Media Dordrecht.","palabras_clave":"Bird selection|Achene|Phenotype|Wild sunflower"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":5228,"idioma_id":4,"titulo":"Dense mullite- zirconia- zirconium titanate ceramic composites by reaction sintering","resumen":"AbstractMaterials from the Al2O3?SiO2?ZrO2 and the Al2O3?SiO2?ZrO2?TiO2 systems have several high temperature applications because theypresent the good refractoriness, chemical inertness, adequate mechanical and thermo-mechanical behaviors with a relatively good cost:performance ratio. In this work stoichiometric (3:2:1) molar incompatible mixtures of alumina (Al2O3), zircon (ZrSiO4) and titania (TiO2) wereslip casted and sintered in a 1300?1500 1C temperature range in order to obtain mullite (3Al2O3  2SiO2), zirconia (ZrO2) and zirconium titanate(ZrTiO4) dense triple ceramic composite.Both sintering and reaction occurred after the thermal treatments. Reaction progress and densification evolutions were established. DenseTriplex composite materials were achieved after 1500 1C treatments. The reaction-sintering was followed by XRD, TG?DTA, and dilatometry.Densification started at 1100 1C and the chemical reactions only started above 1300 1C. Aluminum titanate (Al2TiO5) was found to be anintermediate of the reaction after 1400 1C treatments. Materials treated below 1300 1C presented a partial densification of the unreacted startingpowders. Resulting ceramic materials were characterized. The crystalline phases were evaluated, as well as the texture properties. The achievedmicrostructure consisted in interlocked multiphase ceramic with zirconia (monoclinic) grains. The achieved Hv and KIC reached 9 GPa and4.3 MPa m1\/2 respectively. The dense and interlocked ceramic microstructure and relative high mechanical properties of the developed materialencourages several high temperature applications. Finally it can be pointed out that after 1500 1C treatments some detrimental grain growth wasobserved.& 2015 Elsevier Ltd and Techna Group S.r.l. All","palabras_clave":"Processing; |Mullite|Properties|Zirconia|Zirconium titanate"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":5262,"idioma_id":4,"titulo":"Chemical and sensory quality preservation in coated almonds with the addition of antioxidants","resumen":"Almonds provide many benefits such as preventing heart disease due to their high content of oleic fatty acid-rich oil and other important nutrients. However, they are susceptible to oxidation reactions causing rancidity during storage. The objective of this work was to evaluate the chemical and sensory quality preservation of almonds coated with carboxymethyl cellulose and with the addition of natural and synthetic antioxidants during storage. Four samples wereprepared: almonds without coating (C), almonds coated with carboxymethyl cellulose (CMC), almonds coated with CMC supplemented with peanut skins extract (E), and almonds coated with CMC and supplemented with butylhydroxytoluene(BHT). Proximate composition and fatty acid profile were determined on raw almonds. Almond samples (C, CMC, E and BHT) were stored at 40 °C for 126 d. Lipid oxidation indicators: peroxide value (PV), conjugated dienes (CD), volatile compounds (hexanal and nonanal), and sensory attributes were determined for the stored samples. Samples showed small but significant increases in PV, CD, hexanal and nonanal contents, and intensity ratings of negative sensory attributes (oxidized and cardboard). C had the highest tendency to deterioration during storage. At the end of storage (126 d), C had the highest PV (3.90 meqO2\/kg), and BHT had the lowest PV (2.00 meqO2\/kg). CMC and E samples had similar intermediate PV values (2.69 and 2.57 meqO2\/kg, respectively). CMC coating and the addition of natural (peanut skin extract) and synthetic (BHT) antioxidants provide protection to the roasted almond product.","palabras_clave":"ALMOND|PEANUTS|ANTIOXIDANT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":5300,"idioma_id":4,"titulo":"Arbuscular mycorrhizal fungal diversity in rhizosphere spores versus  roots of an endangered endemic tree from Argentina: Is fungal diversity  similar among forest disturbance types?","resumen":"P { margin-bottom: 0.21cm; }The aim of this study was to comparethe arbuscular mycorrhizal fungal (AMF) community of the rhizosphereand inside the roots of the perennial Polylepis australistree. Three forest types differing in their structural complexitydue to anthropogenic disturbances were chosen at three differentsites at the high mountains of central Argentina. Rhizosphere sporesand P. australis roots of four randomly selected treeswere isolated from 36 soil samples, DNA was extracted and the 18SrDNA fragments were amplified by nested-PCR. The products wereanalyzed by DGGE and the bands were excised for sequencing. Intotal, 36 OTUs were defined from 56 DGGE bands successfullysequenced. Forest disturbance types showed similar communities ofAMF, as rhizosphere spores and within the roots of P.australis. However, DGGE clustering showed mainly differencesbetween rhizosphere spores and root-colonizing AMF. Members ofGlomeraceae, Pacisporaceae, Acaulosporaceae and Gigasporaceae wereshown in rhizosphere spore samples. Root samples showed only membersof Acaulosporaceae and Gigasporaceae, which might be complementary interms of soil resources exploration. The prevalence of the rootsystem with their community of symbionts might explain the resilienceof AMF soil communities to forests structural changes. This studypresents evidence of a possible preference in the AMF?P. australisinteraction.","palabras_clave":"Glomeromycota|symbionts|soil|Polylepis australis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":5425,"idioma_id":4,"titulo":"The enhancement of invasion ability of an annual grass by its fungal endophyte depends on recipient community structure","resumen":"Most terrestrial plants establish symbioticassociations with microorganisms that enable them toovercome abiotic or biotic filters in ecosystems. Herewe investigated how aerial mutualisms involvinginvasive species may affect the recipient community?sstructure. We hypothesized that the endophyte Epichloe¨occultans enhances the ability of Lolium multiflorumto establish and colonize, but that successwould depend on the structure and invasion resistanceof the recipient grassland community. Seeds of L.multiflorum with high (E?) and low (E-) endophyteincidence were sown in plots located in grasslandswith or without recent grazing history. Relative coverof L. multiflorum and floristic groups was determinedduring the growing season. Whereas we did not detectany endophyte effect in sites with grazing history, L.multiflorum cover was 63 % in E? and 27 % in Eplotsin sites without grazing history. As cover of L.multiflorum increased in these sites, the cover ofwarm- and cool-season grasses decreased in spring,with that of warm-season grasses continuing todecrease in summer. These decreases correspondedto 1.9, 3.7 and 1.6 %, for every % increase of L.multiflorum cover. Path analysis and posterior modellingpredicted a greater impact of the endophyte onL. multiflorum cover than of seed addition whenresident L. multiflorum cover was B20 %. This effectdecreased asymptotically as L. multiflorum coverincreased beyond 20 %. Our results suggest that theendophyte may boost the invasion ability of L.multiflorum particularly in natural grassland withoutgrazing history with potential longer-term consequencesfor community structure and dynamics.","palabras_clave":"Lolium multiflorum|Epichloë occultans|Grass-endophyte symbiosis|Grassland functional groups"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":5506,"idioma_id":4,"titulo":"Serum Cytokines as Biomarkers of Early Trypanosoma cruzi infection by Congenital Exposure","resumen":"Trypanosoma cruzi, the causing agent of Chagas disease, leads to an activation of the immune system in congenitally infectedinfants. In this study, we measured a set of cytokines\/chemokines and the levels of parasitemia by quantitative PCR in thecirculation of neonates born to T. cruzi?infected mothers to evaluate the predictive value of these mediators as biomarkers ofcongenital transmission.We conducted a retrospective cohort study of 35 infants with congenital T. cruzi infection, of which 15 and10 infants had been diagnosed by detection of parasites by microscopy in the first and sixth month after delivery, respectively, andthe remaining 10 had been diagnosed by the presence of T. cruzi?specific Abs at 10?12 mo old. Uninfected infants born to eitherT. cruzi?infected or uninfected mothers were also evaluated as controls. The plasma levels of IL-17A, MCP-1, and monokineinduced by IFN-g were increased in infants congenitally infected with T. cruzi, even before they developed detectable parasitemiaor seroconversion. Infants diagnosed between 6 and 12 mo old also showed increased levels of IL-6 and IL-17F at 1 mo of age.Conversely, infants who did not develop congenital T. cruzi infection had higher levels of IFN-g than infected infants born touninfected mothers. Monokine induced by IFN-g, MCP-1, and IFN-g production induced in T. cruzi?infected infants correlatedwith parasitemia, whereas the plasma levels of IL-17A, IL-17F, and IL-6 were less parasite load dependent. These findings supportthe existence of a distinct profile of cytokines and chemokines in the circulation of infants born to T. cruzi?infected mothers, whichmight predict congenital infection.","palabras_clave":"TRYPANOSOMA CRUZI|CONGENITAL TRANSMISSION|CYTOKINE|CHEMOKINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":5635,"idioma_id":4,"titulo":"Systematics of the breakup probability function for 6Li and 7Li projectiles","resumen":"Experimental non-capture breakup cross sections can be used to determine the probability of projectile and ejectile fragmentation in nuclear reactions involving weakly bound nuclei. Recently, the probability of both type of dissociations has been analyzed in nuclear reactions involving 9Be projectiles onto various heavy targets at sub-barrier energies. In the present work we extend this kind of systematic analysis to the case of 6Li and 7Li projectiles with the purpose of investigating general features of projectile-like breakup probabilities for reactions induced by stable weakly bound nuclei. For that purpose we have obtained the probabilities of projectile and ejectile breakup for a large number of systems, starting from a compilation of the corresponding reported non-capture breakup cross sections. We parametrize the results in accordance with the previous studies for the case of beryllium projectiles, and we discuss their systematic behavior as a function of the projectile, the target mass and the reaction Q-value.","palabras_clave":"WEAKLY BOUND PROJECTILES|NON-CAPTURE BREAKUP CROSS SECTIONS|BREAKUP PROBABILITY FUNCTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":5772,"idioma_id":4,"titulo":"Eolian deposits of the southwestern margin of the Botucatú paleoerg: Reconstruction of the Gondwana landscape in Central Northern Argentina","resumen":"TheMesozoic Botucatú paleoerg at the southwestern margin of Gondwana includes a succession of eolian dunes cross-strata which are presently exposed in Otumpa Hills (Central Northern Argentina). Here, the architectural facies, petrology, and provenance of those rocks were studied in order to investigate depositional environments and paleoclimates. The stratigraphic sequence included basal eolian two-dimensional crescentic dunes (Slp) overlain by three-dimensional crescentic dunes of smaller scale (Smt). These were correlated with the Upper Member Rivera of the Tacuarembó Formation (Uruguay), or its equivalent in Brazil, the Botucatú Formation. These outcrops partially mark the southwestern margin of the Botucatú paleoerg along the Chaco?ParanáBasin boundary. The paleocurrents from the W, NW, and SW and the U?Pb ages of detrital zircons indicate a main Pampean cratonic and secondary Andean magmatic arc (180 Ma) source. A detrital zircon of 180 Ma by U?Pb limits a maximum depositional age at 180 Ma (Toarcian) for facies Slp. Upwards, the phreatic silcrete and calcrete indicate semiarid conditions during the Paleocene, which are correlated with the Queguay Formation of Uruguay. A saprolite paleoweathering profile, recording wet tropical?hyper-tropical climate at the Early Eocene and representing the Gondwana landscape and climate conditions, crowns the sequence. This study represents the first provenance and surface texture analysis of minerals from the Botucatú paleoerg and was instrumental to unravel past environmental and sedimentary conditions.","palabras_clave":"BOTUCATÚ PALEOERG|GONDWANA LANDSCAPE|CHACO-PAMPEAN PLAIN|OTUMPA HILLS|RIVERA MEMBER OF TACUAREMBÓ FORMATION|BOTUCATÚ FORMATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":5818,"idioma_id":4,"titulo":"Delivery of fluorophores by calcium phosphate-coated nanoliposomes and interaction with Staphylococcus aureus biofilms","resumen":"The delivery capacity and mechanical stability of calcium phosphate (CaP) coated 1,2-dioleoyl-sn-glycero-3-phosphate (DOPA) liposomes free and adsorbed on bacterial surface was investigated introducing either acridine orange (AO) or 5,10,15,20-Tetrakis(1-methyl-4-pyridinio)porphyrin (TMP) in the aqueous core of the liposomes. The obtained nanomaterials were thoroughly characterized by electron and optical microscopy and by fluorescence techniques. Distribution of the AO and TMP molecules between the aqueous liposomes core and the outer solution was demonstrated by the band shifts and broadening of the excitation?emission matrices and the modified Stern-Volmer model for fluorescence quenching. In aqueous suspensions, c.a. 40% of AO was released to the outer solution while only a small percentage of TMP was observed to reach the outer liposome surface. The nanoliposomes adhesion capacity and the leaking of fluorophore molecules to Staphylococcus aureus (S. aureus) biofilms were further evaluated. A close interaction between liposomes and S. aureus biofilm was evidenced by TEM and SEM imaging. Epifluorescence experiments demonstrated that CaP-coated liposomes have good biofilm staining capability after two hours incubation of the biofilms with the liposomes, thus supporting an important release of the fluorophores when in contact with the biofilm. Altogether, the obtained results strongly suggest that CaP-coated liposomes are capable of activating drug release when in presence of S. aureus biofilms and smears. The studies herein presented, indicate that CaP-coated liposomes are potential vehicles for the selective delivery of drugs to S. aureus biofilms, as is the case of the singlet oxygen photosensitizer TMP, a well known photodynamic antibacterial agent.","palabras_clave":"FLUOROPHORES|NANOLIPOSOME"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":6068,"idioma_id":5,"titulo":"Mancha amarilla y roya de la hoja en trigo. ¿Cómo afectan la tasa de crecimiento del cultivo?","resumen":"El trabajo investiga como afectan los patógenos foliares del trigo como mancha amarilla y roya de la hoja la tasa de crecimiento del cultivo","palabras_clave":"MANCHA AMARILLA|ROYA DE LA HOJA|BIOMASA|RADIACION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":6157,"idioma_id":4,"titulo":"Endophytes from wheat as biocontrol agents against tan spot disease","resumen":"Endophytes from wheat cultivars isolated in Buenos Aires province, Argentina, were assessed for their potential as biocontrol agents against Pyrenophora tritici-repentis (Died.) Drechsler (anamorph Drechslera tritici-repentis) (Died.) Shoem (Dtr), the causal agent of tan spot of wheat. Endophytes were screened using dual culture techniques and examining the effect on growth, sporulation and the antifungal activity in greenhouse assays. The most of endophytes tested significantly reduced Dtr growth compared to the control except Rhodotorula rubra from 11 to 15 days post inoculation. Trichoderma hamatum, Penicillium sp., Bacillus sp. and Paecilomyces lilacinus significantly reduced the colony diameter of the pathogen. Most of the endophytes evaluated showed morphological changes in the conidia and\/or the mycelia of D. tritici-repentis. In addition, two endophytes, Bacillus sp. and Fusarium sp., reduced significantly the percent spore germination of Dtr compared to the control by 82% and 52% respectively. In greenhouse experiment T. hamatum, Chaetomium globosum and Fusarium sp. significantly (P &#10877; 0.05) reduced the average disease severity on all three leaves compared to the control. However, the best antagonistic effect was shown with T. hamatum as it resulted in the greatest suppression in the greenhouse and in the dual-plate assays. Likewise, Bacillus sp. was other highlighted microorganism that antagonized the pathogen in in vitro assays. From our promising results, we conclude that endophytes have potential in the biological control of tan spot of wheat caused by D. tritici-repentis, particularly T. hamatum and Bacillus sp.","palabras_clave":"Endophytes|Drechslera tritici repentis|Pyrenophora tritici repentis|wheat"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":6399,"idioma_id":5,"titulo":"Cuestionario de Evaluación de Estilos, Modalidades y Tipos de Acoso Laboral (CEMTAL): Estructura y Propiedades Psicométricas","resumen":"-","palabras_clave":"ACOSO LABORAL|CUESTIONARIO|ESTRUCTURA FACTORIAL|CONFIABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":6462,"idioma_id":5,"titulo":"Integrando los cuerpos de agua al paisaje del Parque: la trama invisible de las cuencas","resumen":"El Parque Nacional Nahuel Huapi incluye una de las cuencas de cabecera más importantes de la red fluvial norpatagónica, abarcando lagos de altura y arroyos que alimentan a los grandes lagos pedemontanos de origen glaciario. Estos ecosistemas son una parte central del paisaje por su carácter escénico y su prestación de servicios. Además cumplen un rol vital en el transporte y distribución del agua y materiales de la cuenca, sustentando parcialmente las comunidades biológicas a lo largo de la red fluvial. En este trabajo se sintetizan estudios focalizados en la cuenca del complejo lacustre Moreno que describen aspectos geomorfológicos y revelan el aporte de los suelos y del bosque nativo a los arroyos y lagos. Estos aportes incluyen materiales particulados, materia orgánica disuelta (MOD) y nutrientes, siendo su ingreso en la red fluvial de la cuenca fuertemente ligado al régimen de precipitación y al deshielo. Los arroyos de cabecera actúan como conductores de los materiales disueltos recibidos de la cuenca con bajo grado de procesamiento y aprovechamiento interno (particularmente la MOD); mientras que en los lagos la MOD terrestre subsidia las tramas tróficas pelágicas, observándose hasta un 15% de Carbono (C) de origen terrestre en los consumidores planctónicos. Por último, considerando un marco de cambio ambiental con fuertes fluctuaciones en el régimen de precipitación regional, temperaturas en alza e incremento de la actividad humana y el uso de la tierra, especulamos posibles efectos sobre las cuencas de cabecera andino-patagónicas","palabras_clave":"LAGOS Y ARROYOS ANDINO PATAGÓNICOS|MATERIA ORGÁNICA DISUELTA|FLUJO DE MATERIA Y ENERGIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":6499,"idioma_id":4,"titulo":"Does land use change alter water and nutrient dynamics of phreatophytic trees in the Central Monte desert ?","resumen":"In the Central Monte desert, livestock and settlement activity can permit water to pass through the soil profile and facilitate deep water drainage and nitrate lixiviation into the groundwater table. We hypothesize that the activities associated with livestock stations, mainly nutrient inputs and partial vegetation removal, may increase soil resources and relieve competition. Consequently, this relieves water stress and increases the growth of the remaining trees at livestock stations. The goal of this research was to analyze the physiological responses of Prosopis flexuosa trees in two different land use regimes, and the changes in the&nbsp; environmental factors controlling these responses. In four paired sites of relatively undisturbed control woodlands and livestock stations, we compared the ecophysiological responses of adult P. flexuosa trees in the 2011-2013 growing seasons. Both growth of new leaves (number of leaves and foliar area) and the length of young branches were higher in the first season for both land uses, but branch length was higher in livestock stations. Pre-dawn and midday leaf water potential and stomatal conductance were slightly higher in livestock stations than in control woodlands, suggesting a better water status of P. flexuosa in livestock stations. Foliar nitrogen concentration and isotopic composition (lower &#948; 13 C, and higher &#948; 15 N and %N values) indicatedlower water use efficiency and higher nitrogen absorption from the soil in livestock stations. This is consistent with the proposal that the vegetation removal and nutrient contribution of settlement activities improved the water and nutrient status of remaining vegetation, and modified the relative importance of factor controlling ecophysiological processes. Weconcluded that physiological responses and vegetative growth of P. flexuosa were not only affected by meteorological conditions (rainfalls, vapor pressure deficit), but also by the ecohydrological changes caused by changes in land use.","palabras_clave":"ALGARROBO WOODLANDS|DISTURBED ARID LAND|TREE PHYSIOLOGY|PHREATOPHYTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":7124,"idioma_id":5,"titulo":"TRABAJO DE EXTENSION CONJUNTO ENTRE LAS FACULTADES DE INGENIERIA Y DE ARQUITECTURA DE LA UNNE: CAPACITACION EN ENERGIAS RENOVABLES Y ARQUITECTURA SUSTENTABLE","resumen":"Se comentan los fundamentos, objetivos, metodología y principales resultados de la implementación de un proyecto de Extensión Universitaria de la UNNE, presentado y aprobado en la convocatoria del año 2013 del Programa La Universidad en el Medio, ejecutado durante el año 2014. Dicho proyecto fue desarrollado en conjunto entre las Facultades de Ingeniería y de Arquitectura de la UNNE, concretamente, entre elGrupo GIDER (FI-UNNE) y la cátedra Estructuras II (FAU-UNNE). El proyecto se denominó Capacitación en energías renovables y arquitectura sustentable: construcción y puesta en funcionamiento de una cocina solar y un biodigestor (proyecto N.º 42 - Res. N.º 005\/14-C. S. UNNE).","palabras_clave":"EXTENSION|CAPACITACION|ENERGIAS|SUSTENTABLE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":7598,"idioma_id":4,"titulo":"effect of infrequent wheat pasture supplementation on in vivo DM and NDF digestibility and nitrogen retention of pregnant beef cows consuming deferred sorghum","resumen":"An in vivo study was performed using 8 British-breed, eighth-month gestating (420±15 Kg of BW) beef cows to determine the effect of infrequent wheat pasture supplementation on in vivo Organic Matter (OM) and Nitrogen Detergent Fiber (NDF) digestibility and nitrogen retention (NR). Treatments consisted on an unsupplemented control (Deferred sorghum, DS) and DS plus fresh wheat forage (DSW) offered three times per week. Cows were allotted in a completed randomized design for a period of 17 days. DS intake decreased (p<0.05) with CP supplementation, total OM intake (OMI) was not different (p=0.18) between treatments while NDF intake was greater (p<0.05) in DS than in DSW. Apparent total-tract OM digestibility (OMD) was higher (p<0.05) in DSW than in DS and apparent total-tract NDF digestibility (NDFD) did not differ among treatments.  N intake was greater in supplemented than in control cows. Feces and urine N did not differ between treatments (p=0.27) and NR was higher in DSW. NR expressed as percentage of N consumed was not different between treatments. These results suggest that wheat pasture (18.4% PC and 45.6% NDF) can be used as CP supplement for cows consuming low quality forage even if it is offered three times per week.","palabras_clave":"LOW QUALITY FORAGE|DIGESTIBILITY|PROTEIN|COW"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":7739,"idioma_id":5,"titulo":"Resolución de problemas numéricos de Química. El rol de la justificación explícita.","resumen":"Eneste trabajo, se presentan un texto, un esquema basado en el modeloArgumental de Toulmin para la resolución de un problema numéricointegrado y el análisis de las justificaciones expresadas por losestudiantes en un examen. La justificación que se muestra es lo quehabitualmente se discute en las clases de aula y de laboratorios y,luego en los exámenes, se la pide explícitamente. Los estudiantessuelen tomar correctas decisiones y logran resolver con éxitodeterminados procedimientos. Éstos son los que están correctamentejustificados. No así aquellos procedimientos y decisiones que tomanmecánicamente, sin justificar y que, a veces, les permite concluirbien pero no saben por qué. Por ello, sostenemos que los estudiantesdeben mejorar sus textos justificativos desde el punto de vistaformal para una mayor comprensión de los conceptos científicos yuna óptima aplicación en resolución de problemas numéricos. p { margin-bottom: 0.25cm; line-height: 120%; }a:link { color: rgb(0, 0, 255); }","palabras_clave":"QUÍMICA|PROBLEMAS NUMÉRICOS INTEGRADOS,|JUSTIFICACIÓN, |TEXTOS JUSTIFICATIVOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":7740,"idioma_id":5,"titulo":"Capacidades que contribuyen al desarrollo de las competencias genéricas ?resolución de problemas? y ?comunicarse con efectividad","resumen":"Eneste trabajo presentamos los resultados de una investigación que serealizó durante el 2015 respecto de conocer las capacidades yhabilidades de los estudiantes cuando inician el curso y cuáles sefortalecieron o se adquirieron al finalizar el mismo. p { margin-bottom: 0cm; direction: ltr; color: rgb(0, 0, 0); text-align: justify; }p.western { font-family: 'Times New Roman', serif; font-size: 10pt; }p.cjk { font-family: 'Times New Roman', serif; font-size: 10pt; }p.ctl { font-family: 'Times New Roman', serif; font-size: 10pt; }a:link { color: rgb(0, 0, 255); }","palabras_clave":"COMPETENCIAS|RESOLUCIÓN DE PROBLEMAS|JUSTIFICAR,|ARGUMENTAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":7741,"idioma_id":5,"titulo":"Conciencia ambiental y química verde. Análisis histórico para su implementación en la docencia","resumen":"Eneste trabajo se abordan los conceptos de Conciencia Ambiental yQuímica Verde, y cómo fueron construyéndose a través del tiempoen el aporte de la búsqueda de una solución a los problemasambientales. Se describe la propuesta de la Química Verde, comoalternativa técnica frente a un problema ambiental. Se analizanalgunas limitaciones fundamentales para ser consideradas en laenseñanza de la Química desde el paradigma de la complejidad, comolos riesgos y las incertidumbres. Se presenta una propuesta acotadapara su incorporación en los PEI y en otras instancias educativasformales. p { margin-bottom: 0.21cm; direction: ltr; color: rgb(0, 0, 0); text-align: left; }p.western { font-family: 'Liberation Serif', 'Times New Roman', serif; font-size: 12pt; }p.cjk { font-family: 'WenQuanYi Micro Hei', 'Arial Unicode MS'; font-size: 12pt; }p.ctl { font-family: 'Lohit Hindi', 'Arial Unicode MS'; font-size: 12pt; }a.western:link { }a.ctl:link { }","palabras_clave":"CONCIENCIA AMBIENTAL|QUÍMICA VERDE|ANÁLISIS HISTÓRICO|DOCENCIA."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8241,"idioma_id":4,"titulo":"An estimation of the effect of a possible wind speed increase on the ocean mixed layer depth at the northern Patagonian continental shelf","resumen":"A possible deepening of the ocean mixed layer is investigated at two selected points of the Patagonian continental shelf where a significant positive wind speed trend is estimated. Using a 1-dimensional vertical numerical model on a long term simulation (1979?2011) it is found that the mixed layer thickness presents a significant and positive trend of about 10±1.5&nbsp;cm\/yr. The model is forced by atmospheric data from NCEP\/NCAR 1 reanalysis and tidal constituents from TPXO 7.2 global model. Several numerical experiments are carried out in order to evaluate the impact of the different atmospheric variables considered in this study (wind components, air temperature, atmospheric pressure, specific humidity and cloud coverage). As a result it is found that a possible increase in the wind speed should be considered as a very significant factor for deepening the ocean mixed layer at the northern Patagonian continental shelf.","palabras_clave":"PATAGONIA|SHELF|WIND|THERMOCLINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8320,"idioma_id":5,"titulo":"Filosofía experimental de la ciencia: el concepto de observación en I. Hacking.","resumen":"Uno de los problemas clásicos de la filosofía de la ciencia es la relación entre teoría y observación. El concepto de observación se encuentra en la base de muchas cuestiones epistemológicas y metodológicas de la ciencia y la posición asumida respecto a la relación   con las teorías incide en el proceso de caracterización y evaluación del conocimiento científico. En este trabajo analizaremos los  enfoques dominantes respecto a esta relación: 1) el enfoque de  la  filosofía de la ciencia clásica,  que establece la  independencia  entre el lenguaje observacional y el teórico y  la  confirmación de las teorías a partir de la  contrastación con las observaciones, que deben ser puras, es decir, no prejuiciadas ni contaminadas en sentido alguno por las teorías; 2) el enfoque de Thomas Kuhn,  que sostiene que  toda observación requiere de creencias o conocimientos previos y, más aún, que las observaciones siempre se realizan bajo la influencia de alguna concepción acerca del mundo; 3) la propuesta de Ian Hacking, que distingue la teoría de la observación, pero ésta última considerada  como una actividad diversa y con autonomía de la teoría, lo que  constituye el fundamento de una filosofía experimental de la ciencia.","palabras_clave":"observación|teoría|filosofía experimental"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8397,"idioma_id":5,"titulo":"Prevención Secundaria del desarrollo fonológico en niños de Nivel Inicial","resumen":"Esta investigación pretende llevar la prevención secundaria fonoaudiológica al ámbito escolar, porque es allí donde comienzan los aprendizajes formales del infante.Se pretende determinar el desarrollo fonológico en niños de Nivel Inicial que asisten a la escuela pública.El complejo proceso del lenguaje se desarrolla en los niños en la medida que se van dando procesos de maduración, crecimiento y desarrollo. Cuando el lenguaje llega a un nivel maduro, se presenta con las siguientes perspectivas: Semántica, Sintáctica, Pragmática y Fonológica.La prevención implica desarrollar acciones anticipatorias, con el fin de promocionar el bienestar del ser humano y así evitar situaciones indeseables.            En este trabajo se implementa el Instrumento de Evaluación Fonológica de Laura Bosch Galceran que evalúa niños de 3 a 7 años, y analiza las adquisiciones fonológicas que se producen en esa edad, periodo relacionado con la etapa de educación infantil, para facilitar así la detección de problemas evolutivos del habla en el marco escolar y\/o clínico.","palabras_clave":"LENGUAJE|DESARROLLO FONOALOGICO|PREVENCION|NIÑOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8491,"idioma_id":4,"titulo":"Regulation of NF-kB signalling cascade by immunophilins","resumen":"The fine regulation of signalling cascades is a key event required to maintain the appropriate functional properties of a cell when a given stimulus triggers specific biological responses. In this sense, cumulative experimental evidence during the last years has shown that high molecular weight immunophilins possess a fundamental importance in the regulation of many of these processes. It was first discovered that TPR-domain immunophilins such as FKBP51 and FKBP52 play a cardinal role, usually in an antagonistic fashion, in the regulation of several members of the steroid receptor family via its interaction with the heat-shock protein of 90-kDa, Hsp90. These Hsp90-associated cochaperones form a functional unit with the molecular chaperone influencing ligand binding capacity, receptor trafficking, and hormone-dependent transcriptional activity. Recently, it was demonstrated that the same immunophilins are also able to regulate the NF-kB signalling cascade in an Hsp90 independent manner. In this article we analize these properties and discuss the relevance of this novel regulatory pathway in the context of the pleiotropic actions managed by NF-kB in several cell types and tissues.","palabras_clave":"Inmunofilina|NF-kB|Cancer|FKBP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8520,"idioma_id":5,"titulo":"Estudio del vocabulario en un corpus de artículos de investigación en Ecología","resumen":"Estudios  recientes  han  demostrado  la  importancia  de  desarrollar listas de palabras específicas para cada disciplina que cumplan con las necesidades de los escritores y lectores hispano-parlantes cuando deben leer o redactar un texto en inglés. Para elaborar listas de palabras en el área de ecología, este estudio investigó, en una primera etapa, el vocabulario de un corpus de artículos de investigación de ecología, y en una segunda etapa, las palabras de alta frecuencia del corpus. En  la  primera  etapa  se  utilizó  metodología  de  corpus,  una  lista  de palabras generales y una lista de palabras académicas disponibles en la bibliografía. En la segunda etapa se analizaron y categorizaron las palabras de alta frecuencia usando criterios semánticos y pragmáticos. El análisis reveló que muchas de las palabras generales y académicas del corpus pertenecen al campo semántico de la ecología, por lo que podrían  considerarse  palabras  especializadas.  Esto  determinó  la recategorización de las palabras en técnicas y no técnicas según su significado y uso en el contexto específico de los artículos de ecología. A partir de esta reclasificación se construyeron dos listas de palabras que aportan datos para el diseño de materiales pedagógicos para los cursos  de  lectura  y  escritura  científica  y  académica  dictados  en  la UNRC.","palabras_clave":"vocabulario|corpua|artículo de investigación|ecología"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8539,"idioma_id":4,"titulo":"Evidence of populations of Mugil curema in Southeastern Caribbean Sea? Otolith microchemistry as a potential method","resumen":"The aim of the present study was to evaluate the potential use of otolith microchemistry (Sr:Ca y Ba:Ca ratios) to identify silver mullet,Mugil curema,populations inSoutheastern Caribbean Sea.Fish samples were collected in 7 areas of Nueva Esparta State (Venezuela). The otolith Sr:Ca and Ba:Ca ratios and water Sr:Ca were determined (by ICP-OES and EDTA volumetric method). Otoliths Sr:Ca and Ba:Ca ratios and Sr:Ca partition coefficient of mullets in Cubagua island (south of the State) were significantly different from ratios in La Guardia (north of the State). A discriminant analysis of otolith Sr:Ca and Ba:Ca ratios separated Cubagua Island from La Guardia values. These results suggest the existence of different mullet groups in the Southeastern Caribbean Sea. For this, the simultaneous use of Sr:Ca and Ba:Ca ratios could be a potential tool to identify populations in the study area.","palabras_clave":"Mugilidae|Fish resource|Otolith|Microchemistry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8556,"idioma_id":4,"titulo":"Novel topical formulation for ischemic chronic wounds. Technological design, quality control and safety evaluation","resumen":"Ulceration of the foot in diabetes is common and disabling, and frequently leads to amputation of the leg. The pathogenesis of foot ulceration is complex, clinical presentation variable and  management requires early expert assessment. Despite treatment, ulcers readily become chronic wounds. Chronic wounds are those that remain in a chronic inflammatory state failing a normal healing process patterns. This is partially caused by inefficient eradication of opportunistic  pathogens like Pseudomonas aeruginosa. We propose its control or eradication will promote wound healing. Lactobacillus plantarum cultures supernatants (LAPS) shows antipathogenic and pro-healing properties. The main objective was to design two pharmaceutical dosage forms by using LAPS as active pharmaceutical ingredient and to perform its quality control, in vitro activity conservation tests and human trials (safety evaluation). Both selected formulations reach the technological quality expected for 120 days, shows adequate occlusive characteristics and  proper adhesion to human skin. From the in vitro release assays were found that LAPS shows adequate release from matrix and maintain its antimicrobial and anti-biofilm activity. First human trials were developed and neither edema nor erythema on healthy skin voluntaries was found. We conclude that C80 and C100 are adequate for their use in future clinical trials to demonstrate a comprehensive therapeutic effectiveness in ischemic chronic wounds.","palabras_clave":"BACTERIA BY PRODUCT|LACTOBACILLUS PLANTARUM|PSEUDOMONAS AERUGINOSA|QUALITY CONTROL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8577,"idioma_id":4,"titulo":"Allogeneic hematopoietic stem cell transplantation in adults with myelodysplastic syndrome: Experience of the Argentinean Group of Bone Marrow Transplantation (GATMO)","resumen":"INTRODUCTION:Allogeneic hematopoietic stem cell transplantation (AHSCT) is a curative approach for patients with myelodysplastic syndrome (MDS).METHODS:In this multicenter retrospective study, we analyzed the outcome of adult patients with MDS who underwent AHSCT in Argentina and evaluated the prognostic factors associated with progression-free survival (PFS), overall survival (OS), cumulative incidence (CI) of relapse, and non-relapse mortality (NRM).RESULTS:We analyzed data from 87 adults (median age: 43 years, range 18-66) who underwent SCT after myeloablative (n&#8201;=&#8201;60) or non-myeloablative conditioning (n&#8201;=&#8201;27), and from related (n&#8201;=&#8201;62) or unrelated (n&#8201;=&#8201;25) donors. For all patients, unadjusted 4-year PFS and OS were 37% and 38%, respectively; no significant differences were found between recipients of related or unrelated donors. One-year CI of relapse and NRM were 21% and 20%, respectively. In the multivariate analysis, intermediate disease risk index (DRI) and acute graft versus host disease AGVHD of all grades (I-IV) were independent variables associated with better PFS and lower relapse CI; only intermediate DRI was associated with better OS.CONCLUSIONS:AHSCT is a feasible procedure in Argentina, with more than 30% of the patients achieving long-term survival. Recipients with unrelated donors had at least similar outcome than those with related donors. DRI may be useful to identify patients at higher risk of relapse after transplantation.","palabras_clave":"Disease risk index|Myelodysplastic syndrome|Relapse| Stem cell transplantation|Survival|Unrelated donors"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8605,"idioma_id":5,"titulo":"Primer registro de Drosophila suzukii (Diptera: Drosophilidae) asociado al cultivo de arándanos (Vaccinium spp.) en Argentina.","resumen":"La presencia de la especie de origen asiático Drosophila suzukii (Matsumura),conocida como ?drosophila de las alas manchadas?, fue detectada alimentándosede frutos de arándano (Ericaceae) en la localidad de Lobos, provinciade Buenos Aires. Esto constituye el primer registro de esta importante plaga sobreeste cultivo en Argentina.","palabras_clave":"Moscas del vinagre|Plagas exóticas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8701,"idioma_id":4,"titulo":"The Fourier Transform of ((G(x,m))+&#955;","resumen":"Abstract:We know from(G,page284) that the Fourier transform of P&#8330;^{&#955;} and P&#8331;^{&#955;} are given by the formulae(4) and(5) respectively. In this article using another method we obtain the Fourier transform of P&#8330;^{&#955;} and P&#8331;^{&#955;}, where P=P(x) is defined by(1), P&#8330;^{&#955;} by(8) and P&#8331;^{&#955;} by(9). We prove that our formulae(44)and(82) are equivalent to formulae(4)and(5) respectively.","palabras_clave":"DISTRIBUTIONS|FOURIER TRANSFORM|ULTRAHYPERBOLIC KERNEL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8711,"idioma_id":5,"titulo":"Bienestar Animal de hembras reproductoras porcinas","resumen":"En las últimas décadas el Bienestar Animal ha ido aumentando en importanciatanto moral, como económica. En Argentina hay, en la actualidad, restricciones encuanto al transporte, sacrificio y alojamiento de los animales para consumo, pero noexisten recomendaciones respecto al alojamiento de las hembras, y son las cerdasmadres quienes permanecen más tiempo en el plantel de una granja. A partir delinterés demostrado por la sociedad, grupos de investigadores comenzaron arealizar estudios referidos a diversas respuestas de los animales frente avariaciones en su ambiente de producción, tanto en su alojamiento como en elmanejo general del sistema. El objetivo de este trabajo es hacer una revisión dealgunos de esos estudios y comentar las experiencias de distintos colegas respectoa este tema. El conocimiento empírico de los Médicos Veterinarios que actualmentese desempeñan como responsables de la productividad y sanidad de granjasporcinas permite elaborar propuestas de evaluación para mejorar la eficienciaproductiva del establecimiento, con el fin de acceder a esta información serealizaron entrevistas a Médicos Veterinarios asesores de 140 granjas porcinas. Yfinalmente, en forma de ejemplo se analiza un caso que incluye 2 modelos deproducción de cría intensiva confinada; se realiza la comparación de dos grupos dehembras porcinas nulíparas, uno de ellos constituido por hembras alojadas enjaulas individuales y el otro conformado por hembras que gestaron en corral grupa","palabras_clave":"Porcino|Etología|Bienestar Animal"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8836,"idioma_id":5,"titulo":"De emociones e investigación. Reflexiones a partir de un suceso durante el trabajo de campo","resumen":"¿De qué manera nos involucramos durante el trabajo de campo? ¿Qué rol nos asignan nuestros interlocutores?¿De qué modo se involucran nuestras emociones y capitales sociales en las relaciones que construimos? A partir de revisitar una situación acontecida durante el desarrollo de mi investigación, el propósito de este artículo es reflexionar sobre el papel que vamos ocupando los  investigadores durante nuestro trabajo de campo y las diferentes posiciones que asumimos que, en ocasiones, desbordan nuestros intereses de investigación. En este sentido parto de la premisa que la figura del investigador no es algo dado y delimitado a priori, como una especie de uniforme que nos ponemos antes de ingresar al campo, sino que se va construyendo en la interacción con su objeto de estudio. Simultáneamente somos investigadores y personas insertas en redes de relaciones sociales, por medio de las cuales construimos vínculos e inevitablemente se involucran ?por más que le pese a las ciencias más duras- subjetividades, emociones y sentimientos.","palabras_clave":"GENERO|MIGRACIÓN|EMOCIONES|TRABAJO DE CAMPO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8850,"idioma_id":4,"titulo":"Consenso Argentino de Valvulopatias","resumen":"Los consensos son documentosvaliosos para difundir las mejores estrategias de diagnóstico y tratamiento;sin embargo, existen varios sobre enfermedades valvulares, por lo que cabepreguntarse por qué otro más.Elenfoque que le dimos a este Consenso permite compartir información y criteriosaceptados internacio­nalmente, pero además incluye una visión local a partir delos datos y la información existente en nuestro país, que se adapta a lascaracterísticas de disponibilidad de recursos, que es variable en distintaszonas geográficas y diferentes niveles económicos y de acceso a la salud. Lamayor parte de la bibliografía proviene de países centrales, y remarca laimportancia de los contrastes sociales, culturales y económicos en susresultados. Si bien estos países, de cuya información se nutren los consensosinternacionales, también poseen estas diferencias, en América Latina loscontrastes se profundizan haciendo de la extrapolación de resultados un trabajocomplejo y no siempre correcto. Uno de los ejemplos más ilustrativos de estasdificultades lo constituye la fiebre reumática que en muchos países delhemisferio norte es anecdótica y en nuestra región sigue vigente. Esta realidadimpacta en aspectos tales como la toma de decisiones en insuficiencia mitral,basada en estudios que no incluyeron esta etiología, lo cual puede conducir adecisiones terapéuticas erróneas. Otra carac­terística que nos diferencia esnuestra estadística sobre aplicación de recursos y resultados, que también nosobliga a una visión distinta en el momento de la toma de decisión, pues dichosdatos no siempre coinciden con los informados en otros países.","palabras_clave":"estenosis mitral|insuficiencia mitral|estenosis aórtica|insuficiencia aórtica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8871,"idioma_id":5,"titulo":"Procesos microbiológicos en Argiudoles con uso forestal y agrícola en el sur de la pampa ondulada","resumen":"Las forestaciones en la Región Pampeana se realizan desde aproximadamente un siglo, modificando la calidad y cantidad de residuos vegetales aportados al suelo, se analizaron sus efectos sobre la descomposición e incorporación de materia orgánica.  En  suelos Argiudoles del sur de la Pampa Ondulada, en junio y diciembre de 2013, con Robinia pseudoacacia acacia), Eucalyptus camandulensis (eucalipto), agricultura y pastizales, se determinó el carbono orgánico total (COT),  la respiración edáfica (RE),  la biomasa microbiana (BM),  el índice de mineralización (IM) y el cociente metabólico (Q). Cada tratamiento contó con tres repeticiones y cuatro submuestras. Los suelos en uso forestal tuvieron un tenor de COT similar al del suelo con pastizales, por lo que podemos afirmar que los sistemas forestales son conservativos de la materia orgánica del suelo. En los usos forestales y el pastizal, la variación de la actividad metabólica estacional se registró mediante los indicadores RE y BM, mientras que  IM y Q se mantuvieron estables. Estos indicadores resultaron parcialmente útiles para determinar las diferencias entre los usos. Los indicadores utilizados en el trabajo y las especies forestales tratadas son de uso global, por lo que esperamos que los resultados y la metodología  aporten al estudio de áreas forestadas con especies exóticas.","palabras_clave":"Procesos microbiológicos|Argiudoles|Uso forestal y agrícola"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8891,"idioma_id":4,"titulo":"Neglect in Human Communication: Quantifying the Cost of Cell-Phone Interruptions in Face to Face Dialogs","resumen":"There is a prevailing belief that interruptions using cellular phones during face-to-face interactions may affect severely on how people relate and perceive each other. We set out to determine this cost quantitatively through an experiment performed in dyads, in a large audience in a TEDx event. One of the two participants (the speaker) narrates a story vividly. The listener is asked to deliberately ignore the speaker during part of the story (for instance, attending to their cell-phone). The speaker, is not aware of this treatment. We show that total amount of attention is the major factor driving subjective beliefs about the story and the conversational partner. The effects are mostly independent on how attention is distributed in time. All social parameters of human communication are affected by attention time with a sole exception: the perceived emotion of the story. Interruptions during day-to-day communication between peers are extremely frequent. Our data should provide a note of caution, by indicating that they have a major effect on the perception people have about what they say (whether it is interesting or not...) and about the virtues of the people around them.","palabras_clave":"-"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8900,"idioma_id":4,"titulo":"Analgesia enhancement and prevention of tolerance to morphine: beneficial effects of combined therapy with omega-3 fatty acids","resumen":"Objectives. Recent evidence associates omega-3 fatty acids (O3) with pain reduction. The aim of this work was to evaluate the antinociceptive effect of O3, either alone or in combination with morphine after acute and chronic administration in rats. As well, a new pharmaceutical mixture that allows the concomitant administration of O3 and morphine as an oral solution was developed.Methods. Animals were fed on a control or an experimental diet supplemented with O3. They were subjected to the hot-plate test to assess analgesic effect and tolerance to the analgesic effect of morphine. The open-field test was carried out to determine if the differences in the response latency can be related to nonspecific sedative effects.Key findings. O3 dietary supplementation increased the response latency compared with the control group. Acute treatment with morphine in these groups resulted in an additive antinociceptive effect not related to locomotor activity. Chronic coadministration of morphine with O3 attenuated the development of tolerance. Oral administration of the new pharmaceutical mixture showed analgesic activity with a subtherapeutic dose of morphine.Conclusion. This finding suggests a role for O3 as adjuncts to opioids in pain therapy and might contribute to the reduction of the occurrence of morphine side-effects.","palabras_clave":"analgesia|morphine|omega 3-fatty acids"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":8903,"idioma_id":5,"titulo":"CARGADORES SOLARES PORTATILES PARA EL USO DE DISPOSITIVOS MOVILES EN ZONAS RURALES AISLADAS DEL NOA","resumen":"p { margin-bottom: 0cm; direction: ltr; color: rgb(0, 0, 0); widows: 2; orphans: 2; }p.western { font-family: 'Times New Roman',serif; font-size: 10pt; font-weight: bold; }p.cjk { font-family: 'Times New Roman',serif; font-size: 10pt; font-weight: bold; }p.ctl { font-family: 'Times New Roman',serif; font-size: 10pt; font-weight: bold; }a:link { color: rgb(0, 0, 255); }En este trabajo se presenta una contribución para el uso de dispositivos móviles, con recarga de acumulador basada en energía solar fotovoltaica, en zonas aisladas que se encuentren fuera del alcance de los centros de distribución de energía.  En primer lugar, se determinó la potencia utilizada por aplicaciones móviles para ejecutar tareas de uso frecuente en zonas rurales. Luego, en función de valores de radiación solar de referencia y sin recurrir a baterías externas,se calculó la energía  que un pico sistema fotovoltaico le puede entregar a un dispositivo móvil. Finalmente, se agruparon las aplicaciones en perfiles y se verificó que el sistema fotovoltaico sea capaz de satisfacer los requerimientos de energía de cada perfil. La propuesta posibilitará por una parte, optimizar elconsumo del dispositivo, y por otra la construcción de un cargador solar de tamaño y peso reducido que se ajuste a los requerimientos energéticos del perfil de aplicaciones utilizadas en una zona rural.","palabras_clave":"Dispositivos móviles|consumo de energía|zonas rurales|energía solar fotovoltaica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":9063,"idioma_id":4,"titulo":"Numerical simulacion of austepering heat treatment of a ductile cast iron","resumen":"This paper presents a coupled thermo-mechanical-metallurgical formulation to predict the dimensional changes and microstructure of a ductile cast iron part as a consequence of an austempering heat process. To take into account the different complex phenomena which are present in the process, the stress-strain law and plastic evolution equations are defined within the context of the associate rate-independent thermo-plasticity theory. The metallurgical model considers the reverse eutectoid, ausferritic, and martensitic transformations using macro- and micro-models. The resulting model is solved using the finite element method. The performance of this model is evaluated by comparison with experimental results of a dilatometric test. The results indicate that both the experimental evolution of deformation and temperature are well represented by the numerical model.","palabras_clave":"AUSTEMPERED DUCTILE IRON|NUMERICAL SIMULATION|FINITE ELEMENT|PHASE CHANGE|DIMENSIONAL CHANGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":9119,"idioma_id":5,"titulo":"Las lógicas del archivo hacen la historia: las fuentes de la policía y de la Compañía de Jesús en el Archivo General de la Nación","resumen":"Un conjunto de fuentes de la policía y la Compañía de Jesús nos permite confirmar que la narrativa histórica sigue a la forma en que éstas se organizaron. En el caso de la policía, existe una conexión inmediata entre el conocimiento y el volumen de las fuentes. El gran número de documentos en el AGN en la década de 1820 se debe a la penetración de un nuevo conocimiento, con el fin de crear un estado. El retorno a un gobierno local en 1829, en tanto, muestra una cultura judicial que aún queda en el marco de un mundo sin Estado.Los documentos jesuitas, generados para controlar la actividad de sus miembros, terminaron siendo un éxito en un contexto diferente, porque proporcionaron una descripción detallada del mundo rural. La coherencia de origen de estos documentos permitió que los historiadores hayan estado durante décadas aprovechando su valor para generar nuevos saberes.","palabras_clave":"Archivos|Historia|Fuentes|Lógica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":9162,"idioma_id":4,"titulo":"Isolation of a Seawater Tolerant Leptospira spp. from a Southern Right Whale (Eubalaena australis)","resumen":"Leptospirosis is the most widespread zoonotic disease in the world. It is caused by pathogenic spirochetes of the genus Leptospira spp. and is maintained in nature through chronic renal infection of carrier animals. Rodents and other small mammals are the main reservoirs. Information on leptospirosis in marine mammals is scarce; however, cases of leptospirosis have been documented in pinniped populations from the Pacific coast of North America from southern California to British Columbia. We report the isolation of a Leptospira spp. strain, here named Manara, from a kidney sample obtained from a Southern Right Whale (Eubalaena australis) calf, which stranded dead in Playa Manara, Península Valdés, Argentina. This strain showed motility and morphology typical of the genus Leptospira spp. under dark-field microscopy; and grew in Ellinghausen-McCullough-Johnson-Harris (EMJH) medium and Fletcher medium after 90 days of incubation at 28°C. Considering the source of this bacterium, we tested its ability to grow in Fletcher medium diluted with seawater at different percentages (1%, 3%, 5%, 7% and 10% v\/v). Bacterial growth was detected 48 h after inoculation of Fletcher medium supplemented with 5% sea water, demonstrating the halophilic nature of the strain Manara. Phylogenetic analysis of 16S rRNA gene sequences placed this novel strain within the radiation of the pathogenic species of the genus Leptospira spp., with sequence similarities within the range 97-100%, and closely related to L. interrogans. Two different PCR protocols targeting genus-specific pathogenic genes (G1-G2, B64I-B64II and LigB) gave positive results, which indicates that the strain Manara is likely pathogenic. Further studies are needed to confirm this possibility as well as determine its serogroup. These results could modify our understanding of the epidemiology of this zoonosis. Until now, the resistance and ability to grow in seawater for long periods of time had been proven for the strain Muggia of L. biflexa, a saprophytic species. To the best of our knowledge, this is the first isolation of a Leptospira sp. from cetaceans. Our phenotypic data indicate that strain Manara represents a novel species of the genus Leptospira, for which the name Leptospira brihuegai sp. nov. is proposed.","palabras_clave":"EUBALAENA AUSTRALIS|LEPTOSPIRA SPP.|ISOLATION|HALOPHILIC BACTERIA|WILDLIFE|SOUTHERN RIGHT WHALE|PENINSULA VALDES|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":9223,"idioma_id":5,"titulo":"Mapas, planes y esquemas en la construcción del Gran Buenos Aires","resumen":"A lo largo del siglo XX e inicios del siglo XXI, el Gran Buenos Aires fue objeto de variadas representaciones gráficas, desde detallados mapas topográficos hasta esquemas propositivos. ¿Qué relaciones se establecieron entre los mapas y los esquemas de los planes urbanísticos formulados para la región metropolitana de Buenos Aires durante ese periodo? Según planteamos, las tensiones que se dirimen entre la 'ciudad existente' -tal como se presenta en las bases cartográficas- y la 'ciudad proyectada' -que resulta de los esquemas interpretativos y propositivos-, muestran que las imágenes, signadas por tecnologías, debates y métodos en transformación, construyen diferentes formas de mirar. Para tratar esa problemática, sin pretender una historia de larga duración ni un compendio, este artículo propone un recorrido exploratorio por cuatro puntos de inflexión que consideramos ilustrativos del proceso de construcción de la imagen del Gran Buenos Aires.","palabras_clave":"GRAN BUENOS AIRES|CARTOGRAFIA|PLANIFICACION URBANA|HISTORIA URBANA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":9487,"idioma_id":5,"titulo":"Entre el malón, el comercio y la diplomacia: dinámicas de la política indígena en las fronteras pampeanas (siglos XVIII y XIX)","resumen":"El artículo se propone historizar la imagen de la conflictividad asociada a la práctica del malón indígena en la larga duración de la Frontera Sur con las pampas y norpatagonia, realizando un balance crítico acerca de las articulaciones entre comercio regional de ganado, el proceso de 'araucanización' y la acción malonera. El foco está centrado en el papel de la diplomacia y los tratados de paz con base en la percepción de raciones como una dimensión significativa para la comprensión de la espacialidad que asume la conflictividad fronteriza en el siglo XIX. Los malones y la diplomacia se presentan como vías alternativas a las que los cacicatos de territorialidad pampeana recurrieron para sostener su ubicación geopolítica e insertarse simultáneamente en dos circuitos comerciales y políticos interconectados: el que los vinculaba a las localidades y agentes de la sociedad estatal en la Frontera Sur y el que los articulaba económica, política y parentalmente a las parcialidades pampeanas, patagónicas y transcordilleranas.","palabras_clave":"MALONES|FRONTERA SUR|COMERCIO|DIPLOMACIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":9643,"idioma_id":4,"titulo":"Effect of Na+ ion on the dissolution of ferrocolumbite in autoclave","resumen":"The effect of different leaching media on the dissolution of ferrocolumbite from the province of San Luis, Argentina, in an autoclave was investigated. The leaching agents used were aqueous solutions of HF?NaF or HF?Na2C2O4.The researched parameters were temperature and different types and concentrations of the leaching media. The obtained results showthat the values of Nb and Ta extractions from ferrocolumbite with diluted HF are substantially modified when NaF or Na2C2O4 are added to the leaching medium, and separation of Ta from the other components present in the sample is successfully accomplished while working under certain conditions of temperature and reagent concentrations.","palabras_clave":"Na+|Na2C2O4|NaF|FERROCOLUMBITE|DISSOLUTION|AUTOCLAVE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":9817,"idioma_id":5,"titulo":"Investigar desde y para la educación física.Producciones de un proyecto de investigación","resumen":"Ajustar las investigaciones desde y para la educación física a la formalidad de la academia deviene un desafío, no sólo porque la educación física universitaria se ha demorado (por distintas razones) en asumir la responsabilidad de investigar, sino porque la definición y alcances del campo se juegan en las decisiones que los equipos de investigación van tomando.La investigación se inscribe en el paradigma interpretativo y tiene por objetivo conocer y comprender las relaciones entre la formación docente y el ejercicio profesional del docente de Educación Física. Se propone una triangulación intrametodológica, articulando entrevistas en profundidad a docentes seleccionados por muestreo teórico, y análisis de normativa vigente sobre el ejercicio profesional; plan de estudios y programas de la formación docente. Se obtuvieron cuatro resultados que puestos a discutir dan lugar a la siguiente conclusión: el campo laboral del profesor de educación física se presenta en continuo crecimiento y movimiento, cuestión que coloca a los profesionales en el desafío de asumir la formación permanente, la investigación-acción y el encuentro con colegas como herramientas necesarias para ofrecer una educación de calidad. La formación de grado debe potenciar el tratamiento de estas herramientas.Este artículo condensa algunas producciones que, más allá de los resultados formalmente obtenidos en el proceso de investigación, surgieron a partir de la maduración de las tareas descriptas en el proyecto y del posicionamiento sostenido.","palabras_clave":"INVESTIGACIÓN|EDUCACIÓN FÍSICA|DESAFIOS|DECISIONES|PRODUCCIONES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":9829,"idioma_id":5,"titulo":"Un método de optimización proximal al problema de anidamiento  de piezas irregulares utilizando arquitecturas en paralelo","resumen":"Se presenta un modelo discreto que resuelve el problema bidimensional de corte y ubicación, generalmente llamado nesting (anidamiento), de gran interés en las industrias textiles. El problema consiste en minimizar el remanente o desperdicio de un material a través de la ordenación de moldes geométricamente irregulares. Como solución se propone un algoritmo heurístico polinomial, flexible porque permite evaluar distintas condiciones y restricciones del problema, y paralelizable en arquitecturas de múltiples núcleos de bajo costo. La metodología propuesta se evaluó con casos de estudio de la literatura del área y se comparan los tiempos de cómputo con una herramienta comercial del sector, obteniéndose muy buenos resultados. Además, se logra una aceleración del procesamiento de hasta 4X   con respecto a la versión secuencial.","palabras_clave":"Optimización|Corte, industria textil, .|heurística|Paralelización"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":9940,"idioma_id":4,"titulo":"Small-sized abelisaurid (Theropoda: Ceratosauria) remains from the Upper Cretaceous of northwest Patagonia, Argentina","resumen":"A new abelisaurid theropod from the Cenomanian of Candeleros Formation (Neuquén Province, NW Patagonia, Argentina) is described. It includes an isolated frontal, partial pelvis, two fused sacral centra,femoral shaft, rib fragments, partial metatarsal II and shaft of metatarsal III. A paleohistological analysis shows that MMCh-PV 69 was somatically mature at time of death. The prevalence of relatively ordered intrinsic fibers in the primary bone indicates a relatively lower growth rate of MMCh-PV 69 compared with other abelisauroids, such as Aucasaurus garridoi. Phylogenetic analysis found MMCh-PV 69 as a basal abelisaurid, sister group of the node formed by Majungasaurinae and Brachyrostra. We estimated the body mass of MMCh-PV 69 in 240 kg, which makes it one of the smallest abelisaurids recorded. This new form adds to the extensive theropod fauna of the Candeleros Formation, probably the most diverse association of meat-eating dinosaurs recorded in a Cretaceous Formation from South America.","palabras_clave":"Abelisauridae |Patagonia |Cretaceous |Candeleros Formation |Paleohistology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10068,"idioma_id":5,"titulo":"La Ciudad desde la ventana de la acción colectiva","resumen":"Este artículo invitaa mirar la ciudad desde la ventana de la acción colectiva. Ventana de múltiplesaristas, con trasparencias y, también, opacidades; siempre abierta alcuestionamiento y la proposición. ¿Cómo caracterizar el escenario deinteracción de las organizaciones sociales en el espacio local? ¿Cuáles son susprincipales objetivos? ¿Se inscriben en algún proyecto político? ¿Quérelaciones establecen entre ellas y con el territorio? Éstas son algunas de laspreguntas que delinearon el itinerario del artículo que aquí compartimos y nosanimaron en la iniciativa de construir una ?cartografía? de las organizacionessocio-territoriales y socio-políticas de la ciudad de Río Cuarto (Argentina) enel período 2014-2015.La presente propuesta se inscribe en el marco de un proyecto deinvestigación más amplio, e intenta difundir algunos de sus resultadosparciales. En un primer apartado del texto se exponen algunas precisionesteóricas sobre la problemática general de la acción colectiva. En un segundomomento, se exponen algunasconsideraciones metodológicas y posibles contribuciones. Finalmente, se hacereferencia a la sistematización propuesta para aprehender parte del complejoescenario de los actores colectivos de la ciudad. Ello se presenta como unmapeo abierto, en permanente revisión eincorporación de nuevas categorías.","palabras_clave":"organizaciones socio-políticas| organizaciones socio-territoriale|ciudad"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10169,"idioma_id":4,"titulo":"Occurrence of Phomopsis sp. causing cankers on pecan trees in Buenos Aires province, Argentina","resumen":"oduction of pecan (Carya illinoiensis) continues to increase in Argentina, due mainly to its nutritional qualities and sustained export demand. In April 2014, the presence of cankers on branches and twigs was observed on pecan trees in the province of Buenos Aires, where the incidence ranged from 10 to 50% of the surveyed plantations (Fig. 1). Fungal isolates with morphological characteristics similar to those of Phomopsis (Sutton, 1980) were collected from cankers on potato dextrose agar after seven days of incubation in a growth chamber at 25°C with a 12 h photoperiod. Colonies in their early stages were whitish cottony (Fig. 2). They contained numerous, globose, brown to black pycnidia of 346.1 ± 59.8 µm × 286.4 ± 55.6 µm (Fig. 3), alpha hyaline conidia, fusiform to ellipsoid in shape, bigutulate with an average size of 6.8 ± 1.0 µm × 2.0 ± 0.2 µm, and beta filiform hyaline conidia, hamate in shape with average size of 21.6 ± 3.9 µm × 1.0 ± 0.1 µm.Nucleic acid was extracted using a Promega Wizard genomic DNA purification kit (Madison, WI, USA) and the ITS region was amplified using the universal primers ITS4 and ITS5. The resulting sequence of 950 bp (GenBank Accession No. KU359781) was compared to other sequences and was most similar to Diaporthe middletonii (KJ197286, 99%), D. beilharziae (GQ250220, 98%), D. acaciarum (KP004460, 98%), D. infecunda (KC343132, 98%) and D. sackstonii (KJ197287, 97%). However, the biological and morphological characters of the Diaporthe colonies isolated from pecan were most similar to the Phomopsis anamorphic state of D. infecunda (Gomes et al., 2013). It seems likely the isolated fungus belongs to a species of Phomopsis not previously recorded on pecan. To confirm the pathogenicity of the isolates, the toothpick inoculation method was used. The inoculum was introduced into branches and twigs of pecan plants through a small incision made with a scalpel. Plants were covered with a plastic film and incubated in a growth chamber at 25ºC for 30 days. Typical disease symptoms were observed 25 days after inoculation on branches and the inoculated pathogen was re-isolated, thus confirming pathogenicity to pecan and fulfilling Koch?s postulates. The culture has been deposited at the La Plata Spegazzini Colección de Cultivos Argentina (Accession number 1219).In Argentina, the Phomopsis genus has been reported previously on pecan nuts (Comerio, 2007). In this case, we report Phomopsis sp., anamorphic state of Diaporthe, as the causative agent of cankers on pecan for the first time in Argentina. Further studies will be necessary to fully resolve the taxonomy of Phomopsis sp. associated with cankers on pecan.","palabras_clave":"PECAN|PHOMOPSIS|CANKER|BRANCHES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10180,"idioma_id":4,"titulo":"Conceptual Model-Based Optimization and Environmental Evaluation of Waste Solvent Technologies: Distillation\/Incineration versus Distillation\/Pervaporation","resumen":"In this work, a conceptual model-based optimization is performed for designing two waste solvent treatment technologies: i) hybrid process distillation assisted by pervaporation and ii) distillation\/incineration.This task was performed resorting to conceptual models or shortcuts for each unit operation involved, which are characterized by their abilities to capture the essence of the process at a low computational cost. Life cycle assessment (LCA) was applied to evaluate the environmental impact of both alternatives. Optimal values for the utilities, i.e., cooling water, electricity and steam needed for distillation and pervaporation were used as the input data to perform the environmental analysis with LCA. Ecosolvent v.1.0.1 was used to calculate inventories data related to the incineration technology (waste solvent incineration and cement kiln) of the first cut of the distillation step for the case distillation\/incineration and for treatment of column residues of both alternatives investigated.Applied to the mixture isopropyl alcohol-water, optimal values for per-pass IPA recovery and distillate composition were determined for the alternative distillation\/incineration and distillation\/pervaporation, respectively. From the analysis of the economic figures, it was concluded that solvent recovery through the hybrid process is the better option mainly due to the savings in the cost of fresh solvent. The LCA results, performed in SimaPro 7.3, show that the main impact is related to the solvent production. Thus, solvent recovery is the best option if minimization of the use of resources is paramount. Nevertheless incineration in a cement kiln becomes relevant in terms of human health for the avoided use of fuels.Furthermore, it was concluded that both process optimization with the aid of conceptual models and LCA are key tools in the decision-making process to determine which technology is the most appropriate for the treatment of waste solvents.","palabras_clave":"Destilación\/Incineración|Destilacion\/Pervaporación|Optimización|LCA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10308,"idioma_id":5,"titulo":"Urbanizando la ornitología (revisión de libro)","resumen":"-","palabras_clave":"-"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10434,"idioma_id":4,"titulo":"A Comparative Study of Spray-Dried Medicinal Plant Aqueous Extracts. Drying Performance and Product Quality","resumen":"In the manufacture of herbal medicinal tablets, dried plant extracts are employed as the therapeuticingredient. These powders, usually obtained by spray drying, are typically hygroscopic and possess poorflow and compactability for the manufacture of tablets by direct compression (DC). Besides, spray-dryingoperating conditions and liquid feed composition are reported to be dependent on the herbal medicine.Consequently, the production of dried extracts implies long new product development times. Therefore, thegoal of this paper was to: a) provide recommendations as initial production point of herbal powders suitablefor DC by spray drying and b) study the powder properties to identify those that are affected by the extractnature. Particularly, a unique set of operating conditions was found to be appropriate to produce powders ofseven different medicinal plant extracts. In fact, all the spray-dried products showed adequate flowability,stability and compactability.Powders properties, as particle size and morphology, moisture content, hygroscopicity, flowability andcompact hardness were not a function of the type of herb. Conversely, the process yield and glass transitiontemperature, particle and bulk densities, powder composition, compact porosity, wetting and disintegrationtimes were found to be dependent on the chemical nature of the herbs.","palabras_clave":"SPRAY DRYING|HERBAL MEDICINAL EXTRACTS| TABLETS|DIRECT COMPRESSION."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10455,"idioma_id":4,"titulo":"New rebbachisaurid cranial remains (Sauropoda, Diplodocoidea) from the Cretaceous of Patagonia, Argentina, and the first endocranial description for a South American representative of the clade","resumen":"Here we report new rebbachisaurid material (MMCh-PV 71) recovered from the Candeleros Formation (Cenomanian) of northwest Patagonia, Argentina. The cranial remains consist of a partial braincase and a right quadrate. Fractures in the braincase exposed the endocranial cavity, allowing the first study of the brain and inner ear morphologies of a South American rebbachisaurid. The braincase and cranial endocast both exhibit traits similar to those observed in the Cretaceous rebbachisaurs Nigersaurus from Africa and Limaysaurus from Argentina, although in terms of osteology, the South American taxa are highly similar. The endocast of MMCh-PV 71 is more similar to that of Nigersaurus than to those of Diplodocus and Camarasaurus, suggesting some probable rebbachisaurid features such as the noteworthy presence of the flocculus. The overall morphology of the quadrate shows similarities with Limaysaurus and Nigersaurus. However, differences such as the broader posterior fossa and the shape and orientation of the head and the pterygoid process indicate that the new specimen could represent a distinct taxon.","palabras_clave":"CRANIAL ENDOCAST|INNER EAR|BRAINCASE|REBBACHISAURIDAE|SOUTH AMERICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10547,"idioma_id":5,"titulo":"Patriotismo y democracia. Revisión teórica de un concepto polémico.","resumen":"La persistente apelación a las nociones de patria y patriotismo en las democracias sudamericanas contrasta con la suspicacia de la teoría política, que insiste en el carácter anacrónico y peligroso de estos términos. Ante esto, se propone una revista del concepto de patriotismo, orientada a identificar tres concepciones preeminentes: el patriotismo como orgullo nacional, como orgullo republicano y como compasión por el prójimo. Tras restituir estas tres concepciones, se propone una reflexión sobre el lugar del patriotismo en la teoría política.","palabras_clave":"patrotismo|democracia|nación|república|compasión"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10557,"idioma_id":4,"titulo":"A new milk-clotthing enzyme produced by Bacillus sp. P45 applied in cream cheese development","resumen":"The reduction on the supply of natural coagulant led to a growing demand for rennet substitutes, promoting a search for new sources of proteases with coagulant properties. The aim of this study was to investigate the application of the proteolytic enzyme as a novel milk-clotting protease in the development of cream cheese enriched with chia and quinoa flour. At a concentration of 30 mg\/mL, the milk-clotting strength was similar to that observed for commercial chymosin, demonstrating the new enzyme´s ability to catalyze the hydrolysis of milk casein. The cheese developed showed high water retention (&#8805;99.0%) and low syneresis values (&#8804;0.72%). The results indicate that the product made using the enzyme showed adequate sanitary conditions and technological characteristics indicated that the product is highly stable and viable.","palabras_clave":"KERATINASE|PROTEASES|CHIA |QUINOA|CREAM CHEESE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10614,"idioma_id":5,"titulo":"Actitudes y prácticas sexuales de los jóvenes escolarizados en el nivel medio de la enseñanza pública argentina ¿nuevos patrones?","resumen":"Revista arbitrada: SíÍndices y resúmenes?Iresie (Indice de Revistas de Educación Superior e Investigación Educativa)?Latindex-Catálogo?Latindex-DirectorioA través de este artículo se analizan los cambios ocurridos en los últimos siete años en las prácticas sexuales y en las actitudes relativas al género y a las sexualidades no hegemónicas de jóvenes que asisten a la escuela media en la Argentina. Para este fin se toman en cuenta los resultados obtenidos en dos investigaciones realizadas en 2005 y 2012, con muestras de alrededor de 6.000 jóvenes cada una, de alumnos de escuelas públicas de todas las regiones del país. Los datos fueron analizados de acuerdo al sexo, a la edad, al nivel socioeconómico y a la región del país donde residían los encuestados. El instrumento de recolección de datos consistió en una encuesta autoadministrada. En relación a las diversidades sexuales, los resultados muestran un aumento de la aceptación de las minorías sexuales. En torno a las prácticas sexuales de los jóvenes, se observa un corrimiento de la edad de inicio hacia edades menores. Respecto de la utilización de métodos anticonceptivos [MACs], existe un leve descenso en la utilización del preservativo masculino como método predominante de cuidado, así como un aumento importante en la utilización de pastillas anticonceptivas. Un hallazgo importante reside en el aumento de la utilización de la anticoncepción de emergencia.","palabras_clave":"PRACTICAS SEXUALES|ADOLESCENTES|PRÁCTICAS DE CUIDADO|MÉTODOS ANTICONCEPTIVOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10628,"idioma_id":5,"titulo":"Ramulispora sorghi patógeno en cultivos de sorgo del NE de Argentina","resumen":"Durante el año 2012 y 2013 en monitoreos del estado sanitario de cultivos de sorgo (S. bicolor), en el centro sur de la provincia de Corrientes, se observaron lotes de sorgo granífero (cultivar DK 61T), presentando lesiones necróticas en toda el área foliar e inclusive las vainas foliares, muy semejantes a las del tizón causado por Exserohilum turcicum); asimismo en muestras de hojas enfermas procedentes del departamento Villa Angela (Chaco), se observó similar sintomatología: manchas castaño claro, elípticas, elongadas, márgenes púrpura, rodeadas por prominente halo clorótico, de 2 a 15 cm de largo; las lesiones se pueden unir causando severo atizonamiento. El exámen de síntomas y signos, y pruebas de patogenicidad realizadas permitieron concluir que el agente causal de tales síntomas es Ramulispora sorghi.","palabras_clave":"Etiologia|Micosis|Sorghum"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10825,"idioma_id":4,"titulo":"Uncultivated margins are source of soil microbial diversity in an agricultural landscape","resumen":"Agricultural intensification simplified environments, reduced their diversity, and hindered theirecosystem processes. Permanently vegetated areas (uncultivated margins) embedded in the cultivatedmatrix play a critical role in maintaining diversity and soil properties, and so mitigate the negative impactof intensification. We performed two studies aimed at evaluating the role of uncultivated margins on soilheterotrophic bacteria. In the first study, we sampled soybean fields and herbaceous and woody marginsin three locations along a 100-kilometer transect. In a second study, in one location we sampleduncultivated margins and perpendicular 50-meter transects from each margin towards the centre of itsadjacent soybean field. As control, we sampled similar transects in soybean fields that had cropped fieldsas margins. In both studies, we characterized the catabolic profiles and diversity of the heterotrophicbacterial community and soil properties. Soil microbial communities of uncultivated margins differed incomposition and were more diverse than the cropped matrix. In turn, these differences positivelycorrelated with soil pH. Woody margins also influenced the soil microbial composition, diversity and soilpH of neighbouring cultivated fields. In contrast, herbaceous margins did not influence their cultivatedneighbours. These results broaden our understanding of soil heterotrophic bacterial community in agroecosystemsand its implications for ecosystem functioning.","palabras_clave":"microorganismos|suelo|diversidad|agricultura"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10826,"idioma_id":5,"titulo":"El malestar de una cultura política. La 'Izquierda Nacional' de Jorge Abelardo Ramos ante el frondicismo","resumen":"La campaña presidencial y el posterior gobierno de Arturo Frondizi fueron un polo de adhesión y reclutamiento de varias figuras y grupos de las culturas de izquierdas en Argentina, pero también motivo de enfrentamiento y disputa, como revela el caso de la 'Izquierda Nacional' liderada por Jorge Abelardo Ramos. El triunfo de lo que fue conocido como el frondicismo generó una toma de partido en la vida ideológica y política por parte de Ramos y su grupo, en un contexto en que la figura y el proyecto de Frondizi concitaban un creciente interés y apoyo por parte de un sector de la izquierda intelectual y juvenil pero también del peronismo. El análisis de la intervención del grupo de Ramos en torno al frondicismo no solo permite reconstruir un momento significativo pero poco conocido de la historia de la 'Izquierda Nacional' en el país, sino también trazar el estado de sensibilidad que atravesó a la izquierda argentina a fines de la década de 1950.","palabras_clave":"Cultura Politica|Izquierda |Frondicismo|Intelectuales políticos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10877,"idioma_id":4,"titulo":"Embedded beam element with interaction surface for lateral loading of piles","resumen":"This paper presents a numerical formulation of a three dimensional embedded beam element which incorporates an explicit interaction surface between soil and pile. The formulation is herein implemented for lateral loading of piles, but is able to represent soil-pile interaction phenomena in a general manner for different types of loading conditions or ground movements. The model assumes perfect adherence between beam and soil along the interaction surface. The paper presents a comparison of the results obtained by means of the present formulation and by means of a previously formulated embedded pile element without interaction surface, as well as reference semi-analytical solutions and a fully 3D FE model. It is seen that the proposed embedded element provides a better convergence behavior than a previously formulated embedded element, and is able to reproduce key features of a full 3D FE model.","palabras_clave":"embedded beam|finite element|lateral loading|soil?pile interaction"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":10980,"idioma_id":4,"titulo":"Sperm Release From the Oviductal Epithelium Depends on Ca(2+) Influx Upon Activation of CB1 and TRPV1 by Anandamide.","resumen":"The oviduct acts as a functional sperm reservoir in many mammalian species. Both binding and release of spermatozoa from the oviductal epithelium are mainly modulated by sperm capacitation. Several molecules from oviductal fluid are involved in the regulation of sperm function. Anandamide is a lipid mediator involved in reproductive physiology. Previously, we demonstrated that anandamide, through activation of the cannabinoid receptor type 1 (CB1), promotes sperm release from bovine oviductal epithelial cells, and through CB1 and the transient receptor potential vanilloid 1 (TRPV1), induces sperm capacitation. Herein we investigate co-activation between CB1 and TRPV1, and Ca2+ influx as part of the mechanism of action of anandamide during sperm release from oviductal cells. Our results indicate that in the absence of Ca2+ anandamide failed to release spermatozoa from oviductal epithelial cells. Additionally, sperm release promoted by cannabinoid and vanilloid agonists was abolished when the spermatozoa were preloaded with BAPTA-AM, a Ca2+ chelator. We also determined Ca2+ levels in spermatozoa preloaded with FURA2-AM co-cultured with oviductal cells and incubated with different cannabinoid and vanilloidagonists. The incubation with different agonists induced Ca2+ influx, which was abolished by CB1 or TRPV1 antagonists. Our results also suggest that a phospholypase C (PLC) might mediate the activation of CB1 and TRPV1 in sperm release from the bovine oviduct.Therefore, our findings indicate that anandamide, through CB1 and TRPV1 activation, is involved in sperm release from the oviductal reservoir. An increase of sperm Ca2+ levels and the PLC activation might be involved in anandamide signaling pathway.","palabras_clave":"SPERM|OVIDUCT|ENDOCANNABINOID"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":11043,"idioma_id":5,"titulo":"Actualización de la distribución de tábanos (Diptera: Tabanidae) en la reserva natural Esteros del Iberá","resumen":"Se registran por primera vez cinco especies de tábanos (Diptera:  Tabanidae) en la reserva natural de los Esteros del Iberá. Chrysops flavoscutellatus  Kröber, 1926, Fidena sorbens (Wiedemann, 1828), Phaeotabanus fervens  (Linnaeus, 1758), Poeciloderas seclusus (Brèthes, 1910) y Tabanus  pungens Wiedemann, 1828","palabras_clave":"CAPITA MINI|DISTRIBUCION|SAN JUAN PORIAHU"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":11106,"idioma_id":5,"titulo":"América Latina y los movimientos estudiantiles: el caso chileno","resumen":"En distintos momentos de su historia política, América Latina ha experimentado la emergencia de movimientos estudiantiles agotados por la inacción de los sistemas políticos y económicos de los Estados nacionales que no atienden sus necesidades postergadas. Dichos movimientos se unen a partir de intereses comunes con el objetivo de cambiar sus realidades y provocar un giro en la lógica institucional imperante. A pesar de que la región ha logrado cierta estabilidad institucional persisten algunas paradojas en su devenir histórico, sobre todo porque gran parte de sus países llegó al Bicentenario presentando índices de crecimiento aceptables que de alguna forma permitieron enfrentar la celebración con relativa calma. Sin embargo, la pobreza, la desigualdad social y la inequitativa distribución de la riqueza siguen estando presentes y no podrán ser resueltas en el mediano plazo, y no por falta de voluntad política para su concreción, sino porque la región no está preparada para dar el salto definitivo al tan esperado desarrollo.En esta línea argumentativa, agregamos que los países latino-americanos han sido absorbidos por paradojas que son más visibles de lo que se piensa, pero que a lo largo del tiempo han estado ocultas por influjo de fuerzas exógenas que se niegan a verlas. El presente trabajo pretende mostrar que, pese a ser un espacio relativamen-te independiente, América Latina está en un proceso de búsqueda de su propia identidad en el que el sector estudiantil desempeña una función trascendental para comprender su devenir histórico. En el binomio entre lo hegemónico y lo contrahegemónico que da lugar a la historia, las fuerzas exógenas a las que antes hemos hecho mención pueden ser concebidas como posiciones impuestas y reglamentadas de lo que es correcto para la orientación de una sociedaddeterminada. Algo así como la imposición del saber, como sostieneMignolo al afirmar que ?la metáfora de sistema-mundo modernodeja en la oscuridad la colonialidad del poder (Quijano 1997) y ladiferencia colonial (Mignolo 1999, 2000). En consecuencia, sóloconcibe el sistema-mundo moderno desde su propio imaginario,pero no desde el imaginario conflictivo que surge con y desde ladiferencia colonial?.1 Bajo este marco de interpretación crítica,tanto en lo social como en lo político, normalmente los estudiantesse debaten entre su pasado y su presente con el objetivo de proponerun futuro promisorio para ellos y para las generaciones veniderasy, en algunos casos, se asumen como herederos de las políticasestatales que no cumplen sus expectativas. No puede decirse queeste proceso ha sido lineal y sin obstáculos en el camino. Por elcontrario, la existencia de problemáticas irresueltas por los distintosgobiernos ha ocasionado el surgimiento de movimientos socialesvinculados a este factor, en el entendido de que los actores que handesarrollado una comprensión más profunda de su función en lasociedad han empujado al Estado a recoger y escuchar demandaspostergadas por un largo tiempo.Con el objetivo de construir su propia historia, y en algunos casosde superarla, América Latina rompió con la tradición de subordinarsea los intereses de los países centrales posibilitando la idea deque la región se constituya en un espacio de futuro y se aleje de la matriz de resistencia permanente que la ha caracterizado. En dichos episodios de resistencia los movimientos sociales y los signos de acción colectiva han sido clave en los procesos reivindicativos originados dentro de la sociedad civil.En este escenario, entre 2006 y 2011 Chile también vivióprocesos de convulsión política con la llamada ?Revolución Pingüina?que logró instalar el debate acerca de un nuevo modeloeducacional para el país. Dicha revolución se produjo al inicio delprimer mandato de Michelle Bachelet (2006-2010) y se caracterizópor manifestaciones de estudiantes secundarios congregadosen torno a la exigencia de una educación pública y gratuita paratodos y a la crítica de reformas educacionales que comenzaron aimplementarse durante la dictadura militar chilena (1973-1990) yque se continuaron durante los gobiernos de la Concertación (1990-2006). La gestación del movimiento no comenzó precisamente enaquellos años pero se nutrió de experiencias similares que en sumomento no lograron la visibilidad ni la fuerza de este último. Ental sentido, la Revolución Pingüina fue ?un movimiento políticoque ha hecho públicos los cuestionamientos al modelo neoliberaly ha puesto como eje central la preocupación por la inequidad delsistema educativo?.","palabras_clave":"movimientos sociales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":11310,"idioma_id":5,"titulo":"El derecho del niño a ser oído en la justicia de familia. Prácticas, sentidos y valoraciones","resumen":"En este artículo se presentan los resultados de la investigación 'El derecho del Niño a ser Oído en la justicia de familia' desarrollada durante octubre de 2014 a septiembre de 2015, cuyo objetivo principal fue conocer y analizar las prácticascotidianas de la justicia de familia en el modo de interpretar y materializar los derechos de los niños, niñas y adolescentes a ser oídos y a que su opinión sea tenida primordialmente en cuenta en todo procedimiento judicial y administrativo que los afecte.","palabras_clave":"NIÑEZ|JUSTICIA DE FAMILIA|ABOGADO DEL NIÑO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":11332,"idioma_id":5,"titulo":"Valoración de características nucleares en muestras citológicas de tumores mamarios caninos","resumen":"El presente trabajo tuvo como objetivo comprobar la utilidad y el valor predictivo de la determinación de características morfológicas nucleares subjetivas y objetivas, en muestras citológicas de tumores mamarios caninos. Se estudiaron muestras de 34 pacientes, las cuales fueron controladas hasta 18 meses post cirugía, lo que permitió la confección de curvas de supervivencia. Se realizó la estadificación clínica al momento de la consulta, el citodiagnóstico y la determinación del grado nuclear de las muestras obtenidas por punción y coloreadas con hematoxilina y eosina. Para las mediciones se utilizó el programa Leica Application Suite 3.4.1., calculándose el diámetro nuclear promedio, áreanuclear promedio, perímetro nuclear promedio e índice de redondez, todos ellos parámetros cariométricos de valor pronóstico en medicina humana. Los resultados señalaron un aumento gradual de los valores morfométricos de cada parámetro, coincidentes con el aumento de la graduación nuclear, del estadio clínico, así como de los tipos histopatológicos considerados de peor pronóstico. Las curvas de supervivencia mostraron diferencias significativas al comparar los grados nucleares. Los hallazgos efectuados respaldan la cualidad predictiva de estas herramientas diagnósticas.","palabras_clave":"citodiagnóstico|pronóstico|tumores mamarios caninos|graduación nuclear"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":11582,"idioma_id":4,"titulo":"A PENCIL-LEAD BISMUTH FILM ELECTRODE AND CHEMOMETRICS TOOLS FOR SIMULTANEOUS DETERMINATION OF HEAVY METALS IN PROPOLIS SAMPLES.","resumen":"A simultaneous determination of Zn, Cd, Pb and Cu in raw propolis samples, employing square wave anodic stripping voltammetry and chemometric tools, was developed. For this purpose, a pencil-lead bismuth &#64257;lm electrode was used as a working electrode . In order to optimize the parameters of square wave voltammetry a Box Behnken design combined with desirability function was used . Different algorithms such Asymmetric Least Squares (AsLS) and Correlation Optimized Warping (COW) were employed in order to preprocess the raw data. Partial Least Squares (PLS) and Arti&#64257;cial Neuron Networks (ANN) were used to predict the concentration of the four metals in the samples. The method was tested successfully on raw propolis samples obtained from different localities of the Province of Buenos Aires, Argentina and the results were validated with recovery assays.","palabras_clave":"PENCIL-LEAD |PROPOLIS|BISMUTH |ELECTRODE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":11608,"idioma_id":4,"titulo":"Quantum Mechanical Model for Plasmon Excitations in Nanostructures","resumen":"Quantum Mechanical Model for Plasmon Excitations in Nanostructures,         J. A. García Gallardo, J. L. Gervasoni,       Plasmonics, Volume 10, Issue 4, pp 941-947 (2015).","palabras_clave":"PLASMON|EXCITATION|NANOPERTICLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":11656,"idioma_id":4,"titulo":"Assessment of SAR speckle filters in the context of object-based image analysis","resumen":"The initial step in most object-based classification methodologies is the application of a segmentation algorithm to define objects. In the context of synthetic aperture radar (SAR) image analysis, the presence of speckle noise might hamper the segmentation quality. The aim of this study is to assess the segmentation performance of SAR images when no filter or different filters are applied before segmentation. In particular, the performance of the mean-shift segmentation algorithm combined with different adaptive and non-adaptive filters is assessed based on both synthetic and natural SAR images. Studied filters include the non-adaptive Boxcar filter and four adaptive filters: the well-known Refined Lee filter and three recently proposed non-local filters differing, in particular, in their dissimilarity criteria: the Hellinger and the Kullback?Leibler filters are based on stochastic distances, whereas the NL-SAR filter is based on the generalized likelihood ratio. Two measures were used for quality assessment: -index and -index. Over-segmentation was assessed by the -index, the ratio of the resulting number of segments to the number of connected components of the ground-truth classes. The accuracy of the best possible classification given on the segmentation result was assessed with ground truth information by maximizing the -index. A Monte Carlo experiment conducted on synthetic images shows that the quality measures significantly differ for the applied filters. Our results indicate that the use of an adaptive filter improves the performance of the segmentation. In particular, the combination of the mean-shift segmentation algorithm with the NL-SAR filter gives the best results and the resulting process is less sensitive to variations in the mean-shift operational parameters than when applying other filters or no filter. The results obtained may help improve the reliability of land-cover classification analyses based on an object-based approach on SAR data.","palabras_clave":"ACTIVE MICROWAVE|CLASSIFICATION|SEGMENTATION|SPECKLE FILTERING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":11700,"idioma_id":5,"titulo":"Trabajo doméstico no remunerado y uso del tiempo en la provincia de Santa Fe: una caracterización hacia 2013","resumen":"Con el advenimiento de la Modernidad dos dinámicas se entrelazaron para erigir a una específica noción de trabajo en un lugar hegemónico. La generalización de las relaciones de producción capitalistas y el proceso de escisión y especialización de los espacios en público\/laboral y privado\/doméstico entronizaron la noción de trabajo inscrita en la economía de mercado, a la vez que colocaron a las restantes formas de trabajo en un lugar subordinado. Sin embargo, el trabajo doméstico no remunerado ? en lo que se refiere a sus funciones de fondo ? sigue manteniendo una posición central en el proceso de reproducción social de la población en la medida que interacciona con el papel de los servicios públicos y la producción de bienes y servicios de mercados necesarios para la subsistencia de la población.  En este sentido, este trabajo presenta y analiza el tiempo dedicado por parte de la jefatura de hogar al trabajo doméstico no remunerado (que comprende los quehaceres domésticos, las actividades de cuidado de niños, enfermos o adultos mayores miembros del hogar y las actividades de apoyo escolar y\/o de aprendizaje a miembros del hogar) en la provincia de Santa Fe, a partir de los datos surgidos de la ?Encuesta sobre Trabajo No Remunerado y Uso del Tiempo?, implementada por primera vez en Argentina en el tercer trimestre de 2013, como módulo de la Encuesta Anual de Hogares Urbanos. Puesto que sin dudas, la estructura y las características socioeconómicas del hogar resultan un factor clave en el uso del tiempo de sus integrantes, para realizar el presente análisis se ha recurrido a construir tipologías de hogares en función de las siguientes variables: composición de la jefatura del hogar, existencia de miembros del hogar dependientes y en aquellos hogares con integrantes menores, número de componentes el hogar. En este sentido, el análisis se centra en el uso del tiempo de la jefatura del hogar de cada una de las tipologías construidas en función del ingreso per cápita familiar total.","palabras_clave":"Uso del Tiempo|Trabajo doméstico no remunerado|Provincia de Santa Fe|Tipología de hogares"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":12120,"idioma_id":5,"titulo":"La importancia de los ferrocarriles y las migraciones en las trayectorias territoriales de los pueblos del sur bonaerense. Estudio de caso: Hilario Ascasubi y Juan N. Fernandez entre 1880 y la actualidad","resumen":"La mayoría de las pequeñas localidades del sur bonaerense se originaron entre fines del siglo XIX y principios del siglo XX, vinculadas al modelo agroexportador argentino y a las necesidades de las potencias extra continentales, de organizar territorios extensos, funcionales a la economía mundial. Los ferrocarriles, el auge de la estructura agropecuaria y los movimientos migratorios marcaron la dinámica de este espacio. En el devenir histórico, y sobre todo en las últimas décadas de nuestro tiempo, con el impacto de la globalización, estos territorios se vieron sometidos a procesos de reestructuración espacial diferenciados. Cambios en la política económica, nuevas actividades y nuevos actores sociales produjeron un reordenamiento del territorio y una nueva dinámica de sus factores estructurantes.Para llevar a cabo la investigación se seleccionaron dos pueblos, Hilario Ascasubi y Juan N. Fernández. El objetivo del trabajo es comprender los factores que impulsaron el origen de los mismos y analizar, en perspectiva evolutiva y comparada, las características que fueron adquiriendo como consecuencia deprocesos de territorialización y desterritorialización a lo largo del tiempo.","palabras_clave":"Territorio|Reestructuración territorial|globalización|espacialidad"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":12237,"idioma_id":5,"titulo":"Personalización en aprendizaje colaborativo soportado por computadora mediante sistemas basados en agentes","resumen":"En los sistemas de Aprendizaje Colaborativo Soportado por Computadoras no alcanza con organizar a los estudiantes en grupos. El éxito en las experiencias de colaboración está condicionado (entre otros factores) por los roles que tanto estudiantes como profesores sean capaces de manifestar durante la dinámica de trabajo. En este artículo sepresentan dos sistemas basados en agentes especialmente diseñados. El primero está enfocado tanto a monitorear los roles de equipo desempeñados por los estudiantes en la dinámica de colaboración, como a intervenir de manera automática con acciones correctivas cuando esos roles no se muestran adecuadamente. El segundo sistema basado en agentes apunta tanto a la detección de conflictos grupales que requieran la intervención del profesor para resolverse, como a llevar a cabo el entrenamiento de esos profesores en la manifestación de los roles adecuados para resolver esos conflictos. Ambos sistemas están actualmente en desarrollo para su posterior validación experimental con estudiantes y docentes reales.","palabras_clave":"APRENDIZAJE COLABORATIVO SOPORTADO POR COMPUTADORA|ROLES DE EQUIPO|E-TUTORES|SISTEMA BASADO EN AGENTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":12398,"idioma_id":4,"titulo":"Maternal and neonatal epidemiological features in clinical subtypes of preterm birth","resumen":"OBJECTIVE:This study was designed to characterize and compare the maternal and newborn epidemiological characteristics through analysis of environmental factors, sociodemographic characteristics and clinical characteristics between the different clinical subtypes of preterm birth (PTB): Idiopathic (PTB-I), premature rupture of the membranes (PTB-PPROM) and medically indicated (PTB-M). The two subtypes PTB-I and PTB-PPROM grouped are called spontaneous preterm births (PTB-S).METHODS:A retrospective, observational study was conducted in 1.291 preterm nonmalformed singleton live-born children to nulliparous and multiparous mother´s in Tucumán-Argentina between 2005 and 2010. Over 50 maternal variables and 10 newborn variables were compared between the different clinical subtypes. The comparisons were done to identify heterogeneity between subtypes of preterm birth: (PTB-S) versus (PTB-M), and within spontaneous subtype: (PTB-I) versus (PTB-PPROM). In the same way, two conditional logistic multivariate regressions were used to compare the odds ratio (OR) between PTB-S and PTB-M, as well as PTB-I and PTB-PPROM. We matched for maternal age when comparing maternal variables and gestational age when comparing infant variables.RESULTS:The PTB-I subtype was characterized by younger mothers of lower socio-economic status, PTB-PPROM was characterized by environmental factors resulting from inflammatory processes, and PTB-M was characterized by increased maternal or fetal risk pregnancies.CONCLUSIONS:The main risk factor for PTB-I and PTB-M was having had a prior preterm delivery; however, previous spontaneous abortion was not a risk factor, suggesting a reproductive selection mechanism.KEYWORDS:Clinical subtypes; epidemiological features; pregnancy; preterm birth.","palabras_clave":"Clinical subtypes;| epidemiological features; |pregnancy; |preterm birth"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":12419,"idioma_id":5,"titulo":"Algoritmos de Búsqueda Dispersa aplicados a problemas de optimización discreta","resumen":"Algoritmos de Búsqueda Dispersa aplicados a problemas de optimización discreta","palabras_clave":"BUSQUEDA DISPERSA|PROBLEMAS DE OPTIMIZACION|METAHEURISTICAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":12574,"idioma_id":5,"titulo":"¿Puede el nuevo originalismo garantizar la inteligibilidad de la Constitución?","resumen":"[Artículo en revista indexada en Erih Plus, nivel I de la categorización de publicaciones periódicas de ciencias sociales y humanidades del CONICET]. El presente artículo se dirige a dos objetivos fundamentales. En primer lugar, se reconstruirán las directivas interpretativas y los presupuestos semánticos del «nuevo originalismo» u «originalismo del significado público y original». Esta teoría, en muy apretada síntesis, supone que el significado de las disposiciones constitucionales fue fijado según el uso lingüístico oficial de la época en que la Constitución fue adoptada y, además, que ese significado original es capaz de efectuar una contribución a la orientación y desarrollo de las prácticas constitucionales actuales. En segundo término, se examinarán las principales dificultades de una práctica interpretativa de tipo neo-originalista. Concretamente, se determinará la posibilidad de alcanzar o garantizar la objetividad de la interpretación constitucional a partir de los presupuestos semánticos sobre los que descansa el «nuevo originalismo».","palabras_clave":"Originalismo|Inteligibilidad|Constitución|Interpretación Constitucional"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":12682,"idioma_id":5,"titulo":"Agresividad y habilidades sociales. Un estudio preliminar con adolescentes de escuelas públicas","resumen":"La adolescencia ha sido&nbsp; un tema siempre presente en los estudios delas ciencias sociales. Pero en este siglo XXI ha adquirido un progresivoprotagonismo. Desde las políticas públicas en Latinoamérica se reconocen avancesen salud y educación, aunque persisten desafíos como la prevención de laviolencia y comportamientos vinculados a ésta, como la agresividad. Laagresividad y las habilidades sociales constituyeron el objeto de estudio deeste trabajo. Los objetivos fueron: a) Describir las habilidades sociales y elcomportamiento agresivo en adolescentes escolarizados de San Miguel de Tucumán(Argentina) de 12 a 17 años, residentes en zona urbana de nivel socio económicobajo. b) Comparar las habilidades sociales y el comportamiento agresivo segúnedad, sexo y tipo de familia.Método: se trata de una investigacióndescriptiva, de tipo no experimental, transversal, con adolescentes de escuelaspúblicas urbanas de San Miguel de Tucumán (Argentina). La muestra estuvoconformada por de 752 casos, seleccionada de manera no probabilística incidental.Los Instrumentos utilizados fueron: Batería de Socialización para adolescentes(BAS-3, Silva y Martorell), Cuestionario de Conducta Antisocial (CC-A,Adaptación Casullo) y una encuesta sociodemográficas. A partir de losresultados se argumenta que es esperable relacionar estilos de habilidadessociales y una de sus disfunciones, la agresividad, con variables contextualescomo sexo, edad y tipo de familia. Los resultados aportan datos paraencarar&nbsp; programas de intervención queprevengan comportamientos agresivos, valorando la capacidad para controlar losimpulsos y el respeto por las normas sociales. Ello asegurará modos de relacióninterpersonal saludables y faciliten la inclusión del adolescente en su grupode referencia.","palabras_clave":"AGRESIVIDAD|HABILIDADES SOCIALES|ADOLESCENTES|ESCUELA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":13156,"idioma_id":5,"titulo":"Los archivos paleoambientales en el Borde Oriental de la Puna y sus respuestas a los cambios naturales y antrópicos durante el Holoceno Noroeste argentino","resumen":"Se presentan resultados para el Holoceno de secuencias de acumulaciones de valles puneños en el Borde Oriental de la Puna jujeña. Los depósitos seleccionados (22º 06? S; 65º 28? N) cubren el lapso temporal 9000-2350 años cal. a. C. Se realizaron análisis palinológicos de minerales pesados y texturales, complementados con dataciones radiocarbónicas, análogos modernos para polen y proveniencia de minerales. Los datos actuales muestran grupos polínicos de estepas arbustivas puneñas, indicadores locales de humedad y disturbio antrópico: las clases texturales dominantes de materiales superficiales más friables corresponden a arenas finas y medias, con mayor porcentaje de hornblenda verde. Se discute el paleoambiente del Holoceno del valle con cauces fluviales someros vegetados, bajo clima regional árido-semiárido y estepa arbustiva puneña. Se destaca la abundancia de hornblenda verde, correlacionada a las zonas polínicas de pastizales y humedad local. Los sedimentos finos con clorita condicen con incrementos de indicadores de humedad local. Los cambios en la morfodinámica en el Holoceno medio y tardío, con reducción de la tasa de sedimentación, la tendencia sostenida al incremento del escurrimiento y las variaciones en los indicadores locales de humedad se produjeron por variaciones en el régimen de precipitación y\/o aumento de la actividad humana.","palabras_clave":"PALEOPALINOLOGIA|GEOARQUEOLOGÍA|POLEN|SEDIMENTOLOGÍA|BORDE ORIENTAL DE LA PUNA|HOLOCENO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":13268,"idioma_id":5,"titulo":"Las Reservas de Biosfera como instrumentos de gestión territorial:  la RB Yungas (Argentina)?,","resumen":"Las reservas de biosfera son áreas especiales declaradas por la unesco que deben combinar un triple objetivo de conservación de la naturaleza, desarrollo sostenible y apoyo logístico a la educación, la ciencia y la capacitación, en una perspectiva integrada. En 40 años, ellas se convirtieron en herramientascomplejas para la gestión y el ordenamiento territorial. La Reserva de Biosferade las Yungas (rbYungas), localizada en las provincias de Jujuy y Salta (Argentina), cubre una gran porción de selvas subtropicales de montaña yes un ecosistema de gran valor ambiental y social. Desde su creación, la Reserva pasó por diferentes etapas de implementación, y en 2010 concluyó el Plan Estratégico en una porción de su territorio (Jujuy). El objetivo de este trabajo es analizar el estado actual de planificación territorial en la rbYungasy su integración en el espacio regional. Para  ello, se concretó una revisión bibliográfica (científica y técnica) sobre el área de estudio y se analizaron documentos oficiales en torno al proceso de consolidación institucional de la rbYungas, los informes técnicos, su zonificación, el Plan Estratégico de la rbYungas-Sector Jujuy y los ordenamientos territoriales de bosques nativos provinciales correspondientes. Luego, se compararon los instrumentos cartográficos asociados y se discutieron la coherencia y la  integración de las orientaciones de la rbYungas con las políticas de gestión territorial. Con 13años de existencia, esta Reserva de Biosfera demostró avances en materia de planificación territorial y diálogo entre ambas provincias y actores involucrados. Sin embargo, quedan pendientes los desafíos de fortalecer la Reserva en todo su territorio y la necesidad de consolidar el papel de estemodelo en las políticas públicas puestas en marcha en el territorio.","palabras_clave":"integración |gestion territorial|reserva de biosfera|yungas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":13445,"idioma_id":5,"titulo":"Comentario a: ?Legalismo moral y tolerancia. Crónica de una muerte anunciada? de René González de la Vega","resumen":"En el presente número se recoge una discusión sobre ellugar que ocupa la tolerancia en el liberalismo. En coincidencia conesto, la teoría de John Rawls ha significado la posibilidad de conciliardiferentes ideas, bajo un esquema político justo y estable entrelos ciudadanos de una comunidad dividida por doctrinas religiosas,filosóficas o morales; la tolerancia será el mecanismo que contribuyaa enfrentar los conflictos que se susciten. Sin embargo, asumiendoque el pluralismo subsistirá, el concepto de tolerancia ha jugado unpapel central. Esta idea propone discutir René Gonzales de la Vega en?Legalismo moral y tolerancia. Crónica de una muerte anunciada?,del cual surge la preocupación de lo que significa la tolerancia para elciudadano, esto es, el costo que suele representarle.","palabras_clave":"Deontologismo|Ética de la virtud|Contextualismo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":14252,"idioma_id":4,"titulo":"Testing phosphate ions as corrosion inhibitors for construction steel in mortars","resumen":"The purpose of this investigation is to analyze the effectiveness of phosphates as inhibiting agents forsteel bars embedded in mortars. Three mix designs were selected for this study: mix A had no admixedchlorides and was used as reference; mix designs B and C were contaminated with 1% in weight ofchlorides\/weight of cement and mix C also incorporated 7% Na3PO4.12 H2O. After setting for 48 h, thesamples were cured for 7 days immersed in water. Three specimens of each group were then immersed inaerated saline solutions 0.5 mol L1 NaCl during 720 days. The corrosion potential(Ecorr), the polarizationresistance (Rp) and the electrochemical impedance spectra were recorded regularly. After 720 days ofimmersion one set of mortars was anodically polarized and another set cathodically polarized. After that,Raman spectra of corrosion products were registered. Additional specimens were used to evaluateporosity and chloride profiles. The presence of phosphate ions as inhibitors has no effect on Ecorr valuesand suggests mixed-type inhibition. Mix C remains passive until 180 days of exposure, withRt> 100 kVcm2. At longer times, Rt decreases in time but the inhibition percentage is always higherthan 95% when evaluated by impedance spectra. Using Rp, inhibition stays above 70%. Anodic andcathodic polarization curves, together with corrosion potential values, suggestthat phosphates behave asa mixed-type inhibitor.","palabras_clave":"Phosphate ions|Construction steel|Mortar|Corrosion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":14272,"idioma_id":4,"titulo":"'The cost of failing to prevent gas supply interruptions: A CGE assessment for Peru'","resumen":"Since 2000, there has been a noticeable progress in social and economic indicators of Peru. Even though the country risk has diminished dramatically, several threats remain. One of the key ones is the possibility of involuntary (transitory or permanent) interruptions of the natural gas pipeline transportation system. Given the significant endowments of natural gas reserves in Peru (Camisea gas field) and its relevance in the economy, shortages of natural gas due to pipelines failures can wreak havoc because it is important from the government revenue and it is a basic input for domestic manufacturing and household energy consumption.Earthquakes, unexpected social unrest or intentional actions could interrupt the service of some of the fundamental pipelines of the grid. One pipeline with three branches connects the upstream to the distribution centers. To take intoaccount the economy wide impact of the interruption of gas supply we built a CGE model considering modifications of relative prices, markets reactions and income effects.We simulate different scenarios considering the three most important branches of the Camisea pipeline. The results show that those shocks would represent an important decline of GDP in the short run when substitution is limited (about or 0.2% by day) and an abrupt reduction of welfare for households. The Estimated daily cost is in the range of 335 million of USD for the worst case scenario.","palabras_clave":"1"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":14340,"idioma_id":4,"titulo":"The composition of arbuscular mycorrhizal fungal communities in the roots of a ruderal forb is not related to the forest fragmentation process","resumen":"Land-use changes and forest fragmentation have strong impact on biodiversity. However, little is known about the influence of new landscape configurations on arbuscular mycorrhizal fungal (AMF) community composition. We used 454-pyrosequencing to assess AMF diversity in plant roots from a fragmented forest. We detected fifty-nine virtual taxa of AMF (VT; phylogenetically-defined OTUs)?including ten new VT?in the roots of Euphorbia acerensis. AMF communities were mainly composed of members of family Glomeraceae and were similar throughout the fragmented landscape, despite variation in forest fragment size (i.e. small, medium and large) and isolation (i.e. varying pairwise distances). AMF communities in forest fragments were phylogenetically clustered compared to the global, but not regional and local AMF taxon pools. This indicates that non-random community assembly processes possibly related to dispersal limitation at a large scale, rather than habitat filtering or biotic interactions, may be important in structuring the AMF communities. In this system, forest fragmentation did not appear to influence AMF community composition in the roots of the ruderal plant. Whether this is true for AMF communities in soil and the roots of other ecological groups of host plants or in other habitats deserves further study.","palabras_clave":"Arbuscular Mycorrhizal Fungi|ruderal plant|Global change|Land use|454-pyrosequencing|SSU"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":14474,"idioma_id":4,"titulo":"New remains and new insights on the Gondwanan meiolaniform turtle Chubutemys copelloi from the Lower Cretaceous of Patagonia, Argentina","resumen":"New cranial and postcranial remains of the Gondwanan meiolaniform turtle Chubutemys copelloi Gaffney, Rich, Vickers-Rich, Constantine, Vacca and Kool 2007 from the Lower Cretaceous Puesto La Paloma Member of the Cerro Barcino Formation (Chubut province, Patagonia, Argentina) are presented, described, and compared in this contribution. Carapace and plastral remains, pectoral and pelvic girdle, cervical and thoracic vertebrae, and the left maxilla and jugal are the new recovered elements from C. copelloi. These new remains were found in 2008 in Turtle Town locality, the same site where the holotype and referred specimens of C. copelloi had beenfound in 1997. The facies analysis of the sedimentary succession in Turtle Town and surrounding areas suggests a paleoenvironment constituted by a broad alluvial plain with influx of volcanic ash-falls, whose deposits were disturbed by pedogenesis or reworked by current flows that&nbsp; supplied water and sediment in ponded areas. The presence of a very thin shell, broad vertebrals (broader than pleurals), the presence of a shallow nuchal notch with the vertebral 1 almost reaching the anterior border of the carapace, the presence of costoperipheral fontanelles, and the presence of an ectepicondylar canal in the humerus, are the most notable features provided by the new remains. A cladistic analysis has been performed to test the phylogenetic position of C. copelloi. This phylogeny corroborates the basal position of C. copelloi among Meiolaniformes. The plausible phylogenetic relationships of the clade Meiolaniidae with other Gondwanan (e.g., Otwayemys cunicularius Gaffney, Kool, Brinkman, Rich, and Vickers-Rich 1998) or Laurasian Lower Cretaceous taxa (e.g., sinochelyids) are also discussed in this contribution. Taxa included in Meiolaniformes have been mainly found in Gondwana and as the most basal taxon was found in Patagonia, paleobiogeographic studies suggest this clade originated in South America. Due to the basal position of C. copelloi among Meiolaniformes the discovery of more and previouslyunknown remains of this species sheds light on the origin and early evolution of this curious clade.","palabras_clave":"MEIOLANIFORMES|CERRO BARCINO FORMATION|PALEOENVIRONMENT|GONDWANA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":14922,"idioma_id":4,"titulo":"Molar Mass Distributions in Homopolymer Blends from Multimodal Chromatograms obtained by SEC\/GPC with a Concentration Detector","resumen":"This article proposes data treatment for estimating the individual (and unimodal) molarmass distributions (MMDs) of each polymer component in a blend from multimodalconcentration chromatograms obtained by size exclusion chromatography (SEC\/GPC). TheDifferential Refractometer (DR) chromatograms are deconvoluted into linear combinationsof exponentially-modified Gaussian distributions. The deconvolutions are possible if theindividual peaks are not fully overlapped and if the mass fractions of the minor componentsare not too low. To help determine the number and approximate location of theindividual peaks, the second derivative of the chromatogram is employed. For blends ofchemically identical homopolymers, the deconvolution stage directly provides the massfractions of the individual peaks. For blends of two chemically different homopolymers,the chemical composition and detector responses of the individual components must bedetermined, for example with the help of dual detection (UV\/DR). The procedure wasvalidated with blends of a priori known components.","palabras_clave":"Size Exclusion Chromatography|Polymer Blends"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":15213,"idioma_id":4,"titulo":"Evidence of the production of 2n eggs in diploid plants of the  autopolyploid complex Turnera sidoides L. (Passifloraceae)","resumen":"Abstract Turnera sidoides is a complex of dystilous perennial rhizomatous herbs with five subspecies in which diploid (2n= 2x= 14) to octoploid (2n= 8x= 56) cytotypes were found.Previous studies have suggested an autopolyploid origin of the complex, and provided evidence for the production of 2n pollen in experimental conditions as well as in natural populations. However, only the production of 2n pollen has been demonstrated so far, while the production of 2n eggs on experimental crosses or in natural populations of T. sidoides remains unknown. In this paper we investigate the production of 2n eggs in diploid individuals to understand how they may have contributed to the origin and establishment of polyploids in diploid populations of T. sidoides. Our progeny test and flow cytometric analysis of seeds collected in natural populations of this species complex, show that the triploid embryos originated from 2n eggs, suggesting that 2n eggs can contribute to the origin of neopolyploids by sexual unilateral polyploidization as well as by sexual bilateral poliploidization. The occurrence of plants that continuously form many 2n eggs and pollen would play a key role in the establishment of neopolyploids in natural diploid populations.","palabras_clave":"Polyploidy|sexual polyploidization|2n eggs|Turnera sidoides"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":15308,"idioma_id":4,"titulo":"An Effective Power Quality Classifier Using Wavelet Transform and Support Vector Machines","resumen":"In this paper we propose a method based on a combination of binary classi&#64257;ers which are optimized for those special cases where the real signals contain a multitude of events within the analyzed temporal window. These type of events are known as complex events. The proposed Power Quality (PQ) classi&#64257;er is based on Wavelet Transforms (WT) and Support Vector Machines (SVM). The method uses a One vs. One multiclass SVM. We propose a novel method which is simple, easy to train, and can be implemented with low computational cost. The proposed algorithm consists of a set of simple binary SVM classi&#64257;ers. Each SVM node is trained separately allowing them to be parallelized. The training stage is performed using single events, however due to the structure of the SVM methodology selected, it allows the system to detect complex events. Tests and training were performed using real complex signals and the results show the proposed methodology to be highly ef&#64257;cient","palabras_clave":"Power Quality|Wavelet Transform"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":15334,"idioma_id":4,"titulo":"Evidence of the evolved nature of the B[e] star MWC 137","resumen":"The evolutionary phase of B[e] stars is difficult to establish due to the uncertainties in their fundamental parameters. For instance, possible classifications for the Galactic B[e] star MWC 137 include pre-main-sequence and post-main-sequence phases, with a large range in luminosity. Our goal is to clarify the evolutionary stage of this peculiar object, and to study the CO molecular component of its circumstellar medium. To this purpose, we modeled the CO molecular bands using high-resolution K-band spectra. We find that MWC 137 is surrounded by a detached cool (T = 1900 ± 100 K) and dense (N = (3 ± 1) x 10^21 cm-2) ring of CO gas orbiting the star with a rotational velocity, projected to the line of sight, of 84 ± 2 km s&#8722;1. We also find that the molecular gas is enriched in the isotope 13C, excluding the classification of the star as a Herbig Be. The observed isotopic abundance ratio (12C\/13C = 25 ± 2) derived from our modeling is compatible with a proto-planetary nebula, main-sequence, or supergiant evolutionary phase. However, based on some observable characteristics of MWC 137, we propose that the supergiant scenario seems to be the most plausible. Hence, we suggest that MWC 137 could be in an extremely short-lived phase, evolving from a B[e] supergiant to a blue supergiant with a bipolar ring nebula.","palabras_clave":"Emission line stars|Circumestellar matter|Early-type star|stars: emission-line|Be, stars: individual: MWC 137"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":15481,"idioma_id":4,"titulo":"Hypogonadotropic Hypogonadism in Infants with Congenital Hypopituitarism: A Challenge to Diagnose   at an Early Stage.","resumen":"Background: Combinedpituitary hormone deficiency (CPHD) has a variable spectrum of pituitary gland affectation. The postnatal gonadotrophic surge is a useful period for exploring the gonadotrophic axis in order to assess the presence of congenital hypogonadotrophic hypogonadism (CHH). Aim: to explore the hypothalamic-pituitary-gonadal axis function in the postnatal gonadotrophic surge to early diagnose CHH in newborns or infants with suspected CPHD. Subjects and Methods: Boys under 6 months (n=27) and girls under 24 months of age (n=19) with suspected hypopituitarism were included. Serum concentrations of LH, FSH, testosterone, inhibin-B, antimüllerian hormone (AMH) and oestradiol were measured and male external genitalia were characterised either normal or abnormal (micropenis, microorchidism and\/or cryptorchidism).Results: CPHD was confirmed in 36 out of 46 patients. Low LH and testosterone levels were found in 66% of the hypopituitary males, in significant association with the presence of abnormal external genitalia. This abnormality had a positive predictive value of having CHH of 93%. No significant association was observed between serum FSH, AMH and iInhibin-B and their external genitalia. Conclusions: In newborns or infantsboys with CPHD, LH and testosterone concentrations determined throughout the postnatal gonadotrophic surge together with a detailed evaluation of the external genital phenotype facilitates the diagnosis of CHH at an early stage.","palabras_clave":"Congenital hypogonadotropic hypogonadism|Gonadotropic surge|Inhibin B"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":15552,"idioma_id":5,"titulo":"El trabajo managerial. Las particularidades locales de un modelo hegemónico","resumen":"El artículo estudia el fenómeno del solapamiento salarial que se produce entre los cuadrosmedios de conducción y los obreros calificados a raíz del achicamiento de la brecha salarialentre ambos sectores, principalmente a causa del mayor peso que tomó el poder sindical y lanegociación colectiva del salario a partir de 2003. Este proceso permite entender la relaciónentre capital y trabajo en términos relacionales más que dicotómicos, en los que convergenprácticas de consenso y de resistencia entre las partes. El esquema de competencias regidopor el mérito individual (en detrimento de la acción colectiva) como mecanismo tomado por lossectores manageriales para regular las posiciones de los diferentes sectores dentro de laburocracia corporativa comienza a ser erosionado con la creación de nuevos sindicatos porparte de los mandos medios de conducción. La complejidad que tiene este sector que por unlado, actúa como agente del capital para con sus subordinados y por otro lado, no espropietario de los medios de producción aparece nuevamente a la hora de ver las diferentesmaneras con las que responde a este fenómeno: en forma individual u organizándosecolectivamente","palabras_clave":"TRABAJO MANAGERIAL|SOLAPAMIENTO SALARIAL|SINDICATOS|HEGEMONÍA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":15902,"idioma_id":5,"titulo":"Frente al límite del enfoque de derechos: la educación como política de prevención social del riesgo","resumen":"El artículo señala la confluencia entre los marcos conceptuales que organizaron las políticas educativas de las últimas décadas centradas en la noción de inclusión con aquellos destinados a los sectores más vulnerables de la población conocidos como políticas de gestión social del riesgo.  Se analizan las tendencias recientes de la educación argentina y su relación con  políticas públicas como la Asignación Universal por Hijo y políticas socio- educativas como Conectar Igualdad y Plan FINES. Se propone una hipótesis en torno a las dificultades de la escuela para alcanzar la inclusión en los aprendizajes, compatibilizando dos principios en apariencia contradictorios como son la inclusión y las competencias. Posteriormente, se abordan los conceptos de riesgo y prevención como organizadores de otras ?políticas sociales? orientadas a sectores vulnerables.  Finalmente se destaca que en las prácticas institucionales el enfoque inclusivo  no logró dar preeminencia a la construcción de los lazos sociales inherentes a la ciudadanía y que la lógica del enfoque de derechos se mantuvo en el plano de las competencias ligadas a la inserción ? jerárquica y diferencial- en el mercado laboral.","palabras_clave":"POLITICAS EDUCATIVAS|GESTION SOCIAL DEL RIESGO |INCLUSION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":15931,"idioma_id":4,"titulo":"Detection of thiourea from electrorefining baths using silver nanoparticles-based sensors","resumen":"A novel and easy-to-use colorimetric thiourea (TU) sensor based on immobilized polyvinylpyrrolidone-stabilized silver nanoparticles (PVP-AgNPs) is reported. The new sensor is aimed for its direct application in copper electrorefinery baths. Quantitative analysis was carried out by adding different thiourea amounts into a synthetic bath and monitoring the absorption changes of the surface plasmon resonance band (SPRB) by UV-Vis spectrophotometry. A linear correlation between the absorbance change and thiourea concentration was obtained, ranging from 0.125 mg\/L to 1 mg\/L. Our technique has the advantage of working in acidic and high ionic concentrated solutions as those used in electrorefinery baths. The influence of the nanoparticles synthesis conditions on the thiourea sensing was analyzed; particularly, the effect of using different silver concentrations and the same amount of borohydride ions as reducing agent ([Ag+]\/[BH4 -] ratios of 2:1, 8:1, 10:1 and 20:1 during the synthesis). The proposed system provides a simple, economical, easy-to-handle and rapid measurement tool for monitoring hydrometallurgical processes for optimizing the reconditioning of thiourea solutions, reducing its environmental impact.","palabras_clave":"SILVER NANOPARTICLES|THIOUREA|COPPER ELECTROREFINING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":15948,"idioma_id":4,"titulo":"Conodonts from the Cambrian-Ordovician boundary in the Cordillera Oriental, NWArgentina","resumen":"TheCambrian-Ordovician boundary in NW Argentina was originally proposed for thelower upper section of the Cardonal Formation in the Amarilla Creek, CajasRange, Cordillera Oriental of Jujuy, based on the first appearance of theconodont Cordylodus lindstromi. After the finding of the index fossil Iapetognathus,the intersystemic &nbsp;boundary in thisstratigraphic unit was recently verified. Through theupper 42 meters of the Cardonal Formation, which is 160 m in total thickness,conodonts of the Cordylodus lindstromi, Iapetognathus and Cordylodusangulatus zones were recovered. The lower upper section of the formationwhere is located the referred boundary consists of grey-greenish shalesinterbedded with calcareous sandstones that represent an upper off-shoreenvironment which deepens upwards. The associated species belong to the genera Acanthodus,Cordylodus, Eoconodontus, Furnishina, Iapetognathus,Orminskia,Phakelodus, Problematoconites, Proconodontus and Teridontus.Importantly, the index species Iapetognathus &nbsp;fluctivagus &nbsp;and &nbsp;I. jilinensis were documented for theregion in this study. The conodont species are mostly cosmopolitan, integratinga local fauna that is interpreted as representing the Transitional Faunal Realmof Mid-latitudes in the Cold Water Domain or to the lately defined SouthwesternGondwana Province from the Cold Domain in the Shallow-Sea Realm. The conodont &nbsp;elements exhibit a black color (CAI 5 = 300ºand 480º), with a significant alteration caused by a Jurassic-Cretaceousboundary hydrothermal influence.","palabras_clave":"Conodonts|Cambrian\/Ordovician|Biostratigraphy|NW Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":15970,"idioma_id":4,"titulo":"Effect of Daily Consumption of Lactobacillus reuteri CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects","resumen":"The effect of daily consumption of a yogurt containing Lactobacillus reuteri CRL 1098 on the lipidprofile of hypercholesterolemic subjects was evaluated by performing a prospective, randomized,double-blind, cross-over placebo controlled clinical study. Participants consumed daily a yogurtcontaining L. reuteri CRL 1098 or a placebo for four weeks, separated by a wash-out period. Totalcholesterol, triacylglycerol, high-density (HDL) and low-density (LDL) lipoprotein levels were assessedat the beginning and at the end of each period. We found a statistically significant reductionof total (&#8722;7.86 g\/dl) and LDL (&#8722;7.02 g\/dl) cholesterol in absolute changes (before-after) as well asa decreasing trend in the group receiving the yogurt containing L. reuteri with respect to the placebogroup, without detecting changes in HDL-cholesterol and triacylglycerol levels. Our resultssuggest that low amounts of yogurt (125 g\/day) and low doses of the CRL 1098 strain (106 CFU)are sufficient to reduce total and LDL-cholesterol levels in hypercholesterolemic subjects.","palabras_clave":"LACTOBACILLUS|HYPERCHOLESTEROLAEMIA|CHOLESTEROL REDUCTION|CARDIOVASCULAR DISEASE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":15982,"idioma_id":4,"titulo":"Bulky Monodentate Biphenyl Arsine Ligands: Synthesis and Evaluation of their Structure Effect in Palladium-Catalyzed Heck Reaction","resumen":"Biphenyl-based arsine ligands were prepared in two steps by Pd-catalyzed arsination and MW-assisted Suzuki-Miyaura coupling reaction, obtaining sterically demanded arsine ligands in overall isolated yields up to 82% as air-stable solids. Short reaction times were achieved by using the assistance of MW on the direct and simple described protocol for the synthesis of biarylarsine ligands. The activity of the biphenyl arsine ligands were explored in Pd-catalyzed Heck coupling reaction. As general trend, the ligands with blocked ortho-positions on the non-arsine containing ring of the biphenyl backbone were more efficient to performed the coupling reaction. This catalytic system allowed obtaining several interesting stilbenes in very good yields.","palabras_clave":"biaryls ligands | As ligands |microwave|palladium - Heck"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16060,"idioma_id":5,"titulo":"ODONTOLOGIA Y DISCAPACIDAD, MITOS PARA DERRIBAR","resumen":"&nbsp;Autor dela publicación ?ODONTOLOGIA Y DISCAPACIDAD, DERRIBANDO BARRERAS? publicado enla revista de la Catedra CLINICA DEL PACIENTE DISCAPACITADO, ?SONRISASESPECIALES? de la Facultadde odontología de la Universidad Nacional de Cuyo, Pags. 2 a 4, AÑO 5 Numero I&nbsp; ISSN 2314-1026. Diciembre 2015","palabras_clave":"ODONTOLOGIA|DISCAPACIDAD |SALUD|PREVENCION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16111,"idioma_id":5,"titulo":"Simbología no química utilizada por ingenieros civiles para los componentes del hormigón y sus transformaciones. Una propuesta de cambio a través del lenguaje químico.","resumen":"Parareferirse a la composición de los cementos, las transformaciones quesufren los materiales con los que se fabrica el cemento y losprocesos en los que el hormigón resulta atacado por diferentesagentes, los ingenieros civiles utilizan una simbología ?noquímica?. La misma no les facilita, entender las composiciones nilos procesos, sino todo lo contrario, y, lo que es más grave aún,no les permite una comunicación fluida con la literatura o conespecialistas. Además esta simbología es la que utilizan losingenieros civiles docentes en sus actividades frente a alumnos de locual resulta que los futuros ingenieros civiles tendrán lasdificultades ya apuntadas. En este trabajo se presentan, lasimbología ?no química? y la nomenclatura química que lainterpreta y que se emplea en los cursos básicos para ingenieríasno químicas. El trabajo es una propuesta de construcción designificados compartidos con los ingenieros civiles del ciclosuperior de la carrera, a cuenta de favorecer la comprensión de estatemática de alta complejidad y reducir los riesgos de una potencialincomunicación entre los dos momentos de la formación de ingenierosciviles.p { margin-bottom: 0cm; direction: ltr; color: rgb(0, 0, 0); text-align: justify; }p.western { font-family: 'Times New Roman', serif; font-size: 10pt; }p.cjk { font-family: 'Times New Roman', serif; font-size: 10pt; }p.ctl { font-family: 'Times New Roman', serif; font-size: 10pt; }a:link { color: rgb(0, 0, 255); }","palabras_clave":"QUÍMICA|INGENIERÍA CIVIL|SUSTANCIAS, MATERIALES,|VOCABULARIO,NOMENCLATURA."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16223,"idioma_id":4,"titulo":"Further comment to ??Reply to Comment on impact structures in Africa: A review (Short Note)?? by Reimold and Koeberl [J. Afr. Earth Sci. 100 (2014) 757?758]","resumen":"In a Comment on Reimold and Koeberl (2014a) to JAES, Acevedoet al. (2014) claimed an impact origin for Bajada del Diablo craterstrewnfield (BdD), a remote locality in Central Patagonia. Suchgenesis had been denied by Reimold and Koeberl (2014a), whorejected its relationship to any impact-cratering process since, intheir opinion, Acevedo et al. (2009, 2012, among other papers)had not found direct evidence of impact. Neither Professor WolfUwe Reimold nor Professor Christian Koeberl had visited the sitenor contacted us before about the nature of our investigations. Itwould have been nice to exchange information with theseresearchers, before they so strongly criticized our work, particularlywhen they have used, unnecessarily, quite offensive and bellicosewords, which we believe we do not truly deserve.Indeed, so far, meteorite fragments have not been found there yet,though in its place Fe?Ni- and lawrencite-bearing microsphereswere collected. Likewise, proof of shock metamorphism has not beenobserved, though some hints may have been unveiled. However, anew element of valid analyses for identification of possible astrobleme-strewn fields such as the case in question has been revealed:the fact that many similar, circular and problematic structures arediscovered over contiguous but different geological environments.In the countless discussions proposed up to now concerning definitiveevidence for impact origin of problematic structures it has neverbeen taken into account that a multiple collision of a fragmentedbody could affect different environments, thereby providing in itselfevidence for impact. That is what we think we have proven to havetaken place in Bajada del Diablo.In reply to our original Comment in JAES, Reimold and Koeberl(2014b) discarded for a second time the slightest possibility thatBdD might be an impacted area because, in a few words, the newinstance of impact identification does not appear within theirown scheme of impact evidence (French and Koeberl, 2010;Reimold and Koeberl, 2014a; Reimold et al., 2014), ignoring thatin the scientific world nobody should claim to be the unique ownerof the truth. Nevertheless, this is an interpretation which meritsbeing investigated, appealing to a presumption iuris tantum, inwhich incorrectness may be demonstrated only when enoughappropriate data are provided.Our research team that has studied this critical and remote localityhas been the only one working in situ; at the least, we think thatwe should be allowed the benefit of doubt. Our multidisciplinaryworking group has provided a clear, field based, geomorphologicalrecord hitherto unknown in other astrobleme-strewn fields inplaces where neither fragments of meteorites nor other elementswhich may unquestionably prove the existence of impacts havebeen found: that is, the presence of craters which formed simultaneouslyover two different geological substrata and regional landformssuch as basalt tablelands and piedmont gravels of clearlydifferent age.Arthur Conan Doyle used to say: ??When you have eliminatedthe impossible, whatever remains. . .must be the truth??. Duringour endless discussions, we have eliminated the impossible (e.g.volcanism, phreatomagmatism, ground subsidence, karst features,eolian deflation, biological origin, etc.). Thus, in scientific terms, itis reasonable to state that all bowl shaped depressions with raisedrims and stony ejecta blankets at Bajada del Diablo (with a total ofalmost 200), which equally affected volcanic and sedimentaryrocks are in fact impact craters. In other words, there is no neednow to discuss which has been the impactor, either a dismemberedasteroid or a comet, to recognize impact craters as such because noother known origin may be attributed to them. The fact that theyare affecting two geological environments and regional landformsof different age makes them the result of a unique event, which isnone other than an impact, unless Reimold and Koeberl have informationabout Bajada del Diablo that is unknown to us, which theseauthors are now reluctant to expose.Therefore, we suggest that basic geological aspects (whichshould not be ignored particularly if one has not done in situ observations)should never be left aside when geological dilemmas likethis need to be resolved. Likewise, we support that general anddetailed studies of regional geomorphological features should notbe overlooked in the study of astrobleme-strewn fields.Finally, the last paragraph of Reimold and Koeberl (2014b) haswrongly quoted one of our comments, namely that ??the absenceof evidence is not evidence of absence?? (Acevedo et al., 2014),not ??the absence of evidence is absence of evidence?? [sic] as theyhave paraphrased, which suggests an airily dismissive reading ofour paper.","palabras_clave":"no hay"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16248,"idioma_id":5,"titulo":"Políticas públicas, desarrollo y cooperativas agrarias","resumen":"El derrocamiento de Juan Domingo Perón en septiembre de 1955 abrió un nuevo escenario político, económico y social en la Argentina. La modernización  aparecía como premisa central en la sucesión de gobiernos dictatoriales y democráticos que condujeron el país hasta 1966. En este marco, las transformaciones en el agro se aceleraron. Para lograr este objetivo se pusieron en marcha programas gubernamentales de mecanización y tecnificación, que tuvieron considerable impacto en el sector rural. En esos programas era clara la influencia de las ideas desarrollistas de la Comisión Económica para América Latina (CEPAL), creada en 1948 y del argentino Raúl Prebisch.La progresiva liberación de los mercados, el fomento a la inversión extranjera, los beneficios fiscales a las empresas transnacionales y el ahorro interno, formaban parte del nuevo modelo económico. Las cooperativas agrarias no fueron ajenas a estas modificaciones macroeconómicas que se produjeron luego de 1955, cuando las políticas proteccionistas y de intervención estatal beneficiaban al sector. Este trabajo propone analizar el impacto de las políticas estatales ?de desarrollo? en las cooperativas rurales entre 1955 y 1966, profundizando en algunos aspectos de la región pampeana. Interesa reconocer el rol del Estado en la gestión de políticas públicas, cuando los intentos por estabilizar el sistema político caracterizaron al período mencionado. Para alcanzar los objetivos planteados, fueron utilizados programas agrarios oficiales, debates en los diarios de sesiones parlamentarias y diversas publicaciones periódicas de la época.","palabras_clave":"POLITICAS PUBLICAS|DESARROLLO|COOPERATIVAS AGROPECUARIAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16470,"idioma_id":4,"titulo":"MORPHOLOGICAL AND FUNCTIONAL VARIABILITY ON THE ENDSCRAPERS IN CUEVA MARIPE SITE (SANTA CRUZ PROVINCE, ARGENTINA)","resumen":"The aim of this paper is to study the end-scrapers recovered from Cueva Maripe site (Santa Cruz Province, Argentina).These artifacts have been repeatedly recorded along the entire sequence of the site occupations; therefore, the following work is focused on the morphological and functional variability of these instruments, to discuss some expectations regarding the permanence of certain kinds of design over time. The results allowed identifying different activities developed with these tools along the Cueva Maripe occupations, as the work on bone, wood, and hide.However, the morphological variability identified was mainly related to different kinds of flakes or blades selection and on the particular features of the edges which would indicate some versatility in design and little functional specialization. These features would account for the permanence of these instruments in the site from the early Holocene, as well as at a regional level in the central plateau of Santa Cruz.Este trabajo tiene por objetivo el estudio de los raspadores recuperados del sitio arqueológico Cueva Maripe (Prov.De Santa Cruz, Argentina), dado que se registran recurrentemente a lo largo de toda la secuencia de ocupación del sitio. Por lo tanto, el siguiente trabajo se encuentra focalizado en la variabilidad morfológica de estos conjuntos y surelación con la variabilidad funcional, a fin de discutir expectativas en cuanto al porqué de la permanencia de determinadas formas de diseño a través del tiempo. Los resultados alcanzados permitieron identificar el desarrollo de diferentes tareas a partir de estos instrumentos en las distintas ocupaciones de Cueva Maripe, desde el trabajo sobre hueso y madera hasta el tratamiento de pieles o cueros. Sin embargo, las Diferencias morfológicas identificadas, principalmente en la selección de formas bases, como en las características articulares de los filos utilizados, permitirían plantear cierta versatilidad en el diseño y poca especialización funcional, lo que habría llevado a la permanencia de estos instrumentos en el sitio desde el Holoceno emprano, como así también a nivel regional en distintos sectores de la meseta central de Santa Cruz.","palabras_clave":"RASPADORES|ANALISIS FUNCIONAL|CAZADORES-RECOLECTORES|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16492,"idioma_id":4,"titulo":"RECONSTRUCTION AND PHYLOGENETIC SIGNIFICANCE OF A NEW EQUISETUM LINNAEUS SPECIES FROM THE LOWER JURASSIC OF CERRO BAYO (CHUBUT PROVINCE, ARGENTINA)","resumen":"We describe Equisetum dimorphum sp. nov. from the Lower Jurassic of Chubut Province, Patagonia, Argentina. This new species is based on fertile and vegetative remains preserved as impressions of stems, leaves, strobili, transversal sections of the stems showing their anatomy, and terminal pagoda-like structures. The fine-grained sedimentary matrix also preserved detailed impressions of epidermal fea- tures. The morphological characters allow a whole-plant reconstruction and assignment to Equisetum. Equisetum dimorphum sp. nov. shows a mosaic of morphological characters that are commonly present in other Mesozoic forms and representatives of the two extant Equisetum sub- genera, e.g., sunken stomata and a blunt strobilus apex. Compared to other well-known Mesozoic equisetalean taxa, Equisetum dimorphum sp. nov. appears to be most closely related to a group of Jurassic Equisetum-like plants including Equisetum laterale Phillips and Equisetites ferga- nensis Seward. Additional evidence for the morphological stasis of the fertile and vegetative organs of extant horsetails is supplied with this new material, adding further support to the hypothesis that the extant horsetails are a successful group that has undergone only little mor- phological changeover time and that has been present, nearly worldwide, since Jurassic times.","palabras_clave":"EQUISETALES|JURÁSICO|CHUBUT|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16760,"idioma_id":4,"titulo":"Beneficial Effects of Fermented Sugarcane Residue with Goat Probiotic On Gut Health","resumen":"Abstract ? Sugarcane is rich in dietary fibers that have beneficial properties in gastrointestinal tract. In addition the sugarcane is well known for its protective role in mammalian health. However, the sugarcane industry produces vast quantities of residues. Sugarcane blunting (waste produced by the sugarcane industry) was fermented under different conditions: using native microbiota (control), using specific goat probiotics, including Lactobacillus reuteri DDL19  (Treatment Nº1), Lactobacillus alimentarius DDL 48 (Treatment Nº2), Enterococcus faecium DDE 39 (Treatment Nº3), Bifidobacterium bifidum DDBA (Treatment Nº4) and a probiotic mixture containing equal amounts of the four probiotics (Treatment N°5). The fermented sugarcane is a synbiotic supplement for goats because it contains goat probiotic as well as dietary fibers considered as prebiotic.  Firstly, the ensilages were microbiologically examined and then administered simultaneously to different batches of six goats each immediately after weaning. We evaluated the five different treatments during three consecutive periods of  seven days each (ingest-repose), starting immediately after weaning. The best results were obtained with the probiotic mixtures of strains belonging to different genera and species. The ingestion of the Treatment 5 was able to diminish coliforms and enhance the beneficial Bifidobacterium and lactic acid bacteria by at least one logarithmic unit with respect to the control. Furthermore, the incidence of diarrhea in this experimental group was lower than the control group. The intestinal flora was improved in all cases in which sugar  cane fermented with the probiotic strains was consumed. The residue is a good vehicle for probiotic strains, providing sugars and dietary fibers in a period of drought and in geographical areas of poor pastures. In this work, we use an  industrial solid waste (highly polluting) as synbiotic supplement food for goats.","palabras_clave":"GOATS|PROBIOTIC|SILAGE|SUGARCANE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16805,"idioma_id":4,"titulo":"COUPLING SCALES FOR MODELLING HEAVY METAL VAPORIZATION FROM MUNICIPAL SOLID WASTE INCINERATION IN A FLUID BED BY CFD","resumen":"Municipal Solid Waste Incineration (MSWI) in Fluidized bed is a very interesting technology mainly due to high combustion efficiency, great flexibility for treating several types of waste fuels and reduction in pollutants emitted with the flue gas. However, there is a great concern with respect to the fate of heavy metals (HM) contained in MSW and their environmental impact. In this study, a coupled two-scale CFD model was developed for MSWI in a bubbling fluidized bed. It presents an original scheme that combines a single particle model and a global fluidized bed model in order to represent the HM vaporization during MSW combustion. Two of the most representative HM (Cd and Pb) with bed temperatures ranging between 923 and 1073 K have been considered. This new approach uses ANSYS FLUENT 14.0 as the modelling platform for the simulations along with a complete set of self-developed user-defined functions (UDFs). The simulation results are compared to the experimental data obtained previously by the research group in a lab-scale fluid bed incinerator. The comparison indicates that the proposed CFD model predicts well the evolution of the HM release for the bed temperatures analyzed. It shows that both bed temperature and bed dynamics have influence on the HM vaporization rate. It can be concluded that CFD is a rigorous tool that provides valuable information about HM vaporization and that the original two-scale simulation scheme adopted allows to better represent the actual particle behaviour in a fluid bed incinerator.","palabras_clave":"FLUIDIZED BED|WASTE INCINERATION|HEAVY METAL VAPORIZATION|COMPUTATIONAL FLUID DYNAMIC|TWO-SCALE MODELING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16929,"idioma_id":4,"titulo":"Comparative study of mitotic chromosomes in  two blowflies, Lucilia sericata and L. cluvia (Diptera,  Calliphoridae), by C- and G-like banding patterns and  rRNA loci, and implications for karyotype evolution","resumen":"The karyotypes of Lucilia cluvia (Walker, 1849) and L. sericata (Meigen, 1826) from Argentina were characterized using conventional staining and the C- and G-like banding techniques. Besides, nucleolus organizer regions (NORs) were detected by fluorescent in situ hybridization (FISH) and silver staining technique. The chromosome complement of these species comprises five pairs of autosomes and a pair of sex chromosomes (XX\/XY, female\/male). The autosomes of both species have the same size and morphology, as well as C- and G-like banding patterns. The X and Y chromosomes of L. cluvia are subtelocentric and easily identified due to their very small size. In L. sericata, the X chromosome is metacentric and the largest of the complement, showing a secondary constriction in its short arm, whereas the Y is submetacentric and smaller than the X. The C-banding patterns reflect differences in chromatin structure and composition between the subtelocentric X and Y chromosomes of L. cluvia and the biarmed sex chromosomes of L. sericata. These differences in the sex chromosomes may be due to distinct amounts of constitutive heterochromatin. In L. cluvia, the NORs are placed at one end of the long-X and of the long-Y chromosome arms, whereas one of the NORs is disposed in the secondary constriction of the short-X chromosome arm and the other on the long-Y chromosome arm in L. sericata. Although the G-like banding technique does not yield G-bands like those in mammalian chromosomes, it shows a high degree chromosomal homology in both species because each pair of autosomes was correctly paired. This chromosome similarity suggests the absence of autosomal rearrangements during karyotype evolution in the two species studied.","palabras_clave":"BLOWFLIES|KARYOTYPE EVOLUTION|SEX CHROMOSOMES|HETEROCHROMATIN|G-LIKE BANDING PATTERN|rDNA-FISH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16930,"idioma_id":4,"titulo":"Lipid-free Antigen B Subunits from Echinococcus granulosus: Oligomerization, ligand binding, and membrane interaction properties","resumen":"Echinococcus granulosus is the causative agent of hydatidosis, a highly pathogenic infection that affects humans and livestock with significant economic and public health impact worldwide. Antigen B (EgAgB), an abundant product of this larva, is a lipoprotein that carries a wide variety of lipids, including fatty acids and cholesterol. As Echinococcus is unable to synthesize these lipids, it is thought that EgAgB could play an important role in parasite metabolism, participating in both the acquisition of lipids form the host and their distribution between the tissues of the parasite. The protein component of EgAgB consists of five different variants or isoforms of 8-kDa in mass, called EgAgB8\/1 to EgAgB8\/5. It is still unknown how EgAgB protein and lipid moieties are assembled into the native particle, and whether EgAgB isoforms bind and transfer different lipid classes. Herein we analysed the biochemical properties of lipid-free EgAgB8\/2 and EgAgB8\/3. Both isoforms were able to oligomerize even in the absence of lipids, and were capable of binding and transferring fatty acids, but not cholesterol, to phospholipid membranes. Taken together our results support the hypothesis that EgAgB is involved in the acquisition of host fatty acids and their distribution within the parasites.","palabras_clave":"lipid binding proteins|Antigen B|hydatid disease|E. granulosus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16931,"idioma_id":4,"titulo":"Removal of heavy metals from wastewater using magnetic nanocomposites: Analysis of the experimental conditions","resumen":"This contribution provides insight on the elimination of heavy metals from water resources using magnetic separation. Nanocomposites based on magnetite and chitosan were prepared. An exhaustive characterization of the magnetic adsorbents was developed. Adsorption assays were performed in batch using Cu, Zn, Cd and Cr as model heavy metals. The efficiency of magnetic adsorbents followed the order: Cu &#61502; Cd &#61502; Zn &#61502; Cr, with maximum values of 188, 159, 72 and 46 mg of Me\/g of nanocomposite, respectively. Kinetics and mechanistic issues were studied. The magnetic materials were efficient for five to eight cycles using Cu(II),Cd(II) and Cr(VI) .","palabras_clave":"MAGNETIC SEPARATION |NANOADSORBENTS |CHITOSAN|HEAVY METALS|IRON OXIDES|NANOCOMPOSITES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16932,"idioma_id":4,"titulo":"Epithelial cancer biomarker EpCAM determination in peripheral blood samples using a microfluidic immunosensor based in silver nanoparticles as platform","resumen":"In the present work, we report a microfluidic immunosensor for epithelial cancer biomarkerepithelial cell adhesion molecule (EpCAM) determination. It is based on the useof synthetized silvernanoparticles (AgNPs) covered by chitosan (Cts). AgNPs-Cts were covalently attached to the central channel (CC) of themicrofluidic immunosensor. These nanoparticles were employed as platform for anti-EpCAM monoclonalantibodies immobilization for specifically recognize and capture EpCAM in peripheral blood samples. Afterwards, the amount ofthis trapped epithelial cancer biomarker was quantified by HRP-conjugatedanti-EpCAM-antibody. HRP reacted with its enzymatic substrate in a redox process whichresulted in the appearance of a current whose magnitude was directly proportionalto the level of EpCAM in the peripheral blood sample. Thestructure and morphology of synthetized AgNPs-Cts were characterized by UV-visiblespectroscopy, scanning electron microscopy (SEM), energy dispersivespectrometer (EDS) and X-ray diffraction (XRD). The calculated detection limits for microfluidic immunosensor and thecommercial ELISA were 2.7 and 13.9 pg mL-1, respectively and thewithin- and between-assay coefficients of variation were below 6.37% for theproposed method. The microfluidicimmunosensor is simple, sensitive, specific and reproducible. It has thepotential for reliable point-of-care clinical diagnosis and prognosis of epithelial origin tumors inbiological samples.","palabras_clave":"EpCAM|epithelial cancer|circulating tumour cells|microfluidic immunosensor"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":16933,"idioma_id":4,"titulo":"Liver fluke (Fasciola hepatica) naturally infecting introduced European Brown hare (Lepus europaeus) in northern Patagonia: phenotype, prevalence and potential risk","resumen":"Fascioliasis has recently been included in the WHO list of Neglected Zoonotic Diseases. Besides being a major veterinary health problem, fascioliasis has large underdeveloping effects on the human communities affected. Though scarcely considered in fascioliasis epidemiology, it is well recognized that both native and introduced wildlife species may play a significant role as reservoirs of the disease. The objectives are to study the morphological characteristics of Fasciola hepatica adults and eggs in a population of Lepus europaeus, to assess liver fluke prevalence, and to analyze the potential reservoir role of the European brown hare in northern Patagonia, Argentina, where fascioliasis is endemic. Measures of F. hepatica found in L. europaeus from northern Patagonia demonstrate that the liver fluke is able to fully develop in wild hares and to shed normal eggs through their faeces. Egg shedding to the environment is close to the lower limit obtained for pigs, a domestic animal whose epidemiologicalimportance in endemic areas has already been highlighted. The former, combined with the high prevalence found (14.28%),suggest an even more important role in the transmission cycle than previously considered. The results obtained do not only remark the extraordinary plasticity and adaptability of this trematode species to different host species, but also highlight the role of the European brown hare, and other NIS, as reservoirs capable for parasite spillback to domestic and native cycle, representing a potentially important, but hitherto neglected, cause of disease emergence.","palabras_clave":"Fasciola hepatica|Lepus europaeus|introduced species|reservoir"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17011,"idioma_id":5,"titulo":"La valorización del patrimonio arqueológico y la construcción del pasado en la ciudad de Rosario: socialización desde los proyectos de voluntariado universitario","resumen":"En este trabajo se da a conocer la experiencia sobre la valorización del patrimonio arqueológico y la construcción del pasado en la ciudad de Rosario a partir de las actividades desarrolladas en el marco del Proyecto de Voluntariado Universitario Estudiantil titulado ?Socialización del pasado arqueológico para la construcción de una sociedad inclusiva?. El objetivo central se relacionó con la puesta en valor del patrimonio arqueológico así como con la socialización del conocimiento sobre el pasado regional. El proyecto fue concretado mediante el desarrollo del vínculo escuela-universidad.","palabras_clave":"PROYECTO DE VOLUNTARIADO UNIVERSITARIO|PATRIMONIO ARQUEOLÓGICO|SOCIALIZACIÓN |PASADO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17031,"idioma_id":4,"titulo":"Self-organized drug-interpolyelectrolyte nanocomplexes loaded with anionic drugs. Characterization and in vitro release evaluation","resumen":"The current study is focused on physicochemical characterization and in vitro drug delivery evaluation of self-organized nanoparticles based on drug-interpolyelectrolyte complexes (DIPEC). The interaction between two oppositely charged polymethacrylates, Eudragit® EPO and L100, and four non-steroidalanti-in&#64258;ammatory drugs, Salicylic Acid, Benzoic Acid, Ketoprofen and Naproxen was studied. DIPEC nanoparticles produce translucent and stable aqueous  dispersions where a remarkably high proportion of drug (between 57 and 95%) is condensed with polyelectrolyte (PE) under the form of ionic pairs. They exhibited particle size in the range of 120e198 nm and high positive zeta potential, contributing to physical stability. The sign of zeta potential shifted from positive to negative by changes in composition of DIPEC. Thermal analysis and X-ray diffraction patterns of freeze dried DIPEC showed the amorphous state of products and the complete interaction of PE and drug. Solid complexes were easily redispersed in water yielding nearly the same parameters of fresh dispersions. In vitro release experiments showed that DIPEC nanodispersions behave as drug reservoirs, exhibiting a slow drug release rate in water, which signi&#64257;cantly increased in simulating physiological &#64258;uids, promoted by ionic exchange. They also exhibited a remarkable robustness towards simulated physiological media of different pH.","palabras_clave":"DRUG-INTERPOLYELECTROLYTE COMPLEXES|EUDRAGIT® L100 y EPO|SELF-ORGANIZED NANOCOMPLEXES|DRUG DELIVERY SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17135,"idioma_id":5,"titulo":"Posiciones docentes del profesorado para la enseñanza secundaria en la      Argentina: una mirada histórica para pensar el presente","resumen":"Mucho se discute hoy acerca de la escuela media. En el centro de esos debates está la tarea de los profesores y su formación. ¿Quiénes eligen formarse y trabajar como profesores de escuela secundaria? ¿Qué traen de nuevo? ¿Qué pasó con el prestigio y la autoridad que supuestamente los rodeaba anteriormente? ¿Qué relación tienen esos cambios con la masificación de la escuela media? ¿Y con las transformaciones socioculturales contemporáneas? Para comprender estas problemáticas actuales, en este escrito buscamos indagar la construcción histórica de la formación de profesores colocando en el centro tanto la tarea como las cuestiones de autorización cultural y las condiciones concretas en las que se desarrolla la tarea. ¿Cuáles son las voces autorizadas para la posición de profesor? ¿Cuáles son desplazadas? ¿Cómo cambian en el tiempo esas posiciones públicas? ¿Qué tradiciones y disputas se hibridizan en esa construcción? Se busca dar cuenta de los cambios que atravesó la tarea y el reconocimiento público de los profesores identificando cuatro posiciones docentes en la historia de la escuela secundaria argentina. Especialmente, se utilizan marcas que la experiencia del trabajo docente ha dejado en la literatura, ya sea en forma de memorias o de relatos de ficción, para dar cuenta de las formas más subjetivas que tomaron las posiciones docentes identificadas.","palabras_clave":"FORMACIÓN DE PROFESORES |POSICIÓN DOCENTE|ARGENTINA|ESCUELA SECUNDARIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17162,"idioma_id":4,"titulo":"Lagrange approximation in Banach spaces","resumen":"Starting from Lagrange interpolation of the exponential function $e^z$ in the complex plane, and using an integral representation formula for holomorphic functions on Banach spaces, we obtain Lagrange interpolating polynomials for representable functions defined on a Banach space $E$. Given such a representable entire funtion $f: E \\to \\mathbb C,$ in order to study the approximation problem and the uniform convergence of these polynomials to $f$ on bounded sets of $E$, we present a sufficient growth condition on the interpolating sequence.","palabras_clave":"Lagrange|Approximation|Banach"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17163,"idioma_id":4,"titulo":"The hamster cheek pouch model for field cancerization studies","resumen":"The hamster cheek pouch model for field cancerization studies","palabras_clave":"hamster cheek pouch model |field cancerization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17164,"idioma_id":4,"titulo":"Use of silencing reporter and agroinfiltration transient assays to evaluate the potential of hpRNA construct to induce multiple tospovirus resistance","resumen":"Tospoviruses are devastating plant viruses causing severe economic losses in a diverse range of crops worldwide. Here, we describe the development and evaluation of an RNA interference (RNAi) broad-spectrum virus resistance strategy based on a unique and short hairpin-RNA-generating construct (pNhpRNA). This construct was designed from a region of the nucleocapsid gene (N) of Tomato spotted wilt virus (TSWV) that showed a high sequence identity to the corresponding region in the related species Groundnut ringspot virus (GRSV) and Tomato chlorotic spot virus (TCSV). To test the effectiveness of the pNhpRNA construct, we developed a silencing reporter assay based on three fusion proteins in which the complete viral N gene sequence from each of the three tospoviruses was fused in frame to the green fluorescent protein (GFP) sequence. Co-agroinoculation of these constructs with pNhpRNA into leaves of Nicotiana benthamiana resulted in a strong silencing phenotype determined by GFP decay and suppression of the three N genes at the RNA and protein levels. To test the potential of the pNhpRNA construct to generate virus-resistant plants, we infiltrated the whole shoots of N. benthamiana with pNhpRNA. When these infiltrated plants were mechanically inoculated with the mentioned viruses 100, 70, and 60 % resistance phenotypes to TSWV, GRSV, and TCSV, respectively, were observed. The induction of a broad tospovirus resistance with a simple construct and a minimized off-target effect are the main contributions of pNhpRNA.","palabras_clave":"broad-spectrum resistance|Nicotiana benthamiana|tobacco|transgene evaluation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17165,"idioma_id":4,"titulo":"Wear resistance of Fe-based nanostructured hardfacing","resumen":"The purpose of this work was to study the microstructural evolution and wear resistance of a nanostructured iron-based alloy deposited by FCAW process. Two samples with one and two layers were welded under Ar-20CO2 shielding and heat input of 3.5 kJ\/mm. Chemical composition was determined and microstructure was studied using both optical and electronic microscopy and X ray diffraction. Microhardness, cristallite size, percentage of dilution and abrasive wear resistance were measured. The microhardness of the deposit was found between 800 and 920 HV2, depending on the number of layers as well as the chemical composition of the samples. The wear test results were discussed in relation to chemical composition, microstructure and microhardness.","palabras_clave":"wear|nanostructured|hardfacing|FCAW"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17166,"idioma_id":4,"titulo":"Characterization of AA6061 alloy oxides obtained in high purity water and in diluted NaCl solution","resumen":"Spent aluminum-clad fuel elements from Argentine experimental nuclear reactors, manufactured with AA6061 aluminum alloy, are submitted to interim storage in demineralized water basins. In order to characterize the oxides grown during the storage, immersion tests of AA6061 samples were performed for periods from 3 days to 4 months at open circuit potential (OCP) and at room temperature in high purity water and in diluted NaCl solution. Electrochemical Impedance Spectroscopy (EIS) measurements were then performed on the oxide samples. The film thicknesses of oxides grown in high purity water, measured by eddy-currents technique, can be fitted to a sigmoidal curve reaching a limit value of ~11µm after 60 days of immersion, while the oxides obtained in diluted NaCl solution grow according to a linear law and reach a thickness of ~26µm after 120 days. From data obtained of fitting the EIS spectra with equivalent circuits, the thicknesses of the barrier layer present in the oxide were estimated for samples obtained in both media.","palabras_clave":"ALUMINUM|AA6061|OXIDE|EIS|CORROSION|CHLORIDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17167,"idioma_id":4,"titulo":"Phylogenetics based on partial ORF2 of Triatoma Virus in Triatomines Collected Over a Decade from Domiciliary Habitats","resumen":"The only virus sequenced and studied in triatomines is the Triatoma virus, from the Dicistroviridae family, which causes delayed development, reduced oviposition, and premature death of infected insects. With the goal of expanding the sequences already obtained in previous years and verifying if any changes occurred in their genomic sequences, 68 samples of triatomines from several provinces of Argentina were analyzed. Sixteen positive samples were obtained by Reverse Transcription (RT)-polymerase chain reaction using the VP3-VP1 subregion of open reading frame-2 as a diagnostic method; after sequencing, 11 samples were obtained from Triatoma infestans. These new sequences showed no significant differences in the analyzed regions, which were not grouped by species or habitat or geographical distribution. There were no differences when compared with the sequences found during 2002-2012, all obtained from the wild. We conclude that despite being an RNA virus, the different sequences show high homology.","palabras_clave":"Triatoma infestans|domiciliary habitat|Triatoma virus|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17168,"idioma_id":4,"titulo":"Morphological study of the prostate gland in viscacha (Lagostomus Maximus Maximus) during periods of maximal and minnimal reproductive activity.","resumen":"The aim of the present work was to study the morphological variations of the prostate in viscacha (Lagostomus maximus maximus) during periods of maximal and  minimal reproductive activity. This wild rodent exhibits an annual reproductive cycle. The prostate presents two different regions: peripheral and central. The peripheral zone has few folds containing large adenomeres covered by a pseudostratified epithelium with basal and principal cells. Principal cells show variations in their shape, size and ultrastructural characteristics during the period of minimal reproductive activity as compared to the active period. These results suggest that principal cells exhibit a reduced synthesis and release of secretory material during the period of less reproductive activity. The expression of the androgen receptor in the epithelium and in the fibromuscular stroma is significantly higher during the reproductive period as compared to the gonadal regression period. The central zone has small adenomeres with pseudostratified epithelium exhibiting principal and basal cells. The mucosa presents numerous folds during the reproductive activity. The glandular epithelium shows a low secretory activity during period of minimal reproductive activity. The immunohistochemical expression of androgen receptor is intense in the epithelial cells and weak in stromal cells during the reproductive period. These results may indicate that adult male viscacha prostate presents morphological changes during the reproductive cycle related to the variations previously reported in gonads of this rodent. Furthermore, the variations observed in the androgen receptors suggest a direct effect of circulating testosterone on the gland.","palabras_clave":"Prostate gland|Histology|Morphometric parameters|Reproductive activity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17169,"idioma_id":4,"titulo":"Polyethyleneimine coating of magnetic particles increased the stability of an immobilized diglycosidase","resumen":"The diglycosidase, &#945;-rhamnosyl-&#946;-glucosidase, from Acremonium sp. DSM24697 was immobilized by adsorption and cross-linking onto aniline-iron particles (PI). The immobilization yield was 31.2% with 8.9% immobilization efficiency, but the preparation loss stability in comparison with the soluble form of the enzyme in operational conditions at 60 °C. One parameter involved in the reduced stability of the heterogeneous preparation was the protein metal catalyzed oxidation achieved by iron traces supplied from the support. To overcome the harmful effect, iron particles were coated with polyethyleneimine (0.84 mg\/g) previous to the immobilization of the catalyst. The increased stability of the catalyst was correlated with the amount of iron released from the support. In operational conditions, the uncoated particles lost between 76&#9472;52% activity after 2 cycles of reuse, while PEI-coated preparation reduced 45&#9472;28% activity after 5 cycles of reuses in the range of pH 5.0 to 10 respectively. Hence, polymer coating of magnetic materials used as enzymes supports might be an interesting approach to improve the performance of biotransformation processes.","palabras_clave":"DIGLYCOSIDASE|ACREMONIUM|METAL-CATALYZED OXIDATION|ALPHA-RHAMNOSYL-BETA-GLUCOSIDASE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17170,"idioma_id":5,"titulo":"Contribución al conocimiento de la herpetofauna de Bahía Negra y sus alrededores, departamento Alto Paraguay, Paraguay","resumen":"Se dan a conocer nuevos registros de anfibios y reptiles&nbsp; del Distrito de Bahía Negra, Departamento Alto Paraguay, con la finalidad de contribuir al conocimiento de la herpetofauna del Paraguay.","palabras_clave":"ANFIBIOS|REPTILES|CHACO|PANTANAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17171,"idioma_id":4,"titulo":"pH-responsive hydrogels to protect IgY from gastric conditions: In vitro evaluation","resumen":"Oral administration of specific egg yolk immunoglobulin (IgY) is  effective against a number of gastrointestinal pathogens. However, the activity  of orally administered IgY is reduced rapidly, since IgY is sensitive to pepsin  and low pH. In this study, hydrogels containing acrylamide and acrylic acid  were synthesized and used to encapsulate IgY. The capacity of these structures  to load, protect and release IgY and the interaction between IgY and hydrogels  by FTIR spectroscopy were studied. The particle size and swelling percentage of  hydrogels were highly dependent on the pH of the buffer solution. As expected,  pH-sensitive hydrogels had a high IgY loading percentage (99.2±12.9mg IgY\/mg  hydrogel) at pH 7.4. It means that each gel piece incorporated approximately 8.4±1.1  mg IgY. The results showed that the hydrogels could efficiently incorporate IgY  and retain it inside the polymer network at pH &lt;2.2. However, IgY was slowly  released at basic pH and a high percentage remained inside. The IR spectra show  that IgY interacts with the hydrogel in its network with extended hydrogen  bonds. The present study demonstrates that hydrogels particles can efficiently  incorporate the IgY but cannot show a controlled and sustained release of IgY in  simulated intestinal fluid probably due to hydrophobic interactions with the  polymer network. The stability of IgY in simulated gastric fluid was greatly improved  by encapsulation in hydrogels. This approach provides information about a novelty  method for delivery of IgY for the prevention and control of enteric diseases.","palabras_clave":"EGG YOLKS IMMUNOGLOBULINS|pH-RESPONSIVE HIDROGELS|DELIVERY|FTIR- SPECTROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17172,"idioma_id":4,"titulo":". Photothermal microscopy","resumen":"An accessory for a commercial optical microscope was implemented to map the thermal diffusivity of the sample with high spatial resolution. The system is based in the photothermal technique recently developed by the group. It consists in the measurement with a probe laser of the surface curvature induced by the heat delivered by a modulated pump laser. A lock-in detection technique provides the signal amplitude and phase as a function of the modulation frequency. The accessory was mounted on the camera port of a metallographic microscope Olympus BX51. Results obtained on different samples are presented.","palabras_clave":"PHOTOTHERMAL|NUCLEAR|FUEL|MICROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17173,"idioma_id":4,"titulo":"Androgen Deprivation and Cytoprotective Parameters in Rat Lung","resumen":"The aim was to study the effect of androgen deprivation, focusing on oxidative stress, and cytoprotective markers, in order to better understand the possible causes of pulmonary diseases in elder people. Adult male Wistar rats were divided into three groups: control (Co), a group subjected to castration by simple orchidectomy (Ca) and a group subjected to orchidectomy that received testosterone (100 &#956;g\/kg body weight) daily from day 25 to day 30 after castration (Ca + T). Bronchoalveolar lavages (BAL) and lungs were obtained. We observed a decrease in body weight in the castrated groups. Protein content in BAL was increased in both castrated groups while nitrites did not show differences among the groups. TBARS, Catalase (CAT) and Glutathione Peroxidase (GPx) activities were significantly increased in the castrated group, returning to the control values after the administration of testosterone. AR expression was increased in the castrated groups. Nrf-2 factor was increased in both castrated groups, while NADPH oxidase (NOX) and GPx expression increased in the Ca group but showed a decrease to control values in the Ca+T group. Superoxide Dismutase (SOD) did not show differences among the treatments. The immunohistochemistry showed a decreased expression of Hsp27 and increased expression of Hsp70 The absence of androgens induces oxidative stress in lung, together with changes in the expression of cytoprotective markers. This would lead to weak lung stroma, susceptible to undergo several pulmonary diseases.","palabras_clave":"pulmón |androgenos |hsp|morfología"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17174,"idioma_id":4,"titulo":"Preparation and characterization of polymorphs of the glucocorticoid deflazacort","resumen":"The polymorphism of new and old active pharmaceutical ingredients (APIs) is of great importance due to performance, stability and processability aspects. The objective of this study was to investigate the polymorphism of deflazacort (DEF), a glucocorticoid discovered >40&#8201;years ago, since this phenomenon has not been previously investigated for this API. Using different methods for solid form screening, it was determined for the first time that DEF is able to exist as three forms: a crystalline (DEF-1); a hydrated X-ray amorphous (DEF-t-bw) and an anhydrous amorphous phase (DEF-g) obtained from manually grinding DEF-1. The in vitro and in vivo dissolution rates (DRs) of DEF-1 and DEF-t-bw, which were measured using the rotating disk method in water at 37&#8201;°C and the pellet implantation technique in rats, respectively, indicated that DEF-t-bw exhibited slightly faster in vitro and in vivo DRs than those of the crystalline form, but the values were not significantly different. In addition, it was determined that DEF-t-bw devitrifies to DEF-1 by the effect of pressure, humidity and heat. It was concluded that DEF is glucorticoid with low tendency to exhibit different crystalline forms and that DEF-t-bw has no advantages over DEF-1 in terms of solubility, DRs and solid-state stability.","palabras_clave":"CRYSTALLIZATION|DEFLAZACORT|POLYMORPHISM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17175,"idioma_id":4,"titulo":"A SAXS Study of  PHB\/DGEBA Blends Crystallized at Different Temperatures","resumen":"A small-angle X-ray scattering (SAXS) study of blends of poly-3-hydroxybutyrate (PHB)\/diglycidyl ether of bisphenol A (DGEBA) with weight ratios of 90\/10, 70\/30 and 50\/50 and PHB isothermally crystallized at temperatures between 60ºC and 120ºC for one hour was performed. PHB was studied at different temperatures between 30ºC and 140ºC. The scattering curve results (intensity as a function of scattering vector (q)) indicated a main peak and secondary peaks associated with the thickness of the lamellae of PHB (with a strong tendency to crystallization). The position of the main peak decreased when the temperature was increased. At high temperatures (~120ºC), a deformation was observed in the main peak and a secondary peak was superimposed. This secondary peak was associated with the lamellar structures formed during the re-crystallization process. The results are discussed based on the DGEBA inclusion in the blends, crystallization temperature and partial interlamellar segregation.","palabras_clave":"POLYMERIC BLENDS|PHB|SAXS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17176,"idioma_id":4,"titulo":"Assessing advantages of Sequential Boron Neutron Capture Therapy (BNCT) in an oral cancer model with normalized blood vessels","resumen":"BACKGROUND: We previously demonstrated the therapeutic success of sequential boron neutron capture therapy (Seq-BNCT) in the hamster cheek pouch oral cancer model. It consists of BPA-BNCT followed by GB-10-BNCT 24 or 48 hours later. Additionally, we proved that tumor blood vessel normalization with thalidomide prior to BPA-BNCT improves tumor control. The aim of the present study was to evaluate the therapeutic efficacy and explore potential boron microdistribution changes in Seq-BNCT preceded by tumor blood vessel normalization.MATERIAL AND METHODS:Tumor bearing animals were treated with thalidomide for tumor blood vessel normalization, followed by Seq-BNCT (Th+ Seq-BNCT) or Seq-Beam Only (Th+ Seq-BO) in the window of normalization. Boron microdistribution was assessed by neutron autoradiography.RESULTS:Th+ Seq-BNCT induced overall tumor response of 100%, with 87 (4)% complete tumor response. No cases of severe mucositis in dose-limiting precancerous tissue were observed. Differences in boron homogeneity between tumors pre-treated and not pre-treated with thalidomide were observed.CONCLUSION:Th+ Seq-BNCT achieved, for the first time, response in all treated tumors. Increased homogeneity in tumor boron microdistribution is associated to an improvement in tumor control.","palabras_clave":"Boron Neutron Capture Therapy |Seq-BNCT|oral cancer|autoradiography|blood vessel normalization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17178,"idioma_id":5,"titulo":"Incidencia de las metas de aprendizaje en estudiantes secundarios avanzados.","resumen":"Este artículo presenta resultados de una investigación transeccional descriptiva, sobre las metas de aprendizaje que eligen estudiantes secundarios avanzados. Se pretendió conocer y describir las elecciones motivacionales de alumnos en diferentes situaciones pedagógicas de aula. Los datos se obtuvieron implementando una Encuesta de Relatos Motivacionales, administrada a 126 alumnos de cuatro escuelas públicas de la ciudad de Río Cuarto, Argentina. Los resultados se sistematizaron mediante estadística descriptiva y muestran que: 1) la meta de ?aprendizaje? fue elegida principalmente, para describir las acciones más frecuentes orientadas a obtener mejores notas, y para la manera más adecuada de resolver una materia especialmente difícil; 2) la meta de ?no complicarse la vida? fue seleccionada para caracterizar el mejor modo de enfrentar los aprendizajes, y para describir el propio comportamiento dentro del aula; 3) la meta de la ?desesperanza aprendida? fue elegida para describir la historia más frecuente en clases, y para el mejor modo de revolver una asignatura particularmente fácil. Dichas metas aluden a motivos, intereses, razones, creencias y deseos que se proponen los alumnos para orientar su comportamiento dentro del aula, en tanto dicho espacio configura las elecciones que realizan los estudiantes en él. Ellos persiguen diversas metas en función de las condiciones contextuales pedagógicas, optando por distintos modos de relacionarse con las tareas y los contenidos de enseñanza. Por ello, el compromiso, la dedicación y las valoraciones que realizan los alumnos sobre su propio desempeño son altamente situacionales, dependiendo del propósito personal hacia el aprendizaje.","palabras_clave":"metas|aprendizaje|estudiantes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17179,"idioma_id":5,"titulo":"Perfil antropométrico en adultos del Noroeste argentino: comparación con una referencia internacional","resumen":"Desde una perspectiva bioantropológica las mediciones antropométricas en adultos son exhaustivamente utilizadas en la evaluación morfológica de poblaciones argentinas extintas. La mayoría de los estudios antropométricos en adultos argentinos contemporáneos se limitan a la evaluación de talla, peso e IMC. El objetivo de este trabajo fue evaluar el estado nutricional y describir y comparar el perfil antropométrico de adultos contemporáneos de las provincias de Catamarca y Jujuy, que integran el noroeste argentino (NOA), con una referencia internacional.  Los datos de peso, talla, perímetros (brazo, muslo, pierna, cintura) y pliegues (tríceps, subescapular) proceden de 881 individuos (526 mujeres; 355 varones) de 20-60 años de edad de distintas localidades de Catamarca y Jujuy. Se calcularon estadísticos descriptivos (media y DS) por sexo y dos grupos de edad: 20-39 y 40-60 años. Se utilizó la prueba t de Student para realizar comparaciones entre sexos y con la referencia correspondiente a adultos de EEUU de origen mexicano (CDC, 2003-2006). Se calcularon los percentilos con el método LMS. El estado nutricional se calculó por sexos y grupos de edad a través del índice de masa corporal. La muestra de adultos analizada presenta altas prevalencias de exceso de peso. En ambos sexos y grupos de edad los adultos del NOA presentaron valores significativamente inferiores a los de la referencia en todas las variables consideradas, excepto para peso y pliegues subcutáneos en varones de 40-60 años. No se han encontrado antecedentes antropométricos comparables semejantes para poblaciones argentinas y del NOA. El perfil antropométrico de adultos contemporáneos del NOA,  catamarqueños y jujeños,  difiere significativamente con respecto a la población de referencia con un origen étnico afín.","palabras_clave":"ADULTOS|NOROESTE ARGENTINO|PERÍMETROS|PLIEGUES|ANTROPOMETRÍA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17180,"idioma_id":4,"titulo":"Parameter Estimation in SAR Imagery using Stochastic Distances and Asymmetric Kernels","resumen":"In this paper we analyze several strategies for the estimation of the roughness parameter of the G0I distribution. It has been shown that this distribution is able to characterize a large number of targets in monopolarized SAR imagery, deserving the denomination of Universal Model. It is indexed by three parameters: the number of looks (which can be estimatedin the whole image), a scale parameter, and the roughness or texture parameter. The latter is closely related to the number of elementary backscatters in each pixel, one of the reasons for receiving attention in the literature. Although there are efforts in providing improved and robust estimates for such quantity, its dependable estimation still poses numerical problems in practice. We discuss estimators based on the minimization of stochastic distances between empirical and theoretical densities, and argue in favor of using an estimator based on the Triangular distance and asymmetric kernels built with Inverse Gaussian densities. We also provide new results regarding the heavytailedness of this distribution.","palabras_clave":"Feature extraction|image texture analysis|synthetic aperture radar"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17181,"idioma_id":4,"titulo":"LAMP technology: Rapid identification of Brucella and Mycobacterium avium subsp. paratuberculosis","resumen":"In this study, we developed new sets of primers to detect Brucella spp. and M. avium subsp. paratuberculosis (MAP) through isothermal amplification. We selected previously well-characterized target gene bscp 31 specific for Brucella spp. and IS900 for MAP. The limits of detection with the Loop-mediated isothermal amplification (LAMP) protocols described here were similar to those of conventional PCR targeting the same sequences. Hydroxy naphtol blue and SYBR GreenTM allowed direct naked eye detection with identical sensitivity than agarose gel electrophoresis. We included the LAMP based protocol in a rapid identification scheme of the respective pathogens and all tested isolates were correctly identified within 2-3 hours. In addition, both protocols were suitable to specifically identify the respective pathogens and in the case of Brucella, all the biovars tested. We can conclude that LAMP is a suitable tool to be applied as a rapid molecular typing tool shortening the time in the identification of insidious bacteria in low complexity laboratories, mainly in developing countries.","palabras_clave":"LOOP-MEDIATED ISOTHERMAL AMPLIFICATION|MOLECULAR TYPING|BRUCELLOSIS|PARATUBERCULOSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17182,"idioma_id":4,"titulo":"Population Structure and Genetic Diversity characterization  of a sunflower association mapping population using SSR and SNP markers","resumen":"Background  Argentina has a long tradition of sunflower breeding, and its germplasm is a valuable genetic resource worldwide. However, knowledge of the genetic constitution and variability levels of the Argentinean germplasm is still scarce, rendering the global map of cultivated sunflower diversity incomplete. In this study, 42 microsatellite loci and 384 single nucleotide polymorphisms (SNPs) were used to characterize the first association mapping population used for quantitative trait loci mapping in sunflower, along with a selection of allied open-pollinated and composite populations from the germplasm bank of the National Institute of Agricultural Technology of Argentina. The ability of different kinds of markers to assess genetic diversity and population structure was also evaluated.    Results  The analysis of polymorphism in the set of sunflower accessions studied here showed that both the microsatellites and SNP markers were informative for germplasm characterization, although to different extents. In general, the estimates of genetic variability were moderate. The average genetic diversity, as quantified by the expected heterozygosity, was 0.52 for SSR loci and 0.29 for SNPs. Within SSR markers, those derived from non-coding regions were able to capture higher levels of diversity than EST-SSR. A significant correlation was found between SSR and SNP- based genetic distances among accessions. Bayesian and multivariate methods were used to infer population structure. Evidence for the existence of three different genetic groups was found consistently across data sets (i.e., SSR, SNP and SSR&#8201;+&#8201;SNP), with the maintainer\/restorer status being the most prevalent characteristic associated with group delimitation.    Conclusion  The present study constitutes the first report comparing the performance of SSR and SNP markers for population genetics analysis in cultivated sunflower. We show that the SSR and SNP panels examined here, either used separately or in conjunction, allowed consistent estimations of genetic diversity and population structure in sunflower breeding materials. The generated knowledge about the levels of diversity and population structure of sunflower germplasm is an important contribution to this crop breeding and conservation.","palabras_clave":"Sunflower breeding|Genetic resources|SNP|Association mapping"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17183,"idioma_id":5,"titulo":"Expresión material de la interacción entre indígenas y criollos en un sitio funerario del siglo XIX de Norpatagonia (Sitio Chimpay, Río Negro)","resumen":"En este trabajo se presentan los resultados del análisis de un contexto funerario de fines del siglo XIX, procedente de la localidad de Chimpay (noreste de Patagonia, Argentina). En el sitio se hallaron restos humanos de dos individuos adultos, un hombre y una mujer, con un abundante y diverso acompañamiento funerario que incluía prendas, accesorios y otros materiales dejados junto a los cuerpos como ofrenda. El foco principal del trabajo está puesto en el estudio de estos materiales asociados a los cuerpos, algunos típicamente indígenas y otros característicos de la sociedad hispano-criolla. Sobre la base de esto se concluye que las personas enterradas tenían una posición social y\/o política de jerarquía. El hombre posiblemente se desempeñó como interlocutor indígena frente a las autoridades del gobierno nacional y, para ello, habría recibido algún cargo militar.","palabras_clave":"Arueología|Siglo XIX|Entierro doble"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17184,"idioma_id":4,"titulo":"Capillary electrophoresis to determine entrapment efficiency of a nanostructured lipid carrier loaded with piroxicam","resumen":"A simple and fast capillary electrophoresis method has been developed to determine the amount of piroxicam loaded in a drug delivery system based on nanostructured lipid carriers (NLC). The entrapment efficiency of the nanostructured lipid carrier was estimated by measuring the concentration of drug not entrapped in a suspension of NLC. The influence of different parameters on migration times, peak symmetry, efficiency and resolution was studied; these parameters included the pH of the electrophoretic buffer solution and the applied voltage. The piroxicam peak was obtained with a satisfactory resolution. The separation was carried out using a running buffer, which it is composed of 50 mmol L-1 ammonium acetate and 13.75 mmol L-1 ammonia at pH 9. The optimal voltage was 20kV and the cartridge temperature was 20°C. The corresponding calibration curve  was linear over the range of 2.7 ? 5.4 &#956;g mL-1 of NLC suspension. The reproducibility of migration time and peak area were investigated, and the obtained RSD% values (n = 5) were 0.99 and 2.13, respectively.","palabras_clave":"Capillary electrophoresis|Drug delivery system|Nanostructured lipid carrier|Piroxicam"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17185,"idioma_id":4,"titulo":"Identification of precipitates in weldments performed in an ASTM A335 Gr P91 steel by the FCAW process","resumen":"In order to increase the thermal efficiency of advanced power generation systems higher operation temperature and pressures  should be used. The P91 steel has excellent mechanical properties from room temperature up to approximately 600ºC due to a  distribution of a fine-sized Nb and V carbonitrides. In this context, special attention must be put on the welds. The failure of a  component may be initiated in a localized and microscopic region of the weldments, either during welding or in service. This is  due to the differences in the behaviour of the various regions of the weld because of the heterogeneity in its microstructure.  In the present work the characterization of precipitates in the fusion zone, heat affected zone and base material was performed on  a circumferential weldments by means of transmission electron microscopy. The weldments were obtained using a semiautomatic  welding process under gas mixture protection with two different filler materials.","palabras_clave":"9Cr1Mo steels|Welded joint|Electron microscopy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17187,"idioma_id":4,"titulo":"Evolution of minor phases in a P91 steel normalized and tempered at different temperatures","resumen":"The evolution of minor phases in ASTM A335 P91 steel has been studied on specimens submitted to different thermal treatments including a tempering step. Particular emphasis has been put on the tempering temperature range 573 K to 873 K (300 C to 600 C), which has not been yet intensively studied. The techniques used in this investigation were X-ray diffraction with synchrotron light, scanning electron microscopy with field emission gun and transmission electron microscopy. In the low tempering  temperature range [573 K to 673 K (300 C to 400 C)], retained austenite, Fe3C and MX precipitates are observed. In the high tempering temperature range [773 K to 1053 K (500 C to 780 C)], M23C6-type carbides, MX-type carbonitrides and M2X precipitates are observed. The effect of the microstructure on hydrogen trapping is analyzed. The distorted matrix around the M2X and MX particles provides the most important trap sites in the P91 steel.","palabras_clave":"9%Cr steel|Precipitates|Hydrogen trapping|Thermal treatments"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17188,"idioma_id":4,"titulo":"Reptiles of Chubut province, Argentina:  richness, diversity, conservation status  and geographic distribution maps","resumen":"An accurate estimation of species and population geographic ranges is essential for species-focused studies and conservation and management plans. Knowledge of the geographic distributions of reptiles from Patagonian Argentina is in general limited and dispersed over manuscripts from a wide variety of topics. We completed an extensive review of reptile species of central Patagonia (Argentina). We compiled and checked geographic distribution records from published literature and museum records, including extensive new data from the LJAMM-CNP (CENPAT-CONICET) herpetological collection. Our results show that there are 52 taxa recorded for this region and the highest species number were presented by Liolaemidae and Dipsadidae families, with 31 and 10 species respectively. The Provincia Patagónica was the phytogeographic province most diverse in species and Phymaturus was the genus most committed to its conservation status. We present a detailed species list with geographical information, richness species, diversity analyses with comparisons across phytogeographical provinces, conservation status, taxonomic comments and distribution maps for all of these taxa.","palabras_clave":"BIOGEOGRAPHY|DIVERSITY|HERPETOFAUNA|CONSERVATION|CENTRAL PATAGONIA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17189,"idioma_id":4,"titulo":"Association of cholesteryl ester transfer protein genotypes with paraoxonase-1 activity, lipid profile and oxidative stress in type 2 diabetes mellitus: A study in San Luis, Argentina","resumen":"Aims\/Introduction: Diabetic dyslipidemia is common in type 2 diabetes. The TaqIB polymorphism in cholesteryl ester transfer protein (CETP; B1 and B2 alleles; rs708272) is associated with changes in enzyme activity and lipid concentrations. The aim of the present study was to assess associations of CETP genotypes with lipoprotein profile, oxidant\/anti-oxidant status and the plasma activity of paraoxonase-1 (PON-1) in a population of diabetic patients living in San Luis, Argentina.    Materials and Methods: For oxidative stress status parameters, thiobarbituric acid-reactive substances (TBARS) and nitric oxide (NO) levels, and catalase and PON-1 activity were assessed in 40 patients with type 2 diabetes mellitus and 30 healthy participants. CETP polymorphism was analyzed by polymerase chain reaction-based methods.  Results: Type 2 diabetes mellitus had significantly higher concentrations of oxidative stress parameters: TBARS (P < 0.0001) and catalase activity (P < 0.0001). PON-1 activity and NO levels were significantly lower in diabetics (P = 0.0002 and P = 0.0008, respectively). The CETP genotypes distribution among study groups was not significantly different. The B2 carriers of the TaqIB CETP polymorphism are associated with higher high-density lipoprotein cholesterol levels and PON-1 activity in control and type 2 diabetes mellitus patients. Linear regression analysis showed that there was a significant and positive correlation between the changes of PON-1 activity and high-density lipoprotein cholesterol levels in non-B1B1 (B2 carriers) in controls (r = 0.83, P < 0.0001) and diabetic patients (r = 0.39, P = 0.0003).  Conclusions: The results of the current study show that type 2 diabetes mellitus is characterized by intense oxidative stress, and that the alterations observed in the lipoprotein profile and PON-1 activity might be related to the higher CETP activity in diabetic patients as a consequence of insulin resistance.","palabras_clave":"TYPE 2 DIABETES MELLITUS|POLYMORPHISM|CETP|OXIDATIVE STRESS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17190,"idioma_id":5,"titulo":"Canteras-taller de cuarzo y un análisis de los conjuntos artefactuales del sitio Piedra Blanca (Copacabana, Córdoba)","resumen":"CANTERAS-TALLERDE CUARZO Y UN ANÁLISIS DE LOS CONJUNTOS ARTEFACTUALES DEL SITIO PIEDRA BLANCA(COPACABANA, CÓRDOBA)QUARTZ QUARRIES AND ANALYSIS OF ARTIFACTS FROM PIEDRABLANCA SITE (COPACABANA, CORDOBA)&nbsp;Gisela Sario[1] yEduardo Pautassi[2]&nbsp;RESUMENEl cuarzo es lamateria prima predominante en la mayoría de los sitios arqueológicos de laregión de Sierras Centrales, pero también aparece en otros sitios de Argentina,a veces en proporciones menores. En este artículo presentamos un análisistecno-tipológico de los productos de talla de cuarzo de un sitio cantera-tallerubicado en el Valle de Copacabana, en el norte de Córdoba. El objetivo centrales dar a conocer las características de estos artefactos, que no siempre hansido reconocidos fácilmente sus atributos, ya que es una materia prima queposee una mecánica de fractura particular. Entre los resultados alcanzadosencontramos una amplia variedad artefactual, un alto porcentaje de desechosindiferenciados y un menor porcentaje de productos de talla bipolar.Palabras clave: Canteras-taller,tecnología lítica, cuarzo, Sierras Centrales[1]IDACOR-CONICET\/Museo de Antropología (FFyH, UNC),Av. Hipólito Irigoyen 174, Córdoba (5000) \/mail: giselasario@hotmail.com[2]Museo de Antropología (FFyH, UNC),Av. Hipólito Irigoyen 174, Córdoba (5000) \/mail: e_pautassi@yahoo.com.ar","palabras_clave":"Canteras-taller, |tecnología lítica,| cuarzo|Sierras Centrales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17191,"idioma_id":4,"titulo":"Hybrid vision-based navigation for mobile robots in mixed indoor\/outdoor environments","resumen":"In this paper we present a vision-based navigation system for mobile robots equipped with a single, off-the-shelf camera in mixed indoor\/outdoor environments. A hybrid approach is proposed, based on the teach-and-replay technique, which combines a path-following and a feature-based navigation algorithm. We describe the navigation algorithms and show that both of them correct the robot?s lateral displacement from the intended path. After that, we claim that even though neither of the methods explicitly estimates the robot position, the heading corrections themselves keep the robot position error bound. We show that combination of the methods outperforms the pure feature-based approach in terms of localization precision and that this combination reduces map size and simplifies the learning phase. Experiments in mixed indoor\/outdoor environments were carried out with a wheeled and a tracked mobile robots in order to demonstrate the validity and the benefits of the hybrid approach.","palabras_clave":"Robot vision|Hybrid navigation|Indoor\/outdoor environments"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17192,"idioma_id":4,"titulo":"Canker Control by the Siderophore Pyochelin from Pseudomonas fluorescens","resumen":"This work shows the identification of a compound able to inhibit Xanthomonas citri subsp. citri (citrus canker agent) growth in vitro and in vivo. Firstly, we isolated from citrus leaves surfaces, bacteria able to inhibit X. citri subsp. citri in vitro. Among the selected isolates, we focused in one showing a remarkable activity. The strain was characterized as Pseudomonas fluorescens after sequencing its 16S rDNA and analyzing the sequence with BLASTn. Purification and chemical analysis of the active compound allowed us to assign the inhibitory activity to enantio-pyochelin (E-Pch). Since this molecule is a siderophore, we wondered if the inhibition observed was a result of iron scavenging. Surprisingly, when we supplemented media with an excess of iron, we observed practically no change in the inhibition activity. In an attempt to identify the action mechanism of E-Pch, we evaluated the ability of E-Pch to generate reactive oxygen species (ROS) within a culture of X. citri subsp. citri and its correlation with the inhibitory activity. In fact, we observed increased ROS levels when E-Pch was added. In addition, the reducer agent ascorbic acid, lowered ROS levels and the antibiotic activity, implying that inhibition is probably caused by oxidative stress. Finally, we studied the use of E-Pch in a model of canker disease. E-Pch showed to reduce canker formation on leaves of Eureka and Lisbon lemon cultivars. These results show E-Pch as a promising compound for citrus canker biocontrol.","palabras_clave":"Pyochelin|Canker|Pseudomonas fluorescens"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17193,"idioma_id":4,"titulo":"Radicalization of Glyceraldehyde-3-Phosphate Dehydrogenase by HOCl in  Living Cells","resumen":"A number of post-translational oxidative modifications of the enzyme ?cell-redox sensor? glyceraldehyde-3- phosphate dehydrogenase (GAPDH) have been reported. These modifications affect GAPDH structure, function, and cell fate; however no free-radical mechanisms have been reported in these processes. Herein we used the nitrone 5,5-dimethyl-1-pyrroline N-oxide (DMPO)-based spin trapping techniques to examine a novel free radical mechanism that causes GAPDH inactivation and aggregation in RAW264.7 cells primed with lipopolysaccharide (LPS). In these primed cells, GAPDH is oxidized by myeloperoxidase (MPO)-derived hypochlorous acid (HOCl) resulting in loss of enzyme activity and aggregation, accumulation of lactate and cell death. Due to the close spatial and physical proximity between MPO and GAPDH, and the oxidizing potential of HOCl, it may be the main species that triggers radicalization of GAPDH that ultimately results in enzyme aggregation and inactivation in LPS-primed macrophages. Lysine residues are the primary radicalization sites formed upon reaction of HOCl with the enzyme. Our data highlight the important relationship between radicalization of GAPDH and fate of stressed cells, which might help teasing out the cell response to stress at sites of inflammation.","palabras_clave":"GAPDH|LIPOPOLYSACCHARIDE|FREE RADICAL|DMPO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17194,"idioma_id":4,"titulo":"COMPARING NITRATE-N LOSSES THROUGH LEACHING BY FIELD MEASUREMENTS AND NITROGEN BALANCE ESTIMATIONS","resumen":"Nitrogen (N) balance method is a valuable tool for estimating N losses. However, this technique could lead to incorrect estimates of the amount of nitrate (NO3&#8722;N) leaching if processes relevant to N losses are not considered properly. The aim of this study was to compare NO3&#8722;-N leaching losses estimated using an N balance (nonrecovered N, Nne) with data of NO3&#8722;-N leaching losses (Nl). The experiment was made on a Typic Argiudoll soil planted with corn (five growing seasons) under 0, 100, and 200&nbsp;kg&nbsp;N&nbsp;ha&#8722;1. The ceramic soil-water suction samplers were installed (1&nbsp;m deep). Drainage was estimated by the LEACH-W model. The greatest overestimation with the N balance method occurred for years with annual rainfall below the historical average and at times of high NO3&#8722;-N availability. Future research should focus on investigating mechanisms of N losses relevant under limited water availability.","palabras_clave":"Nitrogen, |nutrient cycling, |water quality"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17196,"idioma_id":4,"titulo":"Hydrological change during the Pleistocene-Holocene transition associated with the Last Glacial Maximum-Altithermal in the eastern border of northern Puna","resumen":"The environmental conditions of the Andean Puna Plateau are mostly characterized by the dominance of evaporative processes due to aridic conditions. Since the intermittent runoff lacks the morphodynamic competence to generate the current landscape, authors usually considered that the Puna?s landscape is a remnant feature of the Miocene arid-climate persistence, and assigned a Quaternary-sensu lato-age of salars, alluvial fans and other geomorphologies.  We present evidences from the endorheic depression of Guayatayoc-Salinas Grandes, located at 3400 msnm on the eastern border of the North Puna of Argentina. The basin includes a saline playa domain in the north (Guayatayoc playa lake) and a salt pan in the southern part (Salinas Grandes), which are related to processes originating the subdivision of the GSG depression. The characterization of those processes includes sedimentological and geomorphological observations, as well as chronologies using luminescence and radiocarbon.  Evidences reveal the development of lacustrine water bodies which are associated to the Last Glacial Maximum. During the Late Pleistocene and until ~13800 yr cal BP, lake shores were modeled on the front of distal-alluvial fans, the sedimentary aggradation was widespread, and associated to kaolinitic-clay accumulation, inyoite, and the formation of peat-deposits. An  2  environmental change towards aridic conditions was recorded after 9000 yr cal BP. Incisive dynamics accompanied the establishment of the playa lake, with montmorillonitic-fine sediments generation and ulexite. The subdivision of the GSG depression onset by two processes, the topographic decoupling, associated with Las Burras?s alluvial fan aggradation, and the lacustrine regression phase during the post Last Glacial Maximum. Therefore, Guayatayoc and Salinas Grandes are saline systems functioning as a playa lake and a salt pan, respectively, since Middle Holocene, and its genesis resulted from environmental constraints.","palabras_clave":"Holocene|Pleistocene|Paleoclima|Puna"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17197,"idioma_id":4,"titulo":"Existence of optimal subspaces in reflexive Banach spaces","resumen":"Given a finite set $Y$ in a  reflexive Banach space $F$ and a family  $mathcal{C}$ of closed subspaces of $F$, we study the problem of  finding a subspace $V_0$ in $mathcal{C}$ that best approximates the  data $Y$ in the sense that $sum_{f in Y} d(f,V_0)= min_{V in  mathcal{C} }sum_{f in Y} d(f,V)$, where $d$ is the distance  function on $F$. In this paper, we give necessary conditions and  sufficient conditions over $mathcal{C}$ for which such a best  approximation exists. In particular, when $F$ has finite dimension a  characterization on $mathcal{C}$ is given.","palabras_clave":"OPTIMAL SUBSPACES|EXISTENCE|REFLEXIVE BANACH SPACE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17198,"idioma_id":4,"titulo":"Risk factors for work-related injury among farm workers: A one-year study","resumen":"A one-year  prospective survey was conducted to study the incidence of potential risk  factors of farm-related injuries in Egusquiza, Santa Fe (Argentina). Farm  workers were surveyed using a personal interview (N=110, n= 78). Information on  demographic characteristics and occupational accidents was collected. Monthly  telephone contact was then maintained with the workers for one year in order to  document all farm-related injuries. Data analysis included incidence rate, ÷2 and logistic regression. Sixty-nine  farm-related injuries were reported during the study period, being six the  maximum number of injuries affecting one worker. Forty-six point three percent  of the workers suffered at least one injury during the year. The incidence rate  was 7.5 injuries\/ 100 individual-month at risk. Medical assistance was  necessary in 26.8% of the cases and 5.8% of the injuries caused at least one  day off work. Hospitalization for at least one day was required by 2.9% of the  injured workers. Previous work injury in the family (P= 0.005) (OR= 4.6)  and worker?s activity (P= 0.021) (OR= 3.7) were associated with the  dependent variable work injury. Workers with previous work injury in the family  injured themselves four times more than those without (IC95%= 1.6 ? 13.3).  Owners got injured almost four times more than the other workers (IC95%= 1.2 ?  11.6). Agricultural and livestock farming are productions of great importance  for national economy. It is necessary to invest on training farm workers about  farm safety practices. This would help prevent farm-related injuries and  professional illnesses.","palabras_clave":"Farm-workers|Injuries|Risk factors"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17199,"idioma_id":4,"titulo":"Feasibility and Effort Estimation Models for Medium and Small Size Information Mining Projects","resumen":"Information mining is a sub-discipline of Information Systems which provides the non-trivial knowledge needed for making decisions inside an organization. Although such projects have different features from Software Engineering ones, they share some of their problems. Among these problems two are highlighted: unmanaged risks and inaccurate estimations of necessary resources to complete the project. In this context, this paper presents two ad-hoc models to be applied in Small and Medium-sized Enterprises: one for assessing project feasibility and the other for estimating the resources and time required to carry out the project. Both models should be applied at the beginning of the project.","palabras_clave":"Data Mining|Effort Estimation Model|Feasibility Model|SMEs"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17200,"idioma_id":4,"titulo":"Development of quality index method (QIM) scheme for common carp (Cyprinus carpio) stored in ice. Shelf life assessment by physico-chemical, microbiological and sensory quality indices.","resumen":"Sensory methods are the most interesting methods to estimate fish quality. Among these, the recently developed quality index method (QIM) has gained popularity, as shown by the multiple publications of QIM schemes in the last years. The objective of this study was to create a new QIM scheme (QIM sensory table and corresponding point system) for the common carp (Cyprinus carpio), basing the definition of the rejection point on sensory, physicochemical (thiobarbituric acid reactive substances, total volatile basic nitrogen, pH, and color measurements), and microbiological criteria (counts of mesophiles, psychrotrophs, and Pseudomonas spp.). A new QIM scheme was developed and is proposed for use in the future; it will be useful for practical evaluations of carp freshness in all steps of the production chain, and it will contribute to a more effective use of the species as an alternative for human food supply.","palabras_clave":"COMMON CARP|CYPRINUS CARPIO|QUALITY INDEX METHOD|SHELF LIFE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17201,"idioma_id":4,"titulo":"Litterfall and nutrients return in Nothofagus antarctica forests growing in a site quality gradient with different management uses in Southern Patagonia","resumen":"Se discute la dinámica de nutrientes de la hojarasca en un bosque de ñire con y sin manejo silvopastoril y de dos clases de sitio diferentes.","palabras_clave":"litterfall|nutrients return|Nothofagus antarctica|site quality|management"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17202,"idioma_id":4,"titulo":"Size and surface effects in the magnetic order of CoFe2O4 nanoparticles","resumen":"In this work,we have focused on the size dependence of the magnetic properties and the surface effects of CoFe2O4 nanoparticles synthesized by high-temperature chemical method with diameter d = 2, 4.5 and 7nm, with narrow size distribution. Transmission electron microscopy (TEM) images and X-ray diffraction (XRD) profiles indicates that samples with 7 and 4.5 nm presenta high crystallinity while the 2 nm sample has a poor one. We have investigated by magnetization measurements and in-field Mössbauer spectroscopy the influence of the surface in the internal magnetic order of the particles. Particles with d = 7 nm have almost single domain behavior and the monodomain occupies approximately the whole particle. In the sample with d=4.5 nm the surface anisotropy is large enough to alter the ferrimagnetic order in the particle shell. Then, a surface\/volume ratio of 60% is the crossover between a single domain nanoparticle and a frustrated order in a magnetic core?shell structure,due to the competition between surface anisotropy and exchange interaction with the crystalline anisotropy in cobalt ferrite. In the d = 2 nm sample the poor crystallinity and the large surface\/volume ratio avoid the ferrimagnetic order in the particle down to T=5 K.","palabras_clave":"MAGNETIC NANOPARTICLES|SIZE EFFECTS|MAGNETIC ORDER|EFFECTIVE ANISOTROPY|COBALT FERRITE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17203,"idioma_id":4,"titulo":"Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome","resumen":"SPOAN syndrome is a neurodegenerative disorder mainly characterized by spastic paraplegia, optic atrophy and neuropathy. Affected patients are wheelchair bound after 15 years old, with progressive joint contractures and spine deformities. SPOAN patients also have sub normal vision secondary to apparently non-progressive congenital optic atrophy. A potential causative gene was mapped at 11q13 ten years ago. Here we performed next-generation sequencing in SPOAN-derived samples. While whole-exome sequencing failed to identify the causative mutation, whole-genome sequencing allowed to detect a homozygous 216-bp deletion (chr11.hg19:g.66,024,557_66,024,773del) located at the non-coding upstream region of the KLC2 gene. Expression assays performed with patient´s fibroblasts and motor neurons derived from SPOAN patients showed KLC2 overexpression. Luciferase assay in constructs with 216-bp deletion confirmed the overexpression of gene reporter, varying from 48 to 74%, as compared to wild-type. Knockdown and overexpression of klc2 in Danio rerio revealed mild to severe curly-tail phenotype, which is suggestive of a neuromuscular disorder. Overexpression of a gene caused by a small deletion in the non-coding region is a novel mechanism, which to the best of our knowledge, was never reported before in a recessive condition. Although the molecular mechanism of KLC2 up-regulation still remains to be uncovered, such example adds to the importance of non-coding regions in human pathology.","palabras_clave":"SPOAN syndrome|KLC2"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17204,"idioma_id":5,"titulo":"La perspectiva objetiva y subjetiva en el diagnóstico de acoso en el trabajo","resumen":"A un colectivo de 1902 trabajadores de organizaciones públicas y privadas de Argentina, se ha administrado el Cuestionario de Estilos, Modalidades y Tipos de Acoso Laboral (CEMTAL) que incluye una dimensión individual, con una serie de ítems con formato tipo Likert organizados de acuerdo con un modelo teórico según el cual el Acoso está compuesto por 5 factores estructurales (Relacionalidad Intrusividad, Descalificación, Acatamiento Normativo y Contacto Físico\/Sexual) y una escala de Efectos sintomatológicos. Todos los factores mostraron una alta consistencia interna, con valores &#945; de Cronbach comprendidos entre .67 (Contacto Físico\/Sexual) y .88 (Intrusividad). Además, el cuestionario cuenta con una dimensión organizacional compuesta por cuatro escalas creadas ad hoc para evaluar ese aspecto. Los resultados indican que el CEMTAL reproduce fielmente la estructura del modelo teórico propuesto. Además, no solo evalúa el Acoso Laboral desde un doble enfoque (objetivo- subjetivo) sino que complementa la perspectiva individual con una organizacional.","palabras_clave":"METODOGÍA|CRITERIO OBJETIVO|CRITERIO SUBJETIVO|ACOSO LABORAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17205,"idioma_id":4,"titulo":"Tyrosine 251 at the C-terminus of Neuronal Glycoprotein M6a is Critical for Neurite Outgrowth.","resumen":"Neuronal glycoprotein M6a is involved in neuronal plasticity, promoting neurite and filopodia outgrowth and, likely, synaptogenesis. Polymorphisms in the human M6a gene GPM6A have recently been associated with mental illnesses such as schizophrenia, bipolar disorders, and claustrophobia. Nevertheless, the molecular bases underlying these observations remain unknown. We have previously documented that, to induce filopodia formation, M6a depends on the association of membrane lipid microdomains and the activation of Src and mitogen-activated protein kinase kinases. Here, in silico analysis of the phosphorylation of tyrosine 251 (Y251) at the C-terminus of M6a showed that it could be a target of Src kinases. We examined whether phosphorylation of M6a at Y251 affects neurite and filopodia outgrowth and the targets involved in its signal propagation. This work provides evidence that the Src kinase family and the phosphatidylinositide 3-kinase (PI3K), but not Ras, participate in M6a signal cascade leading to neurite\/filopodia outgrowth in hippocampal neurons and murine neuroblastoma N2a cells. Phosphorylation of M6a at Y251 is essential only for neurite outgrowth by the PI3K\/AKT-mediated pathway and, moreover, rescues the inhibition caused by selective Src inhibitor and external M6a monoclonal antibody treatment. Thus, we suggest that phosphorylation of M6a at Y251 is critical for a specific stage of neuronal development and triggers redundant signaling pathways leading to neurite extension.","palabras_clave":"PI3K kinase|Src family of kinases| filopodia formation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17206,"idioma_id":4,"titulo":"Social Perceptions About Community Life with People with Mental Illness: Study of a Discharge Program in Buenos Aires Province, Argentina","resumen":"Effects of living near people with mental illness in community settings have been researched as part of psychiatric reform evaluation. However, these studies have been carried out mostly in industrialized countries, where social contexts differ from those in which psychiatric reform is now being implemented. To analyze the effects of community life with people with mental illness in the neighborhoods in which they live, in Buenos Aires, Argentina. A questionnaire was administered to randomly-selected neighbors of group homes of a discharge program and an equivalent control area (n = 236). Data was analyzed both quantitatively and qualitatively. Significant differences were found between being a neighbor and having a high degree of acceptance toward people with mental illness. In addition, significant associations were found between neighbors having a high-perceived social cohesion and having a high level of acceptance toward the mentally ill. Living near people with mental illness is associated with better acceptance toward them; these results are congruent with those results found in other cultural contexts.","palabras_clave":"COMMUNITY INTEGRATION|MENTALLY ILL PERSONS|SOCIAL PERCEPTION|COMMUNITY MENTAL HEALTH SERVICES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17207,"idioma_id":4,"titulo":"Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance","resumen":"Membrane overexpression of ErbB-2\/HER2 receptor tyrosine kinase (membrane ErbB-2 (MErbB-2)) has a critical role in breast cancer  (BC). We and others have also shown the role of nuclear ErbB-2 (NErbB-2) in BC, whose presence we identified as a poor prognostic  factor in MErbB-2-positive tumors. Current anti-ErbB-2 therapies, as with the antibody trastuzumab (Ttzm), target only MErbB-2.  Here, we found that blockade of NErbB-2 action abrogates growth of BC cells, sensitive and resistant to Ttzm, in a scenario in which  ErbB-2, ErbB-3 and Akt are phosphorylated, and ErbB-2\/ErbB-3 dimers are formed. Also, inhibition of NErbB-2 presence suppresses  growth of a preclinical BC model resistant to Ttzm. We showed that at the cyclin D1 promoter, ErbB-2 assembles a transcriptional  complex with Stat3 (signal transducer and activator of transcription 3) and ErbB-3, another member of the ErbB family, which  reveals the first nuclear function of ErbB-2\/ErbB-3 dimer. We identified NErbB-2 as the major proliferation driver in Ttzm-resistant  BC, and demonstrated that Ttzm inability to disrupt the Stat3\/ErbB-2\/ErbB-3 complex underlies its failure to inhibit growth.  Furthermore, our results in the clinic revealed that nuclear interaction between ErbB-2 and Stat3 correlates with poor overall  survival in primary breast tumors. Our findings challenge the paradigm of anti-ErbB-2 drug design and highlight NErbB-2 as a novel  target to overcome Ttzm resistance.","palabras_clave":"ErbB-2|trastuzumab|breast cancer"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17208,"idioma_id":4,"titulo":"Azospirillum brasilense enhances in vitro rhizogenesis of Handroanthus impetiginosus (pink lapacho) in different culture media","resumen":"ContextHandroanthus impetiginosus is an ornamental tree used in urban forestry programs and landscaping, produces good timber, and has medicinal qualities. Clearing of natural forest has been increased and motivates to find techniques that optimize rhizogenesis to ex situ conservation and reforestation.Aims:This study evaluated Azospirillum brasilense as an enhancer of in vitro rooting of H. impetiginosus under different indole-3-butyric acid (IBA) pulse inductions and media formulations.MethodsIn vitro shoots were induced with 0 to 50-&#956;M IBA pulse for 3 days, transferred to two half-strength media (Murashige and Skoog salts with Gamborg?s vitamins [MSG] and woody plant medium), and inoculated or not with A. brasilense Cd or Az39 strains.ResultsThe statistic response surface methodology determined that both A. brasilense strains decreased auxin requirement for rooting up to 49 % in half-strength MSG. In this medium, Cd strain with 30-&#956;M IBA pulse produced the 98 % of rooting shoots 21 days before uninoculated plants induced with the same IBA pulse. Also, the biometric parameter index increased from 127 to 286 % in shoots inoculated and induced with 0 to 30 &#956;M IBA, relative to uninoculated.ConclusionOur results show that biofertilization with A. brasilense significantly promotes in vitro rooting of H. impetiginosus decreasing auxin requirements and micropropagation costs.","palabras_clave":"AZOSPIRILLUM BRASILENSE|IN VITRO CULTURE|LAPACHO|ROOTING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17209,"idioma_id":5,"titulo":"Integración de líneas de investigación sobre eficiencia energética en edificios (2000-2014) en la cátedra Estructuras II - FAU - UNNE","resumen":"Desde el año 2000 al presente año 2014 la asignatura ESTRUCTURAS II-FAU-UNNE ejecuta actividades de investigación aplicada, además de las actividades própias en docencia universitaria. El campo de trabajo de las actividades de investigación se organizan dentro de las temáticas relacionadas con el uso racional de la energía en la edificación.","palabras_clave":"ENERGÍA|MEDIOAMBIENTE|TECNOLOGÍA DE LA CONSTRUCCIÓN|ARQUITECTURA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17210,"idioma_id":4,"titulo":"Phase transition, dielectric and piezoelectric properties of LixK1\u0002xNbO3","resumen":"The influence of Li impurities on the phase transition, dielectric and piezoelectric properties of KNbO3 ceramics is investigated. We found that Li doping alters the transition temperatures of KNbO3. While the temperature for the orthorhombic?tetragonal phase transition decreases, the temperature of the cubic?tetragonal ferroelectric phase transition increases. The dielectric and piezoelectric properties of the ceramics are improved by the addition of Li. The experiments were contrasted and complemented with first-principles-based atomic level simulations to gain more insight into the intrinsic properties of the solid solution. We show that the impurities improve the dielectric properties due to a relaxational contribution of the off-center Li ions. The increase of the piezoelectric response is associated to the concentration dependence of the shear piezoelectric coefficients.","palabras_clave":"Ferroelectrics |Perovskites |Atomistic simulations"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17211,"idioma_id":4,"titulo":"Pd Nucleation and Growth Mechanism Deposited on Different Substrates","resumen":"Palladium, has an unique property between the noble metals, that is the higher capacity to adsorb onto the surface, and within its network, the hydrogen, resulting the Pd of crucial importance to many industrial processes such as catalysis, fuel cell, hydrogen storage and metal brittlement. Since the activity of a noble metal deposited depends strongly on the surface structure, this work is focalized to study the Pd° nucleation and growth mechanisms onto different substrates such as HOPG, and thin pure titanium films. Thus, the constant potential method was used in the nanostructures formation varying the potentials and times. The resulting material was characterized electrochemically and morphologically using scanning electron microscopy (SEM), X-ray diffraction (XRD). In agreement with the results, the existing mechanism onto both substrates, was (3D) Pd ° instantaneous nucleation and growth controlled by diffusion, with a development of nanoparticles with defined morphology and narrow size distributions, which are potentially useful as electrocatalysts","palabras_clave":"Electrodeposition|Palladium|Nucleation|growth models"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17212,"idioma_id":5,"titulo":"Aulas-laboratorios de bajo costo, usando TIC","resumen":"En este trabajo se presentan los resultados de una propuesta educativa orientada a promover el desarrollo de un pensamiento crítico y un mayor interés por las ciencias experimentales. Con este fin desarrollamos propuestas de proyectos educativos susceptibles de ser destinadas a las aulas y laboratorios de las escuelas secundarias y primeros años de la universidad, que resaltan los aspectos metodológicos de las ciencias. Aquí, presentamos un de proyectos que se pueden utilizar para implementar un aula-laboratorio de bajo costo. Los proyectos intentan integrar áreas como física, matemática, química, informática, arte, etc. y apuntan a que los estudiantes puedan responder a las preguntas: ¿Cómo sabemos esto?, ¿Por qué creemos en aquello? Preguntas que ilustran la naturaleza del pensamiento científico. Nuestra contribución más significativa es haber desarrollado ?aulas-laboratorios? de muy bajo costo, usando TIC.","palabras_clave":"Enseñanza de las Ciencias|Laboratorios de Bajo Costo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17213,"idioma_id":4,"titulo":"Application of digital images to determine color in honey samples from Argentina","resumen":"Honey color is the first quality attribute evaluated by consumers and is an important sensory property in the beekeeping market. The most commonly used method for color determination is based on optical comparison, employing a Pfund colorimeter. This method is laborious, time consuming and is based on a subjective assessment. In order to obtain a fast and objective measurement of honey color, an analytical method based on digital images analysis combined with multivariate calibration (Partial Least Squares) was developed. Three color models, RGB (red?green?blue), HSB (hue?saturation?brightness) and Grayscale, were used to analyze the digital images. The optimum results were obtained by using HSB color model (r2 = 0.97 and RMSEP = 2.46), indicating that the digital image analysis combined with multivariate calibration is an excellent strategy for quantifying color in honey samples.","palabras_clave":"HONEY|COLOR|DIGITAL IMAGE|MULTIVARITE CALIBRATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17214,"idioma_id":4,"titulo":"Effects of 3-methyladenine on isolated left atria subjected to simulated ischaemia-reperfusion","resumen":"se adjunta en el pdf.","palabras_clave":"ISQUEMIA|REPERFUSION|AURICULA|3-METILADENINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17215,"idioma_id":4,"titulo":"Biochemical characterization of the flavedo of heat treated Valencia orange during postharvest cold storage","resumen":"Heat treatment is a powerful and eco-friendly method to prevent Penicillium infection in citrus fruit during the postharvest. Several studies have been dedicated to investigate the general chemical changes that justify the immediate reaction responsible for the induced tolerance; but just how primary metabolism and enzymology are affected by heat treatment and along a prolonged cold storage is still unclear. In this work, the main enzymes of carbon metabolism of Valencia orange flavedo were analyzed during the postharvest period after a heat treatment (HT) of 48 h at 37 ºC. Enzymatic activity measurements indicated that the NADPH producing enzymes glucose 6-phosphate dehydrogenase and non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase have lower levels in HT fruit. In parallel, a higher synthesis of sucrose from organic acids was observed in HT epicarp. Sucrose-phosphate synthase would have an important role in sucrose accumulation. The pathway of carbon through glycolysis was affected by cold storage, independently of HT, in a way that it favors the ATP-dependent phosphofructokinase over the PPi-dependent homologous enzyme and the use of phosphoenolpyruvate (PEP) by PEP carboxylase instead of pyruvate kinase. Similarly, phenylpropanoid compounds did not show major changes in response to HT, although some of them showed a marked descent along the cold storage. Proteomic studies revealed alterations in the abundance of ascorbate peroxidase, two germin-like proteins and small HSPs, completing the description of the main metabolic changes in this tissue.","palabras_clave":"Citrus fruit|Glycolysis|Fruit biochemistry|Orange"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17216,"idioma_id":4,"titulo":"Decision tree analysis for the determination of relevant variables and quantifiable reference points to establish maturity stages in Enteroctopus megalocyathus and Illex argentinus","resumen":"Determining the maturity condition of a large number of individuals is crucial for stock assessment and management of cephalopod populations, but this task is difficult to conduct in practice. We propose a novel approach for maturity stage classification using observer-independent criteria.  Relevant morphological variables for classification are determined via decision tree (DT) analysis. Using Illex argentinus and Enteroctopus megalocyathus as case studies, individuals were sexed and assigned to a maturity stage defined by specific macroscopic maturity scales. Also, for each individual, the weight of the gonad, accessory glands\/ducts, mantle length, and total weight were recorded and maturity indices were calculated (Hayashi index and gonadosomatic index). Two different DT models were fitted: one considering all maturity stages and the other considering  only intermediate maturity stages since these are the most difficult to determine in practice. For the classification of I. argentinus among all stages, theweights of the nidamental gland and oviductswere the most relevant variables for females (misclassification 23%), while spermatophoric complex and testis weights were the key variables for males (misclassification 23%). For classification of intermediate stages only, the nidamental gland and spermatophoric complex weights were the most relevant variables to classify females (misclassification 19%) and males (misclassification 21%), respectively. For E. megalocyathus, the oviducts and ovary weights of females and the terminal organ weight of males were the most relevant  variables for classification among all maturity stages (misclassification 16% and 18%, respectively). For intermediate maturity stages, the same variables were most important and misclassification improved to 13% for both sexes. Gonadosomatic and Hayashi´s indices were not relevant in either model. DTs based on measurements of cephalopod reproductive systems revealed a simple classification systemfor maturity stages using only a few variables that are easy to measure in the field and are independent of observer training. Moreover, the present approach could be easily applied to other cephalopod species using biological data that already exist.","palabras_clave":"CEPHALOPODS|DECISION TREE|FISHERIES ASSESSMENT|MATURITY SCALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17217,"idioma_id":4,"titulo":"Morphological plasticity in the Aristotle's lantern of Arbacia dufresnii (Phymosomatoida: Arbaciidae) in Patagonian coast","resumen":"The relative size of the Aristotle´s lantern of most sea urchins varies in relation to the food availability and it is often used to infer the availability of food of the environment that the sea urchins inhabit. The aim of the present study was to evaluate the Aristotle´s lantern morphology plasticity of Arbacia dufresnii in populations with different environmental characteristics, either mussel beds or disturbed areas by the invasive alga Undaria pinnatifida along the Patagonian Atlantic coast. The test diameter of the sea urchins along with the weight and high of the lanterns, the jaw lenght and rotula lenght were measured. Classic and geometric morphometric analyses were performed to test differences among populations. The length of the jaw was the best indicator to describe the relative changes in size of the Aristotle´s lantern. The largest length of the jaw was measured in individuals from disturbed areas dominated by the invasive algae U. pinnatifida. The rotula shape changed with the increase of the diameter of the sea urchins, it tends to be more elongated with larger sea urchins.","palabras_clave":"ECHINOIDEA|ARBACIA DUFRESNII|PATAGONIA .|JAW|GEOMETRIC MORPHOMETRICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17218,"idioma_id":4,"titulo":"A SIMPLE MODEL FOR CONTROL OF TUMOR CELLS","resumen":"The Kirschner-Panetta model describes the poblational competition between effector cells and tumor cells. We analize external changes in the parameters and mechanisms to obtain the decreasing of tumor cells. These variations were performed by three different ways: Oscillations, spikes with the natural frequency of the system, and spikes with Normal Distribution. It was observed that the amount of tumor cells decreases to zero if we change simultaneously the parameters properly.","palabras_clave":"TUMOR|IMMUNE SYSTEM|IMMUNOTHERAPY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17219,"idioma_id":4,"titulo":"LUBRICATION PREDICTIONS FOR TOTAL KNEE PROSTHESIS MADE OF HARD MATERIALS","resumen":"The lubricated contact zone in a total knee prosthesis is  modeled, where femoral and tibial components are supposed to be made of hard  materials (high stiffness and hardness) and lubricated by a non Newtonian fluid  (synovial liquid). To determine optimal relations among geometric parameters,  load and film thickness, a generalized Reynolds equation was solved by means of  finite element method. Although mix lubrication regime is predominant, it is  shown that increasing conformity, it could be assure a full-film lubrication  regime in most of the gait cycle. These results might be a reference to make  more durable total knee prostheses. ","palabras_clave":"knee prosthesis. |lubrication|film thickness|finite element method"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17220,"idioma_id":5,"titulo":"características de personalidad en adolescentes con sobrepeso y obesidad","resumen":"Es sabido que ciertas características psicopatológicas tienen un peso relevante en la etiología y mantenimiento de la obesidad, destacando la dimensión multifactorial propia de la patología.  Si bien hay controversia respecto a un perfil de personalidad característico de los sujetos obesos, se ha encontrado que los adolescentes en esta condición suelen tener una autopercepción negativa de su imagen corporal, depresión y una  mayor prevalencia de baja autoestima.  El objetivo de este trabajo fue identificar los rasgos de personalidad de adolescentes escolarizados con sobrepeso y obesidad, residentes en ciudades del sur de la provincia de Tucumán (Argentina).  Se trató de un estudio comparativo, transversal, con muestreo no probabilístico o intencional.  Se hicieron mediciones antropométricas a 369 adolescentes escolarizados de11a18 años de edad, a quienes se aplicó un cuestionario de personalidad y una encuesta sociodemográfica.  Se encontró que una tercera parte de los adolescentes tenía sobrepeso y obesidad. El análisis de varianza mostró la existencia de diferencias estadísticas significativas en la escala de psicoticismo, lo que indica mayor agresividad, hostilidad e insensibilidad en las emociones de los adolescentes con normo-peso.  Los adolescentes con sobrepeso y obesidad se percibieron con mayor extraversión, lo que supone cierta compensación ante la presión social.  Los resultados no corroboraron un perfil de personalidad propio del sujeto obeso, por lo que resulta importante investigar variables mediado-res dela obesidad en población adolescente, particularmente laS vinculadas a la personalidad.","palabras_clave":"PERSONALIDAD|OBESIDAD|ADOLESCENCIA|PSICOTISMO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17221,"idioma_id":4,"titulo":"High-level expression and purification of recombinant wheat germ agglutinin in Rachiplusia nu larvae","resumen":"Wheat germ agglutinin (WGA) is a homodimeric lectin stabilized by non-covalent interactions. Each monomer of 171 residues, which has a complex structure with 16 disulfide bridges, determines two sites for the specific binding of N-acetyl-D-glucosamine and one for the specific binding of N-acetylneuraminic acid. Because of these folding requirements, the production of high yields of recombinant WGA is still not possible and its extraction from wheat germ is the only source for commercial purposes. This work reports for the first time the expression of WGA isolectin A (WGA A), using a baculovirus expression system in Sf9 cells and Rachiplusia nu larvae. High levels of recombinant WGA A were obtained in both cases, especially in R. nu, where yields reached 346.6 ± 88.5 &#956;g\/g of larvae. Also, an integrated purification method was developed based on aqueous two phase separation coupled to affinity chromatography using chitosan mini-spheres. The recombinant WGA A was able to recognize ovoalbumin sugar moieties, cross-react with anti-WGA serum and agglutinate human red blood cells, and showed the same behavior as that of commercial WGA in SDS-PAGE and RP-HPLC analyses.","palabras_clave":"WHEAT GERM AGGLUTININ|BACULOVIRUS|AQUEOUS TWO-FASE SYSTEM|CHITOSAN MINI-SPHERES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17222,"idioma_id":4,"titulo":"Plasma deposition of silver nanoparticles on ultrafiltration membranes: Antibacterial and anti-biofouling properties","resumen":"A novel and versatile plasma reactor was used to modify polyethersulphone commercial membranes. The equipmentwas applied to: (i) functionalize the membranes with low-temperature plasmas, (ii) deposit a film of poly(methylmethacrylate) (PMMA) by Plasma Enhanced Chemical Vapor Deposition (PECVD) and, (iii) deposit silver nanopar-ticles (SNP) by gas flow sputtering. Each modification process was performed in the same reactor consecutively,without exposure of the membranes to atmospheric air. Scanning electron microscopy and transmission electronmicroscopy were used to characterize the particles and modified membranes. SNP are evenly distributed on the mem-brane surface. Particle fixation and transport inside membranes were assessed before- and after-washing assays byX-ray photoelectron spectroscopy depth profiling analysis. PMMA addition improved SNP fixation. Plasma-treatedmembranes showed higher hydrophilicity. Anti-biofouling activity was successfully achieved against Gram-positive(Enterococcus faecalis) and -negative (Salmonella) Typhimurium bacteria. Therefore, disinfection by ultrafiltrationshowed substantial resistance to biofouling. The post-synthesis functionalization process developed provides a moreefficient fabrication route for anti-biofouling and anti-bacterial membranes used in the water treatment field. To thebest of our knowledge, this is the first report of a gas phase condensation process combined with a PECVD procedurein order to deposit SNP on commercial membranes to inhibit biofouling formation.","palabras_clave":"Ultrafiltration    |Plasma|Gas flow sputtering|XPS|Biofouling|Silver nanoparticles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17223,"idioma_id":5,"titulo":"La transición entre educación y trabajo de los adolescentes en la Argentina. Evaluación de impacto de la Asignación Universal por Hijo en la deserción escolar y la participación laboral","resumen":"Conforme a la evidencia empírica disponible, la incidencia de la deserción escolar generalmente es mayor entre los jóvenes que pertenecen a familias en situación de desventaja social y económica así como entre aquellos que participan del mercado laboral. En este contexto, el programa de transferencias denominado Asignación Universal por Hijo (AUH), implementado en la Argentina desde 2009, podría constituir una herramienta eficaz para reducir los niveles de abandono escolar entre los niños y jóvenes cubiertos. El objetivo central de este documento es examinar los efectos de este programa en los niveles de deserción escolar y participación laboral de los adolescentes. Con este fin, se utilizan los datos de la última Encuesta Nacional de Gasto de los Hogares (ENGHO) 2012\/13 que permite identificar a los titulares y beneficiarios directos del programa. Dada la información disponible, se implementa el método del Propensity Score Matching a fin de construir un grupo de comparación con características similares a los beneficiarios. Los resultados obtenidos sugieren que el programa AUH tiene un efecto negativo y significativo en las tasas de deserción de los adolescentes de 14 a 17 años que varía de 5 a 12 puntos porcentuales. Asimismo, las estimaciones indican que el programa también disminuyó la tasa de ocupación y las horas trabajadas entre los adolescentes cubiertos.","palabras_clave":"DESERCIÓN ESCOLAR|ADOLESCENTES|TRABAJO INFANTIL|PROTECCIÓN SOCIAL|ARGENTINA|ASIGNACIÓN UNIVERSAL POR HIJO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17224,"idioma_id":4,"titulo":"Three Members of the Bemisia tabaci (Hemiptera: Aleyrodidae) Cryptic Species Complex Occur Sympatrically in Argentine Horticultural Crops","resumen":"The whitefly, Bemisia tabaci (Gennadius), is a cryptic species complex that attacks >600different species of plants and transmits several plant viruses causing severe economic losses. Until 2010,the B. tabaci complex comprised 24 distinct putative species. Recently, at least 15 new species have beenreported. The objective of this study was to identify B. tabaci species present in bean, melon, and tomatocrops in Argentina by applying phylogenetic analyses and pairwise comparison of genetic distances of mitochondrialcytochrome c oxidase subunit I (mtCOI) sequences. The 39 proposed whitefly species wereidentified with both analyses, and the presence in Argentina of one indigenous species, New World 2(NW2), and two introduced species, Middle East-Asia Minor one (MEAM1) and Mediterranean, wasconfirmed. Common bean crop presented the three whitefly species detected, with NW2, MEAM1, andMediterranean being present all together under field conditions. Also, Mediterranean was the only speciesidentified in tomato, whereas MEAM1 was found in melon. To the best of our knowledge, Mediterraneanis a recent invasive species in open-field agriculture in the American continent and in greenhousetomato in Argentina. Additionally, we provide the first report of MEAM1 in common bean and melon.These findings raise several questions on the future scenario of B. tabaci and the viruses it transmits inArgentina.","palabras_clave":"WHITEFLY|PHYLOGENETIC ANALYSIS|MITOCHONDRIAL CYTOCHROME C OXIDASE SUBUNIT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17225,"idioma_id":4,"titulo":"Assessing the use of two southwestern Atlantic estuaries by different life cycle stages of the anadromous catfish Genidens barbus (Lacépède, 1803) as revealed by Sr:Ca and Ba:Ca ratios in otoliths","resumen":"            The objective of this study was to asses the long-term patterns of estuarine and estuarine-to-continental            shelf use by G. barbus in two estuaries in the southwestern Atlantic Ocean, using Sr:Ca and Ba:Ca ratios in            otoliths. The otoliths were rinsed with Milli-Q water and dried prior to the laser ablation ICP-MS analysis. G.            barbus showed high plasticity in its displacement patterns in the southwestern Atlantic Ocean. Present results            suggest the occurrence of different fish groups in that area, each one with a particular migratory behavior:            some specimens may undertake large migrations between the estuaries and the platform while others            may have higher degree of estuarine dependence. Such plasticity may be influenced by the environmental            conditions and food availability in the different areas frequented by the species.","palabras_clave":"Genidens barbus; | otolith| anadromous| migration"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17226,"idioma_id":4,"titulo":"New records of anadromous catfish Genidens barbus (Lacépède, 1803) in the Paraná Delta (South America): evidence of extent in migration corridor?","resumen":"        The catfish Genidens barbus (Siluriformes:Ariidae) is an anadromousspecies from South America. In        Argentina and Uruguay was classified as vulnerable due to its complex life cycle, restricted distribution in        fresh orestuarine waters and the critical status of this species fishery. In this work,we report the occurrence        of G. barbus in three great rivers that could represent the evidence of extent in its migration corridor in the        Paraná River Delta (Argentina).","palabras_clave":"Genidens barbus|Anadromous| Paraná River Delta;| Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17227,"idioma_id":4,"titulo":"First study of different insect cells to triatoma virus infection","resumen":"The use of viruses for biological control is a new option to be considered. The family Dicistroviridae, which affects only invertebrates, is one of the families that have been proposed for this purpose. The Triatoma virus (TrV), a member of this family, affects triatomine transmitters of Chagas disease, which is endemic in Latin America but also expanding its worldwide distribution. To this end, we attempted virus replication in Diptera, Aedes albopictus (clone C6\/36) and Lepidoptera Spodoptera frugiperda (SF9, SF21) and High Five (H5) cell lines. The methodologies used were transfection process, direct inoculation (purified virus), and inoculation of purified virus with trypsin. Results were confirmed by SDS-PAGE, Western blotting, RT-PCR, electron microscopy, and immunofluorescence. According to the results obtained, further analysis of susceptibility\/infection of H5 cells to TrV required to be studied.","palabras_clave":"DICISTROVIRUS|TRIATOMA VIRUS|CULTIVO CELULAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17228,"idioma_id":4,"titulo":"Detection of Triatomine infection by Triatoma virus and horizontal transmission: protecting insectaries and prospects for biological control","resumen":"Triatoma virus (TrV) is the only triatomine entomopathogenic virus identified so far. Propagation of TrV in insectaries depends on handling procedures and triatomine population dynamics. The effects of propagation can be devastating and entire colonies must often be sacrificed to prevent spread of the virusthroughout the insectary. This study found that after 41.3 days from TrV ingestion of human blood with 0.04 mg of viral protein by 5th instar Triatoma infestans, viral particles could be detected by RT-PCR; in a second horizontal transmission experiment time to detection resulted in a mean of 42.5 days. Theseresults should rise awareness of TrV dynamics in nature, help estimate the spread of this virus when TrV-infected field-collected insects are incorporated into an insectary, and provide a base for the consideration of TrV as an agent of biological control of some species of triatomines.","palabras_clave":"Triatoma virus |Triatoma infestans| Insectary"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17229,"idioma_id":5,"titulo":"Vitrificación: ¿una nueva alternativa de criopreservación espermática?","resumen":"La criopreservación de espermatozoides es un recurso importante para la conservación y el comercio de material genético (Maldjian y col., 2005), facilita la distribución de genes deseables, debido a la facilidad de su transporte y permite el control de la transmisión de ciertos patógenos (Johnson y col., 2000). Además, contribuye a la conservación de especies en peligro de extinción y ayuda a superar problemas de infertilidad (Watson 2000). Sin embargo, el método convencional de congelación espermática puede producir daño mecánico a la célula como consecuencia de la formación de cristales extra e intracelulares y\/o daño osmótico debido a la gran deshidratación. La vitrificación es un proceso mediante el cual el líquido pasa al estado vítreo o sólido sin la formación de cristales de hielo (Katkov y col., 2006). Más aun, es un procedimiento simple que requiere menor tiempo y tiene mayor costo-beneficio que la congelación convencional, ya que no necesita un equipo costoso ni un operador altamente capacitado para ejecutarla y tanto el proceso de vitrificación como el de atemperado se realizan en segundos (Sanchez y col., 2011). Hasta el momento se ha ensayado la vitrificación de espermatozoides porcinos en presencia y ausencia de crioprotectores permeables (4% de DMF o glicerol), utilizando como medio base sin crioprotector el medio Tyrode Albumin Lactate Pyruvate (TALP). Se han vitrificado espermatozoides con el método de cryoloop (Isachenko y col., 2004a) y con el método de esferas (Isachenko y col., 2008), a una concentración espermática de 20 y 5 x 106 esp.\/ml, respectivamente. Las muestras se conservaron en crioviales un mínimo de 24 h hasta su atemperado y evaluación. Los resultados obtenidos indican que los únicos parámetros seminales que no presentaron diferencias significativas en las muestras de semen porcino vitrificadas-atemperadas con respecto a las muestras previas a vitrificar, fueron la condensación e integridad de la cromatina espermática. La vitrificación en esferas, sin presencia de crioprotectores surge entonces como una nueva técnica de criopreservación espermática en porcinos, capaz de conservar células con una cromatina condensada e intacta. Al mantener la calidad del ADN, dichas células podrían conservar la capacidad de producir cigotos porcinos in vitro mediante la aplicación de la inyección intracitoplasmática de un espermatozoide (ICSI).","palabras_clave":"VITRIFICACION|SEMEN|PORCINO|CRIOPRESERVACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17230,"idioma_id":5,"titulo":"Efecto del protocolo de descongelación de semen sobre el porcentaje de preñez en bovinos lecheros","resumen":"Para analizar el efecto de protocolo de descongelado del semen sobre el porcentaje de preñez se trabajó en tres tambos del sur de la provincia de Santa Fe, Argentina. Se evaluó el tiempo empleado en retirar la pajuela del termo de nitrógeno hasta depositarla en el baño para descongelar, la temperatura del agua y el tiempo de inmersión de cada dosis para su descongelado y el tiempo empleado en cargar la dosis en la pistola y efectivizar la inseminación de cada hembra. El porcentaje de preñez se calculó a los 60 días postinseminación por ecografía transrectal y la calidad del semen utilizado se analizó mediante sistema CASA (SpermVision, Minitub, Alemania). El protocolo de descongelado no tuvo impacto sobre la preñez puesto que, en cada establecimiento, se cuidaron cada uno de sus pasos de manera exhaustiva hasta que la dosis seminal fue inseminada, sin embargo, el estado reproductivo varió significativamente en relación a la persona que realizó la inseminación y al momento del año en que se desarrolló la actividad. Es decir, que el impacto mayor sobre el porcentaje de preñez estuvo en relación a factores externos al manejo de las pajuelas y a la calidad del semen en sí mismo, sin duda faltan más estudios que permitan dilucidar con mayor profundidad este tema.","palabras_clave":"SEMEN|DESCONGELADO|BOVINOS|LECHEROS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17231,"idioma_id":4,"titulo":"Sorption, desorption and leaching potential of sulfonylurea herbicides in Argentinean soils","resumen":"The  sulfonylurea (SUs) herbicides are used to control broadleaf weeds and some  grasses in a variety of crops. They have become popular because of their low  application rates, low mammalian toxicity and an outstanding herbicidal  activity. Sorption is a major process influencing the fate of pesticides in  soil. The objective of this study was to characterize sorption-desorption of four  sulfonylurea herbicides: metsulfuron-methyl (methyl 2-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoylsulfamoyl)]benzoate),  sulfometuron-methyl (methyl 2-[(4,6-dimethylpyrimidin-2-yl)carbamoylsulfamoyl]benzoate),  rimsulfuron (1-(4,6-dimethoxypyrimidin-2-yl)-3-(3-ethylsulfonyl-2-pyridylsulfonyl)urea)  and nicosulfuron (2&#8209;[(4,6&#8209;dimethoxypyrimidin&#8209;2&#8209;yl)carbamoylsulfamoyl]&#8209;N,N&#8209;dimethylnicotinamide) from different soil horizons of different  landscape positions. Sorption was studied in the laboratory by batch  equilibration method. Sorption coefficients (Kd-SE) showed that rimsulfuron  (Kd-SE = 1.18 to 2.08 L Kg-1) and nicosulfuron (Kd-SE  = 0.02 to 0.47 L Kg-1) were more highly sorbed than metsulfuron-methyl  (Kd-SE = 0.00 to 0.05 L Kg-1) and sulfometuron-methyl (Kd-SE  = 0.00 to 0.05 L Kg-1). Sorption coefficients (Kd-SE) were  correlated with pH and organic carbon content. All four herbicides exhibited  desorption hysteresis where the desorption coefficients (Kd-D) &gt; Kd-SE.  To estimate the leaching potential, Koc and ground-water ubiquity  score (GUS) were used to calculate the half-life (t1\/2) required to  be classified as ?leacher? or ?nonleacher?. According to the results,  rimsulfuron and nicosulfuron herbicides would be classified as leachers, but factors  such as landscape position, soil depth and the rate of decomposition in surface  and subsurface soils ","palabras_clave":"Sorption|sulfonylurea herbicides|leaching potential|Argentinean soils|hysteresis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17232,"idioma_id":4,"titulo":"Performance of tuned mass damper against structural collapse due to near fault earthquakes","resumen":"The tuned mass dampers (TMD) are devices capable of reducing structural vibration bymeans of an energy transfer that is established between the structure to be protected and the control device. This vibration control strategy has a relatively recent use in civil structures, having been proven effective against the action of wind and far-fault earthquakes. Meanwhile, the near-fault seismic records have a short significant duration, with few pulses of high amplitude and low frequency. These characteristics raise a question about the TMD performance against this type of earthquakes, due to the device has a limited time to transfer energy from the main structure.In this paper the efficiency of the TMD to prevent the collapse of a structure subjected to the action of a series of near-fault records is analysed. The structure used is a 4-story steel frame on which a TMD with different values of mass is incorporated. From a series of nonlinear dynamic analysis, where the scale of seismic records is modified, the minimum amplitude of each record that produces the structural collapse is found. By comparison of the results of the structure with and without the addition of the control device, conclusions about its performance and capability in the prevention of collapse are established.","palabras_clave":"passive control|tuned mass damper|seismic loading|nonlinear structural analysis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17233,"idioma_id":4,"titulo":"Assessment of the physicochemical conditions sediments in a polluted tidal flat colonized by microbial mats in Bahía Blanca Estuary (Argentina)","resumen":"The aim of this work is to assess the physicochemical conditions of the supratidal sediments colonized by microbial mats at two sites from Rosales Harbor (Bahía Blanca Estuary, Argentina) close to sewage discharge. Both sites differed in the size grain. No differences in pH, Eh and temperature were observed. Moisture retention and chlorophyll a concentration were significantly different between sites and sediment layers. Heavy metals and organic matter content were significantly higher in SII. No statistical differences were found in porewater nutrients concentration, being higher in SI (except DSi). The presence of Escherichia coli in water and sediment (1000 CFU\/100 mL) uncountable and 35-40 CFU g-1 dw, respectively) evidenced microbial contamination in the study area. The relationships between the physicochemical parameters evaluated and the influence of the sewage Discharge allow defining two different areas in the Rosales Harbor despite the proximity and the presence of microbial mats.","palabras_clave":"Estuaries|microbial mats|environmental conditions|sediments"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17234,"idioma_id":5,"titulo":"Los mercados de trabajo agropecuarios en Argentina. Un proceso de diseño de estrategias metodológicas para captar un objeto complejo","resumen":"RELMIS es una iniciativa del Programa de Estudios sobre Acción Colectiva y Conflicto Social del CIECS (CONICET y UNC), del Centro de Investigaciones y Estudios Sociológicos (CIES) y del Nodo Villa María (Argentina) de la Red Latinoamericana de Metodología de las Ciencias Sociales. Se encuentra indizada\/ catalogada en: e-Revistas; Latindex Directorio; DOAJ; Dialnet; EBSCO; NewJour. Resumen del artículo: Los mercados de trabajo agropecuarios argentinos son un objeto complejo de investigación social, debido a sus particularidades respecto a otros mercados del agro latinoamericano y a los urbano-industriales y por sus heterogeneidades regionales. Las estadísticas públicas oficiales de Argentina presentan dificultades para captar esta complejidad y medir con rigurosidad las características de los empleos del sector y a los trabajadores que en él se desempeñan. Por este motivo, este artículo presenta el proceso de diseño de una estrategia metodológica desarrollada para la investigación de diversos mercados de trabajo agropecuarios. Esta estrategia metodológica articula abordajes cuantitativos y cualitativos, y es producto del análisis de las limitaciones de los datos estadísticos públicos existentes y del reconocimiento de relevantes problemáticas y características particulares de este objeto de estudio complejo. El análisis fundamentó el desarrollo de instrumentos de relevamiento específicos. El artículo también incluye sugerencias y advertencias que caben ser consideradas cuando se investiga sobre este objeto de estudio.","palabras_clave":"mercados de trabajo agropecuarios |diseño de estrategia metodológica |estadísticas oficiales|regiones de Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17235,"idioma_id":4,"titulo":"Records of medicinal plants utilized as gastroprotective and for treatment of gastrointestinal ulcers, gastritis and heartburn in Argentina: a survey of literature","resumen":"Traditional knowledge available on 148 plant species used in Argentina for gastroprotection and treating gastrointestinal ulcers, gastritis, and heartburn, was compiled to analyze their taxonomic grouping, floristic richness, the life form, and organs used, and to determine their susceptibility to over-collection.","palabras_clave":"--"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17236,"idioma_id":4,"titulo":"Bioremediation of crude oil-contaminated soil by immobilized bacteria on an agro-industrial waste -sunflower seed husks","resumen":"This study reports the  immobilization and performance of a hydrocarbon degrading Rhodococcus sp.  strain (designated as QBTo) on sunflower seed husks (SH) for the bioremediation  of soils polluted with crude oil. The SH performance as inoculants carrier was  compared with peat, which is a vegetal material traditionally used in  carrier-based inoculants production. The stability of the immobilized culture  under storage conditions was assessed by viability at different times when  stored at 25ºC and 10ºC. The catabolic activity of immobilized and free QTBo  cells introduced into sandy loam soil, freshly contaminated with crude oil, was  studied in microcosms. A higher number of viable QTBo cells were recovered from  the inoculants formulated with SH (SHQTBo) after prolonged storage at 10 °C and  25 ºC. The microcosms amended with SH-QTBo inoculants showed a removal of about  66% of total petroleum&nbsp;&nbsp; hydrocarbons  (TPH), meanwhile in those inoculated with QTBo-peat inoculants,the decrease was  of about 47%. In the control microcosms (non-inoculated) and liquid  culture-amended soils the THP removal was about 28%. SH is a waste of edible  oil industry, non toxic and biodegradable which has demonstrated to confer to  the immobilized cultures greater potential to survive not only during storage  but also in the soil environment improving bioremediation process.          ","palabras_clave":"hydrocarbon-degrading bacteria |immovilization|inoculant|bioremediation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17237,"idioma_id":4,"titulo":"Using multi-temporal Landsat imagery and linear mixed models for assessing water quality parameters in Río Tercero reservoir (Argentina)","resumen":"The application of remote sensing technology to water quality monitoring has special significance for lake management at regional scales. Many studies have proposed algorithms between Landsat data and in-situ water quality parameters using classical regression models. The novelty of this paper is that we developed algorithms to determine log-transformed chlorophyll-a concentration (Chl-a) and Secchi disk transparency (SDT) in Río Tercero reservoir using Landsat TM and ETM+ imagery, ancillary environmental factors and linear mixed models (LMM), obtaining an increase in the accuracy of the estimates. The validation results showed that LMM with spatial correlation structure that take into account water surface temperature (WST) and rainfall were the most suitable method for estimating these parameters. WST derived from the Landsat thermal band was also validated. The algorithms were used to generate quantitative maps providing spatially and temporally rich information on patterns of water quality throughout the reservoir. Water quality features related to the hydrogeomorphology of the reservoir, typical seasonality and influx from the cooling system of a local nuclear reactor were identified in the time series maps.","palabras_clave":"REMOTE SENSING|RESERVOIR|LANDSAT|WATER QUALITY|LINEAR MIXED MODELS|ALGORITHMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17238,"idioma_id":4,"titulo":"Modelling extraordinary floods and sedimentological processes in a large channel-floodplain system of the Lower Paraná River (Argentina)","resumen":"A quasi-2D unsteady flow and sediment transport model suitable for the simulation of large lowland river systems, including their floodplains, is presented. The water flow and sediment equations are discretised using an interconnected irregular cells scheme, in which different simplifications of the 1D de Saint Venant equations are used to define the discharge laws between cells. Spatially-distributed transport and deposition of fine sediments throughout the river-floodplain system are simulated. The model is applied over a 208-km reach of the Paraná River between the cities of Diamante and Ramallo (Argentina) comprising a river-floodplain area of 8100 km². After calibration and validation, the model is applied to predict water and sediment dynamics during synthetically generated extraordinary floods of 100, 1000, and 10,000 years return period. The potential impact of a 56-km long road embankment constructed across the entire floodplain is simulated and compared to model results without the embankment. The embankment results in increases in upstream water levels, inundation extent, flow duration, and sediment deposition.","palabras_clave":"Numerical modelling|Floodplain sedimentation|Lowland river|Paraná River"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17239,"idioma_id":5,"titulo":"DIETA Y COMPORTAMIENTO DE ALIMENTACIÓN DEL OSTRERO AUSTRAL (HAEMATOPUS LEUCOPODUS) DURANTE EL PERÍODO POS-REPRODUCTIVO EN EL ESTUARIO DEL RÍO GALLEGOS, PATAGONIA, ARGENTINA","resumen":"La dieta de varias especies de ostreros ha sido estudiada en detalle, sin embargo,  hay poca información sobre el Ostrero Austral (Haematopus leucopodus), una especie endémica de la Patagonia. Se estudió la dieta y comportamiento de alimentación de la especie durante el período pos-reproductivo en el estuario del río Gallegos, una de sus principales áreas de invernada. Se efectuaron observaciones sobre el comportamiento de alimentación y se midieron los restos de presas para determinar la distribución de tallas de las presas ingeridas. Asimismo se cuantificó  la disponibilidad y distribución de tallas de bivalvos en el sustrato, con el objeto de compararlas con las tallas ingeridas. La almeja Darina solenoides fue la presa más consumida (77%), seguida por el mejillón Mytilus edulis platensis (16%) y poliquetos (menos del 6%). Ambos moluscos estuvieron disponibles en importantes cantidades en el intermareal aunque los ostreros prefirieron las almejas, probablemente porque los mejillones requieren mayor tiempo de manipulación. La técnica de alimentación empleada al consumir mejillones se correspondió con el tipo descripto como ?martilladores ventrales?, mientras que almejas o poliquetos eran consumidos con la técnica de ?probadores?. El Ostrero Austral mostró una alta selectividad alimentándose de tallas medianas, una tendencia también señalada para otras especies.","palabras_clave":"ecología trófica|aves playeras|selección de presas|Ostrero Magallánico"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17240,"idioma_id":4,"titulo":"Morphology and cyclic activity of the digestive gland of Zidona dufresnei (Caenogastropoda: Volutidae)","resumen":"                  Zidona dufresnei is a carnivorous snail that  plays an important role in the trophic web as a top predator. It is a threatened  species due to high levels of fisheries exploitation. In this study, we describe  the morphology of the digestive gland of Z.  dufresnei from Mar del Plata, Argentina,  and discuss the function and the cycle of activity of the different cell types.  Histological analysis reveals two types of tubules: type 1 tubules composed of  digestive and basophilic cells and type 2 tubules lined by basophilic cells  only. Pyramidal basophilic cells contain lipofuscin and a large amount of rough  endoplasmic reticulum, which suggests that these cells are responsible for the  secretion of digestive enzymes that initiate the extracellular digestion of the  food. Columnar digestive cells exhibit large membrane-bound vesicles that  contain proteoglycans, neutral glycosaminoglycans and small amounts of lipid  and lipofuscin. The presence in digestive cells of many endocytic vesicles and residual  lysosomal bodies, as evidenced by the presence of lipofuscin pigments in the  apical region, indicate that digestion is completed intracellularly within  these cells. The digestive cells are subject to cyclical changes involving four phases:  initial, digestion, fragmentation, and disintegration stages.  ","palabras_clave":"gastropods|Digestive gland|Volutidae"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17241,"idioma_id":5,"titulo":"La enseñanza de la impersonalidad en la escritura de géneros académicos","resumen":"Desde el interaccionismo socio-discursivo, analizamos la enseñanza de la impersonalidad en una clase de escritura académica en el nivel universitario con el objeto de conocer cómo se enseñan nociones gramaticales (tercera persona, voz pasiva e impersonalidad) en función de la escritura de textos académicos. Para ello exponemos en primer lugar cómo se articulan dos órdenes, el gramatical y el discursivo-textual en las explicaciones de la docente; en segundo lugar, nos detenemos en el análisis de los razonamientos gramaticales en las interacciones entre la docente y los alumnos. Finalmente, sistematizamos un conjunto de consideraciones en función de la preparación de secuencias didácticas, puesto que desde la didáctica de la lengua, consideramos que el análisis y la investigación deben sustentar las prácticas y sus transformaciones.","palabras_clave":"DIDÁCTICA DE LA LENGUA|ESCRITURA|RAZONAMIENTOS GRAMATICALES|IMPERSONALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17242,"idioma_id":4,"titulo":"Branching angles reflect a trade-off between reducing trail maintenance costs or travel distances in leaf-cutting ants","resumen":"The design of transport paths in consuming entities that use routes to access food should be under strong selective pressures to reduce costs and increase benefits. We studied the adaptive nature of branching angles in foraging trail networks of the two most abundant tropical leaf-cutting ant species. We mathematically assessed how these angles should reflect the relative weight of the pressure for reducing either trail maintenance effort or traveling distances. Bifurcation angles of ant foraging trails strongly differ depending on the location of the nests. Ant colonies in open areas showed more acute branching angles that best shorten travel distances but create longer new trail sections to maintain than a perpendicular branch, suggesting that trail maintenance costs are smaller compared to the benefit of reduced traveling distance. Conversely, ant colonies in forest showed less acute branching angles indicating that maintenance costs are of larger importance relative to the benefits of shortening travel distances. The trail pattern evident in forests may be attributable to huge amounts of litter fall that increases trail maintenance costs, and the abundant canopy cover that reduces traveling costs by mitigating direct sunlight and rain. These results suggest that branching angles represent a tradeoff between reducing maintenance work and shortening travel distances, illustrating how animal constructions can adjust to diverse environmental conditions. This idea may help understand diverse networks systems, including urban travel networks.","palabras_clave":"ANT BEHAVIOR|ANT FORAGING|ATTA CEPHALOTES|ATTA COLOMBICA|DENDRITIC SYSTEMS|EXTENDED PHENOTYPE|FORAGING TRAILS|TROPICAL FORESTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17243,"idioma_id":4,"titulo":"Pericarp anatomy and hormone profiles of cypselas in dormant and non-dormant inbred sunflower lines","resumen":"ABSTRACT  The pericarp anatomy and the effects of storage after harvest, storage temperature and  early cypsela imbibition on phytohormone profiles were studied in inbred sunflower  lines B123 and B91. On day 0, germination of B123 cypselas was near 0%, indicating  dormancy, whereas that of B91 cypselas was near 100%, indicating non-dormancy.  The germination of B123 and B91 on day 33 at room temperature (25 °C) storage was  similar. Cell wall thickness and sclerification of the pericarp were higher in B123 than  B91, suggesting that structural characteristics may contribute to physical dormancy in  B123. Jasmonates (JAs), salicylic acid (SA) and abscisic acid (ABA) were measured in  dry and imbibed pericarps. SA content of dry pericarp was higher on day 33 than day  0. SA content during imbibition on day 33 was similar for room and low (20 °C)  storage temperatures. ABA content after 12 h imbibition was similar on days 0 and 33  at low temperature, but it increased on day 33 at room temperature for B123. 12-Oxophytodienoic  acid (OPDA) was maximal on day 0 for B123, but peaked at day 33 at  low temperature for B91. JA was higher on days 0 and 33 at room temperature as compared  with low temperature. Our findings indicate that pericarp hormone profiles are  affected in the two lines with different dormancy degree depending on storage conditions  and imbibition processes","palabras_clave":"PERICARP ANATOMY|DORMANT INBRED LINES|SUNFLOWER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17244,"idioma_id":4,"titulo":"Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal","resumen":"The nicotine (NIC) withdrawal syndrome is considered to be a major cause of the high relapse rate among individuals undergoing smoking cessation. The aim of the present study was to evaluate a possible role of GABAB receptors in NIC withdrawal, by comparing GABAB1 knockout mice and their wild-type littermates. We analysed the time course of the global withdrawal score, the anxiety-like effects, monoamine concentrations, the brain-derived neurotrophic factor (BDNF) expression, the corticosterone plasmatic levels and [3H]epibatidine binding sites during NIC withdrawal precipitated by mecamylamine, a nicotinic receptor antagonist (MEC). In NIC withdrawn wild-type mice, we observed a global withdrawal score, an anxiety-like effect in the elevated plus maze, a decrease of the striatal dopamine and 3,4-dihydroxyphenylacetic acid concentrations, an increase of corticosterone plasma levels, a reduction of BDNF expression in several brain areas and an increase of [3H]epibatidine binding sites in specific brain regions. Interestingly, the effects found in NIC withdrawn wild-type mice were absent in GABAB1 knockout mice, suggesting that GABAB1 subunit of the GABAB receptor is involved in the regulation of the behavioural and biochemical alterations induced by NIC withdrawal in mice. These results reveal an interaction between the GABAB receptors and the neurochemical systems through which NIC exerts its long-term effects.","palabras_clave":"NICOTINE|GABAB|RECEPTOR|WITHDRAWAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17245,"idioma_id":4,"titulo":"Formation of Ag nanowires on graphite stepped surfaces. A DFT study","resumen":"We investigate the feasibility of obtaining silver nanowires on graphite stepped surfaces theoretically, using Density Functional Theory calculations. Three layers slabs are used to model graphite surfaces with and without defects. Adsorption energies for Ag atoms on graphite surfaces were calculated showing the preference of Ag adatoms to locate on the steps, forming linear structures like nanowires. An analysis of the charge densities and projected densities of states for the different structures is also performed.","palabras_clave":"Ag|HOPG|DFT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17246,"idioma_id":4,"titulo":"Exogenous GM1 ganglioside increases accumbal BDNF levels in rats","resumen":"Gangliosides are compounds that are abundant throughout the CNS, participating actively in neuroplasticity. We previously described that exogenous GM1 ganglioside pretreatment enhances the rewarding properties of cocaine, evidenced by a lower number of sessions and\/or dosage necessary to induce conditioned place preference (CPP). Since GM1 pretreatment did not modify cocaine´s pharmacokinetic parameters, we suspected that the increased rewarding effect found might be mediated by BDNF, a neurotrophic factor closely related to cocaine addiction. This study was performed to investigate the possibility that GM1 may induce changes in BDNF levels in the nucleus accumbens (NAc), a core structure in the brain´s reward circuitry, of rats submitted to three conditioning sessions with cocaine (10 mg\/kg, i.p.). The results demonstrate that GM1 administration, which showed no rewarding effect by itself in the CPP, induced a significant increase of BDNF protein levels in the NAc, which may account for the increased rewarding effect of cocaine shown in the CPP paradigm.","palabras_clave":"GM1|BDNF|COCAINE|REWARD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17247,"idioma_id":4,"titulo":"Multiplicative Lidskii's inequalities and optimal perturbations of frames","resumen":"In this paper we study two design problems in frame theory: on the one hand, given a fixed finite frame F={f_j}j=1^n for C^d we compute those dual framesG of F that are optimal perturbations of the canonical dual frame forF under certain restrictions on the norms of the elements of G. On the other hand, we compute those VF={Vf_j}j=1^n - for invertible operators V which are close to the identity - that are optimal perturbations of F. That is, we compute the optimal perturbations of F among frames G={g_j}j=1^n that have the same linear relations as F. In both cases, optimality is measured with respect to submajorization of the eigenvalues of the frame operators. Hence, our optimal designs are minimizers of a family of convex potentials that include the frame potential and the mean squared error. The key tool for these results is amultiplicative analogue of Lidskii's inequality in terms of log-majorization and a characterization of the case of equality.","palabras_clave":"perturbation of frames|majorization|Lidskii's inequality|convex potentials"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17248,"idioma_id":4,"titulo":"Secretory structures in Flourensia campestris and F. oolepis: distribution, ultrastructure and functional roles.","resumen":"Peltate glandular trichomes were present in all organs of Flourensia campestris (FC) and F.  23 oolepis (FO) except roots. Our results are the first to report these structures in reproductive  24 organs, being abundant in involucral bracts and corolla of tubulose and ligulate flowers, and  25 found typically associated to edges and veins. They were the main secretory structures found  26 in capitula, leaves and stems (primary growth ?PG? and secondary growth with incipient  27 phellogen activity ?SGph?), while schizogenous ducts were most important in woody stems  28 and roots.  29 Ultrastructural studies revealed the presence of plastids, mitochondria, dyctiosomes and  30 endoplasmic reticulum in trichomes and ducts. The Flourensia species studied differed in the  31 way in which secretory products from glandular trichomes accumulate and are released to the  32 outside: through cracks or pores in FC, or through a loose cuticle in FO. In the ducts,  33 secretions are produced by both subepithelial and epithelial cells, in which they accumulate in  34 lipophilic vacuoles before being transferred to the duct. The presence of wall ingrowths in  35 subepithelial cells suggests that granulocrine secretion operates in these species.  36 The functional role of secretory structures in the production and secretion of (-)-Hamanasic  37 acid A ((-)HAA) was evaluated in both species. (-)HAA was only detected in surface secreted  38 resins and its concentration was intimately associated with the distribution and density of  39 glandular trichomes in each organ (capitula, leaves and stems ?PG and SGph?). In addition, no  40 (-)HAA was detected internally in the resins collected from secretory ducts. The composition  41 of these resins showed distinctive profiles for FC and FO, and only four from ca. 30  42 compounds detected were shared by both species. Summed to the elucidation of ultrastructural","palabras_clave":"FLOURENSIA OOLEPIS|FLOURENSIA CAMPESTRIS|SECRETORY SCTRUCTURES|ULTRSTRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17249,"idioma_id":5,"titulo":"Impacto de las características de ciertos grafemas en la formación de representaciones ortográficas del español","resumen":"Share (1999; 2004; 2008; 2011) ha propuesto que la recodificación fonológica actúa como un mecanismo que permite almacenar la forma ortográfica de las palabras. Sin embargo, existen estudios que han sugerido que existirían ciertas características de las correspondencias entre grafemas y fonemas que podrían obstaculizar este proceso. El objetivo del presente trabajo fue explorar si aquellos grafemas que pueden corresponder a dos o más sonidos (es decir, que tienen dos posibles traducciones fonológicas, por ej., &lt;G&gt; como \/j\/ o como \/gu\/) o que tienen muy baja frecuencia de aparición respecto de su par homófono (por ej., &lt;Z&gt; posee un porcentaje de frecuencia diez veces menor a &lt;S&gt;) dificultan la formación de representaciones ortográficas de las palabras en español. Para ello, 54 sujetos que cursaban el 3er grado de escolaridad primaria recodificaron fonológicamente pseudopalabras con y sin este tipo de grafemas. Luego de las sesiones de entrenamiento, se evaluaba, mediante una prueba de decisión léxica y una prueba de escritura de las pseudopalabras, si efectivamente los sujetos habían podido almacenar la forma ortográfica de las pseudopalabras leídas. Los resultados obtenidos mostraron que los sujetos tendieron a cometer significativamente más errores en el post-test en las pseudopalabras con grafemas ambiguos y de baja frecuencia respecto de su par homófono que en las pseudopalabras que no incluían este tipo de dificultad. Estos resultados sugieren que la ambigüedad fonológica y la baja frecuencia respecto de su par homófono de algunos grafemas impactan negativamente en el proceso de formación de representaciones ortográficas de las palabras en español. El objetivo del presente trabajo fue explorar si aquellos grafemas que pueden corresponder a dos o más sonidos (es decir, que tienen dos posibles traducciones fonológicas, por ej., &lt;G&gt; como \/j\/ o como \/gu\/) o que tienen muy baja frecuencia de aparición respecto de su par homófono (por ej., &lt;Z&gt; posee un porcentaje de frecuencia diez veces menor a &lt;S&gt;) dificultan la formación de representaciones ortográficas de las palabras en español. Para ello, 54 sujetos que cursaban el 3er grado de escolaridad primaria recodificaron fonológicamente pseudopalabras con y sin este tipo de grafemas. Luego de las sesiones de entrenamiento, se evaluaba, mediante una prueba de decisión léxica y una prueba de escritura de las pseudopalabras, si efectivamente los sujetos habían podido almacenar la forma ortográfica de las pseudopalabras leídas. Los resultados obtenidos mostraron que los sujetos tendieron a cometer significativamente más errores en el post-test en las pseudopalabras con grafemas ambiguos y de baja frecuencia respecto de su par homófono que en las pseudopalabras que no incluían este tipo de dificultad. Estos resultados sugieren que la ambigüedad fonológica y la baja frecuencia respecto de su par homófono de algunos grafemas impactan negativamente en el proceso de formación de representaciones ortográficas de las palabras en español. ","palabras_clave":"REPRESENTACIONES ORTOGRÁFICAS|NIÑOS|FRECUENCIA RELATIVA DE LOS GRAFEMAS|GRAFEMAS CON AMBIGÜEDAD FONOLÓGICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17250,"idioma_id":4,"titulo":"Crop rotation and seasonal effects on fatty acid profiles of neutral and phospholipids extracted from no-till agricultural soils","resumen":"Analysis of phospholipids (PLFA) and neutral lipids fatty acids (NLFA) was used to characterizeno-till productive agricultural soils associated with different crop rotation levels, replicated across a400 km transect in the Argentinean pampas, during two sampling seasons, summer and winter. Highrotation (HR) management consisted in maize?wheat?soybean intense rotation including cover crops.Low rotation (LR) management trend to soybean monocultures. Soils from nearby naturalenvironments (NEs) were used as references. Fatty acids concentration in soils (nmol\/g) decreased c.a.50% from summer to winter differentially according to soil treatment being the smallest decrease inHR management 35%. Both PLFA and NLFA profiles showed strong potential to discriminatebetween different land uses. In winter samples, some rare or unknown fatty acids were relevant forthe discrimination of agricultural practices while NLFA 20:0 appears to be a good marker of HRsoils despite season or location. The PLFA-based taxonomic biomarkers for total bacteria, Gramnegativebacteria and arbuscular mycorrhiza showed a significant trend NE&gt;HR&gt;LR in the wintersampling. HR management was also characterized by high levels of NLFA in winter samples as ifhigh crop rotation improves lipids reserves in soil during winter more than in monocropping soilmanagement. In conclusion, PLFA and particularly NLFA profiles appear to provide useful andcomplementary information to obtain a footprint of different soil use and managements, improvingsoil biochemistry characterization tools","palabras_clave":"Agriculture|soil lipids|no-tillage|crop rotation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17251,"idioma_id":4,"titulo":"Chloroplast dimorphism in leaves of Cabomba caroliniana (Cabombaceae)","resumen":"Cabomba Aublet is useful a 24 s a genetic model of angiosperm evolution. Previous 25 anatomical studies and preliminary light microscopic observations on C. caroliniana A 26 Gray revealed the presence of dimorphic chloroplasts in both types of leaves, floating 27 and submerged leaves. Leaf anatomy and chloroplasts ultrastructure were analyzed and 28 compared. The chloroplast ultrastructure of the mesophyll and epidermal cells is 29 different. Mesophyll chloroplasts have several plastoglobuli, large starch grains and 30 grana formed by an average of 29 thylakoids. Epidermal chloroplasts are smaller, have 31 grana formed by an average of 9 thylakoids and starch grains are occasional and 32 smaller. A statistical analysis (t-test) was made to determine if differences between  33 chloroplasts are significant. The ultrastructure of the epidermis chloroplast is similar to 34 the one of sun leaves chloroplasts and the ultrastructure of the mesophyll chloroplast is 35 similar to the one of shade chloroplast observed in other species.","palabras_clave":"Cabomba|Leaf anatomy|Chloroplast ultrastructure|ANA grade"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17252,"idioma_id":4,"titulo":"Biochemical changes in certain enzymes of Lysapsus limellium (Anura: Hylidae) exposed to chlorpyrifos","resumen":"Abstract:enzyme biomarkers (AChE: acetylcholinesterase, CbE: carboxylesterase, GST: glutathione-S-transferase, CAT: catalase) were measured in digestive tissues of Lysapsus limellum frogs collected from a rice field (RF: chlorpyriphos sprayed by aircraft) and a non-contaminated area (RS: reference site), immediately (24 h) and 168 h after aerial spraying with chlorpyrifos (CPF). CPF degradation was also searched in water samples collected from RF and RS, and found that insecticide concentration was reduced to&#8776;6.78% of the original concentration in RF at 168 h. A significant reduction of AChE and CbE activities was detected in L. limellum from RF in stomach and liver at 24 and 168 h, and in intestine only at 24 h, with respect to RS individuals. CAT activity decreased in intestine of L. limellum from RF 24 h and 168 h after exposure to CPF, whereas GST decreased in that tissue only at 24 h. In stomach and liver, a decrease was observed only at 168 h in both CAT and GST. The use of biomarkers (AChE, CbE, GST, and CAT) provides different lines of evidences for ecotoxicological risk assessment of wild frog populations at sites contaminated with pesticides.","palabras_clave":"Lysapsus limellium|Chlorpyrifos|Rice field"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17253,"idioma_id":4,"titulo":"Range additivity, shorted operator and the Sherman-Morrison-Woodbury formula","resumen":"We say that two operators A, B have the range additivityproperty if R(A + B) = R(A) + R(B). In this article westudy the relationship between range additivity, shortedoperator and certain Hilbert space decomposition knownas compatibility. As an application, we extend to infinitedimensional Hilbert space operators a formula of Fill andFishkind related to the well-known Sherman?Morrison?Woodbury formula.","palabras_clave":"ADITIVIDAD DE RANGOS|COMPATIBILIDAD|PSEUDOINVERSAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17254,"idioma_id":4,"titulo":"On the geometry of normal projections in Krein spaces","resumen":"Let $\\h$ be a Krein space with fundamental symmetry $J$. Along this paper, the geometric structure of the set of $J$-normal projections $\\q$ is studied. The group of $J$-unitary operators $\\uj$ naturally acts on $\\q$. Each orbit of this action turns out to be an analytic homogeneous space of $\\uj$, and a connected component of $\\q$. The relationship between $\\q$ and the set $\\e$ of $J$-selfadjoint projections is analized: both sets are analytic submanifolds of $L(\\h)$ and there is a natural real analytic submersion from $\\q$ onto $\\e$, namely $Q\\mapsto QQ^\\#$.The range of a $J$-normal projection is always a pseudo-regular subspace. Then, for a fixed pseudo-regular subspace $\\s$, it is proved that the set of $J$-normal projections onto $\\s$ is a covering space of the subset of $J$-normal projections onto $\\s$ with fixed regular part.","palabras_clave":"normal operator|projection|Krein space|submanifold"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17255,"idioma_id":5,"titulo":"Estudio de la cinética de captación de ácido siálico por larvas musculares de Trichinella spiralis","resumen":"Se ha comunicado que los eritrocitos (GR) incubados con larvas infectantes de T.spiralis presentan mayor agregación que los GR Controles incubados con solución salina, indicando que el parásito capta el ácido siálico globular. El objetivo fue estudiar la cinética de captación de ácido siálico por larvas musculares de T.spiralis aplicando Análisis Digital de Imágenes. Se trabajó con concentrados larvales de T.spiralis incubados en partes iguales con GR Grupo O, en medio salino y enzimático (GR Tratados), durante 120 minutos a intervalos de 15 minutos. Los Controles fueron incubados con igual volumen de solución salina. Se aplicó Análisis Digital de Imágenes y se calculó el valor del Coeficiente de células aisladas (CCA). Para analizar el efecto del tiempo de incubación en los valores de CCA, se utilizó un análisis de la variancia para un diseño en bloques completos aleatorizados. Los resultados mostraron que el valor promedio de CCA, en ambos medios, varió significativamente con el tiempo de incubación, evidenciando que el aumento del contacto de las larvas con los GR produce una disminución del ácido siálico que se refleja en mayores valores de CCA. La experiencia realizada sugeriría que durante su permanencia y viabilidad en el quiste, las larvas de T.spiralis podrían ir captando ácido siálico de la célula muscular con el objeto de interferir y\/o evadir la respuesta inmune del hospedador.","palabras_clave":"T.SPIRALIS|CINÉTICA| ÁCIDO SIÁLICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17256,"idioma_id":5,"titulo":"Educación Superior: desafíos de la virtualidad","resumen":"Las autoras de este trabajo son integrantes del proyecto denominado ?Oportunidades y desafíos de las Tecnologías de la Información y la Comunicación y los Entornos Virtuales para educar y educarse?, que investiga sobre educación mediada por tecnologías y realiza propuestas pedagógicas -híbridas y virtuales- con tecnologías desde el año 2000.   Internet y las Tecnologías de la Información y la Comunicación (TIC) se han instalado en las aulas en todos los niveles educativos. Se generó mucha expectativa en cuanto a las transformaciones que esto implicaría; sin embargo, no se produjeron los cambios esperados, ya que no es la tecnología per se la que origina la innovación, sino su uso y aplicación.  El propósito de este artículo es reflexionar sobre las nuevas metodologías de enseñanza: la educación mediada por tecnologías, el uso de entornos virtuales de aprendizaje y los MOOCs y los desafíos que éstas plantean para las instituciones universitarias y para todos los actores involucrados. Además, se analizan las ventajas y desventajas de estas metodologías educativas y las implicancias de su utilización.   Se presentan estrategias para potenciar la combinación de educación y TIC y garantizar la calidad de las propuestas pedagógicas.","palabras_clave":"Educación superior |Capacitación |Financiamiento |Legislación"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17257,"idioma_id":4,"titulo":"Robust nonlinear principal components","resumen":"All known approaches to nonlinear principal components are based on minimizing a quadratic loss, which makes them sensitive to data contamination. A predictive  approach in which a spline curve is fit minimizing a residual M-scale is proposed for this problem. For a p-dimensional random sample $x_i (i = 1, . . . , n)$ the method finds a function $h : R\\rightarrow R^p$ and a set ${t1, . . . , tn}\\subset R$ that minimize a joint M-scale of the residuals $x_i-h(t_i )$, where $h$ ranges on the family of splines with a given number of knots. The computation of the curve then becomes the iterative computing of regression S-estimators. The starting values are obtained from a robust linear principal components estimator. A simulation study and the analysis of a real data set indicate that the proposed approach is almost as good as other proposals for row-wise contamination, and is better for element-wise contamination.","palabras_clave":"S-ESTIMATORS|SPLINES|PRINCIPAL CURVES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17258,"idioma_id":4,"titulo":"Alternatives for handling rice (Oryza sativa L.) straw to favor its decomposition in direct sowing systems and their incidence on soil compaction","resumen":"Over 85% of the worldwide area planted with rice is irrigated, mainly by flooding, because this method increases yields. Irrigation by flooding provides this crop with particular characteristics, including at harvest, when it causes difficulties for machinery traffic due to the high soil water content. In addition to this, a large amount of green material is left on the soil, which if not burned, a practice which is prohibited or in the process thereof in many countries, impedes later work to the point where over 600 to 800 kg\/ha affects establishment of rice in the following season. The above is complicated by the use of direct sowing (DS), which achieves positive results, both in lowering costs and recovering soil, although there is no knowledge of how the planosol soils in Corrientes Province, Argentina, behave under these traffic conditions. The main objectives of this study were to: a) Find out how tools can be used best for improving decomposition of residue from harvesting rice grown under DS and their impact on soil compaction, and b) determine, for short periods, the amount of rice straws deposited on the surface and its decomposition time with various management techniques. A split plot with main factor arranged in a randomized complete block design with four replicates was performed. The use of harvester without spreader, harvester with rubber-flailed spreader, and harvester with metal-flailed spreader was assessed as the main factor. Additionally, three decomposition methods of rice straw were studied as split factor: passing a roller crimper over rice straw, control weed of rice straw with stubble chopper, and burning rice straw. The main results were: a) The harvester without spreader deposited more material in the center of the tail (21.680 kg\/ha) decreasing toward the sides, and b) distribution done by the harvester with metal-flailed spreader was somewhat similar to the harvester with rubber-flailed spreader but with slightly less uniform deposits. The main conclusions were: 1) When planosol soil was trafficked with loads of 152.5 kN, the cone index increased in the subsoil, affecting next growing season, 2) management alternatives that left residue cover attenuated soil compaction caused by the harvester traffic, and 3) the use of a stubble chopper or roller crimper on the rice straw distributed by the harvesters with rubber-flailed or metal-flailed spreaders produced acceleration in decomposition.","palabras_clave":"Rice harvest| Bearing capacity|Soil sustainability|Machinery traffic"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17259,"idioma_id":5,"titulo":"Eficiencia del cultivo bacteriológico y de la inmunofluorescencia en la detección de Campylobacter fetus en fluidos genitales bovinos","resumen":"Resumen La campilobacteriosis genital bovina es una enfermedad reproductiva que afecta la producción bovina. Es causada por las subespecies de Campylobacter fetus, C. fetus fetus (Cff) y C. fetus venerealis (Cfv). El objetivo de este estudio fue identificar la presencia de C. fetus en fluidos genitales mediante cultivo bacteriológico e inmunofluorescencia directa (IFD)y comparar los resultados. Se conformaron 2 grupos de 6 vaquillonas y 5 toros cada uno. Uno se infectó con Cff (grupo Cff) y el otro con Cfv (grupo Cfv). Dos vaquillonas y 2 toros sin infectar conformaron el grupo control. Periódicamente se tomaron muestras de mucus cervicovaginal y fluido prepucial, las que se procesaron por cultivo e IFD. En el grupo Cff se infectó el 100 % de las vaquillonas y el 80 % de los toros, mientras que en el grupo Cfv se infectó el 50 y el 60 %, respectivamente. Los valores de concordancia (Kappa) obtenidos al comparar las técnicas diagnósticas fueron de 0,57 para las vaquillonas del grupo Cff y 0,52 para las del grupo Cfv, y para los toros fueron de 0,17 y 0,27, respectivamente. En las vaquillonas, la IFD arrojó más resultados positivos que el cultivo, un 5,6 % más para el grupo Cff y un 7,4 % más para el grupo Cfv. El menor porcentaje de resultados positivos por IFD en los toros, un 40 % menos que por cultivo para el grupo Cff y un 5,3 % menos para el grupo Cfv, podría deberse a un muestreo incorrecto. Los valores de Kappa indican una concordancia moderada en las vaquillonas y baja en los toros.","palabras_clave":"CAMPYLOBACTER|BOVINOS|INMUNOFLUORESCENCIA|CULTIVO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17260,"idioma_id":4,"titulo":"Comparison of two chemical models to induce hepatic preneoplasia in male Wistar rats","resumen":"Background. One established model to induce hepatic preneoplasia (HP) (DEN 150) uses diethylnitrosamine (DEN) as initiator agent and 2-acetylaminofluorene (2-AAF) as a promoter drug. In addition, both chemicals cause liver cholestasis and fibrosis. Aim. We compared DEN 150 model with another adapted by us, DEN 200 to simplify the first one and to evaluate the effectiveness of both treatments to induce HP in rats. Material and Methods. Male Wistar rats were divided in 3 groups: controls; DEN150 (rats received 2 doses of DEN, 150 mg\/kg body weight, 2 weeks apart, and then 2-AAF, 20 mg\/kg body weight, 4 doses per week during 3 weeks); and DEN 200 (rats received a single dose of DEN 200 mg\/kg body weight, and 2 weeks apart and 2-AAF, 20 mg\/kg body weight, 2 doses per week during 3 weeks). Four hepatic enzymes, prothrombin time percentage, the number of bile ductules, total collagen amount, the number of altered hepatic foci (AHF) per liver and the percentage of liver occupied by foci were analyzed. Results. There were no differences in the number of AHF per liver between treated groups. Rats from DEN 200 group showed a significant diminution in the volume of liver occupied by foci. DEN 200 group had no fibrosis and better hemostatic conditions than DEN 150 group. Both groups developed cholestasis. Conclusion. In conclusion, both protocols are good alternatives to induce HP in rats and the new protocol proposed is an effective and a simple methodology to provide subclinic states of liver cancer.","palabras_clave":"diethylnitrosamine;|2-acetylaminofluorene|hepatocarcinogenesis|rat liver preneoplasia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17261,"idioma_id":4,"titulo":"Inflorescence Development in Abildgaardieae (Cyperaceae, Cyperoideae)","resumen":"Inflorescences in Cyperaceae are a source of characters with significant systematic value; however, thestructure and primary homologies pose a challenge to their interpretation. The relationships among mem-bers of Abildgaardieae are not clear due to the absence of a phylogeny with strong support, comprisinga representative number of species. Establishing correct primary homologies of inflorescences withinAbildgaardieae might help to clarify the relationships among its members, as well as to find synapo-morphies for the most important clades. Variations in the mature inflorescences within Abildgaardieaehave been related to their ?shape? and ?structure?, and preliminary phylogenetic studies in species ofBulbostylis have shown that inflorescence structure traits are phylogenetically informative, but this is nottrue for the mere shape. While similar structures in the adult inflorescences of the members of differ-ent clades within Abildgaardieae might be considered homologous, it must be ascertained whether suchsimilar structures share the same developmental process or have different developmental patterns. Bystudying the development of inflorescences in selected species of Abildgaardieae using SEM, we wereable to show that inflorescences with homologous structures share a similar developmental process and,therefore, the adult structure of inflorescences may be relied on for establishing correct primary mor-phological homologies in this plant group. Most structural variations of inflorescences in Abildgaardieaedepend on the degree of development of processes shared by the studied species. While phyllotaxisin the main axis of Cyperus may be modified during inflorescence development after primordial incep-tion, variations in the phyllotactic patterns of leaves on vegetative shoots (=nomophylls) and of leaveson fertile shoots (=bracts or hypsophylls) within Abildgaardieae, might establish deeper differences ininflorescence structure, since they depend on changes in the shape of the apical meristem.","palabras_clave":"ABILDGAARDIEAE |HOMOLOGY |INFLORESCENCE|MERISTEM|PHYLLOTAXIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17262,"idioma_id":4,"titulo":"Hepatic cyclooxygenase-2 expression protects against diet-induced steatosis, obesity and insulin resistance","resumen":"Accumulation evidence links obesity-induced inflammation asan important contributor to the development of insulin resistance, which playsa key role in the pathophysiology of obesity-related diseases such as type 2diabetes and nonalcoholic fatty liver disease. Cyclooxygenase (COX)-1 and -2catalyze the first step in prostanoid biosynthesis. Because adult hepatocytesfail to induce COX-2 expression regardless of the proinflammatory stimuli used,we have evaluated whether this lack of expression under mild proinflammatoryconditions might constitute a permissive condition for the onset of insulinresistance. Our results show that constitutive expression of human COX-2(hCOX-2) in hepatocytes protects against adiposity, inflammation, and, hence,insulin resistance induced by a high-fat diet, as demonstrated by decreasedhepatic steatosis, adiposity, plasmatic and hepatic triglycerides and freefatty acids, increased adiponectin-to-leptin ratio, and decreased levels ofproinflammatory cytokines, together with an enhancement of insulin sensitivityand glucose tolerance. Furthermore, hCOX-2 transgenic mice exhibited increasedwhole-body energy expenditure due in part by induction of thermogenesis andfatty acid oxidation. The analysis of hepatic insulin signaling revealed anincrease in insulin receptor-mediated Akt phosphorylation in hCOX-2 transgenicmice. In conclusion, our results point to COX-2 as a potential therapeutictarget against obesity-associated metabolic dysfunction.","palabras_clave":"COX-2|hepatocyte|HFD|obesity|IR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17263,"idioma_id":4,"titulo":"Resistance of functional Lactobacillus plantarum strains against food stress conditions","resumen":"The survival of three Lactobacillus plantarum strains (Lp 790, Lp 813 and Lp 998) with functional propertieswas studied taking into account their resistance to thermal, osmotic and oxidative stress factors.Stress treatments applied were: 52 Ce15 min (Phosphate Buffer pH 7, thermal shock), H2O2 0.1% (p\/v) e30 min (oxidative shock) and NaCl aqueous solution at 17, 25 and 30% (p\/v) (room temperature e 1 h,osmotic shock). The osmotic stress was also evaluated on cell growth in MRS broth added of 2, 4, 6, 8 and10% (p\/v) of NaCl, during 20 h at 30 C. The cell thermal adaptation was performed in MRS broth,selecting 45 C for 30 min as final conditions for all strains. Two strains (Lp 813 and Lp 998) showed, ingeneral, similar behaviour against the three stress factors, being clearly more resistant than Lp 790. Anevident difference in growth kinetics in presence of NaCl was observed between Lp 998 and Lp 813,Lp998 showing a higher optical density (OD570nm) than Lp 813 at the end of the assay. Selected thermaladaptation improved by 2 log orders the thermal resistance of both strains, but cell growth in presence ofNaCl was enhanced only in Lp 813. Oxidative resistance was not affected with this thermal pretreatment.These results demonstrate the relevance of cell technological resistance when selectingpresumptive ?probiotic? cultures, since different stress factors might considerably affect viability or\/andperformance of the strains. The incidence of stress conditions on functional properties of the strains usedin this work are currently under research in our group.","palabras_clave":"LACTOBACILLUS PLANTARUM|TECHNOLOGICAL STRESS|LACTIC ACID BACTERIA|CELL ADAPTATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17265,"idioma_id":4,"titulo":"Expression of conditioned preference for low-quality food in sheep is modulated by foraging costs","resumen":"Past positive experiences can increase herbivores? motivation to eat low-quality foods. However, this is not always translated into a higher preference for low-quality foods in choice tests among foods of higher nutritional quality. Foraging behavior is also affected by properties of the feeding context because the quality and abundance of foods in nature change in time and space. We hypothesized that in a choice situation, the expression of a past positive experience with a low-quality food is modulated by the costs associated with selecting a high-quality food option. Twenty-four sheep were randomly assigned into two groups (n=12). During conditioning phase, one group (CS+; i.e., conditioned group) was fed with oat hay (a low-quality food) for 20 min and immediately after a ration of soybean meal (a nutritious food), whereas the other group was also fed with oat hay but the offer of soybean meal was delayed 5 h (CS-; i.e., control group). After conditioning, we assessed sheep motivation to eat the oat hay in an experimental arena in which accessibility to alfalfa hay (a high-quality food) was increasingly restricted. When alfalfa hay was readily accessible, CS+ and CS- sheep almost exclusively selected this food, showing a small and similar preference for oat hay. However, when accessibility to alfalfa hay decreased, intake and selection of oat hay was greater in the CS+ sheep than in the CS- sheep. The latter was a consequence of differential changes in behavior between groups; for example, sheep in CS+ spent more time foraging oat hay and were more likely to switch to oat hay if they had previously been eating alfalfa hay than sheep in CS-. Our results show that behavioral expression of the conditioned preference for a low-quality food depends on parameters of the feeding context (e.g., availability). We suggest that this can be the link between learning models and optimal foraging models of diet selection.","palabras_clave":"LOW-QUALITY FOODS|LEARNING|FORAGING BEHAVIOR|DIET SELECTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17266,"idioma_id":4,"titulo":"SOX11 expression in chronic lymphocytic leukemia correlates with adverse prognostic markers","resumen":"The transcription factor SOX11 plays an important role in embryonic neurogenesis and tissue remodeling. Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. In this study, we have analyzed SOX11 transcription levels in 86 patients with diagnosis of chronic lymphocytic leukemia (CLL). Results were correlated with well known prognostic factors such as IGHV (immunoglobulin heavy chain variable) gene mutational status, cytogenetics risk groups and clinico-pathological characteristics of the disease. Overall, 35% of cases showed SOX11 expression meanwhile the remaining 65% lacked gene expression. The analysis taking into account the IGHV mutational status showed significant differences in SOX11 transcripts levels between mutated (0.004±0.0001) and unmutated CLL patients (0.405±0.011) (p&lt;0.0001), as well as a positive correlation between SOX11 mRNA expression and the percentage of IGHV homology (p=0.0001). Furthermore, significantly lower SOX11 mRNA expression was detected in patients with deletion 13q14 as a single alteration (0.016±0.008) than those observed in cases with deletions 11q\/17p (0.35±0.017) (p=0.02). The correlation of gene expression with clinical evolution showed shorter treatment free survival (p=0.043) and overall survival (p=0.047) in SOX11 positive patients compared to SOX11 negative cases. Our findings show for the first time an association between SOX11 expression and some CLL poor prognostic factors. These results suggest SOX11 as a possible biomarker that adds new biological information that could contribute to a better understanding of this pathology. ","palabras_clave":"Chronic lymphocytic leukemia|SOX11 gene expression|IGHV mutational status|FISH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17267,"idioma_id":5,"titulo":".'FORMULACIÓN DE ÍNDICE DE CALIDAD EDÁFICA PARA ARGIUDOLES DE LA CUENCA MEDIA DEL RÍO LUJÁN","resumen":"Para formular un índice de calidad edáfica (ICE) aplicable a Argiudoles, en la cuenca media del Río Luján, se trabajó sobre seis tratamientos ubicados en establecimientos agropecuarios: campo natural con mínima disturbación (md), siembra directa (SD), siembra directa subsolada (SDS), labranza reducida subsolada ( LRS), pastura(P) y labranza convencional con máxima disturbación (MD). En tres localizaciones por tratamiento se determinó: materia orgánica total (MO), biomasa microbiana (BM), densidad aparente (DAP), índice anisotrópico(IA), índice de inestabilidad de agregados (IS) e infiltración acumulada (INFac). Sobre los datos obtenidos se aplicó: análisis de varianza (ANVA), análisis de componentes principales (ACP) y funciones discriminantes canónicas (FDC). Los criterios para seleccionar indicadores fueron: importancia estadística en explicación de variabilidad, correlación positiva o negativa entre variables y complejidad de medición. ANVA indicó que las propiedades biológicas generaron el máximo de diferencias significativas entre tratamientos. ACP determinó autovalores y autovectores y  evaluó la relación entre propiedades y entre propiedades y tratamientos. Los autovalores de CP1 y CP2 (componentes principales) explicaron el 59% de variabilidad total. Los autovectores expresaron las mayores correlaciones positivas con CP1 para MO (0,57), BM (0,48), INFac (0,48) e IA (0,41) y su mayor sensibilidad a cambios según uso y manejo. DAP e IS se desestimaron por valores bajos de autovectores y BM por medición compleja. Se seleccionaron MO (alta correlación positiva con BM), INFac e IA. Aplicando análisis discriminante lineal (ADL) a las propiedades seleccionadas se obtuvo el ICE=-8,08+2,27*MO+0,16*IA+0,01*INFac. ICE para cada tratamiento determinó una secuencia decreciente ligada al grado de remoción del suelo (md, P, SDS, SD, LRS, MD), consistente con evidencia disponible y más allá de diferencias dentro de Argiudoles. La ubicación de tratamientos por ACP en diferentes cuadrantes generó tres grupos según intensidad de la labranza: SD y SDS, md y P y MD y LRS, compatible con el generado por FDC.","palabras_clave":"CALIDAD DE SUELOS|ANÁLISIS DE COMPONENTES PRINCIPALES|FUNCIONES DISCRIMINANTES CANÓNICAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17268,"idioma_id":4,"titulo":"Study on Perspectives Regarding Deposit on Open Access Repositories in the Context of Public Universities in the Central-Eastern Region of Argentina.","resumen":"This article presents the results of a survey and qualitative study of needs and practices of open access scholarly works dissemination. The survey and study focused on different issues related to usability, navigation, and accessibility of institutional repositories, which have guided the design of an experimental prototype in the context of a regional project that joins three universities in Argentina. In such academic practices, the teaching community offers various types of production and simultaneous application areas for digital objects. Thus, there is a technological requirement to enable users to carry out their self-archiving process of different objects, in a user-friendly way, allowing them to upload these objects in various collections. A prototype was implemented and tested in order to obtain an initial assessment of the proposed model.","palabras_clave":"HIGHER EDUCATION|OPEN ACCESS REPOSITORIES|EDUCATIONAL DIGITAL OBJECTS|DSPACE|PROFESSORS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17269,"idioma_id":4,"titulo":"Highway network expansion in Andean Patagonia: a warning notice from Rufous-legged owls","resumen":"As part of the economic and population growth of Patagonia, several dust\/gravel roads crossing well preserved Andean forests are being converted into paved highways. The potential effects of these changes on forest wildlife have been little studied. The Rufous-legged Owl (Strix rufipes) was dominant among road-killed birds in our survey of a 27-km section of highway running through forests of Nahuel Huapi National Park, in Argentine Patagonia. Fatalities were not evenly distributed along the surveyed length of the road, so we investigated whether landscape features, roadside slope on both sides of the highway, demography, and\/or season explained the aggregation pattern. Patterns of distribution of theroad-killed owls were explained by owl abundance and age-class, time of year, and hour, and were weakly related to canopy closure; roadside slope on both sides was unrelated to abundance of fatalities. Trafficrelated deaths were likely the primary cause of non-natural mortality of Rufous-legged Owls (especially for young individuals) in the study area. Examination of carcasses indicated that most owls were killed by turbulence behind large vehicles and that deaths occurred early in the night. Semi-trailer trucks capable of carrying large loads, which peak in numbers between dusk and midnight, likely caused most&nbsp; fatalities. A wayto reduce owl mortality could be to schedule truck traffic outside the hours when owls are most active at hunting around paved roads crossing natural forests, at least during late winter and spring seasons. Because transportation networks encourage future development that will affect the environment in a variety of ways, it is critical to retain roadless and near-roadless (i.e., having only dirt or gravel roads with slow-moving traffic) portions of the southern Andes to preserve their natural landscapes.","palabras_clave":"Strix rufipes|forest habitat|night traffic|roadkills"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17270,"idioma_id":4,"titulo":"Levo-1-methyl tryptophan aggravates the effects of mouse hepatitis virus (MHV-A59) infection","resumen":"Mice infected with mouse hepatitis virus A59 (MHV-A59) develop autoantibodies (autoAb)  to liver and kidney fumarylacetoacetate hydrolase (FAH) with a concomitant enhancement of  transaminases and release of alarmins such as uric acid and high-mobility group box protein 1  (HMGB1).  Tryptophan catabolism is an endogenous mechanism that restricts excessive immune  responses, thereby preventing immunopathology. Since indoleamine-2,3-dioxygenase (IDO) is the  key and rate-limiting enzyme of tryptophan catabolism, the aim of this work was to explore whether  specific inhibition of IDO by Levo-1-methyl tryptophan (MT) could affect MHV actions.  Results showed that MT strongly enhanced the hypergammaglobulinemia induced by the  virus, as well as anti-MHV Ab and uric acid release. Moreover, infected mice treated with MT did  express anti-FAH autoAb and high levels of serum HMGB1. Survival of MHV-infected animals  treated with MT was severely reduced compared with that of MHV-infected mice or controls only  treated with MT. Furthermore, histological liver examination indicated that MT induced fibrosis in  MHV-infected animals, whereas MT itself increased uric acid levels without shortening the animal  life Thus, under our experimental conditions, results indicated an exacerbated response to MHV  infection when IDO was blocked by MT.","palabras_clave":"HMGB1|indoleamine-2,3-dioxygenase|Levo-1-methyl tryptophan|uric acid"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17271,"idioma_id":5,"titulo":"Modulación de la respuesta a insulina en el ovario bovino y su relación con la enfermedad quística ovárica","resumen":"La enfermedad quística ovárica bovina es una importante enfermedad que afecta la fertilidad del ganado bovino lechero. Diversos procesos ováricos tales como la proliferación celular y la esteroidogénesis se encuentran regulados por numerosas hormonas entre las que se encuentra la insulina. La respuesta a esta hormona se desencadena luego de la unión a su receptor específico. El objetivo de la presente revisión es analizar la función de intermediarios claves en la vía de señalización intracelular, que actúan enlos primeros estadios involucrados en la respuesta a insulina. Se analizan elreceptor de insulina (IR), el sustrato -1 del IR (IRS1) y la enzima fosfatidilinositol 3-quinasa (PI3K) denotando modificaciones ocurridas en folículos quísticos que podrían influenciar negativamente en la funcionalidad de ovarios y contribuir a la persistencia folicular. ","palabras_clave":"INSULINA|OVARIO|BOVINOS|ENFERMEDAD QUISTICA OVARICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17272,"idioma_id":4,"titulo":"Pedagogically-driven Ontology Network for Conceptualizing the e-Learning Assessment Domain","resumen":"The use of ontologies, as tools to guide the generation, organization and personalization of e-learning content including e-assessment, has drawn attention of the researchers because they can represent the knowledge of a given domain and then use the ontology to reason about it. Although the use of these semantic technologies tend to enhance technology based educational processes, the lack of validation to improve the quality of learning in their use, makes the educator feel reluctant to use it. This paper presents progress in the development  of an ontology network, called AONet, that conceptualizes the e-assessment domain with the aim of supporting the semi-automatic generation of assessment, taking into account not only technical aspects but also pedagogical ones.","palabras_clave":"ontology|ontology network|e-learning|e-assessment"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17273,"idioma_id":5,"titulo":"Calidad de Vida Urbana en la Argentina de la postconvertibilidad.  Procesos sociales y territoriales en el período 2003-2012","resumen":"    El objetivo del presente trabajo consiste en indagar  los niveles de calidad de vida de la población urbana en Argentina entre 2003 y  2012, período signado por la implementación de un modelo de crecimiento  denominado Posconvertibilidad, Neodesarrollismo o Posneoliberalismo, para reconocer  sus efectos en la evaluación del bienestar de sus habitantes. Con tal fin se  elabora un índice de calidad de vida de implantación puntual aplicado a las  ciudades donde se releva la Encuesta Permanente de Hogares (EPH-INDEC), cuyas bases  de datos corresponden a 32 aglomerados urbanos. El análisis se complementa con  la búsqueda de la asociación estadística entre los niveles de calidad de vida y  la distribución del ingreso en las ciudades incorporadas a la consulta de la  EPH. Por tanto, el análisis pretende contribuir al conocimiento de las  disparidades socio-territoriales entre las aglomeraciones urbanas, en el marco  de procesos sociales, económicos, políticos y culturales, que prefigurarían  cambios importantes en el bienestar de los hogares argentinos a lo largo de los  últimos diez años.   ","palabras_clave":"CALIDAD DE VIDA|AGLOMERADOS URBANOS|ENCUESTA PERMANENTE DE HOGARES|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17274,"idioma_id":4,"titulo":"A kinetic theory approach to the dynamics of crowd evacuation from bounded domains","resumen":"A mathematical model of the evacuation of a crowd from bounded domains is derived by a hybrid approach with kinetic and macro features. Interactions at the micro-scale, which modify the velocity direction, are modeled by using tools of game theory and are transferred to the dynamics of collective behaviors. The velocity modulus is assumedto depend on the local density. The modeling approach considers dynamics caused by interactions of pedestrians not only with all the other pedestrians, but also with the geometry of the domain, such as walls and exits. Interactions with the boundary of the domain are non-local and described by games. Numerical simulations are developed to study evacuation time depending on the size of the exit zone, on the initial distribution of the crowd and on a parameter which weighs the unconscious attraction of the stream and the search for less crowded walking directions.","palabras_clave":"CROWD DYNAMICS|COMPLEX SYSTEMS|HYBRID MODEL|NONLINEAR INTERACTIONS|STOCHASTIC GAMES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17275,"idioma_id":4,"titulo":"Non-Genomic Actions of Estradiol and 4-OH-Tamoxifen on Murine Breast Cancer Cells","resumen":"Estrogens and tamoxifen do not only exert their effects at the genomic level, but also play a role at the cell membrane activating downstream signaling pathways. We recently characterized an estrogen receptor-positive epithelial murine breast cancer cell line,&nbsp; LM05-E. Utilizing this cell line and MCF-7 cells, we compared the non-genomic effectsof estradiol and 4-OH-tamoxifen. We showed that, similar to estradiol, tamoxifen activated the MAPK\/ERK 1\/2 pathway; however, we did not find activation of PI3K\/AKT by eitherestradiol or tamoxifen. Short-term treatments with estradiol stimulated, whereas tamoxifen inhibited cell proliferation.Using pharmacological inhibitors we showed that the effect of estradiol was mediated by the MAPK\/ERK 1\/2 pathway, but that inhibition of this pathway did not affect tamoxifen.Surprisingly, however, blocking of PI3K\/AKT signaling interfered with the inhibitory effect of tamoxifen. Analysis of the involvement of the EGFR support previous findings that designate this receptor as a mediator of the non-genomic effects of estradiol; blocking EGFR also reverses the inhibitory effect of tamoxifen. Finally, matrix metalloproteinases (MMPs) were confirmed to be involved in the proliferative effect of estradiol. These results demonstrated the novel non-genomic effects of tamoxifen and revealed that pathways downstream of EGFR and PI3K\/AKT are involved in the inhibition of cell proliferation. Caution should be exercised when analyzing strategies that aim at combining endocrine therapy with specific signaling inhibitors","palabras_clave":"BREAST CANCER CELL LINES|ESTRADIOL|TAMOXIFEN|NON GENOMIC PATHWAYS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17276,"idioma_id":4,"titulo":"The spontaneous room temperature reduction of HAuCl4 in ethylene glycol in the presence of ZnO : a simple strategy to obtain stable Au\/ZnO nanostructures exhibiting strong surface plasmon resonance and efficient electron storage properties.","resumen":"The room temperature spontaneous reduction of HAuCl4 in ethylene glycol in the presence of pre-formed ZnO nanoparticles is investigated by UV-vis spectroscopy. Analysis by HRTEM demonstrated that the synthesized nanostructures consist of small ZnO nanoparticles (5.0 nm) in contact with bigger (15 nm) spherical Au nanoparticles. The electronic communication between Au and ZnO blocks is  confirmed by UV excitation of the colloid. These experiments indicate that ZnO nanoparticles efficiently transfer the electrons to Au nanoparticles in contact, inducing a 15 nm blue shift in the plasmon band. Titration experiments using the methylviologen couple (MV2+\/MV+) are presented and analyzed to quantify the enhancement in the electron storage capability in the new nanostructure and the negative shift in the Fermi level caused by the Au loading in ZnO.","palabras_clave":"Au-ZnO nanostructures|plasmon"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17277,"idioma_id":4,"titulo":"Effect of crab bioturbation on organic matter processing in South West Atlantic intertidal sediments","resumen":"Organic matter (OM) remineralization plays a key role in controlling the biogeochemistry of marine sediments. Through their burrowing activities, bioturbating macrofauna not only induces physical, chemical and biological modifications, which can affect microbial communities responsible for organic matter remineralization, but it could also directly affect the distribution and bioavailability of sedimentary organic matter. Through in situ experiments manipulating crab and burrow density in intertidal soft-bottoms, we assessed if crab-bioturbation affects benthic metabolism, and the amount, distribution, and bioavailability of sedimentary OM. Crab-bioturbation enhanced overall benthic metabolism and benthic flux of dissolved OM toward the water column at both mudflat and saltmarsh zones. Moreover, our results revealed that bioturbation also changes the quality, bioavailability and distribution of sedimentary OM in mudflats and saltmarshes. Overall, bioturbation enhanced the proportion of labile organic carbon of bioturbated sediments and homogenized the sediment column in terms of their proportion of labile organic carbon. However, crabs also generated biogenic structures (e.g., mounds) that could promote spatial heterogeneity of high nutritional-value OM. Bioturbation-induced changes on benthic metabolism and on OM availability would result in a reduction of the storage capacity of carbon in our intertidal systems. Previous works indicated that crab-burrows trap detritus and OM-rich sediments. Our results suggest that detritus are efficiently remineralized at bioturbated sediment, and finally they are quickly exported to the water column as CO2 and DOC. Thus, crabs are modifying the OM processing at intertidal soft bottoms, and the ways in which carbon is exported to coastal waters.","palabras_clave":"biogeochemical cycles|bioturbation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17278,"idioma_id":4,"titulo":"Mass Spectral Study of the Occurrence of Tautomeric Forms of Selected Enaminones","resumen":"The mass spectra of enaminones can provide valuable information with regards to tautomeric equilibria in the gas phase. Mass spectra of selected enaminones have been analyzed and specific fragmentation assignments have been done to characterized and weigh co-existing all possible tautomers of enaminones. Thioenaminones are of particular interest due to their tendency to shift the tautomeric equilibrium towards the thioenolimine or thioenolenamine form. Mass spectra of differently substituted enaminones are examined looking for common mass spectral behaviors. Ion fragmentations from specific tautomers allow predicting the most stable structure for the selected compounds. Acceptable correlation between the experimental data and theoretical results are found only with the neutral species, indicating that mass spectrometry could be resourced as a tool for the investigation of tautomerism of neutral species in the gas phase.","palabras_clave":"Enaminones|Tautomerism|Mass spectrometry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17279,"idioma_id":5,"titulo":"Estudios sobre el comportamiento de forrajeo de Acromyrmex lundi Guering (Hymenoptera, Formicidae) y su efecto sobre el crecimiento de Eucalyptus globulus Labill. (Myrtaceae).","resumen":"El ataque de las hormigas cortadoras es una de las principales razones de pérdida de plantas durante la etapa de establecimiento de un monte forestal. Los objetivos de este estudio fueron evaluar la intensidad de forrajeo de Acromyrmex lundi asociado a algunas condiciones ambientales y procedencias de Eucalyptus globulus y estimar el impacto de la herbivoría sobre el crecimiento inicial de estos árboles. Dos ensayos se llevaron a cabo durante dos temporadas estivo-otoñales consecutvas, en el Campo Experimental de la Universidad Nacional de Luján, Argentina. Los materiales de diferentes procedencias fueron dispuestos en bloques equidistantes a 5 m de un nido activo de A. lundi. Durante doce semanas se contabilizó el número de hojas cortadas por las hormigas y se registraron algunas variables meteorológicas. En el segundo año la mitad de las parcelas fue protegida de las hormigas y se midieron variables de crecimiento. Los materiales de todas las procedencias fueron atacadas por A. lundi, aunque el número de hojas cosechada fue significativamente diferente sólo entre los orígenes Flinders Island (52,5 hojas) y Nullo Mountain (28,5 hojas). El número de días lluviosos fue el único factor ambiental que se relacionó positivamente con la actividad de las hormigas. Todos los tratamientos redujeron significativamente la altura, el diámetro y el área foliar cuando fueron atacados por las hormigas. Las distintas procedencias compensaron diferencialemnte la herbivoría. Se discuten los resultados en función de los criterios a tener en cuenta para la selección de materiales genéticos como herramienta de manejo y control del ataque de A. lundi.","palabras_clave":"Hormigas podadoras|Eucaliptos|Vivero forestal"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17280,"idioma_id":5,"titulo":"La responsabilidad social como instrumento de anticipación a conflictos sociales y ambientales","resumen":"En 2005, la Organización Internacional de Normalización (ISO), ante la multiplicidad de herramientas de responsabilidad social (RS) existentes y reconociendo la importancia y complejidad de la temática, consideró pertinente desarrollar una Norma Internacional que brindara un entendimiento común en la materia.  La norma ISO 26000 ofrece orientación sobre la integración de la RS a las organizaciones públicas y privadas de todo el mundo y es resultado del consenso internacional logrado por los representantes de los principales grupos de interés en materia,  En la introducción establece que el objeto de la RS es ayudar a las organizaciones a contribuir al logro del desarrollo sustentable.  Reconociendo los impactos que las decisiones y actividades de una organización ocasionan en la sociedad y el ambiente, y los consecuentes conflictos que se pudieran generar, la ISO 26000 propone,  desde la propia definición de RS,  un comportamiento que tome en consideración las expectativas de sus partes interesadas.  Uno de los principios textualmente expresa: ?una organización debería respetar, considerar y responder a los intereses de sus partes interesadas?, que no son solo ?sus dueños, socios, clientes o integrantes?, sino que comprenden otros individuos o grupos, cuyos derechos, reclamaciones o intereses específicos deberían considerarse.  Según la norma, la identificación e involucramiento con las partes interesadas son clave para abordar la RS de una organización.  El involucramiento incluye el diálogo entre la organización y una o más de sus partes interesadas, como metodología para reconciliar  conflictos que impliquen sus propios intereses, los de sus partes interesadas y las expectativas de la sociedad como un todo y para atender intereses en conflicto.   Luego de abordar los principios, materias fundamentales y asuntos de RS, el capítulo 7 -que ofrece orientación sobre la integración de la RS en toda la organización-  incluye el acápite 7.6.3 específicamente referido a la resolución de conflictos o desacuerdos entre una organización y sus partes interesadas. Allí se propugna que la organización tenga a disposición de las partes interesadas, información detallada sobre los procedimientos disponibles para resolver conflictos y desacuerdos.   Sin lugar a dudas, la Norma Internacional ISO 26000:2010-Guía de responsabilidad social -herramienta poderosa para ayudar a las organizaciones a pasar de las buenas intenciones a las buenas acciones en materia de RS-  a partir de su enfoque, que parte del reconocimiento inicial de las expectativas de las partes interesadas, se constituye en  un instrumento de anticipación a los conflictos, en el mundo globalizado.","palabras_clave":"Desarrollo sustentable|Responsabilidad social|Ambiente|Conflicto"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17281,"idioma_id":4,"titulo":"Integrin alphaVbeta3 acting as membrane receptor for thyroid hormones medi","resumen":"The interaction of lymphoid tumor cells with components of the extracellular matrix via the integrin &#945;v&#946;3 allows tumor survival and growth. This integrin was demonstrated to be the membrane receptor for thyroid hormones in several tissues. We found that thyroid hormones (THs), acting as soluble integrin &#945;v&#946;3 ligands, activated growth-related signaling pathways in T-cell lymphomas (TCL). Specifically, TH-activated &#945;v&#946;3 integrin signaling promoted TCL proliferation and angiogenesis, in part, via the up-regulation of VEGF. Consequently, genetic or pharmacologic inhibition of integrin &#945;v&#946;3 decreased VEGF production and induced TCL cell death in vitro and in human xenografts models. In sum, we here show that integrin &#945;V&#946;3 transduces pro-survival signals into TCL nuclei, suggesting a novel mechanism for the endocrine modulation of TCL pathophysiology. Targeting this mechanism could constitute an effective and potentially low-toxicity chemotherapy-free treatment for TCL patients.","palabras_clave":"T cell lymphoma|Integrin alphaVbeta3|thyroid hormones|angiogenesis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17282,"idioma_id":4,"titulo":"Optimization of the formulation of nutritional breads based on calcium carbonate and inulin","resumen":"The purpose of this work was to optimize nutritional wheat bread formulation based on calcium carbonate and inulin (In); and to study dough fermentation properties and bread quality. During fermentation, time (tf) and dough volume (Vmax) were analyzed. Specific volume (Vs), crust colour, moisture, texture and alveolus properties of crumb are studied. Dough with high In content experienceda fast although less expansion. Furthermore, calcium fortification decreased tf. Crust colour was dependent on inulin content. At 13 g\/100 g In, the lowest dough Vmax but the highest Vs bread was obtained. Crumb firmness and chewiness increased with 6.5 g\/100 g In although high level of prebiotic did not modify these parameters. At the same In quantity, an increase of calcium carbonateresulted on softer and more elastic crumbs. Crumb moisture, decreased with the increment of prebiotic. Without In and in the presence of Ca, crumbs presented low alveolus area. The highest Vs of 13 g\/100 g In breads was due to the high number of alveolus with a large void area. Based on the response surface of multiples variables (moisture, cohesiveness, chewiness, Vs) was optimized using a desirability function; the optimum calcium-prebiotic fortified bread obtained was that one that contained 2.196 g\/kg Ca and 9.635 g\/100 g In.","palabras_clave":"WHEAT FLOUR|CALCIUM CARBONATE|INULIN|OPTIMUM BREAD QUALITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17283,"idioma_id":4,"titulo":"Enhancement of ionizing radiation response by histamine in vitro and in vivo in human breast cancer","resumen":"The radioprotective potential of histamine on healthy tissue has been previouslydemonstrated. The aims of this work were to investigate the combinatorial effect of histamine or its receptor ligands and gamma radiation in vitro on the radiobiological response of 2 breast cancer cell lines (MDA-MB-231 and MCF-7), to explore the potential molecular mechanisms of the radiosensitizing action and to evaluate the histamine-induced radiosensitization in vivo in a triple negative breast cancer model. Results indicate that histamine significantly increased the radiosensitivity of MDA-MB-231 and MCF-7 cells. This effect was mimicked by the H1R agonist 2-(3-(trifluoromethyl)phenyl)histamine and the H4R agonists (Clobenpropit and VUF8430) in MDA-MB-231 and MCF-7 cells, respectively. Histamine and its agonists enhanced radiation-induced oxidative DNA damage, DNA double-strand breaks, apoptosis and senescence. These effects were associated with increased production of reactive oxygen species, which correlated with the inhibition of catalase, glutathione peroxidase and superoxide dismutase activities in MDA-MB-231 cells. Histamine was able also to potentiate in vivo the anti-tumoral effect of radiation, increasing the exponential tumor doubling time. We conclude that histamine increased radiation response of breast cancercells, suggesting that it could be used as a potential adjuvant to enhance the efficacy of radiotherapy.","palabras_clave":"Apoptosis|Histamine receptor |Ionizing Radiation|Radiotherapy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17284,"idioma_id":5,"titulo":"CADENA ESPÁRRAGO: PRODUCCIÓN DE DIFERENTES GENOTIPOS EN SU QUINTO AÑO Y COMPORTAMIENTO EN POSCOSECHA","resumen":"Cadena espárrago: producción de diferentes  genotipos en su quinto año y comportamiento en  poscosecha. El objetivo del presente trabajo fue evaluar el  rendimiento de primicia de cosecha en invernadero, de tres  genotipos de espárrago, en su quinta temporada. El ensayo  se inició en la Facultad de Ciencias Agrarias, UCA, en  Buenos Aires, el 15 de noviembre de 2006. En la presente  evaluación se efectuaron diecinueve cosechas manuales, del  4 de setiembre de 2012 al 22 de octubre de 2012, cada dos  días. Se realizó un análisis multifactorial ANOVA-LSD test  (p>0,05). Se evaluó la productividad total y comercial (PFT  y PFC), número de turiones totales y comerciales\/ha (NTT  y NTC), distribución de calibres (DC): jumbo (J), extralarge  (XL), large (L), medium (M) y small (S); y defectos  encontrados (D): espigados (TE), cortos (TC) y otros  defectos (OD). En poscosecha se evaluaron: atados (A),  bandejas (BA) y bolsas de polietileno (BO), para determinar  la evolución del peso fresco (EPF), pérdida diaria de peso  fresco (PPFD) y peso fresco promedio del período de  poscosecha (PPFP). Los genotipos italianos superaron las 9  t\/ha, valor que duplica la media nacional argentina superando  a UC-157. En producción, se destacó Giove en PFT, PFC,  NTT, NTC y una DC favorable, con un 70% de los turiones  L y XL. Con respecto al comportamiento en poscosecha, se  evidenció que el menor grado de deshidratación se obtuvo  mediante el empleo de bolsas y bandejas en el envasado.","palabras_clave":"INVERNADERO|TURIONES|PRODUCCION|CALIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17285,"idioma_id":5,"titulo":"Produccion de primicia de híbridos de espárrago verde (Asparagus officinlis var. Altitis) en su cuarto año productivo","resumen":"La producción de espárragos en Argentina está caracterizada por una elevada  estacionalidad concentrada en el periodo octubre-diciembre, por lo que el empleo de invernaderos brinda la posibilidad de ampliar el calendario de oferta, anticipando la entrada en producción. Con el objetivo de evaluar el rendimiento de primicia de diferentes híbridos de espárrago verde, se realizó un ensayo en invernadero con ocho híbridos, en UCA Buenos Aires, iniciado el 15\/11\/2006,  mediante  plantines  de  100  díasa  1m*0,3m.  Se  evaluaron  los  siguientes genotipos: Italo, Zeno, Eros, Ercole, H-668, Marte, y Giove, de origen italiano, y UC-157 de origen  americano,  como  testigo  por  ser  el  tradicionalmente  cultivado  en  Argentina.  Se evaluaron 22 cosechas, con una frecuencia de día por medio, del 17\/08\/2011-25\/10\/2011. Seestudiaron  diferencias  en  kg  totales  y  comerciales  (PFT  y PFC),  Nº  turiones  totales  y comerciales\/ha (NTT y NTC) y distribución de calibres (DC): Jumbo (J), Extra-Large (XL), Large (L), Medium (M), Small (S) y Asparagina (A). Se efectuó un análisis multifactor ANOVA LSD test (P>0.05). En promedio se obtuvieron: PFT: 17053; PFC: 7904 kg.ha-1; NTT: 670566 y NTC: 520938 turiones.ha-1. Se destacaron: en PFT: Italo: 29456 (a), Zeno: 23056 (b), Giove: 23034 (b) y H-668: 18568 (bc); en PFC: Italo: 14850 (a), Giove: 9856 (b), Zeno: 9130 (bc) y H-668: 8228 (bcd); en NTT: Italo: 842512 (a), H-668: 754512 (a), Giove: 715000 (b) y Eros: 707498 (b); en NTC: Italo: 844998 (a), H-668: 667502 (b) y Eros: 542498 (bc) y en DC: en J: Italo (a), Giove (b), Zeno (bc) y UC-157 (bcd); en XL: Italo (a), Zeno (ab)y Giove (b); en L: Giove (a), Italo (a), Zeno (ab), H-668 (abc) y UC-157 (abc); en M: Italo (a), H-668 (ab) y Eros (ab); en S: H-668 (a), Eros (a) e Italo (ab) y en A: H-668 (a) y Marte (ab). Por lo expuesto resulta alentadora la productividad de Italo, iove, Zeno y H-668 para producción de espárrago verde de primicia en invernadero.","palabras_clave":"ASPARAGUS OFFICINALIS|PRIMICIA|INVERNADERO|PRODUCTIVIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17286,"idioma_id":4,"titulo":"Sex determination in fish: Odontesthes spp.  (Atherinopsidae) as experimental models.","resumen":"The sex of the offspring is the result of a unique process leading, in a binary fate, to the development of male or female characteristics.  In this context, the aim of the present work is to present atherinopsid   fish as excel lent models to  study  sex determination. Here we present two atherinopsid fish from South America; one species,  Odontesthes bonariensis , has a strong temperature -dependent sex dete rmination (TSD) and the other,  Odontesthes hatchery, has a genotypic sex determination (GSD). However, the  results  obtained in the last years from  our laboratories in  both species  show that the boundaries between  these two sex determination mechanisms with in Atherinopsidaeare  are  not as rigid as previously thought and   support the notion that TSD and GSD are the extremes of a continuum.","palabras_clave":"GSD|Odontesthes|sex determination|TSD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17287,"idioma_id":4,"titulo":"Screening concentration of E1, E2 and EE2 in sewage effluent and surface waters of the 'Pampas' region and the 'Río de la Plata' estuary (Argentina)","resumen":"Concentrations of estrone (E1), 17&#946;-estradiol (E2) and 17&#945;-ethinylestradiol (EE2) were investigated for the first time in sewage effluents and receiving waters of the ?Río de la Plata? estuary and neighboring areas by means of LC-MS\/MS. E2 and EE2 were ubiquitous in the evaluated sewage effluent samples showing concentrations ranging between 122-631 and 65-187 ng\/L, respectively. In surface waters, these estrogens were only detected in the ?Girado? stream (Chascomús) at 369 and 43 ng\/L, respectively. No significant relationship was found among the size of the served population and the concentration of the estrogens in the sewage effluent. The detection of these estrogens in receiving waters was dependent on the dilution capacity of the system. The studied estrogens were undetectable at the La Plata City water supply station. Conversely, concentrations found at the ?Girado? stream indicate a potential ecotoxicological risk of these estrogens to the local aquatic biota.","palabras_clave":"Water quality|Endocrine disruptors|South America|LC-MS\/MS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17288,"idioma_id":4,"titulo":"One dimensional speckle fields generated by three phase level diffusers","resumen":"Speckle patterns have usually been obtained by using ground glass as random diffusers. Liquid-crystal spatial light modulators have opened the possibility of engineering tailored speckle fields obtained from designed diffusers. In this work, one-dimensional Gaussian speckle fields with fully controllable features are generated. By employing a low-cost liquid-crystal spatial light modulator, one-dimensional three phase level diffusers are implemented. These diffusers make it possible to control average intensity distribution and statistical independence among the generated patterns. The average speckle size is governed by an external slit pupil. A theoretical model to describe the generated speckle patterns is developed. Experimental and theoretical results confirming the generation of one-dimensional speckle fields are presented. Some possible applications of these speckles, such as atom trapping and super-resolution imaging, are briefly envisaged.","palabras_clave":"SPECKLE|SPATIAL LIGHT MODULATOR|LIQUID CRYSTAL DEVICES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17289,"idioma_id":4,"titulo":"Effect of Temperature on the Crevice Corrosion of Nickel Alloys Containing Chromium and Molybdenum","resumen":"Chloride-induced crevice corrosion of alloys 625, C-22, C-22HS and HYBRID-BC1 was studied at different temperatures. Crevice corrosion occurred tens of degrees below the reported critical crevice temperatures obtained through standard immersion tests. Concentrated calcium and sodium chloride solutions showed the same aggressiveness regarding crevice corrosion behavior of alloys C-22 and HYBRID-BC1. The crevice corrosion repassivation potential decreased as the temperature and chloride concentration increased. For alloys 625 and C-22, the repassivation potential reached a minimum limiting value which was coincident with the corrosion potential in the crevice-like solution. For alloys C-22HS and HYBRID-BC1, these conditions are expected to be reached above the tested temperatures. The high dependence of the repassivation potential on chloride concentration was attributed to the ohmic potential drop caused by passivating species at the alloy\/solution interface. A temperature dependence of 4-9 mV\/K was observed for the repassivation potential in dilute chloride solutions while it decreased to 2-3 mV\/K in concentrated chloride solutions. In the context of the localized acidification model, the corrosion potential in the crevice-like solution did not depend on  the temperature while the anodic polarization to maintain the crevice acidity and the ohmic potential drop decreased linearly as temperature increased.","palabras_clave":"CREVICE CORROSION|TEMPERATURE|NICKEL ALLOYS|CHLORIDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17290,"idioma_id":4,"titulo":"Anodic stress corrosion cracking susceptibility of nickel and nickel-chromium alloys containing molybdenum and iron in bicarbonate plus chloride solutions at 90°C","resumen":"It is reported in the literature that alloy C-22 (N06022) was found to be susceptible to stress corrosion cracking (SCC) in presence of bicarbonate ions, at temperatures higher than 60°C and anodic applied potentials in the order of 400 mVSCE, (where SCE is the saturated calomel electrode) when using slow strain rate tests (SSRTs). This potential range of cracking susceptibility was associated with the instability of a film that may form on the surface. In order to elucidate the role of the alloying elements on the SCC susceptibility of nickel (Ni)-based alloys, four alloys?C-22 (N06022), 600 (N06600), 800H (N08800) and Ni-201 (N02201)?were tested under the same conditions. Results showed that even though C-22, 600, and 800 may have similar electrochemical anodic behavior, only C-22 may present a clear case of SCC at anodic potentials.","palabras_clave":"NICKEL ALLOYS|STRESS CORROSION CRACKING|BICARBONATE|CHLORIDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17291,"idioma_id":4,"titulo":"WEAR RESISTANCE OF ANODIC TITANIUM DIOXIDE NANO-COATINGS PRODUCED ON Ti-6Al-4V ALLOY","resumen":"Ti-6Al-4V alloy with TiO 2 coating is the most commonly selected material to construct an aortic heart valve. Wear resistance is the main mechanical property to be evaluated for this purpose. In this paper, the wear resistance of TiO 2 thin films obtained by anodic oxidation of Ti-6Al-4V is evaluated. Anodic oxidation was performed at 20 V to 70V with a H 2 SO 4 1 M electrolyte. The samples were thermally treated at 500°C for 1 h, and crystalline phases of TiO 2 were obtained. The wear was performed in a ball-on-flat recip&#8208; rocating machine with a range of loads from 1 g f to 4 g f and times between 60 s and 1200 s, using a diamond sphere as counterface. The counterface oscillates at 0.5 Hz and 4 mm in amplitude. The wear is measured using a profilometerand is calculated as the worn volume. The wear resistance of the coated samples is larger than the substrate, and increases with thickness and with crystalline coating.","palabras_clave":"Titanium dioxide|coatings"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17292,"idioma_id":4,"titulo":"A review of the OECD Income Distribution Database","resumen":"The OECD Income Distribution Database is a valuable data resource that greatly contributes to the study of income inequality and poverty in the OECD countries. In this review we expose this database to critical scrutiny from the standpoint of the potential user, identifying their strengths and weaknesses.","palabras_clave":"INEQUALITY|OECD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17293,"idioma_id":4,"titulo":"Inhibition of the PI3K\/Akt pathway by Ly294002 does not prevent establishment of persistent Junin virus infection in Vero cells","resumen":"In previous work, we demonstrated that the arenavirus Junín virus (JUNV) is able to activate Akt by means of the phosphatidylinositol-3-kinase (PI3K) survival pathway during virus entry. This work extends our study, emphasizing the relevance of this pathway in the establishment and maintenance of persistent infection in vitro. During the course of infection, JUNV-infected Vero cells showed a typical cytopathic effect that may be ascribed to apoptotic cell death. Treatment of infected cultures with Ly294002, an inhibitor of the PI3K\/Akt pathway, produced an apoptotic response similar to that observed for uninfected cells treated with the drug. This result suggests that virus-induced activation of the PI3K\/Akt pathway does not deliver a strong enough anti-apoptotic signal to explain the low proportion of apoptotic cells observed during infection. Also, inhibition of the PI3K\/Akt pathway during the acute stage of infection did not prevent the establishment of persistence. Furthermore, treatment of persistently JUNV-infected cells with Ly294002 did not alter viral protein expression. These findings indicate that despite the positive modulation of the PI3\/Akt pathway during Junín virus entry, this would not play a critical role in the establishment and maintenance of JUNV persistence in Vero cells.","palabras_clave":"JUNIN VIRUS|PERSISTENT INFECTION|PI3K Akt"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17294,"idioma_id":4,"titulo":"Preliminary results of the Fourth International Asparagus Cultivar Trial at Azul, Argentina","resumen":"An important aspect for the optimization of productivity and diffusion of asparagus in Argentina is a judicious choice of which  hybrid to sow. The aim of this paper is to evaluate the productivity of thirteen green asparagus hybrids within the framework of the Fourth International Asparagus Cultivar Trial, one year after plantation. A trial with four random blocks was planted on 16\/11\/2011 at the Experimental Field Unit, Faculty of Agronomy, UNCPBA (36°48?South lat. and 59°51?West-long.) with a density of 23,810pl.ha-1, with the following genotypes: of European origin, ?Italo?, ?Vittorio?, ?Eros?, ?Ercole?, ?Giove? and ?Franco?; of Asian origin, ?Chino? and of American origin, ?Early-California?, ?UC- 157? , ?Patrón?, ?NJ- 1189? , ?NJ- 1123? and ?NJ- 1192? , with a total area of 1690m2. Harvesting was performed in the period 10\/09\/2012-01\/10\/2012. The variables studied were: total productivity (PFT) in kg.ha-1; total number of spears (NTT); average weight per spear (PPT) and caliber distribution. Analysis of Variance (ANOVA) and Least Significant Difference (LSD) were applied. On average, the following were obtained, for PFT:931kg.ha-1; for NTT:63932 spears.ha-1, and for PPT:12.7g. For PFT, Patron: 1762(a), NJ-1123: 1346 and UC-157: 1340(b), Early-California:1198(bc), Italo and Vittorio (c) kg.ha-1 stood out from the rest; whereas for NTT, the most productive was Patron: 118980 (a); followed by UC-157: 99240(b); NJ-1123: 810000(c); Early-California: 795000; Vittorio:71280 and Italo:66780(cd) turions. Regarding the distribution of calibers, the only hybrid that produced Jumbo was Franco. For XL, NJ-1123 and Italo (a) stood out, followed by Patron (ab) and Early-California (abc); for Large: Patron (a), NJ-1123(b), Early-California (bc); Italo, Vittorio and UC-157 (bcd); for Medium: Patron and UC-157(a); Early-California (b), Italo and Ercole (bc) and, finally, for Small: UC-157(a), Patron (b), Early-California (c), Ercole (cd) and Italo (bcd). This preliminary evaluation indicates that ?Patron?; ?UC- 157? ; ?Italo?; ?NJ- 1123? and Early-California? would be the most appropriate hybrids for growing green asparagus at Azul, Argentina.","palabras_clave":"PRODUCTIVITY|GENOTYPES|CULTIVATION|PERFORMANCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17295,"idioma_id":4,"titulo":"Status, population trend and genetic structure of South American fur seals Arctocephalus australis in southwestern Atlantic waters","resumen":"The South American fur seal (SAFS), Arctocephalus australis, was severely depletedduring the 18th century. This work updates information on distribution, abundance,seasonal movements, and genetic structure along the southwestern SouthAtlantic. Its distribution in Argentine waters includes nineteen rookeries on the Patagoniancoast, Isla de los Estados, and islets of the Beagle Channel. Censuses werecarried out in rookeries from Isla Escondida to Isla de los Estados from 1996 to2014. The largest concentrations are found in Chubut, (4,500?15,500 seals) and Islade los Estados (4,500). Pups were recorded on Isla Escondida, Rasa, and Isla de losEstados. An increasing number of SAFS were recorded in northern Patagonia,including seals marked in Uruguay. Skin samples were taken from southern Brazilto Tierra del Fuego in order to evaluate population structure and demographictrends. Genetic results indicated no population subdivisions (&#934;st = ?0.0292, Fst =?0.00716, P > 0.05). Bayesian skyline plots constructed for the entire data set indicatedevidence of rapid population expansion discernible in Nef between the last20,000 and 17,000 yr. Genetics results and observation data from marked fur sealssupport the hypothesis of ancient gene flow and a single Atlantic population.","palabras_clave":"South American fur seal|Arctocephalus australis|distribution|abundance|population trend|genetic structure|seasonal movements|Sothwestern South Atlantic"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17296,"idioma_id":4,"titulo":"Morphological and behavioral differences in the gastropod Trophon geversianus associated to distinct environmental conditions, as revealed by a multidisciplinary approach","resumen":"The gastropod Trophon geversianus exhibits shell polymorphisms along its distribution in subtidal and intertidalhabitats. Our hypothesis is thatmorphological and behavioral patterns of T. geversianus represent habitat-specificconstrains; subsequentlywe expect an association between shell morphology, attachment behavior, and habitat.In order to test this hypothesis we compared individuals from intertidal and subtidal habitats, at three sites inGolfo Nuevo (Argentina). We analyzed shell morphology using classic morphometric variables, 3D geometricmorphometrics and computing tomography scan. The results were complemented with field observations ofattachment to substrate and turning time behavior, as well as of the number of shell scars produced by crabpredation. Our results showed differences in shell size and shape between intertidal and subtidal-collectedindividuals. Centroid size, total weight and shell weight, as well as shell density and thickness were significantlylower in intertidal individuals than in subtidal ones. Gastropods from intertidal habitats presented a low-spiredshell and an expanded aperture which might allow better attachment to the bottom substrate, while subtidalindividuals presented a slender and narrower shell shape. The number of crab scars was significantly higher inshells from subtidal individuals. Observations of the behavior of gastropods placed at the intertidal splash zoneshowed 100% of attachment to the bottom in the intertidal individuals, while subtidal specimens only attachedin average in 32% of the cases. These latter took 12 times longer to re-attach to the bottom when faced up.Phylogenetic analysis of COI gene fragments showed no consistent differences among individuals sampled inboth habitats. All these results suggest that T. geversianus has developed two ecomorphs with distinct morphologicaland behavioral responses to physically stressful conditions registered in north Patagonian intertidals, asopposed to lower physical stress but higher predation pressure in the subtidal habitats. The findings of thiswork constitute a starting point in the study of ecological adaptation processes in gastropods from Patagoniancoastal environments.","palabras_clave":"3D Geometric Morphometrics|CT Scan|COI|Rocky Shores"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17297,"idioma_id":4,"titulo":"Effect of recreational diving on Patagonian rocky reefs","resumen":"Tourism has grown considerably in the last decades, promoting activities such as recreational SCUBA diving that may affect marine benthic communities. In Puerto Madryn, Patagonia Argentina, sub-aquatic tourism areas (STA) receive about 7,000 divers per year. Diving is concentrated on a few small rocky reefs and 50% of the dives occur in summer. In this work, we evaluated the effect of recreational diving activities on benthic communities and determined whether diving causes a press (long-term) or a pulse (short-term) response. We quantified the percentage cover of benthic organisms and compared benthic assemblage structure and composition between two sites with contrasting usage by divers, 'highly disturbed' and 'moderately disturbed' sites, and two 'control' sites with similar physical characteristics but no diving activity, twice before and after the diving peak in summer. We found differences in benthic assemblage structure (identity and relative abundance of taxa) and composition (identity only) among diving sites and controls. These differences were consistent before and after the peak of diving in summer, suggesting that recreational diving may produce a press impact on overall benthic assemblage structure and composition in these STA. At the moderately disturbed site, however, covers of specific taxa, such as some key habitat-forming or highly abundant species, usually differed from those in controls only immediately after summer, after which they begun to resemble controls, suggesting a pulse impact. Thus, STA in Golfo Nuevo seem to respond differently to disturbances of diving depending on the usage of the sites. This information is necessary to develop sound management strategies in order to preserve local biodiversity.","palabras_clave":"Rocky reefs|Human impacts|Disturbance|SCUBA diving"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17298,"idioma_id":4,"titulo":"OVIPOSITION AND EMBRYONIC DEVELOPMENT IN THE VOLUTID SNAIL ADELOMELON ANCILLA","resumen":"Intracapsular embryonic development is common in marine gastropods. In many species, embryos obtain nutrition during ontogeny by ingesting substances contained in the intracapsular fluid. South American volutids spawn egg capsules containing relatively few eggs, and development is entirely intracapsular, with young hatching as crawl away juveniles. The spawning habits, egg capsules morphology, and embryonic development of the South American volutid, Adelomelon ancilla is described in this work. Egg capsules of A. ancilla (n= 42) contained 3.0 ± 1.4 (mean ± SD) embryos with a range of 1-6 egg or embryos. The embryonic morphological changes and body spiralization occur simultaneously with embryo feeding. All embryos within a single egg capsule shared the same developmental stage. No evidence of cannibalism or intracapsular competition was found, suggesting that food is not a limiting resource as in other volutid species. Estimated intracapsular developmental time varied between 5 and 6 months (between 12-14° C). The long developmental time and low number of embryos inside the egg capsules, together with late reproductive maturity and longevity of adult individuals reinforce the statement that the neogastropod Adelomelon ancilla is a fragile resource that must be conserved in Argentinean benthic communities.","palabras_clave":"NEOGASTROPODA|VOLUTIDAE|EGG CAPSULES|INTRACAPSULAR DEVELOPMENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17299,"idioma_id":4,"titulo":"NEOTECTONICS AND SEISMICITY IN SOUTHERN PATAGONIA","resumen":"      Research for evaluation of geologic hazards involving earthquakes  and volcanic eruptions in southern  Argentina seems to have historically received little attention.  Nevertheless, the relatively small work done indicates a Neogene tectonic  architecture in the area with capability of generating potential hazardous  earthquakes in a growing population region.      Seismicity and some morphotectonic evidences of  Quaternary activity of the  Magallanes-Fagnano left-lateral fault system in the transform boundary between South America and  Scotia plates, are analyzed  in this paper. This fault system is considered to be an important seismogenic source, responsible for large earthquakes occurred  in southern Argentina. Some  examples from the South and Austral Andean Volcanic Zones are also examined in  order to show recent volcanic activity which also generated crustal seismicity.  Preliminary hazard estimation  clearly shows the presence of both potentially active volcanic centres in southern Patagonia that may also trigger seismicity and the high probability  for large crustal earthquake generation.  ","palabras_clave":"NEOTECTONICS|VOLCANISM|SEISMICITY|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17300,"idioma_id":4,"titulo":"Corrosion behaviour of a SiOxNy coated and nitrided  PH stainless steel","resumen":"Precipitation hardening stainless steels are used in applications where wear and corrosion resistance are required. To improve the surface properties, thermochemical treatments in combination with hard coatings can be used. In this work, the corrosion behavior of SiOxNy coatings deposited on nitrided and non nitrided Corrax® PH stainless steel were evaluated comparing them with the behavior of samples which were only nitrided (two different conditions of nitrogen percentage in the working gases were used). The microstructure was analyzed. Corrosion behavior was evaluated by the Salt Spray Fog Test and cyclic potentiodynamic polarization in NaCl solution. Erosion-corrosion tests were conducted. The thickness of the coating was about 1.4 microns, and its hardness was 2300 HV. The film had better erosion and corrosion behavior when it was deposited on the nitrided steel. This fact demonstrated that the nitrided layer results in a good interface that improves the adhesion and mechanical support.","palabras_clave":"PH STEELS |PACVD|CORROSION|PLASMA NITRIDING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17301,"idioma_id":5,"titulo":"Enriquecimiento forestal en fajas en un bosque explotado del Chaco húmedo","resumen":"En la provincia del Chaco, el bosque nativo cubre aproximadamente cinco millones de hectáreas, pero la sobreexplotación del mismo ha ocasionado que la participación de las especies comercialmente importantes disminuya en forma alarmante. Este trabajo evaluó una técnica de enriquecimiento en fajas con plantas de Grevillea robusta, Handroanthus heptaphyllus y Peltophorum dubium en  un bosque del Chaco húmedo que fue explotado en el siglo pasado hasta la década del treinta y con algunas extracciones leves posteriores. Al momento de establecer el ensayo la masa contaba con 17 m2 de área basal (57 % del área basal del bosque sin aprovechamiento). Se evaluó la sobrevivencia de los individuos plantados, la situación de competencia en la cual se desarrollaban y su crecimiento en diámetro y altura. Los resultados, luego de seis años de la plantación, mostraron que sólo en el caso de Peltophorum dubium se obtuvieron buenos resultados de sobrevivencia y que el crecimiento, tanto en diámetro como en altura fue pobre, ya que las plantas de enriquecimiento crecieron bajo fuerte competencia. Los individuos que encontraron situaciones puntuales de menor competencia marcaron diferencias en crecimiento frente al resto.","palabras_clave":"Enriquecimiento forestal|Recuperación de bosques |Chaco húmedo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17302,"idioma_id":4,"titulo":"Soil Carbon, multiple benefits","resumen":"In March 2013, 40 leading experts from across the world gathered at a workshop, hosted by the European Commission, Directorate General Joint Research Centre, Italy, to discuss the multiple benefits of soil carbon as part of a Rapid Assessment Process (RAP) project commissioned by Scientific Committee on Problems of the Environment (SCOPE). This collaboration led to the publication of the SCOPE Series Volume 71 ?Soil Carbon: Science, Management and Policy for Multiple Benefits?; which brings together the essential scientific evidence and policy opportunities regarding the global importance of soil carbon. This short communication summarises the key messages of the assessment including research and policy implications.","palabras_clave":"ECOSYSTEM SERVICES|RAP WORKSHOP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17303,"idioma_id":4,"titulo":"Physicochemical characterization and stability of chia oil microencapsulated with sodium caseinate and lactose by spray-drying","resumen":"Microencapsulation is an alternative to protect chia oil from the adverse influence of the environment, since this oil is susceptible to oxidation due to their high content of polyunsaturated fatty acids (PUFAs). The aim of this study was to investigate the influence of the operating conditions (homogenization pressure for emulsifying and spray-drying inlet\/outlet temperatures) on the physicochemical properties of chia oil microencapsulated with sodium caseinate and lactose by spray-drying. Oil-in-water emulsions were prepared with 10 %wt\/wt sodium caseinate, 10 %wt\/wt lactose and 10 %wt\/wt chia oil using a high pressure homogenizer at 400 and 600 bar. These emulsions were spray-dried at inlet\/outlet temperatures of 135\/70 °C and 170\/90 °C. The microcapsules were approximately spherical in shape with some small pores and a polydisperse particle size distribution, recording moisture contents of 1.48?3.52 g\/100 g (d.b.). The encapsulation efficiency was N90% in all cases. The particle size distributions of parent and reconstituted emulsions displayed a unimodal distribution. The emulsion reconstituted of microcapsules obtained from emulsions at 400 bar presented a higher initial particle size (D [4,3] = 0.48?0.54 &#956;m; D [3,2] = 0.31?0.33 &#956;m) than those prepared at 600 bar (D [4,3] = 0.33?0.35 &#956;m; D [3,2] = 0.24?0.25 &#956;m). The dispersibility of microcapsules was assessed by measuring the change in droplet obscuration as a function of time. Physical stability of the different reconstituted emulsions was studied by recording the backscattering profiles (BS) as a function of the cell length and time. Regarding oxidative stability during storage, chia bulk oil showed higher peroxide values (PV) than microencapsulated oil during storage. The microcapsules obtained from emulsions at 600 bar showed higher PV than those at 400 bar. The results indicate that the microencapsulation process consisting of emulsification using high-pressure valve homogenizer and subsequent spray-drying is suitable for preparing sodium caseinate-lactose-based microcapsules containing chia oil.","palabras_clave":"Microcapsules|Chia oil|Sodium caseinate|Lactose|Emulsion|Spray-drying"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17304,"idioma_id":4,"titulo":"- Involvement of nitric oxide and caveolins in the age-associated functional and structural changes in a heart under osmotic stress","resumen":"Previous work done in our laboratory showed that water restriction during 24 and 72 h induced changes  in cardiovascular NOS activity without altering NOS protein levels in young and adult animals. These  findings indicate that the involvement of NO in the regulatory mechanisms during dehydration depends  on the magnitude of the water restriction and on age. Our aim was to study whether a controlled water  restriction of 1 month affects cardiac function, NO synthase (NOS) activity and NOS, and cav-1 and -3  protein levels in rats during aging. Male Sprague-Dawley rats aged 2 and 16 months were divided into  2 groups: (CR) control restriction (WR) water restriction. Measurements of arterial blood pressure, heart  rate, oxidative stress, NOS activity and NOS\/cav-1 and -3 protein levels were performed. Cardiac function  was evaluated by echocardiography. The results showed that adult rats have greater ESV, EDV and SV  than young rats with similar SBP. Decreased atria NOS activity was caused by a reduction in NOS protein  levels. Adult animals showed increased cav-1. Water restriction decreased NOS activity in young and  adult rats associated to an increased cav-1. TBARS levels increased in adult animals. Higher ventricular  NOS activity in adulthood would be caused by a reduction in both cav. Water restriction reduced NOS  activity and increased cav in both age groups. In conclusion, our results indicated that dehydration  modifies cardiac NO system activity and its regulatory proteins cav in order to maintain physiological  cardiac function. Functional alterations are induced by the aging process as well as hypovolemic state.","palabras_clave":"Aging|Cardiac morphology|Caveolins|Heart nitric oxide|Water restriction"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17305,"idioma_id":4,"titulo":"PIP1 aquaporins: Intrinsic water channels or PIP2 aquaporin modulators?","resumen":"The highly conserved plant aquaporins, known as Plasma membrane Intrinsic Proteins (PIPs), are the main gateways for cell membrane water exchange. Years of research have described in detail the properties of the PIP2 subfamily. However, characterizing the PIP1 subfamily has been difficult due to the failure to localize to the plasma membrane. In addition, the discovery of the PIP1?PIP2 interaction suggested that PIP1 aquaporins could be regulated by a complex posttranslational mechanism that involves trafficking, heteromerization and fine-tuning of channel activity. This review not only considers the evidence and findings but also discusses the complexity of PIP aquaporins. To establish a new benchmark in PIP regulation, we propose to consider PIP1?PIP2 pairs as functional units for the purpose of future research into their physiological roles.","palabras_clave":"aquaporin|water permeability|heteromerization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17306,"idioma_id":4,"titulo":"Discrimination of Parahydrogen Induced Polarization Signals with J-spectra Acquisition in Poorly Hyperpolarized Samples","resumen":"The application of parahydrogen for the generation of hyperpolarization   has increased continuously during the last years. When the chemical   reaction that deposits the parahydrogen atoms into the target molecule   is carried out following the PASADENA protocol an anti-phase signal is   obtained, with a separation of the resonance lines of only a few Hz.   Signal cancelation can be produced by line broadening due to magnetic   field inhomogeneities or by the superposition with thermal signals. In   this work we show that the acquisition of a J-spectrum has a   double effect of enhancing spectral resolution and separating PHIP from   thermal contributions even in systems where only a very small amount of   hyperpolarization can be achieved.","palabras_clave":"Nuclear Magnetic Resonance|Hyperpolarization|J-Spectra|CPMG"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17309,"idioma_id":5,"titulo":"Las competencias comunicativas en el nivel superior","resumen":"...","palabras_clave":"COMPETENCIAS|NIVEL|SUPERIOR|COMUNICACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17310,"idioma_id":4,"titulo":"Patagonian red wines: PCR-DGGE analysis with two targeted genes revealed the prevalence of Lactobacillus plantarum and Oenococcus oeni during spontaneous malolactic fermentation","resumen":"AbstractBackground and AimsInformation regarding the composition and dynamics of microbial communities throughout winemaking is always valuable to control the process and contributes to improving the quality of wine. The aims of this work were to analyse the diversity of lactic acid bacteria (LAB) species present during the spontaneous malolactic fermentation (MLF) of Patagonian red wines, and to isolate and identify native LAB species.Methods and ResultsSamples of Merlot and Pinot Noir wines were collected during three vintages at one commercial cellar. Through polymerase chain reaction (PCR)-rpoB\/denaturing gradient gel electrophoresis (DGGE), it was possible to identify 15 LAB species and through PCR-16S rRNA V3 region\/DGGE, 11 LAB species, during spontaneous MLF of these wines, mostly, Oenococcus oeni and Lactobacillus plantarum. These two species were also largely recovered by culture and analysed by the random amplified polymorphic DNA?PCR technique. Isolates of these two LAB species exhibited considerable genotypic heterogeneity.ConclusionsThe prevalence of O.&#8201;oeni and Lb.&#8201;plantarum in all samples suggests that both species are involved in leading the spontaneous MLF of these Patagonian wines. The analysis of the LAB microbiota in wine by PCR-DGGE using two gene regions enabled addition to the number of species that can usually be detected during MLF.Significance of the StudyThe study offered a more complete knowledge of the LAB community present in wines in a cellar in the Argentine Patagonia during the spontaneous MLF. Our findings are particularly relevant, because they contribute to the possibility of designing an MLF starter composed of native strains of Lb.&#8201;plantarum and O.&#8201;oeni.","palabras_clave":"Lactobacillus plantarum|malolactic fermentation|Oenococcus oeni|Patagonian red wine|PCR-DGGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17311,"idioma_id":4,"titulo":"The Impact of agriculture on soil texture due to wind erosion","resumen":"Wind erosion produces textural changes on topsoil of semiarid and arid environments,  however the selection of particles on different textured soils is unclear. Our objectives were to: evaluate textural changes induced by wind  erosion on cultivated soils of different granulometry, and to asses if textural changes produced by wind erosion are linked to aggregation of granulometric particles into different sizes of aggregates  formed in contrasting textured soils. Considering this, we studied the particle size  distribution (PSD) with full dispersion (PSDF) of fourteen cultivated (CULT) and  uncultivated (UNCULT) paired soils; and on selected sites the PSD with minimum  dispersion (PSDMIN) and the quotient PSD MIN\/F. Results showed that the content of silt  plus clay was lower in CULT than in UNCULT in most  of the sites. The highest  removal of silt was produced in soils with low sand and high silt content, meanwhile the  highest removal of clay was observed in soils with medium sand content. According to  PSDMIN, particles of 250$2000 µm predominated in the sandy soil, in the loamy soil  particles between 50$250 µm and in the silty loam soil particles between 2$50 µm. For  clay sized particles PSD MIN\/F was lower than 1 in all soils and managements, but this  quotient was higher in CULT compared to UNCULT only in the loamy soil. This means a decrease of clay accumulation in aggregates of larger sizes produced by management which indicates an increase in the risk of removal of these particles by wind in loamy soils.","palabras_clave":"Soil aggregation|wind erosion|semiarid regions"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17312,"idioma_id":5,"titulo":"LA FÍSICA EN LA VIDA COTIDIANA: CURSO NO FORMAL PARA ADULTOS MAYORES","resumen":"        El  incremento de la esperanza de vida de la población debe estar asociado a un  envejecimiento activo y a un rol socialmente significativo: ello implica la  generación de nuevos espacios para su enriquecimiento social y cultural, entre  los que se encuentran los educativos. Desde hace varias décadas se han ofrecido  programas de educación no formal para la tercera edad que dan respuesta a estas  inquietudes culturales, a la organización del ocio y el tiempo libre y a la  ampliación de las relaciones interpersonales. En 2011 se creó en la Universidad  Nacional de Rosario el Programa  Universidad Abierta para Adultos Mayores, que incluye, entre otros, un  curso de física, centrado en aspectos relativos a la física de la vida  cotidiana. En este trabajo se presentan el diseño del curso y los resultados de  una encuesta destinada a conocer si este curso de física es considerado  significativo por los participantes, es decir, cumple con los objetivos de  programas educativos no formales para adultos mayores.  ","palabras_clave":"adultos mayores|educación no formal|curso de física|envejecimiento activo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17313,"idioma_id":4,"titulo":"POROUS TITANIUM DIOXIDE COATINGS OBTAINED BY ANODIC OXIDATION FOR PHOTOCATALYTIC APPLICATIONS","resumen":"The aim of this work is to obtain porous titanium dioxide with good efficiency for photocatalytic environmental applications. TiO2 coatings were obtained by anodic spark deposition, at constant applied potential (150 V), using a platinum cathode and 0.5 M sulfuric acid as electrolyte. Samples of titanium Grade 2 were used as substrate, metallographically prepared until 1 &#956;m diamond surface finishing. The variables of the process were temperature (25 and 40 °C) and anodization time (5 and 10 min). Samples obtained at 40 °C showed a higher current density than those obtained at 25 °C and the potential reached by these samples was lower than those obtained at 25 °C. These results are attributed to an increased electrolyte conductivity. Optical microscopy images of the oxides obtained at 40 ºC showed heterogeneity in color, indicating a non-uniform oxide thickness. Thiscoincides with the images obtained by scanning electron microscopy that revealed 'valleys' where the material did not present porosity. On the other hand, the oxides obtained at 25 °C showed a complete homogeneous porous structure. The average pore diameter was reduced with the increased oxidation time and temperature of the electrolyte. An increase of the crystalline anatase phase was observed with an increase of the anodization time; besides, rutile formation was observed, probably due to the final potential achieved by the samples.","palabras_clave":"Anodic oxidation|Titanium dioxide|Sulfuric acid"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17314,"idioma_id":4,"titulo":"ELECTROCHEMICAL TESTS IN STAINLESS STEEL SURGICAL IMPLANTS","resumen":"In the present work the corrosion resistance of stainless steels was evaluated following the specifications of ASTM F-745standards. The specimens were obtained by two methods, the conventional process of investment casting and countergravity lowpressure casting. Cyclic polarization tests were performed according to ASTM F 2129, using a conventional three-electrode cell,with Pt as a counter electrode and saturated calomel as a reference electrode. The experiments were performed at (37 ± 1) ºC and,before starting the test, the electrolyte was purged with N2 gas for 15 minutes. As electrolyte, a solution of 0.9% NaCl was usedS+§WKHRSHQFLUFXLWSRWHQWLDO2&3ZDVPRQLWRUHGIRUKRXUDQGWKHQWKHSRWHQWLRG\\QDPLFVFDQQLQJVWDUWHGLQWKHDQRGLFdirection, at a speed of 0.167 mV\/s, from a potential of 100 mV below the OCP. The sweep was reversed after passing thethreshold of current density at a value hundred times greater than the current density of pitting. Measurements of electrochemicalimpedance spectroscopy were performed after one hour of exposure of the specimens to OCPs performed in a frequency rangefrom 100 kHz to 1 mHz and potential amplitude of ± 10 mV. The microstructure of the samples was analyzed before and aftertesting using optical microscopy. The results indicated that the samples in general exhibit crack corrosion, and in some cases theoccurrence of pitting corrosion was observed. Also, the capacity values were within the range corresponding to the electricdouble layer and the charge transfer resistance increased on the specimens obtained by conventional casting in ceramic mold.","palabras_clave":"Biomaterials|Corrosion|Stainless steel"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17315,"idioma_id":4,"titulo":"EVALUATION OF CORROSION RESISTANCE OF ALUMINUM-BASED ALLOYS IN BIOETHANOL PRODUCED IN MISIONES","resumen":"Nowadays, biofuels represent a large part of renewable energies destined to substitute fossil fuels, and to reduce the negative impact on the environment. Bioethanol is obtained by alcoholic fermentation, and is used pure or mixed with other petroleum derivatives as fuel. Use, manipulation, storage and transport of these substances, at any scale, demand the implementation of materials, such as aluminum, that has excellent mechanical properties, as well as low density. Generally, these characteristics are improved by alloying aluminum with silicon (in order to decrease the thermal expansion coefficient and increase wear resistance) and magnesium (to increase hardness of the material). Potentiodynamic polarization and electrochemical spectroscopy impedance techniques were used on this research, in order to determine the corrosion resistance of Al-10 wt.%Si, Al-12 wt.%Si, Al-2%Mg and Al-4 wt.%Mg alloys in an alcoholic electrolyte (bioethanol of Misiones province, Argentina industry). Comparing to pure aluminum, aluminum-silicon alloys presented better corrosion resistance. On the other hand, aluminum-magnesium alloys didn?t have such improvement. By using optical metallographic microscope, no differences were found on the surfaces of alloys after being exposed to the alcoholic electrolyte.","palabras_clave":"Biofuels|aluminum alloys|corrosion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17316,"idioma_id":4,"titulo":"READING SOURCES IN ENGLISH TO WRITE a LITERATURE REVIEW IN A ROMANCE LANGUAGE: A GENRE-BASED EAP COURSE IN A MASTERs PROGRAM","resumen":"This article describes a genre-based, field-specific EAP course offered in a Latin American university to Master?s candidates in the area of veterinary science who are in the process of writing the literature reviews of their dissertations. As their dissertations are expected to be novel contributions, the writers need to have access to scientific information in English, although the final product will be produced in their native Romance language, Spanish. To meet this need, we capitalized on the advantages of their context, particularly the common L1 background and the field homogeneity of the course groups, thus allowinged for specific instruction","palabras_clave":"GENRE.BASED PEDAGOGY|READING COURSE|EFL|LITERATURE REVIEW"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17317,"idioma_id":4,"titulo":"The abundance of mixotrophic algae drives the carbon isotope composition of the copepod Boeckella gracilipes in shallow Patagonian lakes","resumen":"      The importance of allochthonous versus  authochthonous carbon to the diet of zooplankters has been discussed at length in  the recent literature and more so in lakes with dissolved organic matter (DOM)  concentrations between 3.5 to 25 mg L-1. Here, we investigated the sources  of carbon of Boeckella gracilipes  (Copepoda, Calanoida) in three Patagonian shallow lakes that have different but  relatively moderate DOM concentrations (&lt;5 mg L-1). We linked  their d13C values with parameters such as  water color (absorbance 440 nm, abs440), dissolved organic carbon  (DOC) concentrations and the ratio Colorabs440:Chlorophyll-a (Chl-a). We also determined the isotopic composition of seston and the  phytoplankton composition. Our results showed a direct relationship between the d13C  values of B. gracilipes and seston (r2=0.64  p&lt;0.001) and we demonstrated the importance of phytoplankton to B. gracilipes as its d13C signal was  strongly related to the abundance of the nanoflagellate Chrysochromulina parva (r2= 0.86 p&lt;0.001). We further found  inverse relationship between DOM and the ratio Colorabs440:Chl-a and B. gracilipes d13C  values (r2=0.67 and 0.56, respectively) which also supported the importance  of authochthonous carbon to the copepod. We conclude that phytoplankton, particularly mixotrophic  algae, rather than allochthonous carbon, supports the copepod B. gracilipes in shallow Patagonian  lakes.   ","palabras_clave":"zooplankton|mixotrophs|carbon stable isotopes|dissolved organic carbon"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17318,"idioma_id":4,"titulo":"Stellar parameters and chemical abundances of 223 evolved stars with and without planets","resumen":"Aims. We present fundamental stellar parameters, chemical abundances and rotational velocities for a sample of 86 evolved stars with planets (56 giants; 30 subgiants), as well as for a control sample of 137 stars (101 giants; 36 subgiants) without planets. The analysis was based on both high signal-to-noise and resolution echelle spectra. The main goals of this work are: i) to investigate chemical differences between evolved stars that host planets and those of the control sample without planets; ii) to explore potential differences between the properties of the planet around giants and subgiants and to search for possible correlations between these properties and the chemical abundances of their host stars. Implications for the scenarios of planet formation and evolution are also discussed. Methods. The fundamental stellar parameters (Teff, log g, [Fe\/H], xi) were computed homogeneously using the FUNDPAR code. The chemical abundances of 14 elements (Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Mn, Co, Ni, Zn and Ba) were obtained using the MOOG code. Rotational velocities were derived from the full width at half maximum (FWHM) of iron isolated lines. Results. The [Fe\/H] distribution of subgiants with planets is centered at metal-rich values and shows an average excess of 0.16 dex compared to the control sample stars. The [Fe\/H] distribution of giants with planets is centered at slightly subsolar metallicities and there is no metallicity enhancement relative to giants without planets. Furthermore, contrary to recent results of Maldonado et al. (2013), we did not find any clear difference between the metallicity distributions of stars with and without planets for giants with Mstar&gt; 1.5 Msun. With regard to the other chemical elements, the analysis of the [X\/Fe] distributions show differences between giants with and without planets for some elements, particularly V, Co and Ba. Subgiants with and without planets show similar behavior for most of the elements. On the other hand, we find no evidence for rapid rotation neither among the giants with planets nor among the giants without planets. Finally, analyzing the planet properties, some interesting trends might be emerging: i) multi-planet systems around evolved stars show a slight metallicity enhancement compared with single-planet systems; ii) planets with a &lt; 0.5 AU orbit subgiants with [Fe\/H] &gt; 0 and giants hosting planets with a &lt; 1 AU have [Fe\/H] &lt; 0; iii) higher-mass planets tend to orbit more metal-poor giants with Mstar &lt;  1.5 Msun, whereas planets around subgiants seem to follow the planet-mass metallicity trend observed on dwarf hosts; iv) [X\/Fe] ratios for Na, Si and Al seem to increase with the mass of planets around giants; v) planets orbiting giants show lower orbital eccentricities than those orbiting subgiants and dwarfs, suggesting a more efficient tidal circularization or the result of the engulfment of close-in planets with larger eccentricities.","palabras_clave":"STARS: ABUNDANCES|STARS: FUNDAMENTAL PARAMETERS|STARS: PLANETARY SYSTEMS|TECHNIQUES: SPECTROSCOPIC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17319,"idioma_id":4,"titulo":"Leptin promotes HLA-G expression on placental trophoblasts via the MEK\/Erk and PI3K signaling pathways","resumen":"INTRODUCTION:The development of the human haemochorial placenta requires complex regulatory mechanisms to protect invasive trophoblast cells from cytotoxic responses elicited by maternal immune cells. Leptin, the adipocyte derived hormone encoded by the Lep gene, is synthesized by placental trophoblasts and exerts pleiotropic effects on the immune system, including the promotion of inflammation and the activation of T cell responses.METHODS:To address its possible involvement in the modulation of maternal immune responses during pregnancy, we investigated the effect of leptin on the expression of the class Ib histocompatibility antigen HLA-G as one of the chief immunosuppressive strategies used by trophoblast cells.RESULTS:In vitro incubation of the trophoblast derived Swan 71 and JEG-3 cell lines with 25-50 ng\/ml recombinant leptin significantly boosted HLA-G mRNA and protein expression, and this effect was abrogated upon pharmacological inhibition of the PI3K-Akt and MEK-Erk signaling pathways. A similar stimulatory effect of leptin was observed in term placental tissue explants, though 10-fold higher doses were required for stimulation. Further, JEG-3 cells treated with a leptin antisense oligodeoxynucleotide displayed decreased HLA-G expression levels, which were partially recovered by addition of stimulating doses of exogenous hormone. Immunofluorescence and qPCR analysis confirmed leptin biosynthesis in placental tissue, further showing that invasive extravillous trophoblast cells were a main source of this hormone during the first trimester of normal pregnancies.DISCUSSION:Taken together, our results show that leptin acts as an autocrine\/paracrine signal promoting HLA-G expression in placental trophoblasts suggesting an important role in the regulation of immune evasion mechanisms at the fetal maternal interface.","palabras_clave":"HLA-G|LEPTIN|PLACENTA|SIGNAL TRANSDUCTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17320,"idioma_id":4,"titulo":"The transcriptional regulator BBX24 impairs DELLA activity to promote shade avoidance in Arabidopsis thaliana","resumen":"In response to canopy shade, plant vegetative structures elongate to gain access to light. However, the mechanism that allows a plastic transcriptional response to canopy shade light is not fully elucidated. Here we propose that the activity of PIF4, a key transcription factor in the shade signalling network, is modulated by the interplay between the BBX24 transcriptional regulator and DELLA proteins, which are negative regulators of the gibberellin (GA) signalling pathway. We show that GA-related targets are enriched among genes responsive to BBX24 under shade and that the shade-response defect in bbx24 mutants is rescued by a GA treatment that promotes DELLA degradation. BBX24 physically interacts with DELLA proteins and alleviates DELLA-mediated repression of PIF4 activity. The proposed molecular mechanism provides reversible regulation of the activity of a key transcription factor that may prove especially relevant under fluctuating light conditions.","palabras_clave":"Shade avoidance|B-Box proteins|DELLA|Arabidopsis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17321,"idioma_id":4,"titulo":"Breaking bonds with electrons: stepwise and concerted reductive cleavage of C-S, C-Se and Se-\tCN bonds in phenacyl thiocyanates and phenacyl selenocyanates","resumen":"The mechanistic aspects of theelectrochemical reduction of phenacyl thio- and selenocyanates have beenstudied. With phenacyl thiocyanates (1),a change in the reductive cleavage mechanism is observed as a function of thesubstituent on the phenyl ring. While a stepwise mechanism involving theintermediacy of a radical anion is followed for substrates bearing a strongelectron withdrawing group such as cyano and nitro substituent (1d, 1e), a concerted mechanism is favoured for compounds bearing anelectron-donating or no substituent on the phenyl ring (1a-c). A regioselectivebond cleavage leads to fragmentation of the CH2-S bond with allcompounds 1a-e, further yielding the corresponding 1,4-diketone (3) as products. Contrastingly, withphenacyl selenocyanates (2), twodifferent reductive cleavages occur involving breaking of both the CH2-Seand Se-CN bonds. Several products are obtained, all coming from nucleophilicattack at the &#945; (phenacyl) carbon or the selenium atom.","palabras_clave":"SELENIUM|SULFUR|ELECTRON TRANSFER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17322,"idioma_id":4,"titulo":"Photochemistry of N-(selenoalkyl)-phthalimides. Formation of N, Se-heterocyclic systems","resumen":"A variety of N-(selenomethyl)alkyl-phthalimides (alkyl = ?(CH2)n?; n = 2?5, 1a, b, d, e) and N-(selenobenzyl) propyl phthalimide (1c) were synthesized and their photochemistry was studied at &#955; = 300 nm.  Steady-state photolysis and laser time-resolved spectroscopy studies confirmed that these reactions proceeded by direct or acetone-sensitized excitation followed by intramolecular electron transfer (ET) between the phthalimide moiety and the Se atom. Two main pathways are possible after ET: proton transfer to the ketyl radical anion from the CH3Se+? or the ?CH2Se+?? moieties, yielding the corresponding biradicals. Collapse of these biradicals yields cyclization products with the respective endo or exo selenium-containing heterocycles. Competition between both proton transfer processes depends on the chain length of the alkyl spacer between the phthalimide and Se groups as well as the size of the cycle being formed.","palabras_clave":"FOTOQUIMICA|SELENIO|CICLIZACION|FTALIMIDAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17323,"idioma_id":4,"titulo":"Do animal-plant interactions influence the spatial distribution of Aristotelia chilensis shrubs in temperate forests of southern South America?","resumen":"Abstract Seed dispersal constrains the environmental heterogeneity to which a plant species is exposed through its life. Behavior of seed dispersers and seed predators could be influenced by food availability and vegetation cover. Consequently, recruitment probabilities are heterogeneous in space and time, and 'regeneration windows' may appear. Aristotelia chilensis is the most abundant fleshy-fruited shrub in the temperate forest of southern South America (TFSA). TFSA exhibits an environmental patchiness that could influence fruit abundance and animal behavior. Our objective was to determine the regeneration windows of A. chilensis, and to detect how forest structure and animal behavior could affect the spatial distribution of this species. We characterized forest structure in two plots that included mature forest, young forest, and open areas. We assessed the spatio-temporal distribution of A. chilensis fruits and studied fruit removal by animals.Also, we experimentally evaluated germination and post-dispersal seed predation. We developed a conceptual model to relate A. chilensis recruitment with forest successional stages. The fruiting individuals of this shrub were mostly located in fire-opened areas or forest gaps, and the seed rain generated by the migratory bird Elaenia albiceps was denser in these areas. In contrast, seed predation by rodents was higher in closed, young forest areas. A. chilensis recruitment follows a nucleation dynamic around fruiting females. Concerningforest succession, A. chilensis recruitment was higher near re-sprouting females in open areas, and lowest in young forests, where fruiting process was hindered by light constraints. When forests mature, new nucleation processes start around females surviving in gaps. Weconclude that areas opened by disturbances provide a regeneration window for A. chilensis shrubs.","palabras_clave":"SEED DISPERSAL|BIRDS|ARISTOTELIA CHILENSIS|PATAGONIAN FOREST"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17324,"idioma_id":5,"titulo":"Las ciudades dentro de la ciudad: características sociodemográficas y habitacionales de la Ciudad de Buenos Aires según sus tipos de hábitat","resumen":"El presente trabajo se propone clasificar y caracterizar el territorio de la Ciudad de Buenos Aires a partir de una tipología de hábitats o contextos urbanos, que definen dinámicas sociodemográficas y residenciales diferenciales. Para ello se retoma la propuesta de la geo-demografía mexicana, que combinó espacializaciones clásicas del nivel socioeconómico de la población con una clasificación del territorio según ?tipos de poblamiento?, definidos a partir del período de urbanización y la forma de producción del espacio habitacional. Tomando como fuente de datos relevamientos previos realizados en la Ciudad y datos del Censo Nacional de Población, Hogares y Viviendas 2010, se clasifican las unidades espaciales que componen la Ciudad de Buenos Aires a partir de esta tipología de entornos urbanos y se realiza una breve caracterización de sus principales rasgos, dando cuenta de las heterogeneidades sociodemográficas y habitacionales que atraviesan este espacio urbano.","palabras_clave":"TIPOS DE HÁBITAT|DIFERENCIAS URBANAS|ESTRUCTURA SOCIODEMOGRÁFICA|CARACTERÍSTICAS HABITACIONALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17325,"idioma_id":4,"titulo":"The rhetoric of surveillance in the Archive of the Intelligence Directorate of the Police of the Province of Buenos Aires","resumen":"Abstract: In this paper I address, from an interdisciplinary perspective, the rhetorical dimension of the surveillance exercised by a specific Repressive State Apparatus, the Intelligence Directorate of the Police of the Province of Buenos Aires (DIPBA), Argentina. This agency was created in 1956 and closed in 1998. I analyze documents that were not declassified until 2003, such as the Institution´s Internal Regulations, the Internal Regulations of the Intelligence School and a Handbook of Intelligence and Counterintelligence. I am interested in the relevance of the notion of discourse community in understanding the central role of discourse in shaping this group of spies and their intelligence practices","palabras_clave":"DISCOURSE COMMUNITY|POLICE|SECRET DOCUMENTS|SURVEILLANCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17326,"idioma_id":4,"titulo":"Public memory and the contemporary epideictic genre: Death \tnotices devoted to Jorge R. Videla","resumen":"On May 17, 2013, Jorge Rafael Videla died in prison while serving a life sentence for crimes against humanity. The first president of Argentina?s last military dictatorship, which lasted from 1976 to 1983. Videla used state terrorism, illegal detention and forced disappearances to combat guerrilla groups in Argentina and stamp out all opposition to his military regime. However, from the day after Videla?s death, the conservative Argentine daily La Nación published a series of death notices from May 17 until May 24 containing tributes to the dead man and, in particular, praising his part in the illegal suppression of guerrillas.   In this paper, I show how these notices were involved in the development of the public memory of the last military dictatorship in Argentina in a controversial relationship (Amossy 2011) with the human rights policy implemented by Presidents Néstor Kirchner  and Cristina Fernández de Kirchner  and their version of the political violence that gripped the country during the 1970s.  Building on Casey?s (2004) and Vivian?s (2004, 2010) ideas on the epideictic genre of public memory, I consider obituaries as a contemporary variant of the same oratory genre. In particular, I analyze how the discourses studied here deviate from the conventions of the epideictic genre, which tends to avoid controversy and is based on values or actions that everyone admits (Aristotle, Ret I 9, 1368; Lausberg 1998; Perelman & Olbrechts-Tyteca 1950, 1963; Pernot 2005). Moreover, I emphasize that these funeral notices repeat certain topics that I call the ?rhetorical-argumentative memory of coups? in my research on discourses supporting military coups d?état in Argentina, (Vitale 2009, 2012, forthcoming).","palabras_clave":"death notices |Jorge Videla|epideictic genre|public memory"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17327,"idioma_id":4,"titulo":"Nanoparticle-cored dendrimers: functional hybrid nanocomposites as a new platform for drug delivery systems","resumen":"Nanoparticle-cored dendrimers (NCDs) are now offering themselves as versatile carriersbecause of their colloidal stability, tunable membrane properties and ability to encapsulate orintegrate a broad range of drugs and molecules. This kind of hybrid nanocomposite aims tocombine the advantage of stimuli-responsive dendritic coating, in order to regulate the drug release behaviour under different conditions and improve the biocompatibility and in vivo halftimecirculation of the inorganic nanoparticles. Size, surface chemistry and shape are keynanocarrier properties to evaluate. Here, we have reviewed the most recent advances of NCDsin drug delivery systems, compared their behaviour with non-dendritic stabilized nanoparticlesand highlighted their challenges and promising applications in the future.&nbsp;","palabras_clave":"nanoparticle|dendrimer|drug delivery|nanocarrier"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17328,"idioma_id":4,"titulo":"Development of a FI-HG-ICP-OES solid phase preconcentration system for inorganic selenium speciation in Argentinean beverages","resumen":"A speciation and preconcentration system has been developed to determine inorganic selenium. Selenium was retained by a column filled with polyvinyl chloride (PVC) with lanthanum hydroxide co-precipitation. Speciation was achieved by introducing a preconcentration step prior selective photoreduction. The retention pH was optimized at 10.0. Two multivariate calibrations and a central composite design were employed for optimization. Sample, reagents and acid flow rates` are significant variables affecting the system. Employing HG-ICP-OES as detection, the optimized system reached a detection limit of 0.03 µg\/L, and an enhancement factor of 14875 (25 for preconcentration system, 595 for hydride generation). The system was applied to inorganic selenium speciation in several Argentinean beverages that allow estimate their selenium contribution to diet. In order to verify the accuracy of the method, certified reference materials BCR® 414 Plankton & IRMM-804 Rice Flour were analyzed.","palabras_clave":"Inorganic Selenium Species|Polyvinyl Chloride (PVC)|Multivariate optimization|Argentinean Beverages"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17329,"idioma_id":5,"titulo":"Gestión de la escuela y la educación en Latinoamérica: análisis de la realidad política","resumen":"En el contexto del mundo del trabajo, podemosdecir que la característica principal es la producción de fuerza capitalista quehan tomado la forma de mercancía, por lo que el trabajador es un simple objetode la producción. La escuela juega un modelo de gestión en condiciones deproducción. Este artículo tiene la intención de pensar la escuela como un lugarde tolerancia y de respeto que propicie el desarrollo de una culturademocrática, por lo que su funcionamiento alienta la participación de todos enla toma de decisiones. El trabajo de la escuela en la gestión, la mayor partedel tiempo, pierde el sentido de espacio de intercambio, construcción yrelación social y se asume en las condiciones del mercado y de la producción.","palabras_clave":"Política|Educación|Gestión|Latinoamerica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17330,"idioma_id":4,"titulo":"Experimental demonstration of a noise-tunable delay line with applications to phase synchronization","resumen":"In this paper we propose and demonstrate a discrete circuit capable of generating arbitrary time delays dependent on noise, either added externally or already present in the signal of interest due to a finite signal-to-noise ratio. We then go on to demonstrate an application to phase locking of signals by means of a standard Phase-Locked Loop (PLL) design, where the usual Voltage-Controlled Oscillator (VCO) is replaced by the noise-tunable delay line.","palabras_clave":"PHASE-LOCKED LOOP|DELAY LINE|SYNCHRONIZATION|STOCHASTIC RESONANCE|NOISE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17331,"idioma_id":5,"titulo":"ANÁLISIS DE LA TRANSMITANCIA TERMICA  Y RESISTENCIA AL IMPACTO DE LOS MUROS DE QUINCHA","resumen":"La quincha es una técnica mixta de muros perteneciente a la familia de los entramados. Compuesta de una armazón estructural (madera o bambú) rellena con barro en estado plástico con añadido de fibras vegetales. Se determinó que la transmitancia térmica de un panel de quincha de 0,10 m de espesor, dando como resultado 2,64 W\/m2K y con el agregado de una placa de poliestireno expandido de 5 mm de espesor en el interior el panel, la transmitancia es 2,02 W\/m2K. Estosvalores son comparables al de un muro de ladrillo de 0,20 m de espesor y revocado en ambas caras, cuyo valor es 4,13 W\/m2K. Para la resistencia al impacto, se construyeron paneles en escala 1:1 y se ensayaron al choque blando. Las deformaciones permanentes fue en todos los casos menor de 3,6 mm requerido por la Norma vigente. Esto implica que no sufrió deformaciones apreciables dando seguridad a los cerramientos de una vivienda. Se concluye que su buen comportamiento térmico y estructural, sumado a las características de ser económico y apropiado para la autoconstrucción, lo hacen viable para implementar a escala masiva.","palabras_clave":"quincha|trasmitancia térmica|impacto"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17332,"idioma_id":4,"titulo":"Didanosine-loaded poly(epsilon-caprolactone) microparticles by a coaxial electrohydrodynamic atomization (CEHDA) technique","resumen":"The goal of this study was to investigate the electrohydrodynamic atomization (EHDA) technology to encapsulate the water-soluble antiretroviral didanosine (ddI) within poly(epsilon-caprolactone) (PCL) particles and stabilize it in the gastric medium where it undergoes fast degradation. A preliminary study employing a one-needle setup enabled the adjustment of the critical process parameters. Then, a configuration of two concentric needles named coaxial electrohydrodynamic atomization (CEHDA) led to the formation of ddI-loaded PCL microcapsules. Scanning electron microscopy analysis showed that the microparticles were spherical and with narrow size distribution. Attenuated total reflectance\/Fourier transform infrared spectroscopy confirmed that most of the drug was efficiently encapsulated within the particles, whereas differential scanning calorimetry and X-ray powder diffraction revealed that the drug was preserved mainly in crystalline form. The loading capacity was relatively high (approximately 12% w\/w), and the encapsulation efficiency was approximately 100%. In vitro release assays (PBS pH ¼ 7.4) indicated that ddI was released almost completely within 2 h. Moreover, the delayed release was expected to isolate ddI from the biological fluids during the gastric transit. Finally, pharmacokineticsstudies in rats showed that ddI-loaded particles lead to a statistically significant increase of the oral bioavailability of almost 4 times and a 2-fold prolongation of the half-life with respect to a ddI aqueous solution, supporting the use of CEHDA as a promising reproducible, scalable and cost-viable technology to encapsulate water-soluble drugs within polymeric particles.","palabras_clave":"COAXIAL ELECTROHYDRODYNAMIC ATOMIZATION (CEHDA)|DIDANOSINE|POLY(EPSILON-CAPROLACTONE)|HIV\/AIDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17333,"idioma_id":5,"titulo":"Ideas infantiles sobre la producción de noticias en los medios","resumen":"En este artículo, se analizan las conceptualizaciones de niños de 6to. grado de escuela primaria de la Ciudad de Buenos Aires sobre los procesos de producción y circulación de noticias en los medios. Forma parte de una investigación mayor sobre las ideas infantiles a propósito de la producción noticiosa y la posibilidad de generar situaciones didácticas que promuevan la lectura crítica de los medios. El foco en esta presentación está puesto en los saberes discursivos que se manifiestan en los dibujos producidos y las discusiones registradas entre los niños, así como en describir la línea de progresión de sus conceptualizaciones referidas a la selección y jerarquización de información que opera en la producción de noticias.","palabras_clave":"Medios|Noticias|Lectura|Crítica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17334,"idioma_id":4,"titulo":"Investigating Albendazole Desmotropes by Solid-State NMR Spectroscopy","resumen":"Characterization of the molecular structure and physicochemical solid-state properties of the solids forms of pharmaceutical compounds is a key requirement for successful commercialization as potential active ingredients in drug products. These properties can ultimately have a critical effect on the solubility and bioavailability of the final drug product. Here, the desmotropy of Albendazole forms I and II was investigated at the atomic level.  Ultrafast magic angle spinning (MAS) solid-state nuclear magnetic resonance (NMR) spectroscopy, together with powder X-ray diffraction, thermal analysis and Fourier Transform infrared spectroscopy, were performed on polycrystalline samples of the two solids in order to fully characterize and distinguish the two forms.  High-resolution one-dimensional 1H, 13C and 15N together with two-dimensional 1H\/1H single quantum - single quantum, 1H\/1H single quantum - double quantum, and 1H\/13C chemical shift correlation solid-state NMR experiments under MAS conditions were extensively used to decipher the intramolecular and intermolecular hydrogen bonding interactions present in both solid forms. These experiments enabled the unequivocal identification of the tautomers of each desmotrope. Our results also revealed that both solid forms may be described as dimeric structures, with different intermolecular hydrogen bonds connecting the tautomers in each dimer.","palabras_clave":"ALBENDAZOLE|DESMOTROPY|TAUTOMERISM|SOLID-STATE NMR|CHARACTERIZATION|ULTRAFAST MAS|RFDR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17335,"idioma_id":4,"titulo":"Pyrosequencing reveals changes in soil bacterial communities after conversion of Yungas forests to agriculture","resumen":"The Southern Andean Yungas in Northwest Argentina constitute one of the main  biodiversity hotspots in the world. Considerable changes in land use have taken place in this ecoregion, predominantly related to forest conversion to croplands, inducing losses in above-ground biodiversity and with potential impact on soil microbial communities. In this study, we used high-throughput pyrosequencing of the 16S ribosomal RNA gene to assess whether land-use change and time under agriculture affect the composition and diversity of soil bacterial communities. We selected two areas dedicated to sugarcane and soybean production, comprising both short- and long-term agricultural sites, and using the adjacent native forest soils as a reference.  Land use change altered the composition of bacterial communities, with differences between productive areas despite the similarities between both forests. At the phylum level, only Verrucomicrobia and Firmicutes changed in abundance after deforestation for sugarcane and soybean cropping, respectively. In cultivated soils, Verrucomicrobia decreased sharply (~80%) while Firmicutes were more abundant. Despite the fact that local diversity was increased in sugarcane systems and was not altered by soybean cropping, phylogenetic beta diversity declined along both chronosequences, evidencing a homogenization of soil bacterial communities over time. In spite of the detected alteration in composition and diversity, we found a core microbiome resistant to the disturbances caused by the conversion of forests to cultivated lands, and few or  none exclusive OTUs for each land-use type. The overall changes in the relative  abundance of copiotrophic and oligotrophic taxa may have an impact in soil ecosystem functionality. However, communities with many taxa in common may also share many functional attributes, allowing to maintain at least some soil ecosystem services after forest conversion to croplands.","palabras_clave":"SOIL MICROBIAL ECOLOGY|FOREST CONVERSION TO AGRICULTURE|SUGAR CANE MONOCULTURE|SOYBEAN MONOCULTURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17336,"idioma_id":4,"titulo":"Effect of actinobacteria on Lotus tenuis - Mesorhizobium loti symbiosis: preliminary study","resumen":"        The  effect of the actinobacteria on the legume Lotus tenuis, a model forage  plant of the Flooding Pampa region in Argentina was to promote plant growth and  root nodulation. L. tenuis seedlings were inoculated either with the  symbiotic N2-fixing strain Mesorhizobium loti, or with  saprophytic strain of Streptomyces MM40, Actinoplanes ME3, or Micromonospora  MM18, or co-inoculated with a combination of one, two or three of them,  together with the rhizobium. The plants were grown in pouches and fertilized with  three nitrogen levels (low, medium and high). L. tenuis plants  co-inoculated with the symbiotic M. loti and actinobacteria showed an  increase in plant biomass and nodulation. Plants fertilized with high N levels  (inhibitory for nodulation by M. loti) were nodulated if the M. loti  strain was added simultaneously with actinobacteria. These preliminary results  show that actinobacteria have potential agronomic application which should be  further explored.  ","palabras_clave":"ACTINOBACTERIA|LOTUS TENUIS|PLANT GROWTH|NODULATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17337,"idioma_id":4,"titulo":"COMPUTER-BASED GLOBAL MODELS:  FROM EARLY EXPERIENCES TO COMPLEX SYSTEMS","resumen":"During the 1960s but mainly in the 1970s, large mathematical dynamic global models were implemented in computers to simulate the entire world, or large portions of it.  Several different but interrelated subjects were considered simultaneously, and their variables evolved over time in an attempt to forecast the future, considering decades as time horizons. Global models continued to be developed while evidencing an increasing bias towards environmental aspects, or at least the public impact of models with such a focus became prevalent.  In this paper we analyze the early evolution of computer-based global modeling and provide insights on less known pioneering works by South American modelers in the 1960s (Varsavsky and collaborators). We revisit relevant methodological aspects and discuss how they influenced different modeling endeavors. Finally, we overview how distinctive systemic approaches in global modeling evolved into the currently well-established discipline of complex systems.","palabras_clave":"Global models|Social processes|Complex systems|History of science"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17338,"idioma_id":4,"titulo":"Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-b-cyclodextrin enhances its activity against a hepatitis C virus surrogate model","resumen":"(1)THESE TWO OUTHORS CONTRIBUTED EQUALLY TO THIS WORK  The current standard of care of the infection by hepatitis C virus (HCV) is effective in a limited number  of patients and the high cost hinders therapy affordability and compliance. In this context, the  research of new direct-acting antiviral agents (DAAs) for a more effective and long-lasting therapy  is an urgent need and an area of active investigation. In an effort to develop novel DAAs, a series of  1-indanone thiosemicarbazones (TSCs) was synthesized and fully characterized. However, the high  self-aggregation tendency and extremely poor aqueous solubility of these antiviral candidates often  preclude their reliable biological evaluation in vitro. To maintain constant TSC concentrations over  the biological assays, different TSC\/cyclodextrin complexes were produced. In the present work, we  report for the first time the cytotoxicity and antiviral activity of 5,6-dimethoxy TSC inclusion complexes  with hydroxypropyl--cyclodextrin on bovine viral diarrhea virus (BVDV) as HCV surrogate  model. Results showed a potent suppression of the virus replication, with greater activity for the  inclusion complexes than the free compound.","palabras_clave":"BVDV|HCV l|THIOSEMICARBAZONES| HYDROXYPROPYL-B-CYCLODEXTRIN|ANTIVIRAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17339,"idioma_id":4,"titulo":"Synthetic hydroxiapatites doped with Zn(II) studied by X-ray diffraction, infrared, Raman and thermal analysis","resumen":"The effect of Zn(II) on calcium hydroxyapatite (CaHap) formation when different amounts of Zn(II) are present in the mother liquor has been investigated by atomic absorption, infrared and Raman spectroscopies, X-ray diffraction and thermal analysis (DTA and TG). The studied samples have been synthesized at T = 95 ºC and pH 9 in air. The analysis of the results showed that the pure CaHap sample crystallizes in the monoclinic form P21\/b. Concentrations up to 20% of Zn(II) in the mother liquor, equivalent to smaller concentrations in solid (up to 9.1 % in wt), favor the formation of the hexagonal apatite, P63\/m, while Zn(II) concentrations higher than 20% in solution help an amorphous phase development where vibrational spectra indicated coexistence of two phases: an apatite and ZnNH4PO4.H 2O. Infrared data of thermal treated samples endorse that HPO42? ion had not been incorporated in Zn(II) doped samples during the synthesis process. Present results also allow to conclude that Zn(II) cation exhibits a preference to occupy the Ca2 site of the apatite structure and induce water adsorption and an small quantity of CO32- cation incorporation. These inclusions generate a less crystalline Ca deficient apatite.","palabras_clave":"Hydroxyapatite cationic substitution|Infrared and Raman spectroscopy|Second derivative spectra|Rietveld analysis|Thermal treatment"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17340,"idioma_id":4,"titulo":"Corrosion protection of carbon steel by silica-based hybrid coatings containing cerium salts: effect of silica nanoparticle content","resumen":"One strategy for minimizing corrosive attack on carbon steel involves the application of hybrid coatings rich in rare earths, on the basis of their low toxicity and environmental sustainability. Tetraethoxysilane (TEOS) and 3-glycidoxypropyl-trimethoxysilane (GPTMS) were each used here as precursors, together with various quantities of colloidal silica suspension, to improve barrier properties of the coatings. Ce(NO3)3·6H2O was added as a source of Ce(III) for further inhibition of corrosion. The corrosion resistance of each kind of sample was evaluated using potentiodynamic polarization measurements and electrochemical impedance spectroscopy (EIS) in 0.35 wt.% NaCl solution. The electrochemical behaviour at various immersion times was modelled by equivalent circuits to demonstrate the effect of silica nanoparticle loading on corrosion. Additional testing was performed under harsh conditions of salt spray chamber. The microstructure and composition of sol-gel coatings were characterized by scanning electron microscopy and energy dispersive X-ray spectroscopy (SEM\/EDS), focused-ion beam SEM\/EDS analysis, X-ray photoelectron spectroscopy and confocal microscopy.","palabras_clave":"CARBON STEEL|HYBRID COATING|SILICA NANOPARTICLES|CERIUM|CORROSION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17341,"idioma_id":4,"titulo":"Carbon supported Pt-NiO nanoparticles for ethanol electro-oxidation in acid media","resumen":"In the present work, the influence of nickel oxide as a co-catalyst of Pt nanoparticles for the electro-oxidation of ethanol in the temperature range of 23-60°C was investigated. The carbon supported nickel oxide and platinum nanoparticles were prepared by hydrothermal synthesis and microwave-assisted polyol process respectively, and characterized by XRD, EDX, TEM and ICP analysis. The electrocatalytic activity of the as-prepared materials was studied by cyclic voltammetry and chronoamperometry. Small metal nanoparticles with sizes in the range of 3.5-4.5 nm were obtained. The nickel content in the as-prepared Pt-NiO\/C catalysts was between 19 and 35 at.%. The electrochemical experiments showed that the electrocatalytic activity of the Pt-NiO\/C materials increase with NiO content in the entire temperature range. The apparent activation energy (Ea,app) for the overall ethanol oxidation reaction was found to decrease with NiO content (24-32 kJ mol-1 at 0.3 V), while for Pt\/C the activation energy exceeds 48 kJ mol-1. The better performance of the Pt-NiO\/C catalysts compared to Pt\/C sample is ascribed to the activation of both the C-H and O-H bonds via oxygen-containing species adsorbed on NiO molecules and the modification of the surface electronic structure (changes in the density of states near the Fermi level).","palabras_clave":"Pt-NiO\/C nanostructured catalysts|ethanol oxidation|temperature dependence|apparent activation energy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17342,"idioma_id":4,"titulo":"Effect of ceria on the organization and bio-ability of anatase fullerene-like crystals","resumen":"The nanostructure and the oxygen storage capacity against reactive oxygen species (ROS) are essential features to take into account during the design of a new material that will be used as the basis of novel therapeutic technologies. Here we evaluate the incorporation of nano-ceria, which has a demonstrated ability to scavenge free radicals under physiological conditions comparable to those observed for superoxide dismutase and catalase, to TiO2 crystalline assemblies. The material was planned to merge the scavenging properties of CeO2 on a specifically designed structured TiO2 substrate. The presence of Ce atoms has a clear influence on the materials´ morphologies, distorting the anatase crystal lattice and inducing the formation of fullerene-like structures. The cytotoxicity of the materials against L929 fibroblasts after 24 hours of cell culture was evaluated. Both structural and oxidative properties of the materials have a clear effect on fibroblast viability; in fact it was demonstrated that cellular proliferation can be modulated by varying the Ce3+\/Ti4+ molar ratio.","palabras_clave":"NANOCERIA|TITANIUM-DIOXIDE|FULLERENE-LIKE|ANTIOXIDANT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17343,"idioma_id":4,"titulo":"Nano-hydroxyapatite for use in bone tissue repair","resumen":"Bone can be considered as a biological hybrid material composed of organic and inorganic components: collagen and rod-shaped hydroxyapatite (HAP) of 20?50 nm lengths. The synthetic hydroxyapatite (Ca10(PO4)6(OH)2) has been extensively used as a bone substitute material due to its chemical and structural similarities with natural mineral bone. One way to obtain HAP nanoparticles is by using self-assembled amphiphilic molecules as structure directors. This study involves different hexadecyltrimethylammonium bromide (CTAB) micellar-block copolymer organized networks. Inorganic precursors were added in sequence to the CTAB-polymer solution, followed by a hydrothermal treatment. The final product was separated from the suspension by filtration and then dried. The X-ray diffraction and infrared spectroscopy pattern of the materials synthesized corresponds to the HAP pattern. Transmission and scanning electron microscopy microphotographs show a fiber network composed by 37 nm length HAP nanorods. After treatment with simulated body fluid (SBF) a layer of HAP nanocrystals grew on the material surface; that is related to the bioactivity of the material. To confirm the samples' biocompatibility, calvarial osteoblasts obtained from neonatal rats were exposed to the material and then, viability and cell adhesion were evaluated. A new method of HAP nanocrystals with similar shape, morphology and chemical characteristics of bone were developed. After SBF immersion, material revealed a spherulitic-like HAP layer that implies a positive physiological response and good bond ability to the host tissue. Therefore, nanomaterials obtained by the proposed synthesis could have a wide range of biomedical applications.","palabras_clave":"HYDROXYAPATITE|BONE TISSUE|IMPLANTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17344,"idioma_id":4,"titulo":"Electrochemical Preparation and Characterization of Polypyrrole\/ Stainless Steel Electrodes Decorated with Gold Nanoparticles","resumen":"The electrosynthesis and characterization of polypyrrole (PPy)\/stainless steel electrodes decorated with gold nanoparticles and the performance of the composite electrode for sensing applications is described. PPy films were grown in potassium perchlorate and sodium salicylate solutions under comparable electropolymerization conditions. Polymer films prepared in the presence of perchlorate ions exhibited wormlike structures, whereas columnar structures were obtained in salicylate-containing solutions. Voltammetric response of PPy films prepared in salicylate solutions was more reversible. PPy films were decorated with gold nanoparticles obtained by a double step potentiostatic electrodeposition routine that allowed fine control of deposit characteristics. Analysis of deposits was performed by means of SEM and confocal Raman spectroscopy. The electrocatalytic activity of the Au\/PPy electrodes was assessed for the electro-oxidation of hydrazine and hydroxylamine. Results showed a successful optimization of the route of synthesis that rendered nanocomposite electrode materials with promising applications in electrochemical sensing.","palabras_clave":"GOLD NANOPARTICLES|POLYPYRROLE|STAINLESS STEEL|ELECTRODEPOSITION|HYDRAZINE|HYDROXYLAMINE|SENSORS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17345,"idioma_id":4,"titulo":"Characterization of Two Temperate Lactobacillus paracasei Bacteriophages: Morphology, Kinetics and Adsorption","resumen":"Background\/Aims: Adsorption and kinetic parameters, latent period, burst size and burst time, are characteristics of phage\/host systems and can be affected by several environmental factors. As only few studies have focused on temperate dairy phages, we characterized these parameters ontemperate Lactobacillus paracasei phages i Lp 84 and i Lp 1308, infective for probiotic strains. Methods: Phages were characterized by transmission electron microscopy and genomic DNA restriction. Adsorption under different environmental conditions, phage kinetics and efficiency ofplating (EOP) were determined using the double-layer titration method. Results: Phages i Lp 84 and i Lp 1308 belong to the Siphoviridae family and have genome sizes of 38 and 34 kbp, respectively. Adsorption was affected by calcium concentration, pH, temperature and host viability, and reached a limit at very high multiplicity of infection. Latency, burst time and burst size were of 85 min, 131 min and 46 for i Lp 84, and 51 min, 92 min and 28 for i Lp 1308, respectively, at 37 ° C. A clear influence of temperature on phage kinetics was observed. Regarding EOP, &#934; i Lp 84 produced plaques on only 1 out of 8 strains tested. Conclusion: Noticeable differences in adsorption, kinetics and EOP were found for two morphologically identical temperate L. paracasei phages of similar origin.","palabras_clave":"LACTOBACILLUS|BACTERIOPHAGES|PHAGE ADSORPTION|PHAGE KINETICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17346,"idioma_id":4,"titulo":"Viscoelastic response of linear defects trapped in polymer networks","resumen":"We analyze the dynamic response of end-linked poly(dimethylsiloxane) networks containingentangled unattached guest linear polymers. Upon increasing the content of unattachedguest polymers there is an increasing dissipation and a reduction in the networkelasticity. It was found that the width of the relaxation spectrum is nearly insensitive tothe content of guest chains, indicating that the network structure is not affected by thepresence of these defects and that the effective number of entanglements associated toguest chains is independent of the equilibrium elastic modulus of the networks.The inhibition of the constraints release mechanism for molecules trapped in polymernetworks have enormous consequences on the dynamic response, producing a dramaticslowing down in the relaxational dynamics of defects. The presence of different structuresof defects in polymer networks is physically unavoidable, even under optimum reactionconditions. Here we found that the slow dynamics of soluble branched structures or danglingmolecules can easily hide the contribution of linear unattached molecules.","palabras_clave":"MODEL NETWORKS|VISCOELASTIC PROPERTIES|NETWORK DEFECTS|RUBBER ELASTICITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17347,"idioma_id":4,"titulo":"Benders decomposition applied to security constrained unit commitment: Initialization of the algorithm","resumen":"Benders decomposition has been broadly used for security constrained unit commitment problems, despite the fact that it may present convergence difficulties due to instabilities and to the mixed integer nature of the unit commitment problem. The initialization of Benders decomposition has been recognized as a prominent feature for the algorithm enhancement. In this work, a new Benders decomposition initialization methodology is proposed. The objective of the initialization is to include inexpensive network signals that can be added during the initial unit commitment master problem. Numerical simulations using the IEEE-118 and RTS-96 systems are performed to illustrate the benefits of the proposed initialization methodology. Results suggest that the initialization of Benders decomposition applied to security constrained unit commitment problems improves the overall convergence of the algorithm.","palabras_clave":"Benders Decomposition|Mixed Integer Linear Programming|Security Constrained Unit Commitment"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17348,"idioma_id":4,"titulo":"DUAL-SPECIES RELATIONS BETWEEN Candida tropicalis ISOLATED FROM APPLE JUICE ULTRAFILTRATION MEMBRANES, WITH Escherichia coli O157:H7 AND Salmonella sp.","resumen":"Aims: The objective of this study was to determine the interactions between  common spoilage yeast, Candida tropicalis, isolated from ultrafiltration  membranes, and Escherichia coli O157:H7 and Salmonella sp. on stainless steel  surfaces.  Methods and Results: Single and dual-species attachment assays were  performed on stainless steel at 25°C using apple juice as culture medium. The  growth of Salmonella sp. rose when it was co-cultivated with C. tropicalis in  dual biofilms at 16 and 24 h; the same effect was observed for E. coli O157:H7  at 24 h. The colonization of C. tropicalis on stainless steel surfaces was reduced when it was co-cultivated with both pathogenic bacteria, reducing C. tropicalis population by at least 10 log unit. Visualization by SEM demonstrated that E. coli O157:H7 and Salmonella sp. adhere closely to hyphal elements using  anchorage structures to attach to the surface and other cells.  Conclusions: These results suggest a route for potential increased survival of  pathogens in juice processing environments. These support the notion that the  species involved interact in mixed yeast?bacteria communities favouring the  development of bacteria over yeast.  Significance and Impact of the Study: This study support the plausibility that  pathogen interactions with strong biofilm forming members of spoilage  microbiota, such as C. tropicalis, might play an important role for the survival  and dissemination of E. coli O157:H7 and Salmonella sp. in food-processing  environments.","palabras_clave":"APPLE JUICE|CANDIDA TROPICALIS|ESCHERICHIA COLI O157:H7|SALMONELLA SP.|STAINLESS STEEL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17349,"idioma_id":4,"titulo":"Application of amaranth protein isolate and hydrolysate on a reduced salt fish restructured product: antioxidant properties, textural and microbiological effects","resumen":"This work evaluates amaranth protein ingredients (isolate (I) and alcalase-hydrolysate (H)) acting as antioxidants and binders in restructured fish products. Gel products were obtained after thermal treatment (40 °C, 30 min; 90 °C, 30 min) of different formulations from fish muscle pastes, where salt (2 %) was partially or totally replaced by I or H. Antioxidant activity was assessed by conjugated dienes and thiobarbituric acid reactive substances (TBARs) measurements during the chilled storage. Textural properties, water holding capacity, colour and microbiological quality were evaluated. Reduced-salt content products containing 2 % w\/w of I or H partially inhibited lipid oxidation especially at the level of the decomposition of hydroperoxides into secondary products, due to about 50 and 60 % of inhibition of TBARs, respectively, was registered. Also, these products showed acceptable microbiological quality and technological characteristics with only minimal changes in properties as gel hardness and colour parameters compared with control products (2 % w\/w salt).","palabras_clave":"Amaranth protein isolate|amaranth protein alcalase-hydrolysate|antioxidant activity|binding capacity|restructured fish products|salt content"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17350,"idioma_id":4,"titulo":"Redescription and reevaluation of the taxonomical status of Microsuchus schilleri (Crocodyliformes: Mesoeucrocodylia) from the Upper Cretaceous of Neuqu\u0001en, Argentina","resumen":"Fragmentary remains of Microsuchus schilleri (Crocodyliformes: Mesoeucrocodylia) from the Bajo de La Carpa Formation (Santonian, Late Creteceous) of northern Patagonia, Argentina, are decribed and reevaluated taxonomically. The type specimen is an articulated individual with hindlimb and axial remains. Microsuchus has several traits that allow to recognize it as a valid taxon (the presence of bulge lateral to the prezygapophyses of the second sacral vertebra; elongated posterior zeugopodia; proximal caudal centra with triangular cross section). Microsuchus was originally assigned as a goniopholidid based on the platycely of its vertebral centra, a character that is widely distributed among fossil crocodyliforms. A phylogenetical analysis using an expanded data matrix focusing on postcranial data was performed in which Microsuchus and another long-limbed crocodyliform from the same location, Neuquensuchus, were included. Microsuchus is depicted in a politomy as a basal mesoeucrocodylian, with its position as a  neosuchian or notosuchian supported by a single synapomorphy on the different most parsimonious trees. Additionaly, Neuquensuchus is well nested among notosuchians, in contrast to previous hypothesis. These findings further increase the crocodyliform diversity of the Bajo de la Carpa Formation and emphasize the relevance of its fauna in studies of the diversification of mesoeucrocodylians and notosuchians. Furthermore, the occurrence of both Microsuchus and Neuquensuchus gives evidence of a basal stock of mesoeucrocodylians with elongated limbs that was not previously reported for northern Patagonia.","palabras_clave":"CROCODYLIFORMES|MESOEUCROCODYLIA|UPPER CRETACEOUS|NEUQUÉN BASIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17351,"idioma_id":4,"titulo":"European drought climatologies and trends based on a multi-indicator approach","resumen":"Drought is one of the most important weather-induced phenomena which may have severe impacts on different areas such as agriculture, economy, energy production, and society. From a meteorological point of view, drought can be induced and\/or reinforced by lack of precipitation, hot temperatures and enhanced evapotranspiration. Starting from a multi-indicator approach, we present European-wide meteorological drought climatologies and trends for the period 1950-2012. As input data, we used precipitation and temperature data from the E-OBS (spatial resolution: 0.25 &#778;x0.25 &#778;) gridded dataset of the European Climate Assessment and Dataset (ECA&D). Precipitation, temperature, and the derived potential evapotranspiration (PET) have been used to compute three drought indicators: the Standardized Precipitation Index (SPI), the Standardized Precipitation Evapotranspiration Index (SPEI), and the Reconnaissance Drought Index (RDI). SPI, SPEI, and RDI, calculated for 12-month accumulation period, have been rationally merged into a combined indicator and this quantity has been used to obtain drought frequency, duration, and severity for the entire Europe. We identified the following drought hotspots: Scandinavia, Eastern Europe, and Russia in 1951-1970, no particular hotspot in 1971-1990, the Mediterranean region and the Baltic Republics in 1991-2010. A linear trend analysis shows that drought variables increased in the period 1950-2012 in South-Western Europe, in particular in the Mediterranean and Carpathian regions, with precipitation decrease and PET increase as drivers. Drought variables show a decrease in Scandinavia, Belarus, Ukraine and Russia: precipitation increase is there the main driver. In Central Europe and the Balkans, drought variables show a moderate increase, for the significant PET increase outbalances a not significant precipitation increase.","palabras_clave":"DROUGHT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17352,"idioma_id":4,"titulo":"Inheritance of glyphosate resistance in Lolium perenne and hybrids with Lolium multiflorum","resumen":"Glyphosate-resistant Lolium species have been selected in weed communities where glyphosate is the herbicide used almost exclusively for weed control. The rate of evolution of herbicide resistance is highly  influenced by the mating system and the inheritance type. Given the relevance of Lolium spp. as major weeds of winter cereal crops, it is important to know the basis of how they inherit glyphosate resistance.  During three years of testing, we studied Lolium perenne plants from a glyphosate-resistant population in Argentina. Plants with different glyphosate sensitivity were forced to self-fertilize and breed. In addition, inter-specific hybridizations were obtained using glyphosate-susceptible Lolium multiflorum and glyphosate-resistant L. perenne. Moderately resistant L. perenne plants, when selfed, produced offspring  in three phenotype classes: susceptible, moderately resistant and highly resistant plants in a 1:2:1 ratio,respectively. When moderately glyphosate-resistant plants and susceptible ones were crossed, the  offspring showed the same parental phenotypes in a 1:1 ratio. In crosses between highly resistant plants with susceptible individuals, all offspring showed moderate resistance, while crosses of susceptible  plants produced 100% glyphosate-susceptible individuals. Glyphosate resistance therefore appears to be controlled by a single locus with incomplete dominance and maternal effects are unlikely to play a major  role.  Moreover, glyphosate resistance was inherited in hybrids between susceptible L. multiflorum and resistant L. perenne with a similar type of inheritance pattern as that indicated above. Considering these  cross-pollinated species, glyphosate resistance may be transmitted not only among plants of the same species but also to related species such as L. multiflorum.","palabras_clave":"INHERITANCE|GLYPHOSATE RESISTANCE|INTERSPECIFIC HYBRIDS|LOLIUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17353,"idioma_id":5,"titulo":"VIVIENDA SOCIAL Y ESTRATEGIAS DE SOBREVIVENCIA. SOLUCIONES ADECUADAS A PARTIR DE UN ESTUDIO DE CASO (RESISTENCIA, ARGENTINA, 2013)","resumen":"Las soluciones habitacionales estatales argentinas no dan respuestas adecuadas a las necesidades de los hogares de bajos ingresos que utilizan las viviendas sociales para habitar y para realizar actividades económicas informales de sobrevivencia. Estos hogares trasforman las viviendas provistas por la ayuda social en unidades domésticas de reproducción y de producción de la vida, con consecuentes efectos negativos en la calidad de vida y en las condiciones de habitabilidad de estas viviendas. El siguiente articulo analiza este problema a partir de un estudio de caso localizado en la ciudad de Resistencia (Argentina) desde una perspectiva integral y compleja del hábitat, con la finalidad de extraer aportes que contribuyan con la política habitacional para la resolución adecuada del problema en favor de un hábitat digno.","palabras_clave":"VIVIENDA SOCIAL|ESTRATEGIAS DE SOBREVIVENCIA|SOLUCIONES INTEGRALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17354,"idioma_id":4,"titulo":"Phase Behavior of Model poly(butadiene 1,3)-block-(dimethylsiloxane) copoly-mers","resumen":"Model diblock copolymers of poly(butadiene-1,3) and poly(dimethylsiloxane) (PB-b-PDMS) of different compositions were synthesized by the sequential anionic polymerization (high vacuum techniques) of butadiene 1,3 and hexamethyl(ciclotrisiloxane), (D3), monomers. The block copolymers were characterized by nuclear magnetic resonance (1H and 13C NMR), size-exclusion chromatography (SEC), Fourier  Transform infrared spectroscopy (FTIR), and Small Angle X-ray Scattering (SAXS). SEC combined with 1H NMR analysis indicate that the PB-b-PDMS copolymers exhibit molar masses between 5000 and 13000 g\/  mol, narrow polydispersity index (Mw\/Mn), and chemical compositions ranging from low to intermediate siloxane content. According to SAXS experiments, at room temperature the model block copolymers present morphological arrangements that vary from disordered and body-centered-cubic packing of spheres, to hexagonally packed cylinders and lamellar structures.","palabras_clave":"Anionic polymerization|High vacuum techniques |Model block copolymers"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17355,"idioma_id":4,"titulo":"Non-linear control of a Buck converter which feeds a constant power load","resumen":"In this paper a non-linear control strategy for controlling a dc\/dc Buck converter feeding a constant power load is proposed. The main objective of the proposed controller is to improve the transient performance when in presence of unknown power disturbances. A feedback controller is combined with a feedforward strategy. A non-linear reduced order observer is used for estimating the value of the power load and its time derivative. These estimated values are fed forward to the non-linear feedback controller whose design is based on feedback linearization method. The proposed controller is tested via simulation and experimental results.","palabras_clave":"constant power load|dc\/dc converters|feedforward compensation|power converters"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17356,"idioma_id":4,"titulo":"Food packaging bags based on thermoplastic corn starch reinforced with talc nanoparticles","resumen":"Packaging bags from thermo-compressed films of thermoplastic corn starch containing talc nanoparticles (0, 1, 3 and 5% w\/w) were developed. Mechanical properties of films were studied by two different techniques (tensile tests and quasi-static assays) revealing starch films reinforcement by talc addition. Strength improvement of thermoplastic starch films with talc concentration higher than 3% w\/w was reflected in an increase in both Young´s modulus and yield stress. Talc particles modified failure mode of thermo-seal of thermoplastic starch films giving another bags opening possibility. Usually, bags based on starch films could be only opened by tearing while those of starch-talc bionanocomposites could be torn or peeled off. Finally, in order to evaluate packaging bags tightness, films barrier properties were determined. Water vapor and oxygen permeability were reduced 54 and 26%, respectively, by talc addition (3% w\/w) to thermoplastic starch.","palabras_clave":"bionanocomposite|biodegradable packaging bags|corn starch|talc nanoparticles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17357,"idioma_id":4,"titulo":"Sustainable use of cassava (Manihot esculenta) roots as raw material for biocomposites development","resumen":"This work is focused on the use of cassava roots peel and bagasse as natural fillers of TPS materials based on cassava starch. A deep insight into biocomposites microstructure was performed in order to support mechanical and barrier properties of the final materials. Cassava byproducts chemical composition and particle size distribution helped to explain TPS SEM morphology, mechanical and barrier properties modifications. Processing conditions favored starch-filler interactions leading to lower mixing energy requirements. The matrix-filler compatibility was demonstrated by FTIR and thermal analysis of TPS composites. Filler addition increased UV-barrier capacity and opacity of TPS materials, though water vapor permeability was maintained. Both byproducts reinforce TPS matrices even though low filler concentrations were used. Bagasse addition (1.5%) increased 260% elastic modulus and 128% maximum tensile stress of TPS composites, being the most efficient reinforcing agent due to its high residual starch content and lower proportion of smaller particles.","palabras_clave":"NATURAL FILLERS|CASSAVA ROOT PEEL AND BAGASSE|TPS COMPOSITE PROCESSING|MICROSTRUCTURE CHARACTERIZATION|CASSAVA TPS REINFORCEMENT|COMPRESSION MOULDING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17358,"idioma_id":4,"titulo":"Theoretical study on the molecular structure and vibrational properties, NBO and HOMO-LUMO analysis of the POX3 (X=F, Cl, Br, I) series of molecules","resumen":"The fourth member of the series of compounds of the type POX3 with X= I was synthesized and characterized by infrared spectroscopy. The geometrical parameters and vibrational properties of POX3 (X=F, Cl, Br, I) molecules were investigated theoretically by means DFT and ab-initio methods. Available geometrical and vibrational data were used together with theoretical calculations in order to obtain a set of scaled force constants. The observed trends in geometrical parameters are analyzed and compared with those obtained in a previous work for the VOX3 (X=F, Cl, Br, I) series of compounds. NBO analysis was performed in order to know the hyper-conjugative interactions that favor one structure over another. The molecular properties such as ionization potential, electron affinity, electronegativity, chemical potential, chemical hardness, softness and global electrophilicity index have been deduced from HOMO ?LUMO analysis.","palabras_clave":"Synthesis|Infrared|Raman|Chemical calculations"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17359,"idioma_id":4,"titulo":"Ab-initio and DFT calculations on molecular structure, NBO, HOMO-LUMO study and a new vibrational analysis of 4-(dimethylamino) benzaldehyde","resumen":"The experimental and theoretical study on the molecular structure and a new vibrational analysis of 4-(Dimethylamino) Benzaldehyde (DMABA) is presented. The IR and Raman spectra were recorded in solid state. Optimized geometry, vibrational frequencies and various thermodynamic parameters of the title compound were calculated using DFT methods and are in agreement with the experimental values. A detailed interpretation of the IR and Raman spectra of the title compound were reported. The stability of the molecule arising from hyper-conjugative interactions and charge delocalization has been analyzed using NBO analysis and AIM approach. The HOMO and LUMO analysis were used to determine the charge transfer within the molecule and some molecular properties such as ionization potential, electron affinity, electronegativity, chemical potential, hardness, softness and global electrophilicity index. The TD-DFT approach was applied to assign the electronic transitions observed in the UV?visible spectrum measured experimentally. Molecular electrostatic potential map was performed by the DFT method. According to DSC measurements, the substance presents a melting point of 72.34 °C and decomposes at temperatures higher than 193 °C.","palabras_clave":"DFT calculations|IR and Raman spectroscopy|HOMO-LUMO analysis|, AIM approach"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17360,"idioma_id":4,"titulo":"FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states","resumen":"Interactions of L-cysteine ethyl ester hydrochloride (CE), a bioactive cysteine derivative, with dipalmitoylphosphatidylcholine  (DPPC) were investigated. To gain a deeper insight into analyzing L-cysteine ethyl ester HCl interaction with liposomes of DPPC  in anhydrous and hydrated states, we performed experimental studies by infrared (Fourier transform infrared spectroscopy)  and Raman spectroscopies. The results revealed that the interaction of CE with the phospholipid head groups was the same in absence  or presence of water. In both states, the wavenumber of the PO2   group and C?N bond of the choline group decreased. This  behavior can be ascribed to the replacement of hydration water and binding to the phosphate group. In the Raman spectrum results  for the anhydrous and gel states, the S?H stretching band of the CE shifted to lower frequencies with a decrease in its force  constant. Biologically active lipophilicmolecules such as CE should be studied in terms of their interaction with lipid bilayers prior  to the development of advanced lipid carrier systems such as liposomes. The results of these studies provide information onmembrane  integrity and physicochemical properties that are essential for the rational design of lipidic drug delivery systems.","palabras_clave":"phospholipid hydrations| DPPC bilayers|L-cysteine ethyl ester| FTIR and Raman spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17361,"idioma_id":4,"titulo":"Component Based Model Driven Development - An Approach for Creating Mobile Web Applications from Design Models","resumen":"Current MDD methodologies are complex to use and require doing lots of models and configurations. Usually after all that effort only some part of the application source code can be automatically created. It would be desirable to have a more simple technique, but powerful enough for automatically creating a fully functional application. This works introduces a component based model driven development approach where a set of user interface components will be configured to define system behavior. Component configuration will be direct, simple and supported by a modeling tool which also includes automatic transformations for reducing the modeling task.  The methodology requires the designer to build only two models: a class diagram, representing the data model of the application and a component diagram defining the user interface and the system navigation. Both components are based on UML extended with stereotypes and tagged values allowing configuring the system behavior","palabras_clave":"MDD|Models|Mobile Web Applications|UML|Components|Transformations"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17362,"idioma_id":4,"titulo":"Comment on ?Point charge in a three-dielectric medium with planar interfaces?","resumen":"El trabajo comienza el texto sin un resumen","palabras_clave":"electrostatic field|dielectric medium|planar interfaces"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17363,"idioma_id":5,"titulo":". Estudio exploratorio de la interacción Xanthogaleruca  luteola ? Ulmus spp. en la ciudad de Córdoba","resumen":"Xanthogaleruca luteola (Coleoptera: Chrysomelidae) es un herbívoro especialista, cuyos estados inmaduros y adultos son folívoros en árboles del género Ulmus. El objetivo de este trabajo fue explorar algunos aspectos de la interacción X. luteola-Ulmus spp. en la ciudad de Córdoba. En barrios de la ciudad con distinto grado de urbanización, se ubicaron y georreferenciaron un número variable de olmos. La herbivoría se midió en tres oportunidades, y se relacionó con la especie de olmo, aislamiento, diámetro del tronco y altura de los ejemplares, y con la orientación geográfica del follaje. Los datos se analizaron mediante ANOVA, análisis de regresión lineal y correlación de Spearman. Al final de las dos temporadas el 100% de los ejemplares muestreados presentaron algún indicio de daño, con valores que oscilaron entre 20 y 50% de hojas dañadas. Ulmus procera fue la especie más dañada y los mayores porcentajes de daño foliar se registraron en barrios periféricos. A comienzos de temporada se observó mayor herbivoría en árboles más altos y de mayor diámetro. No se registraron diferencias significativas en el daño foliar causado por el insecto en las distintas orientaciones del follaje, ni hubo relación entre el daño foliar y el índice de urbanización.","palabras_clave":"ambientes urbanos|urbanización|insectos fitófagos|vaquita del olmo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17364,"idioma_id":4,"titulo":"Screening of native plants from central Argentina against the leaf-cutting ant Acromyrmex lundi (Guérin) and its symbiotic fungus","resumen":"Leaf-cutting ants are major agricultural and forestry pests in the New World. Attempts to control themhave most frequently involved the use of chemical insecticides, with mixed results. Among alternativemethods, botanical pesticides may provide a sustainable and efficient control of leaf-cutting ants. In thepresent study, we screened the activity of plant extracts derived from 89 species native to Argentina,against the leaf-cutting ant Acromyrmex lundi (Guérin) and its mutualistic fungus, Leucoagaricus gongy-lophorus, through a pick-up assay and bioautography, respectively. The pick-up assay revealed moderateto strong anti-foraging activity for just over 13.5% of the assayed species, including complete ant foraginginhibition for Aristolochia argentina, Flourensia oolepis, Gaillardia megapotamica, Lantana grisebachii andLithrea molleoides. Most plant extracts were well tolerated by fungi, with only 12.3% of the species testedshowing some degree of fungus growth inhibition. Among these, A. argentina, F. oolepis and Pterocaulonalopecuroides were the strongest inhibitors, whereas Baccharis flabellata, Dalea elegans and Zanthoxylumcoco revealed a more moderate activity. Only A. argentina and F. oolepis extracts showed strong antifor-aging effects and affected fungus growth at the same time. Values of IC50and MIC indicated that extractsinhibiting ant foraging at lower concentrations did not necessarily also inhibit fungus growth at lowerdoses. The active principle of A. argentina, on both ant foraging and fungal growth, was identified asargentilactone.","palabras_clave":"Acromyrmex lundi |Aristolochia argentina|argentilactona|antiforrajeo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17365,"idioma_id":4,"titulo":"Insights from an integrated view of the biology of apple snails (Caenogastropoda, Ampullariidae)","resumen":"Apple snails (Ampullariidae) are among the largest and most ecologically important freshwater snails. The introduction of multiple species has reinvigorated the field and spurred a burgeoning body of research since the early 1990s, particularly regarding two speciesintroduced to Asian wetlands and elsewhere, where they have become serious agricultural pests. This review places these recent advances in the context of previous work, across diverse fields ranging from phylogenetics and biogeography through ecology and developmental biology, and the more applied areas of environmental health and human disease. The review does not deal with the role of ampullariids as pests, nor their control and management, as this has been substantially reviewed elsewhere. Despite this large and diverse body of research, significant gaps in knowledge of these important snails remain, particularly in a comparative framework. The great majority of the work to date concerns a single species, Pomacea canaliculata, which we see as having the potential to become a model organism in a wide range of fields. However additional comparative data are essential for understanding this diverse and potentially informative group. With the rapid advances in genomic technologies, many questions, seemingly intractable two decades ago, can be addressed, and ampullariids will provide valuable insights to our understanding across diverse fields in integrative biology.","palabras_clave":"behavior|ecology|evolution|freshwater|Gastropoda|review"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17366,"idioma_id":4,"titulo":"A study on the effect of ternary interaction parameters on the equation of state description of ternary fluid phase equilibria","resumen":"Models of the equation of state (EOS) type, used for describing fluid phase equilibria, typically assume that the system behavior can be described from binary contributions only. This is not enough for obtaining good predictions for the high-pressure phase equilibria of ternary highly non ideal systems. On the other hand, cubic mixing rules (CMRs) provide both, binary and ternary interaction parameters. Such ternary parameters have the potential of improving the reproduction of ternary experimental data while leaving invariant the description of the three constituent binary subsystems. In this work, we evaluate the possibilities of the CMRs approach for ternary systems by studying the phase equilibria of two of them, i.e., CO2+n-hexadecane+1,8-octanediol and CO2+H2O+2-propanol. For the system CO2+n-hexadecane+1,8-octanediol, we have available both, experimental isothermal binary and ternary phase equilibrium data. For such system, we investigate the influence of the ternary parameters on the size of ternary two-phase and three-phase equilibrium regions, and compare it to that of the experimental data. We also consider predicted values of the ternary parameters, which we need when ternary experimental data are not available. For the system CO2+H2O+2-propanol, we examine the effect of the ternary interaction parameters on some calculated ternary univariant lines, ternary invariant points and ternary three-phase equilibria, over wide ranges of conditions.In this study, we use the Peng-Robinson (PR) EOS and Soave-Redlich-Kwong (SRK) EOS, both coupled to CMRs. Our results make evident the flexibility and improvement that can be gained in the description of ternary phase equilibria by resorting to ternary interaction parameters","palabras_clave":"HIGH PRESSURE|TERNARY SYSTEMS|TERNARY INTERACTION PARAMETERS|PHASE EQUILIBRIA|EQUATION OF STATE|CUBIC MIXING RULES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17367,"idioma_id":5,"titulo":"YOGUR FUNCIONAL Y REDUCIDO EN LACTOSA:  CARACTERÍSTICAS FISICOQUÍMICAS Y SENSORIALES","resumen":"La intolerancia a la lactosa es un problema que afecta alrededor del 70% de la población mundial, su incidencia en América del Sur es muy elevada.El propósito del presente trabajo fue elaborar yogures deslactosados mediante la incorporación de la enzima &#946;-galactosidasa (EC.3.2.1.23) proveniente de Kluyveromyces lactis, y con la adición de una bacteria probiótica (Lactobacillus acidophilus, La-5) y de una sustancia prebiótica (inulina), y analizar las características fisicoquímicas, de textura y de flavor. Se evaluó además el impacto sensorial de estos nuevos productos en los consumidores, de manera de valorar la factibilidad de su incorporación al mercado argentino.","palabras_clave":"Intolerancia a la lactosa|yogur deslactosado|analisis sensorial"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17368,"idioma_id":5,"titulo":"La permanencia de las tendencias globales y la emergencia de nuevas economías  en la geografía del comercio internacional","resumen":"Este trabajo sintetiza algunos de los principales resultados y los nuevos interrogantes surgidos de los proyectos de investigación que han realizado, en su continuidad, un estudio exploratorio de la geografía del comercio internacional.  Estos estudios muestran, por un lado, que el peso principal del intercambio de mercancías y servicios se verifica entre los principales países y regiones desarrolladas del mundo, con un predominio intra-sectorial industrial, en el marco de la nueva división internacional de la producción que incentiva el comercio intra-firma ante el predominio de las empresas trasnacionales y la conformación de cadenas globales de valor. Por otro lado, en especial desde inicios del siglo XXI, se destaca la creciente participación de economías en desarrollo y el aumento de la cooperación Sur-Sur que redefine la economía global y el paisaje comercial. Así la ?vieja? geografía del comercio internacional, donde el Sur ha servido como hinterland de recursos y mercados cautivos para los bienes terminados del Norte, parecería estar cambiando al crecer en las últimas décadas su peso en el comercio global.","palabras_clave":"GEOGRAFÍA DEL COMERCIO INTERNACIONAL|CADENAS GLOBALES DE VALOR|COOPERACIÓN SUR-SUR|ECONOMÍAS EMERGENTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17369,"idioma_id":4,"titulo":"A Strategy for Solving the Non Symmetries Arising i n Nonlinear Consolidation of Partially Saturated Soils","resumen":"The main scope of this paper is to present an alternative to tackle the problem of the non symmetries arising in the solution of the nonlinear couple consolidation problem based on a combination of different stress states. Being originally a non symmetric problem, it may be straightforward reduced to a symmetric one, and the conditions in which this reduction may be carried out, are addressed. Non linear saturation-suction and permeability-suction functions were regarded. The geometric model was developed considering an updated lagrangian description with a co-rotated Kirchhoff stress tensor. This description leads to a non-symmetric stiffness matrix and a simple alternative, using a symmetric constitutive matrix, is addressed to overcome this situation. The whole equation system was solved using an open finite element code FECCUND, developed by the authors. In order to validate the model, various examples, for which previous solutions are known, were solved. The use of either a strongly non linear and no symmetric formulation or a simple symmetric formulation with accurate prediction in deformation and pore-pressures is extremely dependent on the soil characteristic curves and on the shear efforts level, as well. A numerical example show the predictive capability of this geometrically non linear fully coupled model for attaining the proposed goal.","palabras_clave":"Hypoelastic Formulations|Finite Element Analysis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17371,"idioma_id":4,"titulo":"Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients","resumen":"Background: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake.   Methods: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015.  Results: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts.   Conclusions: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.","palabras_clave":"TRIATOMA VIRUS|TRIATOMINES|DICISTROVIRIDAE|CHAGS DISEASE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17372,"idioma_id":5,"titulo":"Implementación de un modelo matemático distribuido de escurrimiento superficial en la cuenca del río Tercero - Carcaraña","resumen":"Se presenta la implementación y calibración preliminar de un modelo matemático distribuido, hidrológico-hidráulico  físicamente basado en la cuenca del río Tercero-Carcarañá (provincias de Córdoba y Santa Fe). La cuenca tiene una  superficie de aproximadamente 61.454 km² y su principal curso es el río Tercero - Carcarañá, con descarga al río Coronda a  la altura de Puerto Gaboto. Se utilizó como modelo digital del terreno la información proveniente de la misión SRTM, con  agregamiento en celdas de 900 m x 900 m. Adicionalmente se contó con información de red de cursos desde cartas  topográficas del IGN, imágenes Google Earth ©; recorridas de campo y proyectos existentes. El modelo quedó constituido con  75.870 celdas y una red de cursos de 1.705 km y fue calibrado preliminarmente con información hidrológica e hidráulica  de tres eventos extraordinarios. Para avanzar en el conocimiento de la mecánica de propagación del escurrimiento una  primer aplicación consistió en la determinación de la incidencia de los aportes superficiales provenientes de unidades areales  elementales en 17 puntos característicos de la red de cursos principales. Si bien se evidencia un severo déficit de información,  los primeros resultados obtenidos en la transformación lluvia caudal y propagación de escurrimiento superficial son  aceptables.","palabras_clave":"GRANDES CUENCAS DE LLANURA|MODELACION MATEMATICA DISTRIBUIDA|RIO CARCARAÑA-TERCERO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17373,"idioma_id":4,"titulo":"Modelling the potential geographic distribution of triatomines infected by Triatoma virus in the southern cone of South America","resumen":"Background: Triatoma virus (TrV) is the only entomopathogenous virus identified in triatomines. We estimated thepotential geographic distribution of triatomine species naturally infected by TrV, using remotely sensed andmeteorological environmental variables, to predict new potential areas where triatomines infected with TrV maybe found.Methods: Detection of TrV infection in samples was performed with RT-PCR. Ecological niche models (ENM) wereconstructed using the MaxEnt software. We used 42 environmental variables derived from remotely sensed imagery(AVHRR) and 19 bioclimatic variables (Bioclim). The MaxEnt Jackknife procedure was used to minimize the numberof environmental variables that showed an influence on final models. The goodness of fit of the model predictionswas evaluated by the mean area under the curve (AUC).Results: We obtained 37 samples of 7 species of triatomines naturally infected with TrV. Of the TrV positivesamples, 32% were from sylvatic habitat, 46% came from peridomicile habitats and 22% from domicile habitats. Fiveof the seven infected species were found only in the sylvatic habitat, one species only in the domicile and onlyTriatoma infestans was found in the three habitats. The MaxEnt model estimated with the Bioclim dataset identifiedfive environmental variables as best predictors: temperature annual range, mean diurnal range, mean temperatureof coldest quarter, temperature seasonality and annual mean temperature. The model using the AVHRR datasetidentified six environmental variables: minimum Land Surface Temperature (LST), minimum Middle InfraredRadiation (MIR), LST annual amplitude, MIR annual amplitude annual, LST variance and MIR variance. The potentialgeographic distribution of triatomine species infected by TrV coincides with the Chaco and the Monte ecoregionseither modelled by AVHRR or Bioclim environmental datasets.Conclusions: Our results show that the conditions of the Dry Chaco ecoregion in Argentina are favourable for theinfection of triatomine species with TrV, and open the possibility of its use as a potential agent for the biologicalcontrol of peridomestic and\/or sylvatic triatomine species. Results identify areas of potential occurrence that shouldbe verified in the field.","palabras_clave":"Triatoma virus|Triatominae|Ecological Niche Modelling|MaxEnt, 66 WorldClim|AVHRR imagery"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17374,"idioma_id":4,"titulo":"Fibre enrichment of wheat bread with Jerusalem artichoke inulin: Effect on dough rheology and bread quality","resumen":"Dietary fibre enrichment of white bread with inulin-rich carbohydrate (IRC) powder  extracted from Jerusalem artichoke tubers (IRC-J) was studied. Previously, it was shown that this IRC-J powder had higher prebiotic activity score than a commercial chicory inulin (IRC-C) powder, used for comparison. For bread making, 2.5 and 5.0 g of either IRC-J or IRC-C were added to 100 g of wheat flour, and the effects on dough viscoelastic properties and bread quality properties were analyzed, relative to a Control sample (no IRC added). The lowest IRC concentration of both fibres had no significant effect on the elastic modulus (G0) of the dough, but the highest IRC level decreased G0, with a stronger effect of IRC-J. This was attributed to disruption of the starch gluten matrix due to fibre replacement of flour. In turn, this was thought to impair gas retention (known as diluting effect), resulting in the observed decrease of bread specific volume and cell\/total area ratio, and the increase in crumb hardness and chewiness. IRC addition also had a significant effect on crumb and crust colour, and other crumb grain features. These effects were more significant at the highest IRC concentration of both fibres. Breads with 5.0 g of IRC-J were significantly darker, flatter, and more humid. All the sensory attributes of breads with 0 (Control sample), 2.5 g IRC-J, and 2.5 g IRC-C were acceptable, and no significant differences were found between the three samples, in any of the attributes.","palabras_clave":"DIETARY FIBRE|INULIN|WHEAT FLOUR|DOUGH|BREAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17375,"idioma_id":4,"titulo":"Passivity-based Visual Feedback Control with Dynamic Compensation of Mobile Manipulators: Stability and L2-Gain Performance Analysis","resumen":"This paper addresses the problem of visual dynamic control based on passivity  to solve the target tracking problem of mobile manipulators with eyes-in-hand  configuration in the 3D-workspace. The redundancy of the system is used for obstacles  avoidance and singular configuration prevention through the system?s manipulability  control. The design of the stable control system is based on its passivity properties. A  robustness analysis and an L2-gain performance analysis are also presented. Finally,  simulation and experimental results are reported to verify the stability and L2-gain  performance of the dynamic visual feedback system.","palabras_clave":"MOBILE MANIPULATOR|PASSIVITY-BASED CONTROL|NON-LINEAR CONTROL|VISUAL SERVOING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17376,"idioma_id":4,"titulo":"Characterization of polyphenols and evaluation of antioxidant capacity in grape pomace of the cv. Malbec","resumen":"Low molecular weight polyphenols (LMW-PPs) and anthocyanins, along with the antioxidant capacity, were assessed in grape pomace extract (GPE) of red grape (Vitis vinifera L.) cv. Malbec. Twenty six phenolics (13 LMW-PPs and 13 anthocyanins) were characterized and quantified by HPLC-MWD and UPLC-ESI-MS. The maximum concentrations of LMW-PPs corresponded to the flavanols (+)-catechin and (-)-epicatechin, whereas malvidin-3-glucoside was the most abundant anthocyanin. Piceatannol, a stilbene analogue to resveratrol with higher antioxidant activity, was firstly identified and quantified in GPE of the cv. Malbec. The antioxidant activity for Malbec GPE determined by oxygen radical absorbance capacity (ORAC) assay was 2756 µmol TE g-1 GPE. Therefore, the data reported sustain the use of winemaking by-products as a cheap source of phenolic compounds suitable for biotechnological applications, as a strategy for sustainable oenology.","palabras_clave":"GRAPE POMACE|MALBEC|POLYPHENOLS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17377,"idioma_id":4,"titulo":"Complementary Gaussian Mixture Models for Multimodal Speech Recognition","resumen":"In speech recognition systems, typically, each word\/phoneme in the vocabulary is represented by a model trained with samples of each particular class. The recognition is then performed by computing which model best represents the input word\/phoneme to be classified. In this paper, a novel classification strategy based on complementary class models is presented. A complementary model to a particular class j refers to a model that is trained with instances of all the considered classes, excepting the ones associated to that class j. This work describes new multi-classifier schemes for isolated word speech recognition based on the combination of standard Hidden Markov Models (HMMs) and Complementary Gaussian Mixture Models (CGMMs). In particular, two different conditions are considered. If the data is represented by single feature vectors a cascade classification scheme using HMMs and CGMMs is proposed. On the other hand, when data is represented by multiple feature vectors, a classification scheme based on a voting strategy which combines scores from individual HMMs and CGMMs is proposed. The classification schemes proposed in this paper are evaluated over two audio-visual speech databases, considering acoustic noisy conditions. Experimental results show that improvements in the recognition rates through a wide range of signal to noise ratios are achieved with the proposed classification methodologies.","palabras_clave":"SPEECH RECOGNITION|AUDIO-VISUAL INFORMATION FUSION|DECISION LEVEL FUSION|COMPLEMENTARY MODELS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17378,"idioma_id":4,"titulo":"The skin structure of greater rhea (Rheidae, Palaeognathae)","resumen":"The aim of this study was to describe the histological structure of the skin of greater rhea (Rhea americana), a ratite bird native to South America. Skin samples were taken from three regions of the trunk (alar, dorsal and pelvic) in 14 specimens which ages ranged from seven days to adulthood. Serial sections were obtained and subjected to different staining procedures  (hematoxylin and eosin, orcein, Masson?s trichrome and Gomori) and a morphometric analysis was carried out on stained slides.  In general, both epidermis and dermis showed increased thickness of its layers with age. Some differences between regions can be detected both in epidermis and dermis, as example, in adults and 7-day-old birds, the stratum corneum of the alar region was thicker than of the dorsal region. In general, the skin of greater rhea was similar to that described in ratites and other birds (a thin epidermis compared to dermis, dermis with scarce elastic fibres, a slender and vascularized stratum superficiale, collagen fibres arranged in three directions). The scarcity of elastic fibres and the general cross-weaved arrangement of the collagen fibres in the dermis of the adult greater rhea provide strength and flexibility to the dermis, two important features in leather industry.","palabras_clave":"birds|integument|dermis|epidermis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17379,"idioma_id":4,"titulo":"Anti-thyroid and antifungal activities, BSA interaction and acid phosphatase inhibition of methimazole copper (II) complexes","resumen":"It has been reported that various metal coordination compounds have improved some biological properties.A high activity of acid phosphatase (AcP) is associated to several diseases (osteoporosis, Alzheimer?s,prostate cancer, among others) and makes it a target for the development of new potential inhibitors.Anti-thyroid agents have disadvantageous side effects and the scarcity of medicines in this area motivated many researchers to synthesize new ones. Several copper(II) complexes have shown antifungal activities. In this work we presented for a &#64257;rst time the inhibition of AcP and the anti-thyroid activity produced by methimazole?Cu(II) complexes. Cu?Met ([Cu(MeimzH)2(H2O)2](NO3)2HO) produces a weak inhibition action while Cu?Met?phen ([Cu(MeimzH)2(phen)(H2O)2]Cl22) shows a strong inhibition effect(IC= 300 lM) being more effective than the reported behavior of vanadium complexes. Cu?Met?phen also presented a fairly good anti-thyroid activity with a formation constant value, K50 being 106times more active than methimazole (Kc= 4.16  104M1) in opposition to Cu?Met which presented activity (Kc= 9.54  103M1) but in a lesser extent than that of the free ligand. None of the complexes show antifungal activity except Cu?phen (MIC = 11.71 lgmL1 on Candida albicans) which was tested for comparison. Besides, albumin interaction experiments denoted high af&#64257;nity toward the complexes and the calculated binding constants indicate reversible binding to the protein.c= 1.02  1010M1","palabras_clave":"Methimazole|Phenanthroline|Copper(II)|Antifungal activity|Anti-thyroid activity|BSA interactions"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17380,"idioma_id":4,"titulo":"Talc nanoparticles influence on thermoplastic corn starch film properties","resumen":"Nanocomposite films of TPS with talc particles were obtained by thermo-compression in order to study the effect of this filler on structure, optical, and thermal properties. TPS-talc films showed good appearance and homogeneous thickness. Talc addition increased the amount of rigid phase of nanocomposite films, thus their cross-sections resulted more irregular than those of TPS ones. Talc preferential orientation within matrix and good compatibility between particles and TPS were evidenced. TEM observation showed scattered randomly dispersed individual talc platelets. Matrix crystallinity degree was not significantly affected by particles presence. Nanocomposite films were optically transparent due to the laminar morphology and nanosized particles. Materials microstructure presented glycerol- and starch-rich domains. Talc incorporation higher than 3 % w\/w increased softening resistance of nanocomposites as stated by DMA assays. TPS relaxation temperature of glycerol-rich phase was shifted to higher values since talc nanoparticles reduce starch chains mobility.","palabras_clave":"THERMOPLASTIC CORN STARCH|TALC NANOPARTICLES|FILM|MICROSTRUCTURAL CHARACTERIZATION|OPTICAL PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17381,"idioma_id":4,"titulo":"Reduction in voluntary ethanol intake following repeated oral administration of Jodina rhombifolia lyophilized aqueous extract in male Wistar rats","resumen":"Journal of Ethnopharmacology (Impact Factor: 2.94). 12\/2014; DOI: 10.1016\/j.jep.2014.12.019   Source: PubMed        Edit      ABSTRACT The leaves of Jodina rhombifolia (Hook. & Arn.) Reissek (SANTALACEAE) is utilized in Argentine folk medicine for the treatment of alcoholism.   To evaluate the antialcoholic activity of J. rhombifolia lyophilized aqueous extract (JRLE) in male Wistar rats.   Rats were housed individually in standard plastic cages with wood chip bedding. Throughout the duration of experiment, ethanol was offered in the standard home-cage; two-bottle free-choice regimen between an ethanolic solution (20% in tap water, v\/v) and tap water with unlimited access for 24 hours per day for 10 consecutive days. Rats were administrated intragastrically twice daily (1 ml\/200 g) for 10 consecutive days, with the control vehicle (distilled water) or one of the doses of JRLE (125, 250 and 500 mg\/Kg weight). Body weight, ethanol, water and food intake were measured every day at the same hour during the 10 days of experimentation. The reducing effect of JRLE on daily ethanol intake was evidenced from the first day of treatment and persisted throughout the entire treatment period. The treatment did not significantly affect daily water intake neither the body weight gain. Daily food intake was higher in rat groups treated with JRLE.   The results obtained in the present preliminary study show that repeated administration of JRLE, markedly reduces ethanol voluntary intake in male Wistar rats. The reduction of consumption was of remarkable magnitude and stable during the treatment 10-day.","palabras_clave":"Jodina rhombifolia|ethanol |antialcoholic actovity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17382,"idioma_id":4,"titulo":"Storage-induced changes in functional properties of glycerol plasticized e Soybean protein concentrate films produced by casting","resumen":"Aging of soybean protein concentrate (SPC) films plasticized by glycerol obtained by casting and stored at 25 ± 2 C and 65 ± 2% relative humidity was systematically investigated over a period of 90 days. Aging promoted the reorganization of the secondary structure of protein fraction in SPC into others with prevalence of extended b-sheet conformation. Stabilizing interactions also progressed to increasing contribution of disulfide cross-links and Maillard aggregates through the carbohydrate fraction of SPC. Such time-dependent structural changes were ineffective in retaining glycerol within the films. This caused increased strength and stiffness with time. Water vapor permeability values increased up to 90th day due to micro-cracks created by film contractions during storage, which create more permeable structures which hamper the determination of oxygen permeability on aged films. As a general trend, films functional properties remained stable for two weeks under specific storage conditions preserving enough mechanical and barrier properties to act as efficient protective food packaging materials.","palabras_clave":"Soybean protein concentrate|film|aging|casting"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17383,"idioma_id":4,"titulo":"Intranasal administration of TLR agonists induces a discriminated local innate response along murine respiratory tract","resumen":"AbstractAdjuvants are relevant for mucosal immunization in order to induce long lasting protective immu- nity. It has been shown that targeting to different regions of the airway results in different capacity to trigger adaptive\/protective immunity. Nevertheless there is scarce knowledge regarding topological responsiveness along airways to TLR agonists. We analyzed the effects of intranasal administration of lipopolysaccharide (LPS), poly I:C and flagellin on the expression of a panel of innate response markers along murine airways by laser microdissection and RTqPCR. In all cases treatment induced recruitment of inflammatory cells to airways. However, regional gene expression indicated that whereas deeper airways (mainly alveoli) respond with high expression of IL6, CXCL1 and CXCL10, the response in conductive air- ways (bronchi and bronchioles) is dominated by expression of CCL20. On the other hand, triggering TLR3 elicits a response dominated by CXCL10, showing higher expression at 6 h compared to 2 h, whereas LPS and flagellin induce a response peaking at 2 h and dominated by IL6 and CXCL1. The results presented here showed difference in topological response triggered by different TLR agonist. These results make the targeting of different sites of airways a variable to evaluate when selecting the appropriate combinations of TLR and vaccinal antigens for intranasal delivery.","palabras_clave":"Toll like receptors|TLR agonist|airways|innate response"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17384,"idioma_id":4,"titulo":"Ionic Fragmentation Mechanisms of 2,2,2-Trifluoroethanol Following Excitation with Synchrotron Radiation","resumen":"Gaseous 2,2,2-trifluoroethanol (TFE) is excited with synchrotron radiation between 10 and 1000 eV and the ejected electrons and positive ions are detected in coincidence. In the valenceelectronenergy region, the most abundant species is CH2OH+. Other fragments, including ions produced by atomic rearrangements, are also detected; the most abundant are COH+, CFH2+ and CF2H2+. The energies of electronic transitions from C 1 s, O 1s and F 1 s orbitals to vacant molecular orbitals are determined. A site-specific C 1s excitation is observed. The photofragmentation mechanisms after the excitation of coreshell electrons are inferred from analysis of the shape andslope of the coincidence between two charged fragments in the bi-dimensional coincidence spectra. The spectra are dominated by islands that correspond to the coincidence of H+with several charged fragments. One of the most important channels leads to the formation of CH2OH+ and CF3+ in a concerted mechanism.","palabras_clave":"synchrotron radiation|PHOTOIONIZATION|INNER SHELL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17385,"idioma_id":4,"titulo":"Essentially commuting projections","resumen":"Let H=H+&#8853;H&#8722; be a fixed orthogonal decomposition of a Hilbert space, with both subspaces of infinite dimension, and let E+,E&#8722; be the projections onto H+ and H&#8722;. We study the set Pcc of orthogonal projections P   in H which essentially commute   with E+ (or equivalently with E&#8722;), i.e.      Turn MathJax on    By means of the projection &#960;   onto the Calkin algebra, one sees that these projections P&#8712;Pcc fall into nine classes. Four discrete   classes, which correspond to &#960;(P) being 0, 1, &#960;(E+) or &#960;(E&#8722;), and five essential   classes which we describe below. The discrete classes are, respectively, the finite rank projections, finite co-rank projections, the Sato Grassmannian of H+ and the Sato Grassmannian of H&#8722;. Thus the connected components of each of these classes are parametrized by the integers (via de rank, the co-rank or the Fredholm index, respectively). The essential classes are shown to be connected.  We are interested in the geometric structure of Pcc, being the set of selfadjoint projections of the C&#8270;-algebra Bcc of operators in B(H) which essentially commute with E+. In particular, we study the problem of existence of minimal geodesics joining two given projections in the same component. We show that the Hopf?Rinow Theorem holds in the discrete classes, but not in the essential classes. Conditions for the existence and uniqueness of geodesics in these latter classes are found.","palabras_clave":"Projection|compact operator"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17386,"idioma_id":4,"titulo":"Effect of antioxidant active films on the oxidation of soybean oil monitored by Fourier transform infrared spectroscopy","resumen":"    An active film prepared from waterborne  polyurethane incorporated with different concentrations of butylated  hydroxytoluene (BHT) and &#945;-tocopherol was developed, and the films? antioxidant characteristics  were studied using soybean oil as food model. The release behavior of additives  from such films was studied using isooctane as a simulant fatty food.  Antioxidant activity of the films into soybean oil at three experimental  conditions was monitored by FTIR spectroscopy. Induction time and the kinetics  of the oxidation process were followed using different bands of the FT-IR  spectra. Films incorporated with 2&nbsp;wt.% of BHT or &#945;-tocopherol showed enough  antioxidant activity to preclude oil oxidation during 60&nbsp;days at  60&nbsp;°C in the dark. The results showed that this type of active films could  be used for food preservation as part of a packaging containing oils or oily  related products.  ","palabras_clave":"ANTIOXIDANT ACTIVE FILMS|SOYBEAN OIL|OIL OXIDATION|FOURIER TRANSFORM INFRARED SPECTROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17387,"idioma_id":4,"titulo":"Effects of traffic compaction on soil pore configuration","resumen":"Soil compaction has been recognized as a severe problem in mechanized agriculture and has an influence on many soil properties and processes. Long-term  effects  of  soil  compaction have  seldom  been documented, and the  persistence  of  soil  compaction  is  often  measured  with  a limited  number  of  soil  parameters. The objectives of this study were to evaluate the persistence of soil compaction effects (three traffic treatments: T0: non trafficked; T3. Three tractor passes; and T5: five tractor passes) on pore system configuration, through static and dynamic determinations; and to determine changes on soil pore orientation due to soil compaction through the measurement of saturated hydraulic conductivity in vertical and horizontal samples. The traffic produced persistent changes on all the studied dynamic indicators (saturated hydraulic conductivity, K0, effective macro and mesoporosity, &#949;ma, and &#949;me), with significant lower values of K0, &#949;ma, and &#949;me in T5 treatment. The static indicators bulk density (BD), derived total porosity (TP), and total macroporosity (&#952;ma) did not varied significantly between treatments. This means that the traffic did not produce persistent changes on these variables after 2 years. The soil pore orientation was also modified by traffic, with higher vertical K0 than horizontal K0 in T0, related to the presence of vertical bipores, and isotropy in K0 in the trafficked treatments. Overall, the results showed that dynamic indicators are more sensitive to compaction effects, and furthermore, that static indicators should not be used as compaction indicators, without using accompanying dynamic indicators.","palabras_clave":"Effective porosity|Total porosity|soil pore anisotropy|hydraulic conductivity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17388,"idioma_id":4,"titulo":"A metaphylactic treatment with double dose oxytetracycline  reduces the risk of bovine respiratory disease in feedlot calves","resumen":"Fazzio, L.E.;Giuliodori, M.J.; Galván, W.R.; Streitenberger, N.; Landoni, M.F.: A metaphylactic treatment with double dose oxytetracycline reduces therisk of bovine respiratory disease in feedlot calves. Rev. vet. 26: 2, XX-XX,2015.The objective of this study was to evaluate the effect of a metaphylactictreatment with oxytetracycline (OTC) in the labeled and double doses on therisk for bovine respiratory disease (BRD) in feedlot calves. This study wasconducted in a commercial feedlot where 2,754 calves belonging to high riskgroups were enrolled. A randomized complete block design was used, with animalsas experimental units and pens (n=10) as blocks. Three experimental groups wereassessed: 1- untreated control (CTL), 2- OTC 20 mg\/kg SC (OTC20) and 3- OTC 40mg\/kg SC (OTC40). The risk for BRD was evaluated with a mixed logistic regression.Untreated CTL had 2.85 and 7.14 more chances of getting BRD than OTC20 andOTC40 groups, respectively (p&lt;0.001). In conclusion, metaphylactic treatmentwith OTC is useful to reduce the risk for BRD in feedlot cattle, beingprotective effect higher at double dose than at labeled one.","palabras_clave":"calf| respiratory disease| oxytetracycline| metaphylactic"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17389,"idioma_id":4,"titulo":"SODIUM CASEINATE FILMS CONTAINING LINSEED OIL RESIN AS OILY MODIFIER","resumen":"Modified sodium caseinate films were prepared by casting of film forming emulsions prepared by adding different contents of a linseed oil based resin (LOR) into the aqueous protein solution. Infrared spectroscopy of the formed films revealed that physical interactions between the main component of the film and the oily modifier were developed. The films were also characterized in terms of water vapor permeability, water absorption, optical, mechanical and thermal properties. Water vapor permeability and equilibrium moisture content decreased with the addition of LOR, reaching their minimum values (59% reduction in WVP and about 70% reduction in EMC, respect to the corresponding values of the neat SC film) with the incorporation of 10 and 15 wt% of LOR, respectively. As expected, contact angle measured using a polar solvent and opacity increase (respect to the neat SC film) when the lipid modifier is used in the formulation, although the increment in the last property is lower than the reported in similar works. The presence of LOR decreased tensile modulus and strength but the elongation at break is not significantly affected.","palabras_clave":"SODIUM CASEINATE|LINSEED OIL BASED RESIN|FILMS|EMULSION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17390,"idioma_id":4,"titulo":"WHEAT GLUTEN FILMS OBTAINED BY COMPRESSION MOLDING","resumen":"Edible films based on plasticized wheat gluten protein were prepared by intensive mixing followed by compression molding, a thermoplastic process involving relatively high temperature and high pressure. The effects of water and glycerol, which were selected as plasticizers for the wheat gluten, as well as the processing conditions (mixing time and molding temperature) on the physical and mechanical properties of the films were evaluated. The resulting films were characterized in terms of moisture sorption, total soluble matter, water vapor permeability, dynamic mechanical and tensile properties. It was found that plasticizer type and concentration had a dominating effect on mechanical properties and WVP, while other physical properties remain almost non-affected. Moreover, the effect of the added plasticizer (glycerol) on the film properties strongly depends on natural presence of water in commercial gluten (9% as is). On the other hand, the pressing temperature affected the final properties of the films more than the mixing time because the former influences the final cross-linking degree of the protein network. Moreover, processing temperatures higher than 100 ºC led to darker films that would be discarded by consumers if they were used as food packaging.","palabras_clave":"WHEAT GLUTEN PROTEIN|THERMOPLASTIC PROCESSING|MECHANICAL PROPERTIESMECHANICAL PROPERTIES|PHYSICAL PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17391,"idioma_id":4,"titulo":"Archaeal membrane-associated proteases: insights on Haloferax volcanii and other haloarchaea","resumen":"The function of membrane proteases range from general house-keeping to regulation of cellular processes. Although the biological role of these enzymes in archaea is poorly understood, some of them are implicated in the biogenesis of the archaeal cell envelope and surface structures. The membrane-bound ATP-dependent Lon protease is essential for cell viability and affects membrane carotenoid content in Haloferax volcanii. At least two different proteases are needed in this archaeon to accomplish the posttranslational modifications of the S-layer glycoprotein. The rhomboid protease RhoII is involved in the N-glycosylation of the S-layer protein with a sulfoquinovose-containing oligosaccharide while archaeosortase ArtA mediates the proteolytic processing coupled-lipid modification of this glycoprotein facilitating its attachment to the archaeal cell surface. Interestingly, two different signal peptidase I homologs exist in H. volcanii, Sec11a and Sec11b, which likely play distinct physiological roles. Type IV prepilin peptidase PibD processes flagellin\/pilin precursors, being essential for the biogenesis and function of the archaellum and other cell surface structures in H. volcanii.","palabras_clave":"membrane protease|archaea|cell surface"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17392,"idioma_id":4,"titulo":"Assessment of fate of Argentinean Salmonella  serotypes studied under different conditions of growing factors","resumen":"Salmonella has emerged as the leading cause of human infections in many countries, with poultry and avian environment, being the main source of the pathogen (FAO\/WHO, 2002; Alali et al., 2012). Salmonella control is important for human exposure reduction. The aim of this research was to evaluate the fate of Salmonella serotypes as a result of the effect of pH, temperature (T) and water activity (aw). Assays were done varying one factor each time or all three simultaneously. The effect of initial inoculum size was also analyzed. Strains of Salmonella were isolated from chicken carcasses and avian environment. No Salmonella strain grew at pH 3.6; 60% grew at 3.7; and 100% developed from 3.8. At aw 0.95, all strains grew, but none at 0.94. One strain grew at 5.5ºC, minimum tested temperature. The influence of inoculum size on Salmonella strain fate was demonstrated. Response Surface Methodology (RSM) by Box-Behnken, (1960) was used to evaluate combined effects of parameters on Salmonella Newport. Temperature was the major incident factor, followed by pH and aw. At 20°C, it grew at each combination of pH and aw, whereas at 7°C, decrease was observed in all tests. At 13.5°C, response varied according to pH and aw. Results suggest that adjustments are needed for safety assurance in food production. Data obtained give information from developing countries for Salmonella Risk Assessment in foods.","palabras_clave":"salmonella|growing factors|food safety|salmonella risk assessment"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17393,"idioma_id":4,"titulo":"Origin of the large dispersion of magnetic properties in nanostructured oxides: FexO\/Fe3O4 nanoparticles as a case study","resumen":"The intimate relationship between stoichiometry and physicochemical properties in transition-metal oxides makes them appealing as tunable materials. These features become exacerbated when dealing with nanostructures. However, due to the complexity of nanoscale materials, establishing a distinct relationship between structure-morphology and functionalities is often complicated. In this regard, in the FexO\/Fe3O4 system a largely unexplained broad dispersion of magnetic properties has been observed. Here we show, thanks to a comprehensive multi-technique approach, a clear correlation between the magneto-structural properties in large (45 nm) and small (9 nm) FexO\/Fe3O4 core\/shell nanoparticles that can explain the spread of magnetic behaviors. The results reveal that while the FexO core in the large nanoparticles is antiferromagnetic and has bulk-like stoichiometry and unit-cell parameters, the FexO core in the small particles is highly non-stoichiometric and strained, displaying no significant antiferromagnetism. These results highlight the importance of ample characterization to fully understand the properties of nanostructured metal oxides","palabras_clave":"MAGNETIC NANOPARTICLES|BIMAGNETIC MATERIALS|EXCHANGE BIAS|MAGNETIC PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17394,"idioma_id":4,"titulo":"Conformational and spectroscopic study of xanthogen ethyl formates, ROC(S)SC(O)OCH2CH3.  Isolation of CH3CH2OC(O)SH","resumen":"ROC(S)SC(O)OCH2CH3, with R = CH3-, (CH3)2CH- and CH3(CH2)2-, were obtained through the reaction between potassium xanthate salts, ROC(S)SK, and ethyl chloroformate, ClC(O)OCH2CH3. The liquid compounds were identified and characterized by 1H and 13C NMR and mass spectrometry. The conformations adopted by the molecules were studied by DFT methods. 6 conformers were theoretically predicted for R = CH3- and (CH3)2CH-, while the conformational flexibility of the n-propyl substituent increases the total number of feasible rotamers to 21. For the three molecules, the conformers can be associated in 3 groups, being the most stable the AS forms ? the C=S double bond anti (A) with respect to the C-S single bond and the S-C single bond syn (S) with respect to the C=O double bond ? followed by AA and SS conformers. The vibrational spectra were interpreted in terms of the predicted conformational equilibrium, presenting the &#957;(C=O) spectral region signals corresponding to the three groups of conformers. A moderated pre-resonance Raman enhancement of the &#957;(C=S) vibrational mode of CH3(CH2)2OC(S)SC(O)OCH2CH3 was detected, when the excitation radiation approaches the energy of a n &#8594; &#960;&#8727; electronic transition associated with the C=S chromophore. UV?visible spectra in different solvents were measured and interpreted in terms of TD-DFT calculations. The unknown molecule CH3CH2OC(O)SH was isolated by the UV?visible photolysis of CH3OC(S)SC(O)OCH2CH3 isolated in Ar matrix, and also obtained as a side-product of the reaction between potassium xanthate salts, ROC(S)SK, and ethyl chloroformate, ClC(O)OCH2CH3.","palabras_clave":"Conformations|Vibrational spectroscopy|Photochemistry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17395,"idioma_id":4,"titulo":"Searching for line active molecules on biphasic lipid monolayers","resumen":"In membranes with phase coexistence, line tension appears as an important parameter for the  determination of the amount of domains, as well as their size and their shape, thus defining the  membrane texture. Different molecules have been proposed as ?linactants? (i.e. molecules that reduce  the line tension, thereby modulating the membrane texture). In this work, we explore the efficiency of  different molecules as linactants in monolayers with two coexisting phases of different thicknesses. We  tested the linactant ability of a molecule with chains of different saturation degrees, another molecule  with different chain lengths and a bulky molecule. In this way, we show in the same system the effect of  molecules with chains of different rigidities, with an intrinsic thickness mismatch and with a bulky  moiety, thereby analyzing different hypotheses of how a molecule may change the line tension in a  monolayer system. Both lipids with different hydrocarbon chains did not act as linactants, while only one  of the bulky molecules tested decreased the line tension in the monolayer studied. We conclude that  there are no universal rules for the structure of a molecule that enable us to predict that it will behave as  a linactant and thus, designing linactants appears to be a difficult task and a challenge for future studies.  Furthermore, in regard to the membrane texture, there was no direct influence of the line tension in the distribution of domain sizes.","palabras_clave":"LINE TENSION|LIPID MONOLAYERS|LINACTANTS|LIQUID ORDERED"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17396,"idioma_id":4,"titulo":"Three-dimensional reconstruction of corticospinal tract using one-photon confocal microscopy acquisition allows detection of axonal disruption in spinal cord injury","resumen":"The principal motor tract involved in mammalian locomotor activities is   known as the corticospinal tract (CST), which starts in the brain motor   cortex (upper motor neuron), extends its axons across the brain to   brainstem and finally reaches different regions of spinal cord,   contacting the lower motor neurons. Visualization of the CST is   essential to carry out studies in different kinds of pathologies such as   spinal cord injury or multiple sclerosis. At present, most studies of   axon structure and\/or integrity that involve histological tissue   sectioning present the problem of finding the region where the CST is   predominant. To solve this problem, one could use a novel technique to   make the tissues transparent and observe them directly without   histological sectioning. However, the disadvantage of this procedure is   the need of costly and non-conventional equipment, such as two-photon   fluorescence microscopy or ultramicroscopy to perform the image   acquisition. Here, we show that labeling the CST with FluoroRuby in the   motor cortex and then performing the clearing technique, the   z-acquisition of the entire CST in unsectioned tissue followed by   three-dimensional reconstruction can be carried out by standard   one-photon confocal microscopy, with yields similar to those obtained by   two-photon microscopy. In addition, we present an example of the   application of this method in a spinal cord injury model, where the   disruption of CST is shown at the lesion site. We proposed this method   to detect and visualize the complete corticospinal tract (CST). This   process allows us to generate a three-dimensional reconstruction using   one-photon confocal microscopy to perform the y-acquisition in an   unsectioned cleared tissue and thereby detecting axonal disruption in   spinal cord injury. CST, corticospinal tract.","palabras_clave":"corticospinal|confocal microscopy|spinal cord injury"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17397,"idioma_id":4,"titulo":"Potassium phosphite increases tolerance to UV-B in potato","resumen":"The use of biocompatible chemical compounds that enhance plant disease resistance through Induced Resistance (IR) is an innovative strategy to improve the yield and quality of crops. Phosphites (Phi), inorganic salts of phosphorous acid, are environment friendly, and have been described to induce disease control. Phi, similar to other plant inductors, are thought to be effective against different types of biotic and abiotic stress, and it is assumed that the underlying signaling pathways probably overlap and interact. The signaling pathways triggered by UV-B radiation, for instance, are known to crosstalk with other signaling routes that respond that biotic stress. In the present work, the effect of potassium phosphite (KPhi) pre-treatment on UV-B stress tolerance was evaluated in potato leaves. Plants were treated with KPhi and, after 3 days, exposed to 2 h\/day of UV-B (1.5 Watt m&#8722;2) for 0, 3 and 6 days. KPhi pre-treatment had a beneficial effect on two photosynthetic parameters, specifically chlorophyll content and expression of the psbA gene. Oxidative stress caused by UV-B was also prevented by KPhi. A decrease in the accumulation of hydrogen peroxide (H2O2) in leaves and an increase in guaiacol peroxidase (POD) and superoxide dismutase (SOD) activities were also observed. In addition, the expression levels of a gene involved in flavonoid synthesis increased in UV-B-stressed plants only when pre-treated with KPhi. Finally, accumulation of glucanases and chitinases was induced by UV-B stress and markedly potentiated by KPhi pre-treatment. Altogether, this is the first report that shows a contribution of KPhi in UV-B stress tolerance in potato plants.","palabras_clave":"PHOSPHITE|UV-B|ABIOTIC STRES|POTATO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17398,"idioma_id":4,"titulo":"POPULATION STRUCTURE AND MATURITY STAGES OF FRITILLARIA BOREALIS (APPENDICULARIA, TUNICATA): SEASONAL CYCLE IN USHUAIA BAY (BEAGLE CHANNEL)","resumen":"Fritillaria borealis is a cosmopolitan species, very frequent in sub-antarctic and antarctic waters. The objective of this paper was to analyze its sizes structure and maturity stages at two sites of Ushuaia Bay: a coastal site exposed to anthropogenic pressure (E1) and a reference site (E2) located at the external zone of the bay. Zooplankton was collected during 2012 seasonal cycle. The sampling method involved the use of a 67 &#956;m-mesh net. Appendicularians were classified in four maturity stages: I) undifferentiated gonads, II) testis and ovary differentiated, III) expanded testis, IV) discharged testis, expanded ovary. Our results showed that highest densities of F. borealis occurred in spring and summer at both sites; coinciding with high values of chlorophyll-a. Percentage of juveniles (I and II) exhibited a spatial and temporal pattern similar to that observed for chlorophyll-a values. During spring-summer, juveniles and matures (III and IV) showed a higher gonadal development than those individuals found in autumn-winter. In conclusion, the mismatching in the population structure and the pattern of densities of F. borealis between coastal and external zones would suggest the existence of two sub-populations susceptible to the influence of the anthropogenic impact in the bay.","palabras_clave":"APPENDICULARIANS|MATURITY STAGES|BEAGLE CHANNEL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17399,"idioma_id":5,"titulo":".  Producción y uso de objetos ornamentales elaborados sobre dientes de carnívoros en contextos arqueológicos del humedal del Paraná inferior","resumen":"En este trabajo se analizan una serie de piezas dentarias de carnívoros discutiendo su utilización como objetos ornamentales por las poblaciones humanas que ocuparon el sector meridional del humedal del Paraná inferior durante el Holoceno tardío. La identificación taxonómica de los distintos elementos dentarios se efectuó mediante estudios morfométricos, siendo de particular interés señalar el reconocimiento de especies que son poco frecuentes o que hasta  ahora no estaban presentes en el registro arqueológico regional como Canis familiaris y Nasua nasua. A través del análisis microscópico, logramos identificar distintos rastros o huellas de transformación y utilización de los dientes, incluso en aquellos ejemplares que a ojo desnudo no presentaban modificaciones antrópicas. En función de los resultados obtenidos se discute la obtención y uso de estos objetos como objetos ornamentales y se realizan distintas consideraciones en cuanto a su potencial valor simbólico, señalando ciertas limitaciones interpretativas que existen sobre este tópico, así como las vías analíticas y conceptos desarrollados por otros autores para abordar problemáticas similares a las aquí estudiadas.","palabras_clave":"pendientes|carnívoros|dientes|Paraná inferior"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17400,"idioma_id":4,"titulo":"Histopathological and biochemical evidence of hepatopancreatic toxicity caused by cadmium in white shrimp, Palaemonetes argentinus","resumen":"Cadmium (Cd) is one of the most common pollutants in the environment and induces a range of tissue changes or damages and organ dysfunction. The histopathological effects of Cd and lipid peroxidation (LPO) on hepatopancreas of the freshwater shrimp, Palaemonetes argentinus, were studied. Shrimp wereobtained from two lagoons with contrasting environmental quality, De los Padres (LP, impacted site) and Nahuel Rucá (NR, reference site), and were exposed to 3.06 and 12.24 mg Cd L1 for 3, 7, 10 and 15 days.The health status of both populations was also evaluated by histological analysis of control individuals.After exposure, shrimp were transferred to clean water for 28 days to evaluate the recuperation capacity of hepatopancreas. Control shrimp from NR exhibited a normal hepatopancreas structure; unlike control shrimp from LP which showed several alterations. These results were attributed to the different environmental quality of lagoons. The exposure to Cd resulted in several alterations in the histological structure of the hepatopancreas of both populations. The observed alterations included haemocytic and connective infiltrations in the intertubular space, erosioned microvilli, ripple of basal lamina, atrophied epithelium and necrosis, however, the latter was only observed in shrimp from LP. The exposure also caused an increase of LPO levels in both populations. P. argentinus was able to repair the hepatopancreas structure from the damage caused by Cd, evidenced by the histopathological results and LPO levels.Obtained results are indicating that the histological analysis of the hepatopancreas proved to be a highly sensitive method for evaluating water quality, in both environmental and laboratory conditions.","palabras_clave":"Cadmium|Sublethal toxicity| Lipid peroxidation|Histopathology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17401,"idioma_id":4,"titulo":"Responses of phytoplankton and related microbial communities to changes in the limnological conditions of shallow lakes: a short-term cross-transplant experiment","resumen":"We performed a short-term cross-transplant experiment  (72 h) using dialysis bags in two shallow lakes with contrasting regimes  (clear-vegetated and phytoplankton-turbid). We assessed the changes in the  structure of the microbial planktonic communities in response to the variations  in the limnological conditions. Important changes were observed in >2 µm-phytoplankton  composition in the two transplanted communities (from clear-vegetated to turbid  and vice versa). Cyanobacteria biomass (Snowella spp.) increased in the  transplanted treatment from the clear to the turbid lake, whereas the contribution  of Ochromonas-like sp. diminished. Colonial and filamentous Cyanobacteria  species dominated the phytoplankton of the turbid lake throughout the  experiment, both in non-transplanted and transplanted waters. Chrysophyceae  showed an increasing trend at 72 h in the transplanted treatment (from turbid to  clear waters). Heterotrophic bacteria biomass increased in the transplanted  treatment from the clear to the turbid system, probably due to a higher availability  of more labile sources of dissolved organic carbon (DOC). Our results evidenced  changes in the microbial communities in response to important regulator factors  (nutrients, light attenuation, DOC availability and top-down control at the  microbial food web) in the two contrasting regimes.","palabras_clave":"Microbial plankton|Community structure|Shallow lakes|Turbid and clear regime"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17402,"idioma_id":5,"titulo":"IDENTIFICACIÓN DE ACTORES: UNA CONTRIBUCIÓN A LA GESTIÓN DE LOS COLECTORES DE DRENAJE DE LA CIUDAD DE CIPOLLETTI (RÍO NEGRO, ARGENTINA)","resumen":"La Ciudad de Cipolletti, con aproximadamente 100.000 habitantes, está ubicada en el Alto Valle del Río Negro, en la confluencia  de los Ríos Neuquén y Limay, que dan origen al Río Negro. El sistema de riego del Alto Valle nace en el Dique  Ballester, sobre el río Neuquén y riega unas 50.000 ha, principalmente con producción frutícola (manzanas y peras). Los  colectores de drenaje del sistema de riego fueron construidos para captar excedentes de riego, controlar la posición de  la capa freática, evitar riesgos de salinización de los suelos y evacuar excedentes pluviales de las principales ciudades  del Alto Valle. Sin embargo, en la actualidad actúan además como receptores de descargas industriales y cloacales en  algunos casos con tratamientos que respetan las normas de vuelco que fija la normativa provincial y en otros casos no. A  ello se suman descargas clandestinas de efluentes sin tratamiento alguno y una gran cantidad de residuos sólidos urbanos  que provienen de los asentamientos informales ubicados en las inmediaciones de estos colectores. En este trabajo  se presentan los resultados de la identificación y caracterización de los actores clave y el análisis de su relevancia social  en el marco de la problemática ambiental descripta. Este análisis social se considera sustantivo para el diseño de una  estructura organizacional que gestione los colectores de drenaje bajo la visión de la Gestión Integrada de los Recursos  Hídricos (GIRH). Fundado en estos conceptos se propuso la creación del Consejo de los Colectores de Drenaje de la  Ciudad de Cipolletti cuya misión es definir las políticas de gestión e implementar las acciones estructurales y medidas no  estructurales necesarias para su funcionamiento sostenible. El Consejo está integrado por un Comité Ejecutivo en cuyo  ámbito se habrán de gestionar las medidas de acción que se requieran en orden a cumplir con la misión del Consejo;  un Comité de Usuarios, que constituye una estructura deliberativa en la cual los usuarios del sistema puedan llevar sus  inquietudes, establecer prioridades y elevar requerimientos al Comité Ejecutivo; y un Comité Asesor, que constituye una  estructura de consulta y apoyo a la toma de decisiones. Por último integra el Consejo una Mesa de Diálogo entendida  como un espacio de negociación y acuerdo, que adquiere relevancia en situaciones de desacuerdo o eventuales conflictos  entre los principales actores que integran el Consejo","palabras_clave":"ACTORES CLAVES|GESTION INTEGRADA|COLECTORES DE DRENAJE|ESTRUCTURA ORGANIZACIONAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17403,"idioma_id":4,"titulo":"Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies \/ ocular delivery of drugs","resumen":"Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work thebehavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA)are evaluated as pH-sensitive drug delivery systems for potential application in ophthalmic therapies. A detailed characterizationof the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis.Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug.The interaction between Rh6G and hydrogels was studied by Fourier Transform Infrared (FTIR) spectroscopy and scanningelectron microscopy (SEM). The results show that the presence of DPA in the copolymers confers pH-responsive propertiesto the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases anda porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on thecomposition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and thecopolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA\/DPA) show a normalFickian or anomalous diffusion behavior at different pH values, depending on the HEMA\/DPA ratio.","palabras_clave":"SMART POLYMERS|2-(DIISOPROYLAMINO)ETHYL METHACRYLATE|PH-SENSITIVE HYDROGELS|DRUG DELIVERY SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17404,"idioma_id":4,"titulo":"Tracking control of concentration profiles in a fed-batch bioreactor using a linear algebra methodology","resumen":"Based on a linear algebra approach, this paper aims at developing a novel control law able to track reference profiles that were previously-determined in the literature. A main advantage of the proposed strategy is that the control actions are obtained by solving a system of linear equations. The optimal controller parameters are selected through Monte Carlo Randomized Algorithm in order to minimize a proposed cost index. The controller performance is evaluated through several tests, and compared with other controller reported in the literature. Finally, a Monte Carlo Randomized Algorithm is conducted to assess the performance of the proposed controller.","palabras_clave":"Fed-batch bioreactors|Control systemdesign|Nonlinear model|Linear algebra"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17405,"idioma_id":4,"titulo":"Environmental Quality and Aquatic Invertebrate Metrics Relationships at Patagonian Wetlands Subjected to Livestock Grazing Pressures","resumen":"Livestock grazing can compromise the biotic integrity and health of wetlands, especially in remotes areas like Patagonia, which provide habitat for several endemic terrestrial and aquatic species. Understanding the effects of these land use practices on invertebrate communities can help prevent the deterioration of wetlands and provide insights for restoration. In this contribution, we assessed the responses of 36 metrics based on the structural and functional attributes of invertebrates (130 taxa) at 30 Patagonian wetlands that were subject to Different levels of livestock grazing intensity. These levels were categorized as low, medium and high based on eight features (livestock stock densities plus seven wetland measurements). Significant changes in environmental features were detected across the gradient of wetlands, mainly related to pH, conductivity, and nutrient values. Regardless of rainfall gradient, symptoms of eutrophication were remarkable at some highly disturbed sites. Seven invertebrate metrics consistently and accurately responded to livestock grazing on wetlands. All of them were negatively related to increased levels of grazing disturbance,with the number of insect families appearing as the most robust measure. Amultivariate approach (RDA) revealed that invertebrate metrics were significantly affected by environmental variables related to water quality: in particular, pH, conductivity, dissolved oxygen, nutrient concentrations, and the richness and coverage of aquatic plants. Our results suggest that the seven aforementioned metrics could be used to assess ecological quality in the arid and semi-arid wetlands of Patagonia, helping to ensure the creation ofprotected areas and their associated ecological services","palabras_clave":"WETLANDS|PATAGONIA|GRAZING|INVERTEBRATES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17406,"idioma_id":4,"titulo":"Raman spectroscopy study of the interaction of 3,5,3' -triiodo-L-thyronine with phosphatidylglycerol lipid bilayers","resumen":"A Raman spectroscopic study of anionic model membranes and their structural alterations exerted by a relatively small biomolecule, such as the hormone 3,5,3&#8242;-triiodo-L-thyronine (T3), is presented. Spectral differences between pure dipalmitoylphosphatidylglycerol (DPPG) multilamellar vesicles and DPPG-T3 mixture and between pure dilauroylphosphatidylglycerol (DLPG) and DLPG-T3 mixture were evaluated in order to determine the response of lipid membranes in gel and liquid-crystalline phases to the hormone incorporation. Density functional theory (DFT) calculations support the band analysis of the complex 1150-1050&#8201;cm&#8722;1 Raman region. Geometry optimizations and vibrational behaviors of a model charged molecule that mimics the phosphatidylglycerol lipid moiety in solvated state were taken into account for the spectral interpretation of this specific region. The anionic nature of the lipid polar head plays an important role in the interaction with the hormone, as is evidenced by the C[DOUBLE BOND]O and PO2&#8722; stretching bands. In addition, the differential penetration of T3 into the hydrophobic region of the membranes shows to be dependent on the lipid phase. The spectral data were compared with those previously obtained for zwitterionic membranes.","palabras_clave":"PHOSPHOLIPIDS|ANIONIC MEMBRANES|VIBRATIONAL ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17407,"idioma_id":4,"titulo":"Which environmental factors trigger the dominance of phytoplankton species across a moisture  gradient of shallow lakes","resumen":"We investigated nine Pampean shallow lakes (Argentina) across a moisture gradient (mean annual precipitation 1,000?500 mm), under the framework of a network project of lakemonitoring whosemain objective was to analyse the responses of ecosystems to different stressors associated with human activities. We postulate that species bloom in different shallow lakes will be determined mainly by local optical features, nutrients and salinity. We analysed the phytoplankton structure during the warm season 2012 2013, identifying those species and functional groups that proliferate in the lakes. Most lakes showed high phytoplankton biomass, except a saline lake located in the driest part of the gradient and an inorganic turbid lake. In some lakes, cyanobacteria blooms occurred in summer, persisting until autumn. Small colonial cyanobacteria and small fast-growing chlorophytes were abundant in most turbid enriched and anthropogenically impacted systems. Lowest species and functional diversity occurred in the saline lake.Multivariate analysis indicated that the phytoplankton structure was mainly defined by conductivity, transparency and variables associated with the trophic state, also reflecting the importance of the geographical  location. Our results evidenced the vulnerability of most shallow lakes in the region to water level fluctuations,  eutrophication and canalization.","palabras_clave":"Phytoplankton|Shallow lakes|Pampa plain \u0002|Algal blooms"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17408,"idioma_id":4,"titulo":"The Effect of Midazolam and Propranolol on Fear Memory Reconsolidation in Ethanol-Withdrawn Rats: Influence of D-Cycloserine","resumen":"BACKGROUND:  Withdrawal from chronic ethanol facilitates the formation of contextual fear memory and delays the onset to extinction, with its retrieval promoting an increase in ethanol consumption. Consequently, manipulations aimed to reduce these aversive memories, may be beneficial in the treatment of alcohol discontinuation symptoms. Related to this, pharmacological memory reconsolidation blockade has received greater attention due to its therapeutic potential.  METHODS:  Here, we examined the effect of post-reactivation amnestic treatments such as Midazolam (MDZ, 3 mg\/kg i.p) and Propranolol (PROP, 5 mg\/kg i.p) on contextual fear memory reconsolidation in ethanol- withdrawn (ETOH) rats. Next, we examined whether the activation of N-methyl-D-aspartate (NMDA) receptors induced by d-cycloserine (DCS, 5 mg\/kg i.p., a NMDA partial agonist) before memory reactivation can facilitate the disruptive effect of PROP and MDZ on fear memory in ETOH rats.  RESULTS:  We observed a resistance to the disruptive effect of both MDZ and PROP following memory reactivation. Although intra-basolateral amygdala (BLA; 1.25 ug\/side) and systemic PROP administration attenuated fear memory in DCS pre-treated ETOH rats, DCS\/MDZ treatment did not affect memory in these animals. Finally, a decrease of both total and surface protein expression of the &#945;1 GABAA receptor (GABAA-R) subunit in BLA was found in the ETOH rats.  CONCLUSIONS:  Ethanol withdrawal facilitated the formation of fear memory resistant to labilization post-reactivation. DCS administration promoted the disruptive effect of PROP on memory reconsolidation in ETOH rats. The resistance to MDZ´s disruptive effect on fear memory reconsolidation may be, at least in part, associated with changes in the GABAA-R composition induced by chronic ethanol administration\/withdrawal","palabras_clave":"GABA A RECEPTOR|ETHANOL WITHDRAWAL|FEAR MEMORY|RECONSOLIDATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17409,"idioma_id":4,"titulo":"Arch-based configurations in the volume ensemble of static granular systems","resumen":"We propose an alternative approach to count the microscopic static&nbsp; configurations of granular packs under gravity by considering arches. This strategy obviates the problem of filtering out configurations that are not mechanically stable, opening the way for a range of granular models to be studied via ensemble theory. Following this arch-based approach, we have obtained the exact density of states for a 2D, non-interacting rigid arch model of granular assemblies. The calculated arch size distribution and volume fluctuations show qualitative agreement with realistic simulations of tapped granular beds. We have also validated our calculations by comparing them with the analytic solution for the limiting case of a quasi-1D column of frictionless disks.","palabras_clave":"Granular Matter|Jamming and packing"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17410,"idioma_id":5,"titulo":"El conocimiento construido por los alumnos en las clases de Química","resumen":"En este artículo presentamos resultados obtenidos a partir de un estudio realizado, desde un enfoque psicosocial, con estudiantes de nivel secundario. El estudio forma parte de una investigación más amplia en la que indagamos la incidencia de las representaciones sociales de los docentes en su práctica pedagógica y en el desempeño de los estudiantes. En este trabajo analizamos las respuestas dadas por los estudiantes en una evaluación realizada al finalizar una unidad didáctica de Química orgánica, con el objetivo de examinar el conocimiento construido por los alumnos en comparación con el conocimiento científico y analizar las respuestas y las dificultades de los estudiantes en relación con la práctica docente. A partir de los resultados obtenidos, consideramos que se evidencia la importancia de la labor docente, orientada por sus representaciones sociales, en el proceso de construcción del conocimiento en el aula. De ahí la necesidad de un replanteo de la práctica docente desde el cuestionamiento de sus representaciones y sus actitudes, para favorecer la identificación de los factores que obstaculizan el aprendizaje. Esto daría lugar, en los estudiantes, a una construcción del conocimiento que permita que éste sea cada vez más próximo al conocimiento científico.","palabras_clave":"QUIMICA ORGÁNICA|EVALUACIÓN|CONOCIMIENTO CIENTÍFICO|APRENDIZAJE|REPRESENTACIONES SOCIALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17411,"idioma_id":4,"titulo":"A semiclassical condition for chaos based on Pesin theorem","resumen":"A semiclassical method to determine if the classical limit of a quantum system is chaotic or not, based on Pesin theorem, is presented. The method is applied to a phenomenological Gamow-type model and it is concluded that its classical limit is chaotic.","palabras_clave":"PESIN THEOREM|LYAPUNOV EXPONENTS|KOLMOGOROV-SINAI ENTROPY|CLASSICAL LIMIT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17412,"idioma_id":4,"titulo":"Developmental covariation of human vault and base throughout postnatal ontogeny","resumen":"In the present study, we analyzed postnatal ontogenetic integration among morphological traits of thehuman neurocranium. Particularly, the covariation between the vault and the base during postnatal lifewas assessed. Since the association between these regions may depend on the generalized change pro-duced by allometry, we tested its effect on their covariation. On a sample of adults and subadults rangingfrom 0 to 31 years, 3D coordinates of neurocranial landmarks and semilandmarks were digitized andgeometric morphometric technics were applied. Main aspects of shape variation were examined usingPrincipal Components analysis. Covariation between the vault and the base was examined by PartialLeast Squares analysis. According to our results, the vault and the base covary strongly during postnatalontogeny and their relation depends largely on allometry. Two size variables were studied: centroid size,which was obtained from the recorded morphometric points, and endocranial volume, taken as an esti-mation of brain size. Although growing brain was found to be a developmental process that contributesto covariation among neurocranial traits, there would be other factors that exert their influence duringontogeny. These results lead to reconsider cranial morphological evolution taking into account the devel-opmental constraints given by ontogenetic patterns of integration and reinforcing the idea that in humanevolution a suite of relevant characters may be fuelled by few developmental processes.","palabras_clave":"MORPHOLOGICAL INTEGRATION|NEUROCRANIAL GROWTH|PARTIAL LEAST SQUARES|MODULARITY|ALLOMETRY|GEOMETRIC MORPHOMETRICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17413,"idioma_id":5,"titulo":"Estudiando concepciones de aprendizaje  mediante la lectura en la universidad. Investigación cuasi-experimental pre-post","resumen":"Se presenta el diseño de una investigación en la que se estudia el cambio de las concepciones de aprendizaje a partir de la lectura en ingresantes universitarios, promovido mediante intervenciones instruccionales en el contexto del aula universitaria. El diseño de la investigación es tipo cuasi experimental pre - post con grupo cuasi control. Para la recolección de datos en las etapas pre y post intervención instruccional se utiliza un Cuestionario de Dilemas construido, puesto a prueba y validado para esta investigación. Los sujetos de investigación son estudiantes ingresantes a la universidad (Departamento de Ciencias de la Educación ? UNRC). Los resultados más relevantes indican que, al comparar las etapas pre y post intervención instruccional, se advierten cambios que en general muestran el avance de concepciones más simples hacia concepciones más complejas en los estudiantes. Los cambios representacionales hallados en las indagaciones realizadas con posterioridad a la intervención instruccional afectan a las condiciones y resultados de aprendizaje a partir de la lectura, en el escenario educativo de escritura; al concepto de aprendizaje a partir de la lectura, en el escenario educativo de oralidad; y al concepto, las condiciones y los resultados de aprendizaje a partir de la lectura, en el escenario educativo de evaluación.","palabras_clave":"INVESTIGACIÓN CUASI EXPERIMENTAL  PRE-POST|CONCEPCIONES|APRENDIZAJE Y LECTURA|UNIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17414,"idioma_id":4,"titulo":"Suspected natural lysosomal storage disease from ingestion of pink morning glory (Ipomoea carnea) in goats in northern Argentina","resumen":"This study describes an occurrence of pink morning glory (Ipomoea carnea) intoxication in goats in northern Argentina. Clinical signs of the affected animals were ataxia, lethargy, emaciation, hypertonia of the neck muscle, spastic paresis in the hind legs, abnormal postural reactions and death. The clinico-pathologic examination revealed that the affected animals were anemic and their serum level of aspartate aminotransferase had significant increase. Cytoplasmic vacuolation in Purkinje cells and pancreatic acinar cells were observed by histological examination. Neuronal lectin binding pattern showed a strong positive reaction to WGA (Triticum vulgaris), sWGA (succinylated T. vulgaris) and LCA (Lens culinaris). Although I. carnea is common in tropical regions, this is the first report about spontaneous poisoning in goats in Argentina.","palabras_clave":"ARGENTINA|GOATS|IPOMOEA CARNEA|NEUROTOXICITY|SPONTANEOUS POISONING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17415,"idioma_id":5,"titulo":"Evolución de la suplementación, el consumo de pastura y la producción de leche en sistemas lecheros de argentina","resumen":"Individual milk yield and pasture and supplement consumption are factors related to dairyfarm?s profitability. To investigate the evolution of milk production and supplement and pasture consumption, data of 40 dairy farms of the central region of Santa Fe were analyzed from 2004-2012. Results showed a 65% increase in the amount of consumed supplements per cow, allowing a moderate increase in the stocking rate (35%), and an increase in individual milk production (9,5%). However, pasture consumption per cow and per hectare showed a decrease for the same period.Some causes that would explain the low response in milk production per cow with high addition of supplements could be: high substitution rate, low quality of supplements, and lack of adequate infrastructure on dairy farms.","palabras_clave":"Suplementos|Produccion de leche|Sistemas lecheros|Tasa de sustitucion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17416,"idioma_id":4,"titulo":"On Sparse Methods for Array Signal Processing in the Presence of Interference","resumen":"We analyze the performance of several algorithms designed to solve the   inverse sparse problem when they are applied to array signal processing.   Specifically we study the error on the estimation of the complex   envelope and the direction of arrival of signals of interest in the   presence of interference sources using a uniform linear array. In   particular, we compare the performance of the Enhanced Sparse Bayesian   Learning (ESBL) algorithm against different algorithms tailored to this   scenario. Since the former exploits interference information to diminish   its unwanted effects, we find that it provides a reasonable tradeoff   between runtime and estimation error.","palabras_clave":"Estimation|Interference|Sensor Arrays |Sparse Models"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17417,"idioma_id":6,"titulo":"Les jeux, les enfants et les nouvelles technologies : une relation culturelle et complexe","resumen":"Les jeux et les enfants ont une relation qui peut être identifiée tout au long de l?histoire moderne. La caractéristique la plus remarquable du contexte contemporain est liée à l?apparition des nouvelles technologies et au rôle de l?industrie des jeux et des jouets comme des participants clés des jeux enfantins. C?est pour cela que nous nous proposons de composer une approche sur les différentes relations que nous avons trouvées dans nos recherches sur les enfants, les médias et les nouvelles technologies de l?information et de la communication. L?objectif de cet article est de présenter une analyse sur les jeux et les nouvelles technologies avec une hypothèse polémique. Elle soutient que les jeux pour les enfants ont beaucoup plus d?éléments de continuité que de différences, bien qu?ils soient présentés sous des supports variés et apparemment originaux. Nous avons choisi deux axes analytiques afin d?organiser cet article. Le premier s?appelle « Le domino en tant que jeu résiduel » et le deuxième aborde la relation entre les armes et les soldats dans l?histoire des jouets. Ces dimensions vont nous donner des espaces conceptuels et théoriques pour présenter une analyse sur la relation entre les jeux, les enfants, les nouvelles technologies et la culture contemporaine. On va présenter différents exemples sur chaque axe pour illustrer le fonctionnement des dynamiques, caractéristiques mais aussi des variables qu?on a trouvées dans la recherche.","palabras_clave":"juego|Pantallas|infancias|Nuevas Tecnologías"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17418,"idioma_id":5,"titulo":"Evaluación de la accesibilidad en software generado por un entorno de desarrollo integrado","resumen":"Se describe la evaluación de la accesibilidad de un producto software desarrollado con un entorno de desarrollo integrado o IDE que genera semiautomáticamente aplicaciones en  JAVA. Se detalla la metodología aplicada, los resultados obtenidos utilizando un validador automático como criterio de calidad en el desarrollo de soluciones informáticas, y se expresan las consideraciones finales.","palabras_clave":"Ingeniería del Software|Accesibilidad web|WCAG 2.0"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17419,"idioma_id":4,"titulo":"Automatic Evaluation of WCAG 2.0  Guidelines in a Drupal-based Platform","resumen":"Web accessibility has become a main concern that has motivated interest all over the world.The Web Accessibility Initiative (WAI) defines guidelines to let people with disabilities access ICT. This article presents the web accessibility evaluation applied to Drupal CMS, using guidelines WCAG 2.0, and an automatic validator.","palabras_clave":"WAI|WCAG 2.0 GUIDELINES|EVALUATION|W3C|WEB ENGINEERING|WEB QUALITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17420,"idioma_id":4,"titulo":"The Near-ultraviolet Luminosity Function of Young, Early M-type Dwarf Stars","resumen":"Planets orbiting within the close-in habitable zones of M dwarf stars will be exposed to elevated high-energy radiation driven by strong magneto-hydrodynamic dynamos during stellar youth. Near-ultraviolet (NUV) irradiation can erode and alter the chemistry of planetary atmospheres, and a quantitative description of the evolution of NUV emission from M dwarfs is needed when modeling these eects. We investigated the NUV luminosity evolution of early M-type dwarfs by cross-correlating theLepine & Gaidos (2011) catalog of bright M dwarfs with the GALEX catalog of NUV (1771{2831A) sources. Of the 4805 sources with GALEX counterparts, 797 have NUV emission signicantly (> 2:5) in excess of an empirical basal level. We inspected these candidate active stars using visible-wavelengthspectra, high-resolution adaptive optics imaging, time-series photometry, and literature searches to identify cases where the elevated NUV emission is due to unresolved background sources or stellar companions; we estimated the overall occurrence of these alse positives' as 16%. We constructed a NUV luminosity function that accounted for false positives, detection biases of the source catalogs, and GALEX upper limits. We found the NUV luminosity function to be inconsistent with predictions from a constant star-formation rate and simplied age-activity relation dened by a two-parameter power law.","palabras_clave":"binaries: close|stars: activity|stars: late-type|stars: luminosity function, mass function"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17421,"idioma_id":4,"titulo":"How to prioritize allocating conservation efforts: an alternative method tested with imperilled herpetofauna","resumen":"Several methods were developed with the aim of prioritizing conservation efforts. However, most of these methods were focused on ranking areas for land protection, without offering alternatives for sites poorly ranked. We propose an alternative method that allows prioritizing conservation efforts independently of the status of a specific area. The conservation priorities method considers data related with biodiversity, availability of suitable habitat and human pressure, on area-based units. This information is then standardized, obtaining a vector of three values, which reflects the situation of a specific area categorically (positive and negative) and quantitatively (how far from zero). Based on these values, specific conservation efforts can be settled at each area-based unit. We tested this methodology on several political units located at the Pampean Coastal Dunes in Argentina, using herpetofauna as surrogate taxon. Our results confirm the needs of performing several conservation approaches to deal with Pampean Coastal Dunes´ problems. The conservation priorities method showed to be a useful tool to characterize sites and to set conservation efforts based on its specific status, supplementing current methodologies.","palabras_clave":"conservation|index|herpetofauna"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17422,"idioma_id":4,"titulo":"Percolation of dimers irreversibly adsorbed on heterogeneous surfaces","resumen":"The percolation problem of irreversibly deposited dimers on square lattices with two kinds of sites is studied. Simple adsorptive surfaces are generated by square patches of l × l sites, which can be either arranged in a deterministic chessboard structure or in a random way. Thus, the system can be characterized by the distribution (ordered or random) of the patches, the patch size l and the probability of occupying each patch &#952; i (i = 1 , 2). Dimers (particles that occupy two neighboring sites simultaneously) are irreversibly adsorbed on the lattice. By means of random adsorption simulations and finite-size scaling analysis, acomplete ( &#952; 1 ? &#952; 2 ?l) phase diagram separating a percolating and a non-percolating region is determined.","palabras_clave":"Percolation|Dimers|Adsorption|Heterogeneous surfaces"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17423,"idioma_id":4,"titulo":"Induction of vitellogenesis by 17-hydroxyprogesterone and methyl farnesoate during post-reproductive period, in the estuarine crab Neohelice granulata","resumen":"Abstract  Adult female crabs (Neohelice granulata) were treated during the post-reproductive period with both 17-hydroxyprogesterone (17PG) and methyl farnesoate (MF). During the 4-week in vivo assay, animals were fed hormone-enriched (17PG or MF) pellets twice a week, at a dose of 2 nmol\/g of body weight. Additionally, at the middle of the in vivo experiment, ovarian explants were incubated in vitro with each hormone at a concentration of 15 &#956;M for 24 h. At the end of the in vivo assay, both the gonadosomatic index and the vitellogenic protein content (Vg) of crabs treated with either 17PG or MF were significantly higher (p  0.05). The involvement of these hormones in the regulation of ovarian growth during the reproductive cycle of N. granulata is discussed.","palabras_clave":"REPRODUCTION|17-HIDROXIPROGESTERONE|METHYL FARNESOATE|OVARY|CRABS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17424,"idioma_id":4,"titulo":"Biological  variables  as  soil  quality  indicators:  Effect  of  sampling  time and  ability  to  classify  soils  by  their  suitability","resumen":"Soil biological variables are considered good soil quality indicators due to their high sensitivity andability to reflect soil management effects. However, they frequently show high temporal variability.Our objectives were: (a) to analyze temporal stability and seasonal effect on biological variables, (b) tochoose between autumn and spring to sample for soil biological variables, and (c) to determine biologicalvariables able to discriminate among selected soil subgroups. Areas with minimal human disturbancewere sampled in three soil orders (Mollisol, Vertisol and Alfisol) during two and a half years, each autumnand spring. Microbial biomass C and N (MBC, MBN), basal respiration (Resp), metabolic quotient (qCO2),potential of N mineralization (PNM-AI), soil organic C (TOC) and total soil N (TON) were measured inthree composite soil samples collected from homogeneous areas at 0?15 cm depth. For the studied soils,selected soil biological variables presented different levels depending on the time of sampling, spring orautumn. Hence, the importance of pointing out the time of sampling to report results of these variablesin this kind of studies is remarked. In general, biological variables presented higher stability when wesampled soils in autumn compared to spring. Because of this, we used autumn soil samples to determinethe best soil biological variables to discriminate among selected subgroups of soils. The separation of soilsubgroups by means of discriminant analysis using just TOC and TON was scrutinized, considering thatthese soil variables are routinely measured in soil test laboratories. Nonetheless they were not able todiscriminate properly among soil subgroups because they showed high error rates classifying the samplesin the correct subgroups. In contrast, the variables PMN-AI, MBC, and MBN adequately discriminated thefive soil subgroups. From the biological variables, PMN-AI and MBC were the best ones to characterize(discriminate) among the five soil subgroups. Particularly, PMN-AI was able to separate soils by their suitability for agricultural purposes","palabras_clave":"Biologica indicators|Microbial biomass|Potential of N mineralization|Sampling time"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17425,"idioma_id":4,"titulo":"Ichnological research in Lower Cretaceous marginal-marine facies from Patagonia: outcrop studies, SEM examinations and paleontological\/sedimentological integration","resumen":"In-depth ichnological  studies of Lower Cretaceous, marginal-marine facies from the Agrio Formation  (Patagonia, Argentina) have been carried out during the past few years. Several  ichnofossils were identified and described for the first time in this unit,  including a new ichnospecies (Hillichnus  agrioensis) produced by tellinid bivalves, xiphosurid trackways (the first  record from the Early Cretaceous worldwide) and dinosaur tracks (one of the few  examples from Early Cretaceous carbonates in Gondwana).&nbsp; The sedimentological information showed the  presence of marginal-marine intervals previously interpreted as open marine.  The outcrop studies resulted in the finding of indirect evidence of microbial  mats, while SEM examinations resulted in the direct evidence of their presence  in certain levels; this has taphonomical implications. Both ichnological and  sedimentological results allowed to challenge previous facies model belts that  suggested permanent submerged littoral facies for this part of the basin during  the Early Cretaceous. The inferred paleoenvironment for the top of the unit is  shallower and more tidally-influenced than previously thought.","palabras_clave":"Agrio Formation|Patagonia|Trace Fossils|Ichnology|Lower Cretaceous|Xiphosurid Trackways|Dinosaur Tracks|MISS|SEM|Marginal Marine"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17426,"idioma_id":4,"titulo":"Computer-guided drug repurposing: Identification of trypanocidal activity of clofazimine, benidipine and saquinavir","resumen":"In spite of remarkable advances in the knowledge on Trypanosoma cruzi biology, no medications to treat Chagas disease have been approved in the last 40 years and almost 8 million people remain infected.Since the public sector and non-profit organizations play a significant role in the research efforts on Chagas disease, it is important to implement research strategies that promote translation of basicresearch into the clinical practice. Recent international public-private initiatives address the potential of drug repositioning (i.e. finding second or further medical uses for known-medications) which can substantially improve the success at clinical trials and the innovation in the pharmaceutical field.In this work, we present the computer-aided identification of approved drugs clofazimine, benidipine and saquinavir as potential trypanocidal compounds and test their effects at biochemical as much as cellular level on different parasite stages. According to the obtained results, we discuss biopharmaceutical, toxicological and physiopathological criteria applied to decide to move clofazimine and benidipine into preclinical phase, in an acute model of infection. The article illustrates the potential of computer-guided drug repositioning to integrate and optimize drug discovery and preclinical development; it also proposes rational rules to select which among repositioned candidates should advance to investigational drug status and offers a new insight on clofazimine and benidipine as candidate treatments for Chagas disease.","palabras_clave":"CHAGAS DISEASE|DRUG REPOSITIONING|CLOFAZIMINE|BENIDIPINE|SAQUINAVIR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17427,"idioma_id":4,"titulo":"Process Ontology Specification for Enhancing the Process Compliance of a Measurement and Evaluation Strategy","resumen":"In this paper, we specify a generic ontology for the process domain  considering the related state-of-the-art research literature. As a result, the  recently built process ontology contributes to enrich semantically the terms  for the (previously developed) measurement and evaluation domain ontology by  means of stereotypes. One of the underlying hypothesis in this research is that  the generic ontology for process can be seen as a reusable artifact which can  be used to enrich semantically not only the measurement and evaluation domain  ontology but also to other domains involved in different organizational  endeavors. For instance, for the measurement domain, now is explicit that the  measurement term has the semantic of task, the measure term has the meaning of  outcome, and the metric term has the semantic of method, from the process  terminological base standpoint. The augmented conceptual framework, i.e.  measurement and evaluation concepts plus process concepts, has also a positive  impact on the GOCAME (Goal-Oriented Context-Aware Measurement and Evaluation)  strategy capabilities since ensures terminological uniformity, consistency and  verifiability to its process and method specifications. In order to illustrate  how the augmented conceptual framework impacts on the verifiability of GOCAME  process and method specifications in addition to the consistency and  comparability of results in measurement and evaluation projects, an ICT (Information  and Communications Technology) security and risk evaluation case study is  used.","palabras_clave":"PROCESS ONTOLOGY|GENERIC ONTOLOGY|MEASUREMENT AND EVALUATION ONTOLOGY|DOMAIN ONTOLOGY|GOCAME STRATEGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17429,"idioma_id":4,"titulo":"Characterization of Slags Produced during Gold Melting Process","resumen":"In  the extractive metallurgy of gold ores the cyanidation and melting process are  generally applied. This process allows obtaining the ?dore?. The slag generated  during the melting process presents different characteristics, depending on the  mineral source and the type of flux used. The literature information on this  pyrometallurgical process at high temperature is very poor. For this reason this  paper is focused on the characterization of three synthetic slags prepared in  the laboratory. The main objective of the study is to characterize the slags in  order to: a) improve the melting process operation, b) to analyze the  environmental impact, c) to determine the possibility of slag recycled if they  present good chemical and physical properties.  © 2014 The Authors.Published by Elsevier Ltd. Selection and peer-review under responsibility of the scientific committee of SAM - CONAMET 2013. ","palabras_clave":"gold|slag|pyrometallurgy|characterization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17430,"idioma_id":4,"titulo":"Microstructural Characteristics of Mold Fluxes Associated to their Thermal Behavior","resumen":"During continuous casting process of steels, several problems can arise when an inadequate heat removal in the mold is produced. This heat extraction occurs through mold powder layers formed between the cooled mold and the solidifying steel. At operating temperatures, the mold flux forms glassy and crystalline phases that affect the heat transfer from the steel to the mold. In this paper, thermal conductivity results, obtained at 900° C, on two commercial mold powders are presented. From these essays, the interfacial thermal resistances: mold\/flux and flux\/steel were determined. On longitudinal sections of the samples taken from essays, glassy and crystalline phases were characterized. The thermal behavior of these layers is correlated with the proportion of observed phases and chemical composition of each material.  © 2014 The Authors. Published by Elsevier Ltd. Selection and peer-review under responsibility of the scientific committee of SAM - CONAMET 2013","palabras_clave":"Mold fluxes|Microstructure|Crystallization|Thermal condcutivity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17431,"idioma_id":5,"titulo":"BIODEGRADACIÓN DE HIDROCARBUROS EN FONDOS DE TANQUES DE LA INDUSTRIA PETROLERA","resumen":"Los fondos de tanques provenientes de la industria petrolera son un problema ambiental a resolver en la cuencadel golfo San Jorge. En este trabajo se estudio la biodegradación del hidrocarburo remanente que queda enel sedimento después del lavado con agua y detergente del fondo de tanque. Se realizaron bioreactores alos cuales se los siguió con el sistema OxiTop, consumo de oxígeno, se realizaron recuentos bacterianos ydeterminación de hidrocarburos por infrarrojo (IR) y por cromatografía gaseosa (GC). El sedimento provenientedel lavado de fondo de tanque contenía cantidad suficiente de bacterias degradadoras y aerobias totales,con un predominio de los géneros Pseudomonas sp y Rhodococcus sp que junto a las condiciones de 20 %humedad, oxigenación y nutrientes en una proporción de 100:3:03 redujeron los hidrocarburos de 2,9 a 0,4%. La degradación se produjo mayoritariamente entre los hidrocarburos alifáticos de cadena entre 13 a 26átomos de carbono, la fracción aromáticas presentó baja degradación.","palabras_clave":"fondos de tanques|biorremediación"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17432,"idioma_id":5,"titulo":"Poblaciones bacterianas del agua de formación","resumen":"La corrosión bacteriana causa perdidas económicas y ambientales en la industria petrolera. El agua de formación posee alta conductividad, pero a pesar de esto soporta el desarrolla de algunos tipos de bacterias. El objetivo de este trabajo fue estudiar las poblaciones bacterianas aerobias y anaerobias presentes en sistemas de recuperación secundaria principalmente las bacterias asiladas que respiran Fe(III), y conocer su adaptabilidad a diferentes aceptores y dadores de electrones. Se tomaron muestras de tanque cortador, tanque skimer y de agua sin purgar del tanque skimer. Se sembró la muestran en medios con diferentes aceptores finales de electrones y con gasoil y benzoato, también en R2A. El agua de formación presentó gran biodiversidad bacteriana con  desarrollo en los diferentes medios con aceptores de electrones y gasoil y benzoato como fuente de carbono y energía. Estos microorganismos son capaces de utilizar como fuente de energía no sólo compuestos orgánicos convencionales sino también gasoil y benzoato utilizando como aceptores finales de electrones al NO3-, SO4= y Fe3+. Las cepas bacterianas aisladas fueron bacilos Gram negativos que presentaron capsula lo que facilita su adhesión a los metales","palabras_clave":"BSR|bacterias que respiran Fe|agua de formación"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17433,"idioma_id":4,"titulo":"Monitoring trace elements in Silverside (Odontesthes bonariensis) Organs from pampasic ponds, Argentina","resumen":"The presence of trace elements (Cr, Mn and Zn) in soft tissues (muscle, gills, scales, liver and gonads) of silverside (Odontesthes bonariensis), and its relation to the concentration of these elements, in water of the Pampasic ponds was studied. Based on the results, the risk of poisoning by consumption of silverside fish was calculated.Cr had a higher concentration in the fish scales of most ponds, being the gill the secondary target organ. The highest concentrations of manganese were found in gills, liver and fish scales. Gills and liver samples from Chascomús ponds had higher values &#8203;&#8203;of that metal than the rest of the ponds. In the ponds of Adela, Chis-Chis, and Barrancas these concentrations were lower, 14-34 ug\/g in gills and 5-9 ug\/g liver. In Tablilla ponds, Mn concentration in all organs of silverside was very variable. Zn was the metal in highest concentration in all the fish organs analyzed respect the other trace elements studied. Considering the limits set by the Scientific Committe on Food (SCF), Cr of 0.03 mg\/kg, 0.07 mg Mn\/kg and 1.57 mg and Zn\/ kg, and given a balanced diet, with a consumption of twice a week, we could observe that in none of the cases the consumption of this species can be harmful to human health.                                   ","palabras_clave":"silverside, |trace elements| organs|pampasic ponds"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17434,"idioma_id":4,"titulo":"Geochemical mechanisms controlling the chemical composition of groundwater and surface water in the southwest of the Pampean plain (Argentina)","resumen":"        The Pampean plain, Argentina, is one of the largest regions in the world, characterized by shallow lakes. These lakes are of various origins associated with climate changes at the end of the Quaternary, but without lakes as predecessors Groundwater discharge maintain the base flow of the lakes. The water bodies located in the southwest of the plain have been poorly studied and show some differences from the typical Pampean shallow lakes. The aim of the present research was to determine the geochemical processes that explain surface water composition and its relationship with groundwater from the Chasicó locality. Samples were collected in 2010 and 2011 from the Chasicó Lake and Chasicó Stream (surface water), and in the Chasicó locality (groundwater). Water temperature and pH were measured in situ with a pH meter. The concentration of major ions was determined by standard methods. Cation-anion composition of groundwater and surface water was plotted on a Piper´s trilinear diagram, which showed that the former is of the sodium bicarbonate type, while the latter is of the sodium chloride type. On the other hand, Ca2+ + Mg2+ - (SO4- + HCO3- + CO3-) was plotted against Na+-Cl- for groundwater. A good correlation was found between them (R2=0.99), with a slope (p=-1.03) indicating a cationic exchange process between Ca2+ and Na+. The ionic composition of surface water differed from that of groundwater, which may be associated with climatic factors such as the precipitation and crystallization-evaporation processes. This difference in chemical composition suggests that groundwater is not the main source of water of the Chasicó Lake.","palabras_clave":"Geochemical processes; | groundwater; |surface water| Chasicó Lake"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17435,"idioma_id":4,"titulo":"Use of lapillus otolith microchemistry as an indicator of the habitat of Genidens barbus from different estuarine environments in the southwestern Atlantic Ocean","resumen":"The marine catfish Genidens barbus is an anadromous species from South America. The aim ofthe present study was to evaluate the use of lapillus otolith microchemistry (Sr:Ca; Ba:Ca and Mg:Ca ratios) as an indicator of changes in habitat use and identify the potential breeding areas and fish stocks of G. barbus populations from the Plata Basin (Paraná River Delta and De la Plata River estuary-Argentina) and Lagoa dos Patos coastal lagoon (southern Brazil). Sr:Ca, Ba:Ca andMg:Ca ratios were measured in the core area (inner 4 rings) and external area (outer 3?4 rings) of the otoliths by ICP-OES. The Sr:Ca ratio tended to be higher in the otolith external area than in the core area, while the Ba:Ca ratio followed the opposite pattern. This suggests the displacement of fish toward higher salinity areas. The Sr:Ca, Ba:Ca, Mg:Ca ratios in the core and external areas of the otoliths from the Plata Basin differed significantly from those of the otoliths from Lagoa dos Patos. This may indicate the occurrence of two different breeding sites and at least two fish stocks in the study region.","palabras_clave":"Anadromous, |Genidens barbus, .| Lapillus otolith, |. Microchemistry, ."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17436,"idioma_id":4,"titulo":"A simple Streptomyces spore-based impedimetric biosensor to detect lindane pesticide","resumen":"tLindane is a pesticide potentially harmful to environment and human health and in general, its detectioninvolves mostly tedious, expensive and time-consuming techniques. A new strategy to detect lindanecan be focused on the activity of Streptomyces strain M7 (SM7), which is capable to grow in the presenceof organochlorine pesticides (OCPs) as carbon source. On this regard, the aim of this work is to present anoptimized design of a microbial biosensor prototype based on a SM7 spore platform to detect and quantifylindane by electrochemical impedance spectroscopy (EIS) as the transduction method. By means of thistechnique, the metabolic bacterial activity was evaluated by analyzing a set of electrical parameterscalculated by fitting the measured impedance spectra through an equivalent electrical circuit. Activitystudies were performed by incubating the SM7 spore platform with (optimized incubation conditions)and without (to be used in a practical biosensor) shaking in the presence of lindane. In all cases, bacterialactivity was measured by the impedance changes produced in the cells due to lindane removal from theculture medium. This proposed label-free impedimetric biosensor is simple, cost-effective and feasibleto detect changes in the lindane concentration as low as 120 g L&#8722;1in less than 2 days without samplepretreatment. In addition, the surface of electrodes can be reused for several different tests. This sensorprototype represents a valuable alternative for OCPs detection.","palabras_clave":"Impedimetric biosensor|Spore-based platform|Impedance spectroscopy|Streptomyces"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17437,"idioma_id":4,"titulo":"Polysaccharides from the green seaweed Codium decorticatum. Structure and cell wall distribution","resumen":"The cell wall polysaccharides from Codium decorticatum and their assembly were studied and these resultswere compared with those obtained previously for this genus. The water soluble polysaccharides are:(i) Pyruvylated and sulfated 3- and 6-linked -d?galactans with sulfate mainly on C-4 and also on C-6.Pyruvate ketals are linked to O-3 and O-4 of terminal -d-galactose or O-4 and O-6 of 3-linked -d-galactose. (ii) Sulfated 3-linked -l-arabinans substituted on C-2 or C-2 and C-4 predominantly withsulfate, but also with single stubs of arabinose, and (iii) 4-linked -d-mannans with a low degree ofsulfation on C-2. The whole polysaccharide system comprises 6.9% of sulfated polysaccharides and 32.9%of fibrillar polysaccharides, mostly insoluble mannans. By in situ localization it was possible to detect twosimilar fibrillar layers separated by a zone rich in charged polymers. Besides, arabinogalactan proteinsco-localized with the fibrillar components.","palabras_clave":"Sulfated polysaccharide|Polysaccharide structure|Cell wall|Green seaweed|Codium"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17438,"idioma_id":4,"titulo":"STRUCTURAL AND CHEMICAL CHARACTERIZATION OF THE XYLEM OF THREE BLECHNUM ARBORESCENT SPECIES","resumen":"This contribution provides a detailed study of the xylem in three arborescent species of  Blechnum section Lomariocycas using SEM, TEM, FT-IR spectroscopy and sugar  composition analysis. The overall structure of root and rhizome metaxylem tracheids  was similar in all species analyzed, with various facets and mostly scalariform pitting.  Pit membrane thickness and porosity varied according to the tracheid stage of  maturation. Approximately rounded deposits resembling vestures were observed in the  outer pit apertures of some tracheids. Under TEM, thickenings like one-sided tori  appeared on the tracheid side of tracheid to parenchyma blind pits; some parenchyma  cells showed, in addition, features of transfer cells. As the increase in stature creates  new constraints in terms of biomechanical support and water transport in plants, the  characteristics found in Blechnum xylem might be related to an improvement in the  flow of water and to the prevention of embolism. Chemical analyses of roots and  rhizomes of B. yungense revealed similar levels of G-type lignin deposited in the xylem  cell walls. Such lignin is the most common in ferns, including other arborescent genera.  Preliminary analysis of cell wall polysaccharide composition suggested that both root  and rhizome xylem, consists of cellulose, xyloglucans and xylans with low amounts of  mannans and pectins. Higher amount of cellulose was detected in the xylem of rhizomes  compared to that of the roots. This information is discussed in the context of functional  and evolutionary aspects of xylem tissue in ferns.","palabras_clave":"Blechnum|arborescent ferns|tracheids"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17439,"idioma_id":4,"titulo":"The ichnogenus Dictyodora from Late Silurian deposits of central-western Argentina: ichnotaxonomy, ethology and ichnostratigrapical perspectives from Gondwana","resumen":"      The association  of trace fossils from the Late Silurian Río Seco de los Castaños Formation in  central-western Argentina (San Rafael Block) is mainly composed of Dictyodora, including D. scotica, D. tenuis and a new ichnospecies named D. atuelica. The latter shows a tendency to migrate to a deeper level  ? analogous to D. liebeana?s ? which  reflects more sophisticated behavioural patterns. The Dictyodora ichnospecies (one of the most diverse assemblages in  Gondwana) coexists with Nereites. SEM observations and EDS  analyses suggest that the wall structure of Dictyodora  could be the result of an activity other than the traditional suggestion of respiration,  e.g., feeding. The succession, including some of the levels containing Dictyodora, presents microbially induced  sedimentary structures (MISS) that would indicate a photic zone. This discovery  favours previous deltaic interpretations instead of the deep-sea fan deposits historically  suggested for the Siluro-Devonian greywackes of the Cuyania terrane, and  particularly for this unit. The abundant Dictyodora,  Nereites, Zoophycos and undermat miners ichnofossils, as well as the scarce  arthropod trackways, resemble older records in Europe and North America. The  studied section is very well age-constrained, and the autochthonous Gondwana  ichnofauna permits to cast doubt on previous interpretations, suggesting that  after the Ordovician, microbial mats retreated to marginal marine environments  and then spread later in the Carboniferous. More importantly, the occurrence of  Dictyodora and Nereites in beds that bear abundant wrinkle structures or records  of biofilms in some places is challenging with regard to deep-sea  interpretations. Dictyodora   is  probably not a good stratigraphic indicator, and the provincialism   suggested  for this ichnogenus may be an artefact of the lack of more   complete records in  Gondwana.    ","palabras_clave":"Central-western Argentina|Trace fossils|Dictyodora|Silurian"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17440,"idioma_id":5,"titulo":"Análisis de un programa de selección de larga duración en una línea maternal de conejos","resumen":"En las líneas maternas de conejos el principal objetivo es incrementar el tamaño de camada, siendo los criterios más empleados el tamaño de camada al nacimiento y al destete. Estos caracteres son de baja heredabilidad y por lo tanto, la mejora genética de las líneas maternas requiere de un trabajo a largo plazo y de la aplicación de métodos de predicción de valores genéticos apropiados. En el presente trabajo se describen y analizan los resultados de un programa de selección de larga duración por caracteres reproductivos en una línea maternal de conejos. Los mismos indican que luego de 37 generaciones de selección se ha mejorado sustancialmente caracteres tales como el número de gazapos nacidos y destetados.","palabras_clave":"Conejos|Gazapos destetados|Respuesta a la selección"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17441,"idioma_id":5,"titulo":"Estudio sobre la relación entre el nivel educativo de la madre y el rendimiento cognitivo infanto-juvenil a partir del WISC-IV","resumen":"Este trabajo de investigación tiene como objetivo explorar la relación entre el desempeño intelectual y el nivel educativo materno. Se tomaron muestras de 50 parejas madre-hijo. Para evaluar el rendimiento cognitivo de los niños, se utilizaron la escala Wechsler (4ª edición (WISC-IV) y un cuestionario demográfico de educación materna. Los resultados mostraron correlaciones significativas entre las dos variables. En consecuencia, la educación materna fue un factor de predicción relevante en WISC-IV se confirma la escala. Las conclusiones también demuestran la necesidad de reconocer los factores socioambientales en torno a este tema para desarrollar una interpretación más completa relacionada con los resultados de las pruebas.","palabras_clave":"nivel educativo materno|WISC-IV|infancia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17442,"idioma_id":5,"titulo":"Avances en la caracterizacion zootecnica de la raza ovina criolla argentina","resumen":"La raza ovina Criolla Argentina,  fundadora de la producción ovina nacional,  cumple actualmente una función muy destacada para el desarrollo local de distintas regiones argentinas. El estudio de sus características zootécnicas ha comenzado recientemente y  aún  falta  mucho  por  hacer.  El  aporte  del  trabajo  consiste  en  estudiar  cuatro poblaciones  de  ovinos  criollos  ubicadas  en  distintas  provincias:  Salta,  Corrientes, Santiago del Estero y Buenos Aires, considerando trece variables zoométricas y cinco variables indicadoras de la calidad de la lana. Los resultados revelan una importantediversidad morfológica y que en ninguna de las regiones estudiadas la lana puede ser clasificada como ?carpet wool? o lana de alfombras. Es necesario ampliar los estudios sobre  este  valioso  recurso  zoogenético  local   para  poder  optimizar  su aprovechamiento.","palabras_clave":"Ovinos |Criollos |Zootecnia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17443,"idioma_id":4,"titulo":".  ?Urban policy and gentrification process:  studying socio-territorial changes in the southern area of the City of Buenos Aires?","resumen":"The processes of urban renewal and regeneration have played an important role in the transformation of the city of Buenos Aires during the last few decades. The model of economic liberalization in the mid-seventies laid the foundations of a new urban order sustained by the development of real-estate investments, dynamized commerce, the supply of cultural and recreational services, etc., which promoted the modernization of the city. This dynamic has had a considerable impact on the southern neighbourhoods, creating the conditions for the displacement of the lower-income sectors which have historically resided there.   We understand gentrification as the result or effect, of different scope and characteristics, of the dynamic of urban restructuring in capitalist society: improvement in the built environment, changes in the composition of the population (those with higher incomes, not necessarily owners, sometimes consumers), presence of new commercial and touristic investments, with distinctive aesthetics.  We are therefore interested on the one hand in explaining the conditions of development of the common features present in these dynamics which define the general framework that enables the unfolding of the gentrification processes. To this end, our investigation has demonstrated for the case of Buenos Aires the importance of the role played by urban public policies, particularly investment decisions and changes in regulations. The state has had a key role as a promoter, attracting corporate actions regarding the different neighbourhood environments. Even in that context, however, it is possible to observe that the instruments used to operationalize the processes of renewal and regeneration vary in the different contexts.   This article, which presents the results of research into four neighbourhoods of the southern area where the changes are really evident - San Telmo, La Boca, Barracas and Parque Patricios - makes a significant contribution to the understanding of the particular characteristics assumed by the processes of gentrification guided by the state (Lees and Ley, 2008) and their scope, limitations and contradictions.  Indeed, we have seen that there is no single model of gentrification that would allow us to understand the different dynamics that coexist in the city of Buenos Aires. In particular, the effects of the government interventions in each neighbourhood create different dynamics and resistance processes that also interact with public policies, producing new institutional answers that leave their mark on the neighbourhoods. In this sense, our analysis has recognized the presence of social housing development projects launched as the result of the demands made by social organizations and inhabitants who claim their right to live in the neighbourhood. These initiatives have developed concurrently with the processes of gentrification. The housing complexes for low-income families built in the four neighbourhoods on the initiative of several social organizations and cooperatives, under Law 341,  represent the active organized resistance of the population and are a clear expression of this dynamic, giving it a particular and distinctive character in the context of the last gentrification wave in comparison with other cities, in which these cycles of resistance have declined (Lees and Law, 2008).","palabras_clave":"Urban renewal|Urban policy|Social organizations|gentrytication"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17444,"idioma_id":4,"titulo":"POLYMERIC MICROPARTICLES CONTAINING INDOMETHACIN FOR INHALATORY ADMINISTRATION","resumen":"Indomethacin (IN) is a non-steroidal antiinflammatory drug. It reduces pain and inflammation in rheumatoid arthritis but its use is associated with high incidence of undesirable gastrointestinal side effects. In addition, its low solubility in water limits its oral bioavailability.  In this work, microparticles based on an IN-polylysine (PL) complex were obtained by spray drying. The system is intended to deliver the drug through the inhalatory route for both local and systemic treatments. Several formulations, varying the relative composition IN\/PLdextrine  (DX) and the total solid content of the feed solutions, were tested. The process performance (yield, air outlet temperature), product properties (IN load efficiency, moisture content, crystallinity, glass transition temperature, density, morphology and particle size distribution), the IN- polylysine ionic interaction (assessed by FT-infrared spectroscopy,  powder X-ray diffraction and thermal analysis), and in vitro IN release were studied. Powders exhibited high load efficiencies and low moisture contents, and remained in the amorphous state after nine months of storage. The particle systems with 50 % of the polylysine amino groups neutralized by IN were the more attractive ones for pulmonary treatment, since they were easily processed using a homogeneous aqueous feed, had relatively high IN contents and high cumulative fraction of respirable particles.","palabras_clave":"Polyelectrolyte-drug complexes|pulmonary route|non-steroidal antiinflammatory drug|spray drying"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17445,"idioma_id":4,"titulo":"Soil physical quality of Mollisols quantified by a global index","resumen":"Indicators synthesizing the state of the structural quality and the function of the porous system are useful for assessing soil production capacity as well as the way it may serve natural ecosystems. This research aimed (i) to determine indicators of the state and function of the porous system, (ii) to use them to derive a global index to characterize the soil physical quality, and iii) to establish a reference pore-size distribution curve for Mollisols from the province of Santa Fe (Argentina). Sixty water retention curves (WRC) of A and B horizons of Mollisols, with clay varying between 119 and 538 g kg&#8722;1, organic matter between 5 and 40 g kg&#8722;1, and soil bulk density between 1.09 and 1.49 Mg m&#8722;3, were used. The indicators measured were: pore size distribution, macroporosity (PORp), air capacity (ACt) and plant-available water capacity (PAWC) among others. Soils were classified into four groups according to their physical properties and a reference WRC was determined. From this WRC and considering a total porosity of 0.514 m3 m&#8722;3, PORp was 0.035 m3 m&#8722;3, ACt 0.153 m3 m&#8722;3, field capacity 0.361 m3 m&#8722;3, permanent wilting point 0.136 m3 m&#8722;3 and PAWC 0.225 m3 m&#8722;3. Both the high silt content and low organic matter content confer on the soil characteristics with low stability, excess of small pores and low porosity of the macropore domain. Consequently, the capacity to quickly drain the water excess and allow root proliferation was not optimal, possibly due to the high silt or clay content and the low sand content, characteristic of the soil matrix of these Mollisols.","palabras_clave":"WATER RELEASE CURVE|SILTY-LOAM|MACROPORE|SOIL MANAGEMENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17446,"idioma_id":4,"titulo":"Isolation and characterization of an Aspartic Protease from Salpichroa origanifolia Fruits","resumen":"In the present work, we purified an aspartic protease (salpichroin) from ripe fruits of Salpichroa origanifolia (Solanaceae) by means of a simple purification procedure that combined precipitation with organic solvents and anion-exchange chromatography on Mono Q, with 32.1% recovery and 13.4-fold purification. SDS-PAGE and zymograms of this enzyme showed a single band of approximately 32 kDa. The biochemical and kinetic characterization of the pure enzyme showed an acidic behavior with an optimal pH value around 3.0 -4.5 with hemoglobin and 5.5-6.0 with casein. Salpichroin activity was inhibited by pepstatin but not by phenylmethylsulfonyl fluoride, E-64, EDTA or 1,10-phenanthroline, thus suggesting an aspartic protease behavior. Salpichroin hydrolyzed natural substrates such as casein and hemoglobin with high specific activity. Kinetic studies conducted with the synthetic peptide H-Pro-Thr-Glu-Phe-p-(NO2)-Phe-Arg-Leu:OH showed lower affinity (Km 494 µM) than other representative APs. By investigating the cleavage of oxidized insulin &#946;-chain to establish the hydrolytic specificity of salpichroin, we found six cleavage sites on the substrate of peptide bonds similar to those of chymosin. PMF-MALDI-TOF\/MS and MALDI-TOF-TOF\/MS-MS were performed and the comparison between the tryptic maps and the sequences obtained for salpichroin and those deposited in databases using the MASCOT tool showed that the isolated protease matched with other plant proteases that belong to the A1 aspartic protease family. This is the first report concerning the analysis of the aspartic protease isolated from Salpichroa origanifolia fruits by biochemical and proteomic tools.","palabras_clave":"CASEINOLYTIC ACTIVITY|SALPICHROA ORIGANIFOLIA|PLANT ASPARTIC PROTEASE|PEPTIDE FINGERPRINTING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17447,"idioma_id":4,"titulo":"Biochemical biomarkers of sublethal effects in Rhinella arenarum late gastrula exposed to the organophosphate chlorpyrifos","resumen":"We determined the biochemical and molecular effects of the organophosphate insecticide chlorpyrifos (CPF) in the late gastrula embryonic stage of the South American toad Rhinella arenarum continuously exposed from fertilization (24&#8201;h). Our objective was to evaluate these responses as potential biomarkers at low, sublethal levels of the toxicant. We first established the EC50 for embryo arrest in 21.3&#8201;mg\/L, with a LOEC of 16&#8201;mg\/L. At 4&#8201;mg\/L CPF, some embryos were unable to complete the dorsal lip of the blastopore and the yolk plug became blur, probably because of abnormal cell migration. Acetylcholinesterase activity, the specific biomarker for organophosphates, was unaffected by any of the tested concentrations of CPF (2-14&#8201;mg\/L). In turn, 2&#8201;mg\/L CPF increased the reduced glutathione levels and inhibited glutathione-S-transferase activity, suggesting an oxidative stress and antioxidant response. Catalase was induced by CPF exposure at higher concentrations (8 and 14&#8201;mg\/L). We also studied transcription factor c-Fos as a signaling event related to development in early embryogenesis. Analysis of nuclear c-Fos protein showed two bands, both enhanced in embryos exposed to 2 and 8&#8201;mg\/L CPF. While nuclear Erk protein was practically unaffected, Mek protein levels were induced by the OP. Transcription factor c-Fos may be then linking oxidative stress with developmental alterations observed due to CPF exposure. These molecular and biochemical responses observed in R.&#8201;arenarum gastrula at sublethal CPF exposures may replace non-responsive AChE as very early biomarkers in toad gastrula.","palabras_clave":"AGROCHEMICALS |AMPHIBIAN|BIOMARKERS|OXIDATIVE STRESS|TERATOGENESIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17448,"idioma_id":4,"titulo":"REPRODUCTIVE PERFORMANCE OF EWE LAMBS IN NON-BREEDING SEASON EXPOSED TO hCG AT DAY 12 POST MATING","resumen":"The objective of this experiment was to determine the effect of hCG treatment at day 12post mating on ovarian characteristics, reproductive performance and conceptus growth inewe lambs induced estrus during the non-breeding season. Corriedale ewe lambs 8 monthsold were pretreated with progestagen sponges for 10 days and 300 IU of eCG. At day 12 postmating, females were treated with either physiological saline (hCG-0; n: 53) or 300 IU ofhCG (hCG-300; n: 50). Plasma progesterone concentrations were measured at day 17 postmating by radioimmunoassay. Pregnancy was monitored by transrectal ultrasonography onday 40 post mating. At day 41 post mating, 10 ewe lambs of the hCG-0 group and 9 of thehCG-300 group with single pregnancy (randomly chosen) were euthanized and subjectedto a morphometric analysis of ovary, uterine and fetal structures. Plasma progesteronelevels in the hCG-300 group were significantly higher than those in the control ewe lambs(P  0.05). Thelength of pregnant horn in ewe lambs of the hCG-300 group showed a tendency to be greatercompared with that of the hCG-0 group (P = 0.08). Differences were not detected betweengroups for the uterine weight, number of caruncles and chorionic sac length (P > 0.05).Administration of hCG at day 12 post mating increased cranium-caudal length. However,no difference was observed in biparietal diameter and fetal weight between control and hCGtreated ewe lambs. Results indicate that hCG treatment did not improve pregnancy rate,prolificacy or fetal weight, however the increase in the plasma progesterone concentrationand the percentage of multiple ovulations observed in ewe lambs during the non-breedingseason suggest a positive action of this hormone on reproductive performance","palabras_clave":"SHEEP|PROGESTERONE|MULTIPLE OVULATION|PREGNANCY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17449,"idioma_id":4,"titulo":"Nanotubes for charge storage - towards an atomistic model","resumen":"We examine the insertion of alkali and halide ions into narrow nanotubes of graphite and gold by density functional theory (DFT). For tubes with diameters less than about 10 A the optimum position of the ion is in the center of the tube. Bader analysis and an analysis of the densities of states gave contradictory results for the charge on the halide ions, but we argue on physical grounds that they carry unit negative charge. We have calculated the energies of inserting the atoms into the tubes, where they are ionized. Because of the small system size the work function of the tubes changes during this process, which makes it difficult to interpret these energies. The surrounding tubes screen the ionic charge very effectively; thereby the ion - ion interactions are strongly reduced, which explains, why narrow tubes store charge more effectively than wider one. These effects are stronger for gold than for graphite tubes. We define an effective image radius of a cylindrical tube, and calculate the image energy experienced by the ions.","palabras_clave":"NANOTUBES|CHARGE STORAGE|DFT|IMAGE CHARGE|SCREENING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17450,"idioma_id":5,"titulo":"Biomasa de Cornops aquaticum (Orthoptera: Acrididae) en humedales del nordeste de Argentina","resumen":"La estimación de la biomasa en las poblaciones de insectos, es un factor clave para cuantificar los recursos disponibles y los flujos de energía en las redes tróficas de los ecosistemas. Cornops aquaticum es un herbívoro común en las plantas de Eichhornia en los humedales del nordeste de Argentina. Nuestro objetivo fue analizar la variación de su biomasa en relación a las distintascategorías de edades de la población de este acridio, en dos plantas huésped: Eichhornia azurea y Eichhornia crassipes. Para ello, se realizaron muestreos estándar de las poblaciones de C. aquaticum con una red entomológica de 70cm de diámetro, en dos humedales con E. azurea y E. crassipes en las provincias de Corrientes y Chaco; además, se obtuvo el peso seco de los individuos (de manera directa e indirecta) y, se propuso un modelo de regresión para estimar la biomasa de C. aquaticum de manera indirecta a partir de una medida de dimensión lineal (longitud del fémur posterior). Un total de 2 307 individuos fueronrecolectados y separados en distintas categorías de edades; se obtuvo su abundancia y distintas medidas de dimensión lineal. El modelo propuesto fue lnPS=lna+b*lnH (donde PS=peso seco, a y b son constantes y H=longitud del fémurposterior) (R2=0.97). Las variaciones en la biomasa de las poblaciones de C. aquaticum se debieron a la abundancia relativa de cada categoría de edad y al peso seco individual de estos acridios. No hubo diferencias significativas entrela biomasa de las poblaciones de C. aquaticum obtenida por los métodos directo e indirecto en las praderas flotantes de E. azurea y E. crassipes. Este modelo facilita el cálculo de la biomasa individual y poblacional de C. aquaticum yacelera el procesamiento de un gran número de muestras. Finalmente, los valores altos de biomasa poblacional e individual de las categorías de edades (especialmente en adultos) enfatizan la importancia de C. aquaticum como consumidor y como recurso para los depredadores en las redes alimenticias de las praderas flotantes de Eichhornia.","palabras_clave":"PESO SECO|EICHHORNIA|FÉMUR|ACRIDIO SEMIACUÁTICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17451,"idioma_id":4,"titulo":"Sex ratios in juveniles and adults of Dichroplus maculipennis and Borellia bruneri (Orthoptera: Acrididae)","resumen":"Dichroplus maculipennis and Borellia bruneri are two of the 18 grasshopper species of actual or potential economic relevance as pests in Argentina. The objective of this study was to estimate the sex ratios for adults and older nymphs of D. maculipennis and B. bruneri in the field, and analyze possible temporal variations. The study was conducted during seven seasons (2005-06 to 2011-12) in representative plant communities of the southern Pampas region. A total of 4536 individuals of D. maculipennis, and 6038 individuals of B. bruneri were collected. The sex ratio registered in older nymphs for D. maculipennis and  B. bruneri did not deviate from a 1:1 ratio (p > 0.05), suggesting that these species have such a primary sex ratio. However, a significant bias in sex composition in adults of both species was observed (p < 0.05). The sex ratio in adults of D. maculipennis was different in five of the 18 sampling dates carried out. In three sampling dates it was biased toward males, while in the other two it was biased toward females. Taking into account the sex ratio by sampling season, significant differences were recorded in two seasons. In 2007-08 the sex ratio was biased toward males (1 F:2.26 M), while in 2008-09 it was biased toward females (1.35 F:1 M). The sex ratio in adults of B. bruneri was always biased toward males (p < 0.05). We conclude that results obtained in this study indicate that various factors like differential survival,dispersion, predation, among others, could have modified the primary sex ratio in these species.","palabras_clave":"ACRIDIDAE|ADULTS|NYMPHS|PAMPAS REGION|SEX RATIO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17452,"idioma_id":4,"titulo":"Optimal Design for Parameter Estimation in EEG Problems in a  3D Multilayered Domain","resumen":"            The fundamental problem of collecting data in the est way' in order to assure statistically efficient estimation of parameters is known as Optimal Experimental Design. Many inverse problems consist in selecting best parameter values of a given mathematical model based on ts to measured data. These are usually formulated as optimization problems and the accuracy of their solutions depends not only on the chosen optimization scheme but also on the given data. We consider an electromagnetic interrogation problem, specifically those arising in an electroencephalography (EEG) problem,of finding optimal number and locations for sensors for source identication in a 3D unit sphere from data on its boundary. In this effort we compare the use of the classical D-optimal criterion for observation points as opposed to that for a uniform observation mesh. We consider location and best number of sensors and report results based on statistical uncertainty analysis of the resulting estimated parameters.          ","palabras_clave":"ELECTROMAGNETIC INVERSE PROBLEMS|OPTIMAL DESIGN IN 3D|EEG ANALYSIS|PARAMETER ESTIMATION|ASYMPTOTIC ERROR ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17453,"idioma_id":4,"titulo":"Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass","resumen":"In regenerative medicine of vascularized tissues, there is a great interest in the use of biomaterials that are able to stimulate angiogenesis, a process necessary for rapid revascularization to allow the transport and exchange of oxygen, nutrients, growth factors and cells that take part in tissue repair and\/or regeneration. An increasing number of publications have shown that bioactive glasses stimulate angiogenesis. Because it has been established that boron (B) may play a role in angiogenesis, the aim of this study was to assess the in vivo angiogenic effects of the ionic dissolution products that from a bioactive glass (BG) in the 45S5 system doped with 2 wt% B2O3 (45S5.2B). The pro-angiogenic capacity of 45S5.2B BG was assessed on the vasculature of the embryonic quail chorioallantoic membrane (CAM). Ionic dissolution products from 45S5.2B BG increased angiogenesis. This is quantitatively evidenced by the greater expression of integrin avb3 and higher vascular density in the embryonic quail CAM. The response observed at 2 and 5 days post-treatment was equivalent to that achieved by applying 10 mg mL_1 of basic fibroblast growth factor. These results show that the ionic dissolution products released from the bioactive glass 45S5.2B stimulate angiogenesis in vivo. The effects observed are attributed to the presence the ionic dissolution products, which contained 160 _ 10 mM borate","palabras_clave":"BIOACTIVE GLASS|ANGIOGENESIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17454,"idioma_id":4,"titulo":"Optimization of Proteins Recovery Process from Cheese Whey","resumen":"The process to obtain a protein-containing ingredient from&nbsp; the remaining whey of Argentinean ?Cuatriolo? cheese production was studied. In order to optimize the protein recovery, physical and chemical treatments were investigated. Two protocols with different sequences of application of heating step and acid addition were assayed in the presence and absence of fat and CaCl2. The results were evaluated by the yield, water retention and particle size. The results showed that the highest yield of the process (76.6%) and an increase in water retention (39.8 w\/w) were achieved when the acid was added after boiled and incubated for 30 min at 90 °C. In these working conditions, the presence of calcium shows a lower yield of recovery (72.8 %) and this behaviour correlates with a smaller particle size. Additionally, the presence of fat reduces the particle size and decreases the performance of the process (69.4%). Thus, the yield of protein recovery is related to the particle size of the aggregates, i.e., the recovery of proteins increases when increase the particle size. The simultaneous presence of fat and CaCl2 increases the amount of water retained in the aggregated protein (47.62 w\/w). In conclusion, the process of aggregation in whey protein should take into account both the design of suitable protocol and the presence of fat and additives.","palabras_clave":"Proteins|Recovery|Process|Cheese Whey"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17455,"idioma_id":4,"titulo":"Time-varying noise control in motorcycle helmets","resumen":"The time-varying approach is designed to have an attenuation level that increases with the speed between the helmet and the air (since the noise level increases  with speed) using a linear parameter-varying (LPV) controller. The main purpose here is to take advantage of this time-varying controller to tune the attenuation  level in accordance with the noise environment. In this way, the attenuation is higher at speeds where the external noise is louder and lower at reduced velocities.","palabras_clave":"Motorcycle helmets|Active noise control|Hinf optimal control|LPV"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17456,"idioma_id":5,"titulo":"Evolución a través del tiempo de la contaminación por dióxido de azufre en la ciudad de Rosario","resumen":"Este trabajo muestra la evolución y el comportamiento de las concentraciones de dióxido de azufre (SO2) en el aire urbano de la ciudad de Rosario en dos periodos de tiempo separados por aproximadamente dieciseis años y también los cambios introducidos en las fuentes de emisión.Los resultados obtenidos en cada uno de los puntos de monitoreo muestran que el SO2 es un contaminante que se evidencia en bajos niveles en el aire respirable de la ciudad de Rosario y que los valores encontrados para la única estación de monitoreo que permaneció en los dos períodos de medición analizados demuestran que, a pesar del aumento considerable de la circulación de vehículos en los últimos años, las concentraciones de este contaminante permanecen en valores constantes y muy bajos. Por ello se concluye que el aire urbano de la ciudad de Rosario se encuentra exento de un contaminante peligroso como lo es el SO2.","palabras_clave":"AIRE|AZUFRE|EVOLUCIÓN|EMISIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17457,"idioma_id":4,"titulo":"Analyzing the impact of conflictive dental characters on the phylogeny of octodontoid rodents","resumen":"Systematics of fossil octodontoids (Rodentia, Caviomorpha) is in great part based on insights into the knowledge of teeth, making the step of dental characterization certainly relevant for the evolutionary reconstruction of these rodents. Different homology hypotheses were proposed for the same tooth structures, a fact that indicates the importance of knowing on which criteria the dental characters supporting the classifications were based. In this line, I evaluate the step of characterization of certain conflictive molar characters previously used, and their impact on phylogeny of octodontoids. I explore which the criteria followed to propose the hypotheses of correspondences for these characters are in light of the anatomical evidence. Based on the outcome of phylogenetic trees obtained previously, I analyze if the evolutionary transformations are compatible with character states observed in the terminals. New cladistic analyses based on recoded molar characters indicate that, unlike results recently obtained, the unorthodox position of ?Sallamys, ?Protadelphomys, and ?Willidewu as basal ctenomyines is not recovered. The  position of ?Caviocricetus +, ?Acarechimys??Neophanomysas as Octodontinae is not  maintained. These results indicate that reanalyses of conflictive dental characters, scrutinizing data matrices, are particularly necessary to evaluate the current controversy on the phylogeny of octodontoids. Lower molar character definition and character states delimitation in octodontoids,  being relevant to phylogenetic reconstruction, should be founded on anatomical examination, following explicit criteria of homology. Alternative hypotheses of ?primary homology? proposed for the same molar traits in octodontoids indicate that each main group of caviomorphs requires its own anatomical study.","palabras_clave":"HOMOLOGY|SYSTEMATIC|PHYLOGENY|MOLAR MORPHOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17458,"idioma_id":4,"titulo":"A phylogenetically conserved group of NF-Y transcription factors interact to control nodulation in legumes","resumen":"The endosymbiotic association between legumes and soil bacteria called rhizobia leads to the formation of a new root-derived organ called the nodule in which differentiated bacteria convert atmospheric nitrogen into a form that can be assimilated by the host plant. Successful root infection by rhizobia and nodule organogenesis require the activation of symbiotic genes that are controlled by a set of transcription factors (TFs). We recently identified Medicago truncatula nuclear factor-YA1 (MtNF-YA1) and MtNF-YA2 as two M. truncatula TFs playing a central role during key steps of the Sinorhizobium meliloti-M. truncatula symbiotic interaction. NF-YA TFs interact with NF-YB and NF-YC subunits to regulate target genes containing the CCAAT box consensus sequence. In this study, using a yeast two-hybrid screen approach, we identified the NF-YB and NF-YC subunits able to interact with MtNF-YA1 and MtNF-YA2. In yeast (Saccharomyces cerevisiae) and in planta, we further demonstrated by both coimmunoprecipitation and bimolecular fluorescence complementation that these NF-YA, -B, and -C subunits interact and form a stable NF-Y heterotrimeric complex. Reverse genetic and chromatin immunoprecipitation-PCR approaches revealed the importance of these newly identified NF-YB and NF-YC subunits for rhizobial symbiosis and binding to the promoter of MtERN1 (for Ethylene Responsive factor required for Nodulation), a direct target gene of MtNF-YA1 and MtNF-YA2. Finally, we verified that a similar trimer is formed in planta by the common bean (Phaseolus vulgaris) NF-Y subunits, revealing the existence of evolutionary conserved NF-Y protein complexes to control nodulation in leguminous plants. This sheds light on the process whereby an ancient heterotrimeric TF mainly controlling cell division in animals has acquired specialized functions in plants.","palabras_clave":"nodulación|Factores de transcripción|complejos heterotriméricos|leguminosas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17459,"idioma_id":4,"titulo":"NEW HYPSODONT NOTOUNGULATE (HEGETOTHERIIDAE, PACHYRUKHINAE) FROM THE LATE MIOCENE OF THE EASTERN CORDILLERA, SALTA PROVINCE, NORTHWEST OF ARGENTINA","resumen":"Late Miocene fluvial strata of the Palo Pintado Formation are broadly exposed to the northwest of the town of Angastaco, Salta province, Northwest of Argentina. These strata accumulated in the extensional Angastaco Basin. Recent field work at the Palo Pintado Formation (late Miocene), Valle Calchaquí, Salta province, Argentina has provided fossil remains that greatly increased the knowledge of the faunal assemblage of this site. A number of notoungulatesand rodents were collected. A partial left jaw was collected at Quebrada Peñas Blancas along the west bank of the Río Calchaquí. Morphological and morphometric comparisons permit referral of this specimen to a new species of hegetotheriid notoungulate Paedotherium kakai sp. nov. It represents the first report of Paedotherium for the Eastern Cordillera and one of the few well-documented occurrences of this genus outside of middle-high latitudes Argentina. The widespread geographic range of Paedotherium, combined with its restricted temporal range, suggest it may be one of the most useful biostratigraphic indicator taxa for Neogene faunas. Paedotherium kakai would have been a mixed feeder that lived in gallery forests, feeding close to water bodies of a system river and lagoons, in food plains developed under humid and subtropical climate.","palabras_clave":"Hypsodont Notoungulate |Late Miocene"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17460,"idioma_id":4,"titulo":"Development of iron modified MCM-41 as promising nano-composites with specific magnetic behavior","resumen":"MCM-41 type mesoporous silica materials were synthesized and modified with different iron loadings by the wet impregnation method and exhaustively characterized by different instrumental techniques, including XRD, TEM, N2 adsorption, UV?Vis DRS, XPS, TPR and Mössbauer spectroscopy. The relation  between the iron loadings in the samples and their structural, textural and magnetic properties were studied. The curves of room temperature magnetization vs. field were measured using a maximum magnetic applied field of l0Ha = 1 T. Depending on the dispersion and size of the different iron species, the  nanocomposites showed different magnetic behaviors. Thus, a predominant superparamagnetic behavior was found for the samples with the lower iron loadings; this feature was assigned to oxide species finely dispersed such as the oligonuclear (FeO)n clusters and nanoparticles, both of very small size and located preferably inside the channels. Meanwhile, a lineal behavior was observed for the samples with the higher Fe loadings, attributed to the hematite nanoparticles of larger size, located on the external surface","palabras_clave":"Fe\/MCM-41|Iron speciation|Magnetic properties|Structural\/spectroscopic characterization|Superparamagnetism"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17461,"idioma_id":4,"titulo":"Growth inhibition and morphological alterations of Staphylococcus aureus caused by the essential oil of Aloysia triphylla","resumen":"Aloysia triphylla essential oil (EO) has antimicrobial activity on Staphylococcus aureus which is a pathogen responsible for severe infections and food contamination. The target of EO is mainly in the cytoplasmic membrane. In this work the mechanisms of action of the EO of A. triphylla on S. aureus were investigated. A. triphylla was collected from La Paz. The oil was analyzed by GC-MS. The antimicrobial effects were evaluated by MIC, MBC, killing time and TEM. MIC values were 23 µg\/mL for 6.3 x 104 CFU\/mL, 92 µg\/mL for 5.71 x 105 CFU\/mL and 180 µg\/mL for 9 x 106 CFU\/mL. The MBC was 5920 µg\/mL for all cellular concentrations and it was necessary more time to kill bigger cell populations. Multilamellar and mesosome-like structures on the membrane were seen by TEM. A. triphylla oil is an antibacterial compound against S. aureus which main mechanism of action seems to be the cytoplasmic membrane disruption.","palabras_clave":"ALOYSIA TRIPHYLLA|ESSENTIAL OIL|ANTIMICROBIAL ACTIVITY|STAPHYLOCOCCUS AUREUS|KILLING TIIME|ELECTRONIC MICROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17462,"idioma_id":5,"titulo":"Una propuesta creativa para la construcción de los conceptos de calor y capacidad calorífica mediante un modelo didáctico analógico","resumen":"Los principios de la termodinámica tienen una importancia fundamental para todas las ramas de la ciencia y de la tecnología, pero presentan dificultades en los estudiantes para su correcta conceptualización.  La utilización de modelos didácticos analógicos no sólo permite explorar la continuidad del progreso de la ciencia, sino que brinda la posibilidad de alcanzar una planificación didáctica que contextualiza la incorporación de nuevos conceptos a los procesos cognitivos de los estudiantes. De esta forma se convierten en una herramienta que permite abordar un fenómeno físico de una manera más simple, logrando despertar el interés de los alumnos y motivándolos en el aprendizaje de las ciencias.   En este artículo presentamos la continuación de una serie de trabajos basados en la enseñanza a través de modelos didácticos (Viau et al.; 2008a, 2009, 2010 y 2012) consistente en la utilización de un modelo que mediante un recurso ?áulico? permite introducir los conceptos termodinámicos de calor y capacidad calorífica y su distinción de los conceptos de temperatura y energía interna.","palabras_clave":"MODELOS DIDÁCTICOS|TERMODINÁMICA|CALOR|CAPACIDAD CALORÍFICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17463,"idioma_id":4,"titulo":"Lubricant quality control: A chemometric approach to assess wear engine in heavy machines","resumen":"Used  lubricants assessment could be suitable to reveal wear mechanisms undergoing in  a machine. In the proposed work an effective, reliable and cost-efficient  technique combining inductively coupled plasma optical emission spectrometry  (ICP-OES) and chemometrics was developed to perform wear analysis for  industrial application. Thus, multielemental determination of a large amount of  used lubricants from diesel heavy machines (truck, bulldozer, loaders and backhoe)  was carried out by ICP-OES. Multivariate analysis was done by the non  supervised method principal component analysis (PCA) and supervised method  sequential discriminant analysis (SDA). The recognition ability for the groups  was highly satisfactory. For PCA, the main three principal components explained  99.98% of total variance for samples lubricants. SDA allowed, in training and  prediction sets, a correct classification of 97.12% and 95.75% respectively for  the lubricant analyzed samples, obtaining three groups classified according to the  use. The outcomes demonstrate that lubricant wear effect could be assessed  quickly and accurately, having great potential to become a very useful tool in  the machine monitoring industry. ","palabras_clave":"Wear metals|Lubricant oils|Machine monitoring|Chemometrics techniques"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17464,"idioma_id":4,"titulo":"Chemical wear of Al2O3-MgO-C bricks by air and basic slag","resumen":"Abstract    Al2O3-MgO-C (AMC) refractories are used in steelmaking vessels such as ladles, where they are part of the working lining´s bottom and walls. Taking into account the conditions during the ladle operation, AMC refractories with high-melt corrosion resistance are required to provide good service performance. Moreover, due to the presence of graphite, AMC bricks should have low susceptibility to attack by oxidant gases. In this paper, the oxidation of commercial AMC refractories by air between 700 and 1400 °C and their corrosion by ladle basic slag at 1450 °C are examined. The experimental conditions for the chemical evaluation are similar to those to which AMC linings are exposed in some steps of the ladle operation. Differences in the chemical wear caused by both of the reagents among the studied bricks are associated to their differences in composition and microstructural and textural characteristics. In addition, the thermal evolution of each AMC refractory is considered.","palabras_clave":"AMC refractories|air oxidation|basic slag corrosion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17465,"idioma_id":4,"titulo":"Medicinal use of wild fauna by mestizo communities living near San Guillermo Biosphere Reserve (San Juan, Argentina)","resumen":"BackgroundWild and domestic animals and their by-products are important ingredients in the preparation of curative, protective and preventive medicines. Despite the medicinal use of animals worldwide, this topic has received less attention than the use of medicinal plants. This study assessed the medicinal use of animals by mestizo communities living near San Guillermo MaB Reserve by addressing the following questions: What animal species and body parts are used? What ailments or diseases are treated with remedies from these species? To what extent do mestizo people use animals as a source of medicine? Is the use related to people?s age?MethodsWe conducted semi-structured interviews with 171 inhabitants (15?93 years old) of four villages close to the Reserve: Tudcúm, Angualasto, Malimán and Colangüil. We calculated the informant consensus factor and fidelity level to test homogeneity of knowledge and to know the importance of different medicinal uses for a given species.ResultsThe medicinal use of animals was reported by 57% of the surveyed people. Seven species were mentioned: Rhea pennata, Lama guanicoe, Puma concolor, Pseudalopex sp., Lama vicugna, Lepus europaeus and Conepatus chinga. Several body parts were used: fat, leg, bezoar-stone, stomach, feather, meat, blood, feces, wool, and liver. The fat of R. pennata was the most frequently used animal part, followed by the bezoar stone and the leg of L. guanicoe. Animals were used to treat 22 ailments, with respiratory and nervous system disorders being the most frequently treated diseases with a high degree of consensus. Old people used animals as remedies more frequently than young residents, showing some differences among villages.ConclusionsA low number of animal species was mentioned as used for medicinal purposes, which could be explained by the perception of strong control related the legislation that bans hunting and the erosion of traditional knowledge produced by mestizaje. However, the presence of a traditional medicine is deeply rooted in the community culture. Management strategy for protected areas should focus not only on the conservation and sustainability of biological resources, but also on the ancestral knowledge of local communities, such as the medicinal use of animals.","palabras_clave":"MEDICINAL ANIMALS|MESTIZAJE|RURAL POPULATION|TRADITIONAL KNOWLEDGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17466,"idioma_id":4,"titulo":"Baccharis coridifolia Poisoning in Water Buffalo (Bubalus bubalis) in the North of the Province of Corrientes, Argentina","resumen":"Eight of 57 water buffalo (Bubalus bubalis) died after grazing 30 days on 38-hectare pasture contaminated with Baccharis coridifolia in the north of the Province of Corrientes (northeastern Argentina). Most were found dead, others showed depression, anorexia, diarrhea, incoordination of movements and collision against fences. The conditions that caused the poisoning were overgrazing, poor pasture and lack of aversion to the consumption of Baccharis coridifolia. Gross findings included necrotic rumenitis, necrotic-hemorrhagic abomasitis, necrotic-hemorrhagic enteritis and marked brain edema. The histopathological findings were necrosis of the epithelium of the mucosa of the forestomachs, necrosis and hemorrhage in mucosa of the small intestine, necrosis of lymphocytes in lymph follicles in spleen and thymus and vasogenic brain edema. The lesions, except for brain edema, are typically reported in cattle intoxicated by Baccharis coridifolia. Vasogenic brain edema is not described in any animal species naturally or experimentally intoxicated with this plant; this change may be due to direct toxic effect of Baccharis coridifolia that cause vascular injury or was a secondary injury.","palabras_clave":"POISONOUS PLANTS|WATER BUFFALO|NECROTIC RUMENITIS|BRAIN EDEMA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17467,"idioma_id":4,"titulo":"Parton to Pion Fragmentation Reloaded","resumen":"We present a new, comprehensive global analysis of parton-to-pion fragmentation functions at  next-to-leading order accuracy in QCD. The obtained results are based on the latest experimental  information on single-inclusive pion production in electron-positron annihilation, lepton-nucleon  deep-inelastic scattering, and proton-proton collisions. An excellent description of all data sets is  achieved, and the remaining uncertainties in parton-to-pion fragmentation functions are estimated  based on the Hessian method. Extensive comparisons to the results from our previous global analysis  are performed.","palabras_clave":"QCD|FRAGMENTATION|HADRONIZATION|PION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17468,"idioma_id":4,"titulo":"Assessment of polyaniline nanoparticles toxicity and teratogenicity in aquatic environment using Rhinella arenarum model","resumen":"With the rapid growth of nanotechnology and the applications of nanoparticles, environmental exposure to these particles is increasing. However, their impact in human and environmental health is not well studied. Anurans, with life stage comprising embryos, tadpoles and adults, have an extremely permeable skin which makes them excellent indicators of environmental health. This study evaluated the acute toxicity effects of polyaniline nanoparticles (PANI-Np) in different dispersant on embryos and larvae of Rhinella arenarum. The results showed that LC50 of PANI-Np dispersed in polyvinylpyrrolidone (PVP) were 1500mg\/L, while LC50 by PANI-Np dispersed in PVP+PNIPAM (polyN-isopropylacrilamide) showed a highest toxicity (1170mg\/L). The embryo teratogenicity increased with increasing exposure concentration in both kinds of PANI-Np although in PANI-Np1, there is an increased teratogenic effect associated with the polymer stabilizer PVP.","palabras_clave":"NANOPARTICLES|TERATOGENESIS|TOXICITY TEST|ECOTOXICOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17469,"idioma_id":4,"titulo":"Time dependent changes in the intestinal Ca(2+) absorption in rats with type I diabetes mellitus are associated with alterations in the intestinal redox state","resumen":"The aim was to determine the intestinal Ca2+ absorption in type I diabetic rats after different times of STZ induction, as well as the gene and protein expression of molecules involved in both the transcellular and paracelluar Ca2+ pathways. The redox state and the antioxidant enzymes of the enterocytes were also evaluated in duodenum from either diabetic or insulin-treated diabetic rats as compared to control rats. Male Wistar rats (150?200 g) were divided into two groups: 1) controls and 2) STZ-induced diabetic rats (60 mg\/kg b.w.). A group of diabetic rats received insulin for five days. The insulin was adjusted daily to maintain a normal blood glucose level. Five 5 d after STZ injection, there was a reduction in the intestinal Ca2+ absorption, which was maintained for 30 d and disappeared at 60 d. Similar changes occurred in the GSH and &#729;O2&#8722; levels. The protein expression of molecules involved in the transcellular pathway increased at 5 and 30 d returning to control values at 60 d. Their mRNA levels declined considerably at 60 d. The gene and protein expression of claudin 2 was upregulated at 30 d. Catalase activity increased at 5 and 30 d normalizing at 60 d. To conclude, type I D.m. inhibits the intestinal Ca2+ absorption, which is transient leading to a time dependent adaptation and returning the absorptive process to normal values. The inhibition is accompanied by oxidative stress. When insulin is administered, the duodenal redox state returns to control values and the intestinal Ca2+ absorption normalizes.","palabras_clave":"STREPTOZOTOCIN|TRANSCELLULAR CA2+ PATHWAY|ANTIOXIDANT ENZYMES|GLUTATHIONE|VITAMIN D METAOLITES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17470,"idioma_id":4,"titulo":"GABAERGIC CONTROL OF ANXIETY-LIKE BEHAVIOR, BUT NOT FOOD INTAKE, INDUCED BY GHRELIN IN THE INTERMEDIATE MEDIAL MESOPALLIUM OF THE NEONATAL CHICK","resumen":"Ghrelin (Grh) is an endogenous ligand of the growth hormone secretagogue receptor. In neonatal chicks, central Ghr induces anxiogenic-like behavior but strongly inhibits food intake. The intermediate medial mesopallium (IMM) of the chick forebrain has been identified to be a site of the memory formation, and the modulation of the GABAA receptors that are present here modifies the expression of behavior. Thus, the GABAergic system may constitute a central pathway for Ghr action in regulating the processes of food intake and stress-related behaviors. Therefore, we investigated if the effect of systemic administration of bicuculline (GABAA receptor antagonist) and diazepam (benzodiazepine receptor agonist) on the anxiety in an Open Field test and inhibition in food intake induced by Grh (30pmol) when injected into IMM, were mediated by GABAergic transmission. In Open Field test, bicuculline was able to block the anxiogenic-like behavior induced by Ghr, whereas diazepam did not produce it. However, the co-administration of bicuculline or diazepam plus Ghr did not show any change in food intake at 30, 60 and 120min after injection compared to Ghr alone. Our results indicate for the first time that Ghr, injected into the forebrain IMM area, induces an anxiogenic-like behavior, which was blocked by bicuculline but not diazepam, thus suggesting that Ghr plays an important role in the response pattern to acute stressor, involving the possible participation of the GABAergic system. Nevertheless, as neither drug affected the hypophagia induced by intra-IMM Ghr, this suggests that it may be mediated by different mechanisms.","palabras_clave":"Ghrelin |Gaba |Chicken"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17471,"idioma_id":4,"titulo":"A model for the development of  Aedes (Stegomyia) aegypti as a function of the available food.","resumen":"We discuss the preimaginal development of the mosquito Aedes aegypti from the point of view of thestatistics of developmental times and the final body-size of the pupae and adults. We begin thediscussion studying existing models in relation to published data for the mosquito. The data suggest adevelopmental process that is described by exponentially distributed random times. The existing datashow as well that the idea of cohorts emerging synchronously is verified only in optimal situationscreated at the laboratory but it is not verified in field experiments. We propose a model in whichimmature individuals progress in successive stages, all of them with exponentially distributed times,according to two different rates (one food-dependent and the other food-independent). This phenom-enological model, coupled with a general model for growing, can explain the existing observations andnew results produced in this work. The emerging picture is that the development of the larvae proceedsthrough a sequence of steps. Some of the steps depend on the available food. While food is in abundance,all steps can be thought as having equal duration, but when food is scarce, those steps that depend onfood take considerably longer times. For insufficient levels of food, increase in larval mortality sets in.As a consequence of the smaller rates, the average pupation time increases and the cohort disperses intime. Dispersion, as measured by standard deviation, becomes a quadratic function of the average timeindicating that cohort dispersion responds to the same causes than delays in pupation and adultemergence. During the whole developmental process the larva grows monotonically, initially at anexponential rate but later at decreasing rates, approaching a final body-size. Growth is stopped bymaturation when it is already slow. As a consequence of this process, there is a slight bias favoring smallindividuals: Small individuals are born before larger individuals, although the tendency is very weak.","palabras_clave":"larvae maturation|time|statistics|body size|Aedes aegypti"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17472,"idioma_id":4,"titulo":"Antioxidant Activity of Butterhead Lettuce: Evaluation of Significant Factors Affecting Antioxidant Extraction and Quantification","resumen":"This work presents a standardized methodology for both the extraction of antioxidants from butterhead lettuce and the evaluation of the antioxidant capacity through DPPH methodology. The standardized extraction of antioxidants requires processing the fresh lettuce leaves (1 g) for 1 min, mixing with 10 mL of acidified ethanol (0.5 or 1 % citric acid) maintaining this mixture with continuous shaking during 1 h at 2 °C. After that, a centrifugation at 8000 rpm for 15 min is necessary to obtain a fist supernatant (antioxidant source). A second extraction step with acetone:water (70:30 v\/v) improves the extraction yield. Extracts can be stored for 14 days at -20 ºC without changes in its antioxidant capacity. For quantification, a mixture 1:4 of lettuce extract and DPPH (100 &#61549;M) must be incubated for 60 min at 2 ºC in dark before reading at 517 nm. Expression of results in terms of mg ascorbic acid equivalents\/100 g fresh weight is recommended in order to compare results from different studies. A kinetic study of the reaction between lettuce antioxidants and DPPH was adjusted to a biphasic first-order kinetic model and showed evidence of the presence of antioxidants of slow and rapid antioxidants in lettuce extracts.","palabras_clave":"Lettuce|Antioxidants|Radical scavenging capacity|DPPH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17473,"idioma_id":4,"titulo":"'Analysis of major and trace elements in crude drug and infusions of Pluchea sagittalis (Asteraceae)?.","resumen":"Se analiza....","palabras_clave":"ICP|Medicinal herbs|Pluchea sagittalis|trace elements"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17474,"idioma_id":5,"titulo":"Reflexiones sobre los intentos de reforma del estatuto en la Universidad Nacional de Mar del Plata, una aproximación a los factores que intervinieron en el proceso","resumen":"Las universidades nacionales de gestión pública son organizaciones complejas  porque conviven en ellas una multiplicidad de finalidades, necesidades estructurales de recursos diversos -por lo general escasos- procesos que involucran distintas especialidades y disciplinas, las administraciones generalmente se encuentran condicionadas por  rígidos sistemas burocráticos con personal altamente capacitado cuyo trabajo es difícil de formalizar y coordinar, y  cuentan con un complejo sistema de gobierno.  La función de gobierno en la comunidad universitaria presenta ciertas características, es ejercida en forma colegiada -mediante la acción del co-gobierno que llevan a cabo representantes de los  claustros docentes, estudiantes y graduados-, es multidisciplinar producto de la representación por facultades y es dinámica ya que los órganos colegiados y unipersonales se renuevan periódicamente.   Desde el año 2000 al año 2013 la Universidad Nacional de Mar del Plata (UNMDP) ha intentado reformar su estatuto en tres oportunidades, en el último de ellos pudo finalmente cumplir su objetivo. Explorar los factores intervinientes en este proceso es el propósito de este trabajo.","palabras_clave":"universidad|estatuto|crisis|poder"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17475,"idioma_id":4,"titulo":"Synthesis and characterization of latex nanoparticles using  a visible-light photoinitiating system in reverse micelles","resumen":"This work shows the feasibility of using the photoinitiating system composed by the xanthene dye Eosin-Y and triethanolamine on the polymerization of acrylamide in benzyl-hexadecyl-dimethylammonium chloride (BHDC) reverse micelles. Molecular weights of polyacrylamide (MWPAA) in the order of 105 and conversions up to 90 %are obtained. The size of the latex particles is in the range of the nanometers (d<50 nm). The effect of water content and concentrations of surfactant, amine, dye, and monomer on the particle size and MWPAA are examined. Only the amine andmonomer concentrations affect the MWPAA. These results are interpreted on the basis of an exchange mechanism between micelles. Practically no effect on hydrodynamic diameters is observed when the value of MWPAA is doubled. This isascribed to a supercoiled structure of PAA inside of micelles.Our results also suggest that the polymer properties can be modulated by appropriate combination of the dye\/surfactant electrical charges.","palabras_clave":"DYES|DYNAMIC LIGHT SCATTERING|NANOPARTICLES|PHOTOPOLYMERIZATION|REVERSE MICELLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17476,"idioma_id":4,"titulo":"Triplet state quenching of phenosafranine dye by indolic compounds studied by transient absorption spectroscopy","resumen":"The interaction of the triplet state of the synthetic dye phenosafranine (3,7-diamino-5-phenylphenaziniumchloride) with indolic compounds of biological relevance was investigated in water by means oflaser flash photolysis. The rate constants for the triplet quenching were determined. The quenchingprocess may be explained by an electron transfer from the indole to the dye in its triplet state. The rateconstants present a typical dependence of an electron transfer process with the one-electron oxidationpotential of the indole. Indole-3-acetic acid and its homologous indole propionic and indole butyric acidsare the most effective quenchers with rate constants reaching the diffusion limit. Rate constants forindole itself, tryptophan and indole-3 carboxylic acid are one order of magnitude lower. The electrontransfer nature of the quenching reaction is further confirmed by the detection of the semi-reduced formof the dye by its transient absorption. The absorption coefficients of the transient species were estimated,and the quantum yield of the charge separation process was determined. The efficiency of formation ofradical species is between 60 and 90% of the triplets intercepted.","palabras_clave":"Phenosafranine|Indolic compounds|Flash photolysis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17477,"idioma_id":5,"titulo":"MORFOSEDIMENTOLOGÍA DEL FONDO MARINO EN EL SECTOR DE ENTRADA AL ESTUARIO DE BAHÍA BLANCA, ARGENTINA","resumen":"In the large Bahia Blanca estuarine system (province of Buenos Aires) there are sectors without a comprehensive assessment of submarine morpho-sedimentological features. Within this context, in this paper the seabed along the north coast of the entrance to the Principal channel of the estuary is studied. Acoustic surveys (echo sounder and side scan sonar) and sediments sampling were performed. The presence of depositional and erosional geoforms was determined. Among those of accretional nature have been established different types of dunes and sand ribbons. The erosive forms are scarps, relatively continuous and irregular, and rocky isolated outcrops. Also, seabed cohesive sediments, both massive and stratified, were differentiated. As anthropogenic forms furrows dredging and the presence of pipes for oil and metal debris were distinguished. The analysis of geoforms and sediments determined that in the east sector of the coastal strip studied prevails sediment transport as bedload towards the Continental Shelf, while in shallow waters of the western sector, there is a marked litoral drift towards the inside of estuary. The conjunction of morphological and sedimentological data allowed to extend the characterization of two ancient coastal levels, indicative of stabilization periods of sea level during the last transgressive process. ","palabras_clave":"FORMAS DE FONDO|SEDIMENTOS|PALEOCOSTAS|HOLOCENO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17478,"idioma_id":5,"titulo":"Tecnologia de tratamiento de residuos del olivar para obtener compost y viabilidad de su aplicación","resumen":"Los residuos de poda del olivar y de la extracción del aceite de oliva se han incrementado en las provincias de Catamarca y La Rioja durante los últimos  años surgiendo la necesidad de gestionarlos empleando tecnologías amigables con el ambiente.  La biodegradación de sustancias contenidas en el alpeorujo y hojas del olivo conjuntamente con estiércoles de ganado caprino y caballar propició la obtención de  enmiendas orgánicas de calidad aceptable para su utilización como mejoradores de las propiedades de los suelos de uso agrícola.  Los resultados  expuestos en el  presente artículo completo fueron logrados a través de ensayos experimentales llevados a cabo en una empresa oleícola del medio y predio de la UNCa y  financiados por el Ministerio de Ciencia, Tecnología e Innovación Productiva de Argentina.","palabras_clave":"gestión de residuos|compost|alperujo|aceite de oliva"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17479,"idioma_id":4,"titulo":"Thiodisaccharide Sulfoxides: Absolute Configuration of the SO Sulfur Atom and Influence on the Biological Activity towards the &#946;-Galactosidase from E. coli","resumen":"Benzyl 3-deoxy-4-S-(B-D-galactopyranosyl)-4-thio-B-D-threopentopyranoside is a potent inhibitor of the B-galactosidase from Escherichia coli synthesized in our laboratory. The  2´,3´,4´,6´-tetra-O-acetyl derivative of this thiodisaccharide  was oxidized with m-chloroperoxybenzoic acid to give a 2:1  diastereomeric mixture of sulfoxides S and R. The absolute  configurations of their sulfur stereocenters were determined  by using NMR techniques and by taking into account the  anisotropic effects of the S=O group in the major conformers.  O-Deacetylation of S and R afforded the free thiodisaccharide  S-oxides, which were evaluated as inhibitors  of the above-mentioned enzyme. The kinetic studies  showed that S and R are competitive inhibitors of the enzyme with Ki values of 0.19 and 0.45 mM, respectively. Further  enzymatic reactions demonstrated that the S isomer is also a substrate  of the B-galactosidase, as it was diastereoselectively  hydrolyzed, while the R isomer remaining unchanged under the same  conditions.","palabras_clave":"Carbohydrates|Enzymes| Inhibitors|Biomimetics|Sulfoxides|Configuration determination"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17480,"idioma_id":4,"titulo":"Modeling Spatial Correlation Structure in Sugarcane (Saccharum spp.) Multi- Environment Trials","resumen":"Comparative multienvironment trials (METs) of sugarcane genotypes are frequently conducted using a randomized complete-block design (RCBD) within environments. However, blocking does not always ensure spatial variation control because of differential competition for resources among neighboring genotypes. Heterogeneity within trials may also cause between-trial heterocedasticity. This work aims to evaluate different Linear Mixed Models (LMMs) that enable the analysis of spatial correlation and residual heterogeneity among trials for both tons of cane per hectare (TCH) and sucrose content (SC%) in three series of mutienvironmetal trials conducted to evaluate advanced sugarcane clones. A total of 16 sugarcane trials conducted at different sites and in different crop cycles (age) were analyzed. Individual (age×site combination) and multienvironment analyses were performed. For SC%, the classic RCBD analysis within trial was adequate. For TCH, the anisotropic autoregressive model of order 1 (AR1×AR1) was the best to compare genotype means in most trials, allowing gain in information equivalent, on average, to the addition of 1.6 replicates to the original design. In the case of multienvironment analysis, the AR1×AR1 within-trial with among-trial heteroscedasticity was the best model to compare variety means, both for TCH and SC%. The results showed how a more appropriate mixed model would help avoid commission of judgment errors in sugarcane variety recommendations.","palabras_clave":"ANISOTROPIC-AUTOREGRESSIVE SPATIAL MODELS|EFFICIENCY|EXPERIMENTAL DESIGN|LINEAR MIXED MODEL|YIELD TRIALS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17481,"idioma_id":4,"titulo":"The Ln^m--propositional calculus","resumen":"T. Almada and J. Vaz de Carvalho (2001) stated the problem to investigate if   these algebras are algebras of some logic system. In this article an affirmative answer is given and the Lnm -propositional calculus, denoted by lnm , is introduced in terms of the binary connectives &#8594; (implication), &#1417; (standard implication), &#8743; (conjunction), &#8744; (disjunction) and the unary ones f (negation) and Di (generalized Moisil operators). It is proved that lnm belongs to the class of standard systems of implicative extensional propositional calculi. Besides, it is shown that the definitions of Lnm-algebra and lnm-algebra are equivalent. Finally, the completeness theorem for lnm is obtained.","palabras_clave":"LUKASIEWICZ ALGEBRA OF ORDER N|M-GENERALIZED LUKASIEWICZ ALGEBRA OF ORDER N|IMPLICATIVE EXTENSIONAL PROPOSITIONAL CALCULUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17482,"idioma_id":4,"titulo":"Differential effects of cold stress on the antioxidant response of mycorrhizal and non mycorrhizal Jatropha curcas (L) plants.","resumen":"Our main objective was to analyze the protection provided by Mycorrhiza (Rhizophagus intraradices) to Jatropha curcas plants under cold stress, through the analysis of physiological and oxidative stress parameters. Mycorrhizal (AM) and non-mycorrhizal (nonAM) plants were exposed to cold stress 4±1 ºC temperature for 72 h. The control plant grow at 25 ±1 ºC. Under cold stress, the stomata conductance decreased both AM and nonAM plants and photosynthetic efficiency only in non AM plants. The CAT activity increased in AM plants independently of stress conditions. GR activity shows a typical rise to cold stress in nonAM plants and decreasedin AM ones. With cold stress, the APX activity was reduced in all treatments and SOD activity was not affected in all treatment The MDA content increased in nonAM plants while in AM plants it was unaffected by low temperature. This study reported on the regulation of antioxidant compounds, their relationship to the AM symbiosis and cold stress in Jatropha curcas L.","palabras_clave":"COLD |STRESS|ANTIOXIDANTS|MYCORRHIZA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17483,"idioma_id":4,"titulo":"Localization of m  generalized Lukasiewicz algebras of order n","resumen":"In 2001, m-generalized Lukasiewicz algebras of order n (or Lnm-  algebras) were introduced by J. Vaz de Carvalho and T. Almada as a   generalization of Lukasiewicz algebras of order n and a particular case  of Ockham algebras. In this article the localization on Lnm?algebras is developed. More precisely, the Lnm-algebra of fractions relative to a &#8743;-closed system is obtained. Besides, the concept of F?multiplier where F is a topology on an Lnm?algebra L is defined and it is proved that the Lnm-algebra of fractions L[C] associated with an &#8743;?closed system C of L is isomorphic to the localization Lnm?algebra LFC with respect to the topology FC associated to C. Finally, the notion of Lnm?algebra of quotients is considered and the existence of a maximal quotients Lnm ?algebra is shown.","palabras_clave":"M GENERALIZED LUKASIEWICZ ALGEBRAS OF ORDER N|MULTIPLIERS|LOCALIZATION ALGEBRAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17484,"idioma_id":4,"titulo":"Hazards for women and children in rural settings","resumen":"Objectives a) To identify possible risk factors associated with rural accidentsin women, b) to describe women?s knowledge about zoonosis, c) to describewomen?s risk perception about farming, d) to describe mother´s risk perceptionabout children?s activities in rural settings, e) to estimate the initial age of exposure to the rural setting and its dangers, and f) to identify possible risk factors associated with rural accidents in children.Materials and Methods Cross-sectional design. Women with children that live in the countryside were surveyed (n=24). Structured questionnaire. Statistical analyses: &#967;2, Student?s t-test, Pearson?s correlation coefficient and logistic regression.Results Many women had suffered an accident in the countryside (65.6 %).Farm worker usually did not use personal protective equipment (PPE). Hearingprotection, gloves, and safety goggles were rarely used. Working women showeda high risk perception for urban driving, the handling of agrochemicals, and driving on main roads (85.7 %, 70 % and 66.7 %). There was no significant association between risk perception and PPE use. Most mothers (87.5 %) thought that was good for children to learn how to perform farm chores starting at a young age. Children started to drive a tractors at 9 years of age; 12.23 years on average. More than 7 % of the children (7.14 %) have suffered an accident on the farm. The most frequent accidents were being trapped in machinery (60 %). No association was found between the independent variables and the dependent variable; farm-related accidents in children (p>0.2).Conclusions Risk communication is necessary to inform people involved and toreduce exposure.","palabras_clave":"ACCIDENT|CHILD|RISK PERCEPTION|WOMEN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17485,"idioma_id":5,"titulo":"Hidratación y propiedades de cemento ternarios con filler calcáreo y escoria","resumen":"Los cementos ternarios con adiciones minerales que presentan un comportamientocomplementario durante la hidratación permiten maximizar el contenido de adición. El fillercalcáreo (F) produce un incremento de la hidratación temprana debido al efecto físico(relleno y nucleación heterogénea). El efecto de dilución contrarresta estos beneficios ylimita el contenido de filler. Por otro lado, la escoria (E) reacciona lentamente generando elrefinamiento de granos y poros, y contribuyen a mejorar las propiedades mecánicas ydurables. En este trabajo se estudia la hidratación de cementos con F (0 a 20 %) y E (0 a35%), empleando el modelo de Powers ampliado por Chen &amp; Browers para escoria. El gradode hidratación fue estimado a través del contenido de agua no evaporable. A partir de losresultados de la hidratación, se analizan la resistencia mecánica del hormigón (w\/c = 0.50), ydel proceso de segmentación de poros en relación con la tasa de absorción capilar. Losresultados muestran una limitación del contenido de F para obtener una respuesta adecuadade la resistencia mecánica y durable a largas edades, y del contenido de E para obtenervalores apropiados a temprana edad.","palabras_clave":"FILLER CALCAREO|ESCORIA|RESISTENCIA|ABSORCION CAPILAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17486,"idioma_id":5,"titulo":"La investigación científica como misión académica de los hospitales públicos universitarios","resumen":"En un hospital universitario, la asistencia, la educación y la   investigación están ligadas entre sí. Es propósito de este trabajo   destacar la significación de la investigación científica como misión   académica de los hospitales públicos universitarios. La integración de   la investigación con la práctica clínica garantiza mayor calidad en los   servicios de salud, mejor implantación de los avances médicos en la   prevención y tratamiento de las enfermedades y un cuidado más ético y   eficiente para los pacientes. Lograr tal integración implica una   asistencia médica de excelencia, unos profesionales mejor formados y más   reconocidos en su quehacer investigativo, un financiamiento suficiente y   claro, la integridad del sistema institucional que da soporte a la   actividad investigativa y la incorporación sostenida de investigadores   jóvenes. Son necesarios cambios en la enseñanza de la medicina, en la   organización de la investigación y en la organización hospitalaria. A   esta última le corresponde afrontar el reto de la investigación   traslacional. El hospital universitario reúne las características para   nuclear la investigación traslacional y brindar una alternativa de   acción efectiva a la compleja relación existente entre la investigación   en salud y la toma de decisiones a nivel político, para lograr   finalmente el acercamiento entre la asistencia y la investigación. Los   responsables hospitalarios han de tomar conciencia de que la   investigación biomédica es también un producto hospitalario. Los   hospitales universitarios y otros, de menor o mayor complejidad, deben   realizar actividades asistenciales, docentes y de investigación, para   brindar una asistencia de calidad haciendo uso de la mejor evidencia   científica disponible.","palabras_clave":"SCIENTIFIC  RESEARCH|ACADEMIC ROLE|TRANSLATIONAL RESEARCH|UNIVERSITY HOSPITALS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17487,"idioma_id":4,"titulo":"Bayesian approach to the inverse problem in a light scattering application","resumen":"In this article, static light scattering (SLS) measurements are processed to estimate the particle size distribution of particle systems incorporating prior information obtained from an alternative experimental technique: scanning electron microscopy (SEM). For this purpose we propose two Bayesian schemes(one parametric and another non-parametric) to solve the stated light scattering problem and take advantage of the obtained results to summarize some features of the Bayesian approach within the context of inverse problems. The features presented in this article include the improvement of the results when someuseful prior information from an alternative experiment is considered instead of a non-informative prior as it occurs in a deterministic maximum likelihood estimation. This improvement will be shown in terms of accuracy and precision in the corresponding results and also in terms of minimizing the effect of multipleminima by including significant information in the optimization. Both Bayesian schemes are implemented using Markov Chain Monte Carlo methods. They have been developed on the basis of the Metropolis? Hastings (MH) algorithm using Matlab® and are tested with the analysis of simulated and experimental examples of concentrated and semi-concentrated particles. In the simulated examples, SLS measurements were generated using a rigorous model, while the inversion stage was solved using an approximate model in both schemes and also using the rigorous model in the parametric scheme. Priors from SEM micrographswere also simulated and experimented, where the simulated ones were obtained using a Monte Carlo routine. In addition to the presentation of these features of the Bayesian approach, some other topics will be discussed, such as regularization and some implementation issues of the proposed schemes,among which we remark the selection of the parameters used in the MH algorithm.","palabras_clave":"Inverse Problem |Bayes Estimation|Static Light Scattering|paticle size distribution"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17488,"idioma_id":4,"titulo":"Effect of the number of orifices and operative variables on the heat and mass transfer in a hydrofluidization system with static spheres","resumen":"Hydrofluidization is a method of chilling and\/or freezing that uses submerged  jets of a refrigerating liquid. The objective of this work was to study the  effect of refrigerant temperature (-5°C, -10°C), fluid velocity at the jet exit (1.18 m s-1,  2.36 m s-1), distance between adjacent jets (1 cm, 2 cm), and  distance between spheres and jet exit (1 cm, 5 cm) on the heat and mass  transfer in a hydrofluidization system (e.g.  heat transfer coefficient, turbulence intensity, solute concentration in the  food) with several static spheres using a previously developed and validated  mathematical model via CFD simulations.  The variables that most affected the transport phenomena in the fluid domain  were the distance between spheres and jet exit, the distance between adjacent  jets, the fluid velocity at the jet exit, and the distance between spheres. The  refrigerant temperature only had significant effect on the transport phenomena  inside the food samples.","palabras_clave":"HYDROFLUIDIZATION|CFD|FOOD|HEAT TRANSFER|MASS TRANSFER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17489,"idioma_id":4,"titulo":"Fouling community dominated by Metridium senile (Cnidaria, Anthozoa, Actiniaria) in Bahía San Julián (Southern Patagonia, Argentina)","resumen":"The objective of this study is to provide information about a harbor fouling community dominated by Metridium senile in Southern Patagonia. Several steel tubes of the wharf of Puerto San Julián were extracted to perform repair tasks, allowing study the attached benthic community. Sampling was conducted at three levels: lower intertidal; 3-4 m depth subtidal and 6-7 m depth subtidal. In the lower intertidal, M. senile provided a relative abundance of 43%, being accompanied by Perumytilus purpuratus, Mytilus edulis platensis and Aulacomya atra atra, among the most abundant species. In subtidal levels the anemone presented abundances of 64 and 65%, being accompanied by Monocorophium insidiosum in the 3-4 m depth level and by Sabellidae and Syllidae at the deepest level. In the lower intertidal, epibiosis was more frequently on P. purpuratus, A. atra atra and M. edulis platensis. In subtidal levels the substrate-organisms diversity increased significantly and the anemone was fixed to A. atra atra, M. edulis platensis, Paramolgula gregaria, Crepipatella dilatata, Austromegabalanus psittacus, Hiatella arctica, Polyzoa opuntia, Pyura sp. and Sabellidae tubes. The great plasticity of M. senile to settle on different organisms, along with other strategies, makes it a colonizer able to displace other species that could compete by substrate. Given the cosmopolitan nature of M. senile; that this species has not been previously reported in the region; and taking into account our results, we discuss the possibility of consider this sea anemone as invasive alien species in Argentina.","palabras_clave":"FOULING|METRIDIUM SENILE|EPIBIOSIS|SOUTHERN PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17490,"idioma_id":4,"titulo":"Early response of wheat seminal roots growing under copper excess","resumen":"Growth reduction caused by copper excess during   plant photoautotrophic metabolism has been widely investigated, but   information regarding early responses of root apical meristem (RAM) to   toxic concentrations of this metal at the initial heterotrophic stage is   certainly scarce. We analysed some determinants of seminal root growth   in developing wheat seedlings germinated in the presence of 1, 5 and   10 &#956;M CuCl2, focussing on oxidative damage to cell membrane   and to proteins, and investigated the expression patterns of some genes   relevant to cell cycle progression and cell expansion. The proliferation   zone of the RAM was shorter under 5 and 10 &#956;M CuCl2. Cyclin D and CDKA levels remained unchanged in the root apexes of wheat seedlings grown under these Cu2+ concentrations, but more carbonylated levels of both proteins and less ubiquitinated-cyclin D was detected under 10 &#956;M CuCl2. Increased levels of ROS were revealed by fluorescent probes at this Cu2+ dose, and severe cell membrane damage took place at 5 and 10 &#956;M CuCl2.   Several genes related to retinoblastome phosphorylation and therefore   involved in the transition from G1 to S cell cycle stage were found to   be downregulated at 10 &#956;M CuCl2, while most expansin genes here analysed were upregulated, even at a non-toxic concentration of 1 &#956;M.    These   results together with previous findings suggest that a ?common? signal   which involves oxidative posttranslational modifications of specific   cell cycle proteins may be necessary to induce root growth arrest under   Cd2+ and Cu2+ stress.","palabras_clave":"COPPER|GROWTH|TRITICUM|AESTIVUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17491,"idioma_id":4,"titulo":"Allosteric regulation of the partitioning of glucose-1-phosphate between glycogen and trehalose biosynthesis in Mycobacterium tuberculosis","resumen":"Mycobacterium tuberculosis is a pathogenic prokaryote adapted to survive in hostile environments. In this organism and other Gram-positive actinobacteria, the metabolic pathways of glycogen and trehalose are interconnected.  RESULTS:  In this work we show the production, purification and characterization of recombinant enzymes involved in the partitioning of glucose-1-phosphate between glycogen and trehalose in M. tuberculosis H37Rv, namely: ADP-glucose pyrophosphorylase, glycogen synthase, UDP-glucose pyrophosphorylase and trehalose-6-phosphate synthase. The substrate specificity, kinetic parameters and allosteric regulation of each enzyme were determined. ADP-glucose pyrophosphorylase was highly specific for ADP-glucose while trehalose-6-phosphate synthase used not only ADP-glucose but also UDP-glucose, albeit to a lesser extent. ADP-glucose pyrophosphorylase was allosterically activated primarily by phosphoenolpyruvate and glucose-6-phosphate, while the activity of trehalose-6-phosphate synthase was increased up to 2-fold by fructose-6-phosphate. None of the other two enzymes tested exhibited allosteric regulation.  CONCLUSIONS:  Results give information about how the glucose-1-phosphate\/ADP-glucose node is controlled after kinetic and regulatory properties of key enzymes for mycobacteria metabolism.  GENERAL SIGNIFICANCE:  This work increases our understanding of oligo and polysaccharides metabolism in M. tuberculosis and reinforces the importance of the interconnection between glycogen and trehalose biosynthesis in this human pathogen.","palabras_clave":"ADP-glucose pyrophosphorylase|UDP-glucose pyrophosphorylase|Trehalose-6 P synthase|glycogen synthase"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17492,"idioma_id":4,"titulo":"The UDP-glucose pyrophosphorylase from Giardia lamblia is redox regulated and exhibits promiscuity to use galactose-1-phosphate","resumen":"Background: Giardia lamblia is a pathogen of humans and other vertebrates. The synthesis of glycogen and of structural oligo and polysaccharides critically determine the parasite's capacity for survival and pathogenicity. These characteristics establish that UDP-glucose is a relevant metabolite, as it is a main substrate to initiate varied carbohydrate metabolic routes.Results: Herein, we report the molecular cloning of the gene encoding UDP-glucose pyrophosphorylase from genomic DNA of G. lamblia, followed by its heterologous expression in Escherichia coli. Thepurified recombinant enzyme was characterized to have a monomeric structure. Glucose-1-phosphate and UTP were preferred substrates, but the enzyme also used galactose-1-phosphate and TTP. The catalytic efficiency to synthesizeUDP-galactose was significant. Oxidation by physiological compounds (hydrogen peroxide and nitric oxide) inactivated the enzyme and the process was reverted after reduction by cysteine and thioredoxin. UDP-Nacetyl-glucosamine pyrophosphorylase, the other UTP-related enzyme in the parasite, neither used galactose-1-phosphate nor was affected by redox modification.Conclusions: Our results suggest that in G. lamblia the UDP-glucose pyrophosphorylase is regulated by oxidoreduction mechanism. The enzyme exhibits the ability to synthesize UDP-glucose and UDP-galactose and it plays a key role providing substrates to glycosyl transferases that produce oligo and polysaccharides.General significance: The characterization of the G. lamblia UDP-glucose pyrophosphorylase reinforces the view that in protozoa this enzyme is regulated by a redox mechanism. As well, we propose a new pathway for UDPgalactose production mediated by the promiscuous UDP-glucose pyrophosphorylase of this organism.","palabras_clave":"UDP-glucose pyrophosphorylase|Redox-regulated|Glucose-1-phosphate|Galactose-1-phosphate"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17493,"idioma_id":4,"titulo":"Damage assessed by Wavelet scale bands and b-value in dynamical tests of a reinforced concrete slab monitored with acoustic emission","resumen":"The complex Morlet Continuous Wavelet Transform (CWT) was applied to Acoustic Emission(AE) signals from dynamic tests conducted on a reinforced concrete slab with a shaking table.The steel reinforcement bars did not yield during the tests, but a severe loss of bond betweenreinforcement bars and surrounding concrete was detected. Comparison of the evolution of thescale position of maximum values of CWT coefficients and the histories of responseacceleration obtained in different seismic simulations allowed us to identify the (45-64 kHz)frequency band corresponding to the fracture of concrete. The Cumulative Acoustic EmissionEnergy (CAE) obtained by reconstructing the AE signals in this scale (frequency) band wascompared with the Cumulative Dissipated Energy (CDE) of the tested structure. The CDE isaccepted as a good parameter for characterizing the mechanical damage in structures. Areasonably good agreement was found between the normalized histories of CAE and CDE. Thismade it possible to categorize the cracking of concrete as the main source of damage in thereinforced concrete slab. Conversely, the differences between the CAE and CDE curvesobserved for high levels of peak acceleration applied to the shaking table can be attributed tothe deformation of the steel that formed the columns. The AE coming from the plasticdeformation of the steel is not detected by CAE due to the threshold amplitude (45 dB) used inthe AE monitoring, but the strain energy dissipated by the steel through plastic deformations isincluded in the CDE. Further, a study of the evolution of the b-value in the successive seismicsimulations revealed that the b-value can capture the inception of severe cracking in theconcrete, which the tests described in this study attributed mainly to the loss of bond betweenreinforcing steel and surrounding concrete.","palabras_clave":"ACOUSTIC EMISSION SIGNALS    |DAMAGE|CONTINUOUS WAVELT TRANSFORM|b-VALUE|REINFORCED CONCRETE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17494,"idioma_id":4,"titulo":"Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity","resumen":"Sphingolipids are relevant lipid components of eukaryotic cells. Besides regulating various cellular  processes, sphingolipids provide the structural framework for plasma membrane organization.  Particularly, sphingomyelin (SM) is associated with detergent-resistant microdomains. We have  previously shown that the adherens junction (AJ) complex, the relevant cell-cell adhesion structure  involved in cell differentiation and tissue organization, is located in a SM-rich membrane lipid  domain. We have also demonstrated that under hypertonic conditions, MDCK cells acquire a  differentiated phenotype with changes in sphingolipid metabolism. For these reasons, we decided to  evaluate whether SM metabolism is involved in the acquisition of the differentiated phenotype of  MDCK cells. We found that SM synthesis mediated by SM Synthase 1 (SMS1) is involved in  hypertonicity-induced formation of mature AJs, necessary for correct epithelial cell differentiation.  Inhibition of SM synthesis impaired the acquisition of mature AJs, evoking a disintegration-like  process reflected by the dissipation of E-cadherin, &#946;- and &#945;-catenins from the AJ complex. As a  consequence, MDCK cells did not develop the hypertonicity-induced differentiated epithelial cell  phenotype.","palabras_clave":"SPHINGOMYELIN SINTHASE|RENAL EPITHELIAL CELLS|MDCK"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17495,"idioma_id":4,"titulo":"Transcriptional and translational mechanisms contribute to regulate the expression of Disc Large 1 protein during different biological processes","resumen":"Abstract  Human Disc large (DLG1) has been demonstrated to be involved in cell polarity and maintenance of tissue architecture. However, the mechanisms controlling DLG1 expression are not fully understood. This is relevant since DLG1 is lost during the later stages of malignant progression. We initiated a series of studies to analyze the mechanisms regulating DLG1 expression. We have previously reported the identification of an alternative splicing event in the 5? untraslated region (5´-UTR) of DLG1 mRNA that generates transcripts with two different 5?-UTR (short and large 5´-UTR variants). In this study, we further examined the impact of the DLG1 transcription and the role of the differential expression of the alternative 5´-UTRs on DLG1 protein levels. We analyzed these mechanisms during cell processes like differentiation, cell cycle progression and cell-cell contact formation, where the importance of DLG1 activities was previously established. The data presented in this report suggest that the transcriptional regulation of DLG1 strongly contributes to DLG1 abundance and that differential expression of alternative 5´-UTRs with different translational properties, also cooperates, depending on the cell type and cell situation. This study provides new evidence for understanding the transcriptional regulation of DLG1 and the changes in DLG1 expression during different biological processes.","palabras_clave":"DLG1|5'-UTR|TRANSCRIPTION REGULATION|POLARITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17497,"idioma_id":4,"titulo":"Synergetic effects of fire, climate, and management history on Prosopis caldenia recruitment in the Argentinean pampas","resumen":"Semiarid woodlands dominated by calden(Prosopis caldenia Burkart) thrive at the dry edge of the Argentinean Pampas.While the area of original woodlands shrinks due to deforestation, adjacentareas experience the advance of calden. The aim of this study was to determinethe factors that favoured recruitment of calden along its natural range and inadjacent grasslands and ecotone woodlands. Eight sampling sites were selectedin the original calden´s woodlands, in the grassland and in the ecotone.Standard dendrochronological techniqueswere applied to estimate establishment dates, date &#64257;re events and growthreleases. Recruitment of calden was massive and episodic. Two recruitmentevents were noticed in the woodland area in the 1790s and 1870s, whichcoincided, respectively, with the &#64257;rst settlement of aborigines and thegeneralised use of &#64257;re. Two periods with contrasted patterns of calden establishmentwere distinguished in the 20th century: 1920e1969 with an abundant recruitmentthat started with land abandonment by foreigner colonizers, and 1970e2010 withalmost no regeneration. Tree establishment was linked to &#64257;re. Sheep numbers hada positive effect on growth release of calden. Calden recruitment should beconsidered a multi-causal process that integrates the effects of several factorsmostly driven by anthropogenic land-use changes.","palabras_clave":"DENDROCRONOLOGÍA|BOSQUES|SEMIÁRIDO|FUEGO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17498,"idioma_id":5,"titulo":"INDUCCIÓN ORGANIZACIONAL O ENTRENAMIENTO OPERATIVO  EN LAS MIPYMES DE ALOJAMIENTO TURÍSTICO DE LA C.A.B.A.-ARGENTINA (2011-2013)","resumen":"Este estudio tuvo por objeto analizar la gestión del capital humano en las MiPyMEs de alojamiento turístico de la C.A.B.A. Específicamente, se analizaron los procesos de inducción en los cargos operativos de las organizaciones antes mencionadas. Por lo tanto, se desarrolló un estudio exploratorio-descriptivo con un enfoque analítico cualitativo a partir de entrevistar a los gestores de recursos humanos de los establecimientos de alojamiento turístico. Se detallan cada uno de los pasos, procedimientos y características del estudio, delimitando el ámbito del mismo, describiendo la fuente de información y el procedimiento de recolección de datos y, por último, explicando los instrumentos de medida y la diversidad de técnicas estadísticas utilizadas en el análisis de las hipótesis. Entre los principales resultados se observó que ha arrojado datos sumamente relevantes que permiten identificar prácticas y proyectar tendencias en los procesos de inducción de las organizaciones bajo análisis.","palabras_clave":"Inducción organizacional|Mipymes de alojamiento turístico|Gestión de recursos humanos|Entrenamiento operativo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17499,"idioma_id":4,"titulo":"Seed production and recruitment in primary and harvested Nothofagus pumilio forests: Influence of regional climate and years after cuttings","resumen":"Aim of study:Harvesting proposals (e.g. variable retention) for Nothofagus pumilio forestsare based on canopy opening, to increase recruitment and enhance seedlinggrowth, by modifying light and soil moisture. Seed production and seedlingrecruitment will define the success of harvesting, where remnant foreststructure are the main influence factors, as well as biotic and abiotic factors.The objective was to analyse seed production, seedling recruitment andrecruitment efficiency in primary and harvested forests throughvariable retention along the first 10 years after harvesting, as well as theinfluence of regional climate.Area of study: Thestudy were conducted in a pure Nothofagus pumilio forest located in centralTierra del Fuego (54°18? S, 67°49? W), where harvested stands with variableretention and unmanaged forests were sampled in long-term permanent plots.Material and methods:Data of forest regeneration plots were used (n = 72) (2007 a 2014), and foreststructure and seed production (2006 a 2013) were also measured. Regional climate wascharacterised for these years from satellite images (Sea Surface Temperature)and climate re-analysis models (rainfall and temperature of land surface).Main results:Harvesting modified forest structure; however, aggregated retention maintainedsome characteristics of the primary unmanaged forests. These changes influencedseed production and recruitment. Seed production and recruitment were related tocrown cover and the amount of seed production; however, recruitment efficiencywas not affected by harvesting. The studied variables significantly changedalong the years after harvesting. Seed production and recruitment were alsorelated to regional climate factors, where it was possible to explain theirvariations through temperature (e.g. summer temperature) and rainfall (e.g. winterrainfall) for the different retention types in harvested forests and theprimary forests.Research highlights:Variable retention harvesting generated different micro-conditions thatinfluence seed production and recruitment. These variables were related tocanopy cover. However, recruitment efficiency was not affected by harvesting.Seed production and recruitment (primary forests and harvested stands) wererelated to regional climate factors and their variations can be explained fromvariables related to temperature and rainfall.","palabras_clave":"REGENERATION|FOREST MANAGEMENT|CROWN COVER|REGIONAL CLIMATE|MODELLING|TIERRA DEL FUEGO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17500,"idioma_id":5,"titulo":"Estrategias de Articulación entre el nivel medio y la Universidad. Curso 'Me preparo para estudiar ingeniería'","resumen":"Numerosos factores inciden en la deserción temprana y el mal desempeño de los estudiantes en los primeros cursos de la universidad. Las dificultades que tienen los alumnos ingresantes en cuanto a la falta de formación y escasez de conocimientos de ciertos temas, sumadas a la notable heterogeneidad  de orientaciones en la formación de los alumnos ingresantes a las carreras de Ingeniería, producen un desgranamiento importante. El trabajo articulado entre el Nivel Medio y la Universidad apunta a mejorar las condiciones de los aspirantes a ingresar en alguna de las carreras de Ingeniería de la Universidad  Nacional de Salta (UNSa). El objetivo principal es mejorar su rendimiento en los primeros pasos de la carrera, tratando de acortar la brecha entre el nivel medio y el universitario. Por eso, desde la Universidad se han puesto en práctica diferentes estrategias a lo largo de los años, siendo una de ellas el dictado de un curso llamado 'Me preparo para estudiar Ingeniería', especialmente diseñado para alumnos del último año de la Escuela Media que aspiran a ingresar a la Facultad de Ingeniería de la UNSa. En el siguiente trabajo se analizan algunos indicadores para medir el impacto del curso, tales como el rendimiento de los  estudiantes en el examen final, el aumento en la retención y la respuesta de los alumnos. Los resultados reflejan una mejora y son alentadores para seguir implementando estrategias para optimizar la articulación entre ambos niveles.","palabras_clave":"Articualcion|Organizadores Previos|Ingreso a la Universidad|Aprendizaje Significativo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17501,"idioma_id":4,"titulo":"Steam reforming of glycerol: Hydrogen production optimization","resumen":"The glycerol steam reforming reaction was studied using Pt-based catalysts in order to selectively produce hydrogen. The global steam reforming reaction is the combination of two consecutive steps: i) glycerol decomposition and ii) water gas shift reaction (WGS).  Pt supported over solids with markedly different physicochemical properties (SiO2, MgO, Al2O3 and TiO2) were prepared and tested in steam reforming reaction of glycerol (10% wt. aqueous solution) at 573e623 K. Glycerol to gas products conversion of 100% and hydrogen yield of 78.8% were obtained by using Pt over an inert support (Pt\/SiO2 prepared from chlorine-free solution). Acidic supports favored undesirable reactions conducting to liquid products and coke precursors. Furthermore, WGS reaction was studied at reaction conditions compatible with steam reforming over Pt\/SiO2, Pt\/TiO2 and two catalysts prepared for that purpose: Pt\/CeO2 and Pt\/ZrO2. Pt\/TiO2 showed the highest CO conversion at 623 K. In order to maximize H2 formation, a double-bed catalytic system (0.5% wt. Pt\/SiO2 þ 0.5% wt. Pt\/TiO2) was used achieving a 100% hydrogen yield without deactivation on stream.","palabras_clave":"Steam reforming|Hydrogen|Water Gas Shift reaction|Pt catalyst"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17502,"idioma_id":5,"titulo":"Producción de alimentos y diferenciación social en el Valle de Ambato, Catamarca, Argentina (siglos VI al XI d. C.). Una contribución a la problemática a través del estudio de silicofitolitos d.C.","resumen":"En este artículo se presenta la información obtenida de los estudios fitolíticos efectuadosen el sedimento de dos estructuras agrícolas prehispánicas,&nbsp; situadas en la vertiente occidental del Valle de Ambato, Catamarca, Argentina. Los trabajos realizados se focalizaron en tratar de determinar las especies vegetales cultivadas y en evaluar laimportancia que pudieron tener estos cultivos en un contexto social no igualitario como el registrado en la región estudiada. Los resultados logrados permiten plantear que en dichas estructuras se practicó el cultivo exclusivo de maíz (Zea mays) asociado a la cría de animales domésticos (Lama glama). La producción intensiva y localizada de este tipo de cultivo, en un contexto como el de Aguada de Ambato, signado por una desigualdad social creciente, pudo haber constituido una de las estrategias a la hora de establecer y reproducir en el tiempo relaciones no igualitarias.","palabras_clave":"MICRORRESTOS|SILICOFITOLITOS|ESTRUCTURAS AGRICOLAS|VALLE DE AMBATO|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17503,"idioma_id":4,"titulo":"Evaluation of an organic waste composting device to household treatment","resumen":"The performance of a plug-flow automated aerobic digester used with the compost of the Biodegradable Organic Waste (BOW) from a typical family at its generation rhythm was evaluated. During a 13 month assessment, 179.7 kg of BOW were treated and 106.7 kg of compost were obtained with a C:N ratio of 12 and an average concentration of N of about 2.72%. Additional tests enabled to assess the generation of stable and good quality compost according to the considered standards, suitable for using as organic fertilizer and other uses, such as biotreatments. The design, location and operational characteristics of the device have determined reduced leachate emissions, the absence of unpleasant odour generation and incidence of insects or other vectors, implying the viability of their use without affecting the user´s life quality. It could be an efficient alternative treatment for household BOW, from a technical, economic, energy, cultural and environmental point of view, easy to implement for users lacking in special training.","palabras_clave":"Automated aerobic digesters|Household waste treatment|Composting|Plug-flow Biodigester."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17504,"idioma_id":4,"titulo":"Toxicity of the insecticide chlorpyrifos to the South American toad Rhinella arenarum at larval developmental stage","resumen":"Chlorpyrifos (CPF) is an insecticide widely used for pest control in the   fruit-productive region of North Patagonia, Argentina, where it is   found in superficial waters. The aim of this study was to establish the   toxic effects of CPF in Rhinella arenarum toad larvae as a potentially   exposed species. We determined the 96h-LC50 (1.46 ± 0.27 mg\/L), the LOEC   (0.81 mg\/L, LC10) and NOEC (0.43 mg\/L, LC1) for CPF lethality as   endpoint. We also analyzed biochemical biomarkers in larvae exposed to   sublethal CPF concentrations. The IC50 for cholinesterase was   0.113±0.026 mg\/L, one order of magnitude lower than the LC50.   Carboxylesterase activity was inhibited, buffering OP toxicity on   cholinesterase. Reduced gluthatione increased after 24 h as an   antioxidant response, and decreased at 96 h together with catalase   activity, due to oxidative stress. These biochemical effects suggest   that environmentally relevant CPF concentrations pose a threat to R.   arenarum larvae progression.","palabras_clave":"Amphibians|Organophosphates|Biomarkers|Cholinesterase"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17505,"idioma_id":4,"titulo":"Novel Augmented Parallel Factor Model for Four-Way Calibration of High-Performance Liquid Chromatography-Fluorescence Excitation-Emission Data","resumen":"A new augmented parallel factor analysis model (Augmented PARAFAC) is presented, inspired in the useful augmentation concept employed in multivariate curve resolutionalternating least-squares (MCR-ALS), applicable to calibration based in non-quadrilinear fourway data, such as those produced by the high-performance liquid chromatography with matrix excitation-emission fluorescence detection. The new model involves creating an augmented three-way array in the elution time direction, containing data for the calibration sample set and for each of the test samples, subsequently analyzed with an Augmented PARAFAC version. To test the properties of this approach, chromatographic data were simulated with several different degrees of overlapping and misalignment among the chromatographic peaks. Additionally, experimental data from olive oil samples were tested with the new model, aimed at the quantitation of the level of chlorophylls and pheophytins. The results were compared with those obtained by data processing with MCR-ALS. Relative prediction errors (%) were: Augmented PARAFAC, 9.7, 21.0, 14.7 and 9.3, MCR-ALS, 5.9, 14.5, 20.0 and 14.7 for Chl a, Chl b, Phe a and Phe b, respectively, for concentrations in the range 0.00-1.00 µg mL-1. Both MCR-ALS and Augmented PARAFAC allow one to obtain a detailed and realistic description of the analyzed samples, in terms of pure elution time, excitation and emission spectral profiles, which can be independently retrieved for every component.","palabras_clave":"LIQUID CHROMATOGRAPHY-EXCITATION-EMISSION FLUORESCENCE DATA|MULTI-WAY CALIBRATION|AUGMENTED PARALLEL FACTOR ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17506,"idioma_id":5,"titulo":"Optimization of traditional systems of liquid effluent treatment to reduce environmental impact: Combination with biodiscs technologies for reuse of treated water","resumen":"In the city of Córdoba and the surrounding mountain towns, increased population density, the development of industry and the promotion of tourism was an increase in demand for drinking water and wastewater generation. A high percentage of homes and small developments are not connected to the sewerage network and used in-situ systems to treat and disposal as septic tank effluent, seepage pits or indentations systems. Due to low yields documented this system of treatment, dragging ineffectively treated water leach toxic substances that pollute the groundwater. Besides this consolidation process precludes their reuse for other activities. To reduce the environmental impact the implementation of non-traditional technologies to be combined with existing conventional treatment systems, aim of this work is decided. It was designed and installed a treatment plant which includes as a first step the existing septic tank followed by an anaerobic settler and an aerobic biological biodiscs module and a storage and chlorination tank. To check the efficiency of the system, samples at three points along the plant (n = 78) and three internal stages of biodiscs (n = 27) were taken. In-situ and laboratory analysis, involving physicochemical and microbiological determinations, were made. The result was the reduction of the organic content present in the effluent (BOD5 beginning versus end of treatment p &lt;0.05) and much of the inorganic content allowing remediated water reuse for irrigation of green areas of the property. The proposed of integration of non-traditional technologies to existing model is an ecological and sustainable option as it improves the efficiency of treatment and allows the reuse of treated water, cooperating with the environment.","palabras_clave":"COMBINACION DE TECNOLOGIAS|REMEDIACION|REUTILIZACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17507,"idioma_id":5,"titulo":"Tumor ovárico semejante a tumor de células epitelioides perivasculares (PEComa) en boga (Leporinus obtusidens)","resumen":"Las neoplasias ováricas en teleósteos son escasamente mencionadas, existiendo más frecuencia de reportes en ejemplares de especies ornamentales. En este trabajo se describe por primera vez las características de un tumor espontáneo de ovario en un ejemplar de adulto de boga (Leporinus obtusidens) obtenido del río Paraná. Macroscópicamente, en la cavidad abdominal y en correspondencia al tercio posterior del ovario se observó una deformación irregular encapsulada de consistencia firme y aspecto quístico, con adherencias entre la membrana ovárica y el peritoneo dorsal. Muestras del tumor y de tejido ovárico fueron fijadas en formol (10%) e incluidas en parafina, obteniéndose cortes de 3 micrómetros de espesor, que se colorearon con técnicas de rutina, histoquímica e inmunohistoquímica. La observación histopatológica del tejido tumoral reveló estructuras quísticas y tejido tumoral proliferante. Las estructuras quísticas presentaron material amorfo en su interior y se encontraron delimitadas por un revestimiento celular de aspecto epitelioide. El tejido tumoral proliferante presentó un aspecto pleomórfico, hallándose zonas de tejido conectivo mixoide con células fusiformes y abundantes capilares, áreas de tejido mucoide y células poligonales cercanas a los capilares dispuestas aisladas o formando islotes. Las células poligonales presentaron citoplasma eosinófilo y núcleos grandes con cromatina laxa y nucléolos evidentes, observándose algunas figuras mitóticas. Estas células proliferaron formando un tejido de aspecto epitelioide con capilares intercalados, adoptando un aspecto esponjoso en la periferia de algunos vasos con una importante trama de fibras reticulares. Además, se observaron delgadas fibras colágenas e infiltrado inflamatorio en la zona más externa del tejido. Por analogía con los tipos descriptos en mamíferos, se puede establecer que la lesión observada en ovario de boga corresponde a un tumor de origen mesenquimático, con una morfología que se asemeja a la de los tumores de células epitelioides perivasculares (PEComa)","palabras_clave":"LEPORINUS OBTUSIDENS|OVARIO|PECOMA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17508,"idioma_id":4,"titulo":"Evaluation of Italian all-male asparagus (Asparagus officinalis L.) hybrids and seedling sizes as strategies to optimize green spear production in Argentina","resumen":"Asparagus is a delicious vegetable crop with a positive growing trend worldwide and the demand of product is is concentrated in the Northern Hemisphere; therefore, the Southern Hemisphere countries supplying  counter-season production have the chance to increase the exportation. Since in this species a great interaction between the genotype of selected variety and the cultivation environment,  it is important to evaluate the behaviour of the different hybrids available at international level. At present in Argentina the most cultivated hybrid is UC-157, showing 1\/1 female\/male plant ratio, but all-male hybrids giving  more uniform spears are also available. A second important aspect to be considered is the propagation material that can be distinguished in seedling grown in plastic multiport and one-year old crown. In Argentina seedlings are preferred to crowns. Therefore  the identification of hybrid and seedling size able to maximize the grower income were the main objectives of this research work.  The all-male hybrids Italo, Zeno, Eros, Ercole, H668, Marte and Giove bred in Italy and the control test UC-157 from USA were evaluated in a field trial. One hundred-day seedlings grown in multipots with 70 or 100 cm3 were used as multiplication material. The trial was established in Azul, Buenos Aires , Argentina on 22\/11\/2006 following a random block design with four replicates and ?.. plants per plot. . The harvest period evaluated was 19\/09\/2011-09\/11\/2011 , using a frequency of every other day. The trial was a. A statistical analysis of all the variables was performed by means of ANOVA-LSD test (P>0.05).   An average commercial productivity of 15.5t.ha-1 was obtained whereas the total production was 9t.ha and 486237 total turions and 397515 commercial turions. Concerning the behavior of the different hybrids, differences in net fresh weight were obtained with an average of 8.4t.ha-1, highlighting H668 followed by Zeno, Eros and Ercole. With respect to calibers, in Jumbo, Giove stood out, whereas, in Extra Large the male hybrids surpassed UC-157.  On the other hand, in Large, Medium and Small UC-157 stood out. Concerning the size of seedlings used, the results show the convenience of planting with big size seedlings, since they allow the obtaining of 8.6t.ha-1, whereas with a small size: 8.1t.ha- 1. In short, the choice of the initiation organ and the hybrid are aspects of vital importance for the success of this productive alternative.","palabras_clave":"SEEDLING SIZE|PRODUCTION|QUALITY|SPEAR DIAMETER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17509,"idioma_id":5,"titulo":"Tendencias de mortalidad por cáncer de mama en Córdoba (Argentina) 1986-2011, algunas interpretaciones sociohistóricas","resumen":"Objetivo. Analizar e interpretar las tendencias de mortalidad por cáncer de mama (CM) en las últimas décadas en la provincia de Córdoba, Argentina, en función de los cambios demográficos y características del contexto sociopolítico.Métodos. Se calcularon tasas de mortalidad por CM crudas, estandarizadas (método directo) y específicas por edad, para Córdoba, en el período 1986?2011. Mediante la aplicación RiskDiff®, se analizó la variación observada en las tasas crudas entre 1986 y 2011. Se ajustaron modelos de regresión Joinpoint® a las tasas estandarizadas y específicas por grupos etarios. Se consultaron fuentes de datos secundarias (leyes, decretos, programas de salud) para obtener información sobre el contexto sociopolítico del período estudiado.Resultados. La tasa cruda de mortalidad por CM aumentó 24,97% entre 1986 y 2011, siendo esto atribuible a un aumento del riesgo de morir (5,22%), a cambios en la estructura (19,75%) y al tamaño poblacional (39,66%). La tasa estandarizada de mortalidad por CM presentó tendencia creciente hasta 1996 (porcentaje de cambio anual [PCA] = 1,62%; P &lt; 0,05), y luego comienza a descender (PCA = ?2,1%; P &lt; 0,05), advirtiéndose una desaceleración alrededor del año 2001. Para las interpretaciones sociohistóricas, se consideraron como ejes de análisis las transiciones demográfica, epidemiológica y sanitaria, así como hechos socioeconómicos y políticos del período estudiado.Conclusiones. El comportamiento de la mortalidad por CM en este período se asocia a factores de índole contextual (demográficos, históricos, económicos, políticos). Los resultados de este trabajo contribuyen a definir acciones y políticas en torno la problemática del CM y en materia del cuidado de salud de las mujeres.","palabras_clave":"SALUD DE LA MUJER|TASAS DE MORTALIDAD|NEOPLASIAS MAMARIAS|CÓRDOBA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17510,"idioma_id":4,"titulo":"Experimental and theoretical study of the photoisomerization and thermal reversion of 5-benzylidene-thiohydantoin cis\/trans isomerization","resumen":"zzzzzz","palabras_clave":"Fotoisomerización|tiohidantoínas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17511,"idioma_id":4,"titulo":"TD-DFT calculations of absorption bands and their intensities in the UV spectra of some tetrahydroquinolines","resumen":"zzzzz","palabras_clave":"DFT cálculos|Espectros UV|tetrahydroquinolinas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17512,"idioma_id":4,"titulo":"Improving initial trials in tree breeding using kinship and breeding values estimated in the wild: the case  of Prosopis alba in Argentina","resumen":"Most Argentinean forests have been lost by over exploitation and expansion of agricultural areas. The National breeding program for the native species Prosopis alba is still in its initial phase with only a few progeny trials installed from material collected in the wild and the first genetic studies are underway. Breeding value (BV) estimates based on pedigree data from a progeny trial were first compared to those derived by using microsatellite based kinship estimates to confirm the potential accuracy of g-best linear unbiased predictions (G-BLUP) when pedigree information is lacking. Afterwards, the possible genetic effects of alternative selection strategies to collect improved seeds from a wild population were evaluated. To achieve this goal the relationship among average genetic gain (predicted by G-BLUP), inbreeding and sampling size of the collected materials were weighed in a wild population consisting of trees of similar ages. The results obtained suggest that kinship estimates based on molecular data and breeding value predictions BV used for the selection of elite trees in wild populations may contribute to improve the genetic properties of the founder population. Controlling kinship allows reducing sampling size from 20 to 10 individuals per origin with no significant increase of inbreeding or loss of genetic gain. For a selected group of only ten top individuals per origin, the replacement of two strongly reduces the average group coancestry with minimal gain loss. Simultaneous selection for two traits by selection index might produce a gain of near 6 % in height and 2 % in diameter. The use of molecular marker information may contribute to reduce the time needed in a P. alba improvement program.","palabras_clave":"BLUP|BREEDING PROGRAM|BREEDING VALUE|COANCESTRY|MICROSATELLITES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17513,"idioma_id":4,"titulo":"Pathology and diagnosis of proliferative and ulcerative dermatitis associated with Tunga penetrans infestation in cattle","resumen":"        Tunga penetrans is the smallest biting flea known. In cattle, infestation by T. penetrans (tungiasis) typically        affects the skin of the distal legs, udder, prepuce, and perianal area. A detailed clinical and pathologic description of bovine        tungiasis, together with electron microscopy and molecular diagnostics to establish the identity of the parasite are described.        Ninety percent of the cows and heifers and 80% of the bulls in a herd in northwest Argentina had proliferative and ulcerative        skin lesions affecting the coronary band, interdigital space, heels, and rudimentary toes of the fore and\/or rear limbs, teats, and\/        or prepuce. These proliferative lesions had multiple large cavities filled with hemorrhagic fluid, necrotic debris, and Tunga spp.        parasites. Histologically, the skin showed diffuse papillary epithelial hyperplasia with severe orthokeratotic hyperkeratosis,        and it was multifocally ulcerated and inflamed. Multifocally, sections of arthropod parasites were observed embedded in the        epidermis and dermis with the posterior end toward the surface. Images of wet mounts and scanning electron microscopy of the        parasite showed morphologic characteristics compatible with Tunga spp. Polymerase chain reaction followed by sequencing        of the cytochrome c oxidase subunit II and the internal transcribed spacer region indicated 99% homology to published        T. penetrans sequences. Tungiasis should be considered as a differential diagnosis for proliferative lesions in skin of cattle.","palabras_clave":"Tunga penetrans|Bovine|Dermatitis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17514,"idioma_id":5,"titulo":"Evaluación del crecimiento micelial de Pleurotus ostreatus y Agrocybe aegerita sobre orujos de pera","resumen":"El objetivo de este trabajo fue evaluar la capacidad de tres cepas  de Pleurotus ostreatus y una de Agrocybe aegerita para colonizar  la biomasa generada por las industrias jugueras (orujo) y comparar  las curvas de crecimiento micelial. El aprovechamiento de estos residuos  lignocelulósicos permitiría brindar opciones para la disposición  final de esta biomasa residual. Como sustratos se emplearon  dos tipos de orujos de pera, uno sometido a un tratamiento enzimático  previo a la extracción de jugo y otro sin tratar. A. aegerita  evidenció menor crecimiento que P. ostreatus en ambos sustratos,  mientras que P. ostreatus presentó mejor desarrollo sobre el orujo  con pretratamiento enzimático, comportamiento que podría estar  relacionado con la composición química de los orujos de pera analizados.","palabras_clave":"Hongos comestibles|Fermentación en fase sólida|Velocidad de crecimiento|Sustratos lignocelulósicos|Deshechos agroindustriales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17515,"idioma_id":5,"titulo":"Contribución al conocimiento de la anatomía foliar de Mnesithea selloana (Hack.) de Koning & Sosef (Andropogoneae-Panicoideae-Poaceae)","resumen":"El objetivo del presente trabajo fue analizar&nbsp; la anatomía foliar en sección transversal de&nbsp; lámina y en vista superficial de epidermis de Mnesithea selloana. Se realizaron transcortes y preparados epidérmicos de la parte media de hojas de innovaciones estériles los cuales se acondicionaron, se observaron con microscopio óptico (MO) y microscopio electrónico de barrido (MEB), se dibujaron con cámara clara y se fotografiaron con una cámara de fotos MotiCAM 2000 Motic Images Plus 2.0ML. Las características histofoliares observadas fueron: células epidérmicas, intercostales, subsidiarias, suberosas, silíceas y buliformes; además estomas, pelos, ceras, mesofilo, vaina Kranz, haces vasculares, esclerénquima, parénquima incoloro y margen de la hoja. Las observaciones realizadas a nivel epidérmico manifestaron que M. selloana presenta una epidermis&nbsp; de tipo panicoideo presentando células silícicas en forma de doble hacha, células epidérmicas más largas que anchas, con paredes anticlinales sinuosas, estomas con células subsidiarias triangulares y micropelos bicelulares. En transcorte la estructura anatómica foliar coincide con lo descripto para el tipo panicoideo con la diferencia que M. selloana presenta el clorénquima dispuesto en una sola serie alrededor de los haces vasculares presentando en algunos casos una serie adicional que actúa de unión entre ellos y no presentó vaina mestomática en los haces de primer orden.","palabras_clave":"Mnesithea selloana|Anatomía foliar|Características"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17516,"idioma_id":4,"titulo":"Development of a Catalogs System for Augmented Reality Applications","resumen":"                              Augmented Reality is a technology that involves the overlay of virtual  content, which is context or environment sensitive, on images of the physical  world in real time. This paper presents the development of a catalog system  that facilitates and allows the creation, publishing, management and  exploitation of augmented multimedia contents and Augmented Reality  applications, creating an own space for anyone that wants to provide  information to real objects in order to edit and share it then online with  others. These spaces would be built for different domains without the initial  need of expert users. Its operation focuses on the context of Web 2.0 or Social  Web, with its various applications, developing contents to enrich the real  context in which human beings act permitting the evolution of catalog?s  contents in an emerging way.                              &nbsp;                                ","palabras_clave":"Augmented Reality|Catalog System|Computer Graphics|Mobile Application"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17517,"idioma_id":5,"titulo":"Análisis de diversidad de la familia Poaceae en la región austral de América del Sur","resumen":"La familia Poaceae es una de las mejor representadas en América del Sur   austral, con un total de 206 géneros que comprenden 1523 especies   distribuidas en 10 subfamilias diferentes. En este trabajo analizamos la   distribución de estos grupos en Argentina, sur de Brasil (Paraná, Rio   Grande do Sul y Santa Catarina), Chile, Paraguay y Uruguay; discutimos   la riqueza de las diferentes subfamilias, tribus y géneros, su   distribución, especies endémicas, la relación de especies anuales y   perennes, así como el número de especies Kranz y no Kranz, su abundancia   según regiones geográficas, en relación con la temperatura y las   precipitaciones, géneros disyuntos, y la proporción de taxones en   relación con las diferentes ecorregiones del área","palabras_clave":"DIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17518,"idioma_id":4,"titulo":"CD4+ Foxp3+ Regulatory T Cells in Autoimmune Orchitis: Phenotypic and Functional Characterization","resumen":"Problem  The phenotype and function of regulatory T (Treg) cells in rats with  experimental autoimmune orchitis (EAO) was evaluated.  Method of study  Distribution of Treg cells in draining lymph nodes from the testis (TLN) and from the site of immunization (ILN) was analysed by immunohistochemistry.  The number, phenotype and proliferative response 5-bromo-20-deoxyuridine incorporation) of Treg cells were evaluated by flow cytometry and Treg cell suppressive activity by in vitro experiments.TGF-b expression was evaluated by immunofluorescence.  Results  Absolute numbers of Treg cells and BrdU+ Treg cells were increased in LN from experimental compared to normal and control rats. These cells displayed a CD45RC-, CD62L-, Helios+ phenotype. CD4+ CD25bright T cells from TLN of experimental rats were able to suppress T cell-proliferation more efficiently than those derived from normal and control rats. Cells isolated from TLN and ILN expressed TGF-b.  Conclusion  Our results suggest that Treg cells with a memory\/activated phenotype proliferate extensively in the inflamed testis and LN of rats with EAO  exhibiting an enhanced suppressive capacity. TGF-b may be involved in  their suppressive mechanism.","palabras_clave":"IMMUNOREGULATION|INFLAMMATION|TESTIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17519,"idioma_id":5,"titulo":"APORTES PARA LA MEDICION DEL VALOR AÑADIDO POR EL TURISMO. El turismo residencial estival en las mediciones del Producto Bruto Geográfico del Partido de General Pueyrredón, Argentina","resumen":"      La ciudad de Mar del Plata, Provincia de Buenos  Aires, Argentina, presenta una estructura económica vinculada a su evolución  como centro turístico, desde inicios del siglo XX. La estimación local del  Producto Bruto Geográfico, confirma la importancia del turismo de sol y playas, en la  organización productiva de  la ciudad. &nbsp;      De  acuerdo a las estadísticas locales, el hospedaje de turistas en la ciudad, se orienta  al denominado turismo residencial, el cual refiere  al realizado en viviendas, principalmente en verano. Esta particularidad queda  oculta en las clasificaciones tradicionales del Producto Bruto ya que no se  mide expresamente la magnitud de su aporte económico. El objetivo de este  trabajo es presentar las características de este alojamiento y una estimación  de su contribución económica, mediante el valor agregado generado en las temporadas  de verano de 2004 y 2010.      Se emplearon fuentes secundarias, encuestas y  entrevistas en profundidad y entre los principales resultados se estimó que el  turismo residencial en temporada  estival, aportó 78 millones de pesos en 2004 a la economía local. Hacia 2010, dicho  guarismo se incrementó en un 40%, a valores constantes. El escrito contribuye a ampliar el conocimiento sobre  el rédito económico de la actividad turística receptiva local y cubre un área  de vacancia destinada a autoridades y oferentes de servicios turísticos para la  formulación y el fortalecimiento de políticas públicas y privadas.  ","palabras_clave":"TURISMO RESIDENCIAL|VALOR AGREGADO|GENERAL PUEYRREDON"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17520,"idioma_id":4,"titulo":"Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis","resumen":"Study question: Does high mobility group box protein 1 (HMGB1) regulate inflammatory reactions in a rat model of experimental autoimmune  orchitis (EAO)?  Summary answer: HMGB1appears to be involved in regulating inflammatory reactions in testes, asHMGB1is translocated fromtesticular  cells during the course of EAO and blocking its action by ethyl pyruvate (EP) reduces disease progression and spermatogenic damage.  What is known already: Despite its immune privileged status, the human testis is prone to inflammatory lesions associated with male  factor infertility. Accumulating evidence shows that HMGB1 plays an important role in onset and progression of autoimmune diseases.  Study design, size, duration: This is a cross sectional and longitudinal study involving Wistar male rats immunized with testicular  homogenates to induce EAO50 (EAO50; n ¼ 10) and 80 (EAO80; n ¼ 10) days after first immunization. Control adjuvant animals received saline  instead of testicular homogenate (n ¼ 16). Untreated animals (n ¼ 10) were also studied. An interventional study was performed to block the  action of HMGB1 starting 20 days after first immunization in EAOanimals and respective controls (n ¼ 17). Rats were treated i.p. with EP and the  effect of EP treatment on testicular pathogenesis was evaluated 30 days later. Moreover, human testicular biopsies from infertile men with focal  lymphocytic infiltrates (n ¼ 7) and sections with intact spermatogenesis (n ¼ 6) were probed with antibodies against HMGB1.  participants\/materials, setting, methods: Testicular RNA and protein extracts from EAOanimals, EAO animals treated with EP and relevant controls were used for analysis of cytokine expression by real-time RT?PCR and enzyme-linked immunosorbent assay. HMGB1 was co-localized on rat testicular cross sections with antibodies against testicular macrophages (TM), peritubular cells (PTC) and Sertoli cells (SC). Interaction of HMGB1 and its receptors (RAGE, TLR4) as well signaling pathways after HMGB1 stimulation were studied in  isolated TM, PTC and SC by proximity ligation assay and western blot, respectively. Furthermore, HMGB1 immunofluorescence on human  testicular biopsies was performed.  Main results and the role of chance: HMGB1 was translocated from the nuclei in EAO testes and testes of infertile men with impaired spermatogenesis and lymphocytic infiltrates. Elevated HMGB1 levels were observed during late phase of EAO. In testicular somatic cells HMGB1 receptors Toll-like receptor 4 (TLR4) and receptor for advanced glycation end products (RAGE) were differentially expressed: HMGB1-TLR4 binding was predominant in TM, while HMGB1-RAGE interaction was prevalent in SC and PTC. In support,HMGB1 triggered extracellular signal regulated kinase (ERK)1\/2 and cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) activation in SC and PTC, while TM responded to HMGB1 stimulation with p38 mitogen-activated protein kinase (MAPK)  and p65 nuclear factor Kappa B (NF-kB) phosphorylation followed by increased tumor necrosis factor a (TNF-a) and interleukin 6 (IL-6)  mRNA levels. In vivo treatment of EAO animals with EP 20 days after induction of disease revealed beneficial effects, as documented by  reduced disease progression and spermatogenic damage, lower macrophage numbers, as well as decreased concentrations of HMGB1 and IL-6 in the testis compared with EAO controls.  Limitations, reasons for caution: The ability of HMGB1 to bind to a wide range of receptors makes it difficult to prevent its action by blockade of a specific receptor; therefore we applied EP, a drug preventing HMGB1 release from cells. Due to its mode of action EP decreases also the secretion of some other pro-inflammatory cytokines. Using isolated primary cells imposes limitations for cell transfection studies. As a compromise between purity and yield primary cells need to be isolated from animals of different age, which has to be considered when comparing their responses.  Wider implications of the findings: HMGB1 could be a promising target in attenuating testicular damage caused by inflammatory reactions.","palabras_clave":"TESTICULAR INFLAMMATION|EXPERIMENTAL AUTOIMMUNE ORCHITIS|HIGH MOBILITY GROUP BOX PROTEIN 1|RECEPTOR FOR ADVANCED GLYCATION AND PRODUCTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17521,"idioma_id":5,"titulo":"Magnitudes dendrométricas de cuatro poblaciones de Algarrobo Blanco  (Prosopis alba) de diferentes edades","resumen":"Magnitudes dendrométricas fueron analizadas en cuatro poblaciones de Prosopis alba (algarrobo blanco) con diferentes edades dentro de las regiones fitogeográficas del Espinal y Parque Chaqueño.  Las variables cuantitativas medidas fueron: diámetro, altura total, altura de fuste y ancho de copa; los caracteres cualitativos observados fueron: rectitud, sanidad de fuste y vitalidad de copa.  El mayor incremento anual de diámetro y altura total se observó en una población cultivada de 8 años.  El diámetro y la altura entre poblaciones mostraron diferencias estadísticamente significativas, la correlación entre estas magnitudes mediante una ecuación potencial mostró un coeficiente satisfactorio (R2 = 0.92) cuando se analizaron las cuatro poblaciones en conjunto.  El ancho de copa fue la variable que mejor correlación presentó con el diámetro y la altura total en árboles del bosque nativo con más de 25 años de edad; esta población presentó además la mayor altura del fuste aunque la misma creció sin ningún tipo de conducción, esto se debió a la extracción de ramas basales para usos varios aunque sin la debida planificación, lo cual no asegura la obtención de un fuste adecuado.           La curvatura del eje principal encontrada en plantas de un año es un carácter inherente a la especie, la cual se condice con la arquitectura vegetal de P. alba ya que presenta el modelo arquitectural de Troll.    Las mejores características cualitativas se observaron en las poblaciones cultivadas.  La utilización de plantas jóvenes permitió tener valores del extremo inferior de las curvas de crecimiento, mientras que los datos del bosque nativo favorecieron el análisis de árboles de mayores dimensiones.  Es necesario ampliar la cantidad de individuos de diferentes poblaciones para obtener ecuaciones más precisas de P. alba.","palabras_clave":"DENDROMETRIA|DIFERENTES|EDADES|ALGARROBO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17522,"idioma_id":4,"titulo":"Legitimizing leadership: Argentine President Cristina Fernández de Kirchner?s 2007 inaugural address","resumen":"In this essay, I examine how Argentine president Cristina Fernández de Kirchner used her 2007 inaugural address to legitimize her political leadership. Placing the address within Argentina?s political climate and working in light of the fact that Fernández de Kirchner?s spouse was the out-going president, I use theories of political ethos to examine the challenges Fernández de Kirchner faced in inaugurating her presidency. I suggest that she constructed a hybrid ethos, combining multiple presidential images to reconcile competing concerns. I treat in-depth three elements of that hybrid ethos: the ethos of a presidential couple that positioned Fernández de Kirchner alongside her popular husband; the ethos of a woman president building on a tradition of other influential Argentine women; and the ethos of a teacher-expert whose knowledge authorized national leadership. Enacting these varied ethoi, I argue, Fernández de Kirchner turned political challenges to her advantage and crafted the presidency she would assume.","palabras_clave":"LEADERSHIP|LEGITIMATION|PRESIDENTIAL RHETORIC|CRISTINA FERNÁNDEZ DE KIRCHNER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17523,"idioma_id":4,"titulo":"Effect of Lactobacillus johnsonii CRL1647 on different parameters of honeybee colonies and on defined culturable bacterial populations of bee gut","resumen":"Lactobacillus johnsonii CRL1647, isolated from the intestinal tract of a worker-bee in Salta, Argentina, was delivered to Apis mellifera L. honey bee colonies according to two different administration schedules: 1x105 cfu\/mL every 15 days (2011) or monthly (2012). The effect of each treatment on the bee-colony performance was monitored by measuring honey production, and the prevalence of varroasis and nosemosis. Worker bees from each assay were randomly captured 3 days after administration and assayed for the following intestinal culturable and defined bacterial populations: total aerobic microorganisms, Bacillus spp. spores, Lactobacillus spp., Enterococcus spp. and Enterobacteria.   Interestingly, both treatments generated a similar increase in honey production in treated colonies when compared with controls: 36.8% (every 15 days) and 36.3% (monthly). Nosema index always exhibited a reduction when lactobacilli were administered; in turn, Varroa incidence was lower when the lactobacilli were administered once a month. Moreover, the administration of L. johnsonii CRL1647 every 15 days produced an increase in the total number of aerobic microorganisms and in bacteria belonging to the genera Lactobacillus and Enterococcus; at the same time, a decrease was observed in the number of total spores at the end of the treatment. The number of enterobacteria was constant and remained below that of control hives at the end of the assay. On the other hand, the delivery of lactobacilli once a month only showed an increase in the number of bacteria belonging to the genus Lactobacillus; meanwhile, viable counts of the remaining microorganisms assayed were reduced. Even though it seems that both treatments were similar, those bee colonies that received L. johnsonii CRL1647 every 15 days became so strong that they swarmed.","palabras_clave":"honeybee|Apis mellifera|probiotic effect|honey yield"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17524,"idioma_id":4,"titulo":"Spectroelectrochemical study of picolinic acid adsorption during silver electrodeposition","resumen":"The adsorption of picolinic acid (PA) onto HOPG electrodes during silver electrodeposition at pH 3.0 was examined using conventional electrochemical techniques: cyclic voltammetry and impedance measure- ments (differential capacity-potential plots) and Surface-Enhanced Raman Spectroscopy (SERS), through a wide range of electrode potentials. The spectroelectrochemical results indicate that the electroactive species for silver electrodeposition are Ag+ ions and [Ag(Pic)] complexes, in spite of the predominant species in solution being the zwitterion (HPic). Adsorption of the anion (Pic?) occurs through a wide potential range where the electrode surface charge density is positive. However, HPic deprotonation, hydrogen formation and Pic? desorption, with the consequent decrease in SERS intensity, occur at the zero-charge potential (pzc) for HOPG.","palabras_clave":"Surface-Enhanced Raman Spectroscopy|silver electrodeposition|picolinic acid |Adsorption"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17525,"idioma_id":4,"titulo":"Kinetics of the hydrogen evolution on nickel in alkaline solution: new insight from rotating disk electrode and impedance spectroscopy analysis","resumen":"Nickel catalysts were characterized for the hydrogen evolution reaction (HER) using rotating disk electrode (RDE) and electrochemical impedance spectroscopy (EIS). The theoretical Levich slope was calculated on the basis of the HER mechanism in alkaline solution. Kinetic and thermodynamic parameters of the reaction were obtained for fresh polished nickel electrode (Nif), and for nickel after a quick chronoamperometric aging procedure (Nipc). Koutecky-Levich analysis indicated that the rate determining step on Nif is the one-electron Volmer reaction, while for Nipc decreases from one to 0.68 and exhibits a strong temperature dependence. A loss of catalytic activity, corresponding to an  increase of 0.3 V of the HER onset potential, was observed after aging. Furthermore, from the EIS-Tafel analysis we concluded that the H adsorption changes from a Langmuir type for Nif, to a Temkin type for Nipc.","palabras_clave":"Hydrogen Evolution|Nickel Rotating Disk Electrode|Electrochemical Impedance |Ageing"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17526,"idioma_id":4,"titulo":"Solid-surface fluorescent properties of estrogens: Green analytical applications","resumen":"For the first time, the fluorescent signals produced by 17&#946;-estradiol (E2), estradiol valerate (E2V) and 17&#945;-ethinylestradiol (EE2) were investigated after being retained in selected solid surfaces. Among different studied supports, both C18 and nylon membranes demonstrated to have been able to induce intense signals over their surface, after aqueous solutions of the analytes were retained via a solid-phase extraction procedure. Physico-chemical variables which affect the quality of the fluorescence signals were optimized, and the results obtained in the studied solid supports were compared and discussed. While nylon successfully faced the trouble of spectrofluorimetrically quantifying estrogens in pharmaceuticals with unbalanced estrogen\/progestagen ratios, C18 membranes showed very good qualities for second-order spectrofluorimeric measurements, allowing the determination of E2 (the most active estrogen) in potentially contaminated fish and chicken samples. The fluorescence excitation?emission matrices, directly measured on a C18 surface, were processed using appropriate chemometric algorithms in order to efficiently quantify E2 in the presence of natural matrix constituents. The present strategy avoids the elution step, considerably decreasing the use of organic solvents, the analysis time and the experimental errors. In addition, the instrumental involved is nonsophisticated and, therefore, the experiments could be carried out in routine laboratories.","palabras_clave":"SOLID-SURFACE SPECTROFLUORIMETRIC|C18 MEMBRANES|NYLON MEMBRANES|SECOND-ORDER CALIBRATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17527,"idioma_id":4,"titulo":"Oxalic acid at the TiO2\/water interface under UV(A) illumination: Surface reaction mechanisms","resumen":"It is through the comparison of experimental results and theoretical calculations that themechanistic details of several surface photoreactions initiated upon UV(A)-illumination of adsorbedoxalic acid on rutile and anatase can be proposed. The absorption of light is found to be ratherlocalized at surface Ti atoms and at the adsorbed species on both TiO2 polymorphs, respectively.Different surface complexes exhibit different photoreactivities and, consequently, each of them mayfollow a different reaction mechanism. Experimental data can be explained involving reactions suchas the interconvertion of monodentate into bidentate species which may further oxidize to CO2 ormay even produce ·OH radicals, while the reduction of monodentate species to the respectivealdehyde results in combination with the oxidation of a neighbouring adsorbed OH group into theformation of an adsorbed ·OOH radical. On the basis of the results presented herein it is concludedthat the direct action of the photocatalytically produced electron\/hole pairs on the adsorbed speciesis the primary step of the photocatalytic reaction, whilst the intermediate formation of free radicalspecies followed by their reaction with an oxalate molecule can be regarded as a secondary process.Within the system described in this work, ·OH radicals only appear to be produced following thedirect interaction of a hole with the adsorbed organic compound but not with chemisorbed watermolecules.","palabras_clave":"ADSORPTION|TITANIUM DIOXIDE|SURFACE REACTIONS MECHANISMS|OXALIC ACID"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17528,"idioma_id":5,"titulo":"Atlas argentino de emisiones de carbono debido  al sector transporte.","resumen":"Se plantea un procedimiento sencillo para preparar un inventario de emisiones grillado de alta resolución (9×9 km) para el sector transporte basado en un sistema de información geográfico usando información de fácil acceso. La variable básica usada es la actividad vehicular (vehículo-km transportado) que se estima a partir del consumo de combustible y una eficiencia de combustible. Esta información luego se distribuye estáticamente a la grilla según unajerarquía vial y la longitud del segmento asignada a cada calle. El consumo de combustible se obtiene del consumo por distrito, y luego se distribuye a nivel urbano usando la banda roja de la imagen satelital DMSP-OLS Earth at night. Esto es necesario ya que no existe información local o urbana de la distribución del consumo de combustible a esa escala. La comparación con bases internacionales mostró una mejor distribución espacial de las emisiones de gasesde efecto invernadero (GEI) del sector transporte, pero similares valores nacionales totales.","palabras_clave":"INVENTARIO DE EMISIONES|TRANSPORTE|SIG|DISTRIBUCIÓN ESPACIAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17529,"idioma_id":4,"titulo":"High resolution inventory of GHG emissions of the road transport sector in Argentina","resumen":"Air quality models require the use of extensive background information, such as land use and topographymaps, meteorological data and emission inventories of pollutant sources. This challenge increases whenconsidering the vehicular sources. The available international databases have uneven resolution for allcountries including some areas with low spatial resolution associated with large districts (severalhundred km). A simple procedure is proposed in order to develop an inventory of emissions with highresolution (9 km) for the transport sector based on a geographic information system using readilyavailable information applied to Argentina. The basic variable used is the vehicle activity (vehicle e kmtransported) estimated from fuel consumption and fuel efficiency. This information is distributed to aspatial grid according to a road hierarchy and segment length assigned to each street within the cell.Information on fuel is obtained from district consumption, but weighted using the DMSP-OLS satellite?Earth at night? image. The uncertainty of vehicle estimation and emission calculations was tested usingsensitivity Montecarlo analysis. The resulting inventory is calibrated using annual average daily trafficcounts in around 850 measuring points all over the country leading to an uncertainty of 20%. Uncertaintiesin the emissions calculation at pixel level can be estimated to be less than 12%. Comparisonwith international databases showed a better spatial distribution of greenhouse gases (GHG) emissionsin the transport sector, but similar total national values.","palabras_clave":"HIGH RESOLUTION EMISSIONS INVENTORY|ROAD TRANSPORT SECTOR|GEOGRAPHIC INFORMATION SYSTEM|SPATIAL DISTRIBUTION|VEHICLE-KILOMETER TRANSPORTED|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17530,"idioma_id":5,"titulo":"Efectos adversos cardíacos de la domperidona en pacientes adultos: revisión sistemática","resumen":"Background: Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported.Aim: To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer. Material and Methods: Systematic searches in MEDLINE, LILACS, SciELO, the Cochrane Library and regulatory agencies websites were performed, followed by a manual search of cited references. The search strategy consisted of combining free and indexed text words without any date or language restriction. Results: Three case-control studies met the inclusion criteria; none of them evaluated QT interval prolongation. With low risk of bias, each study quantified the risk of ventricular arrhythmia or sudden cardiac death (VA\/SCD). The odds ratios for these events in these studies were 4.7 (95% confidence interval (CI): 1.4-16), 1.59 (95% CI: 1.28-1.98) and 11.02 (95% CI: 2.02-62.3) respectively. A significantly increased risk was observed in patients older than 60 years of age or receiving doses > 30 mg\/day. Conclusions: Heterogeneity between selected studies did not allow the computation of a summary measure. However, evidence was found that an increased risk of VA\/SCD is associated with the use of oral domperidone in adults.","palabras_clave":"ARRHYTHMIAS, CARDIAC|DOMPERIDONE|LONG QT|REVIEW"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17532,"idioma_id":5,"titulo":"Calidad editorial y calidad científica en los parámetros para inclusión de revistas científicas en bases de datos en Acceso Abierto y comerciales","resumen":"      Se analizan los parámetros de  evaluación utilizados por RedALyC, Catálogo Latindex, SciELO, Scopus y Web of  Science para incorporar revistas científicas en sus colecciones a fin de demostrar su  relación con los objetivos perseguidos por cada base y debatir acerca de la  valoración que la comunidad científica está otorgándole a estos sistemas como  determinantes de ?calidad científica?. Los indicadores utilizados se  clasifican en: 1) Calidad&nbsp; editorial  (aspectos formales ó gestión editorial); 2) Calidad de contenido (revisión por  pares ó originalidad) y 3) Visibilidad (prestigio de editores y editorial, endogamia,  uso e impacto, accesibilidad ó indización). Se revela que: a) entre  un 9 y un 16% se relacionan con la calidad de contenido; b) falta especificidad en  sus definiciones y en la determinación de sus pesos específicos en los  sistemas, y c) coinciden con los objetivos de cada base, aunque se observa una  marcada tendencia hacia los relacionados con aspectos formales y visibilidad.  Se deja así en evidencia que estos sistemas persiguen sus propios objetivos y  que conforman núcleo de revistas de ?calidad? para su público lector. Se  concluye, en consecuencia, que la presencia o ausencia de una revista en estas  colecciones, no es parámetro suficiente para determinar la calidad de las  revistas científicas ni de sus contenidos.  ","palabras_clave":"EVALUACIÓN CIENTÍFICA|REVISTAS CIENTÍFICAS|CALIDAD EDITORIAL|SISTEMAS DE EVALUACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17533,"idioma_id":4,"titulo":"On the use of High-Order Cumulant and Bispectrum for  Muscular-Activity Detection","resumen":"The electromyographic (EMG) signals are extensively used on feature extraction methods for movement classification purposes. High-Order Statistics (HOS) is being employed increasingly in myoelectric research. HOS techniques could be represented in the frequency domain (high-order spectra, e.g., bispectrum, trispectrum) or in the time domain (higher-order cumulants). More calculus is required for computing the HOS in the frequency domain. On the one hand, classical bispectrum-based features were applied to EMG signals. We propose novel third-order cumulant-based features for EMG signals. Three different classifiers are implemented for muscular-activity detection. Different analysis and evaluations were applied to both HOS-based features in order to qualify and quantify similarities. Based on these results, it is possible to conclude that cumulant-based features and bispectrum-based features had comparable behavior and allowed similar classification rates. Hence, extra calculus in order to convert time- to frequency-domain should be avoided.","palabras_clave":"EMG| HOS|Cumulants|Bispectrum"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17534,"idioma_id":5,"titulo":"Análisis de un conjunto material del primer milenio d.c. del sitio Antumpa (Dpto. Humahuaca, Jujuy). El caso del sector 'Terraza'","resumen":"En este trabajo se presenta información acerca del componente Temprano o Formativo (ca. 1000 a.C.-1000 d.C.) del sitio arqueológico Antumpa (Departamento Humahuaca, Jujuy). Este sitio es uno de los pocos conocidos para este rango temporal en la zona y, por ende, la información aquí aportada contribuye a profundizar el conocimiento disponible de las sociedades aldeanas que habitaron la región durante este momento. En particular, se describen las investigaciones desarrolladas en un sector del sitio que presentaba material arqueológico en superficie aunque sin una asociación clara con estructuras bien definidas, denominado sector Terraza, por su ubicación en una superficie aterrazada intencionalmente dentro de un canchón de cultivo. La investigación en este sector produjo evidencias arqueológicas variadas, incluyendo un fechado radiocarbónico, que son significativas tanto para avanzar en la caracterización y comprensión de la historia de ocupación de Antumpa como para contribuir a profundizar los conocimientos disponibles acerca de un momento crucial y poco conocido en la secuencia prehispánica de la Quebrada de Humahuaca.","palabras_clave":"Antumpa|Quebrada de Humahuaca|sector Terraza|Formativo o Temprano"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17535,"idioma_id":5,"titulo":"El conocimiento y la comunicación de la dimensión natural dentro de una perspectiva de la especialidad contable socio-ambiental","resumen":"ResumenSe considera importante la emisión de informes contables socio-ambientales para la sustentabilidad y se intenta contribuir a la comprensión de un lineamiento para obtener conocimientos a través de la denominada especialidad contable socio-ambiental. Se seleccionan  desarrollos, se realizan análisis críticos y comparaciones, se obtienen resultados y se infieren conclusiones. Se infiere, entre otras, que la especialidad contable socio-ambiental permite obtener y brindar conocimientos de parte de la realidad ambiental de las organizaciones económicas, los que pueden constituir tanto una entrada fundamental del proceso de innovación como una salida importante de los resultados innovados.","palabras_clave":"CIENCIA CONTABLE|CONTABILIDAD SOCIO-AMBIENTAL|INFORMACION SOCIO-AMBIENTAL|DIMENSION NATURAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17536,"idioma_id":4,"titulo":"Genetic patterns of Streptococcus uberis isolated from bovine mastitis","resumen":"    The aim of this study was to evaluate genotypic relationships among 40 Streptococcus  uberis isolated bovine mastitis by using pulse field gel electrophoresis.  Additionally, association between PFGE patterns and virulence profiles was  investigated. The isolates exhibited 17 PFGE patterns. Different strains were  found within and among herds, but a low number of isolates within the same herd  shared an identical PFGE type. Any association between PFGE patterns and  virulence profiles was not found. However, evidence of particular strains in  some herds could indicate that some strains are more virulent than others.  Further research needs to be undertaken to elucidate new genes related to  virulence that might contribute to capability of infecting of these strains.  ","palabras_clave":"STREPTOCOCCUS UBERIS |PULSE FIELD GEL ELECTROPHORESIS |VIRULENCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17537,"idioma_id":4,"titulo":"A complete vibrational study on a potential environmental toxicant agent, the 3,3',4,4'-tetrachloroazobenzene combining the FTIR, FT Raman, UV?Visible and NMR spectroscopies with DFT calculations","resumen":"A complete vibrational study on a potential environmental toxicant agent, the 3,3?,4,4?-tetrachloroazobenzene combining the FTIR, FTRaman, UV-Visible and NMR Spectroscopies with DFT calculations.","palabras_clave":"Espectroscopia vibracional"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17538,"idioma_id":4,"titulo":"FT-IR, FT-Raman, UV-Visible, and NMR spectroscopy and vibrational properties of the labdane-type diterpene 13-epi-sclareol","resumen":"FT-IR, FT-Raman, UV-Visible, and NMR spectroscopy and vibrational properties of the labdane-type diterpene 13-epi-sclareol","palabras_clave":"Espectroscopia vibracional"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17539,"idioma_id":4,"titulo":"Spectroscopic and structural studies on lactose species in aqueous solution combining the HATR and Raman spectra with SCRF calculations","resumen":"In this work, the a and b isomers, the a-lactose monohydrate and dihydrate and the dimeric species of  lactose were studied from the spectroscopic point of view in gas and aqueous solution phases combining  the infrared, Horizontal Attenuated Total Reflectance (HATR) and Raman spectra with the density  functional theory (DFT) calculations. Aqueous saturated solutions of a-lactose monohydrate and solutions  at different molar concentrations of a-lactose monohydrate in water were completely characterized  by infrared, HATR and Raman spectroscopies. For all the species in solution, the solvent effects were  studied using the solvation polarizable continuum (PCM) and solvation (SM) models and, then, their  corresponding solvation energies were predicted. The vibrational spectra of those species in aqueous  solution were completely assigned by employing the Scaled Quantum Mechanics Force Field (SQMFF)  methodology and the self-consistent reaction field (SCRF) calculations. The stabilities of all those species  were studied by using the natural bond orbital (NBO), and atoms in molecules (AIM) calculations.","palabras_clave":"Lactose   |Vibrational spectra| Molecular structure|Force field|DFT calculations"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17540,"idioma_id":5,"titulo":"AVANCES EN LA RECUPERACIÓN DE ORO Y PLATA MEDIANTE FLOTACIÓN EN ESCORIAS DE FUNDICIÓN","resumen":"El objetivo del presente trabajo es recuperar y mejorar la obtención de oro y plata, presentes en escorias de fundición, mediante diferentes procesos metalúrgicos aplicables en menas. La escoria se concentró en una centrífuga tipo Knelson, obteniendo dos concentrados (C1 y C2) y una cola (T1). Para mejorar la recuperación, se realizó la flotación en tres etapas sobre la cola T1. Las variables utilizadas fueron: tamaño de partícula, uso de colectores de xantantos de cadena corta, ditiofosfato y tiempos variables de flotación. Se concluye que la recuperación de Au y Ag, aplicando concentración por gravedad (centrífuga Knelson) son del 42% y 13.7 % respectivamente. La recuperación de Au se mejora en un 87.7% a través de la flotación de la cola de la separación centrífuga y en un 47.4 %  para la Ag. Siendo las condiciones óptimas: granulometría a 200#, colectores: Pax (15.8 g\/t); F-C5439 (18.75 g\/t), espumante MIBC (12.5 g\/t) y un tiempo de flotación de 8.5 minutos.","palabras_clave":"CONCENTRACION GRAVIMETRICA|MINERAL|MENA|ESCORIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17541,"idioma_id":4,"titulo":"A taxonomically unique Acinetobacter strain with proteolytic and hemolytic activities recovered from a patient with a soft tissue injury","resumen":"A taxonomically unique bacterial strain, Acinetobacter sp. A47, has been recovered from several soft tissue samples from a patient undergoing reconstructive surgery owing to a traumatic amputation. The results of 16S rRNA, rpoB, and gyrB gene comparative sequence analyses showed that A47 does not belong to any of the hitherto-known taxa and may represent an as-yet-unknown Acinetobacter species. The recognition of this novel organism contributes to our knowledge of the taxonomic complexity underlying infections caused by Acinetobacter.","palabras_clave":"ACINETOBACTER|TAXONOMY|SOFT TISSUE INFECTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17542,"idioma_id":5,"titulo":"Investigación en Progreso: Ingeniería de Software en el Desarrollo de Aplicaciones  Sensibles al Contexto","resumen":"Las aplicaciones han ido evolucionandoindependientemente de cuál sea su dominio de aplicación,actualmente nos encontramos con aplicaciones que puedenbrindar servicios de acuerdo a la ubicación, tiempo y perfil delusuario. Este tipo de aplicaciones que brindan estos servicios selas conoce como Aplicaciones Sensibles al Contexto (CA ?Context Aware), en este tipo de aplicaciones predominan losdispositivos móviles y el perfil del usuario. La evolución varía enfunción de la forma de uso de la computadora, es decir que sebrinden servicios a pedido del usuario o que se brinden serviciosde manera automática.Para acompañar la evolución de este tipo de aplicaciones, laIngeniería de Software ha focalizado sus esfuerzos en aspectosrelacionados a separar la aplicación de todo lo concerniente a lacaptación, interpretación, control y supervisión de la informacióncontextual.Es decir que desde el punto de vista del diseño, se separe laconducta sensible al contexto de la conducta propia de laaplicación con el propósito de que ambos tipos de aplicacionespueden evolucionar en forma independiente además de reducir eltiempo de desarrollo en este tipo de sistemas.Este proyecto presenta una sub línea, la cual orientará susaportes, en la consolidación de un framework de gestióncontextual de dos o tres variables de contexto como por ejemplo:la ubicación, considerando la construcción de la documentaciónrelevante que lo respalde como así también su fase deexperimentación con una aplicación que permitirá a los usuariosde la comunidad universitaria UM hacer uso de los serviciosofrecidos por la misma.La segunda sub línea, se vincula al Área de la Ingeniería deRequisitos, pretendiendo obtener un modelo para laespecificación de requisitos de software para sistemas sensibles alcontexto. ","palabras_clave":"INGENIERIA DE SOFTWARE|APLICACIONES SENSIBLES AL CONTEXTO|FRAMEWORK|SISTEMAS PERVASIVOS COMPUTACION UBICUA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17543,"idioma_id":4,"titulo":"Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei","resumen":"The suprachiasmatic nuclei, the main circadian clock in mammals, are entrained by light through glutamate released from retinal cells. Astrocytes are key players in glutamate metabolism but their role in the entrainment process is unknown. We studied the time dependence of glutamate uptake and glutamine synthetase (GS) activity finding diurnal oscillations in glutamate uptake (high levels during the light phase) and daily and circadian fluctuations in GS activity (higher during the light phase and the subjective day). These results show that glutamate-related astroglial processes exhibit diurnal and circadian variations, which could affect photic entrainment of the circadian system.","palabras_clave":"SCN|astrocytes|glutamate|circadian"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17544,"idioma_id":4,"titulo":"Wheat spike fertility: inheritance and relationship with spike yield components in early generations","resumen":"In wheat, grain number is considered as the product of spike dry weight (SDW) and the number of grains per unit of SDW, that is an indicator of spike fertility (SF). The aim of this study was to determine the heritability of SF and the effect of early selection for high SF on its relationship with other spike yield components. Two field experiments were conducted in the south-eastern Pampas (Argentina) with 400 F2 and F2:3 families obtained from two crosses between varieties with contrasting SF (PIG\/SSN and B10\/KCJ). Heritability estimates in PIG\/SSN and B10\/KCJ were, respectively, 0.60 and 0.51 by variance component analysis, 0.43 and 0.43 by F2 : F3 parent?offspring regression and 0.30 and 0.28 by realized heritability analysis. The existence of transgressive segregation (i.e. the occurrence of families with SF values that were more extreme than those of the parents) was observed. The top 25% F3 families with the highest SF had 12% more grains per spike, despite a 13% and 5% decrease in SDW per spike and weight per grain, respectively, than the remaining families. These results give support to the application of early selection for high SF.","palabras_clave":"GRAIN NUMBER|CHAFF DRY WEIGHT|GRAIN WEIGHT|SELECTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17545,"idioma_id":4,"titulo":"Composite ceramic membranes from natural aluminosilicates for microfiltration applications","resumen":"    This work concerns  to the development and characterisation of support, active layer and tubular  composite membranes (CM) from natural aluminosilicates as principal components  (clay, bentonite, feldspar, quartz, alumina). The selection of these raw  materials was primarily based on their low cost and they are locally produced.  In the substrates preparation, the effect of materials compositions, additives,  particle sizes, paste rheological properties, and drying-sintering temperatures  was investigated. The consolidated ceramic substrates were characterised by  SEM, DTA-TG, X-Ray diffraction, Hg intrusion, mechanical resistance, and water  flux measurements. Extrusion has been used as the forming process of tubular  support. The CM was fabricated depositing a thin active layer by slip-casting  method on the support. The CM sintered at 1200ºC showed the best structural  characteristics, porosities of 50%, active layer pore size between 0.08-0.55  &#956;m. The CM hydraulic permeabilities (10-274 L\/hm2kPa) were  comparable and greater than several inorganic commercial membranes and CM  obtained from other researches. The CM microfiltration effectiveness was tested  with different substances from food industry, i.e. slaughterhouse wastewater  treatment and goat milk pasteurization. The obtained results, insoluble residue  rejections (100%), and high bacterial removal (87-99%) make the ceramic CM  suitable for microfiltration processes.  ","palabras_clave":"Sintering|Aluminosilicates|Ceramic membranes|Compositematerials"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17546,"idioma_id":4,"titulo":"DEVELOPMENT OF HIGH SILICON DUAL PHASE ADI","resumen":"This work deals with the feasibility of obtaining Austempered Ductile Iron with Dual Phase structures (DPADI) through heat treatment, starting from different as-cast microstructures. The mechanical properties on these microstructures were evaluated. DPADI microstructures were obtained by adding different tenors of silicon (2.4% to 4.2%) to the melts and keeping the other alloying elements constant. The study focused on the determination of the time required to achieve the percentages of equilibrium phases (ferrite and austenite) at different temperatures in the intercritical temperature interval as a function of the starting as cast microstructure. The results showed that, as the silicon content increases, higher amount of ferrite is present in the as cast structure, and the time required to reach the thermodynamic equilibrium phases in the intercritical temperature interval is markedly reduced. Similarly, for a constant chemical composition, as the intercritical austenitizing temperature increases, the time required to reach the quantities of the equilibrium phases decreases. Regarding mechanical properties, the tests revealed that, as expected, as intercritical austenitising temperature increases so do tensile strength and hardness due to the higher ausferrite content in the DPADI matrix. These results indicate that high silicon Ductile Iron (with Si content higher than 3%) with a mostly ferritic microstructure in as cast conditions yields DPADI microstructures able to dispense with prior annealing heat treatments since the time required to reach the phase equilibrium percentages is compatible with the industrial practice and the mechanical properties are similar as compared to DPADI structures deriving from fully ferritic matrices.","palabras_clave":"Ductile Iron|Microestructure|Dual Phase|Silicon|Intercritical Interval"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17547,"idioma_id":4,"titulo":". Possible predation by the striped weakfish Cynoscion guatucupa on estuary-associated fishes in an Argentinian coastal lagoon","resumen":"Cynoscion guatucupa is one of the most important coastal fishery resources of Argentina and Uruguay with both juveniles and adults being recorded in Mar Chiquita coastal lagoon, a shallow water estuarine lagoon in Argentina. Cynoscion guatucupa enters and exits the lagoon following tidal cycles, with residence time within the lagoon lasting only for the duration of a tidal cycle. The main objective of this study was to determine the diet composition of Cynoscion guatucupa captured in the lagoon, and to determine if different size classes of this species differentially utilize available food resources during their residency within the coastal lagoon. The diet of 511 specimens of C. guatucupa was analyzed. The most important prey item in %IRI was Peisos petrunkevitchi, followed by juvenile teleosts including those of Micropogonias furnieri, Odontesthes argentinensis and Mugil platanus. Cynoscion guatucupa enters the lagoon to feed on a variety of invertebrates as well as juvenile teleost fishes. Diet composition showed ontogenetic changes: smaller individuals predominantly consume crustaceans, and as size increases they begin to prey more on teleosts, with the largest fishes specializing on fish. The present study reinforces the role of estuaries for marine fishes as both feeding grounds, for juveniles and adults and as refuge areas for juveniles. Furthermore, this study also highlights the importance of food habit studies, for understanding the trophic ecology of fishes and estuarine food web dynamics.","palabras_clave":"Diet composition|ontogenetic changes|juvenile fish consumption|resource use"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17548,"idioma_id":4,"titulo":"Erythropoietin as a new therapeutic opportunity in brain inflammation and neurodegenerative diseases","resumen":"Highly expressed Erythropoietin Receptor (EPO-R) has been detected in   several nonhematopoietic hypoxic cells, including cells from different   brain areas in response to many different types of cell injury. In   brain, hypoxia-ischemia (HI) can induce a wide spectrum of biologic   responses, where inflammation and apoptosis are the main protagonists.   Inflammation, as a primary brain insult, can induce a chronic hypoxic   condition, producing the continuous cycle of inflammation-hypoxia that   increases the apoptotic-cell number. It has also been demonstrated that   administration of erythropoietin (EPO) prevented the neuronal death   induced by HI, as well as the induction of lipid peroxidation in the   hippocampus in a rodent model of Alzheimer´s disease. Anti-apoptotic,   anti-inflammatory, anti-oxidant, and\/or cell-proliferative effects of   EPO, have been observed in all type of cells expressing EPO-R, resulting   in a potential tool for neuroprotection, neuroreparation, or   neurogenesis of brain damaged areas. The nasal route is an alternative   way of drugs administration that has been successfully exploited for   bypassing the blood brain barrier, and subsequently delivering EPO and   other molecules to central nervous system. Intranasal administration of   EPO could be a new therapeutic opportunity in several brain damages that   includes hypoxia, inflammation, neurodegenerative process, and   apoptosis.","palabras_clave":"Erythropoietin| brain inflammation| epilepsy| neurodegenerative diseases"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17549,"idioma_id":4,"titulo":"Recruitment of juvenile fishes into a small temperate choked lagoon (Argentina) and the influence of environmental factors during the process","resumen":"Juvenile fishes were sampled every 15 days from September 2009 to April 2010 along the marine-estuarine gradient (i.e. Surf zone, Estuary, a freshwater stream) of the Mar Chiquita lagoon (Argentina). The temporal variations of juvenile assemblages during spring-summer and the environmental variables related to the spatial and temporal patterns were analyzed. Four groups of sampling stations were defined indicating differences in fish composition among zones during the Spring-Early Summer period (Groups I to III) while the composition of juvenile fishes was homogeneous along the marine-estuarine gradient during the Late summer-Early autumn period (Group IV). Platanichthys platana and Ramnogaster arcuata (Group A) and Odontesthes argentinensis and Brevoortia aurea (Group B) contributed most to the temporal differences observed. The three first species reached this estuarine system during Spring, although with lower abundances in relation to Early Summer, while B. aurea was dominant during Late Summer-Early Autumn showing distinct recruitment periods to the lagoon by these species. After factoring out shared spatial-temporal-environmental factors variation (4.43%), the canonical correspondence analysis (CCA) showed that temporal components had an almost 5-fold greater contribution (15.15%) than spatial components (2.85%) and almost twice than the pure environmental factors (8.11%) in explaining the variation in abundance of the juvenile fishes. From the significant environmental variables incorporated in the CCA, wind direction contributed most than water temperature, salinity or transparency in explaining data variability. Indeed, most species were related to ?onshore winds? and therefore, the importance of wind on the successful recruitment of juveniles into this shallow and micro-tidal estuary is discussed.","palabras_clave":"Nursery grounds|fish|juvenile|brackish water environment|surf zone|environmental factors|winds|Mar Chiquita coastal lagoon"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17550,"idioma_id":4,"titulo":"Relaxation of isolated quantum systems beyond chaos","resumen":"In classical statistical mechanics there is a clear correlation between relaxation to equilibrium and chaos. In contrast, for isolated quantum systems this relation is?to say the least?fuzzy. In this work we try to unveil the intricate relation between the relaxation process and the transition from integrability to chaos. We study the approach to equilibrium in two different many-body quantum systems that can be parametrically tuned from regular to chaotic. We show that a universal relation between relaxation and delocalization of the initial state in the perturbed basis can be established regardless of the chaotic nature of system.","palabras_clave":"QUANTUM THERMODINAMICS|QUANTUM CHAOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17551,"idioma_id":4,"titulo":"Hemodialysis decreases carotid-brachial and carotid-femoral pulse wave velocities: A 5-year follow-up study","resumen":"Aortic stiffness is a prognostic parameter associated with patient mortality. Vascular access creation has been shown to have effects on arterial stiffness both in the aorta and in the upper limb arteries in chronically hemodialyzed patients (CHPs). However, no longitudinal studies have been conducted in order to characterize the evolution of arterial stiffness in CHPs. The aims of this work were (a) to measure baseline pulse wave velocity (PWV) in the carotid-femoral and in right and left carotid-brachial pathways in a cohort of CHP and (b) to conduct a 5-year prospective study on the same cohort to determine possible time-related differences. Pulse wave velocity was measured both in the carotid-femoral and in the carotid-brachial pathways, and clinical and biochemical parameters were collected in 25 CHPs, which were followed up after a 5-year lapse. Right and left carotid-brachial pathway PWV values showed significant decreases after the 5-year follow-up, independently of the presence of the vascular access (P&#8201;<&#8201;0.001). Additionally, baseline carotid-brachial PWV was significantly higher (P&#8201;<&#8201;0.001) than values measured 5 years later for upper limbs with vascular access (11.97&#8201;±&#8201;2.97&#8201;m\/sec vs. 6.76&#8201;±&#8201;1.48&#8201;m\/sec, respectively) and without vascular access (12.25&#8201;±&#8201;2.38&#8201;m\/sec vs. 7.18&#8201;±&#8201;1.88&#8201;m\/sec, respectively). Similarly, PWV values in the carotid-femoral pathway decreased significantly (P&#8201;<&#8201;0.001) over the same period (13.27&#8201;±&#8201;2.96&#8201;m\/sec vs. 9.75&#8201;±&#8201;2.99&#8201;m\/sec, respectively). The 5-year follow-up of PWV showed significant decreases in both carotid-brachial and carotid-femoral pathways. The general changes in arterial stiffness could be related to the vascular access creation, hemodialysis therapy, and to the improvement of arterial pressure management.","palabras_clave":"pulse wave velocity|vascular access|stiffness|hemodialysis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17552,"idioma_id":4,"titulo":"Cationization of kappa- and iota-carrageenan - Characterization and properties of amphoteric polysaccharides","resumen":"Commercial kappa- and iota carrageenans were cationized with 3-chloro-2-hydroxypropyltrimethylammonium chloride in aqueous sodium hydroxide solution. For kappa-carrageenan three derivatives with different degrees of substitution were obtained. Native and amphoteric kappa-carrageenans were characterized by NMR and infrared spectroscopy, scanning electron and atomic force microscopy; methanolysis products were studied by electrospray ionization mass spectrometry. Young moduli and the strain at break of films, differential scanning calorimetry, rheological and flocculation behavior were also evaluated; the native and the amphoteric derivatives showed different and interesting properties. Cationization of iota-carrageenan was more difficult, indicating as it was previously observed for agarose, that substitution starts preferentially on the 2-position of 3,6-anhydrogalactose residues; in iota-carrageenan this latter unit is sulfated.","palabras_clave":"KAPPA-CARRAGEENAN|IOTA-CARRAGEENAN|CATIONIZATION|AMPHOTERIC POLYSACCHARIDES|3-CHLORO-2-HYDROXYPROPYLTRIMETHYLAMMONIUM CHLORIDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17553,"idioma_id":4,"titulo":"A critical review on heat transfer in trickle bed reactors","resumen":"A critical review of the available information  about heat transfer between a packed bed with cocurrent  downflow of gas and liquid and an external medium was  undertaken. Several aspects such as experimental set-ups  and methods employed to study heat transfer in trickle  bed reactors, models used to interpret experimental data,  and literature correlations of heat transfer parameters are  addressed. From the analysis of the available experimental  information, a refined database has been built, which  allows comparing the performance of the existing correlations  for the parameters of the extensively employed twodimensional  pseudohomogeneous plug flow model (i.e.,  effective radial thermal conductivity and wall heat transfer  coefficient). In addition, new correlations for effective  thermal conductivity have been developed. Identification  of gaps in the current knowledge and recommendations  for future works are summarized.","palabras_clave":"heat transfer mechanisms|heat transfer models|radial thermal conductivity|wall heat transfer coefficient"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17554,"idioma_id":5,"titulo":"Sobre el uso de heurísticas como posible solución del problema de marco","resumen":"Se ha propuesto (y criticado) el uso de heurísticas como una herramienta para solucionar el problema de marco. Los objetivos de este trabajo son proveer una clarificación de la literatura filosófica sobre el tema e intentar resolver los debates pendientes considerando la evidencia empírica disponible. Luego de distinguir varios aspectos del problema de marco, analizaremos las disputas filosóficas sobre el tema. A continuación, comentaremos la literatura sobre la evidencia empírica relevante proveniente de la psicología cognitiva. Argumentaremos que las heurísticas pueden ser útiles para solucionar sólo un aspecto del problema de marco y ello aún con varias restricciones.","palabras_clave":"Heurísticas|Problema de marco|Evidencia empírica |Psicología Cognitiva"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17555,"idioma_id":4,"titulo":"Neurotransmitter GABA Activates Muscle but not a7 Nicotinic Receptors","resumen":"Cys-loop receptors are neurotransmitter-activated ion channels involved   in synaptic and extrasynaptic transmission in the brain and are also   present in non-neuronal cells. As GABAA and nicotinic receptors (nAChR)   belong to this family, we explored by macroscopic and single-channel   recordings if the inhibitory neurotransmitter GABA has the ability to   activate excitatory nAChRs. GABA differentially activates nAChR   subtypes. It activates muscle nAChRs, with maximal peak currents of   about 10 % of those elicited by ACh and 15-fold higher EC50 with respect   to ACh. At the single-channel level, the weak agonism is revealed by   the requirement of 20-fold higher concentration of GABA for detectable   channel openings, a major population of brief openings, and absence of   clusters of openings when compared to ACh. Mutations at key residues of   the principal binding-site face of muscle nAChRs (&#945;Y190 and &#945;G153)   affect GABA-activation similarly as ACh-activation whereas a mutation at   the complementary face (&#1013;G57) shows a selective effect for GABA.   Studies with subunit-lacking receptors show that GABA can activate   muscle nAChRs through the &#945;\/&#948; interface. Interestingly, single-channel   activity elicited by GABA is similar to that elicited by ACh in   gain-of-function nAChR mutants associated to congenital myasthenic   syndromes, which could be important in the progression of the disorders   due to steady exposure to serum GABA. In contrast, GABA cannot elicit   single-channel or macroscopic currents of &#945;7 or the chimeric &#945;7-5HT3A   receptor, a feature important for preserving an adequate   excitatory\/inhibitory balance in the brain as well as for avoiding   activation of non-neuronal receptors by serum GABA","palabras_clave":"GABA |alpha 7 receptors|muscle nicotinic receptor"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17556,"idioma_id":4,"titulo":"A new series of antibacterial nitrosopyrimidines. Synthesis and  structure-activity relationship.","resumen":"New nitrosopyrimidines were synthesized and evaluated as potential antibacterial agents. Different compounds structurally related with 4,6-bis(alkyl or arylamino)-5-nitrosopyrimidines were evaluated. Some of these nitrosopyrimidines displayed significant antibacterial activity against human pathogenic bacteria. Among them compounds 1c, 2a-c, and 9a-c exhibited remarkable activity against methicillin-sensitive and -resistant Staphylococcus aureus, Escherichia coli, Yersinia enterocolitica, and Salmonella enteritidis. A detailed structure-activity relationship study, supported by theoretical calculations, aided us to identify and understand the minimal structural requirements for the antibacterial action of the nitrosopyrimidines reported here. Thus, our results have led us to identify a topographical template that provides a guide for the design of new nitrosopyrimidines with antibacterial effects.","palabras_clave":"nitrosopirimidinas|SAR|antibacterials"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17557,"idioma_id":4,"titulo":"First report of Alternaria alternata causing black spot on pink lapacho (Handroanthus impetiginosus)","resumen":"A severe leaf spot disease was observed on pink lapacho trees, Handroanthus impetiginosus for the first time in Buenos Aires province, Argentina during the autumn of 2013. The pathogen was identified as Alternaria alternata based on the morphological characteristics and sequence data from the internal transcribed spacer region of ribosomal DNA, and partial &#946;-tubulin sequence. A pathogenicity test was performed and Koch?s postulates were confirmed by re-isolating the fungus from artificially inoculated leaves. This is the first report of Alternaria black spot of Handroanthus impetiginosus trees.","palabras_clave":"Lapacho|Alternaria alternata|ITS bar code|Leaf spot"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17559,"idioma_id":4,"titulo":"?MÖSSBAUER CELL FOR LOW-TEMPERATURE STUDIES OF CATALYSTS UNDER REACTION CONDITIONS?","resumen":"Mössbauer spectroscopy is an essential tool to investigate the structure of Fe supported catalysts and their changes, when they are used in the Fischer-Tropsch synthesis. A cell, that allows keeping the samples in the same atmosphere of the reduction treatment, was designed in order to characterize the Fe species without changing the working atmosphere avoiding the oxidation. It allows to measure at low temperatures in a helium closed-cycle refrigerator. Besides, this cell is useful to perform Mössbauer measurements on the used catalysts, preserving the oxidation of its species, using an inert atmosphere. In this work, we describe the details of this new cell and, as an example of its utility, we present the results obtained with a system of 12 nm iron oxide nanoparticles supported on a mesoporous silica matrix.","palabras_clave":"MÖSSBAUER SPECTROSCOPY|LOW TEMPERATURES|REACTION CONDITIONS|CATALYSTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17560,"idioma_id":4,"titulo":"Transglutaminase binding fusion protein linked to SLPI reduced corneal inflammation and neovascularization","resumen":"BACKGROUND  To study the effect of topical administration of a fusion protein (PF-MC) made up of Nterminal  portion of the protease inhibitor Trappin-2 (which is a substrate of transglutaminasa-  2) and SLPI (protein with anti-inflammatory, anti-bacterial and anti-viral ability), in an  animal model of corneal inflammation and angiogenesis.    METHODS  An alkali injury was produced with a filter paper of 3 mm with 1 N NaOH during 40 seconds  on the right cornea of 36 male Sprague Dawley rats, under general anesthesia. Animals were  divided into three groups according to treatment. Group 1 was treated with 10 ul of PF-MC  (200 ug\/ml; n = 12), Group 2, with 10 ul of SLPI (200 ug\/ml; n = 12) and Group 3 was  treated with buffer (10ul; n = 12) topically administered four times a day for up to 7 days.  Half of the animals were sacrificed at day 3 before making a re-epithelialization time analysis  with fluorescein staining at 18 and 24 hours. In the remaining animals corneal opacity was  studied and digital photographs were taken at day 7 before doing euthanasia. Eyes were  processed for histology and immunofluorescence.    RESULTS  Corneal ulcerated area was significantly lower in PF-MC treated animals compared to SLPI  and buffer-treated animals at 18 hours and 24 hours postinjury. A clear cornea and fundus red  reflex was only found among PF-MC treated animals. Histological analysis revealed a  stratified corneal epithelium with at least three layers in all PF-MC animals at day 7. In this  group there was a reduced number of PMNs in the corneal stroma at 3 and 7 days of followup.  Besides, corneal neovascularization was much more extended in SLPI and Buffer animals  than in animals treated with PF-MC.    CONCLUSIONS  The binding of SLPI with Cementoin to transglutaminase seems to be an effective strategy to  treat corneal inflammation and angiogenesis.","palabras_clave":"SLPI|CEMENTOIN|TRANSGLUTAMINASE|CORNEAL NEOVASCULARIZATION|ANGIOGENESIS|NF-KB|CORNEAL INFLAMMATION|ALCALI INJURY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17561,"idioma_id":5,"titulo":"Los jóvenes y la escuela secundaria: la escolaridad entre la flexibilidad, la negociación y las transformaciones","resumen":"Este trabajo se enmarca en las actividades de investigación desarrolladasdesde el Área Sociopedagógica de la UNPA-UACO1 y tiene como propósitoaportar a la descripción de las características que asume la escolaridad de losjóvenes en nuestros días atendiendo a un contexto que, en diversos aspectos,está signado por el cambio permanente y la flexibilidad. Nos acercaremosa esta problemática desde la mirada que tienen los docentes sobre losjóvenes y desde sus modos de transitar la escuela secundaria. Partimos de lossupuestos de que la escuela en el presente se encuentra inscripta en escenariossignados por la inmediatez y la flexibilidad (Sennett, 2009), en un mundocada vez más volátil y líquido (Bauman, 2001) y atravesado por transformacionesvinculadas a la globalización de las comunicaciones, a la interconexióntecnológica, a nuevos modos de producción y acceso a la cultura, a políticasde reforma social y educativa. Es decir, a nuevos modos en que los sujetos serelacionan consigo mismos y con los otros (Grinberg, 2008). Aquí nos interesaanalizar la trama de la negociación de distintos aspectos entre la institución,los jóvenes y sus familias porque se conforma como un signo característicode la cotidianeidad de una escuela secundaria que se ha transformado conrespecto a sus objetivos iniciales. Ha pasado de ser selectiva y elitista, sesgoque adquirió en sus inicios, a obligatoria, inclusiva y que promete el reconocimientode la juventud diversa, como parte de las políticas educativas de losúltimos tiempos.","palabras_clave":"ESCUELAS|ESTUDIANTES|FLEXIBILIDAD|GERENCIAMIENTO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17562,"idioma_id":4,"titulo":"In vitro antioxidant potentials and chemistry of essential oils and oleoresins from fresh and sun-dried Mentha longifolia L.","resumen":"The present study was designed to assess differences in chemical composition and antioxidant potential of essential oils and oleoresins from fresh and sun-dried Mentha longifolia L. Essential oils and oleoresins were obtained by hydrodistillation and solvent extraction (n-hexane and ethanol), respectively. The chemical profile was evaluated by using gas chromatography (GC) and GC coupled to mass spectrometry (GC-MS). Antioxidant effectiveness was examined by five different methods, namely the ferric thiocyanate (FTC) method, the 2,2?-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method, determination of the metal chelating power, and determination of the peroxide and Thiobarbituric acid values in mustard oil at 0.02% concentration. The chemical composition was dominated by the presence of piperitenone oxide, an oxygenated monoterpene whose composition varied from 23.2% to 88.5% in both essential oils and oleoresins. Based on the antioxidant potential of essential oils, oleoresins and synthetic antioxidants can be sorted in the following descending order: butylatedhydroxytoluene dried mint essential oil fresh mint essential oil propyl gallate fresh mint ethanol oleoresin dried mint ethanol oleoresin dried mint hexane oleoresin fresh mint hexane oleoresin. The drying process has a significant influence on the qualitative and quantitative content of the extracted substances.","palabras_clave":"ANTIOXIDANT ACTIVITY|ESSENTIAL OIL|OLEORESIN|MENTHA LONGIFOLIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17563,"idioma_id":4,"titulo":"Magnetic composites of CoFe2O4 nanoparticles in a poly(aniline) matrix: Enhancement of remanence ratio and coercivity","resumen":"Magnetic composites of cobalt ferrite nanoparticles and poly(aniline) have been synthesized in acid  media and characterized by X-ray diffraction studies, scanning and transmission electron microscopy  observation, thermogravimetric analysis, conductivity and infrared spectroscopy measurements. The  magnetic behavior was studied through DC magnetization measurements; hysteresis loops were  observed, showing ferromagnetic behavior for particles and composites. The remanence ratio increases  as the polymer contents increases, the coercivity decreases  first and then increases, and the saturation  magnetization does not follow the ferrite mass fraction in the composite. It is proposed that an indirect  exchange mechanism (RKKY-like) between the nanoparticles and PANI localized spins mediated by the  conduction electrons is responsible for the observed magnetic behavior. The results suggest the presence  of particle-matrix interactions related to the amount of polymer present, thus, in turn suggesting that  the material magnetic properties could be controlled through the nanoparticles to polymer ratio.","palabras_clave":"NANOSTRUCTURES|OXIDES|MAGNETIC PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17564,"idioma_id":5,"titulo":"On the Characterization of NaDEHP\/n-Heptane Nonaqueous Reverse Micelles. Effect of the Polar Solvent","resumen":"Ver full text","palabras_clave":"NaDEHP|Non-Aqueous Reverse Micelles |Microenvironment; |Micropolarity|QB|FT-IR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17565,"idioma_id":4,"titulo":"Characterization of Cu-Ni nanostructured alloys obtained by a chemical route. Influence of the complexing agent content in the starting solution","resumen":"The influence of the amount of complexing agent added to the starting solution on the physicochemical properties of Cu-Ni nanostructured alloys obtained through a chemical route, was studied. For this purpose, three Cu-Ni nanoalloy samples were synthesized by a previously developed procedure, starting from solutions with citric acid to metal molar ratios (C\/Me) of 0.73, 1.00 and 1.50. The synthesis technique consisted in preparing a precursor via the citrate-gel method, and carrying out subsequent thermal treatments in controlled atmospheres. Sample characterization was performed by scanning electron microscopy, X-ray microanalysis, X-ray diffraction, transmission electron microscopy, X-ray nanoanalysis and electron diffraction. In the three cases, copper and nickel formed a solid solution with a Cu\/Ni atomic ratio close to 50\/50, and free of impurities inside the crystal structure. The citric acid content of the starting solution proved to have an important influence on the morphology, size distribution, porosity, and crystallinity of the Cu?Ni alloy microparticles obtained, but a lesser influence on their chemical composition. The molar ratio C\/Me = 1.00 resulted in the alloy with the Cu\/Ni atomic ratio closest to 50\/50.","palabras_clave":"CuNi alloys|Nanostructured materials|Chemical synthesis|Crystal structure"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17566,"idioma_id":4,"titulo":"Sessile macro-epibiotic community of solitary ascidians, ecosystem engineers in soft substrates of Potter Cove, Antarctica","resumen":"The muddy bottoms that characterize the inner Potter Cove show a high density and richness of macrobenthic species, particularly ascidians. In other areas, ascidians have been reportedto play the role of ecosystem- engineers, as they support a significant number of epibionts,increasing benthic diversity. In this study, a total of 21 sessile macro-epibiotic taxa present on the ascidian species Corella antarctica Sluiter, 1905, Cnemidocarpa verrucosa (Lesson, 1830)and Molgula pedunculata Herdman, 1881 were identified, with Bryozoa being the most diverse.   There were differences between the three ascidian species in terms of richness, percentage cover and diversity of sessile macro-epibionts. The morphological characteristics of the tunic surface,the available area for colonization (and its relation with the age of the basibiont individuals) and the pH of the ascidian tunic, seem to explain the observed differences. Recent environmental changes in the study area (increase of suspended particulate matter caused by glaciers retreat) have been related to observed shifts in the benthic community structure, negatively affecting the abundance and distribution of the studied ascidian species. Considering the diversity of sessile macro-epibionts that settle on these species, the impact of these environmental shifts could be greater than that estimated so far.","palabras_clave":"SESSILE MACRO-EPIBIONTS|ASCIDIAN|ANTARCTICA|ECOSYSTEM- ENGINEER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17567,"idioma_id":5,"titulo":"Pour une littérature-monde en français: notas para una relectura del manifiesto","resumen":"El manifiesto «Pour une littérature-monde en français» (2007) cuestionaba porprimera vez en un medio masivo la diferenciación del corpus de la literatura en lengua francesaactual en términos de categorías de arrastre colonial: literatura francesa y literatura francófona.En este artículo se interroga la lógica suplementaria que vincula a la literatura francófona con lafrancesa a partir del análisis de las polémicas en torno al manifiesto y a los premios literarios enFrancia durante la última década, para examinar las posibilidades y los límites de las nocionesde francofonía y de literatura-mundo en francés. Esta reflexión se concreta en nuestro trabajo através del análisis crítico de la obra Syngué sabour. Pierre de patience del afgano Atiq Rahimi.","palabras_clave":"FRANCOFONÍA|LITERATURAS TRANSNACIONALES|ATIQ RAHIMI|LITERATURA FRANCESA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17568,"idioma_id":4,"titulo":"A versatile mathematical approach for environmental geomechanic modelling based on stress state decomposition","resumen":"The main goal of the present paper is to present a mathematical framework formodelling multi-phase non-saturated soil consolidation with pollutant transport ba-sed on stress state congurations with special emphasis in its versatility conditions.Non-linear saturation and permeability dependence on suction for both water and pollutant transport is regarded. Furthermore, through the introduction of a simple weighting function the implementation of the mutual saturation-suction coupling e\u000Bect is considerably simplied. The achieved di\u000Berential equation system is solved within a Galerkin approach along with the nite element method implementation. A widespread set of practical situations is encompassed by simply setting some matrix coecients of the discrete equation system to certain values and the condition in which this may be carried out is addressed. When the model is put up with certain selected limit circumstances, the approach adaptability feature came up showing a robust performance.","palabras_clave":"non saturated soil consolidation|saturation-suction relationship|pollutant transport"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17569,"idioma_id":4,"titulo":"Biocontrol of Listeria monocytogenes by lactic acid bacteria isolated from brewer's grains used as feedstuff in Argentina","resumen":"Brewer's grains are the most important by-product of the brewery industry and it is mostly used as a protein and energy source in animal nutrition. Listeria monocytogenes is a food-borne pathogen can cause invasive diseases such as meningoencephalitis, sepsis, abortion, and gastroenteritis in humans and several animal species. The aim of this work was to study the antilisterial activity of lactic acid bacteria (LAB) isolated from brewer's grains. The incidence of Listeria spp. in brewer's grains was 3.12%. Twenty-one LAB inhibited the growth of the eight strains of L. monocytogenes. The mean inhibition halo of cell free supernatants of LAB ranged between 11.5 and 24.5 mm. The isolation of lactic acid bacteria with antilisterial activity from brewer's grains is promising based on their capacity to produce antimicrobial compounds. The production of antimicrobial metabolites by LAB in the substrate would generate an unfavorable environment for the growth of the pathogenic bacterium under study.","palabras_clave":"Biocontrol|Lactic acid bacteria|Listeria monocytogenes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17570,"idioma_id":4,"titulo":"Propylene Adsorption On a Non-Stoichiometric VSbO4(110) Surface","resumen":"Density functional theory calculations were performed to investigate propylene adsorption on the nonstoichiometric VSbO4(110) surface. V and Sb sites and two extreme ways of propylene approximation to the surface were considered. Among the six computed configurations, the most stable geometry corresponds to a parallelapproach on the surface on a Sb site. This geometry makes possible a simultaneous adsorption of NH3 on a V site during the ammoxidation reaction to acrylonitrile. Sb(5s and 5p orbitals) interactions with C(2p) from double bond C&#57544;C were found, and no interactions with H atoms of CH3 and CH2 were produced.","palabras_clave":"propilene|vsbo4"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17571,"idioma_id":4,"titulo":"Hydrogen diffusion and trapping in nanocrystalline tungsten","resumen":"The hydrogen behavior in nanocrystalline W (ncW) samples with grain size of 5 and 10 nm is studiedusing Molecular Dynamics (MD) with a bond order potential (BOP) for the W?H system. The dependenceof the hydrogen diffusion coefficient on grain size (5 and 10 nm) and hydrogen concentration(0.1 at.% &lt; [H] &lt; 10.0 at.%) is calculated. These data show that in all cases the hydrogen diffusioncoefficient is lower for ncW than for coarse-grained samples. Trapping energies of grain boundariesare estimated and a broad distribution roughly centered at the vacancy trapping energy is found.Hydrogen diffusion results are interpreted within the trapping model by Kirchheim for nanocrystallinematerials. The H?H interaction is evaluated and the possible formation of H2 is disregarded for theconditions in these simulations. Hydrogen segregation and trapping in grain boundaries for ncW isdiscussed, including extrapolations for micron-sized polycrystals.","palabras_clave":"HYDROGEN DIFFUSION|NANOCRYSTALLINE TUNGSTEN|COMPUTER SIMULATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17572,"idioma_id":5,"titulo":"La sinonimia desde una perspectiva linguistico-cognitiva. Medición de la distancia semántica","resumen":"La sinonimia, entendida como la capacidad de intercambiar dos palabras en un contexto determinado sin que se pierda el significado original, ha presentado una serie de problemas teóricos y técnicos en Lingüística a lo largo del Siglo XX. Ante estas controversias, la medición de la distancia semántica entre palabras se perfila como una vía sugerente para la elucidación de este problema. La perspectiva propuesta coloca la sinonimia como un fenómeno gradual y progresivo. La hipótesis que subyace a este trabajo es que el grado de sinonimia se constituye como un caso extremo de la mayor cantidad de atributos compartidos por el concepto al que hace referencia la palabra. De este modo se estableció la correspondencia entre la sinonimia tal como es presentada en Diccionarios y Tesauros y la sinonimia obtenida experimentalmente a partir de las distancias. Se utilizaron las Normas de Producción de Atributos Semánticos en Castellano obtenidas a partir de 900 jóvenes universitarios. Se obtuvieron las distancias semánticas para 60 palabras pertenecientes a las Normas y a los Diccionarios por medio del cálculo del coseno entre vectores en un espacio n-dimensional para determinar los grados de coincidencia o sinonimia. Las palabras consideradas sinónimos por los diccionarios fluctúan en su distancia semántica entre 0.6 y 0.95 Estos resultados sugieren que las distancias entre los pares considerados sinónimos por los Diccionarios resultó superior a 0.9 cuando pertenecen a una misma subcategoría específica. En las palabras con una distancia próxima a 0.8 se advierte la pertenencia a una misma categoría de base y cuando puntuaron entre 0.6 y 0.8 pertenecen a una misma categoría tomada en un sentido amplio.","palabras_clave":"sinonimia|distancia semántica|atributos semánticos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17573,"idioma_id":4,"titulo":"Developmental exposure to bisphenol a alters the differentiation and functional response of the adult rat uterus to estrogen treatment","resumen":"We assessed the long-term effect of perinatal exposure to bisphenol A (BPA) on the rat uterus and the uterine response to estrogen (E2) replacement therapy. BPA (0.5 or 50&#956;g\/kg\/day) was administered in the drinking water from gestational day 9 until weaning. We studied the uterus of female offspring on postnatal day (PND) 90 and 360, and the uterine E2 response on PND460 (PND460-E2). On PND90, BPA-exposed rats showed altered glandular proliferation and &#945;-actin expression. On PND360, BPA exposure increased the incidence of abnormalities in the luminal and glandular epithelium. On PND460-E2, the multiplicity of glands with squamous metaplasia increased in BPA50 while the incidence of glands with daughter glands increased in BPA0.5. The expression of steroid receptors, p63 and IGF-I was modified in BPA-exposed rats on PND460-E2. The long-lasting effects of perinatal exposure to BPA included induction of abnormalities in uterine tissue and altered response to E2 replacement therapy.","palabras_clave":"Bisphenol A|p63|Steroid receptors|Uterus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17574,"idioma_id":4,"titulo":"Community disassembly and invasion of remnant native grasslands under fluctuating resource supply","resumen":"1. Native vegetation fragments embedded in anthropogenic landscapes are increasingly threatened by land-use intensification. Managing disturbance regimes and nutrient inputs may help maintain species diversity in such remnants. Yet it is unclear the extent to which changes in resource availability due to reduced capture by resident plants and\/or increased supply rates may trigger native community disassembly and exotic invasions.    2. We examined how mowing disturbance and N fertilizer addition affected plant community recovery after a burning event in a remnant corridor of tussock pampa grassland in Argentina. The percentage cover and richness of native and exotic plant functional groups were monitored over four years. According to the ?fluctuating resource theory?, we expected invasion to be highest when both light and N availability were increased simultaneously.     3. Mowing delayed recovery by dominant C4 tussock grasses and promoted subordinate, native C3 grasses and exotic legumes, thus enhancing both native and exotic species richness. Fertilization induced a transient increase in native forbs but decreased total plant richness. Moreover, N addition to mowed grassland led to rapid invasion by short-lived exotic forbs, which were then replaced by exotic perennial grasses. Exotic grasses eventually spread across the grassland corridor, although at different rates depending on the treatment, and in parallel to a generalized decline in native species cover.    4. Synthesis and applications. Community disassembly patterns reflected differential responses of native and exotic functional groups to altered resource supply rates. Synergisms between canopy disturbances and N enrichment posed the greatest threat to preserving a pampa grassland remnant prone to invasion. Establishing buffer zones may be required to enhance the viability of corridor-like grassland remnants in agricultural landscapes.","palabras_clave":"BURNING|DISTURBANCE|FERTILIZATION|FUNCTIONAL GROUPS|INVASION|MOWING|SPECIES RICHNESS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17575,"idioma_id":4,"titulo":"The C-terminal tail of tetraspanin proteins regulates their intracellular distribution in the parasite Trichomonas vaginalis","resumen":"          The  parasite Trichomonas vaginalis is the  causative agent of trichomoniasis, a prevalent sexually transmitted infection. Here,  we report the cellular analysis of T.  vaginalis tetraspanin family  (TvTSPs). This family of membrane proteins has been implicated in cell adhesion,  migration and proliferation in vertebrates. Here we report that the expression  of several members of the family is up-regulated upon contact with vaginal  ectocervical cells (VECs). We demonstrate  that most TvTSPs are localized on the surface and intracellular vesicles and  that the C-terminal intracellular tails of surface TvTSPs are necessary for  proper localization. Analyses of full length TvTSP8 and a mutant that lacks the  C-terminal tail indicates that surface localized TvTSP8 is involved in parasite  aggregation, suggesting a role for this protein in parasite: parasite  interaction.  ","palabras_clave":"TRICHOMONAS VAGINALIS|TETRASPANIN PROTEINS|THE C-TERMINAL TAIL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17576,"idioma_id":5,"titulo":"El Derecho a la educación en Sexualidad en una provincia de Argentina: el desafío de formar a los docentes","resumen":"El artículo refiere a una línea de investigación iniciada en la Facultad de Educación de la Universidad Nacional de Cuyo - Argentina. Tiene el propósito de evidenciar el proceso seguido en la institución y en la provincia de Mendoza desde la sanción de la Ley Nº 26.150  que establece la implementación del Programa Nacional de Educación Sexual Integral en todas las modalidades y niveles del sistema educativo.","palabras_clave":"SEXUALIDAD|EDUCACION|DERECHOS|FORMACIÓN DOCENTE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17577,"idioma_id":4,"titulo":"Quantization Based Simulation of Switched Mode Power Supplies","resumen":"This article studies the performance of Quantized State System (QSS) algorithms in the simulation of Switched Mode Power Supplies (SMPS). Under realistic modeling assumptions, these models result stiff and exhibit frequent discontinuities making them difficult to simulate by classic solvers. However, there are Linearly Implicit QSS (LIQSS) methods that can efficiently handle these types of systems providing faster and more accurate results.&nbsp; In order to corroborate these features, we first built the models corresponding to the different topologies of SMPS, and we analyzed the resulting equation structures in order to establish if they can be efficiently simulated by LIQSS algorithms.Then, we compared the simulation performance of LIQSS and the classic solver DASSL, showing that LIQSS results are from 3 to 200 times faster and noticeably more accurate than DASSL.","palabras_clave":"Hybrid Systems Simulation|Quantized State Systems|Switched Mode Power Supplies"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17578,"idioma_id":4,"titulo":"A mass spectrometry based method for differentiation of positional isomers of monosubstituted pyrazine N-oxides using metal ion complexes","resumen":"A series of 11 pairs of substituted pyrazine N-oxides, differing in the substituent position, were examined using electrospray ionization mass spectrometry (ESI-MS) in order to use spectra to assess the differentiation of positional isomers. For each compound, mass spectra were recorded with three different metal cations, namely calcium (II), copper (II) and aluminum (III), with characterization of the observed peaks. Differentiation between regioisomeric N-oxides has been achieved by comparison of the identity and relative intensities of the peaks originating fromthe adduct ions formed with themetal ions. Principal component analysis (PCA) has been employed to assist in the interpretation of the results obtained with each metal ion, exploring possible trends according to the nature and position of the substituent in the pyrazine N-oxide.","palabras_clave":"PYRAZINE N-OXIDES|POSITIONAL ISOMERS|ELECTROSPRAY|METAL COMPLEXATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17579,"idioma_id":4,"titulo":"Semi-automated mapping of burned areas in semi-arid ecosystems using MODIS time-series imagery","resumen":"International Journal of Applied Earth Observation and Geoinformation j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m \/ l o c a t e \/ j a g: Bushfires Burned area Time series Image segmentation MODIS Normalized burn ratio Rangelands a b s t r a c t Understanding spatial and temporal patterns of burned areas at regional scales, provides a long-term per-spective of fire processes and its effects on ecosystems and vegetation recovery patterns, and it is a key factor to design prevention and post-fire restoration plans and strategies. Remote sensing has become the most widely used tool to detect fire affected areas over large tracts of land (e.g., ecosystem, regional and global levels). Standard satellite burned area and active fire products derived from the 500-m Moderate Resolution Imaging Spectroradiometer (MODIS) and the Satellite Pour l´Observation de la Terre (SPOT) are available to this end. However, prior research caution on the use of these global-scale products for regional and sub-regional applications. Consequently, we propose a novel semi-automated algorithm for identification and mapping of burned areas at regional scale. The semi-arid Monte shrublands, a biome covering 240,000 km 2 in the western part of Argentina, and exposed to seasonal bushfires was selected as the test area. The algorithm uses a set of the normalized burned ratio index products derived from MODIS time series; using a two-phased cycle, it firstly detects potentially burned pixels while keeping a low commission error (false detection of burned areas), and subsequently labels them as seed patches. Region growing image segmentation algorithms are applied to the seed patches in the second-phase, to define the perimeter of fire affected areas while decreasing omission errors (missing real burned areas). Independently-derived Landsat ETM+ burned-area reference data was used for validation purposes. Addi-tionally, the performance of the adaptive algorithm was assessed against standard global fire products derived from MODIS Aqua and Terra satellites, total burned area (MCD45A1), the active fire algorithm (MOD14); and the L3JRC SPOT VEGETATION 1 km GLOBCARBON products. The correlation between the size of burned areas detected by the global fire products and independently-derived Landsat reference data ranged from R 2 = 0.01?0.28, while our algorithm performed showed a stronger correlation coefficient (R 2 = 0.96). Our findings confirm prior research calling for caution when using the global fire products locally or regionally.","palabras_clave":"Bushfires|Burned area|Time series|Image segmentation|MODIS Normalized burn ratio|Rangelands"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17580,"idioma_id":4,"titulo":"Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation","resumen":"Arsenic (As) is one of the most toxic naturally occurring contaminants in the environment. The major source of human exposure to inorganic As (iAs) is through contaminated drinking water. Although both genotoxicity and carcinogenicity derived from this metalloid have been thoroughly studied, the effects of iAs on the development and function of the central nervous system (CNS) have received less attention and only a few studies have focused on neurobehavioral effects. Thus, in order to characterize developmental and behavioral alterations induced by iAs exposure, pregnant Wistar rats were exposed to 0.05 and 0.10 mg\/L iAs through drinking water during gestation and lactation. Sensory-motor reflexes in each pup were analyzed and the postnatal day when righting reflex, cliff aversion and negative geotaxis were observed was recorded. Functional Observational Battery (FOB) and locomotor activity in an open field were assessed in 90-day-old offspring. Results show that rats exposed to low iAs concentrations through drinking water during early development evidence a delay in the development of sensory-motor reflexes. Both FOB procedure and open-field tests showed a decrease in locomotor activity in adult rats. This study reveals that exposure to the above-mentioned iAs concentrations produces dysfunction in the CNS mechanisms whose role is to regulate motor and sensory development and locomotor activity.","palabras_clave":"ARSENIC|DEVELOPMENT EXPOSURE|SENSORY-MOTOR REFLEXES|FUNCTIONAL OBSERVATIONAL BATTERY|LOCOMOTOR ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17581,"idioma_id":4,"titulo":"Prediction of infiltration on small scale field tests performance in compacted loessic soil","resumen":"Silty loess soils are widely spread on Córdoba city, Argentina. The ability to use this soil improved by compaction on embankments it is of interest to different types of local constructions, with purpose of reducing settlements and infiltration. This work research the water infiltration through compacted silty soils from Córdoba by small scale field test. Four small test embankments were constructed on natural soil with different compaction conditions using local silty soils. The site was characterized by typical geotechnical laboratory and field tests. The infiltration tests were performed using double ring infiltrometers for a time period around of 2 months. Results were used to field permeability estimated (kf) and these were compared with laboratory results (kl). Conclusions regarding the behavior observed in the field are presented.","palabras_clave":"Embankment|Ring|Infiltrometers"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17582,"idioma_id":4,"titulo":"REVISED AND EXTENDED ANALYSIS OF FIVE TIMES IONIZED XENON, Xe VI","resumen":"A capillary discharge tube was used to record the Xe spectrum in the 400?5500Å region. A set of 243 lines of theXe vi spectrum was observed, and 146 of them were classified for the first time. For all known lines, we calculatedthe weighted oscillator strengths (gf ) and weighted transition probabilities (gA) using the configuration interactionin a relativistic Hartree?Fock approach. The energy matrix was calculated using energy parameters adjusted to fitthe experimental energy levels. Core polarization effects were taken into account in our calculations. Experimentalenergy values and calculated lifetimes are also presented for a set of 88 levels. From these levels, 32 were classifiedfor the first time and 33 had their values revised. Our analysis of the 5s5p5d and 5s5p6s configurations wasextended in order to clarify discrepancies among previous works.vi spectrum was observed, and 146 of them were classified for the first time. For all known lines, we calculatedthe weighted oscillator strengths (gf ) and weighted transition probabilities (gA) using the configuration interactionin a relativistic Hartree?Fock approach. The energy matrix was calculated using energy parameters adjusted to fitthe experimental energy levels. Core polarization effects were taken into account in our calculations. Experimentalenergy values and calculated lifetimes are also presented for a set of 88 levels. From these levels, 32 were classifiedfor the first time and 33 had their values revised. Our analysis of the 5s5p5d and 5s5p6s configurations wasextended in order to clarify discrepancies among previous works.gf ) and weighted transition probabilities (gA) using the configuration interactionin a relativistic Hartree?Fock approach. The energy matrix was calculated using energy parameters adjusted to fitthe experimental energy levels. Core polarization effects were taken into account in our calculations. Experimentalenergy values and calculated lifetimes are also presented for a set of 88 levels. From these levels, 32 were classifiedfor the first time and 33 had their values revised. Our analysis of the 5s5p5d and 5s5p6s configurations wasextended in order to clarify discrepancies among previous works.s5p5d and 5s5p6s configurations wasextended in order to clarify discrepancies among previous works.","palabras_clave":"PHYSICS|ATOMIC PHYSICS|OPTIC|OPTICAL SPECTROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17583,"idioma_id":4,"titulo":"NEW SPECTROSCOPIC DATA FOR ATOMIC TUNGSTEN XIV","resumen":"The thirteen times ionized tungsten is isoelectronic with PmI. Wavelengths andtransition probabilities for the 5s-5p and 5p-5d transitions of WXIV, identifying the groundstate as 4f13 5s2 2F7\/2 were calculated. Both, a relativistic Hartree Fock approach, including core-polarization effects, and a purely relativistic multiconfiguration Dirac-Fock method wereused for the calculations. Particularly, 5s-5p transitions were compared with experimentalresults obtained with VUV electron beam ion trap (EBIT) spectroscopy.core-polarization effects, and a purely relativistic multiconfiguration Dirac-Fock method wereused for the calculations. Particularly, 5s-5p transitions were compared with experimentalresults obtained with VUV electron beam ion trap (EBIT) spectroscopy.13 5s2 2F7\/2 were calculated. Both, a relativistic Hartree Fock approach, including core-polarization effects, and a purely relativistic multiconfiguration Dirac-Fock method wereused for the calculations. Particularly, 5s-5p transitions were compared with experimentalresults obtained with VUV electron beam ion trap (EBIT) spectroscopy.trap (EBIT) spectroscopy.","palabras_clave":"PHYSICS|ATOMIC PHYSICS|OPTICS|OPTICAL SPECTROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17584,"idioma_id":4,"titulo":"Oviductal secretion and gamete interaction","resumen":"Experimental evidence from the last 30 years supports the fact that the oviduct is involved in the modulation of the reproductive process in eutherian mammals. Oviductal secretion contains molecules that contribute to regulation of gamete function, gamete interaction, and the early stages of embryo development. The oviductal environment would act as a sperm reservoir, maintaining sperm viability, and modulating the subpopulation of spermatozoa that initiates the capacitation process. It could also contribute to prevent the premature acrosome reaction and to reduce polyspermy. Many studies have reported the beneficial effects of the oviductal environment on fertilization and on the first stages of embryo development. Some oviductal factors have been identified in different mammalian species. The effects of oviductal secretion on the reproductive process could be thought to result from the dynamic combined action (inhibitory or stimulatory) of multiple factors present in the oviductal lumen at different stages of the ovulatory cycle and in the presence of gametes or embryos. It could be hypothesized that the absence of a given molecule would not affect fertility as its action could be compensated by another factor with similar functions. However, any alteration in this balance could affect certain events of the reproductive process and could perhaps impair fertility. Thus, the complexity of the reproductive process warrants a continuous research effort to unveil the mechanisms and factors behind its regulation in the oviductal microenvironment.","palabras_clave":"OVIDUCT|GAMETE|SECRETION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17585,"idioma_id":4,"titulo":"Agent-based monitoring service for management of disruptive events in supply chains","resumen":"Schedules of supply chains are generated with buffers to absorb the effect of disruptive events that can occur during their execution. Schedules can be systematically repaired through specific modifications within buffers by using appropriate decision models that consider the distributed nature of a supply chain. To this aim, information of disruptive events at occurrence or in advance allows making better decisions. To detect and predict disruptive events along a schedule execution, a service-oriented Monitoring Subsystem was proposed. The main services offered by this subsystem are: provision of a reference model for defining tailored monitoring models, retrieval of already defined  monitoring models, collection of execution data of a schedule and environment data for detecting disruptive events, and monitoring of schedules either reactively or predictively. Because of the complexity of these services functionalities, this paper presents an agent-based approach for their implementation. This technology allows dealing with the complexity of monitoring services by structuring their functionalities as a set of autonomous entities. These entities are able to perform tailored plans created at execution time to concurrently monitor different schedules. A case study is described to try out the implemented prototype system.","palabras_clave":"MULTIAGENT SYSTEM|DISRUPTIVE EVENT|SUPPLY CHAIN|MONITORING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17586,"idioma_id":5,"titulo":"Modelo de redes funcionales orientado a pronóstico de crecidas en cursos de llanura del Gran Rosario, Santa Fe, Argentina","resumen":"Se presentan diferentes modelos de redes funcionales orientados a pronóstico de niveles, que fueron aplicados en cuencas del Gran Rosario. Las variables de entrada son precipitación y nivel vinculado a un tiempo t0 , mientras que la salida está dada por niveles asociados a diferentes horizontes temporales tpi. A partir de los eventos observados, en promedio 10 tormentas sobre 15 estaciones limnimétricas, se calculan las combinaciones posibles para constituir dos grupos: uno para aprendizaje yotro para validación de la red. La evaluación de los modelos se efectúa por medio de distintos estadísticos, entre ellos: diferencia máxima en el nivel pico (Dpico), coeficiente de eficiencia de Nash-Sutcliffe (NS) y raíz del error cuadrático medio (RECM). Para los cuatro limnímetros presentados en este trabajo el valor de Dpico varía entre 0,04 m y 1,07 m, el de NS varía entre 0,99 y 0,75 y el de RECM fluctúa entre 0,03 m y 0,32 m, para tiempos de pronóstico desde 15 minutos hasta 6 horas respectivamente. Este tipo de modelos puede ser implementado en cualquier cuenca que posea datos de precipitación y niveles. Los resultados obtenidos hasta el presente son favorables, demostrando la capacidad de ?aprendizaje? y simulación de eventos de estos modelos.","palabras_clave":"MODELOS DE CAJA NEGRA|REDES FUNCIONALES|PRONOSTICO DE NIVELES|CUENCAS DE LLANURA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17587,"idioma_id":4,"titulo":"Loading of Cells with Fluorescent Probe to Study Intracellular Acid-base Homeostasis in Lactic Acid Bacteria","resumen":"        Here we describe a  protocol which we have used to study the homeostasis intracellular in vivo in Lactic Acid Bacteria (LAB) using a fluorescent probe. The use of these probes for determiningchanges in the pH cytoplasm with high sensitivity, temporal resolution and ease of use to assess the rate of change of cell pH in responseto a stimulus from kinetic measurements on short time scales  (Breeuwer et al., 1996; Molenaar et al., 1991). This protocol has been  designed to measure the in-vivo  intracellular pH using the pH-sensitive fluorescent  probe 2´,7´-bis-(2-carboxyethyl)-5(and-6)-carboxyfluorescein (BCECF) in LAB,  Enterococcus faecalis (E.  faecalis), Lactococcus lactis (L. lactis) and Lactobacillus  casei (L. casei).     ","palabras_clave":"Acid-base homeostasis|Ion analysis|Lactic Acid Bacteria"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17588,"idioma_id":4,"titulo":"Effect of arsenic on tolerance mechanisms of two plant growth promoting bacteria used as biological inoculants","resumen":"Bacterial ability to colonize the rhizosphere of plants in arsenic (As) contaminated soils is greatly important for symbiotic and free-living plant growth-promoting rhizobacteria (PGPR) used as inoculants, since they can contribute to enhance plant As tolerance and limit metalloid uptake by plants. The aim of this work was to study the effect of As on growth, exopolysaccharides (EPS) production, biofilm formation and motility of two strains used as soybean inoculants, Bradyrhizobium japonicum E109 and Azospirillum brasilense Az39. The metabolism of arsenate (AsV) and arsenite (AsIII) and their removal and\/or possible accumulation were also evaluated. The behaviour of both bacteria under As treatment was compared and discussed in relation to their potential of colonizing plant rhizosphere with high content of the metalloid. B. japonicum E109 growth was reduced with AsIII concentration from 10 µM while A. brasilense Az39 showed reduction of growth with AsIII from 500 µM. EPS and biofilm production increased significantly under 25 µM AsIII for both strains. Moreover, this was more notorious for Azospirillum under 500 µM AsIII, where motility was seriously affected. Both bacterial strains showed similar ability to reduce AsV, however Azospirillum was able to oxidize more AsIII (around 53%) than Bradyrhizobium (17%). In addition, both strains accumulated As in cell biomass. The behavior of Azospirillum under As treatments suggests that this strain would be able to efficiently colonize As contaminated soils. In this way, inoculation with A. brasilense Az39 would positively contribute to promoting growth of different plant species under As treatment and it could also be used for co-inoculation of soybean plants, commonly inoculated with B. japonicum E109, which is seriously affected by As.","palabras_clave":"ARSENIC|INOCULANTS|PGPR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17589,"idioma_id":4,"titulo":"A note on annihilators in distributive nearlattices","resumen":"In this note we propose a definition of relative annihilator in distributive nearlattices with greatest element different to that given in [5] and we present some new characterizations of the distributivity. Later, we study the class of normal and p-linear nearlattices, the lattice of filters and semi-homomorphisms that preserve annihilators.","palabras_clave":"DISTRIBUTIVE NEARLATTICE|RELATIVE ANNIHILATOR|PRIME IDEAL|SEMI-HOMOMORPHISM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17590,"idioma_id":4,"titulo":"Pesticide Exposure and Health Conditions of Terrestrial Pesticide Applicators in Córdoba Province, Argentina","resumen":"Agricultural workers represent a population that is highly vulnerable to the toxic effects of pesticide exposure. This cross sectional study aimedto describe the health conditions of terrestrial pesticide applicators in Córdoba Province, Argentina, their work practices and socio-demographiccharacteristics, by means of a standardized self-administered questionnaire (n = 880). A descriptive analysis reported a high prevalence of occasional or frequent symptoms: 47.4% had symptoms of irritation, 35.5% fatigue, 40.4% headache and 27.6% nervousness or depression. Using logistic regression models, risk and protectivefactors were found for symptoms of irritation, medical consultation and hospitalization. Among the occupational exposure variables,  marital status, length of time in the job, low level of protection with regard to the use of personal protective equipment, combined use of differentpesticides and the application of the insecticide endosulfan, were associated with a higher frequency of reported symptoms and higher consultation rates and hospitalization","palabras_clave":"Pesticides|Occupational DiseaseseOccupational Exposure|Occupational Exposure"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17591,"idioma_id":4,"titulo":"Building of a sulfonyl-group-functionalized monomer whose polymer is able to catalyze biodiesel formation","resumen":"A linear polymer containing sulfonyl groups was synthesized from a vinyl monomer to use its acid group as a catalyst of  the esterification of oleic acid to form biodiesel. First, synthesis optimization of the monomer was carried out in an aqueous system.  This molecule was obtained in an excellent yield, where the pH and reaction time were decisive factors in the synthesis performance.  The vinyl monomer was then polymerized, and the catalytic activity of the sulfonic acid could be demonstrated in the esterification of  oleic acid with short-chain alcohols. The increase in the catalyst content resulted in a higher concentration of the carbonyl group activated,  and this was followed by faster esterification kinetics. The highest yield (98 mol %) was reached after 20 min when a 10 mol-%  of catalyst was used. A larger size alcohol led to slower esterification kinetics because its ability as a nucleophile was decreased by steric  impediment. The sulfonyl group in polymer 4, an aryl sulfonic acid polymer, proved to be an acid almost as efficient as sulfuric acid,  although the former worked in a heterogeneous system.","palabras_clave":"CATALYSTS|FUNCTIONALIZATION|BIODIESEL|SYNTHESIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17592,"idioma_id":4,"titulo":"Sex differences in feed intake, behavior and weight gained by Greater Rheas (Rhea americana) in captivity during the pre-reproductive season","resumen":"The use of common rhea, Rhea americana, as breeding bird requires knowledge of nutritional physiology. It is important the analysis jointly of feed intake, behavior and weight gain. Our objective was to determine and analyze differences in the feed intake, weight gained and behavior of captive subadults and adults male and female rheas during autumn and winter in the Humid Pampas, Argentina. Neither males nor females showed  significant seasonal differences in the weights with which they initiated the trials. Daily feed consumption didn?t show significant differences neither between seasons nor between sexes. However, we observed differences in weight gain by males between seasons and during the autumn trial, the weight gain was higher for males. Rhea behavior also varied  seasonally. Males and females spent more time preening and resting than walking and feeding during autumn, the opposite occurred in winter. The males had a higher tendency towards walking than to feeding, the females showed the opposite in autumn. Analyzing the feed intake, weight gained and the time spent on feeding we hypothesized that males are more efficient for feeding. This analysis allowed us to observe there are  nutritional issues that can be explained from a behavioral point of view.","palabras_clave":"RHEA AMERICANA|FEED INTAKE|BEHAVIOR|WEIGHT GAIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17593,"idioma_id":4,"titulo":"Rapid Fabrication of Periodic Patterns on Poly (Styrene-co-Acrylonitrile) Surfaces  Using Direct Laser Interference Patterning","resumen":"Periodic microstructures in styrene-acrylonitrile (SAN) copolymers are fabricated by two-beam direct laser interference patterning using a nanosecond pulsed laser operating at a wavelength of 266 nm. The SAN copolymers are synthesized using different molar ratios (styrene to acrylonitrile) by a free radical polymerization process. The chemical composition of the copolymers and their properties are determined using Fourier transformed infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Depending on the composition of the irradiated copolymer films, with weight ratios ranging from 58 to 96.5% of styrene to acrylonitrile, different ablation behaviors are observed. The laser fluence necessary to locally ablate the copolymer is found to be dependent on the copolymer composition. Unlike other dielectric polymers, the laser irradiation produced both direct ablation of the irradiated material and collapse of the surface. It is shown that, by varying the laser fluence and the copolymer composition, the surface structure can be changed from a periodic pattern with a swelled topography to an ablated-like structure. The number of holes does not depend monotonically on the amount of PS or PAN units but shows a more complex behavior which depends on the copolymer composition and the laser fluence.","palabras_clave":"estructuracion|laser|copolimeros"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17594,"idioma_id":4,"titulo":"Hydraulic conductivity in loessic stabilized soil","resumen":"Loessic soils are the main geological storage available as a building material in Cordoba, Argentina. They are a typically kind of clayed silty soil with a metastable structure. Their structure makes them sensitive to collapse and sliding upon wetting. This has an important influence on mechanical and hydraulic behavior. Thus, usually their hydraulic properties are modified by compaction methods or by bentonite addition. Infiltration tests were done using remolded samples and a flexible wall permeameter. Compression tests were executed in a universal compression machine. Were performed in addition, capillary rise assays. Water content, dry unit weight, and percentages of ionic stabilizer and bentonite have been studied. Experiment results were compared between mixtures with different percentages of additives. The results show that the infiltration volume decreases with increasing content of bentonite in all remoulded samples tested respect to those natural soil remoulded samples, and it has been identified that the addition of bentonite increases the compressive strength by 400%.","palabras_clave":"SILT|INFILTRATION|PERMEAMETER|FALING-HEAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17595,"idioma_id":4,"titulo":"Virtual Scrum: A Teaching Aid to Introduce Undergraduate Software Engineering Students to Scrum","resumen":"Teaching agile practices is becoming a priority in Software engineering curricula as a result of the increasing use of agile methods such as Scrum in the software industry. Limitations in time, scope and facilities within academic contexts hinder students? hands-on experience in the use of professional agile methods. To enhance students? exposure to Scrum, we have developed Virtual Scrum, an educational virtual world that simulates a Scrum-based team room through virtual elements such as blackboards, a Web browser, document viewers, charts, and a calendar. A preliminary version of Virtual Scrum was tested with a group of 45 students running a capstone project with and without Virtual Scrum support. Students? feedback showed that Virtual Scrum is a viable and effective tool to implement the different elements in a Scrum team room and to perform activities throughout the Scrum process.","palabras_clave":"Software Engineering Education| Agile Methodologies|Scrum|Virtual Worlds"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17596,"idioma_id":5,"titulo":"La intervencion interdisciplinaria en Salud Mental, lo que la ley no puede resolver","resumen":"El trabajo pretende socializar algunos hallazgos en el marco de la investigación  que se realiza en el ámbito de la Secretaria de Investigación y Posgrado de la Facultad de Humanidades y Ciencias Sociales (UNaM). El proyecto se plantea como objetivo conocer, describir y analizar  las estrategias de abordaje interdisciplinar y comunitario que construyen los equipos profesionales que se encuentran desarrollando actividades en la Provincia de Misiones, en el marco de la Ley Nacional de Salud Mental N°26657\/10.","palabras_clave":"SALUD MENTAL|INTERDISCIPLINARIEDAD|LEY NACIONAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17597,"idioma_id":4,"titulo":"Further Evidence for the Neuroplastic Role of Cannabinoids: A Study in Organotypic Hippocampal Slice Cultures","resumen":"Endocannabinoid receptors CB1R and CB2R are present in the CNS and modulate synaptic activity. By using an in vitro model, two concentrations of CB1R agonist ACEA at 0.5 and 5 &#956;M doses and CB1R antagonist AM251 at 1 and 10 &#956;M doses were administered in organotypic slice cultures of mouse hippocampus, and their effects on neurons and glial cells were analyzed at different time points. Exposure to low concentrations of ACEA (0.5 &#956;M) did not seem to affect tissue organization, neuronal morphology, or glial response. In contrast, at a higher concentration of ACEA, many neurons in the dentate gyrus exhibited strong caspase-3 immunoreactivity. After treatment with AM251, we observed an increase in caspase-3 immunoreactivity and a downregulation of CB1R expression. Results show that long-term hippocampal slice cultures respond to both CB1R activation and inactivation by changing neuronal protein expression patterns. In the present study, we demonstrate that CB1R agonist ACEA promotes alterations in the neuronal cytoskeleton as well as changes in CB1R expression in organotypic hippocampal slice cultures, and that CB1R antagonist AM251 promotes neuronal death and astroglial reaction.","palabras_clave":"Cannabinoids |Neuron|Neurotoxicity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17598,"idioma_id":4,"titulo":"Radial oxygen loss and physical barriers in relation to root tissue age in species with different types of aerenchyma","resumen":"Plant root aeration relies on aerenchyma and barrier formation in outer cortex influencing the radial oxygen loss (ROL) from roots towards the rhizosphere. Plant species display large variation in strategies for both responses. We investigated the impacts of root-zone hypoxia on aerenchyma formation and development of ROL apoplastic barriers in the outer cortex as a function of root tissue age using three lowland grassland species, each with alternative aerenchyma structure. All species increased root aerenchyma and continued with root elongation after imposing hypoxia. However, ROL barrier development differed: (i) Rumex crispus L. displayed only ?partial? barrier to ROL evidenced at older tissue ages, (ii) Cyperus eragrostis Lam. initiated a ?tighter? barrier to ROL following exposure to hypoxia in tissues older than 3 days, and (iii) Paspalidium geminatum (Forssk.) Stapf demonstrated highly effective inhibition of ROL under aerated and hypoxic conditions at all tissue ages related to constitutive ?tight? apoplastic barriers in outer cortex. Thus, hypoxic conditions affected root elongation and ?tightness? of apoplastic barriers depending on species. The physiological implications of the different ROL responses among species in relation to the differential formation of barriers are discussed.","palabras_clave":"Apoplastic barriers|hipoxia|Cyperus eragrostis|Rumex crispus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17599,"idioma_id":4,"titulo":"Synthesis of ultra-small cysteine-capped gold nanoparticles by pH switching of the Au(I)-cysteine polymer","resumen":"We report a synthetic approach for the production of ultra-small (0.6 nm) gold nanoparticles soluble in water with a precise control of the nanoparticle size. Our synthetic approach utilizes a pH-depending Au?cysteine polymer as a quencher for the AuNPs grown. The method extends the synthetic capabilities of nanoparticles with sizes down to 1 nm. In addition to the strict pH control, the existence of free ?SH groups present in the mixture of reaction has been observed as a key requirement for the synthesis of small nanoparticles in mild conditions. UV?Vis, SAXS, XANES, EXAFS and HR-TEM, has been used to determinate the particle size, characterization of the gold precursor and gold?cysteine interaction.","palabras_clave":"Gold nanoparticles|Cysteine|SAXS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17600,"idioma_id":4,"titulo":"On the design of Pt based catalysts. Combining porous architecture with surface modification by Sn for electrocatalytic activity enhancement","resumen":"Metallic mesoporous (MP) catalysts with large surface area can be obtained in-situ, in a single step, by (MPPt\/Sn) was studied and compared with commercial carbon supported PtSn alloy (3:1). The electrochemical activity toward carbon monoxide and methanol oxidation reactions were evaluated by cyclic voltammetry and chronoamperometry, whereas X-ray photoelectron spectroscopy was used to determine the surface composition and oxidation state of the atoms in the top layers of the catalysts. The analysis of methanol conversion to CO2 was performed with aid of differential electrochemical mass spectrometry (DEMS). Results reveal a better performance of the MPPt\/Sn, which shows higher current density and energy conversion efficiency of fuel to CO2 than conventional carbon supported PtSn alloy(3:1).","palabras_clave":"DMFC|DEMS|Mesoporous electrodes|CO oxidation|Methanol oxidation|Pt-based materials"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17601,"idioma_id":4,"titulo":"Biology of Myliobatis goodei (Springer, 1939) a widely distributed eagle ray caught in northern Patagonia","resumen":"Chondrichthyans play an important role in structuring marine communities. Myliobatis goodie is an eagle ray reported from South Carolina in USA (35°N) to Santa Cuz, Argentina (44°S), however little is known about this species, which is considered Data Deficient by the IUCN. In order to create adequate management strategies for this species, biological information is sorely needed. The objective of this study was to describe the biology of the population of M. goodei and its relationships with season, sex and the geographic features of Anegada Bay, Argentina (from 39.96°S to 40.60°S and from 62.10°W to 62.46°W) during 2008. Specifically, the population structure of M. goodie was studied by sex, seasons and sites, its food habits by seasons and sites, and the reproductive biology by seasons and sex. The results show that M. goodei exhibits seasonal migrations. Young-of-the-year remain in the bay all year long, while adults enter during spring and summer. Juveniles in spring are likely to become first-time mating individuals that migrate into open sea at the end of summer. These individuals would return to give birth for the first time and mate for the second time during the next year at summer. Anegada Bay would then be a mating and nursery area for the species. M. goodei behave as a generalist feeder with a uniform diet composed mainly of bivalves. Seasonal differences in the diet found arise from differences in prey diversity between summer and spring. Spatial differences, however, arise from the different abundances of caprelids and bivalves. Trophic level was 3.2 and it constitutes the first reference for this species, characterizing it as a secondary consumer.","palabras_clave":"Myliobatis goodei|Reproductive parameters|Trophic ecology|Elasmobranches|Patagonia|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17602,"idioma_id":4,"titulo":"Working memory training triggers delayed chromatin remodeling in the mouse corticostriatothalamic circuit","resumen":"            Working  memory is a cognitive function serving goal-oriented behavior. In the last  decade, working memory training has been shown to improve performance and its  efficacy for the treatment of several neuropsychiatric disorders has begun to  be examined. Neuroimaging studies have contributed to elucidate the brain areas  involved but little is known about the underlying cellular events. A growing  body of evidence has provided a link between working memory and relatively  long-lasting epigenetic changes. However, the effects elicited by working  memory training at the epigenetic level remain unknown.             In this  study we establish an animal model of working memory training and explore the changes  in histone H3 acetylation (H3K9,14Ac) and histone H3 dimethylation on lysine 27  (H3K27Me2) triggered by the procedure in the brain regions of the  corticostriatothalamic circuit (prelimbic\/infralimbic cortex (PrL\/IL),  dorsomedial striatum (DMSt) and dorsomedial thalamus (DMTh)).             Mice trained  on a spontaneous alternation task showed improved alternation scores when  tested with a retention interval that disrupts the performance of untrained  animals. We then determined the involvement of the brain areas of the corticostriatothalamic  circuit in working memory training by measuring the marker of neuronal  activation c-fos. We observed increased c-fos levels in PrL\/IL and DMSt in  trained mice 90 min after training. These animals also presented lower immunoreactivity  for H3K9, 14Ac in DMSt 24 h but not 90 min after the procedure. Increases in  H3K27Me2, a repressive chromatin mark, were found in the DMSt and DMTh 24 h  after the task.   Altogether,  we present a mouse model to study the cellular underpinnings of working memory training  and provide evidence indicating delayed chromatin remodeling towards repression  triggered by the procedure.","palabras_clave":"WORKING MEMORY|EXCECUTIVE FUNCTION|HISTONE ACETYLATION|HOSTONE METHYLATION|C-FOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17603,"idioma_id":4,"titulo":"Jet energy measurement and its systematic uncertainty in proton--proton collisions at s&#8730;=7~TeV with the ATLAS detector","resumen":"The jet energy scale (JES) and its systematic uncertainty are determined forjets measured with the ATLAS detector using proton-proton collision data with acentre-of-mass energy of s&#8730;=7 TeV corresponding to an integratedluminosity of 4.7 fb&#8722;1. Jets are reconstructed from energy depositsforming topological clusters of calorimeter cells using the anti-ktalgorithm with distance parameters R=0.4 or R=0.6, and are calibrated usingMC simulations. A residual JES correction is applied to account for differencesbetween data and MC simulations. This correction and its systematic uncertaintyare estimated using a combination of in situ techniques exploiting thetransverse momentum balance between a jet and a reference object such as aphoton or a Z boson, for 20&lt;pT&lt;1000 GeV and pseudorapidities|&#951;|&lt;4.5. The effect of multiple proton-proton interactions is correctedfor, and an uncertainty is evaluatedusing in situ techniques. The smallest JESuncertainty of less than 1 is found in the central calorimeterregion(|&#951;|&lt;1.2) for jets with 55&lt;pT&lt;500 GeV. For central jets atlower pT, the uncertainty is about 3. A consistent JES estimate is foundusing measurements of the calorimeter response of single hadrons inproton-proton collisionsand test-beam data, which also provide the estimate forpT,jet&gt;1 TeV. The calibration of forward jets is derived from dijetpT balance measurements. The resulting uncertainty reaches its largest valueof 6 for low-pT jets at |&#951;|=4.5.Additional JES uncertainties due to specific event topologies, such asclose-by jets or selections of event samples with an enhanced content of jetsoriginating from light quarks or gluons, are also discussed. The magnitude ofthese uncertainties depends on the event sample used in a given physicsanalysis, but typically amounts to 0.5 to 3.","palabras_clave":"ATLAS|jet|calorimeter|calibration"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17604,"idioma_id":4,"titulo":"Transition metal-modified polyoxometalates supported on carbon as catalyst in 2-(methylthio)-benzothiazole sulfoxidation","resumen":"Polyoxometalates with  lacunary Keggin structure modified with transition metal ions [PW11O39M(H2O)]5-,  where M= Ni2+, Co2+, Cu2+or Zn2+,  were synthesized and supported on activated carbon to obtain the PW11MC  catalysts. By FT-IR and DTA-TGA it was concluded that the [PW11O39M(H2O)]5-  species are interacting with the functional groups of the support,  and that the thermal treatment leads to the  loss of the coordinatively bonded water molecules, without any noticeable anion  degradation. The activity and selectivity of the catalysts in the sulfoxidation  reaction of 2-(methylthio)-benzothiazole, an emerging environmental pollutant, were evaluated. The  reaction was carried out in acetonitrile as solvent using H2O2  35% p\/v as a clean oxidant. The conversion values decreased in the following  order: PW11NiC > PW11CuC > PW11CoC > PW11ZnC, with selectivities to  sulfoxide higher than 69%. The catalyst could be reused without appreciable  loss of the catalytic activity at least three times. The materials were found  to be efficient and recyclable catalysts for 2-(methylthio)-benzothiazole sulfoxidation in order to obtain a more biodegradable product than the corresponding substrate.","palabras_clave":"Supported metal-substituted polyoxometalates| carbon|sulfoxidation, 2-(methylthio)-benzothiazole oxidation|hydrogen peroxide"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17605,"idioma_id":4,"titulo":"Cyclodextrin glycosyltransferase production by free cells of Bacillus circulans DF 9R in batch fermentation and by immobilized cells in a semi-continuous process","resumen":"Cyclodextrin glycosyltransferase (CGTase) catalyzes the starch conversion into cyclic or linear oligosaccharides, important industrial products. In this work, conditions to increase the enzyme production from Bacillus circulans strain DF 9R were optimized by two systems. On one hand, free cells were grown in batch fermentation experiments conducted to optimize aeration and pH. The increased production of the enzyme was achieved with aeration of 1.5 vvm at pH regulated to 7.6 after 48 h of growth. On the other hand, bacterial cells were immobilized on vegetable and synthetic sponge and used for CGTase production in a semi-continuous process, by transferring the immobilized cells to a suitable culture medium in successive cycles. An initial biomass of 30 mg of lyophilized cells and an immobilization time of 24 h with vegetal or synthetic sponge was enough to reach the greater production of the CGTase. Sponge immobilized bacteria were re-used in 12 successive cycles, although enzyme production dropped significantly after the sixth cycle reaching around 40 % of initial enzyme activity. Even though the specific productivity was similar in both processes, the semi-continuous process has advantages compared to batch process with free cells because employed an inexpensive and biodegradable matrix, thus making the system potentially appropriate for CGTase production on an industrial scale.","palabras_clave":"CYCLODEXTRIN GLYCOSYLTRANSFERASE|FERMENTATION|IMMOBILIZED CELLS|VEGETABLE SPONGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17606,"idioma_id":4,"titulo":"Continuous production of cyclodextrins in an ultrafiltration membrane reactor, catalyzed by Cyclodextrin glycosyltransferase from Bacillus circulans DF 9R","resumen":"Cyclodextrins (CDs) are cyclic oligosaccharides of wide industrial application, whose synthesis is catalyzed by Cyclodextrin glycosyltransferase (CGTase) from starch. Here, CDs were produced using CGTase from Bacillus circulans DF 9R in continuous process and an ultrafiltration membrane reactor. The batch process was conducted as a control. This method allowed increasing the yield from 40% to 55.6% and the productivity from 26.1 to 99.5 mg of CD per unit of enzyme. The method also allowed obtaining a high purity product. The flow rate remained at 50% of its initial value after 24 hours of process, improving the results described in the literature for starch hydrolysis processes. CGTase remained active throughout the process, which could be explained by the protective effect of the substrate and reaction products on CGTase stability. In addition, batch processes were developed using starches from different sources. We concluded that any of the starches studied could be used as substrate for CD production with similar yields and product specificity.","palabras_clave":"CYCLODEXTRINS|CYCLODEXTRINS GLYCOSYLTRANSFERASE|BACILLUS CIRCULANS|STARCH CONVERSION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17607,"idioma_id":4,"titulo":"Design, fabrication and metrological evaluation of wearable pressure sensors","resumen":"Pressure sensors are valuable transducers that are necessary in a huge number of medical application. However, the state of the art of compact and lightweight pressure sensors with the capability of measuring the contact pressure between two surfaces (contact pressure sensors) is very poor. In this work, several types of wearable contact pressure sensors are fabricated using different conductive textile materials and piezo-resistive films. The fabricated sensors differ in size, the textile conductor used and\/or the number of layers of the sandwiched piezo-resistive film. The intention is to study, through the obtaining of their calibration curves, their metrological properties (repeatability, sensitivity and range) and determine which physical  characteristics improve their ability for measuring contact pressures. It has been found that it is possible to obtain wearable contact pressure sensors through the proposed fabrication process with satisfactory repeatability, range and sensitivity; and that some of these properties can be improved by the physical characteristics of the sensors.","palabras_clave":"Metrological properties|pressure sensors|wearability"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17608,"idioma_id":4,"titulo":"Cuticle Fatty Acid Composition and Differential Susceptibility of Three Species of Cockroaches to the Entomopathogenic Fungi Metarhizium anisopliae (Ascomycota, Hypocreales)","resumen":"Differences in free fatty acids (FFAs) chemical composition of insects may be responsible  for susceptibility or resistance to fungal infection. Determination of FFAs found in cuticular lipids can  effectively contribute to the knowledge concerning insect defense mechanisms. In this study, we have  evaluated the susceptibility of three species of cockroaches to the entomopathogenic fungi Metarhizium  anisopliae (Metschnikoff) Sorokin by topical application. Mortality due to M. anisopliae was highly significant  on adults and nymphs of Blattella germanica L. (Blattodea: Blattellidae). However, mortality was  faster in adults than in nymphs. Adults of Blatta orientalis L. (Blattodea: Blattidae) were not susceptible  to the fungus, and nymphs of Blaptica dubia Serville (Blattodea: Blaberidae) were more susceptible to  the fungus than adults. The composition of cuticular FFAs in the three species of cockroaches was also  studied. The analysis indicated that all of the fatty acids were mostly straight-chain, long-chain, saturated  or unsaturated. Cuticular lipids of three species of cockroaches contained 19 FFAs, ranging from C14:0 to  C24:0. The predominant fatty acids found in the three studied species of cockroaches were oleic, linoleic,  palmitic, and stearic acid. Only in adults of Bl. orientalis, myristoleic acid, c-linolenic acid, arachidic acid,  dihomolinoleic acid, and behenic acid were identified. Lignoceric acid was detected only in nymphs of  Bl. orientalis. Heneicosylic acid and docosahexaenoic acid were identified in adults of Ba. dubia.","palabras_clave":"fatty acid|cuticle|cockroach|entomopathogenic fungi|Metarhizium anisopliae"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17609,"idioma_id":4,"titulo":"Assessing the use of forest islands by parrot species in a neotropical savanna","resumen":"Understanding the effect of habitat fragmentation is a fundamental yet complicated aim of many ecological studies. Beni savanna is a naturally fragmented forest habitat, where forest islands exhibit variation in resources and threats. To understand how the availability of resources and threats affect the use of forest islands by parrots, we applied occupancy modeling to quantify use and detection probabilities for 12 parrot species on 60 forest islands. The presence of urucuri (Attalea phalerata) and macaw (Acrocomia aculeata) palms, the number of tree cavities on the islands, and the presence of selective logging,and fire were included as covariates associated with availability of resources and threats. The model-selection analysis indicated that both resources and threats variables explained the use of forest islands by parrots. For most species, the best models confirmed predictions. The number of cavities was positively associated with use of forest islands by 11 species. The area of the island and the presence of macaw palm showed a positive association with the probability of use by seven and five species, respectively, while selective logging and fire showed a negative association with five and six species, respectively. The Blue-throated Macaw (Ara glaucogularis), the critically endangered parrot species endemic to our study area, was the only species that showed a negative association with both threats. Monitoring continues to be essential to evaluate conservation and management actions of parrot populations. Understanding of how species are using this natural fragmented habitat will help determine which fragments should be preserved and which conservation actions are needed.","palabras_clave":"BOLIVIA|HABITAT|MACAW|OCCUPANCY MODELS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17610,"idioma_id":4,"titulo":"Oil extraction kinetics of hydrothermally pretreated Canola seeds","resumen":"In this work the kinetics of oil extraction from spring canola seeds subjected to a hydrothermal pretreatment with direct steam (393 K, 5 min) was studied. The differences between the seed internal structure generated by the application of this pretreatment and that of the untreated sample (ground sample) were observed by scanning electron microscopy. Oil from both samples was extracted with hexane at different times and temperatures using a stirred batch system. Oil yield increased up to 46%due to the hydrothermal treatment. A model was proposed to explain the oil extraction process from hydrothermally pretreated and untreated canola seeds, taking into account two main mechanisms: a washing process of the surface oil from the seed, and a diffusion process. Parameters of the model were fitted, and values of the oil fraction extracted during the washing step (0.27 and 0.50 for untreated and hydrothermally treated canola seeds, respectively) and the effective diffusion coefficient (3.1?9.4.10-12m2s-1) were obtained. The latter value showed an Arrhenius-type temperature dependence in the untreated sample, but the diffusion coefficient did not vary with temperature when oil diffusion was analyzed using hydrothermally pretreated seeds.","palabras_clave":"CANOLA|OIL EXTRACTION|KINETICS|HYDROTHERMAL PRETREATMENTS|SEM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17611,"idioma_id":4,"titulo":"ASSESMENT OF THE PRESENCE OF TOXOCARA EGGS IN SOILS OF AN ARID AREA IN CENTRAL-WESTERN ARGENTINA","resumen":"With the aim of studying the contamination of soils with eggs ofToxocara spp. in an arid area in the central-western region ofArgentina, 76 soil samples were collected from 18 towns belonging to six provinces ofcentral-western Argentina. They were processed by the centrifugal flotation method.No eggs of Toxocara spp. were found. It can be concluded that thenegative results are directly related to the characteristics of the environment andclimate present in the studied area. The finding of eggs in soils depends on severalfactors: the presence of canine or feline feces, the hygienic behavior of pet owners,the presence of stray animals without veterinary supervision, the weather andenvironmental conditions, and laboratory techniques used; and all these circumstancesmust be considered when comparing the results found in different geographicalregions. In order to accurately define the importance of public spaces in thetransmission of infection to humans, it is important to consider the role ofbackyards or green spaces around housing in small towns, where the population is notused to walking pets in public spaces, and in such cases a significant fraction ofthe population may acquire the infection within households.","palabras_clave":"TOXOCARIASIS|SOIL CONTAMINATION|ZOONOTIC|ENVIRONMENT|LABORATORY METHOD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17612,"idioma_id":4,"titulo":"Nanoribbons with semicrystalline core dispersed in a visible-light photopolymerized epoxy network","resumen":"It has been well documented that self-assembly of block copolymers (BCP) in selective solvents, where the core-forming block is a crystallizable polymer, results in micelle structures with exceptional aggregation morphologies determined mainly by the crystallization energy from the core. In this contribution, we apply this concept to create ribbon-like nanostructures dispersed in an epoxy network. The selected system was a polyethylene-b-poly(ethylene oxide) (PE-b-PEO) diblock copolymer in an epoxy monomer based on diglycidyl ether of bisphenol A (DGEBA). This system was selected on the bases that PEO is an epoxy-philic block which is completely miscible with DGEBA before and after curing reaction whereas PE is a crystallizable epoxy-phobic block. Under these conditions, we access to self-assembled nanostructures with semicrystalline core before curing reaction. With the aim of preserving the structural features of these micelles, the epoxy monomers were cured at room temperature (i.e., below the melting transition of the core-forming PE block) by photoinitiated cationic ring-opening polymerization. Long nanoribbons dispersed in the cured epoxy matrix were obtained, as characterized by SAXS patterns and TEM images. These ribbon-like micelles present a tendency to aggregate resulting in the formation of  face-to-face stacking of parallel micelles. We demonstrated that while the stacking number decreases with decreasing BCP concentration, the arrangement of the nanoribbons within one stack becomes less organized.","palabras_clave":"block-copolymer|epoxy|self-assembly"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17613,"idioma_id":4,"titulo":"An Immune Algorithm with Power Redistribution for Solving Economic Dispatch Problems","resumen":"In this paper, we present an algorithm inspired on the T-Cell model of the immune system (i.e., an artificial immune system), which is used to solve economic dispatch problems. The proposed approach is called IA_EDP, which stands for Immune Algorithm for Economic Dispatch Problem, and it uses two versions of a redistribution power operator which tries to keep feasible the solutions that it finds. The proposed approach is validated using eight problems taken from the specialized literature. Our results are compared with respect to those obtained by several other approaches. We also perform some statistical analysis in order to determine the sensitivity of our proposed approach to its parameters.","palabras_clave":"ARTIFICIAL IMMUNE  SYSTEM|ECONOMIC DISPATH PROBLEM|METAHEURISTIC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17614,"idioma_id":4,"titulo":"Kerr geometry in f(T) gravity","resumen":"  Null tetrads are shown to be a valuable tool in teleparallel theories of modified gravity. We use them to prove thatKerr geometry remains a solution for awide family of f(T) theories of gravity.  ","palabras_clave":"MODIFIED GRAVITY|TELLEPARALELISM|KERR GEOMETRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17615,"idioma_id":4,"titulo":"Surface relief gratings inscription in linear and crosslinked azo modified epoxy-isocyanate polymers","resumen":"This work analyses the SRG forming ability of a linear and a crosslinked polymer, both based on the same azo chromophore (Disperse Red 19, DR19) and diisocyanate (4,4´-metilen-bis(ciclohexyl isocyanate), DI) with similar glass transition temperature values. The effect of the experimental and geometrical parameters (such as beams polarization direction and interference pattern spacing) on the surface modulation process was examined as well.  The absence of photodegradation or bleaching was corroborated by comparing Raman spectra inside and outside the SRG zone.  Being a very important subject matter, the influence of crosslinking on the inscription rates and thermal stability of SRGs was investigated. Crosslinked films with an interesting modulation and good grating stability, even at high temperatures (160 °C), were obtained. Gratings shape was retained, and significant diffraction was still observed even well above the Tg of the bulk sample.","palabras_clave":"EPOXY ISOCYANATE POLYMER|AZOBENZENE|SURFACE RELIEF GRATING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17616,"idioma_id":5,"titulo":"Caracterización de los artefactos líticos del sitio Campo de Carrizal (depto. de Belén, Catamarca) correspondientes al período de Desarrollos Regionales\/Inka","resumen":"El sitio Campo de Carrizal (valle de Hualfín, Catamarca) consta de varios recintos y estructuras vinculadas con andenes de cultivo y a sistemas de irrigación correspondientes al Período de Desarrollos Regionales\/Inka. En este trabajo se presentan los resultados del estudio tecno-tipológico de los artefactos líticos tallados, pulidos y de molienda recuperados en el sitio. Entre los primeros observamos el uso de materias primas locales (rocas sedimentarias, volcánicas y minerales) y no locales (rocas volcánicas), apreciándose un tratamiento diferencial de las mismas. La obsidiana, intensamente aprovechada, está vinculada con la manufactura de puntas de proyectil. Los únicos dos artefactos pulidos corresponden a una cuenta de malaquita (recurso no local) y a un artefacto formatizado no diferenciado sobre pizarra (recurso local). Por último, entre los artefactos de molienda se registra el empleo únicamente de recursos locales y muy inmediatos, feldarenita para manos y granito para morteros.","palabras_clave":"ARTEFACTOS LÍTICOS|PERÍODO DE DESARROLLOS REGIONALES\/INKA|CATAMARCA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17617,"idioma_id":5,"titulo":"Calibración de modelo hidromecánico en mezclas de loess y bentonita","resumen":"Los suelos loessicos de la Ciudad de Córdoba, constituyen uno de los materiales más importantes empleados en obras de ingeniería especialmente en obras viales. Se han realizado importantes estudios investigando sus propiedades geotécnicas. En este trabajo, se realizaron ensayos de compresión no confinada y ensayos de infiltración mediante el empleo de un permeámetro a pared flexible. Se realizaron mezclas de suelo loessico con adición de bentonita en distintos porcentajes. Se evaluó el contenido de humedad, peso unitario seco y contenido de bentonita en las muestras remoldeadas. Se compararon los resultados obtenidos experimentalmente con los modelos propuestos mediante formulaciones matemáticas.    Los resultados muestran que es posible lograr una aproximación entre el comportamiento hidromecánico teórico obtenido mediante la modelación y calibración de funciones racionales  respecto del comportamiento empírico obtenido como resultado de ensayos en mezclas de suelo loessico estabilizadas con bentonita.","palabras_clave":"BENTONITA|LOESS|PERMEAMETRO|MODELO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17618,"idioma_id":4,"titulo":"Identification of genes induced by \/Fusarium graminearum\/ inoculation in the resistant durum wheat line Langdon(Dic-3A)10 and the susceptible parental line Langdon","resumen":"The wheat recombinant chromosome inbred line LDN(Dic-3A)10, obtained through introgression of a T. dicoccoides disomic chromosome 3A fragment into T. turgidum spp. durum var. Langdon, is resistant to fusarium head blight (FHB) caused by Fusarium graminearum. To identify genes involved in FHB resistance, we used a cDNA-AFLP approach to compare gene expression between LDN(Dic-3A)10 and the susceptible parental line LDN at different time points postinoculation. In total, 85 out of the ~500 transcript-derived fragments (TDFs) were found to be differentially expressed: 36% and 19% were upregulated in LDN(Dic-3A)10 and LDN, respectively, whereas 45% were induced in both genotypes. Several of the cloned TDFs showed similarity to proteins involved in specific recognition of plant pathogens or associated with early responses to infection. However, there was a group of TDFs that, in spite of being specific to the inoculation response did not show similarity to characterized proteins. The availability of T. aestivum genome sequences allowed in silico mapping of 28 TDFs and the identification of several genes and regulatory regions. Analysis of promoter regions revealed the potential existence of shared transcription regulation mechanisms. For instance, a number of TDF-associated genes contained binding sites for WRKY transcription factors, which have been implicated in the regulation of genes associated with pathogen defense. Collectively, our results revealed specific pathogen recognition in the interactions of LDN and LDN(Dic-3A)10 with F. graminearum at the time that demonstrated changes in the expression of several transcripts attributable to the presence of the QTL Qfhs.ndsu-3AS.","palabras_clave":"FUSARIUM GRAMINEARUM|DURUM WHEAT|RESISTANCE|CDNA-AFLP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17619,"idioma_id":4,"titulo":"Experimental and numerical analysis to collapse of a framed structure subjected to seismic loading","resumen":"The nonlinear numerical analysis to collapse of civil structures presents several difficulties, even for mechanically well-characterized materials, such as steel. In the case of steel, where the nonlinear constitutive equation is one of the simplest and best known, in many cases there are large differences when the numerical analysis and experimental results are compared. In this paper, the results of an experimental and numerical analysis of a single degree of freedom (SDOF) steel structure are presented. The structure was subjected to near fault earthquakes that caused nonlinear behavior of their components and structural collapse. The experimental model was tested on a shaking table. Complementary tests were performed to characterize the properties of the steel employed, and thus define the parameters used in the numerical simulation. After the calibration of the nonlinear material model, a comparison is made between the experimental and numerical results obtained. Finally, a numerical study, following the modeling methodology obtained from the numerical?experimental analysis, is performed to quantify the influence of the P-Delta effect on the structural collapse.","palabras_clave":"Nonlinear dynamic analysis|Collapse|Experimental test|Shaking table"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17620,"idioma_id":4,"titulo":"Study of the distribution of Elphidium aff poeyanum (D?Orbigny) and Buccella peruviana (D?Orbigny) from the Colorado basin (South America): Holocene paleoenvironmental inferences.","resumen":"Benthic foraminiferal assemblages recovered from T1 core samples of the Colorado basin, in the continental margin of southeastern Argentina, were analyzed to understand their distribution patterns and ecological preferences. The foraminiferal assemblages showed two well-represented species: Elphidium aff. poeyanum (d´Orbigny) and Buccella peruviana (d´Orbigny), among others of very low proportion. Statistical analyses allowed identifying positive correlations between the abundance of E. aff. poeyanum and silt content and between B. peruviana and the sand content,  reflecting better conditions for the development of both species. From a paleoenvironmental point of view, the assemblages recorded is characteristic of an inner shelf, showing a passage from typical shallow waters to normal marine conditions, such passage represents a rise in the sea level during the post-last glacial maximum transgression. The results obtained contribute to the knowledge of South American foraminifers and paleoenvironments during the Holocene.","palabras_clave":"ELPHIDIUM AFF. POEYANUM|BUCCELLA PERUVIANA|PALEOENVIRONMENTAL CHANGE|SEA LEVEL CHANGES, HOLOCENE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17621,"idioma_id":4,"titulo":"In situ conservation of wild potato germplasm in Argentina: Example and possibilities","resumen":"The potato is the third most important food crop worldwide and in situ conservation ofits wild relatives is considered an urgent priority. Although regions of the Americas withhigh wild potato species richness have been identified, the need to identify specific sitesfor establishing genetic reserves is still pending. Matching distribution data of Argentineanwild potato species to existing protected areas (PA), two priority sites were identified.The creation of genetic reserves in these two PA would make possible to preserve populationsof species that have been successfully incorporated into the crop and are listed inthe global priority Crop Wild Relative inventory. While the presence of target species inPA could ensure a passive conservation, in situ conservation programs require to activelyintervene in selected areas. From a field study performed on populations of the wild potatoSolanum kurtzianum naturally growing in a PA, the Villavicencio Natural Reserve (Mendozaprovince), a baseline with distribution, biotic interactions, sprouting behavior, populationdynamics, AFLP and pollen viability data was established. Based on a systematic work inthis Reserve we have generated a working protocol to be implemented at national and regionallevels for the in situ conservation of potato wild relatives.","palabras_clave":"Solanum|Crop Wild Relatives|Management Plan|Protected areas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17622,"idioma_id":4,"titulo":"NEW ENZYMATIC PATHWAYS FOR THE REDUCTION OF REACTIVE OXYGEN SPECIES IN Entamoeba histolytica","resumen":"Background  Entamoeba histolytica, an intestinal parasite that is the causative agent of amoebiasis, is exposed to elevated amounts of highly toxic reactive oxygen and nitrogen species during tissue invasion. A flavodiiron protein and a rubrerythrin have been characterized in this human pathogen, although their physiological reductants have not been identified.  Methods  The present work deals with biochemical studies performed to reach a better understanding of the kinetic and structural properties of rubredoxin reductase and two ferredoxins from E. histolytica.  Results  We complemented the characterization of two different metabolic pathways for O2 and H2O2 detoxification in E. histolytica. We characterized a novel amoebic protein with rubredoxin reductase activity that is able to catalyze the NAD(P)H-dependent reduction of heterologous rubredoxins, amoebic rubrerythrin and flavodiiron protein but not ferredoxins. In addition, the protein exhibited NAD(P)H oxidase activity, which generates hydrogen peroxide from molecular oxygen. We describe how different ferredoxins were also efficient reducing substrates for both flavodiiron protein and rubrerythrin.  Conclusions and General Significance  The enzymatic systems herein characterized could contribute to the in vivo detoxification of O2 and H2O2, playing a key role for the parasite defense against reactive oxidant species. To the best of our knowledge this is the first characterization of a eukaryotic rubredoxin reductase, including a novel kinetic study on ferredoxin-dependent reduction of flavodiiron and rubrerythrin proteins.","palabras_clave":"E. HISTOLYTICA|REACTIVE SPECIES|DETOXIFICATION|PATHWAYS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17623,"idioma_id":4,"titulo":"Catalytic removal of a mixture of volatile organic compounds present in indoor air at various work sites over Pt, MnOx and Pt\/ MnOx supported monoliths","resumen":"The elimination of volatile organic compounds (VOCs) was investigated placing a novel catalytic system in the chimney venting of a commercial air extractor, using Pt, Mn and Pt\/Mn catalysts supported on ceramic monoliths. The VOCs oxidized were chloroform (CHCl3), methyl ethyl ketone (MEK), toluene and xylene, alone, in a binary mixture and in a mixture of all of them. The conversion of VOCs is in general similar, regardless of whether they are in a mixture or alone. Pt\/Mn monoliths exhibited the highest destruction activity for the abatement of VOCs alone and in mixtures, due to a synergetic effect between platinum and manganese. The results show that these catalytic systems can be coupled satisfactorily in the venting of the air extraction equipment still working at high flow rates.","palabras_clave":"Eliminación de COVs|Catálisis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17624,"idioma_id":4,"titulo":"Phages of dairy Leuconostoc mesenteroides: genomics and factors influencing their adsorption","resumen":"Phages infecting Leuconostoc mesenteroides strains can be overlooked during milkfermentation because they do not slowdown the acidification process. However, they can negatively impact the flavor profile of the final product. Yet, the information about these phages is still scarce. In this work, we investigated diverse factors influencing the adsorption of seven virulent Ln. mesenteroides phages, isolated from blue cheese manufacture in Argentina, to their host cells. The addition of calcium ions was generally necessary to observe complete cell lysis and plaque formation for four of the seven phages, but adsorption was very high even in the absence of this cation for all phages. The temperature barely influenced the adsorption process as it was high within the temperature range tested (0 to 50°C). Moreover, the kinetics of adsorption were similar on viable and non-viable cells, revealing that phage adsorption does not depend on physiological state of the bacterial cells. The adsorption rates were also high at pH values from 4 to 9 for all Ln. mesenteroides phages. We also analyzed the complete genome sequences of two of these phages. Complete nucleotide analysis of phages Ln-8 and Ln-9 showed dsDNA genomes with sizes of 28.5 and 28.9 kb, and the presence of 45 and 48 open reading frames (ORFs), respectively. These genomes were highly similar to those of previously characterized &#934;1-A4 (USA, sauerkraut, fermentation) and &#934;LN25 (England, whey), both virulent Ln. mesenteroides phages. A detailed understanding of these phages will lead to better control strategies.","palabras_clave":"LEUCONOSTOC|PHAGE INFECTION|ADSORPTION|SEQUENCE ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17625,"idioma_id":5,"titulo":"Metabolitos de bacterias lácticas antagónicos al crecimiento de microorganismos cariogénicos","resumen":"El objetivo de este trabajo fue aislar, purificar y conservar cepas de Streptococcus spp. y Lactobacillus spp. de la cavidad bucal, y enfrentarlos ?in vitro? a bacterias lácticas.  Se seleccionaron individuos con caries activas y se recolectaron muestras de saliva. Para recuperar Streptococcus spp., se empleó medio Mitis Salivarius (Difco, Detroit, MI, Estados Unidos) y para Lactobacillus spp. se usó Rogosa (Biokar Diagnostics, Beauvais, Francia). Como cepas productoras de bacteriocinas, se utilizaron siete cepas de Lactococcus lactis subsp. lactis, dos de Leuconostoc mesenteroides y una de Lactococcus lactis. La actividad antagónica de las bacterias lácticas al crecimiento 'in vitro' de bacterias cariogénicas se determinó con el método de difusión en agar.   El desarrollo y la multiplicación de las cepas de Streptococcus spp. de origen bucal ensayadas se vieron afectados por la presencia de metabolitos generados por las cepas de Lactococcus lactis subsp. Lactis","palabras_clave":"LACTOCOCCUS LACTIS SUBSP LACTIS|MICROORGANISMOS CARIOGÉNICOS|METABOLITOS ANTAGÓNICOS|BACTERIAS LÁCTICAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17626,"idioma_id":5,"titulo":"La circulación del conocimiento entre procesos de lectura y escritura","resumen":"El presente trabajo se estructura en torno a un Proyecto de Innovación e Investigación para el mejoramiento de la Enseñanza de Grado (PIIMEG) presentado en la convocatoria del año 2013. Estos proyectos son impulsados por la Secretaría Académica de la Universidad Nacional de Río Cuarto (UNRC) y subsidiados por la Secretaría de Ciencia y Técnica de dicha Universidad con la finalidad de promover innovaciones pedagógicas entre los equipos docentes  de asignaturas de un mismo año o entre asignaturas de diferentes años de la carrera. El objetivo del proyecto que se presenta en este artículo es facilitar el acceso de los ingresantes a la cultura académica de las disciplinas específicas de la carrera elegida -sus formas de razonar, construir, validar y comunicar el conocimiento- como a la cultura institucional de la universidad -el conocimiento de sus códigos, prácticas, valores, formas de participaciónen  tanto espacios a habitar a través del aprendizaje de nuevos oficios.  Este proyecto se constituye también en una experiencia de acompañamiento pedagógico a los equipos docentes de los primeros años, ya que intenta ofrecerles espacios de asesoramiento psicopedagógico con la finalidad de revisar la oferta pedagógico-didáctica que se diseña para primer año y comenzar a pensar las asignaturas no solo como campos conceptuales sino también, como campos retóricos y discursivos. La experiencia de trabajo que se desarrolla en este escrito se llevó a cabo en los módulos de Biología, Introducción a las Ciencias Morfológicas y Los estudiantes y las tutorías para las carreras de Ingeniería Agronómica y Medicina Veterinaria pertenecientes a la Facultad de Agronomía y Veterinaria (FAV) de la Universidad Nacional de Río Cuarto (UNRC). Esta práctica se circunscribe en los Encuentros de Integración Universitaria (EIU) que se desarrollan durante el periodo de ingreso previo al inicio del primer cuatrimestre de primer año. El artículo presenta en la primera parte el problema que origina la innovación, luego se ofrece la fundamentación conceptual apelando a las razones de índole institucional y académica que justifican dicha innovación. En el apartado siguiente se detallan los objetivos que persigue el proyecto con docentes y alumnos y luego se describe la innovación tanto la que se vincula con la formación docente como las propuestas pedagógicas destinadas a los alumnos que han sido desarrolladas en los módulos de los EIU, por último se exponen algunas consideraciones finales.","palabras_clave":"INNOVACIÓN|INGRESO|PIIMEG"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17627,"idioma_id":4,"titulo":"Isotropic exchange interaction between Mo and the proximal FeS center in the xanthine oxidase family member aldehyde oxidoreductase from Desulfovibrio gigas on native and polyalcohol inhibited samples: an EPR  and QM\/MM study","resumen":"p { margin-bottom: 0.08in; }                              Aldehyde  oxidoreductase from Desulfovibrio gigas (DgAOR) is a  homodimeric molybdenum-containing protein that catalyzes the  oxidative hydroxylation of aldehydes to carboxylic acids and contains  two major domains called Mo and FeS domains, the latter containing  two [2Fe-2S] centers called FeS 1 and FeS 2. The electron transfer  reaction inside DgAOR is proposed to be performed through a  chemical pathway linking Mo and the two FeS clusters. The proposed  electron transfer pathway between Mo and FeS 1 is formed by the Mo  pyranopterin ligand and the gamma sulfur atom from Cys 139  coordinated to the nearest iron atom of FeS 1. EPR studies performed  on reduced as-prepared DgAOR showed that this pathway is able  to transmit very weak exchange interactions between Mo(V) and reduced  FeS 1. Similar EPR studies but performed on DgAOR samples  inhibited with glycerol and ethylene glycol showed that the value of  the exchange coupling constant J increases ~2 times upon  alcohol inhibition. Structural studies in these DgAOR samples  have demonstrated that the Mo-FeS 1 bridging pathway does not show  significant differences, confirming that the changes in J  observed upon inhibition cannot be ascribed to structural changes  associated neither with pyranopterin and FeS 1 nor with changes in  the electronic structure of FeS 1, as its EPR properties remain  unchanged. Theoretical calculations  indicate that the changes in J  detected by EPR are related to changes in the electronic structure of  Mo(V) determined by the replacement of the OHx labile ligand for an  alcohol molecule. Since  the relationship between electron transfer rate and isotropic  exchange interaction, the present results suggest that the  intraenzyme electron transfer process mediated by the pyranopterin  moiety is governed by a Mo ligand-based regulatory mechanism.>I am pleased to inform you that your revised   >manuscript, 'Isotropic exchange interaction   >between Mo and the proximal FeS center in the   >xanthine oxidase family member aldehyde   >oxidoreductase from Desulfovibrio gigas on   >native and polyalcohol inhibited samples: an EPR   >and QM\/MM study' (JBIC-14-07-00105.R1) has been   >accepted for publication. Thus I am forwarding   >your materials to the publisher.  Please note   >that if you have not yet uploaded a main text   >.rtf or .doc file into the Manuscript Central   >web-based system, you will need provide such a   >file immediately. Supplementary Material files,   >on the other hand, must be in .pdf format.   >Please attach any such necessary files to an email addressed to  >jbic@umn.edu  >in order for the publisher to process your   >manuscript. If you have any questions about the   >size of your file or how best to attach it,   >contact our editorial assistant at this address right away.  >  >I appreciate your support of JBIC.  >  >Sincerely,  >  >Dr. Paul Bernhardt  ","palabras_clave":"ALDEHYDE OXIDOREDUCTASE|MOLYBDENUM|EXCHANGE INTERACTION|EPR|QM\/MM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17628,"idioma_id":5,"titulo":"Experiencias en I+ D orientadas al desarrollo de productos tecnológicos como aporte a la administración en salud mediada por TIC","resumen":"Se sintetizan experiencias en la producción de software en el marco de un proyecto de I+D considerados como emprendimientos tecnológicos. Estos productos software de las TIC para apoyar a la administración en salud han sido desarrollados aplicando métodos y herramientas de la Ingeniería del Software y para fortalecer la formación de recursos humanos desde ámbitos de la Universidad.","palabras_clave":"PROTOTIPOS DE SISTEMAS INFORMÁTICOS|SOLUCIONES WEB|EMPRENDIMIENTOS|I+D|EDUCACIÓN SUPERIOR|EXPERIENCIAS EN EL MEDIO LOCAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17630,"idioma_id":5,"titulo":"La enseñanza de la metodología de la investigación en la formación de grado: experiencias en Trabajo Social","resumen":"    El trabajo aborda la problemática y desafíos de la enseñanza  de la metodología de la investigación en Ciencias Sociales en el contexto de la  formación de grado en Argentina y atendiendo a la especificidad que da su  inserción en carreras de Trabajo Social. Se presenta una estrategia pedagógico-  didáctica en la que se intenta: 1- enlazar la reflexión teórica epistemológica  con la capacitación para la producción de conocimientos y la adquisición de  práctica en técnicas de trabajo de campo fundamentalmente cualitativas:  observación y entrevistas de corte sociológico; 2- trabajar la tensión entre la  producción de conocimientos y la intervención profesional, ante lo cual se  plantea la necesidad de un cambio conceptual para llevarla adelante,  manteniendo la identidad de cada una y estableciendo una lógica de interacción  entre ambas. La estrategia pedagógica-didáctica se presenta primero en sus aspectos  conceptuales y luego se ilustra con una experiencia de producción de  conocimientos sobre un tema referido a la salud reproductiva: la prevención del  cáncer cérvico uterino, en dos universidades nacionales, UNL y UNR. El trabajo  cierra con una evaluación crítica de la estrategia desarrollada.  ","palabras_clave":"ENSEÑAR A INVESTIGAR|ESTRATEGIA PEDAGOGICO DIDACTICA|INTERVENCION|TRABAJO SOCIAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17631,"idioma_id":5,"titulo":"LAS POLÍTICAS DE PROMOCIÓN DE LAS EXPORTACIONES EN LA PROVINCIA DE SANTA FE, PERÍODO 2008-2011. ENTRE AVANCES INSTITUCIONALES INNOVADORES Y RESULTADOS LIMITADOS","resumen":"El artículo analiza las políticas de promoción de las exportaciones implementadas por el gobierno del Frente Progresista, Cívico y Social en la Provincia de Santa Fe, durante el período 2008-2011. Para llevar a cabo el estudio fue preciso construir una base de datos propia tomando como unidad de análisis las empresas beneficiarias. A partir de esta nueva información se realizó un análisis descriptivo por: Nodos regionales, Sistemas productivos, Nivel de participación en los eventos, Nivel de internacionalización alcanzado. Se observa que los resultados obtenidos por las políticas implementadas son limitados y existen campos de acción considerables a atender en el futuro. Tal situación plantea la necesidad de que las políticas promoción de las exportaciones realicen un proceso de maduración si es que pretenden responder eficazmente a las demandas que le presenta la compleja realidad empresarial.","palabras_clave":"SANTA FE |POLITICAS PUBLICAS|PROMOCION DE EXPORTACIONES|EMPRESAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17632,"idioma_id":4,"titulo":"Bone  augmentation in rabbit tibia using microfixed cobalt-chromium membranes with whole blood, tricalcium phosphate  and bone marrow cells.","resumen":"Abstract: To assess bone augmentation based on a non-critical defect, 1.5 mm deep cobalt-chromium (Co-Cr) bar- rier membranes were placed on seven adult California rabbits with three different grafting situations: whole blood, whole blood with tricalcium phosphate (TCP), and TCP mixed with bone marrow cells. Macroscopic assessment of the animals was performed once a week and densitometric studies were performed once a month. Three months post-surgery, after detaching the membranes, tibias were sectioned and followed the routine laboratory process- ing for decalcified sections, with inclusion in paraffin and staining by hematoxylin and eosin technique. Bone aug- mentation was observed for each animal, even sometimes over the Co-Cr membranes. Compact bone was mostly observed for every situation, with a higher cellular activity on those samples with bone grafts. This could be due to the presence of graft remains at the growth area. It could be concluded that blood supply to the site providing growth factors by the blood clot formation, and the placement of an osteoconductive non-resolvable membrane that favors osseoinduction, may be sufficient elements to achieve bone augmentation in a period of three months in rabbit tibia.","palabras_clave":"Bone augmentation|cobalt-chromium|bone marrow cells|tricalcium phosphate"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17633,"idioma_id":4,"titulo":"Sodium-reduced lean sausages with fish oil optimized by a mixture design approach","resumen":"A partial NaCl replacement by KCl and sodium tripolyphosphate on low-fat meat sausages formulated with fish  oil was studied using a mixture design. Thermal behavior by modulated differential scanning calorimetry, physicochemical,  and textural propertieswere determined; afterwards they were mathematically modeled as a function  of salts content. The thermo-rheological behavior of the different formulationswas also studied in a controlstress  rheometer. The optimal sodium reduction was found employing a desirability function approach. This  formulation was experimentally validated and employed for microstructure analysis by environmental scanning  microscopy. The results obtained in this work revealed that partial sodium replacement affected the matrix microstructure,  but this change had no impact on sensory acceptability. In comparison with US and Argentinean  commercial sausages, our product has 58% and 70% less Na+ respectively","palabras_clave":"LOW-FAT|MEAT EMULSION|LOW-SODIUM|POTASSIUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17634,"idioma_id":4,"titulo":"Chemical composition and nutritional value of Argentine commercial edible mushrooms","resumen":"The chemical composition and nutritional value of four edible mushroom varieties  (Champignons, Portobellos, Girgolas and Shiitakes) commonly cultivated and  consumed in Argentina was determined. Chemical composition includes water content,  crude protein, lipids, ash, carbohydrates, mineral composition and bioactive  components (dietary fiber, chitin content and phenolic compounds). Results show that  edible mushrooms are rich sources of water and carbohydrates and have low amounts  of lipids. Also, they are rich in potassium and phosphorus whereas have a low content  of sodium. The composition of bioactive components reveals that mushrooms are rich  in fiber and have an interesting amount of total phenolic compounds that could assure  an antioxidant capacity. Chitin content is an important part of total fiber and in this work  a new method for chitin isolation is proposed. Multivariate analysis (Principal  Component Analysis) was applied to discriminate among the different mushrooms  varieties and to establish relationships among samples and nutritional parameters.","palabras_clave":"ARGENTINE MUSHROOMS|NUTRITIONAL VALUE|FOOD COMPOSITION|CHITIN EXTRACTION|MULTIVARIATE ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17635,"idioma_id":4,"titulo":"Random walk model to study cycles emerging from the exploration-exploitation trade-off","resumen":"We present a model for a random walk with memory, phenomenologically inspired in a biological system. The walker has the capacity to remember the time of the last visit to each site and the step taken from there. This memory affects the behavior of the walker each time it reaches an already visited site modulating the probability of repeating previous moves. This probability increases with the time elapsed from the last visit. A biological analog of the walker is a frugivore, with the lattice sites representing plants. The memory effect can be associated with the time needed by plants to recover its fruit load. We propose two different strategies, conservative and explorative, as well as intermediate cases, leading to nonintuitive interesting results, such as the emergence of cycles.","palabras_clave":"Random Walk|Memory|Patterns"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17636,"idioma_id":4,"titulo":"Exchange-coupling in thermal annealed bimagnetic core\/shell nanoparticles","resumen":"In this study we demonstrate that the effective coupling of the magnetic phases in core\/shell nanoparticles can be promoted by an appropriate thermal annealing. In this way, the magnetization thermal stability of the hard ferrimagnetic CoFe2O4 oxide can be increased up to room temperature when coupled to a CoO antiferromagnetic core in an inverse core\/shell structure. In addition, the results show that, being encapsulated in a &#8764;2 nm thick CoFe2O4 shell, the CoO core is successfully protected against oxidation which is crucial for the effectiveness of the magnetic coupling at the interface.","palabras_clave":"Nanostructured materials|Chemical Synthesis|Magnetization|Coreshell nanoparticles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17637,"idioma_id":4,"titulo":"Epigenetic variations in breast cancer progression to lymph node metastasis","resumen":"Breast cancer is a heterogeneous disease characterized by the accumulation of genetic and epigenetic alterations that contribute to the development of regional and distant metastases. Lymph node metastasis (LNM) status is the single most important prognostic factor. Metastatic cancer cells share common molecular alterations with those of the primary tumor, but in addition, they develop distinct changes that allow the cancer to progress. There is an urgent need for molecular studies which focus on identifying genomic and epigenomic markers that can predict the progression to metastasis. The objective of this study was to identify epigenetic similarities and differences between paired primary breast tumor (PBT) and LNM. We employed Methylation-Specific-MLPA (Multiplex ligation-dependent probe amplification) to assess the methylation status of 33 cancer-related genes in a cohort of 50 paired PBT and LNM specimens. We found that the methylation index, which represents the degree of aberrantly methylated genes in a specimen, was maintained during the progression to LNM. However, some genes presented differential methylation profiles. Interestingly, PAX6 presented a significant negative correlation between paired PBT and LNM (p = 0.03), which indicated a switch from methylated to unmethylated status in the progression from PBT to LNM. We further identified that the methylation status of PAX6 on the identified CpG site functionally affected the expression of PAX6 at the mRNA level. Our study unraveled significant epigenetic changes during the progression from PBT to LNM, which may contribute to improved prognosis, prediction and therapeutic management of metastatic breast cancer patients.","palabras_clave":"EPIGENETIC|BREAST CANCER|METASTASIS|PAX6"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17638,"idioma_id":4,"titulo":"Preparation and characterization of MOS capacitors for in situ measurement during radiation damage studies","resumen":"Space radiation environment is  composed by a variety of particles with energies ranging from keV to some GeV. These  particles are either trapped into the magnetic field of the Earth or are  passing through the Solar System. Some of the satellite electronics is based on  silicon devices which suffer degradation due to environmental radiation. To  study heavy ion and other particles effects we designed and fabricated MOS  (metal oxide semiconductor) ad hoc capacitors. Radiation damage test were made  using the Van de Graaf (TANDAR) heavy ion accelerator. In situ  characterization was performed by means of C-V (capacitance-voltage)  measurements during irradiation experiments and from the curves obtained the  characteristic parameters were estimated.","palabras_clave":"SEMICONDUCTOR|MOS DEVICE|RADIATION DAMAGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17639,"idioma_id":5,"titulo":"Relación tubo polínico\/pistilo en cruzamientos interespecificos en el género Nierembergia (Solanaceae)","resumen":"Se estudió la relación estigma-polen\/estilo-tubo polínico (EPETP) en cruzamientos interespecíficos recíprocos entre N. linariaefolia, N. ericoides, N. scoparia, N. aristata, N. veitichii, y N. calycina, con el objetivo de identificar cruzamientos compatibles para la obtención de híbridos como herramientas del mejoramiento. Para ello se colectaron pistilos 24 horas post-polinización (PP). Los materiales fueron observados con microscopía de fluorescencia utilizando azul de anilina como tinción. Para la evaluación del crecimiento de tubos polínicos en pistilos se consideró la distancia recorrida por los tubos y la cantidad de tubos en diferentes porciones del estilo. El estudio de EPETP permitió corroborar que la incompatibilidad en muchas de las especies pertenecientes al género Nierembergia se expresa en el estilo, inhibiendo el crecimiento del tubo polínico en diferentes niveles del mismo. Los cruzamientos N. scoparia x N. ericoides; N. aristata x N. veitichii, N. linariaefolia x N. scoparia, N. linariaefolia x N. ericoides y sus recíprocos fueron detectados como los putativos para la obtención de híbridos interespecíficos. Estos cruzamientos fueron los únicos donde se observaron tubos polínicos penetrando la micrópila de los óvulos.","palabras_clave":"MEJORAMIENTO|HYBRIDOS|RELACION ESTIGMA-POLEN|INCOMPATIBILIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17640,"idioma_id":4,"titulo":"Antimicrobial activity of essential oils of Thymus vulgaris and Origanum vulgare on phytopathogenic strains isolated from soybean","resumen":"The aim of this work was to study the antimicrobial activity of essential oils obtained from Thymus vulgaris (thyme) and Origanum vulgare (oregano) on phytopathogenic Pseudomonas species isolated from soybean. Strains with characteristics of P. syringae were isolated from leaves of soybean plants with blight symptoms. Ten of these could be identified in Group Ia of LOPAT as P. syringae. Six of these were confirmed as P. syringae using 16S rRNA, indicating the presence of these phytopathogenic bacteria in east and central Argentina. All the phytopathogenic bacteria were re-isolated and identified from the infected plants. MIC values for thyme were 11.5 and 5.7 mgml1 on P. syringae strains, while oregano showed variability in the inhibitory activity.  Both essential oils inhibited all P. syringae strains, with better inhibitory activity than the antibiotic streptomycin. The oils were not bactericidal for all pseudomonads. Both oils contained high carvacrol (29.5% and 19.7%, respectively) and low thymol (1.5%).  Natural products obtained from aromatic plants represent potential sources of molecules with biological activity that could be used as new alternatives for the treatment of phytopathogenic bacteria infections.","palabras_clave":"ANTIMICROBIAL ACTIVITY|ESSENTIAL OIL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17641,"idioma_id":4,"titulo":"Synthesis of novel thiazole-based 8,9-dihydro-7H-pyrimido[4,5-b] [1,4]diazepines as potential antitumor and antifungal agents","resumen":"AbstractA new series of novel thiazole-based 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines 6aeg and 7aegwere obtained with high regioselectivity from the reaction of triamino- or tetraaminopyrimidines 4 and5 with a,b-unsaturated carbonyl compounds 3aeg based on 2,4-dichlorothiazol-5-carbaldehyde 1.Twelve of the synthesized compounds were selected and tested by US National Cancer Institute (NCI) fortheir antitumor activity against 60 different human tumor cell lines. Compounds 7d and 7g showedimportant GI50 ranges of 1.28e2.98 mM and 0.35e2.78 mM respectively under in vitro assays. In addition,6aeg and 7aeg were tested for antifungal properties against the clinical important fungi Candida albicansand Cryptococcus neoformans. Although these compounds showed moderate activities againstC. albicans, the 2-amino derivatives 7aeg and mainly 7a and 7b, showed high activity against standardizedand clinical isolates of C. neoformans with MIC50 ¼ 7.8e31.2 mg\/mL, MIC80 ¼ 15.6e31.2 mg\/mLand MIC100 ¼ 15.6e62.5 mg\/mL. In addition, since both compounds were fungicide rather than fungistaticthese thiazole-based 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines appear as good candidates forfurther development not only as antifungal but also as antitumor drugs.","palabras_clave":"THIAZOLE|REGIOSELECTIVITY|PYRIMIDO[4,5-B][1,4]DIAZEPINES|ANTITUMOR ACTIVITY|ANTIFUNGAL ACTIVITY."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17642,"idioma_id":4,"titulo":"Chronic systemic IL-1beta; exacerbates central neuroinflammation independently of the blood-brain barrier integrity","resumen":"Peripheral circulating cytokines are involved in immune to brain communication and systemic inflammation is considered a risk factor for flaring up the symptoms in most neurodegenerative diseases. We induced both central iflammatory demyelinating lesion, and systemic iflammation with an interleukin-1b expressing adenovector.  The peripheral pro-inflammatory stimulus aggravated the ongoing central lesion independently of the blood brain barrier (BBB) integrity. This model allows studying the role of specfic molecules and cells (neutrophils) from the innate immune system, in the relationship between central and peripheral communication, and on relapsing episodes of demyelinating lesions, along with the role of BBB integrity.","palabras_clave":"INTERLEUKIN-1|MULTIPLE SCLEROSIS|NEUROINFLAMMATION|NEUTROPHILS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17643,"idioma_id":4,"titulo":"Prenatal restraint stress decreases the expression of Alpha-7 Nicotinic receptor in the brain of adult rat offspring","resumen":"          Prenatal stress (PS) strongly impacts fetal  brain development and function in adulthood. In normal aging and Alzheimer`s  disease, there is hypothalamic-pituitary-adrenal axis dysfunction and loss of  cholinergic neurons and neuronal nicotinic acetylcholine receptors (nAChRs).&nbsp; This study investigated whether prenatal  restraint stress &nbsp;affects nAChR expression  in the brain of adult offspring. For PS, pregnant dams were placed in a plastic  restrainer for 45 minutes, three times daily during the last week of pregnancy;  controls were undisturbed. Male offspring were analyzed at postnatal day (PND) 60  (n=4 rats per group). Western blot (WB) and fluorescence microscopy showed that  PS decreased &#945;7-AChR subunit expression (~50%) in the frontal cortex in the  adult offspring. PS decreased significantly the number of &#945;7-AChR-expressing  cells in the medial prefrontal cortex (by ~25%) and in the sensory-motor cortex  (by ~20%) without affecting the total cell number in those areas. No  alterations were found in the hippocampus by quantitative  polymerase chain reaction (qPCR), or WB  analysis, but a detailed fluorescence microscopy analysis showed that PS affected  &#945;7-AChR mainly in the CA3 and dentate gyrus subfields: PS decreased &#945;7-AChR  subunit expression by ~25% and ~30%, respectively. Importantly, PS decreased  the number of &#945;7-AChR-expressing cells and the total cell number (by ~15% and 20%,  respectively) in the dentate gyrus. PS differently affected &#945;4-AChR: PS  impaired its mRNA expression in the frontal cortex (by ~50%), without affecting  protein levels. These results demonstrate that disturbances during  gestation produce long term alterations in the expression pattern of a7-AChR in rat brain.  ","palabras_clave":"AGING|CHOLINERGIC|CORTEX|GESTATIONAL STRESS|HIPPOCAMPUS|NEURODEGENERATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17644,"idioma_id":4,"titulo":"Novel nanoinsecticides based on essential oils to control the German cockroach","resumen":"The physicochemical characterization and residual insecticidal activity of poly(ethylene glycol) (PEG) nanoparticles containing essential oils (EOs) from geranium (Geranium sp.) and bergamot (Citrus reticulate L.) were evaluated against Blatella germanica for 1 year. The nanoparticles size increased during the storage time from 235 to 450 nm; the EO content decreased approximately 50 %, and the abundance of the major components did not show any differences between pre- and post-formulation. The surface characteristics of nanoparticles were analyzed by transmission electronic microscopy.  The EO nanoparticles produced a notable increase in the residual contact toxicity apparently because of the slow and persistent release of the active terpenes. In addition, the nanoformulation enhanced the EO contact toxicity. The results indicate that these novel systems could be developed as control agents against German cockroaches.","palabras_clave":"NANOPARTICLES|ESSENTIAL OILS|BLATELLA GERMANICA|RESIDUAL CONTACT TOXICITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17645,"idioma_id":5,"titulo":"Indicadores de consumo y gastos en salud para evaluación de gestión de obras sociales provinciales","resumen":"Las obras sociales provinciales ocupan un lugar preponderante en el sistema de financiación de salud argentino. Dada la complejidad del mercado donde actúan y la segmentación de este colectivo, se visibiliza la necesidad de contar con indicadores que posibiliten el control de gestión de variables claves del sector sanitario. En esta investigación, con una metodología cuantitativa, a partir de la implementación de encuestas se relevó información que permite exponer los resultados obtenidos en el indicador tasa de consulta por beneficiario para las organizaciones objeto de estudio, en el trienio 2011?2013. Cabe señalar que la consulta es un importante indicador de accesibilidad y utilización del sistema, de modo que la información que se expone resulta de suma relevancia para la planificación sanitaria","palabras_clave":"Salud|Financiación|Planificación|Obras Sociales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17646,"idioma_id":4,"titulo":"Nuclear localization of MUC1 extracellular domain in breast, head and neck and colon cancer primary tumors","resumen":"MUC1 is a glycoprotein overexpressed and underglycosylated in cancer cells. MUC1 is translated as a single polypeptide that undergoes autocleavage into two subunits, MUC1 extracellular and MUC1 cytoplasmic tail, and forms a stable heterodimer at the apical membrane of normal epithelial cells. MUC1 cytoplasmic tail localizes to the cytoplasm of transformed cells and is targeted to the nucleus. Aim: To study the expression of MUC1 extracellular subunit in the nucleus of breast, head and neck, and colon neoplastic samples. Materials and Methods: 330 primary tumour samples were analyzed: 166 invasive breast carcinomas, 127 head and neck tumours and 47 colon adenocarcinomas; 10 benign breast disease (BBD) and 40 normal specimens were included. A standard immunohistochemical approach with antigenic retrieval was performed. Nuclear fractions from tissue homogenates and from breast cancer cell lines (ZR-75-1, MDA-MB-231, MCF7 and T47D) were obtained, and thereafter analyzed by Western Blotting (WB). Anti-MUC1 extracellular subunit monoclonal antibody (MAb) HMFG1 was used. Results: by IHC with MAb HMFG1, 37\/166 (22,3%) breast cancer specimens, 5\/127 (4%) head and neck cancer specimens, 2\/47 (4%) colon cancer samples, 3\/10 BBD stained at nuclear level. Nuclear reaction was not detected in normal samples. By WB, breast and colon cancer purified nuclear fractions showed reactivity at 200kD in 3\/30 breast and 3\/20 colon cancer samples as well as purified nuclear fractions obtained from breast cancer cell lines. Conclusions: This study shows that MUC1 extracellular domain might be translocated to the nucleus of breast, head and neck, and colon cancer cells, and BBD samples.","palabras_clave":"MUC1 EXTRACELLULAR DOMAIN|NUCLEAR LOCALIZTION|NEOPLASIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17647,"idioma_id":4,"titulo":"Precipitation extremes over La Plata Basin - Review and new results from observations and climate simulations","resumen":"Monthly and daily precipitation extremes over La Plata Basin (LPB) are analyzed in the framework of the CLARIS-LPB Project. A review of the studies developed during the project and results of additional research are presented and discussed. Specific aspects of analysis are focused on large-scale versus local processes impacts on the intensity and frequency of precipitation extremes over LPB, and on the assessment of specific wet and dry spell indices and their changed characteristics in future climate scenarios. The analysis is shown for both available observations of precipitation in the region and ad-hoc global and regional models experiments. The Pacific, Indian and Atlantic Oceans can all impact precipitation intensity and frequency over LPB. In particular, considering the Pacific sector, different types of ENSO events (i.e. canonical vs Modoki or East vs Central) have different influences. Moreover, model projections indicate an increase in the frequency of precipitation extremes over LPB during El Niño and La Ninã events in future climate. Local forcings can also be important for precipitation extremes. Here, the feedbacks between soil moisture and extreme precipitation in LPB are discussed based on hydric conditions in the region and model sensitivity experiments. Concerning droughts, it was found that they were more frequent in the western than in the eastern sector of LPB during the period of 1962 to 2008. On the other hand, observations and model experiments agree in that the monthly wet extremes were more frequent than the dry extremes in the northern and southern LPB sectors during the period 1979 ? 2001, with higher frequency in the south.","palabras_clave":"Precipitation extremes|La Plata Basin|South America|Large-scale features"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17648,"idioma_id":5,"titulo":"Representaciones y prácticas de recepción de las personas mayores frente a los discursos sociales en el marco de la Ley de Medios argentina","resumen":"El presente trabajo tiene como principal objetivo dar cuenta del trabajo de investigación tendiente a reconocer a los adultos mayores de ciudades bonaerenses como públicos receptores de medios de comunicación y de los nuevos dispositivos de la cultura y la información digitales. En particular, se busca conocer representaciones y prácticas de recepción de las personas adultas mayores respecto de la televisión y la radio nacionales, junto con sus restantes prácticas culturales de consumo.  En el inicio de la indagación, se desarrolló una encuesta sobre preferencias, prácticas de consumo y posicionamientos frente a los medios, el periodismo y los periodistas nacionales. Se incluyeron además exploraciones sobre el acceso y los usos de las tecnologías de la comunicación en este  sector sociocultural.   En esta instancia,  se comparten resultados en torno a las representaciones y discursos propios de las personas mayores que se confrontaran a futuro con los discursos predominantes de las producciones mediáticos audiovisuales, enraizados su mayoría en estereotipos y prejuicios. Desde el punto de vista comunicacional la indagación propone aportar desde la universidad pública nuevas miradas, reflexiones que apunten a la realización de contenidos y formatos a la TV y la radio públicas y comunitarias, en tiempos  de la implementación de la Ley 26.522 de Servicios de Comunicación Audiovisual  Se particulariza aquí en el público adulto mayor, a fin de obtener elementos analíticos y críticos para las reformulaciones que sean necesarias realizar por los medios de comunicación, buscando así potenciar acciones que beneficien a dicha etaria.","palabras_clave":"MEDIOS|RECEPCION|ADULTOS  MAYORES|LEY DE MEDIOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17649,"idioma_id":4,"titulo":"Mechanical, electrochemical and magnetic behaviour of duplex stainless steel for biomedical applications","resumen":"Mechanical,  electrochemical and magnetic properties of duplex stainless steel were analysed  to evaluate its use as biomaterial, comparing the results with those obtained  for austenitic stainless steel. Yield and ultimate tensile strengths are almost  twice in duplex stainless steel, being the values 870 MPa and 564 MPa,  respectively. The electrochemical test revealed that this material has lower  susceptibility to localised corrosion because of its greater passive range, 1 V  from the open circuit potential, while the austenitic stainless steel exhibited  a passive region of 0.370 V. Both steels behave as soft magnetic materials,  however, duplex stainless steel has higher magnetic saturation and remanence,  while austenitic stainless steel is more prone to heating when exposed to a  magnetic field.","palabras_clave":"Biomaterials|Duplex stainless steel|Mechanical properties|Electrochemical properties|magnetic properties"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17650,"idioma_id":5,"titulo":"Enseñanza integrada de anatomía e histología en la facultad de odontología de la Universidad Nacional de Córdoba, Argentina","resumen":"Introducción. Docentes de anatomía, histología y asesoría pedagógica conformaron un equipo para diseñar e implementar una experiencia de enseñanza integrada (EI) en la Facultad de Odontología, Universidad Nacional de Córdoba, Argentina. El objetivo fue promover una mayor integración entre la anatomía e histología del sistema estomatognático y guiar la transferencia a situaciones clínicas.Materiales y métodos. En 2010 se rediseñó una propuesta sobre EI para su aplicación a la totalidad de alumnos y con todos los docentes, quienes participaron en ateneos interdisciplinarios para la actualización de contenidos, unificación de criterios, etc. Los alumnos realizaron cuatro clases teórico-prácticas y un trabajo práctico elaborado sobre un caso clínico, con la participación de un docente de anatomía y otro de histología. En el trabajo práctico, los alumnos efectuaron una exploración guiada de la cavidad bucal y trabajaron grupalmente para resolver preguntas sobre el caso clínico. Evaluaron cada actividad de EI, indicando aspectos positivos y a mejorar. Los docentes se expresaron a través de una encuesta.Resultados. Los alumnos destacaron que el abordaje integrado les permitió una mejor comprensión y relación de los temas de las dos asignaturas; valoraron el dinamismo, las explicaciones claras y bien ilustradas de las clases, y el trabajo sobre situaciones clínicas. Los docentes consideraron que la EI es una experiencia positiva, desafiante, enriquecedora, que mejora los nexos con sus colegas y alumnos.Conclusiones. La experiencia de EI permitió lograr los objetivos de aprendizaje propuestos para los alumnos y constituyó una valiosa oportunidad formativa para los docentes.","palabras_clave":"ANATOMÍA|HISTOLOGÍA|ENSEÑANZA INTEGRADA|SISTEMA ESTOMATOLÓGICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17651,"idioma_id":4,"titulo":"Stakeholder?s analysis in e-learning software process development","resumen":"The success of an e-learning project depends largely on the quality of applications and tools used to support the learning process. Meanwhile, the quality of software depends largely on proper stakeholders? identification in the requirements stage during the development process. Although some studies exist which have identified key stakeholders in e-learning domain, most of them do not perform a deep analysis of the stakeholders and their contexts, necessary to consider educational and cultural issues in this type of environment. The aim of this paper is to present the application of a method for the identification and analysis of stakeholders, which is adapted to e-learning domain. This method was used in a case study considering university environments.","palabras_clave":"STAKEHOLDERS|E-LEARNING DOMAIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17652,"idioma_id":5,"titulo":"Del bombo legüero a la batería.  Modificaciones rítmico-texturales en la chacarera","resumen":"Resumen  El presente trabajo analiza el cambio acaecido en el folklore profesional en Argentina, y más precisamente en la chacarera, a partir de la inclusión de la batería como instrumento rítmico-percusivo.   La hipótesis es que este cambio resulta significativo porque provoca una modificación en la función textural de acompañamiento de la percusión, transformando un rasgo jerarquizado en la constitución de estos géneros. En este sentido, es posible afirmar que esta modificación ha producido un cambio estético de importancia dentro de la escena folklórica.   En primer lugar el trabajo aborda algunas nociones que resultan pertinentes para nuestra argumentación tales como la idea de ?jeraquía? en los rasgos que definen al género musical, la noción de ?función textural? y las características rítmicas de la chacarera y los géneros ternarios del folklore en Argentina. Seguidamente se presentan algunos artistas y discos que fueron pioneros en la incorporación de la batería en este repertorio con anterioridad a la década de 1990. Finalmente, y dado que el rol de la batería en el rock es el que se expande hacia otras escenas, se exponen algunos conceptos sobre el patrón característico y la función textural de la batería (en el rock) de modo de contar con los elementos necesarios para la argumentación central del trabajo: la modificación rítmico-textural en la escena folklórica.  Folklore argentino ? bombo legüero ? batería ? ritmo ? textura  Abstract  In this paper we analyze the changes that occurred in the professional folklore in Argentina, and more precisely in the chacarera, after the inclusion of the drum kit as a rhythmic-percussive instrument.  The hypothesis is that this shift is significant because it causes a change in the textural function of the percussion accompaniment, transforming a hierarchical feature in the constitution of these genres. In this sense, we can state that this modification has been a major aesthetic change in the folk scene.  First, the paper addresses some notions that are relevant to our argument such as the idea of ´hierarchy´ on the traits that define the genre; the notion of ?textural function?;  and rhythmic characteristics of the chacarera and other ternary genres in the argentine folklore. Subsequently we present some artists and albums that pioneered the incorporation of the drum kit in this repertoire prior to the 1990.  Finally, given that the source of the use of the set of drums in professional folklore and other scenes, came from rock, we will expose some characteristics ot the textural patterns and other functions of  the drums in rock music, in order to  have the necessary elements  to introduce the central argument of the work: the rhythmic-textural change in the folk scene.  Argentine folk music ? bombo legüero ? drum kit ? rhythm -  texture","palabras_clave":"Folklore argentino|bombo legüero|bateria|ritmo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17653,"idioma_id":5,"titulo":"Flavonoides de Calendula officinalis L. bajo cultivo: efecto de diferentes fechas de siembra y fertilización fosforada","resumen":"Calendula officinalis L. (Asteraceae) ?caléndula? es una hierba anual con capítulos amarillos o anaranjados utilizada popularmente por sus propiedades antidermatósica, antiinflamatoria, antiespasmódica, emenagoga, entre otras. Muchas de sus propiedades curativas son debidas a los flavonoides contenidos en las flores del capítulo. Recientemente se ha incrementado el volumen de producción de caléndula debido a la incorporación de tecnologías y a la elección de cultivares adecuados para cada zona. El objetivo del presente trabajo ha sido evaluar el rendimiento de flavonoides del cultivo de Calendula officinalis L. en función de tres fechas de siembra (F1-13\/5\/11, F2-10\/6\/11 y F3-8\/7\/11) y tres niveles de fertilización fosforada (T0-0 Kg P2O5\/ha, T1-23 Kg P2O5\/ha y T2-46 Kg P2O5\/ha). El ensayo fue conducido en el campo experimental de la Universidad Nacional de Luján. Se utilizaron semillas de C. officinalis var. Mistura. El fertilizante fue aplicado en bandas paralelas al surco, simultáneamente con la siembra. El diseño experimental fue completamente aleatorizado con 4 repeticiones por tratamiento. El perfil cromatográfico cualitativo y el contenido total de flavonoides fueron determinados mediante cromatografía en capa delgada y espectrofotometría. Todos los tratamientos ensayados cumplen con el perfil cromatográfico cualitativo de Calendula officinalis L. descripto por la Farmacopea Argentina. Los mayores contenidos de flavonoides (0,44 a 0,56%) se registraron en las muestras de los tratamientos de siembra de junio (F2). El uso de 46 Kg P2O5\/ha (T2) produjo porcentajes de flavonoides totales superiores a 0,4 % en las siembras de junio y julio, mientras que todos los tratamientos de fertilización sembrados en mayo presentaron un contenido de flavonoides totales inferior a 0,4 %. Así, para lograr un adecuado porcentaje de contenido de flavonoides en el cultivo de caléndula en la zona noreste de la provincia de Buenos Aires, es recomendable sembrar en el mes de junio y con una fertilización fosforada de 46 Kg P2O5\/ha.","palabras_clave":"calendula|cultivo|flavonoides|fertilización"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17654,"idioma_id":4,"titulo":"Surface localization of high-mobility group nucleosome-binding protein 2 (HMGN2) on leukemic B cells from chronic lymphocytic leukemia patients is related to secondary autoimmune hemolytic anemi","resumen":"Chronic lymphocytic leukemia (CLL) is the main cause of autoimmune hemolytic anemia (AHA). However, the cellular basis underlying this strong association remains unclear. We previously demonstrated that leukemic B cells from patients with CLL recognize the erythrocyte protein Band 3, a prevalent autoantigen in AHA. Here we show that the major binding site of Band 3 on leukemic cells is an extrinsic protein identified as high-mobility group nucleosome binding protein 2 (HMGN2), a nucleosome-interacting factor which has not been previously reported at the cell surface. T lymphocytes do not express HMGN2 or bind Band 3. Removal of HMGN2 from the cell membrane abrogated the capacity of Band 3-pulsed CLL cells to induce CD4 + T cell proliferation. We conclude that surface HMGN2 in leukemic B cells is involved in Band 3 binding, uptake and presentation to CD4 + T lymphocytes, and as such may favor the initiation of AHA secondary to CLL.","palabras_clave":"LEUKEMIA|HMGN2|ANEMIA |AUTOIMMUNITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17655,"idioma_id":4,"titulo":"Neo-sex chromosomes of Ronderosia bergi: insight into the evolution of sex chromosomes in grasshoppers","resumen":"Sex chromosomes have evolved many times from morphologically identical autosome pairs, most often presenting several recombination suppression events, followed by accumulation of repetitive DNA sequences. In Orthoptera, most species have an X0&#9794; sex chromosome system. However, in the subfamily Melanoplinae, derived variants of neo-sex chromosomes (neo-XY&#9794; or neo-X1X2Y&#9794;) emerged several times. Here, we examined the differentiation of neo-sex chromosomes in a Melanoplinae species with a neo-XY&#9794;\/XX&#9792; system, Ronderosia bergi, using several approaches: (i) classical cytogenetic analysis, (ii) mapping via fluorescent in situ hybridization of some selected repetitive DNA sequences and microdissected sex chromosomes, and (iii) immunolocalization of distinct histone modifications. The microdissected sex chromosomes were also used as sources for Polymerase chain reaction (PCR) amplification of RNA-coding multigene families, to study variants related to the sex chromosomes. Our data suggest that the R. bergi neo-Y has become differentiated after its formation by a Robertsonian translocation and inversions, and has accumulated repetitive DNA sequences. Interestingly, the ex autosomes incorporated into the neo-sex chromosomes retain some autosomal post-translational histone modifications, at least in metaphase I, suggesting that the establishment of functional modifications in neo-sex chromosomes is slower than their sequence differentiation.","palabras_clave":"RB-TRANSLOCATION|NEO-SEX CHROMOSOMES|FISH|REPETITIVE DNA|HISTONE MODIFICATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17656,"idioma_id":5,"titulo":"Teorías de la reproducción y teorías de la resistencia: una revisión del debate pedagógico desde la perspectiva materialista","resumen":"La pregunta por si la escuela constituye un espacio de transformación social es central dentro del pensamiento pedagógico moderno y, en particular, de las últimas décadas del siglo XX. Las «teorías de la resistencia» surgidas en los 80? y 90? apuntaron a mostrar el potencial transformador de la escuela a partir del desarrollo de una pedagogía crítica, en discusión con las denominadas «teorías dela reproducción» de los 70? que denunciaban el papel reproductor de la escuela en el capitalismo. Este artículo se propone revisar esta discusión y, particularmente, la forma antagónica que ha asumido, desde una perspectiva materialista. Para ello, se revisitarán los planteos clásicos de ambos grupos teóricos identificando que, aunque parecen antagónicos, coinciden en un punto central: consideran que las relaciones sociales capitalistas son exteriores a los sujetos, es decir, que se les imponen sobre su libre subjetividad. Mientras las «teorías de la reproducción» plantean que solo se pude enfrentar tal dominación a partir de la lucha de clases por fuera de la escuela, las «teorías de la resistencia» postulan que la lucha puede darse en el plano ideológico dentro de la práctica escolar. El planteo de este artículo es que tal imposición externa es una apariencia producto del carácter enajenado de la conciencia que impide analizar que las relaciones sociales, lejos de imponérsenos, son las que entablamos los hombres para organizar el trabajo social. Para trascender esas apariencias, se realizará un proceso de reconocimiento de las determinaciones generales de la educación en el capitalismo que nos permitirá salir de una lógica binaria entre reproducción o resistencia, para pensar la transformación como parte del propio proceso de organización social.","palabras_clave":"ESCOLARIZACION|SOCIEDAD CAPITALISTA|PEDAGOGIA CRITICA|MATERIALISMO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17657,"idioma_id":4,"titulo":"Orchiectomy attenuates oxidative stress induced by aluminum in rats","resumen":"Orchiectomy attenuates oxidative stress induced by aluminum in rats Mar&#305;´a del Carmen Contini, Ne´stor Millen, Marcela González, Adriana Benmelej, Ana Fabro and Stella Mahieu Abstract The aim of this work was to study whether the increase in antioxidant defenses associated with orchiectomy may account for the reduced susceptibility to aluminum (Al) in male kidney and also to examine whether the reduced antioxidant defenses are associated with androgen levels in orchiectomized (ORX) rats treated with testosterone propionate (TP). Rats were divided into nine groups, namely, intact males (without treatment, treated with sodium lactate, and treated with Al), sham males, ORX males (without treatment, treated with sodium lactate, treated with TP, treated with Al, and treated with TP and Al). Al groups were chronically treated with aluminum lactate for 12 weeks (0.575 mg Al\/100 g of body weight, intraperitoneally, three times per week). We reported that ORX rats treated with Al had significantly less lipid peroxidation and an increased level of reduced glutathione (GSH) and GSH\/oxidized glutathione ratio in the kidney when compared with intact and TP-treated ORX rats. The activity of superoxide dismutase, catalase, and glutathione peroxidase in ORX rats was much greater than in intact or TP-administered ORX rats. Castration reduced the glomerular alterations caused by Al as well as the number of necrotic tubular cells and nuclear abnormalities. However, we observed a slight alteration in brush border, dilation of proximal tubules, mononuclear infiltrates, and interstitial fibrosis. Castrated males treated with TP showed that this intervention cancels the protective effect of the ORX. This finding suggests that androgens contribute to the development of renal alterations and proteinuria in rats treated with Al. Our results showed that ORX rats are protected against the induction of oxidative stress by Al, but the morphological damage to the kidney tissue induced by the cation was only reduced. Male intact rats treated with Al had more severe glomerulosclerosis, tubular damage, and proteinuria than ORX rats.","palabras_clave":"ORCHIECTOMY|OXIDATIVE STRESS|ALUMINUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17658,"idioma_id":5,"titulo":"Pérdidas productivas y económicas diarias ocasionadas por la mastitis y erogaciones derivadas de su control en establecimientos lecheros de Córdoba, Argentina","resumen":"El propósito de este estudio fue estimar los costos diarios directos de la mastitis y las erogaciones derivadas de su control y prevención, y describir su magnitud y variación entre establecimientos lecheros de una de las principales cuencas lecheras de Argentina. Una muestra aleatoria de establecimientos lecheros (n = 48) fueron visitados una sola vez. En todas las vacas en ordeño se verificó la presencia de mastitis clínica (MC) y a 1.955 vacas seleccionadas aleatoriamente se les extrajo muestra compuesta de leche para determinación de recuento celular somático (RCS). Simultáneamente, se examinó la rutina de ordeño y se analizó una encuesta aplicada al encargado de ordeño. Se caracterizaron y cuantificaron las pérdidas productivas y económicas de acuerdoal RCS, en concepto de leche descartada por MC y las erogaciones por acciones de control y prevención. La mediana de pérdidas directas invisibles fue de 2,8 litros\/vaca\/día (percentil 25% = 2,0; percentil 75% = 2,9) para el conjunto de animales en estudio, representando un costo de 0,99 US$\/vaca\/día.La mediana de pérdidas en el establecimiento atribuidas a MC fue de 0,12 litros\/vaca\/día (percentil 25% = 0; percentil 75% = 0,31), representando un costo de 0,04 US$\/vaca\/día. La mediana de pérdidas indirectas fue de 0,06 US$\/vaca\/día (percentil 25% = 0,034; percentil 75% = 0,095). En el 50% de los establecimientos, el costo total, es decir, adicionando las pérdidas en producción de leche a los gastos del control y prevención fue &#8805; 1,0 US$\/vaca\/día (percentil 25% = 0,8; percentil 75% = 1,2). El costo total de la mastitis, representó en promedio un 16% de los ingresos brutos diarios en al menos la mitad de los establecimientos. Al analizar los establecimientos de acuerdo a tres niveles de producción, no se observaron diferentes perfilesde costos; con excepción de la relación costos sobre ingresos brutos, la que fue mayor en el estrato de menor producción. Este es el primer trabajo que explora diferencias de costos de la mastitis entre una muestra aleatoria de productores lecheros de Argentina.","palabras_clave":"mastitis bovina|impacto economico|costo total de mastitis|perdidas directa por mastitis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17659,"idioma_id":4,"titulo":"Mechanistic evaluation of hematin action as a horseradish peroxidase biomimetic on the 4-aminoantipyrine\/phenol oxidation reaction","resumen":"    Hematin, a mimetic structure of heme  peroxidases, was successfully applied for H2O2-mediated  condensation reaction between phenol and 4-aminoantipyrine.The catalytic action  was evaluated in comparison to horseradish peroxidase (HRP) by kinetic  modelling and parametrization procedure. Expected side reactions were checked  and discarded as model-relevant routes. The existence of the oxoperferryl-p-cation radical and oxoperferryl species of  hematin, as analogues of Compound I and II of HRP, can be postulated because simulated product formation fitted  experimental data. However, in light of the optimized rate constants  encountered, hematin was less active to peroxide activation and less specific  to the coordination of phenol versus H2O2 than HRP. The  model indicated that hematin bleaching from key intermediate oxoperferryl was  induced rather than regenerated via Compound III formation. In contrast to the enzyme,  the faster oxygen evolvement and the lack of precipitating polyphenol  production observed with hematin after 4-aminoantipyrine depletion were  interpreted as accumulation of oxidising HOO· radicals  through the peroxide decomposition pathway. This study may be of interest for  interpreting the catalytic performance of hematin. Moreover, the replacement of  the enzyme by the less-expensive and non-polyphenol-forming hematin for this  versatile colorimetric assay may provide convenient results, especially in flow-injection  modes and analytical columns applications.  ","palabras_clave":"HEMATIN|HORSERADISH PEROXIDASE|REACTION MECHANISM|KINETIC MODELING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17660,"idioma_id":4,"titulo":"'Adsorption of 2-propanol on MgO Surface: A Combined Experimental and Theoretical Study'","resumen":"        The adsorption of 2-propanol (or isopropanol) on MgO was studied using infrared        (IR) spectroscopy and density functional theory (DFT) simulations. The analysis of IR        spectra indicates that the molecule can adsorb either molecularly or dissociatively. DFT        calculations show that the adsorption mode depends on the active site of the catalyst.        While on perfect terrace it adsorbs non-dissociatively, on edge and on three-fold        coordinated O anion (O-corner sites) the adsorption occurs dissociatively by breaking        the O-H bond without activation barrier giving 2-propoxide and a surface hydroxyl        group. Calculations also suggest that vacant oxygen centers on terrace, edge and corner        are also possible sites for non-dissociative adsorption. On Mg ions located at corners the        adsorption is strong but non-dissociative, while on a Mg vacancy at the same position        the molecule easily dissociates. Frequency modes are also calculated and compared in        detail with experimental IR spectra.","palabras_clave":"2-PROPANOL|ADSORPITON|MgO|FTIR|DFT|CLUSTER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17661,"idioma_id":4,"titulo":"Glycerolysis of methyl oleate on MgO: experimental and theoretical study of the reaction selectivity","resumen":"The liquid-phase MgO-promoted glycerolysis of methyl oleate, a fatty acid methyl ester (FAME), to give acylglycerol products was studied both, experimentally and by density functional theory (DFT). Catalytic results showed that strongly basic low coordination O2 surface sites participate in kinetically relevant steps of the glycerolysis reaction. Changes in the selectivity toward the different mono- and diglyceride isomers were investigated by varying the reaction conditions. The main product was always a-glyceryl monooleate (a-MG), a monoglyceride with the ester fragment at one of the terminal positions of the glycerol molecule; the b-MG isomer, with the ester substituted at position 2 was obtained in much lower amounts.The molecular modeling of glycerol (Gly) and FAME adsorptions as well as of the glycerolysis reaction was carried out using periodic DFT calculations and a Model of stepped MgO surface. Results indicated that FAME was more weakly adsorbed than Gly; the latter adsorbs on a coordinatively unsaturated surfaceO2 site with OAH bond breaking at position 2 of the Gly molecule, giving therefore a surface b-glyceroxide species. Calculations explained the apparent contradiction between the preferential formation of the a-MG isomer and the energetically favored dissociation of the secondary OH group of Gly that leadsto the b-glyceroxide species. They predict that the b-glyceroxide species participates in the pathways conducting to both, a- and b-MG isomers. Synthesis of a-MG occurs by CAO coupling of b-glyceroxide with FAME at one of the two primary OH groups of the b-glyceroxide species. Two transition states (TS) and a tetrahedral intermediate (TI) are involved in both, a-MG and b-MG isomer formation. However, the pathway toward b-MG is limited by the large sterical effects associated to the TI formation. Contrarily, the TI leading to a-MG is relatively easy to form.","palabras_clave":"GLYCEROLYSIS|MONOGLYCERIDE|ISOMER SELECTIVITY|DFT|BASE CATALYSIS|MOLECULAR MODELING|PERIODIC CALCULATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17663,"idioma_id":5,"titulo":"Análisis de Variables Temporales para la Predicción del Consumo Eléctrico","resumen":"Short Term Load Forecasting (STLF) currently is a major importance issue for Energy Companies. STFL allows a more efficient manage and use of resources and equipment. The electric demand prediction is a complex issue, since it depends or is related to economic factors, climate and time to mention a few. Furthermore, its behaviour changes from one society to another. Each factor provides a particular variable that could be presented in different forms, particularly the time variables. In this paper we present the hypothesis that the way an input variable is introduced to an energy prediction system affects the result. To validate this hypothesis, different methods to represent time variables were considered and applied to the prediction problem of daily electric consumption in Tucumán, a province of Argentina. The separation of the time variables into single variables representing the day, day of the week, month and year for each period involved into the problem, was the most convenient method. The improvement of this method was about the 10 % in comparison to the others.","palabras_clave":"Energy Consumption|Short Term Load Forecasting|Variable Selection|Linear Regresion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17664,"idioma_id":4,"titulo":"Hybrid organic-inorganic silica-based coatings deposited by spray technique","resumen":"AISI 316L stainless steel is mainly used in biomedical applications, even though it suffers localized corrosion. Its protection can be achieved creating a barrier for ions migration. This paper presents the synthesis and deposition of sol gel coatings over AISI 316L, done by spray and dip-coating method, using tetraethoxysilane (TEOS), methyltriethoxysilane (MTES) and colloidal silica nanoparticles as precursors. Both coatings are analysed by optical microscopy, mechanical profilometry and electrochemical tests in simulated body fluid solution. The spray deposition technique is presented as a versatile way to generate thin layers enabling to coat complex geometries and being promising for industrial purposes.","palabras_clave":"THIN FILMS|SOL-GEL COATINGS|STAINLESS STEEL|SPRAY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17665,"idioma_id":4,"titulo":"Electron-capture-to-continuum cusp in U$^{88+}$ + N$_2$ collisions","resumen":"For the collision system U8+ + N2 a collision energy of 90 MeV\/u, the energy distribution of electrons being nonradiatively captured from the target into the projectile continuum has been measured under an angle of 0º with respect to the projectile beam axis. This measurement of the electron-capture-to-continuum cusp with the highest effective projectile charge Zpeff=88 at a near-relativistic collision velocity of &#946;&#8776;0.41 is shown to be characterized by a strong asymmetry in the cusp shape. By comparing the data to measurements of the radiative-electron-capture-to-continuum cusp for the same collision system, the opposite asymmetry of the cusp is traced back to the varying underlying mechanisms. The experimental results are compared with the two theoretical calculations available for this process, one of them in the semirelativistic impulse approximation and the other in the nonrelativistic continuum-distorted-wave approach. A corresponding fully relativistic treatment may be motivated by the presented experimental data.&nbsp;","palabras_clave":"ELECTRON|CAPTURE-TO-CONTINUUM|HIGHLY-CHARGED-IONS|RELATIVISTIC|COLLISIONS|EXPERIMENTAL|THEORETICAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17666,"idioma_id":4,"titulo":"Transport of interacting particles in a chain of cavities: Description through a modified Fick-Jacobs equation","resumen":"We study the transport process of interacting Brownian particles in a tube of varying cross section. To describe this process we introduce a modified Fick-Jacobs equation, considering particles that interact through a hard-core potential. We were able to solve the equation with numerical methods for the case of symmetric and asymmetric cavities. We focused in the concentration of particles along the direction of the tube. We also  preformed Monte Carlo simulations to evaluate the accuracy of the results, obtaining good agreement between theory and simulations.","palabras_clave":"TRANSPORT|HARD-CORE|DIFUSSION|CAVITIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17667,"idioma_id":4,"titulo":"Brass corrosion in chlorinated tap water inhibited by phosphate ions","resumen":"The combined effect of phosphate ions as corrosion  inhibitor and sodium hypochlorite as biocide is studied on  aluminum brass in contact with artificial tap water. The interaction  between phosphates and hypochlorite was evaluated by  electrochemical techniques for films formed between 2 and  192 h and by weight loss tests for immersion times of 90 days.  Raman spectroscopy and X-ray photoelectron spectroscopy  were used to study the passive layer. When the biocide agent  is present, dezincification is the predominant form of localized  corrosion after long time exposures. When the inhibitor is  present , a nobler pitting potential was found.  Electrochemical impedance spectroscopy (EIS) results suggest  the development of a compact passive layer, regardless  of the presence of the biocide. No localized attack was detected  on samples immersed for 90 days at open circuit potential  in the presence of phosphates, even when NaClO is present.  Weight loss analysis showed inhibition efficiencies higher  than 90 % when phosphates and the biocide are present. The  oxidative nature of NaClO could favor Zn dissolution and  enhance the precipitation of Zn3(PO4)2 layer, producing a  more compact surface laye","palabras_clave":"Aluminum brass |Phosphate|Corrosion inhibition|Sodium hypochlorite"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17668,"idioma_id":5,"titulo":"MORFOHISTOLOGÍA TESTICULAR DE Hypsiboas pulchellus (AMPHIBIA, HYLIDAE) DURANTE LA ESTACIÓN REPRODUCTIVA","resumen":"En este estudio se aportan datos sobre la morfohistología  testicular de Hypsiboas pulchellus durante el período  reproductivo con el fin de conocer aspectos de su biología reproductiva. Los  testículos, ovoides y amarillentos de 4,64 ± 0,48 mm de largo por 2,05 ±  0,23 mm  de ancho, están rodeados por la túnica albugínea que mide 5,60 ± 0,82 &#956;m.  Internamente presentan lóculos seminíferos de 257,47 ± 58,25 &#956;m de diámetro,  distinguiéndose en ellos cistos con células espermatogénicas asociadas a  células de Sertoli. Existe escaso tejido intersticial. Las espermatogonias I  son las células más grandes de la serie germinal (14,34 ± 1,74 &#956;m), estas  originan a las espermatogonias II (10,14 ± 1,33 &#956;m). Los espermatocitos I  presentan la cromatina levemente condensada midiendo 9,34 ± 0,32 &#956;m. Los  espermatocitos II miden 8,12 ± 1,07 &#956;m. Las espermátidas I son esféricas, miden  7,61 ± 1,45 &#956;m, y se agrupan en cistos redondeados. Las espermátidas II, en  cambio, son alargadas, no hallándoselas dentro de cistos (4,09 ± 0,51 &#956;m). Los  espermatozoides, alargados y flagelados, se hallan libres en el centro del  lóculo. La morfohistología de los testículos analizados muestra características  similares a las observadas en otros anfibios neotropicales, y presentan todas  las células del linaje espermatogénico en un mismo lóculo.","palabras_clave":"ANFIBIO NEOTROPICAL|BIOLOGÍA REPRODUCTIVA|HISTOLOGÍA TESTICULAR|HYPSIBOAS PULCHELLUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17669,"idioma_id":4,"titulo":"Weighted binary relations involving the Drazin inverse","resumen":"The Drazin inverse of a matrix has been used in the literature to define a pre- order on the set of square complex matrices. In this paper we analyze new binary relations defined on the set of rectangular complex matrices and some relationships to the W-support idempotent. We introduce the class of weighted Drazin equal projectors and analyze the pre-orders on this class. Moreover, adjacent matrices are studied under the considered relations. Finally, some observations on weighted partial orders are given.","palabras_clave":"Drazin inverse|Drazin pre-order|sharp partial order"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17670,"idioma_id":5,"titulo":"Rendimiento Potencial de maíz","resumen":"Rendimiento Potencial de maíz","palabras_clave":"."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17671,"idioma_id":5,"titulo":"Anatomía y morfogénesis de las agallas producidas por Leptocybe invasa en plantas de Eucalyptus","resumen":"Leptocybe invasa o ?avispa de la agalla del eucalipto?, es un microhimenóptero gallícola que ovipone en hojas jóvenes de eucaliptos. La planta responde formando agallas, que causan enrollamiento, defoliación y colapso de brotes, afectando seriamente la producción. En este trabajo se analizan los cambios morfogenéticos y anatómicos provocados por el desarrollo de las agallas, comparándolos con plantas sanas. Con técnicas tradicionales de microscopía óptica y electrónica de barrido se estudiaron ejemplares de Eucalyptus grandis y E. camaldulensis, cultivados en Corrientes, Argentina. La avispa ovipone entre los haces vasculares, el vegetal produce un tejido hiperplásico que se diferencia en cuatro estratos: nutricio, esclerosado, tanífero y cristalífero. El recorrido de los tejidos vasculares se obstruye, produciéndose ?bucles xilemáticos? que interrumpen el flujo normal de agua y fotosintatos. Analizando los cambios morfológicos y anatómicos, junto al desarrollo del insecto, se divide el ciclo en tres etapas. Este trabajo demuestra que la formación de agallas en Eucalyptus representa un excelente ejemplo de fenotipo extendido, donde la acción de L. invasa induce al crecimiento anormal de los tejidos vegetales, tanto en aumento del número de células, colapso del sistema vascular de la zona afectada y aparición de nuevas características anatómicas.","palabras_clave":"Leptocybe invasa|AGALLAS|EUCALIPTOS|MORFOGENESIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17672,"idioma_id":4,"titulo":"Polar Diels-Alder reactions using electrophilic nitrobenzothiophenes. A combined  experimental and DFT study.","resumen":"The reactions between 2- and 3-nitrobenzothiophenes with three dienes of different nucleophilicity, 1-methoxy-3-trimethylsilyloxy-1,3-butadiene, 1-trimethylsilyloxy-1,3-butadiene and isoprene developed in anhydrous benzene and alternative under microwave irradiation with molecular solvents or in free solvent conditions, respectively, produce dibenzothiophenes and permit to conclude that both nitroheterocycles act as electrophile with the cited dienes. In the cases of the dienes 1-methoxy-3-trimethylsilyloxy-1,3-butadiene and 1-trimethylsilyloxy-1,3-butadiene which posses major nucleophilicity the observed product is the normal cycloaddition one. However when the diene is isoprene the product with both electrophiles follow the hetero Diels-Alder way.   These reactions are considered polar cycloaddition reactions and the yields are reasonables.   Moreover the polar Diels-Alder reactions of nitrobenzothiophenes with the electron rich dienes 1-trimethylsilyloxy-1,3-butadiene have been theoretically studied using DFT methods.","palabras_clave":"DIELS-ALDER|NITROBENZOTHIOPHENES|DFT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17673,"idioma_id":4,"titulo":"Tidal Suppression Negatively Affects Soil Properties and Productivity of Spartina densiflora Salt Marsh","resumen":"In order to intensify cattle utilization, embankments were constructed to avoid tidal ingressions in Samborombon Bay, Argentina, The objective of this study was to evaluate the effect of tidal suppression and cutting frequency of a saltmarsh dominated by Spartina densiflora Brongn. Two paddocks of a commercial cow-calf operation farm, one prevented fromtidal flooding and another exposed to overflow fromnatural tidal pattern (control), were the main plots of the nested design. The experiments were carried out during a dry (2008- 2009) and awet growing season (2012-2013). Two defoliation frequencies, simulatinglight and moderate grazing pressure, were performed in the subplots nested within each main plot. Soil organicmatter and N content were lower and soil structural instability index wasmuch higher in the embankment than in the control treatment. Soil salinity during the dry growing seasonwas higher in the embankment than in the control treatment. Bare soil was higher under embankment treatment and high defoliation frequency exacerbated this response. Relative contribution of Spartina densiflora was lower under embankment than control treatment and the changes of floristic composition depended on the growing season. Aboveground net primary production (ANPP) in the wet growing season was almost70% higher than in the dry growing season. Embankment reduced ANPP and high defoliation increased ANPP with respect to low defoliation frequency in the control paddock, to a much higher extent in the wet season. Dry matter digestibility of S. densiflora was not affected by treatments. Crude protein was higher in control paddocks under high frequency. Our results showed that tidal suppression by embankment was not effective to increase productivity and forage value of S. densiflora saltmarsh but caused soil and structural changes that may negatively alter ecosystem processes of this vulnerable grassland of high importance for biodiversity conservation.","palabras_clave":"OFERTA FORRAJERA|MANEJO SUSTENTABLE |PRODUCTIVIDAD PRIMARIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17674,"idioma_id":4,"titulo":"Draft genome sequence of Thermus sp. 2.9, isolated from a hot water spring located in Salta, Argentina","resumen":"Thermus sp. 2.9 was  isolated from a hot water spring in Salta, Argentina. Here we report the draft  genome sequence (2,485,434 bp) of this strain, consisting of 11 scaffolds  longer than 10 kbp and 2,719 protein-coding sequences.","palabras_clave":"Thermus sp. 2.9 |Draft Genome Sequence |Protein-coding Sequences"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17675,"idioma_id":4,"titulo":"Genome-wide association study for somatic cell score in Argentinean dairy cattle","resumen":"This study aimed to understand the genomic architecture of Argentinean dairy herds by measuring linkage disequilibrium (LD) and identifying loci associated with parameters calculated from somatic cell count (SCC). Phenotypic data consisted of 3530 SCC records from 544 Holstein and Holstein x Jersey cows owned by a single dairy company located in the Central dairy area of Argentina. SCC was recorded every 40 days. After quality control, genotypic data consisted in 38,872 single nucleotide polymorphisms (SNP). The squared correlation of the alleles at two loci (r2) was computed for all SNP pairs on each chromosome. At marker distances less than 10 kb the average r2 was 0.40. Between 40 and 50 kb the average r2 was 0.25 and 0.18 for 100 kb apart. Three different variables were calculated from the somatic cell score (SCS): the arithmetic mean (AM), the maximum value (MAX) and the arithmetic mean of the top 3 values (TOP3). Few significant SNP associations were found. As expected, polygenic traits such as SCC are influenced by multiple loci throughout the genome, each with a relatively small effect. AM on one side and TOP3 and MAX on the other, showed different SNP associated showing that they capture different aspects of mastitis response. AM was significantly associated with two SNP: ARS-BFGL-NGS-114608 (BTA1) and Hapmap60306-rs29023088 (BTA5). MAX and TOP3 were significantly associated with four SNP: ARS-BFGL-NGS-107594, ARS-BFGL-NGS-104220 (BTA10), BTA-43543-no-rs (BTA18) and ARS-BFGL-NGS-109705 (BTA26). MAX and TOP3 were equivalent phenotypic variables to be used in a GWAS. These results contribute to gain insight into the genomic regions influencing the SCC in Argentinean herds.","palabras_clave":"Mastitis|Resistance|GWAS|Milk"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17676,"idioma_id":4,"titulo":"Understanding the sensing mechanism of polyaniline resistive sensors.  Effect of humidity on sensing of organic volatiles.","resumen":"Polyaniline (PANI) is the oldest and potentially one of the most useful conducting polymers. Among other technological applications, PANI films have been extensively used as resistive sensors of volatile analytes. However, at present the mechanism underlying the resistivity changes of the films upon exposure to volatile substances is still unclear. In this work, we investigate different effects of the volatile absorption which can cause the changes polymer electrical resistance when it acts as resistive sensor. This model takes into account three major components: (i) changes in the electronic structure of the polymeric chains (&#916;Rele), (ii) variations in the electron hopping process (&#916;Rhop) and (iii) changes in the ionic conductivity between chains due to changes in the dielectric medium between them (&#916;Rmed). Using two point probe resistivity, UV?visible spectroscopy, environmental ellipsometric porosimetry and atomic force microscopy we study the effect of volatiles on polyaniline films properties to improve the understanding on the mechanism of resistivity changes. Specifically, in the case of water absorption, the resistivity changes seem to be associated with dielectric medium changes and swelling effects (in the high humidity range). It is found that ambient humidity not only gives a resistive signal but also strongly affect the sensing of other volatiles (e.g. ethanol).","palabras_clave":"RESISTIVE SENSOR|HUMIDITY|PLYANILINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17677,"idioma_id":4,"titulo":"Impact of cattle grazing on temperate coastal salt marsh soils","resumen":"Over thelast two decades, grazing intensity has increased in the temperate salt marshesof Samborombon Bay (Argentina) due to agricultural expansion and thedisplacement of domestic livestock to these areas. We investigated the effectof cattle grazing on soil chemical and physical properties in the higher (HE),medium (ME) and lower (LE) elevation levels of this temperate salt marsh. Soildata were collected from both a National Park, where cattle grazing has beenexcluded for more than 35 yrs, and an adjacent commercial livestock farm continuouslygrazed by cattle. We found that soil salinity was greater on the grazed than onthe ungrazed sites, especially those in the ME and LE. This could be related tothe upward flow of salts from the saline groundwater, driven by the increase inthe proportion of bare soil on grazed sites. The increase in soil salinitychanged the plant community structure through the increase of salt-tolerant andnon-palatable species and the decrease of palatable species. Soil physicalvariables (soil bulk density and soil bearing capacity) were also higher on thegrazed than on the ungrazed sites, which can be related to the decrease in soilorganic matter (SOM), and suggest an incipient compaction process; however, thevalues were still lower than those considered critical for plant growth in claysoils. These results suggest that continuous grazing management in thistemperate salt marsh might have negative consequences for animal production andecosystem conservation, mainly related to the increased soil salinity. Further researchwill be necessary to evaluate the suitability of switching to intermittentgrazing management.","palabras_clave":"COMPACTION|SALINITY|SOIL BULK DENSITY|BEARING CAPACITY|CATTLE GRAZING|SALT MARSH SOIL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17678,"idioma_id":4,"titulo":"The role of inoculum identity in drought stress mitigation by arbuscular mycorrhizal fungi in soybean","resumen":"It is well known that arbuscular mycorrhizal fungi(AMF) effects on plant growth largely depend on fungus identity.The objective of this study was to test whether threeindividual AMF isolates and their mixture mitigate droughtstress (DS) differentially in soybean (Glycine max) genotype,predicting that underDS, themixture of theAMFisolates wouldprovide greater benefits to soybean plants than individual ones.In a greenhouse experiment, a drought-susceptible soybeangenotype was inoculated with Septoglomus constrictum,Glomus sp., and Glomus aggregatum, known to be among themost abundant in agricultural and natural soils from centralArgentina, and their mixture (Mx). Whereas under wellwatered(WW) conditions, individual isolates andMx treatmentwere similarly infective; under DS conditions, theMx treatmentshowed lower rates of root colonization. Between WWand DSconditions, biomass was decreased in all treatments, althoughthis effect wasmoremarked in non-AM plants. Moreover,AMFstrains improved water content and P and N concentrations.Under DS, the Mx treatment was unable to exceed the highestcontents that were recorded by AMF isolates. However, underWW conditions, the Mx treatment showed a higher N contentthan individual isolates. Under both watering conditions, AMplants reduced oxidative damage evaluated as malondiadehydeand chlorophyll content and keep constant osmotic metabolitessuch as soluble sugars and proline content, without significantdifferences between AMF isolates and the Mx treatment. Theseresults show that AMF play an important role in mitigatingdrought impacts on soybean, but that mixtures of AMF isolatesdid not perform as well as the best single strain inoculum,excluding complementarity effects and suggesting selectioneffect of AMF on DS alleviation in soybean.","palabras_clave":"drought tolerance|oxidative stress|Glycine max|Glomeromycota mixed inocula"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17679,"idioma_id":4,"titulo":"Plant functional traits and phylogenetic relatedness explain variation in associations with root fungal endophytes in an extreme arid environment","resumen":"Since root endophytes may ameliorate drought stress, understanding which plants associate with endophytes is important, especially in arid ecosystems. Here we characterized the root endophytes of 42 plants from an arid region of Argentina. We related colonization by arbuscular mycorrhizal fungi (AMF) and dark septate endophytes (DSEs) to plant functional type (PFT), family, and phylogenetic relatedness. Overall, three main findings were observed. First, only moderate levels of endophyte associations were observed across all taxa (e.g. most Poaceae were not colonized by endophytes despite numerous accounts of colonization by AMF and DSEs). We determined 69% of taxa associated with some form of root endophyte but levels were lower than other regional studies. Second, comparisons by PFT and phylogeny were often qualitatively similar (e.g. succulents and Portulacineae consistently lacked AMF; variation among Bromeliaceae [terrestrial vs. epiphytic bromeliads]) and often differed from comparisons based on plant family. Third, comparisons by plant family often failed to account for important variation either within families (e.g. Bromeliaceae and Poaceae) or trait conservatism among related families (i.e. Rosidae consistently lacked DSEs and Portulacineae lacked AMF). This study indicates the value of comparing numerous taxa based on PFTs and phylogenetic similarity. Overall, these results suggest an uncertain benefit of endophytes in extremely arid environments where plant traits like succulence may obviate the need to establish associations. Keywords: arbuscular mycorrhizal fungi, dark septate endophytes, functional traits, phylogenetic trait conservatism, phylogentic trait divergence, xeric environment","palabras_clave":"DSE|AM|ARID|PLANT-FUNCTIONAL-TYPE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17680,"idioma_id":4,"titulo":"The first non-zero Neumann $p-$fractional eigenvalue","resumen":"In this work we study the asymptotic behavior of the first non-  zero Neumann p&#8722;fractional eigenvalue &#955;1(s, p) as s &#8594; 1 and as p &#8594; &#8734;.  We show that there exists a constant K such that K(1 &#8722; s)&#955;1(s, p) goes to  the first non-zero Neumann eigenvalue of the p&#8722;Laplacian.   While in the limit case p &#8594; &#8734;, we prove that &#955;1 (1, s)^{1\/p} goes to an eigenvalue of the Holder &#8734;&#8722;Laplacian.","palabras_clave":"FRACTIONAL LAPLACIAN|EIGENVALUE PROBLEM|NONLOCAL PROBLEM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17681,"idioma_id":5,"titulo":"Análisis bibliométrico de estudios empíricos en español sobre memoria de trabajo (1999-2014)","resumen":"La memoria de trabajo es un constructo multicomponente que permite la mantención de la información y su manipulación. El objetivo de este estudio fue analizar, mediante indicadores bibliométricos, los trabajos científicos de corte empíricovinculados al constructo memoria de trabajo, publicados en español en el período comprendido entre 1999 y 2014. Para ello, se realizaron búsquedas mediante palabras clave en cuatro bases de datos que incorporan literatura científicahispana: Dialnet, Lilacs, Scielo y Redalyc. Los resultados sugieren la necesidad de potenciar la producción regional en este campo. Por último, se discute acerca del impacto que puede proporcionar el estudio de la memoria de trabajo en elámbito laboral, educativo y clínico.","palabras_clave":"Estudio bibliométrico |Memoria de trabajo|Investigaciones empíricas |Idioma español"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17682,"idioma_id":4,"titulo":"High genetic diversity in the harvestman Geraeocormobius sylvarum (Arachnida, Opiliones, Gonyleptidae) from subtropical forests in north-eastern Argentina revealed by mitochondrial DNA sequences","resumen":"This research was aimed to analyze the genetic diversity of  Geraeocormobius sylvarum, a forest-dwelling Neotropical harvestman with  a disjunct distribution, separated by approximately 630 km of semi-arid  environments. The usefulness of a fragment of the Cytochrome C Oxidase  subunit I (COI) mitochondrial gene as molecular marker was tested in 109  individuals. Results showed high levels of both haplotype and nucleotide  diversity in populations corresponding to northeastern Argentina, the core  area of the species range. A strong genetic structuring was detected,  supported by both the phylogenetic trees and the haplotype network, with  six identifiable haplogroups. Populations of the Yungas ecoregion did not  show significant diversity levels, suggesting a putative recent introduction  of the species into that region. The overall results suggest that the present  genetic diversity of the species is consistent with past fragmentation  events of the species range (in refuges?), probably during the Last Glacial  Maximum. The COI gene was concluded to be a well-suited marker to  associate past environmental events with the high genetic diversity  observed in this species.","palabras_clave":"Harvestmen|Cytochrome Oxidase I|Genetic diversity.|Disjunct distribution|Neotropics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17683,"idioma_id":4,"titulo":"An approach to the study of systems of equations with GeoGebra: learning opportunities provided by the integration of CAS view: story of a workshop experience with teachers.","resumen":"Solving systems of equations at school -at least in Argentina- is usually a task that students are given as a series of techniques that ?allow? them to find a solution. How to overcome educational obstacles that are generated from a fragmented approach of knowledge? What can DGS do, in particular the CAS environment? What epistemic and instrumental value (Artigue, 2002) these techniques acquire to work with software? Do they redefine work with pencil and paper?Specifically, this paper attempts to examine a series of dynamic problems (Bifano & Villella, 2012) and study the manipulation of different parts of the same equations and reflections that have emerged from experience working with teachers who analyse and solve such problems. Using the notion of instrumental orchestration (Trouche, 2004) we considered the different types of didactical performance as a result of the workshop experience.","palabras_clave":"Systems of equations |GeoGebra|CAS view|Teachers´ workshop"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17684,"idioma_id":4,"titulo":"Experimental methods for estimation of plant fitness costs associated with herbicide-resistance genes","resumen":"In seeking to address fitness costs associated with herbicide resistance genes and alleles, it is important to start with the correct plant material. Much of the literature on the topic is of little value in addressing fitness costs because it compares populations from different locations that differ by more than the resistance alleles. Two populations from adjacentfields may have different cultural histories as well as different herbicide histories that select for different traits. Minimizing the differences between genotypes by using near-isogenic lines or by averaging the background genetics across genotypes allows the effect of the resistance trait on fitness to be more accurately identified. It is also important to match the experimental protocol to the hypothesis being tested. Frequently, fitness cost studies estimate ecological fitness by measuring biomass under glasshouse conditions. Such an experimental approach does not measure ecological fitness. Measurements of ecological fitness require the genotypes to be grown under the conditions in which they would normally grow. If the hypothesis is to address some of the components of fitness, such as biomass accumulation, then that can be done in the glasshouse. Tracking the frequency of herbicide resistance alleles over several generations provides the most accurate measure of total fitness costs. However, that approach is rarely useful in identifying the factors that contribute to the fitness cost and has to be supplemented by experiments under moredefined conditions.","palabras_clave":"Evolutionary ecology of resistance|fitness traits|resistance frequency|resistance management|target and nontarget site mutation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17685,"idioma_id":5,"titulo":"Genotipos y epidemiología de aislamientos clínicos de Cryptococcus neoformans en Corrientes, Argentina","resumen":"En esta oportunidad, presentamos y analizamos los datos de los aislamientos de origen clínico hallados entre enero del 2008 y diciembre del 2013 en el área de Micología del Laboratorio Central de Redes y Programas de la ciudad de Corrientes, distante a tan solo 20 km de Resistencia. Este laboratorio recibe muestras de los 4 hospitales de adultos y del hospital pediátrico de dicha ciudad, y constituye un centro de derivación de toda la provincia. Los aislamientos fueron genotipificados mediante PCR-RFLP del gen URA5 siguiendo el protocolo de Meyer et al. en el Departamento de Micología del Instituto de Medicina Regional de la Universidad Nacional del Nordeste. En la tabla 1 se muestran los datos recopilados. Durante el período citado, se detectaron 26 casos nuevos de criptococosis (mediana: 4 casos por ano). Los pacientes HIV positivos fueron 18 (69,2 %), lo que resulta similar a lo informado en el estudio previo en la ciudad de Resistencia, aunque menor que lo encontrado por otros autores en el país. Entre los HIV negativos, las afecciones halladas fueron diabetes mellitus, lupus eritematoso sistémico y otras inmunosupresiones. En solo un paciente se presentó una infección pulmonar de donde se recuperó el aislamiento L-814 a partir del lavado bronquial; se trataba de un veterinario que habitualmente realizaba control de plagas (murciélagos). Este enfermo estaba coinfectado con Histoplasma capsulatum (diagnóstico por serología), probablemente por exposición a una fuente de infección6. El rango etario de los pacientes fue de 26 a 67 anos. En los pacientes HIV negativos, la mediana de edad fue superior (50,5 anos), mientras que esta descendió considerablemente entre los pacientes HIV positivos (38,5 anos). La razón hombre\/mujer fue 2,6 en los pacientes HIV positivos, y 1,7, en los HIV negativos. El HIV es uno de los principales factores predisponentes de criptococosis y esta micosis oportunista está dentro de las infecciones marcadoras de sida. Con respecto a los genotipos hallados, 22 aislamientos (84,6 %) correspondieroN a C. neoformans var. grubii VNI y 2 (7,7 %) a C. neoformans var. grubii VNII. Asimismo, 2 aislamientos (7,7 %) resultaron C. neoformans híbrido VNIII (VNII-VNIV). Este híbrido también fue informado por el Estudio Multicéntrico de Criptococosis en Argentina, pero en una proporción menor, ya que en aquella investigación se informa el hallazgo de 8 de estos híbridos sobre 153 aislamientos de todo el país, mientras que en este estudio se encontraron 2 en 26 aislamientos y solo en la provincia de Corrientes. Se ha observado en los últimos tiempos un cambio en la distribución geográfica de los genotipos VNIII y VNIV, con un aumento de su prevalencia en Latinoamérica. Estos genotipos habitualmente se documentaban en el sur de Europa. No se aislaron cepas de C. gattii en esta investigación. La distribución de genotipos coincide con lo descrito a nivel mundial. Estos datos constituyen el primer informe sobre genotipos de Cryptococcus en la provincia de Corrientes y son una contribución al conocimiento de la epidemiología de la criptococosis en Argentina.","palabras_clave":"GENOTIPOS|CRIPTOCOCOSIS|VNIII"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17686,"idioma_id":4,"titulo":"Molecular detection of the human pathogenic Rickettsia sp. strain Atlantic Rainforest in Amblyomma dubitatum ticks from Argentina","resumen":"Background: To date, three tick-borne pathogenic Rickettsia species were reported in different regions of Argentina, namely, Rickettsia rickettsii, Rickettsia parkeri and Rickettsia massiliae. However, there are no reports available for the presence of tick-borne pathogens from northeastern Argentina. This study evaluated the infection with Rickettsia species in Amblyomma dubitatum ticks collected from the vegetation and feeding from capybaras (Hydrochoerus hydrochaeris) in northeastern Argentina.  Findings: From a total of 506 Amblyomma dubitatum ticks collected and evaluated by PCR for the presence of rickettsial DNA, 25 were positive for the presence of Rickettsia bellii DNA, two were positive for Rickettsia sp. strain COOPERI and one was positive for the pathogenic Rickettsia sp. strain Atlantic rainforest.  Conclusions: To our knowledge, this study is the first report of the presence of the human pathogen Rickettsia sp. strain Atlantic rainforest and Rickettsia sp. strain COOPERI in Argentina. Moreover, our findings posit A. dubitatum as a potential novel vector for this pathogenic strain of Rickettsia.","palabras_clave":"Rickettsiosis|Amblyomma dubitatum|capybara"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17687,"idioma_id":4,"titulo":"Noisy Speech Recognition based on Combined Audio-Visual Classifiers","resumen":"An isolated word speech recognition system based on audio-visual features is proposed in this paper. To enhance the recognition over different noisy conditions, this system combines three classifiers based on audio, visual and audio-visual information, respectively. The performance of the proposed recognition system is evaluated over two isolated word audio-visual databases, a public one and a database compiled by the authors of this paper. Experimental results show that the structure of the proposed system leads to significant improvements of the recognition rates through a wide range of signal-to-noise ratios.","palabras_clave":"SPEECH RECOGNITION|AUDIO-VISUAL SPEECH FEATURES|AUDIO-VISUAL INFORMATION FUSION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17688,"idioma_id":4,"titulo":"Heterogeneous photocatalytic removal of U(VI) in the presence of formic acid: U(III) formation","resumen":"The efficiency of TiO2 heterogeneous photocatalysis under UV-visible light for removal of uranyl (UO22+) (0.25 mM, pH 3) in the presence of formic acid (FA) was investigated. The effect of the counterion of the uranium salt (perchlorate and acetate-nitrate) and the use of quartz and glass photoreactors were analyzed. The transformation of U(VI) in the presence of FA was significantly high. The highest efficiency was observed for uranyl perchlorate in the quartz photoreactor with 0.001 M FA, while uranyl acetate yielded a lower removal. FA concentrations > 0.01 M provoked uranium reoxidation. U(VI) photocatalytic transformation was also studied by direct spectrophotometry using TiO2 nanoparticles in the presence of 1 M FA at pH < 2. U(V), U(IV) and U(III) were detected. U(III) formation was also apparent in the absence of photocatalyst.","palabras_clave":"PHOTOCATALYSIS HETEROGENEOUS|URANIUM (VI)|URANIUM (III)|FORMIC ACID"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17689,"idioma_id":4,"titulo":"New insights in the heterogeneous photocatalytic removal of U(VI) in aqueous solution in the presence of 2-propanol","resumen":"Abstract: The efficiency of heterogeneous photocatalysis with TiO2 under UV light (HP) for the removal of uranyl ion from water (0.25 mM, pH 3) in the presence of 2-propanol (2-PrOH) was evaluated. The effect of the counterion of the uranyl salt or anions present in the system and the use of quartz and glass photoreactors were analyzed. High U(VI) removal efficiencies were obtained, reaching 100% when starting from uranyl nitrate and 1 M 2-PrOH after 60 min in a quartz photoreactor. The reaction in the absence of 2-PrOH was rather low, reaching only around 50% in 120 min under the same conditions. The photocatalytic reaction yield was similar when the reaction started from uranyl perchlorate, but systems where acetate was present showed less removal, both in the absence and the presence of 2-PrOH. Yields with the quartz photoreactor were always higher than those with the glass reactor.  Kinetic and mechanistic analyses were performed. Comparisons with the photochemical systems in the absence of TiO2 were made. The results indicated that the uranyl nitrate system in the presence of 2-PrOH gave similar results with and without TiO2, but the other systems gave higher removal yields when TiO2 was used. The proposed mechanism suggests that U(VI)\/U(V) reduction is mediated by conduction band electrons and not by reducing organic radicals, a distinctive feature of the system. For  all studied conditions, the photocatalytic treatment allowed a better recovering of the precipitated uranium.","palabras_clave":"HETEROGENEOUS PHOTOCATALYSIS|U(VI)|U(V)|U(IV)|2-PROPANOL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17690,"idioma_id":4,"titulo":"Low temperature differentially affects tillering in spring and winter wheat in association with changes in plant carbon status","resumen":"The higher tillering potential of winter wheat cultivars as compared to spring ones has been attributed to an earlier tillering onset in the former. Tillering in grasses is known to depend on temperature and light environment, and may be mediated by plant C status. The aim of this work was to elucidate whether differences in carbohydrate accumulation between wheat types at low temperature may contribute to differences in tillering potential. A set of experiments with contrasting temperatures was conducted in both field enclosures (high irradiance, three experiments) and growth chambers (low irradiance, two experiments). The relative tiller production rate (RTR) was the highest in winter cultivars grown in cool field enclosures, and the lowest in spring cultivars in growth chambers, either cool or warm. Plant C status was inversely related to temperature the response being more pronounced in winter cultivars. Components of RTR, site filling and phyllochron, responded differently to environment and plant C status. Phyllochron increased with temperature, and was inversely correlated to sugar concentration irrespective of cultivar type. Site filling increased with irradiance in both cultivar types while sugar concentration contributed additively to its promotion solely in winter cultivars. Nevertheless, variation in site filling was larger in percentage than variation in phyllochron (200% and 41%, respectively, between most contrasting treatments). Thus, differences in tillering potential between winter and spring wheats may be attributed not only to the earlier tillering onset in the former but also to their differential response to environment and C status.","palabras_clave":"Light intensity|phyllochron|site filling|sugar signalling|temperature|tillering|Triticum aestivum L."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17691,"idioma_id":4,"titulo":"Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor &#946;","resumen":"Bi-directional crosstalk between the neuroendocrine and immune systems orchestrates immune responses in both physiologic and pathologic settings. In this study, we provide in vivo evidence of a critical role for the thyroid hormone triiodothyronine (T3) in controlling the maturation and antitumor functions of dendritic cells (DC). We used a thyroid hormone receptor (TR) &#946; mutant mouse (TR&#946;PV) to establish the relevance of the T3-TR&#946; system in vivo. In this model, TR&#946; signaling endowed DC with the ability to stimulate antigen-specific cytotoxic T-cell responses during tumor development. T3 binding to TR&#946; increased DC viability and augmented DC migration to lymph nodes. Moreover, T3 stimulated the ability of DC to cross-present antigens and to stimulate cytotoxic T cell responses. In a B16-OVA mouse model of melanoma, vaccination with T3-stimulated DC inhibited tumor growth and prolonged host survival, in part by promoting the generation of IFN-&#947;-producing CD8+ T cells. Overall, our results establish an adjuvant effect of T3-TR&#946; signaling in DC, suggesting an immediately translatable method to empower DC vaccination approaches for cancer immunotherapy.","palabras_clave":"triiodothyronine|thyroid hormone receptor &#61538;|dendritic cell|cytotoxic response|antitumor vaccination"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17692,"idioma_id":4,"titulo":"Azospirillum brasilense ameliorates the response of Arabidopsis thaliana to drought mainly via enhancement of ABA levels","resumen":"Production of phytohormones is one of the main mechanisms to explain the beneficial effects of plant growth-promoting rhizobacteria (PGPR), like Azospirillum sp. The PGPRs induce plant growth and development and they reduce stress susceptibility. However, little is known regarding the stress related phytohormone abscisic acid (ABA) produced by bacteria. We investigated the effects of Azospirillum brasilense Sp 245 strain on Arabidopsis thaliana Col-0 and aba2-1 mutant plants, evaluating the morpho-physiological and biochemical responses when watered and in drought. We used an in vitro grown system to study changes in the root volume and architecture after inoculation with Azospirillum in Arabidopsis wild type Col-0 and on the mutant aba2-1, during early growth. To examine Arabidopsis development and reproductive success as affected by the bacteria, ABA and drought, a pot experiment using Arabidopsis Col-0 plants was also carried out. A. brasilense stimulated plant biomass, increased the number of lateral roots. Azospirillum augmented photosynthetic and photoprotective pigments and retarded water loss in correlation with augmented ABA levels. Likewise, inoculation improved plants survival, seed yield, relative leaf water content, proline levels, and decreased stomatal conductance, malondialdehyde and relative soil water content in plants submitted to drought. Inoculation of Arabidopsis with A. brasilense improved plants performance, especially in drought.","palabras_clave":"Abscisic acid|Azospirillum|Plant Growth Promoting Rhizobacteria|Water restriction"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17693,"idioma_id":4,"titulo":"Involvement of PAPP-A and IGFR1 in cystic ovarian disease in cattle","resumen":"Cystic ovarian disease (COD) is one of the main causes of infertility in dairy cattle. It has been shown that intra-ovarian factors, such as members of the insulin-like growth factor (IGF) system, may contribute to follicular persistence. The bioavailability of IGF to initiate its response by binding to specific receptors (IGFRs) depends on interactions with related compounds, such as pregnancy-associated plasma protein A (PAPP-A). The aim of this study was to determine IGFR1 and PAPP-A expression both in follicles at different stages of development and in cysts, to evaluate the roles in the etiopathogenesis of COD in cattle. The mRNA expression of PAPP-A was higher in granulosa cells of large tertiary follicles than in cysts, whereas the protein PAPP-A present in the follicular fluid from these follicles showed no differences. Although no PAPP-A mRNA expression was detected in smaller tertiary follicles, in their follicular fluid, this protease was detected in lesser concentration than in cysts. The mRNA expression of IGFR1 was lower in granulosa cells from cystic follicles than in those from tertiary ones. However, the protein expression of this receptor presented the highest levels in cystic structures, probably to increase the possibility of IGF response. The data obtained would indicate that animals with COD have an altered regulation of the IGF system in the ovary, which could be involved in the pathogenesis of this disease in cattle.","palabras_clave":"cow|IGF system|COD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17694,"idioma_id":4,"titulo":"The BL-Lac gamma-ray blazar PKS 0447-439 as a probable member of a group of galaxies at z = 0.343","resumen":"Context. The BL-Lac blazar PKS 0447-439 is one of the brightest HEgamma-ray sources that were first detected by Fermi-LAT. It was alsodetected by H.E.S.S. at VHE gamma-rays, which allowed constraining theredshift of PKS 0447-439 by considering the attenuation caused bygamma-ray interactions with ambient photons in the extragalacticbackground light (EBL). This constraint agreed with color-magnitude andspectroscopic redshift constraints (0.179 &lt;z&lt; 0.56). Recently,however, a much higher redshift was proposed for this blazar (z&gt;1.2). This value was debated because if true, it would imply either thatthe relevant absorption processes of gamma-rays are not well understoodor that the EBL is dramatically different from what is believed today.This high redshift was not confirmed by three independent newspectroscopic observations at high signal-to-noise ratios. The scenariois clear evidence of the difficulties in estimating the redshift ofBL-Lac objects, whose optical spectra are typically featureless. Neitherof the estimated redshifts for PKS 0447-439 are confirmed as yet. Aims: Given that BL-Lac are typically hosted by elliptical galaxies,which in turn are associated with groups, we aim to find the host groupof galaxies of PKS 0447-439. The ultimate goal is to estimate a redshiftfor this blazar.  Methods: Spectra of twenty-one objects in thefield of view of PKS 0447-439 were obtained with the Gemini Multi-ObjectSpectrograph. Based on the redshifts and coordinates of these galaxies,we searched for groups of galaxies. Using a deep catalog of groups, westudied the probability of finding by chance a group of galaxies in theline of sight of PKS 0447-439.  Results: We identified a group ofgalaxies that was not previously cataloged at z = 0.343 with sevenmembers, a virial radius of 0.42 Mpc, and a velocity dispersion of 622km s-1. We found that the probability of the host galaxy ofPKS 0447-439 to be a member of the new group is &#8819;97%. Therefore, wepropose to adopt z = 0.343 ± 0.002 as the most likely redshiftfor PKS 0447-439.","palabras_clave":"BL lacertae|Galaxias|Espectroscopia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17695,"idioma_id":4,"titulo":"Is the balance between competition and facilitation a driver of the patch dynamics in arid vegetation mosaics?","resumen":"In most arid ecosystems, the vegetation is organized into two-phase mosaics, where high-cover vegetation patches are interspersed in a matrix of low plant cover. We studied the role of the biotic interaction balance (competition\/facilitation) between shrubs and grasses as a driver of patch dynamics and maintenance of two-phase vegetation mosaics. Following Watt?s seminal model, we conducted two field experiments in which we manipulated different vegetation patches to obtain the different stages along the building and degradation dynamics of high-cover patches. In addition we applied two possible belowground competition treatments (natural and experimentally reduced). We measured plant variables (emergence, survival, height, flower culms) on grass seedlings and transplants. We integrated all plant measurements into a single positive and negative component, to calculate the net balance along three stages of the patch dynamics proposed. The net biotic interaction balance was negative during the early and mature stages of high-cover patches because the average standardized effect from the negative component was below -0.44, while the positive component was not different from zero. However, the net biotic interaction balance was positive during the degraded stages of high-cover patches because the negative average component was -0.37, while the positive component reached 0.58. The negative net effects during early  and mature stages of high-cover patches can be explained by the occurrence of wet years, because high rainfalls hide the aboveground facilitation. Our findings point out the importance of complementary mechanisms to the interaction balance in the mosaic maintenance (e.g. trapping of seeds by shrubs) according to the inter-annual rainfall variability.","palabras_clave":"ARID STEPPES|PATCH DYNAMICS|PLANT-PLANT INTERACTIONS|TWO- PHASE VEGETATION MOSAICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17696,"idioma_id":4,"titulo":"Layered exfoliable crystalline materials based on Sm-, Eu- and Eu\/Gd- 2-phenylsuccinate frameworks. Crystal structure, topology and luminescence properties","resumen":"Three new layered metal-organic frameworks (MOFs) based on 2-phenylsuccinic acid (H2psa) and lanthanide ions with the formula [Ln2(C10H8O4)3(H2O)] (Ln = Eu, Sm and Eu-Gd) have been synthesized under solvothermal conditions and fully characterized by single-crystal X-ray diffraction, thermal and vibrational analyses. The compounds are isostructural featuring 2D frameworks that consist of infinite zigzag chains composed of [LnO8] and [LnO8(H2O)] edge-sharing polyhedra linked by psa ligands leading to layers further connected by weak &#960;-&#960; interactions in an edge orientation. Moreover, a topological study was carried out to obtain the simplified net for better comparison with structurally related compounds. The Eu-psa crystals were exfoliated into nanolayers after miniaturization by addition of sodium acetate as a capping agent in the reaction medium. Scanning electron microscopy was applied to characterize the miniaturized samples whereas the exfoliated hybrid nanosheets were studied by atomic force microscopy. The photoluminescence (PL) properties of the bulk compounds as well as the miniaturized and exfoliated materials were investigated and compared with other related ones. An exhaustive study of the Eu(iii)-based MOFs was performed on the basis of the obtained PL parameters (excitation and emission spectra, kr, knr, intrinsic quantum yields and lifetimes) to explore the underlying structure-property relationships.","palabras_clave":"Crystalline materials|Metalorganic frameworks (MOFs)|Photoluminescence properties|Atomic force microscopy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17697,"idioma_id":4,"titulo":"Dynamics of structural traits in two competing C3 grass species: influence of neighbours and nitrogen","resumen":"This work analysed the regulatory structural mechanisms involvedin the competitive interactions between the annual grass Bromus willdenowiiKunth. (BW = prairie grass) and the perennial C3 grass Dactylis glomerata L.(DG = orchardgrass) during pasture establishment. Four combinations of species(pure BW, pure DG, DG flanked by BW and BW flanked by DG plants), with andwithout winter nitrogen fertilization, were factorially arranged in arandomized complete block design. Data were recorded at two organizationlevels: tillers (three tiller age cohorts) and target plants. Annual neighbourscaused a decrease in the number of living leaves in tillers of intermediate ageof both species. This structural regulatory mechanism led to a decrease intiller number per plant and, therefore, restricted the development of horizontalspace occupation. Annual neighbours did not cause an increase in tiller size,measured as lamina length or pseudostem height, but decreased root biomass. Asa consequence, annual neighbours did not lead the hierarchy in light capture,but limited species radical colonization and competitive ability for soilresources. Winter nitrogen fertilization only affected tiller size in oldertillers. These findings emphasize the importance of the cultural decisions, assowing densities and nitrogen fertilization, to optimize pasture floristiccomposition.","palabras_clave":"BROMUS WILDENOWII|DACTYLIS GLOMERATA|PLANT COMPETITION|TILLER SIZE|TILLER DENSITY|HIERARCHIES AMONG PLANTS|PASTURE FLORISTIC COMPOSITION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17698,"idioma_id":4,"titulo":"Bone Regeneration with Wharton's Jelly-Bioceramic-Bioglass Composite","resumen":"The aim of this development is to optimize a bone substitute (BS) for use in tissue engineering. This is achieved through the combination of three phases in a biocomposite (BCO), in which each is reabsorbed in the site of implantation and replaced by autologous bone (patient´s own). The inorganic phases are composed of irregular particles (150-300 microns) obtained by milling and sieving of a biphasic bioceramic (BC) of hydroxyapatite (HA of bovine origin) with 40 % (wt.) ß-tricalcium phosphate (ß- TCP, obtained by chemical synthesis) and Bioglass type 45S5 (45SiO2 -24,5CaO - 24,5Na2O - 6P2O5, in % wt.). Instead, the organic phase consists of collagen extracted from Wharton´s jelly (part of the human embryonic tissue) from physical and chemical self-developed process. The BC is produced by mixture of HA and ß-TCP (< 45&#1049117;m) and molding by gelcasting with albumin in aqueous solutions, drying and sintering at 1200°C for 2 hours. The BG is obtained from the mixture of the oxides, melting at 1350°C and cast onto metal. Each phase and BCO is subjected to studies by electron microscopy (SEM and EDS), Xraydiffraction (DRX) and infrared spectrometry (FT-IR). The biocompatibility is evaluated by in vivo studies using the laminar implant model in Wistar rats (n=40). Histological samples show high biocompatibility and ability to integrate with the bone tissue. 30 days after implantation, the material is completely reabsorbed and the bone regeneration process starts, the primary objective. The process developed allows the synthesis of a new BS with excellent biological properties for clinical use.","palabras_clave":"Biocomposite|Tissue Engineering|Bioceramics|Bioglass"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17699,"idioma_id":4,"titulo":"Functionalization of hydroxyapatite scaffolds with ZnO","resumen":"This paper analyzes the effectiveness of a new method for treating the surface of bioceramics scaffolds intended for bone substitutes (SO). This employs hydroxyapatite (Ca5(PO4)3(OH), HA) obtained from the chemical treatment (weak acid) and pyrolysis (at 900 °C) of fresh bovine bone. The inorganic matrix is formed by an interconnected pore structure and hydrophilic, very similar to the human cancellous bone, which is used in reconstructive surgery. The SO biologic response can be improved by surface modification with Zn, element known for its antibacterial action. The Zn fixing in HA is frequently performed by chemical synthesis processes, where Zn2 +, Ca2 + and PO43&#8722; ions co-precipitation processes take place. The proposed method begins with the chemical treatment of the HA with an aqueous solution of phosphoric acid (30 wt. %). These scaffolds are submerged (under vacuum) in a dispersion of ZnO in an alcohol-glycerin solution, which allows relatively uniform distribution of oxide on the porous medium, when it is dried. The Zn chemical bonding on HA surface is accomplished by sintering (900 to 1100 °C). This promotes a solid state reaction, which leads to the formation of Zn phosphates (in hydrated and non-hydrated forms), according to the analysis of X-ray diffraction, energy spectroscopy and electron microscopy observation. This process is of simple implementation and it would allow SO functionalization with other therapeutic agents of interest, represented by different ions.","palabras_clave":"Hydroxyapatite|Bioceramic functionalization|ZnO|Bone substitutes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17700,"idioma_id":4,"titulo":"Corrosion in 316L Porous Prostheses Obtained by Gelcasting","resumen":"Gelcasting (GC) process, usually used for ceramic moulding, is adapted for producing spongy or porous metal osteosynthesiscomponents destined to bone void filling. The main objective of the interconnected porosity is to improve the osteoconductive ofmetal matrix by ingrowth of bone. Further, porosity reduces metal density and Young module, which causes bone resorption,leading to implant failure, phenomenon known as stress shielding. The employed GC is based on the formulation of AISI 316Lstainless steel powder suspension in an aqueous solution of organic polymers. This suspension is cast into porous ceramic shells,like those used in lost wax technique, wherein the polymer crosslinking is induced by heating. The shells, containing the resultinghydrogel?metal composite, are subjected to thermal cycle in order to dry, burn the organic phase, sinter the metal particles at1200 °C, and cool down to room temperature under dry hydrogen permanent flow. The susceptibility to corrosion of 50-60 %porous pieces was analyzed. The results indicated that the lower relation between the open porosity and the total porosity, thelower the corrosion rate.","palabras_clave":"Corrosion|Porous prostheses|Gelcasting"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17701,"idioma_id":4,"titulo":"A DSATUR-based algorithm for the Equitable Coloring Problem","resumen":"This paper describes a new exactalgorithm for the Equitable Coloring Problem, a coloring problem where the sizes of two arbitrary color classes differ in at most one unit.Based on the well known DSATUR algorithm for the classic Coloring Problem,a pruning criterion arising from equity constraints is proposed and analyzed.The good performance of the algorithm is shown through computationalexperiments over randomand benchmark instances.","palabras_clave":"Equitable coloring|Dsatur|Exact algorithm"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17702,"idioma_id":4,"titulo":"A PCA-based chemometrics-assisted ATR-FTIR approach for the classification of polymorphs of cimetidine. Application to physical mixtures and tablets","resumen":"The identity of the polymorphic form of an active pharmaceutical ingredient is an important parameter that may affect the performance of the drug formulation. This calls for special techniques, able to classify crystal forms or assign the polymorphic identity to a given solid in a mixture.  In order to develop a method to determine which of the relevant polymorphs of Cimetidine (CIM) is present in commercial tablet samples, authentic forms A, B, D and M1 of the drug were prepared,structurally characterized and employed as standards.  Thus, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) was coupled to Principal Component Analysis (PCA) and used for the classification of physical mixtures of CIM and excipients,as well as laboratory-made and commercial tablets, according to their polymorphic composition.  It was demonstrated that two principal components (PCs) suffice to classify the samples of the four forms of CIM into distinct groups, and that method performance is optimum when the second and third PCs are used for the classification process. The application of the method to commercial tablets of CIM also gave good results, confirming they were prepared employing the correct polymorph (form A)","palabras_clave":"CIMETIDINE|CRISTAL POLYMORPHISM|PRINCIPAL COMPONENT ANALYSIS|ATR-FTIR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17703,"idioma_id":4,"titulo":"-\tThermally Induced Solid-State Transformation of Cimetidine. A Multi-spectroscopic\/Chemometrics Determination of the Kinetics of the Process and Structural Elucidation of one of the Products as a Stable N3-Enamino Tautomer","resumen":"Exposure of  cimetidine (CIM) to dry heat (160-180ºC) afforded, upon cooling, a glassy solid  containing new and hitherto unknown products. The kinetics of this process was studied  by a second order chemometrics-assisted multi-spectroscopic approach. Proton  and carbon-13 nuclear magnetic resonance (NMR), as well as ultraviolet and  infrared spectroscopic data were jointly used, whereas multivariate curve  resolution with alternating least squares (MCR-ALS) was employed as the  chemometrics method to extract process information. It was established that  drug degradation follows a first order kinetics.      One of the  products was structurally characterized by mono- and bi-dimensional NMR  experiments. It was found to be the N3-enamino tautomer (TAU) of  CIM, resulting from the thermal isomerization of the double bond of the  cyanoguanidine moiety of the drug, from the imine form to its N3-enamine  state.  The thus generated tautomer demonstrated to be  stable for months in the glassy solid and in methanolic solutions. A  theoretical study of CIM and TAU revealed that the latter is less stable;  however, the energy barrier for tautomer interconversion is high enough, precluding  the process to proceed rapidly at room temperature. ","palabras_clave":"Cimetidine; Stable tautomeric form|MCR-ALS|NMR-CHEMOMETRICS|Multi-spectroscopic\/chemometric approach"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17704,"idioma_id":4,"titulo":"Crop loading studies with ?Caricia? and ?Eva? apples growing in a mild winter area","resumen":"The crop load level of an apple (Malus × domestica Borkh.) tree impacts fruit yield and quality parameters, tree vigor and biennial bearing. The optimal crop load is that which allows for consistent annual cropping and fruit quality acceptable to the market. We evaluated the effect of crop load on yield and fruit quality of two low-chill apples cv. ?Caricia? and ?Eva?, growing in a mild winter area. During 2010 and 2011 crop load was manually adjusted from 2 or 3 to 17 fruits cm&#8722;2 of trunk cross-sectional area (TCSA). Fruit yield was positively related to crop load in both cultivars but mean fruit weight diminished as the crop load increased. For both cultivars, the production of non-commercial and small-sized fruit increased, whereas production of middlesized fruit diminished as the fruit load increased. Shoot length was not affected by crop load in ?Eva? whereas it was reduced in ?Caricia?. Red skin color (RSC %) had a quadratic  response to crop load in ?Caricia?. On the other hand, the RSC % of ?Eva? fruit was adjusted to a negative logarithmic model as an effect of crop load increment. No biennial bearing was observed in either cultivar. This research study suggests that the maximum limit of crop load for both cultivars is 7 fruits cm&#8722;2 of TCSA, and the lower limit of crop load was 3 fruits cm&#8722;2 of TCSA for ?Eva? and 5 fruits cm&#8722;2 of TCSA for ?Caricia?.","palabras_clave":"MALUS DOMESTICA|CROP LOAD|HAND THINNING|FRUIT QUALITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17705,"idioma_id":4,"titulo":"Effect of formulation variables on rheology, texture, colour, and acceptability of apple jelly: Modelling and optimization","resumen":"The  objective was to study and model the effect of the main formulation variables  on the rheological and mechanical properties, colour and overall acceptability  of apple jelly, and to optimize formulation variables in order to maximize  overall acceptability. Formulation variables were juice proportion in the  initial juice-sugar mix (J: 350-550  g\/kg), product pH (2.8-3.6), concentration  of added pectin (P: 0-10 g\/kg), and final  content of soluble solids (SS: 625-725  g\/kg). Anova results showed that P was  the main effect on all the rheological and mechanical properties. The strength  of the pectin gel network increased at increasing values of P. Consequently, the jellies were more  elastic and firm but more brittle, as well as more adhesive. Also, more work  was required to disintegrate the jellies. Besides P, also J had a  significant positive effect on storage modulus and adhesiveness, while SS had a significant positive effect on  cohesiveness. Colour parameters were mainly affected by J. Overall acceptability was significantly affected by J > pH > SS, while P had no significant effect. The optimum  was calculated to be at J = 500 g\/kg,  SS = 700 g\/kg, pH = 3.4, and P = 5 g\/kg.","palabras_clave":"FRUIT JAMS|COMPOSITION|GELIFICATION|STRUCTURE|SENSORY EVALUATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17706,"idioma_id":4,"titulo":"University Postgraduate Programs and Their Evaluation - Comparative Aspects between Argentina, Brazil and Uruguay","resumen":"This paper analyzes the research policies adopted in universities and their evaluation, comparing aspects between Argentina, Brazil and Uruguay. The study encompasses diverse documents on current regulations, impact assessments and interviews to key persons. The comparison allows for identifying, among the common aspects, the difficulties for developing a quality evaluation process, considering the diversity of systems in higher education, being heterogeneous in the three countries. There exist differences related to the origin and consolidation of the systems evaluating university quality and science and technology, the policies developed at the different stages and the influence of the political and economic context. These aspects exert great influence on the different ways to evaluate the research function, among the national cases as well as regarding their inner characteristics.","palabras_clave":"HIGHER EDUCATION|RESEARCH FUNCTION|SCIENCE AND TECHNOLOGY QUALITY EVALUATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17707,"idioma_id":4,"titulo":"Effects of androgen deprivation in rat lung: oxidative stress and citoprotective parameters","resumen":"Abstract: The aim was to study the effect of androgen deprivation, focusing on oxidative stress, and  cytoprotective markers, in order to better understand the possible causes of pulmonary diseases in elder  people.  Adult male Wistar rats were divided into three groups: control (Co), a group subjected to castration by  simple orchidectomy (Ca) and a group subjected to orchidectomy that received testosterone (100 µg\/kg  body weight) daily from day 25 to day 30 after castration (Ca + T). Bronchoalveolar lavages (BAL) and  lungs were obtained.  We observed a decrease in body weight in the castrated groups. Protein content in BAL was increased in  both castrated groups while nitrites did not show differences among the groups. TBARS, Catalase (CAT)  and Glutathione Peroxidase (GPx) activities were significantly increased in the castrated group, returning  to the control values after the administration of testosterone. AR expression was increased in the castrated  groups. Nrf-2 factor was increased in both castrated groups, while NADPH oxidase (NOX) and GPx  expression increased in the Ca group but showed a decrease to control values in the Ca+T group.  Superoxide Dismutase (SOD) did not show differences among the treatments. The immunohistochemistry  showed a decreased expression of Hsp27 and increased expression of Hsp70  The absence of androgens induces oxidative stress in lung, together with changes in the expression of  cytoprotective markers. This would lead to weak lung stroma, susceptible to undergo several pulmonary  diseases.","palabras_clave":"CYTOPROTECTIVE MECHANISM|CASTRATION|LUNG"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17708,"idioma_id":4,"titulo":"Detection of Orthobunyavirus in mosquitoes collected in Argentina","resumen":"Bunyamwera virus (BUNV) (Bunyaviridae, genus Orthobunyavirus, serogroup Bunyamwera) is considered an emerging pathogen for humans and animals in American countries. The CbaAr-426 strain of BUNV was recovered from mosquitoes Ochlerotatus albifasciatus (Diptera: Culicidae) collected in Córdoba province (Argentina), where serological studies detected high seroprevalences in humans and animals. Molecular detection of Orthobunyavirus was performed in mosquitoes collected in Córdoba province. Seventeen mosquito pools of Oc.&#8201;albifasciatus, Ochlerotatus scapularis and Culex quinquefasciatus (Diptera: Culicidae) showed positive results; four of these positive pools, all of Oc.&#8201;scapularis, were sequenced. All amplicons grouped with BUNV in the Bunyamwera serogroup. The findings highlight the circulation of BUNV in Córdoba province and represent the first report of BUNV-infected Oc.&#8201;scapularis mosquitoes in Argentina.","palabras_clave":"Bunyamwera|Orthobunyavius|CbaAr-426 strain|Ochlerotatus albifasciatus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17709,"idioma_id":5,"titulo":"Sistemas socio-técnicos de producción e innovación. Análisis de la dinámica del sector de producción de carne aviar en la Argentina","resumen":"El artículo expone los resultados del análisis de la dinámica del   sistema socio-técnico de producción e innovación de carne aviar en   Argentina. A partir de un marco analítico?conceptual convergente, con   aportes de las trayectorias de estudios sociales de la tecnología y de   la economía evolucionista neo-schumpeteriana orientada a sistemas   complejos, el estudio se focaliza en analizar la evolución histórica del   sistema. Para esto utiliza aportes de la Teoría del Actor Red (TAR) y   del análisis estadístico de social network. Las conclusiones expresan   cuestiones teóricas y políticas. En cuanto a las cuestiones teóricas,   evidencia las posibilidades de convergencias entre los aportes de ambas   trayectorias académicas del campo latinoamericano de Ciencia, Tecnología   y Sociedad (CTS). Desde el punto de vista político, permite efectuar un   análisis crítico sobre las redes tecno-económicas y sociopolíticas   implícitas en el desarrollo del polo de producción de carne aviar en   Argentina, sus limitaciones y desafíos para renovadas políticas de   ciencia y tecnología en el sector.","palabras_clave":"SISTEMAS SOCIOTÉCNICOS DE PRODUCCIÓN|INNOVACIÓN|MARCO TEÓRICO CONVERGENTE|CARNE AVIAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17710,"idioma_id":4,"titulo":"Photoinduced Charge Separation in Organic - Organic Heterojunctions Based on Porphyrin Electropolymers. Spectral and Time Dependent Surface Photovoltage Study","resumen":"Photoactive heterojunctions formed by porphyrin polymers were electrochemically generated and analyzed by both transient and spectral dependent surface photovoltage. Indium tin oxide\/organic polymer heterojunction photovoltages showed to be dependent on the presence of Zn (II) as central metal on the porphyrin polymer structure. The porphyrin electropolymers were also successfully formed on the top of a poly 3,4-ethylenedioxythiophene layer, generated by electropolymerization. The presence of the hole transport polymer dramatically altered the formation and diffusion process of the photocarriers created by excitation of the porphyrin films. A marked increase in the generated photovoltages was observed when the porphyrin electropolymer external surfaces were modified with a layer of a strong electron acceptor (C60 buckminsterfullerene), showing that these heterojunctions could be used in the development of new solar energy technologies.","palabras_clave":"Tetrapirrolic Compounds|Surface Photovoltage|Conducting Polymers|PEDOT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17711,"idioma_id":4,"titulo":"Evaluation of the Nutritional Quality of the Grain Protein of New Amaranths Varieties","resumen":"The efforts for promoting the consumption of food of plant origin are increasingly growing. The amaranth grain is an important vegetable protein source, superior in content and quality to traditional cereals. In the central-west region of Argentina, new amaranth varieties have been obtained to optimize its agronomic traits and promote its use. In this work, the analysis of the wholemeal flour protein from seeds of two new varieties of Amaranthus cruentus var. Candil (CC) and Amaranthus hypochondriacus var. Dorado (HD), as well as from advanced lines of Amaranthus hypochondriacus x Amaranthus cruentus H17a (H17) and Amaranthus cruentus G6\/17a (CG6), was carried out in order to elucidate their nutritional contribution to human diet. The amino acids profile and the chemical score (CS) were determined, and the protein quality was evaluated in-vivo through the following indexes: net protein utilization (NPU), true digestibility (tD), biological value (BV) and protein digestibility corrected amino acid score (PDCAAS). In general, the amino acids values of the different varieties exceeded the requirements established by the WHO\/FAO\/UNU; however, valine was the limiting amino acid in all cases. The values obtained (%) were within the following ranges: NPU, 33.56?46.04 %; tD, 68.80?75.40 %; BV, 44.53?64.28%; and PDCAAS, 23.69?36.19 %. These results suggest that the new amaranth flours varieties can be adequate for human consumption and as complementary protein source.","palabras_clave":"AMARANTHS|CHEMICAL SCORE|NET PROTEIN|UTILIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17712,"idioma_id":4,"titulo":"Responses of olive tree yield determinants and components to shading during potentially critical phenological phases","resumen":"Shading for short periods during potentially critical phenological phases can improve our understanding of the processes underlying the reductions in crop performance when solar radiation is limiting in high density orchards. Our objective was to evaluate the effects of three separate 30 day-long shade periods imposed during fruit set (FS), endocarp sclerification (ES), and early oil accumulation (OA) on some oil yield determinants and components in olive. Four shading levels (3, 20, 40, and 70% of incident photosynthetically active radiation; PAR) were applied in each period using shade cloths that surrounded one-half of large individual trees. Individual fruit dry weight, oil concentration (%) on a dry weight basis, and non-fruiting branch growth were determined at the end of each shading period, 45 days after their completion, and at the end of the season. The previously shaded- and the unshaded-halves of each tree were also harvested at the end of the season to obtain fruit number and oil yield for each half-tree. Individual fruit dry weight and oil concentration at the end of all three shading periods were decreased by shading due to reduced absolute rates of fruit growth and oil accumulation, respectively. However, at final harvest, there were no statistically significant treatment differences in individual fruit weight. By contrast, a small reduction in oil concentration persisted in the fruit from trees subjected to heavy shading during the OA period. Oil yield per half-tree at end of the season was decreased by shading applied during FS and OA periods, principally due to decreases in fruit number and oil concentration, respectively. Final oil yield was not affected by shading during the ES period. Elongation of non-fruiting branches was only decreased by shading during the early spring FS period, when vegetative growth was somewhat more sensitive to shading than fruit growth. Lastly, no consistent response of return bloom to the shading periods was detected the following spring. Our results suggest that the FS period when fruit number is defined and the OA period are more critical for determining final oil yield than the ES period. This information could provide guidance for the design of more effective management strategies in high density orchards where shading can play a key role.","palabras_clave":"Fruit number|Fruit weight|Oil concentration| Photosynthetically active radiation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17713,"idioma_id":4,"titulo":"Study of the natural resource and economic feasibility of the production and delivery of wind hydrogen in the province of Córdoba, Argentina","resumen":"The wind map of the province of Cordoba, Argentina is improved starting from new wind measurements of ten meteorological stations installed in the province, whose equipment meets international standards for wind measurements. This correction is made on the basis of GIS Ordinary Cokriging interpolation method along with other wind global data basis. From the new wind GIS, a map of potential for annual production of electrolytic hydrogen from wind energy is performed and the required demand for generating mixtures of hydrogen to 20% V\/V with natural gas, within CNG stations, is calculated. This clean alternative fuel is proposed as a hybrid technology for progressive transition to a hydrogen economy in Cordoba, and in Argentina. Hydrogen delivery costs are estimated considering gas modules transported by trucks taking into account optimization of routes solving numerically the capacitated vehicle routing problem. The total cost for hydrogen including production and delivery is estimated to be 9.41 USD\/kg H2.","palabras_clave":"Wind energy|Hydrogen|GIS|Hydrogen delivery|Cost estimation|VRP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17714,"idioma_id":5,"titulo":"Enteritis granulomatosa en caninos. Reporte de un caso","resumen":"Se presenta el caso de una hembra canina de raza indefinida con síntomas de diarrea crónica a la que se le diagnóstico una enteritis granulomatosa crónica por medio de histopatología. Este estudio describe los hallazgos ecográficos observados.","palabras_clave":"CANINO|ULTRASONOGRAFÍA|GRANULOMA|ENTERITIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17715,"idioma_id":4,"titulo":"Karyotypes of some species of the genus Lessingianthus  (Vernonieae, Asteraceae) and taxonomic implications","resumen":"We determined the karyotypes of nine species of Lessingianthus, eight of which are here analyzed for the frst time. Te   results  include the frst chromosome count for L. plantaginoides, which  is tetraploid with 2n=64. All species showed a   high proportion of metacentric chromosomes combined with a lower proportion of submetacentric pairs. Only L. coriaceus   had a  subtelocentric chromosome pair. B chromosomes were observed  in L.  coriaceus and L. varroniifolius, which were   subtelocentric. Diferences among  the karyotypes of  the  studied  species were  small,  suggesting  that karyotype diversity   in the genus evolved by small changes in the structure of chromosomes. Karyotype features appear useful to distinguish   Lessingianthus from the closely related genera Chrysolaena and Lepidaploa.","palabras_clave":"ASTERACEAE|KARYOTPES|TAXONOMY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17717,"idioma_id":4,"titulo":"Research on implants and osseointegration","resumen":"Osseointegration was originally defined as a direct structural and functional connection between ordered living bone and the surface of a load-carrying implant.  It is now said that an implant is regarded as osseointegrated when there is no progressive relative movement between the implant and the bone with which it is in direct contact.  Although the term osseointegration was initially used with reference to titanium metallic implants, the concept is currently applied to all biomaterials that have the ability to osseointegrate. Biomaterials are closely related to the mechanism of osseointegration; these materials are designed to be implanted or incorporated into the living system with the aims to substitute for, or regenerate tissues and tissue functions. Objective evaluation of the properties of the different biomaterials and of the factors that influence bone repair in general, and at the bone tissue-implant interface, is essential to the clinical success of an implant. The Biomaterials Laboratory of the Oral Pathology Department of the School of Dentistry of the University of Buenos Aires is devoted to the study and research of the properties and biological effects of biomaterials for dental implants and bone substitutes. The present report summarizes the research works resulting from over 25 years experience in this field. They include studies conducted at our laboratory on the local and systemic factors affecting the peri-implant bone healing process, using experimental models developed by our research team. The results of our research on corrosion, focusing on dental implants, as well as our experience in the evaluation of failed dental implants and bone biopsies obtained following maxillary sinus floor augmentation with bone substitutes, are also reported.   Research on biomaterials and their interaction with the biological system is a continuing challenge in biomedicine, which aims to achieve optimal biocompatibility and thus contribute to patient health.","palabras_clave":"BIOMATERIALS|OSSEOINTEGRATION|PERI-IMPLANT BONE HEALING|BONE SUBSTITUTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17718,"idioma_id":4,"titulo":"Draft Genome Sequence of a Taxonomically Unique Acinetobacter Clinical Strain with Proteolytic and Hemolytic Activities","resumen":"        Acinetobacter sp. strain A47, which has been recovered from several soft tissue samples from a patient undergoing reconstructive        surgery due to a traumatic amputation, was categorized as a taxonomically unique bacterial strain. The molecular analysis based        on three housekeeping protein-coding genes (16S rRNA, rpoB, and gyrB) showed that strain A47 does not belong to any of the        hitherto known taxa and may represent a previously undescribed Acinetobacter species.","palabras_clave":"GENOME|SEQUENCE|UNIQUE|ACINETOBACTER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17719,"idioma_id":4,"titulo":"Biostratigraphy and palaeoecology of Middle-Late Ordovician conodont and graptolite faunas of the Las Chacritas River section, Precordillera of San Juan, Argentina","resumen":"A conodont-graptolite biostratigraphic study was carried out on the top strata of  the San Juan, Las Chacritas and Las Aguaditas formations in the La Trampa Range,  Precordillera of San Juan in western Argentina. Significant conodont records in the San Juan  and Las Chacritas formations allows for the recognition of the Yangtzeplacognathus crassus,  Eoplacognathus pseudoplanus (Microzarkodina hagetiana and M. ozarkodella subzones) and  Eoplacognathus suecicus zones of Darriwilian age. Index species and co-occurrences of  graptolites and conodonts were recorded in the Las Aguaditas Formation allowing the  identification of the Nemagraptus gracilis and the Pygodus anserinus zones, which represent the Sandbian Stage. These data indicate a hiatus between the Las Chacritas and the Las  Aguaditas formations, corresponding to the Pygodus serra Zone and the Pterograptus elegans  and Hustedograptus teretiusculus zones (upper Darriwilian). A total of 7,287 identifiable  conodont elements were recorded from the study section. The species frequency registered for  each zone shows that Periodon and Paroistodus are the most abundant taxa, which are  indicative of open marine environments. The records of particular conodont taxa, such as  Histiodella, Periodon, Microzarkodina, Eoplacognathus and Baltoniodus, allow a precise  global correlation with other regions, such as south-central China, Baltoscandia, North  America, Great Britain, Southern Australia and New Zealand. The graptolite fauna identified  herein can be recognized worldwide in equivalent strata in the Baltic region, Great Britain,  North America, China, southern Australia and New Zealand. The presence of graptolites in  the ribbon limestones of the Las Chacritas Formation is documented for the first time.","palabras_clave":"conodonts|graptolites|biostratigraphy|palaeoecology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17720,"idioma_id":4,"titulo":"Thermodynamic model for biomass processing in pressure intensified technologies","resumen":"Pressure intensified technologies have a great potential in the context of biomass refining. A thermodynamic model able to predict phase behavior of typical mixtures found in biomass processing technologies, containing for instance hydrocarbons, organo-oxygenated compounds and water, is required for the development of a biorefinery process simulator. Moreover, the design of particular fuel\/biofuel blends also requires the support of a thermodynamic model to predict the properties of the final products. These types of mixtures are highly non-ideal due to the presence of association and solvation effects. It has already been proved that the Group Contribution with Association Equation of State (GCA-EoS) is able to predict the complex phase behavior of mixtures containing natural products and biofuels. In the last few years, several contributions agree that 2,5-dimethylfuran has a great potential as a sugar-derived fuel additive. In this work, as a case study, we extend the GCA-EoS to represent the phase equilibria of furan derivatives with hydrocarbons and alcohols. In addition, we show that the GCA-EoS is able to predict, based on the performed parameterization, high pressure data of 2,5-hydroxymethylfurfural solubility in CO2 and ethanol as co-solvent.","palabras_clave":"BIOREFINERY|TERMODYNAMICS|PRESSURE INTENSIFIED PROCESS|GCA-EOS|BIOMASS UPGRADE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17721,"idioma_id":4,"titulo":"Mating success at high temperature in highland- and lowland-derived populations as well as in heat knock-down selected Drosophila buzzatii","resumen":"Thermal-stress selection can affectmultiple fitness components including mating success. Reproductive success is one of the most inclusive measures of overall fitness, and mating success is a major component of reproduction. However, almost no attention has been spent to test howmating success can be affected by thermal-stress selection. In this study, we examine the mating success in the cactophilic Drosophila buzzatii Patterson & Wheeler (Diptera: Drosophilidae) derived from two natural populations that nearly represent the ends of an altitudinal cline for heat knock-down resistance. Furthermore, we extended the analysis using laboratory lines artificially selected for high and low heat knock-down resistance. Mating success at high temperature was found to be higher in the lowland than the highland population after a heat pre-treatment. Moreover, individuals selected for heat knock-down resistance showed higher mating success at high temperature than did individuals selected for low knock-down resistance. These results indicate that adaptation to thermal stress can confer an advantage on fitness-related traits including mating success and highlight the benefits of earlier heat exposure as an adaptive plastic response affecting mating success under stress of higher temperature.","palabras_clave":"COPULATORY SUCCESS|HEAT-STRESS SELECTION|HEAT PRE-TREATMENT|THERMAL ADAPTATION|DROSIPHILIDAE|DIPTERA|KNOCK-DOWN RESISTANCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17723,"idioma_id":4,"titulo":"Growth hormone (GH)\/STAT5 signaling during the growth period in liver of mice overexpressing GH","resumen":"Growth hormone (GH)\/STAT5 signaling is desensitized in liver of adult   transgenic mice overexpressing GH; however, these animals present   greater body size. To assess if the STAT5 pathway is active during the   growth period in the liver of these animals, and how signaling   modulators participate in this process, growing transgenic mice and   normal siblings were evaluated. STAT5 does not respond to an acute   GH-stimulus but presents higher basal phosphorylation in liver of   growing GH-overexpressing mice. GH receptor and positive modulators GR   and HNF1 display greater abundance in transgenic animals, supporting   STAT5 activity. Negative modulators CIS and PTP1B are increased in   GH-overexpressing mice. Suppressors SOCS2 and SOCS3 exhibit higher mRNA   levels in transgenic mice but lower protein content, suggesting they are   being degraded. Therefore, STAT5 signaling is increased in liver of   GH-transgenic mice during the growth period, with a balance between   positive and negative effectors resulting in an accelerated but   controlled growth.","palabras_clave":"GH|LIVER|STAT5|GROWTH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17724,"idioma_id":4,"titulo":"High Altitude Solar UV-B and Abscisic Acid Sprays Increase Grape Berry Antioxidant Capacity","resumen":"Abstract: It has been proposed that ultraviolet-B (UV-B) radiation activates the antioxidant defense system in  grapevines and that abscisic acid (ABA) acts downstream in the signaling pathway. Here, we studied the effects  of solar UV-B and ABA sprays on berry quality indicators and fruit yield in Vitis vinifera L. cv. Malbec grown  in a high-altitude vineyard, for five developmental stages and three growing seasons. Grapevines were exposed to  elevated ambient solar UV-B (+UV-B) or to UV-B-filtered sunlight (?UV-B) from 15 days before flowering, combined  with weekly sprays of 1 mM ABA (+ABA) or water (?ABA) from 27 days before veraison. The concentration  of phenols (anthocyanins and total polyphenols) in berry skin was increased by +UV-B and +ABA, and there was  a significant interaction between UV-B and ABA. For a given increase in sugar content, antioxidant capacity and  phenolic contents were higher in berries in the +UV-B\/+ABA treatment than in berries in the ?UV-B\/?ABA treatment.  +UV-B and +ABA interacted to lessen the number of berries, possibly because of higher ethylene emissions,  and additively reduced cluster weight without affecting sugar concentration at harvest. Antioxidant compounds,  which are protective for plants, were triggered by +UV-B\/+ABA at the expense of sugar accumulation, berry retention,  and growth (fruit yield). Effects of UV-B and ABA on sugar accumulation and berry growth were dependent  on the developmental stage. In high-altitude vineyards, solar UV-B and ABA application interact to increase quality  indicators in red grape berries. The effects of UV-B and ABA on berry quality indicators are significant on a  concentration basis (important from a winemaking standpoint) and additive on a per-berry basis.  Key words: ABA, ethylene, ORAC, phenols, UV-B, Vitis vinifera L.","palabras_clave":"ABA|ETHYLENE|ORAC|PHENOLS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17725,"idioma_id":4,"titulo":"Impact of Ligustrum lucidum on the soil seed bank in invaded subtropical seasonally dry woodlands (Córdoba, Argentina)","resumen":"The impact of invasive species on belowground flora may differ from that on the above groundvegetation. Recent reviews of invaded and nativecommunities emphasize the need for more comprehensiveinformation on the impacts of plant invasionon soil seed banks. Ligustrum lucidum is one of themost important invasive woody species in severalecosystems of Argentina; however, its impact on soilseed bank communities has not been studied. Here weanalyzed differences in species richness, total seeddensity and species composition (total, native andexotic species) in the soil seed bank of native andinvaded woodlands, in two different seasons. We alsoanalyzed differences in similarity between standingvegetation and soil seed banks of both woodland types.The study was carried out in the Chaco Serranowoodlands of Co´rdoba, central Argentina. Our mainresults indicate differences in L. lucidum woodlandcomposition and a reduction in both richness and totaldensity of species in the soil seed bank compared to thenative woodlands, independently of the samplingseason. Moreover, a higher abundance of certainexotic species in the soil seed bank was observed in L.lucidum woodlands, particularly in spring. Finally,low similarity between soil seed bank and the establishedvegetation was observed in both woodlandtypes. From a management perspective, it seems thatpassive restoration from soil seed banks of L. lucidummight be coupled with active addition of some nativewoody species and control of other exotic species","palabras_clave":"ALIEN SPECIES|EXOTIC SPECIES|SOIL SEED BANK|WOODY INVASION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17726,"idioma_id":5,"titulo":"Determinación de Trichinella spp. en jabalí (Sus scrofa)","resumen":"La trichinelosis es una zoonosis causada por nematodes del género Trichinella.  Este parásito está ampliamente distribuido por todo el mundo y afecta tanto a  animales domésticos como salvajes de todos los continentes. En nuestro país se ha  identificado T. spiralis en armadillos, jabalíes y pumas; T. patagoniensis en puma y  T. pseudospiralis en cerdo doméstico. Se analizaron 109 muestras de músculo, 89  fueron obtenidas de jabalíes adultos y 20 de cruzas de jabalí x cerdo doméstico  criados en estado salvaje mediante digestión artificial. Todas las muestras  resultaron negativas. Hay que tener presente a la fauna sinantrópica, oficia de nexo  entre los animales domésticos y los salvajes y no sabemos si albergan al parásito  en sus músculos. El consumo de carnes de caza muchas veces en preparaciones  que no requieren cocción, sumado a que en ocasiones se hace un inadecuado  manejo de los despojos, dejando carcasas con restos de carne, en el medio  ambiente a merced de animales carroñeros, incrementa el riesgo de transmisión del  parásito a los seres humanos.","palabras_clave":"TRICHINELLA SPP|DIAGNOSTICO|SUS SCROFA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17727,"idioma_id":4,"titulo":"Structural and functional responses of the oligochaete and aeolosomatid assemblage in lowland streams: a one-way-pollution-modelled ecosystem","resumen":"We investigated the responses of the assemblage of Oligochaeta and Aeolosomatidae to organic pollution; comparing taxonomic richness, diversity, abundance, and diet of the individuals inhabiting two lowland streams with different degrees of anthropic impact (the Rodríguez and the Carnaval) belonging to the Río de la Plata basin, Argentina. The physicochemical parameters in the Rodríguez Stream indicated a strong deterioration of the water quality compared to that of the Carnaval. A canonical-correlation analysis indicated that the Tubificinae, Megadrili, Enchytraeidae, and Rhyacodrilinae were more closely associated with the Rodríguez Stream; whereas the Naidinae, Pristininae, and Opystocystidae were more highly represented in the Carnaval. The diversity and taxonomic richness in the Rodríguez Stream exhibited significant differences from those of the Carnaval (p<0.001), but the abundance was not different between the two sites. Schoener?s index revealed the higher degree of dietary overlap of the two streams because all the species analyzed consumed a high proportion of detritus, especially the organisms in the Rodríguez. In the Carnaval Stream a higher number of alimentary items were consumed, and mainly by the Naidinae. This difference?probably reflecting the greater availability of this resource at sites impacted by organic pollution?underscores the fundamental role of oligochaetes in the food webs of aquatic ecosystems. The combined use of structural and functional parameters enables a more comprehensive view of how these lotic systems function and as such provides information that will serve to design tools for the management of such temperate environments.","palabras_clave":"OLIGOCHAETA|LOWLAND STREAM|ORGANIC POLLUTION|DIET"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17728,"idioma_id":4,"titulo":"Effects of past and future land conversions on forest connectivity in the Argentine Chaco","resumen":"Land-use change is a main driver of habitat loss and fragmentation worldwide. The South American Chaco has among the highest rates of dry forest loss in the world, mainly due to the expansion of soybean production and cattle ranching, yet the effects of past deforestation on landscape connectivity remain unclear. Argentina recently implemented a national zoning plan (i.e., the Forest Law) to reduce further forest loss. However, it is unclear how the implementation of the Forest Law will affect forest connectivity in the Chaco. We studied changes in the extent, fragmentation, and connectivity of natural forests between 1977 and 2010, by combining agricultural expansion and forest cover maps, and for the future in a scenario analysis. Past agricultural expansion translated into an overall loss of 26% of the Argentine Chaco´s forests, with deforestation rates in 2000-2010 up to three times higher than in the 1980s. Our results suggest that forest fragmentation and connectivity loss were highest in 1977-1992, when road construction fragmented large forest patches. Our future scenario analysis showed that if the Forest Law was implemented as planned, forest area and connectivity in the region would decline drastically. Land-use planning  designed to protect stepping stones could substantially mitigate these trends, with the co-benefit of preserving the greatest amount of biodiversity priority areas across all evaluated scenarios. Including scenario analyses that assess forest fragmentation and connectivity at the ecoregion scale is thus important in upcoming revisions of the Argentine Forest Law, and, more generally, in debates about sustainable resource use.","palabras_clave":"AGRICULTURE EXPANSION|ECOREGION|DRY FORESTS|CONSERVATION PLANNING|FOREST FRAGMENTATION|FUTURE SCENARIOS|NATIONAL FOREST LAW|PROTECTED AREAS|STEPPING STONES|SUBTROPICAL DEFORESTATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17729,"idioma_id":4,"titulo":"Ecosystem impacts of the invasive bivalve Limnoperna fortunei (golden mussel) in South America","resumen":"We summarize current knowledge on the effects of the invasive Asian bivalve Limnoperna fortunei (introduced in South America around 1990) on local biota. Limnoperna modifies nutrient concentrations and decreases concentrations of particulate organic matter in the water-column (including phytoplankton and zooplankton), thus enhancing light penetration and stimulating growth of periphyton and macrophytes. Selective grazing and modification of the N:P ratio are responsible for strong enhancements of toxic cyanobacterial blooms. Limnoperna beds significantly enhance the numbers, biomass and diversity of practically all accompanying invertebrates. The mussel´s planktonic larvae represent an important food item for the larvae of 18 fish species, while juveniles and adults are consumed by at least 50 fish species. Limnoperna is the first and only abundant benthic filter-feeding animal in South American continental waters. The fact that it intercepts and retains in the freshwater lotic domain particulate organic matter that would otherwise be swept into the sea must represent an important energetic subsidy, but the ecosystem-wide consequences of this trophic shift have not yet been addressed. Comparison with the impacts of the zebra mussel in Europe and North America suggest important differences.","palabras_clave":"LIMNOPERNA FORTUNEI|ENVIRONMENTAL IMPACT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17730,"idioma_id":5,"titulo":"La complejidad social en Aguada. El caso del Valle de Antinaco, Departamento de Famatina, Norte de la Provincia de La Rioja (Argentina)","resumen":"Apartir del desarrollo del fenómeno Aguada durante el Período Medio claramentetuvo lugar un&nbsp; proceso complejizaciónsocial en la región Valliserrana que, de acuerdo a los procesos históricosparticulares, se manifestó con características específicas en cada zona, locual favoreció la construcción de identidades locales. En todos los ámbitos dela región se evidencia: a) un aumento poblacional que se traduce en&nbsp; la cantidad,&nbsp;escala y funcionalidad de los sitios; b) la presencia de un patrón deinstalación jerarquizado, tanto en el tamaño como en la estructuración internade los asentamientos; y c) el uso de un repertorio iconográfico vinculado acierta ideología religiosa. Atendiendo a estas evidencias, se realizan algunasconsideraciones generales sobre la complejidad y los modos de organizaciónsocial de las sociedades que formaron parte de éste fenómeno y,específicamente, sobre las que habitaron en el Valle de Antinaco, en el nortede la provincia de La Rioja. Se parte de la idea de que lospaisajes son el resultado de la representación que cada comunidad hizo deellos, y que los&nbsp; monumentos y el ritualasociado tuvieron una vital significación en la creación y reproducción de la autoridadde aquellos individuos instruidos en sus saberes. De acuerdo con esto, seanaliza la trazaarquitectónica del sitio La Cuestecilla y de las Aldeas circundantes, haciendo referenciatambién a&nbsp; otras materialidadesrecuperadas&nbsp; en los sitios intervenidos.","palabras_clave":"AGUADA|IDEOLOGÍA RELIGIOSA|COMPLEJIDAD SOCIAL|MODOS DE ORGANIZACIÓN SOCIAL|VALLE DE ANTINACO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17731,"idioma_id":4,"titulo":"Design of devices and manufacturing of Fe-Mn-Si shape memory alloy couplings","resumen":"              We  have studied an Fe-15Mn-5Si-9Cr-5Ni (wt.%) shape memory alloy produced by  casting in sand moulds. After processing by rolling at 800° C followed by  annealing at 650° C, the structure contains a high density of stacking faults  and high strength austenite. When a stress is applied to the material, a  reversible martensitic transformation activates before the austenite deforms  plastically. Under these conditions, the material recovers about 95% of a 3%  permanent deformation. The mechanical properties were measured by tensile  tests, giving a yield strength of 350 MPa, an ultimate strength of 880 MPa and  16% total elongation to fracture. Furthermore, the alloy has good weldability  using the GTAW method. No macro or micro defects were observed, but there is a  15% deterioration of the shape memory properties due to a heat affected (HAZ)  and welded zone (WZ), as measured with bend specimens. In this work, we studied  the formability of the material, finding very good performance in simple  bending tests. We also present a method for manufacturing couplings by forming  and welding, designing forming devices and obtaining the first prototypes.  Finally, we evaluated the shape memory properties of the manufactured  couplings, finding 83% recovery of a 3.6% diameter expansion. This amount of  recovery is suitable for various industrial applications.  ","palabras_clave":"Shape memory|martensite|texture|manufacturing processes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17732,"idioma_id":4,"titulo":"Ultrasonic Lamb waves detection using an unstabilized optical interferometer with uncalibrated phase shifts","resumen":"We present an experimental and post-processing scheme that allows ultrasound surface wave detection by means of an unstabilized homodyne interferometric technique. We register interference signals for a set of uncalibrated phase shifts and, from them, we are able to retrieve the normal surface displacement of a thin aluminium plate. The results obtained with this technique are then compared to robust and more traditional phase recovery methods such as the Carré algorithm and the 11-step windowed discrete Fourier transform algorithm. For both algorithms, we found a correlation superior to 99.9%, when compared to the results of the proposed technique. This non-destructive testing scheme represents a simpler and less-expensive alternative to other existing laser ultrasonic techniques.","palabras_clave":"PHASE SHIFT|INTERFEROMETRY|SURFACE WAVES|LASER ULTRSONICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17733,"idioma_id":4,"titulo":"Birefringent phase demodulator: application to wave plate characterization","resumen":"The scope of this work is to present a phase demodulator that enables the recovery of temporal phase information contained in the phase difference between two signals with different polarizations. This demodulator is a polarization interferometer which may consist only of a uniaxial crystal slab and a polarizer sheet. The phase shift between two orthogonal components of the electric field is translated into space by means of birefringent crystals, which act as demodulators or phase analyzers with great robustness. The experimental scheme utilized is based on a simple conoscopic interference setup. Each portion of the space where the interference pattern is projected contains not only the unknown temporal phase we want to recover, but also a phase shift due to the uniaxial crystal itself. The underlying idea is developing simultaneous phase shifting with uniaxial crystals. Thus, different phase recovery techniques can be applied in order to maximize their ability to track high speed signals. Depending on the characteristics of the fringe pattern it will permit phase recovery via different classical procedures. In order to prove the demodulator under different experimental and signal processing schemes, we employed it for wave plate characterization. The results obtained do not only allow some wave plate features such as axes determination and retardance to be characterized,  but also prove the working principle and capabilities of the demodulator.","palabras_clave":"Fringe analysis|Interferometry|Phase measurement|Polarization-selective devices|Crystal optics|Birefringence"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17734,"idioma_id":4,"titulo":"A versatile Carberry-type microcatalytic reactor for transient and\/or continuous flow operation at atmospheric or medium pressure","resumen":"A novel catalytic reaction device featuring a Carberry-type well-mixed microreactor built inside a medium pressure leak valve is presented. The complete reaction system allows a broad range of kinetic reaction engineering and heterogeneous catalysis studies for both batch (transient) and continuous operation. Carefully controlled temperature (± 0.2 K) and pressure (up to 3 MPa) conditions can be achieved. The continuous sampling of the reacting mixture permits instantaneous evaluation of the gas phase composition.  The device performance was validated by comparing methanol synthesis reaction rates for H2\/CO2 mixtures obtained under transient conditions using this catalytic microreactor with steady-state kinetic rate expressions obtained using a conventional plug-flow microreactor employing the same Pd-GaOx\/SiO2 catalyst. Excellent agreement was found.  The reaction was also studied using a more active commercial methanol synthesis catalyst to assess the impact of heat and mass transfer resistances. For the full range of process conditions that was tested, the microreactor operated well under the kinetic regime.","palabras_clave":"Microcatalytic reactor|Transient experiments|Carberry-type|Kinetic regime"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17735,"idioma_id":5,"titulo":"CONSIDERACIONES ECOLÓGICAS SOBRE UNA POBLACIÓN DE LYCIUM ATHIUM BERNARDELLO (SOLANACEAE): PRIMER REGISTRO PARA SANTIAGO DEL ESTERO, ARGENTINA","resumen":"Lycium athium (Solanaceae) ha sido descripta como una especie endémica de la provincia de Formosa con muy pocos ejemplares citados a la fecha. Se cita por primera vez una población nativa para la provincia argentina de Santiago del Estero, lo que amplía su área de distribución y sugiere que podría extenderse a Paraguay. Nuevas colectas son necesarias para conocer su estatus en la naturaleza. Asimismo, se realizan contribuciones sobre las características de la población y de su hábitat. La población fue encontrada en la región del interfluvio de los ríos Dulce-Salado, tanto en sitios de vegetación arbustiva como de bosque. Se realizó un estudio comparativo entre ambos sitios. Para la caracterización de la población se tuvieron en cuenta las siguientes variables: densidad de la población, altura media de los individuos, abundancia y cobertura absolutas y relativas a las leñosas arbustivas, y patrón de distribución espacial. Para caracterizar el hábitat se determinó salinidad y acidez\/alcalinidad del suelo y la diversidad de especies leñosas y suculentas de cada comunidad. L. athium se encontró en suelos con elevada salinidad tanto en sitios con arbustivas halófilas como en áreas abiertas dentro del bosque, aunque estuvo mejor representada en el arbustal. Presentó un patrón de distribución espacial agregado en ambiente de arbustal y aleatorio en bosque. En ambos casos se presentó como una especie dominante en los estratos arbustivos bajos. La composición y diversidad de especies en ambos sitios fue la esperada para el tipo de ambiente dentro de la región.","palabras_clave":"LYCIUM ATHIUM|DISTRIBUCIÓN|SANTIAGO DEL ESTERO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17736,"idioma_id":4,"titulo":"Landscape-driven environmental variability largely determines abiotic characteristics and phytoplankton patterns in peat bog pools (Tierra del Fuego, Argentina)","resumen":"Ombrotrophic peat bogs from Tierra del Fuego are characteristically raised, domeshaped,fed by precipitation and nutrient-poor. Their landscape pattern consists of a Sphagnum magellanicum matrix encompassing pools with different morphometric and trophic features. Within the framework of a 2-year limnological survey in five pools from Rancho Hambre peat bog, we analysed phytoplankton communities under the hypothesis that taxonomic composition would show a spatial pattern driven by ultimately landscape-controlled environmental features such as pH and trophic status, whilst temperature and weather-dependent features would account for seasonal changes in abundance and structure. Among the 305 taxa recorded, most were  Conjugatophyceae and Bacillariophyceae, and were strongly associated to  circumneutral pH and minerotrophic conditions, though limited superficial connectivity among pools accounted for dissimilar taxonomic compositions. Despite such differences, phytoplankton of pools with similar morphometry and trophic status showed similar dominant and richest taxonomic groups undergoing like changes over time. Seasonal temperature fluctuations were modulated by pool size and modified not only abiotic properties but also phytoplankton abundance, with different taxa showing strong summer peaks in different pools. An interpretative model is proposed which will be tested as a tool for predicting community strategy and temporal variation patterns as responses to different environmental templates.","palabras_clave":"PHYTOPLANKTON|PEAT BOG POOLS|ENVIRONMENTAL DIVERSITY|LANDSCAPE|INTERPRETATIVE MODEL|LIMNOLOGICAL CHARACTERIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17737,"idioma_id":4,"titulo":"Three-dimensional reconstruction of the Aluminé in situ fossil forest from the Upper Oligocene of Rancahué Formation, Neuquén, Argentina","resumen":"This research focuses on the three-dimensional reconstruction of in situ Aluminé forest based on a fossil wood assemblages recovered in the Rancahué Formation (late Oligocene), Neuquén, Argentina. Atherospermataceae, Lauraceae, Nothofagaceae, Eucryphiaceae, Cunoniaceae and Myrtaceae are described. The mapping of a forest floor section and their in situ tree diameters allow obtain palaeoecological quantitative data like: tree density, dominance, basal area, biomass, diametric classes, canopy height, and age classes. Palaeoclimatical data were determined from physiognomic anatomical features using multivariate anatomical analyses. These results are compared with other proxies including Carlquist´s index, Coexistence Approach (CA), Nearest Living Relatives (NLRs), and growth-rings analyses. The structural data of Aluminé forest inferred from these analyses are tree density of 463?701 tree\/ha, mean height of 15.22 m, dominance of the genus Nothofagoxylon of 89.66 m2\/ha, total basal area of 158.20 m2\/ha, biomass between 43 and 712 tn\/ha and mean age of 223 years old (31?700 years old). These results are comparable to those of mature low to middle altitude extant forest dominated by Nothofagus, and developed under humid temperate conditions. Based on the NLRs method, the Aluminé forest has a floristic composition similar to the Valdivian forest today. The persistence of Nothofagus as dominant element in the temperate rainforests correlates with regimes where large-scale disturbances, such as volcanism and earthquakes are prevalent. The fossil taxa are closely related to extant Laurelia, Persea, Eucryphia, Nothofagus, Weinmannia, Myrceugenia and Luma. The forest contained intermixed deciduous and evergreen elements, shade-intolerance and intermediate tolerance to shade taxa. Also the majority of these taxa require water availability soil. The integrated analysis of multiple sets of proxy data suggests that the late Oligocene forest grew under a temperate and humid climate, and the eco-anatomical features and sedimentary data provide information about the environmental stress conditions of forest development and the violent causes of their burial.","palabras_clave":"3-D RECONSTRUCTION|OLIGOCENE|FOSIL FOREST|GROWTH RINGS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17738,"idioma_id":5,"titulo":"El cultivo del maíz en el Valle del Conlara (San Luis). Capítulo 5.","resumen":"El Valle del Conlara es unadepresión ubicada en el extremo noreste de la provincia de San Luis, enmarcadaentre las Sierras de San Luis (al oeste) y las Sierras de Comechingones (aleste). Su altitud oscila entre 500 y 900 m snm y las precipitaciones promedianlos 660 mmanuales. Los suelos son de origen aluvial y loessico, con buen drenaje, detexturas de franco-arenosa a franco-limosa y contenido moderado de materiaorgánica. El desarrollo agrícola tienesus comienzos en los primeros años del siglo XX (1905 a 1920), con la llegadadel ferrocarril y el establecimiento de una importante cantidad de inmigrantes europeos (en su mayoría italianos). Estos se dedicaron a la agricultura,incorporando nuevas técnicas de cultivo y maquinaria agrícola moderna (arados,sembradoras, espigadoras, trilladoras, etc.). Este fenómeno se dio conparticular énfasis en las localidades de Naschel, Estación Renca (actualTilisarao) y Dolores (actual Concarán). En la actualidad, el maíz sigueconstituyendo un cultivo fundamental como parte de la rotación agrícola, por elalto valor energético de sus granos, el importante aporte de rastrojos, elmejoramiento de la fertilidad del suelo y su contribución a la diversificación productiva de la empresa agropecuaria. Los ensayos que acontinuación se presentan son el resultado de investigaciones conjuntasllevadas a cabo entre la Universidad Nacional de San Luis, a través de las cátedras de Cereales y Oleaginosas y Mejoramiento Genético Vegetal, el Instituto Nacional deTecnología Agropecuaria (INTA) a través de la  EEA Villa Mercedes y la empresa BongiovanniAgro SRL","palabras_clave":"MAÍZ|CONLARA|SAN LUIS|MANEJO CULTIVO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17739,"idioma_id":5,"titulo":"Enseñanza de la ingeniería mediante los ejemplos y enigmas de la epistemología de Kuhn","resumen":"En este trabajo se pretende comprobar, a la luz de los postulados teóricos del epistemólogo Thomas Kuhn, la efectividad de la formación de nuevos científicos mediante ejemplos y enigmas a través del análisis de las metodologías aplicadas en el proceso de enseñanza de las asignaturas ?Práctica y Laboratorio I, II y III? de la carrera de ?Ingeniería Eléctrica?.   Si bien Thomas Kuhn es conocido principalmente por su definición de los conceptos de paradigma, revolución científica y proceso revolucionario que lleva al establecimiento de nuevos paradigmas, también aborda los procesos de enseñanza al tratar el tema del entrenamiento de nuevos científicos. Kuhn postula que la resolución de ejemplos y enigmas permite lograr además del entrenamiento una comprensión más profunda de los conceptos de los distintos paradigmas de la ciencia en cuestión.   Se ha realizado no solamente un análisis del contenido, desarrollo y modalidad de enseñanza de cada asignatura, sino que también se relacionaron las consignas de definición de problemas inspirados en situaciones reales, y de integración y articulación de contenidos, propias de estas asignaturas con los requerimientos respecto a los criterios de intensidad de la formación práctica, la formación experimental en laboratorio y la resolución de problemas de ingeniería de la Resolución 1232\/01 Estándares de acreditación de las carreras de ingeniería (MINISTERIO DE EDUCACIÓN, 2001).  A pesar del corto tiempo, desde 2007, que lleva el dictado de estas asignaturas, se ha podido observar que el concepto de entrenamiento por resolución de problemas ejemplares planteado por Kuhn, además de cumplir con lo dispuesto por la Resolución 1232\/01 citada logra los objetivos predichos por este epistemólogo respecto a una mayor comprensión de los conceptos, fenómenos y técnicas que abarca la ingeniería eléctrica.","palabras_clave":"EDUCACIÓN|INGENIERÍA ELÉCTRICA|EPISTEMOLOGÍA|ENSEÑANZA POR EJEMPLOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17740,"idioma_id":5,"titulo":"APOSTADEROS DE PINNÍPEDOS EN PUNTA ENTRADA (SANTA CRUZ, PATAGONIA ARGENTINA). EXPLOTACIÓN HUMANA E HISTORIA NATURAL","resumen":"El análisis de dos conjuntos zooarqueológicos de Punta Entrada, en la desembocadura del río Santa Cruz (Patagonia Argentina), permite abordar el tema de la existencia y explotación de apostaderos de lobos marinos en la localidad. Las características de estos conjuntos incluyen el predominio de los restos de pinnípedos, la representación de dos especies (Otaria flavescens y Arctocephalus australis), la presencia de ambos sexos y de individuos de diversas edades, modificaciones antrópicas y una gran diversidad de partes esqueletarias representadas. Los restos de cachorros de 1-1,5 meses en uno de los depósitos permiten establecer que el apostadero era reproductivo. Los perfiles anatómicos indican el transporte de individuos enteros o casi enteros desde un lugar cercano, que pudo ubicarse sobre la costa atlántica inmediatamente al sur de la localidad, donde la playa y el acantilado son similares a los hábitats en que los pinnípedos emplazan actualmente sus asentamientos. Otro lugar posible es el sector este de Punta Entrada, cuya historia de formación permite suponer que presentaba las mismas características. Además, las fuentes históricas mencionan una isla en el estuario en la que habitualmente se avistaban lobos marinos. Si bien estos hábitats son los que utiliza O. flavescens, la presencia de restos de A. australis en Punta Entrada permite suponer que esta especie también los utilizaba, aunque actualmente prefiera otros. Durante los últimos 2.000 años, el aprovechamiento de estos apostaderos por las poblaciones humanas no habría sido ni continuo ni relacionado con una estación específica del año.","palabras_clave":"apostaderos de pinnípedos|cazadores recolectores costeros|zooarqueología|Otaria flavescens|Arctocephalus australis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17741,"idioma_id":4,"titulo":"Continuity or Liquidation in Situations of Ambiguity: Fuzzy Binomial Model to Valuate Leveraged Firms","resumen":"Abstract  This paper proposes a fuzzy binomial valuation model to estimate leveraged firm value while conditioning its continuity or liquidation in cash flow generation after taxes to attend debt payments. It includes two triangular fuzzy variables. Thus, we incorporate ambiguity in the firm valuation process characterized by uncertainty in projections of both growth and financial costs. Our proposed model is presented, developed, and exemplified through a case which results complement both the DCF (under the adjusted present value) and the traditional real option binomial method. This occurs because, in one hand, DCF method assumes decisions? irreversibility and operating firms? situation. On the other hand, traditional binomial model weakens previous restrictions but does not incorporate ambiguous variables in the analysis. Hence, fuzzy logic applied to option models allows us to complement probabilistic valuation approach working on a frame of possibilities.","palabras_clave":"FIRM VALUATION|FUZZY SETS|BINOMIAL MODEL|UNCERTAINTY |ADJUST PRESENT VALUE|DEBT EFFECTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17742,"idioma_id":5,"titulo":"Sedimentología e Icnología de deltas fluvio-dominados afectados por descargas hiperpícnicas de la Formación Lajas (Jurásico Medio), Cuenca Neuquina, Argentina","resumen":"Existen pocos ejemplos reconocidos de sistemas deltaicos fluvio-dominados afectados por descargas  hiperpícnicas. El desarrollo de modelos predictivos en estos sistemas resulta clave para entender la distribución que presentan  las facies sedimentarias y para determinar la ubicación de los principales cuerpos arenosos, los cuales constituyen  los potenciales reservorios para la acumulación de hidrocarburos. En las áreas de Portada Covunco y Sierra de la Vaca  Muerta, la Formación Lajas constituye un excelente ejemplo de una sucesión deltaica fluvio-dominada integrada por  depósitos de prodelta y frente deltaico, afectados por descargas hiperpícnicas y reelaborados por acción de oleaje (normal  y de tormenta). Los depósitos de prodelta muestran una marcada geometría tabular con alternancia entre fangolitas y  areniscas finas con abundante contenido de materia orgánica y desarrollo de una icnofacies de Cruziana empobrecida.  Los depósitos de frente deltaico, integrados por fangolitas, areniscas finas a gruesas y conglomerados finos, presentan  cuerpos de geometría tabular con desarrollo de las icnofacies de Skolithos y Glossifungites, esta última relacionada con  la avulsión de lóbulos deltaicos. La progradación normal del sistema deltaico muestra intervalos estratigráficos integrados  por cuerpos lenticulares y tabulares de espesor variable asignados a canales y lóbulos hiperpícnicos. Internamente  estos depósitos presentan un pasaje transicional y recurrente entre diferentes estructuras sedimentarias con marcadas  variaciones texturales, múltiples superficies de reactivación interna, y abundante contenido de materia orgánica. Los  sistemas de canales hiperpícnicos muestran dimensiones y estilos de relleno diferentes. Al pie de las zonas de mayor  gradiente, las descargas hiperpícnicas generaron canales mayores con relleno agradacional, mientras que en posiciones  de menor gradiente del sistema, se desarrollaron canales de alta sinuosidad. En las zonas donde el flujo hiperpícnico  perdió confinamiento se produjo la acumulación de sistemas de lóbulos hiperpícnicos. La presencia de niveles de conglomerados  afectados por acción de oleaje coronando los arreglos, marcan los planos de pausa en la sedimentación, en  los cuales se desarrollaron ventanas de colonización para el establecimiento de la fauna bentónica.","palabras_clave":"Formación Lajas|Jurásico  |Delta fluvio-dominado|Hiperpicnitas|Icnología"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17743,"idioma_id":4,"titulo":"Arrhenius activation energy for water diffusion during drying of tomato leathers: the concept of characteristic product temperature","resumen":"The drying kinetics of tomato leathers was studied between 40 and 80 C and the corresponding  thermal histories were recorded. As air and product temperatures were found to  be considerably different during the drying runs, the original concept of ?characteristic  product temperature? was proposed. It is defined as the temperature corresponding to the  time at which the instantaneous drying rate is equal to the mean drying rate. Then, the  Arrhenius activation energies (Ea) obtained by two methods were compared: (1) correlating  the diffusion coefficient (D) with the air temperature and (2) correlating D with the characteristic  product temperature. Drying curves comprised a ?wet zone?, where moisture  content fell almost linearly with time, and a subsequent ?dry zone?. In the first zone, the  Arrhenius relationship with the air temperature yielded an Ea of 18.6 kJ mol1 whereas,  when utilising the characteristic product temperature the activation energy was  47.3 kJ mol1, comparable to the enthalpy of water desorption. In the second zone, activation  energies were 21.7 and 26.6 kJ mol1, respectively. Molecular mobility theory suggests  a stronger temperature dependence of diffusion-limited phenomena in high moisture  content matrices and thus would forecast a higher Ea for the wet zone. Therefore, the  characteristic product temperature is more meaningful than the air temperature in the  Arrhenius relationship.","palabras_clave":"TOMATO LEATHER|ACTIVATION ENERGY|DRYING|MATHEMATICAL MODELLING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17744,"idioma_id":5,"titulo":"Sistemas Adhesivos en Odontología Restauradora","resumen":"Los sistemas adhesivos  actuales han  permitido mejorar los procedimientos clínicos tanto en la evolución de los componentes y su mecanismo de acción, como en la disminución del tiempo operatorio de aplicación de cada uno de ellos, brindando una eficacia clínica aceptable y predecible. Esta demanda de efectividad, ha dado lugar a una gran variedad de sistemas adhesivos, que en muchas ocasiones, no se emplean en la práctica profesional. El propósito de este trabajo es  realizar una revisión  de los sistemas adhesivos a fin de brindar la información necesaria y secuencia de aplicación, que permita  al odontólogo realizar una adecuada selección  y utilización del sistema, de acuerdo a la situación clínica.","palabras_clave":"ADHESIÓN|BIOMATERIALES|OPERATORIA DENTAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17745,"idioma_id":4,"titulo":"Gelatine based films added with bacteriocins and a flavonoid ester active against food-borne pathogens","resumen":"Active films, based on food grade gelatine added with bacteriocins and\/or the flavonoid ester prunin laurate as antimicrobial compounds, were prepared. The films were characterized by water vapor permeability, mechanical property measurements and scanning electron microscopy. Film antibacterial activity was determined by the agar diffusion and direct contact microplate techniques against Listeria monocytogenes 01\/155, Staphylococcus aureus ATCC29213 and Bacillus cereus 1. Physical properties of gelatine films were not significantly affected by active compound incorporation. Antibacterial effect on each strain was dependent on the active compound incorporated into the film, but in all cases a synergistic inhibitory action was observed when both antimicrobial compounds were added. Thus, the results of this study suggest that gelatine based active films here presented could provide an alternative strategy for food biopreservation.","palabras_clave":"ACTIVE FILMS|GELATIN|ENTEROCINS|FLAVONOID ESTERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17746,"idioma_id":4,"titulo":"Synthesis of silver nanoparticles in surfactant-free light-cured methacrylate resins","resumen":"  tThe present study describes a simple method for preparing stable, highly dispersed spherical silvernanoparticles (Ag NPs) in surfactant-free methacrylate resins. Colloidal dispersions of silver in methacry-late resins were obtained by in situ reduction of silver nitrate. The reducing agents were hydroquinone(HQ), hydroquinone methyl ether (MEHQ) and 2,6-di-tert-butyl-para-cresol (BHT), which are added tothe resins to prevent premature polymerization. The obtained finely dispersed Ag NPs, that were 5?10 nmin diameter, were maintained in a stable colloidal state for more than nine months at ambient temper-ature. UV?vis and TEM analysis revealed that the particle size did not change with the reaction time.Moreover, UV?vis spectra and TEM micrographs of samples stored for 9 months, showed no drasticchange in average particle size. From these studies, it is concluded that the methacrylate resins used asreactive solvent act as efficient particle stabilizers preventing particle coalescence and thereby enablinglong term stability. The dispersions Ag NPs\/methacrylate resins were photoactivated with 0.5 wt% of2,2-dimethoxy-2-phenylacetophenone and were photo polymerized with a UV light source of irradiancecentred at 365 nm. The effective utilization of the surfaces of the formed metal nanoparticles is an advan-tage associated with nanoparticles formed via a surfactant-free synthesis method. The proposed processoffers the possibility to use these synthesized materials for the production of colour filters for opticaldevices and biomaterials with improved antimicrobial properties.The present study describes a simple method for preparing stable, highly dispersed spherical silvernanoparticles (Ag NPs) in surfactant-free methacrylate resins. Colloidal dispersions of silver in methacry-late resins were obtained by in situ reduction of silver nitrate. The reducing agents were hydroquinone(HQ), hydroquinone methyl ether (MEHQ) and 2,6-di-tert-butyl-para-cresol (BHT), which are added tothe resins to prevent premature polymerization. The obtained finely dispersed Ag NPs, that were 5?10 nmin diameter, were maintained in a stable colloidal state for more than nine months at ambient temper-ature. UV?vis and TEM analysis revealed that the particle size did not change with the reaction time.Moreover, UV?vis spectra and TEM micrographs of samples stored for 9 months, showed no drasticchange in average particle size. From these studies, it is concluded that the methacrylate resins used asreactive solvent act as efficient particle stabilizers preventing particle coalescence and thereby enablinglong term stability. The dispersions Ag NPs\/methacrylate resins were photoactivated with 0.5 wt% of2,2-dimethoxy-2-phenylacetophenone and were photo polymerized with a UV light source of irradiancecentred at 365 nm. The effective utilization of the surfaces of the formed metal nanoparticles is an advan-tage associated with nanoparticles formed via a surfactant-free synthesis method. The proposed processoffers the possibility to use these synthesized materials for the production of colour filters for opticaldevices and biomaterials with improved antimicrobial properties.","palabras_clave":"SILVER NANOPARTICLES|SURFACTANT- FREE|METHACRYLATE|PHOTOPOLYMERIZATION|NANOCOMPOSITES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17747,"idioma_id":4,"titulo":"LEAST SQUARE BASED METHOD FOR THE ESTIMATION OF THE OPTICAL END LOSS OF LINEAR FRESNEL CONCENTRATORS","resumen":"Small-scale solar concentrators based on Linear Fresnel Collectors (LFC) are a promising technology for domestic and industry applications. In such small systems, optical end losses and their influence on the energy performance are crucial issues. Although ray tracing is the most used method to estimate end losses, a less detailed and less time-consuming procedure is the analytical method, based on the equations that describe the sun and mirror positions. This method was used in this paper to study the behavior of the optical end losses with latitude and LFC geometry. A simple least square fitting expression was proposed to estimate the average annual nonilluminated length and the end loss factor for any latitude ? between 0 and ±40 ? and for any LFC azimuth. In particular, instantaneous, daily and annual periods at different latitudes for a North?South tracking LFC were analyzed. Finally, the instantaneous non-illuminated length on a short LFC system in Salta city, Argentina (24.7S, 65.4W) was&nbsp; experimentally determined through digital imaging analysis. A good agreement between the&nbsp; theoretical and the experimental values was found with average RMSE values of 6%.  2014 Elsevier Ltd. All rights reserved.","palabras_clave":"ANNUAL END LOSS ESTIMATION|SMALL-SCALE LINEAR FRESNEL CONCENTRATOR|NON-ILLUMINATED LENGTH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17748,"idioma_id":5,"titulo":"Potencial riesgo de polución biológica asociado a la introducción de Pinus radiata en tierras de pastizales","resumen":"La forestación es una  práctica recomendada para mitigar el cambio climático global. Sin embargo, su  implementación puede generar impactos no deseados, especialmente si se realiza  con especies exóticas. Plantaciones de Pinus  radiata D Don en  suelos del área de Ventania (Bs. As., Argentina) exhibieron aumentos notorios  del fósforo extractable (Pe), lo que podría afectar la dinámica de este  elemento, así como el grado de saturación con fósforo (GSPBray). Los objetivos del presente trabajo fueron: i) Cuantificar el GSPBray  en Molisoles implantados con P. radiata  contrastando los resultados con los provenientes de áreas adyacentes con  pastizales naturales (línea de base); ii) Evaluar el potencial riesgo ambiental  inducido por la forestación a partir de la identificación de un punto de cambio  (PC) en el GSPBray indicativo de un incremento de la lixiviación de  fosfatos. ","palabras_clave":"Polución biológica. |Fósforo soluble|P. radiata"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17749,"idioma_id":5,"titulo":"'Simulación del proceso fermentativo para la obtención de bioetanol a partir de residuos de arroz'","resumen":"En este trabajo se desarrolla un modelo de simulación del proceso fermentación\/separación de bioetanol a partirde cascarilla de arroz pretratada e hidrolizada, aplicando el simulador Aspen HYSYS&#61650;. Estudios de sensibilidadrealizados sobre el modelo desarrollado permitieron obtener niveles para las variables seleccionadas de 1:2,89relación biomasa:agua; 50 t\/h caudal de biomasa y 30°C temperatura de entrada al separador, que conducen amaximizar el rendimiento de bioetanol. A partir de estas variables se obtiene una producción de bioetanol de 8,81t\/h con una pureza del 65,51% p\/p equivalentes a un caudal de biomasa tratada hidrolizada de 50 t\/h. Estetrabajo representa un avance del desarrollo del modelado del proceso completo de obtención de bioetanol desegunda generación a partir de residuos de la industria arrocera.","palabras_clave":"Biocombustibles|Modelado|Residuos Lignocelulósicos|Fermentación alcohólica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17750,"idioma_id":4,"titulo":"White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter spp. and other bacteria of clinical importance","resumen":"Minocycline (MIN) and tigecycline (TIG) are antibiotics currently used for treatment of multidrug-resistant nosocomial pathogens. In this work, we show that blue light, as well as white light, modulates susceptibility to these antibiotics in a temperature-dependent manner. The modulation of susceptibility by light depends on the content of iron; an increase in iron results in a reduction in antibiotic susceptibility both under light and in the dark, though the effect is more pronounced in the latter condition. We further provide insights into the mechanism by showing that reduction in susceptibility to MIN and TIG induced by light is likely triggered by the generation of (1)O2, which, by a yet unknown mechanism, would ultimately lead to the activation of resistance genes such as those coding for the efflux pump AdeABC. The clinical relevance of these results may lie in surface-exposed wound infections, given the exposure to light in addition to the relatively low temperatures recorded in this type of lesion. We further show that the modulation of antibiotic susceptibility occurs not only in Acinetobacter baumannii but also in other micro-organisms of clinical relevance such as Escherichia coli and Staphylococcus aureus. Overall, our findings allow us to suggest that MIN and TIG antibiotic treatments may be improved by the inclusion of an iron chelator, in addition to keeping the wounds in the dark, a condition that would increase the effectiveness in the control of infections involving these micro-organisms.","palabras_clave":"ANTIBIOTICS|NOSOCOMIAL PATHOGENS|ACINETOBACTER|LIGHT MODULATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17751,"idioma_id":4,"titulo":". Genetic characterization of Escherichia coli isolated from cattle carcasses and feces in Mexico State","resumen":"Meat of bovine origin is one of the major vehicles in the transmission of verotoxigenic Escherichia coli (VTEC) to humanconsumers. This pathogen can produce serious human illness, including bloody diarrhea and hemolytic uremic syndrome. Theaim of the current study was to characterize E. coli isolates (mainly VTEC strains) belonging to several serotypes in samples fromcattle carcasses and feces of three municipal slaughter plants from Mexico State. The genetic diversity and molecular relatednessamong the isolates was evaluated with multiple-locus variable-number tandem repeat analysis (MLVA). To our knowledge, andwith the exception of E. coli O157:H7, this is the first time that serotypes analyzed here have been subtyped by MLVA inMexico. MLVA typing grouped the 37 strains from this study into 30 distinct genotypes, 26 of which were unique. Thesefindings indicate that cattle carcasses and feces from slaughter plants in Mexico are a source of VTEC that are genetically diversein terms of serotypes and virulence profiles. The presence of these pathogens in carcasses indicates the high probability of thespread of VTEC strains during slaughter and processing.","palabras_clave":"Escherichia coli|genetic characterization|mlva|cattle"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17752,"idioma_id":4,"titulo":"Modulation of Plasma Membrane Ca2+-ATPase by Neutral Phospholipids EFFECT OF THE MICELLE-VESICLE TRANSITION AND THE BILAYER THICKNESS","resumen":"The effects of lipids on membrane proteins are likely to be complex and   unique for each membrane protein. Here we studied                       different detergent\/phosphatidylcholine   reconstitution media and tested their effects on Plasma Membrane   Ca2+-pump (PMCA).                       We found that Ca2+-ATPase activity has a biphasic   behaviour respect to the detergent\/phosphatidylcholine ratio, whose   maximal                       value largely depends on the length and the   unsaturation degree of the hydrocarbon chain. Using Static Light   Scattering and                       Fluorescence Correlation Spectroscopy, we monitored   the changes in hydrodynamic radius of detergent\/phosphatidylcholine   particles                       during the micelle-vesicle transition. We found   that, when PMCA is reconstituted in mixed micelles, neutral   phospholipids                       increase the enzyme turnover. The biophysical   changes associated to the transition from mixed micelles to bicelles,   increase                       the time of residence of the phosphorylated   intermediate (EP) decreasing the enzyme turnover.                        Molecular Dynamics simulations analysis of the   interactions between PMCA and the phospholipid bilayer in which it is   embedded                       show that in the   1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayer, charged   residues of the protein are trapped in the                       hydrophobic core. Conversely, in the   1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) bilayer, the overall   hydrophobic-hydrophilic                       requirements of the protein surface are fulfilled   the best, reducing the thermodynamic cost of exposing charged residues   to                       the hydrophobic core. The apparent mismatch   produced by a DOPC thicker bilayer, could be a structural foundation to   explain                       its functional implication on PMCA.","palabras_clave":"CALCIUM ATPASE|ENZYME TURNOVER|LIPID BILAYER|MOLECULAR DYNAMICS|PROTEIN STRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17753,"idioma_id":4,"titulo":"Time-Course Study of Different Innate Immune Mediators Produced by Ultraviolet-Irradiated Skin. Comparative Effects of Short and Daily versus a Single Harmful UV Exposure","resumen":"The modulatory effects of solar ultraviolet radiation (UVR) on the immune system have been widely studied. As the skin is the main target of UVR, our purpose was to compare the impact of two contrasting ways to be exposed to sunlight on the skin innate immunity. Hairless mice were UV irradiated with a single high UV dose (shUVd) simulating a harmful exposure, or with repetitive low UV doses (rlUVd) simulating short occasional daily exposures. Skin samples were taken at different times post-UV irradiation to evaluate skin histology, inflammatory cell recruitment, epidermal T cell population and the mitochondrial function of epidermal cells. The transcriptional profiles of pro-inflammatory cytokines, chemokines, antimicrobial peptides and TLRs were evaluated by RT-PCR and ELISA in tissue homogenates. Finally, a lymphangiography was performed to assess modification in the lymphatic vessel system. A shUVd produces a deep inflammatory state characterized by the production of pro-inflammatory cytokines and chemokines that, in turn, induces the recruitment of neutrophils and macrophages into the irradiated area. On the other hand, rlUVd drive the skin to a photo-induced alert state in which there is no sign of inflammation, but the epithelium undergoes changes in thickness, the lymphatic circulation increases, and the transcription of antimicrobial peptides is induced.","palabras_clave":"INFLAMMATION|SKIN|ULTRAVIOLET RADIATION|PHOTOADAPTATION|CHEMOTAXIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17754,"idioma_id":4,"titulo":"Lipoteichoic acid challenge induces higher inflammatory responses than lipopolysaccharide in UV irradiated keratinocytes","resumen":"Keratinocytes  are the main cell population of the epidermis and play a crucial role in the  maintenance of skin homeostasis. Keratinocytes are in constant dialog with skin  commensal bacteria (mostly gram-positive) to prevent pathogen invasion. Solar  ultraviolet radiation impacts on skin and produces changes in the integrity of  the epithelia, allowing commensal bacteria to reach the dermis and trigger an  inflammatory response. We aimed to compare the antimicrobial response of UV  irradiated keratinocytes exposed to lipoteichoic acid and lipopolysaccharide by  the production of proinflammatory cytokines, IL-6 and TNF-&#945;, and the role of  Vitamin D pathway in this model. Surprisingly, keratinocytes response after UV  exposure was more intense to lipoteichoic than to lipopolysaccharide,  indicating that the disrupted epithelium reacts to commensal bacteria to avoid  potential infections. ","palabras_clave":"Inflammation|External barrier|microflora"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17755,"idioma_id":4,"titulo":"Fasciola hepatica excretory-secretory products induce CD4+T cell anergy via selective up-regulation of PD-L2 expression on macrophages in a Dectin-1 dependent way","resumen":"Fasciola hepatica excretory-secretory products (FhESP) induce immunomodulatory effects   on macrophages. Previously, we demonstrated that these effects are dependent on Dectin-1. Therefore,   the aim of this study was to determine how this affects the CD4+T-cells immune response.We observed   that FhESP induce an increased expression of PD-L2 in macrophages via Dectin-1. Furthermore, in   co-cultures with CD4+T-cell we observed a suppressive effect on proliferative response, downmodulation of IFN-&#947; and up-modulation of IL-10 via Dectin-1 on macrophages. These results suggest   that FhESP induce T-cell anergy via selective up-regulation of PD-L2 expression on macrophages in a   Dectin-1 dependent way.","palabras_clave":"FASCIOLA HEPATICA|DECTIN-1|MACROPHAGES|CD4+T CELLS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17756,"idioma_id":5,"titulo":". Interacción genótipo-ambiente y estabilidad en la producción de forraje de triticales y tricepiros","resumen":"Triticales y tricepiros son alternativas forrajeras anuales que diversifican la oferta de cereales invernales. El triticale (x Triticosecale Wittmack) es producto de la cruza de Triticum L. x Secale L. en sentido amplio. Tricepiro es el nombre vulgar de las combinaciones trigenéricas obtenidas por cruzamientos entre triticales y trigopiros (Triticum L. x Thinopyrum Á. Löve). El objetivo de este trabajo fue analizar la interacción genotipo-ambiente y la estabilidad del rendimiento en forraje de líneas experimentales. Se emplearon 23 genotipos evaluados durante cinco años en Río Cuarto, Córdoba y Santa Rosa, La Pampa. Mediante ANAVA se determinaron los efectos principales genotipo, ambiente y la interacción genotipo-ambiente, todos ellos estadísticamente significativos. La estabilidad se determinó mediante análisis de la regresión, índice Pi y modelos AMMI2 y SREG. Una línea de triticale resultó de alto rendimiento y escasa interacción genotipo-ambiente con todos los métodos, mientras que otra, de alto rendimiento y muy estable según la regresión y el índice Pi, resultó de muy buen rinde pero poco estable según AMMI y de alto rendimiento sólo en un ambiente según SREG. Respecto a las líneas de tricepiro, cuatro de rendimiento superior al promedio resultaron estables según método de la regresión pero el índice Pi calificó como estable sólo una y en el AMMI todas resultaron inestables. En el análisis SREG una resultó estable y rendidora, otra tuvo mediana interacción genotipo-ambiente y rendimiento superior pero muy cercano a la media y las restantes resultaron inestables. Los análisis permitieron identificar tres líneas para su registro como cultivares.","palabras_clave":"TRITÍCEAS HÍBRIDAS|FORRAJE|INTERACCIÓN GENOTIPO-AMBIENTE|ESTABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17757,"idioma_id":5,"titulo":"Historia, política y ficción: algunos ejemplos de la literatura latinoamericana contemporánea","resumen":"Frente a la afirmación de Rosalba Campra de que las lecturas son tan epocales como la escritura, donde cada circunstancia histórica hace que determinados textos, contemporáneos o no, se lean como esclarecedores del momento en que se los lee, presentamos este trabajo desde un interrogante central: ¿cuáles son las relaciones entre historia, política y ficción que se lía en los textos? Hoy sabemos que, más allá de toda ilusión o automatismo crítico al que refiere con razón Campra, existe una textualidad o, mejor, unos corpora que nos hablan con insistencia de los acontecimientos vinculados a las dictaduras que asolaron hasta las últimas décadas del siglo XX lo que se conoce como el Cono Sur de América latina. Tales producciones no sólo se han materializado en novelas y cuentos, sino también en poesía, cine, pintura, teatro, etc. En este sentido, las relaciones entre los creadores de ficciones y sus épocas encuentran una justificación empírica que, en distintos casos, nos permite vislumbrar una percepción o interpretación de esos discursos que circulan en un tiempo y en un lugar determinados. El artículo discute el valor de la categoría 'novela histórica' y retoma la propuesta de Linda Hutcheon, 'metaficción historiográfica', que permite dar cuenta de la relación interdiscursiva historia \/ ficción. Se presentan tres novelas chilenas (Lemebel, Bolaño y Tatiana Lobo Wiehoff) que re-visitan los acontecimientos de la última dictadura chilena.","palabras_clave":"Lectura y Escritura|Textos de ficción|Dictaduras|Discursos de época"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17758,"idioma_id":5,"titulo":"?EVALUAR LA SUSTENTABILIDAD DE LOS AGROECOSISTEMAS: UN DESAFÍO EN LA FORMACIÓN DEL ESTUDIANTE DE INGENIERÍA AGRONÓMICA?.","resumen":"El modelo de agricultura vigente es inviable a largo plazo, siendo necesario desarrollar agroecosistemas sustentables. Se requiere un nuevo profesional de las Ciencias Agrarias, con un mayor conocimiento de los mismos desde una óptica holística y sistémica con un sólido espíritu crítico y valores éticos. Este desafío requiere un cambio profundo de los contenidos y metodologías de enseñanza en las instituciones de educación agrícola (Sarandon, 2008). Los docentes universitarios deben generar instancias de formación que coloquen al estudiante en un papel protagónico y dinámico? (Coronado, 2009; Rué, 2009). Siguiendo estas líneas de pensamiento, en el marco institucional del Taller de Integración I: La investigación en las Ciencias Naturales y Sociales de la carrera Ingeniería Agronómica, un grupo de docentes de la Facultad de Ciencias Agrarias de la UNR comenzó a incorporar la evaluación de la sustentabilidad de los agroecosistemas del sur de Santa Fe como tema de investigación.El presente trabajo tiene como objetivo general explorar las ventajas comparativas que tiene para la formación profesional incorporar la temática de la sustentabilidad de los agroecosistemas como tema de investigación. Asimismo, se plantearon como objetivos específicos: identificar las competencias adquiridas por los estudiantes y conocer la opinión sobre la experiencia para mejorar las estrategias de enseñanza.","palabras_clave":"AGROECOSISTEMAS |SUSTENTABILIDAD |FORMACIÓN |INGENIERO AGRÓNOMO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17759,"idioma_id":4,"titulo":"Variation in body size and degree of melanism within a lizards clade: is it driven by latitudinal and climatic gradients?","resumen":"Body size (BS) varies in response to several selective pressures. In ectotherms,thermal inertia may affect thermoregulation, since larger BSs increase heat conservationas Bergmann originally stipulated for endotherms. However,Bergmann?s rule is controversial in ectotherms. The heat balance hypothesis statesthat ectotherms? thermoregulatory capability is relevant for trends in BS. In coldclimates, larger BSs would be advantageous for small thermoregulatingectotherms, by increasing heat conservation. However, BS implies a delayingeffect on heating too; therefore, ectotherms may need another trait to compensatethe later effect. Thermal melanism hypothesis posits that melanism increases heatgain, and may be adaptive for animals inhabiting cold climates. We propose thatthe higher solar radiation absorption from increased melanism may be such acompensatory trait. We expect BS and melanism to increase with latitude inresponse to seasonal temperatures and solar radiation. To test this, we studied themonophyletic Liolaemus goetschi group of lizard species across its 2200 km (32?48° S latitude) range. We used phylogenetically informed analyses to study geographicvariation of BS and melanism (dorsal, ventral and total) in relation totemperatures, thermal amplitude, cloudiness and net solar radiation. Our resultsshow that lizards? BS increases latitudinally in relation to thermal amplitude andtemperature. Only ventral melanism varied latitudinally, but all melanism variablesvaried in response to cloudiness and net radiation. The relationship betweenBS and melanism was significant and positive in all cases. We suggest thermalinertia may be a fair candidate mechanism explaining geographic variation in BS(heat balance hypothesis), while melanism may influence heat gain according tothe thermal melanism hypothesis. However, it remains unclear why latitudinalvariation is related to ventral instead of dorsal melanism, and further investigationis needed to clarify the relationship between BS and melanism in light of coldclimates.","palabras_clave":"thermal melanism hypothesis|heat balance hypothesis|bergmann´s rule|ectotherms"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17760,"idioma_id":4,"titulo":"Preparation and Characterization of a Staphylococcus aureus Capsular Polysaccharide-Protein Conjugate Prepared by a Low Cost Technique: a Proof-of-Concept Study","resumen":"Staphylococcus aureus is a worldwide   distributed pathogen that produces several diseases in many species and   is the major cause of mastitis in dairy cows. S. aureus   capsular polysaccharide 5 (CP5) has been widely proposed as a vaccine   candidate since it is expressed in a high proportion of isolates from   intramammary infections and is able to induce opsonophagocytic   antibodies. However, to reach immunological properties, polysaccharides   need to be coupled to carrier proteins. The aim of this study was to   evaluate a conjugation method employing p-benzoquinone (PBQ), which was not previously reported for the development of vaccine components. Purified S. aureus   CP5 was coupled to human serum albumin (HSA) with high efficiency,   reaching a rate PS\/protein of 0.5. Mice groups were immunized at days 0,   14, 28, and 42, with the conjugate (CP5-HSAPBQ),   free CP5, or PBS, formulated with incomplete Freund adjuvant, and after   3&nbsp;months, they were challenged with free CP5 to evaluate the memory   response. IgG and IgM isotypes were measured on serum samples all along the experiment, and IgG subclasses were determined to analyze the humoral profile. In contrast to the response obtained with free CP5, CP5-HSAPBQ induced IgG   titers of 1\/238,900 after three doses and a memory response was   observed after the challenge. Results indicate that immunization with   CP5-HSAPBQ effectively induce a   T-dependent immune response against CP5. Moreover, besides IgG2a was the   main subtype obtained, the joint production of specific IgG1, IgG2b,   and IgG3 types indicated a balanced humoral response. As p-benzoquinone   conjugation of CPs to proteins is far less expensive and   straightforward than other methods commonly used in vaccine   preparations, the robust humoral response obtained using this method   points out that this can be an interesting alternative to prepare S. aureus CP5 conjugate vaccines.","palabras_clave":"Staphylococcus aureus|capsular polysaccharide 5|mastitis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17761,"idioma_id":4,"titulo":"Prediction of structural and metal-to-semiconductor phase transitions in nanoscale MoS 2 , WS 2 , and other transition metal dichalcogenide zigzag ribbons","resumen":"While MoS2 and WS2 nanostructures gain an increasing importance in a number of recent technological applications, the control of their structure as a function of their size and their environment appears of prominent importance. In the present study which relies on first-principles simulations, we predict the dimerized 1T structural phase to be the actual ground state of MoS2 , WS2 , and MoSe2 zigzag nanoribbons of small width and monolayer thickness. We assign this result to the competition between edge energy?which favors the nonpolar 1T edges over the polar 1H edges?and the energy of atoms in the center of the ribbons?which favors the 1H ground state of the infinite monolayers. A metal-to-semiconductor transition accompanies the structural transition. At variance, ZrS2 zigzag ribbons are predicted to display the 1T structure whatever their width. Incompounds of major technological importance, such structural and electronic flexibility associated with polarity effects opens the possibility for controlling the ribbon type during synthesis.","palabras_clave":"Transition Metal dichalcogenides|Nanoribbons|Polarity|Phase stability"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17762,"idioma_id":4,"titulo":"A first principles study of He,Xe,Kr and O incorporation in thorium carbide","resumen":"Thorium-based materials are currently being investigated in relation with their potential utilization in Generation-IV reactors as nuclear fuels. Understanding the incorporation of fission products and oxygen is very important to predict the behavior of nuclear fuels. A first approach to this goal is the study of the incorporation energies and stability of these elements in the material. By means of first-principles calculations within the framework of density functional theory, we calculate the incorporation energies of He, Xe, Kr and O atoms in Th and C vacancy sites, in tetrahedral interstitials and in Schottky defects along theh111i and h100i directions. We also analyze atomic displacements, volume modifications and Bader charges. This kind of results for ThC, to the best authors? knowledge, have not been obtained previously, neither experimentally, nor theoretically. This should deal as a starting point towards the study of the complex behavior of fission products in irradiated ThC.","palabras_clave":"Generation IV reactors|Thorium Carbide|DFT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17763,"idioma_id":5,"titulo":"CONEXIÓN CRETÁCICA ENTRE LAS CUENCAS DEL GOLFO SAN JORGE Y CAÑADÓN ASFALTO (PATAGONIA): PALEOGEOGRAFÍA, IMPLICANCIAS TECTONOESTRATIGRÁFICAS Y SU POTENCIAL EN LA EXPLORACIÓN DE HIDROCARBUROS","resumen":"      El Grupo Chubut (Cretácico) en la cuenca del Golfo San Jorge se  inicia con el sistema depositacional fluvial-lacustre de las formaciones  Matasiete-Pozo D-129 (Barremiano?-Aptiano). Esta contribución evalúa la  correlación entre la   Formación Matasiete y sus equivalentes laterales de la cuenca  de Cañadón Asfalto. Se caracterizó a la Formación Los Adobes  en Cañadón Puelman y cerro Punta Toro Hosco, sector noroccidental de la cuenca;  los canales presentan espesor máximo promedio (T) de 7 m, relación ancho  real\/potencia máxima (W\/t) promedio de 10 y dirección de paleoflujo hacia 168º.  La Formación   Cerro Fortín se analizó próxima al cerro Ferrarotti; los  canales presentan una geometría promedio definida por T: 4,6 m, W\/t: 16, y dirección  de paleoflujo hacia 162º. Aguas abajo de ambas localidades aflora la Formación Matasiete,  con canales fluviales con valores promedio de T: 7,3 m, W\/t: 14 y dirección de  paleotransporte al S-SE. La similitud litológica, consistencia  entre las direcciones de paleoflujo y la geometría comparable de sus  paleocanales sustentan la correlación física entre las unidades  litoestratigráficas mencionadas. Utilizando análogos modernos se definió una  zona de cabeceras mínima para el lago de la Formación Pozo D-129  de ~160.000 km2, con cabeceras fluviales individuales de ~4.000 km2.  Los resultados obtenidos definen un escenario paleogeográfico con redes de  drenaje que fluyen desde el norte-noroeste utilizando corredores sedimentarios  de origen tectónico. La caracterización de un sistema depositacional  continental conectando áreas de la cuenca de Cañadón Asfalto y del Golfo San  Jorge define potenciales guías de prospección de hidrocarburos en áreas de  frontera.    ","palabras_clave":"CUENCA GOLOFO SAN JORGE|CUENCA CAÑADÓN ASFALTO|GRUPO CHUBUT|APTIANO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17764,"idioma_id":5,"titulo":"ARQUITECURA ESTRATIGRÁFICA DEL PALEOCENO EN EL FLANCO NORTE DE LA CUENCA DEL GOLFO SAN JORGE, PATAGONIA CENTRAL","resumen":"La depositación de la Formación Salamanca y del Grupo Río Chico (Paleoceno) en la Cuenca del Golfo San Jorge excedió el ámbito de la cuenca continental del Grupo Chubut (Cretácico). Estas unidades muestran cambios estratigráficos significativos en dirección norte-sur para el flanco norte de la cuenca. Por un lado, la acumulación de depósitos bioclásticos basales en la Formación Salamanca (Miembro Bustamante) sólo tuvo lugar en el borde norte de la cuenca, donde la sedimentación marina ocurrió sobre rocas volcánicas jurásicas del Complejo Marifil. Hacia el sur, la transgresión inicial está representada por los depósitos epiclásticos del Miembro Hansen (?Glauconítico?), apoyados sobre el Grupo Chubut (Cretácico). Así, los depósitos bioclásticos del Miembro Bustamante se interpretan como una evidencia del desarrollo de colonias de invertebrados marinos sustrato-controladas, ya que las rocas volcánicas constituyeron un sustrato más propicio para su colonización por organismos incrustantes en ambientes intermareales y submareales. Por el otro, las variaciones norte-sur en la macro-arquitectura aluvial del Grupo Río Chico quedan reflejadas por variaciones en los estilos fluviales, en la geometría externa de los canales, por la preservación variable de la planicie de inundación, y por cambios sistemáticos en el espesor total de la unidad, sugiriendo cambios temporo-espaciales en el espacio de acomodación durante su depositación.Los cambios en el registro estratigráfico paleoceno están espacialmente sobreimpuestos con el límite norte de la cuenca continental del Grupo Chubut. La reactivación extensional paleocena de este borde de cuenca heredado, controló la macro-arquitectura estratigráfica paleocena en el flanco norte de la cuenca.","palabras_clave":"FORMACIÓN SALAMANCA|GRUPO RIO CHICO|BORDE DE CUENCA CRETÁCICO|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17765,"idioma_id":4,"titulo":"ALLUVIAL ARCHITECTURE OF REWORKED PYROCLASTIC DEPOSITS IN PERI-VOLCANIC BASINS: CASTILLO FORMATION (ALBIAN) OF THE GOLFO SAN JORGE BASIN, ARGENTINA","resumen":"La distribución espacial de litofacies y asociaciones de litofacies es primordial para entenderlas variaciones en los estilos fluviales y dimensiones de los canales, los controles externos yel grado de predictibilidad de la arquitectura aluvial de depósitos piroclásticos retrabajadosen cuencas peri-volcánicas. Estos aspectos se analizan en este estudio sobre la FormaciónCastillo (Albiano) de la cuenca del Golfo San Jorge en la Faja Plegada de San Bernardo, ungrupo de sierras con orientación N-S, ubicadas 190 km al este de la Cordillera de losAndes. Se conformó un marco estratigráfico detallado basado en 19 seccionesestratigráficas y la caracterización de 284 canales fluviales, analizando siete localidadesdesde el margen norte de la cuenca, a la sección más completa en el extremo sur de la fajaplegada. La unidad se dividió en quince litofacies, agrupadas en seis asociaciones delitofacies: (i) planicies de inundación subaérea y subácuea, (ii) planicie proximal, (iii)canales fluviales de baja sinuosidad y entrelazados, (iv) depósitos de flujos de detritos, (v)flujos no encauzados, (vi) niveles de ceniza retrabajada. Las variaciones en la proporciónde asociaciones de litofacies y en las dimensiones de los depósitos clásticos estánrelacionadas a aporte variable de agua y partículas volcaniclásticas en redes de drenajelocales o regionales desarrolladas en areas de variable tasa de subsidencia. Pese al controldel volcanismo sobre la composición de los depósitos volcaniclásticos, los rasgoscaracterísticos del sistema fluvial preservado en esta cuenca peri-volcánica fueronmayormente establecidos por procesos intracuencales.","palabras_clave":"PERI-VOLCANIC BASINS|FLUVIAL ARCHITECTURE|GOLFO SAN JORGE BASIN|CRETACEOUS|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17766,"idioma_id":5,"titulo":"ANÁLISIS PETROGRÁFICO DE ARENISCAS DE LA FORMACIÓN CASTILLO (ALBIANO) EN LA FAJA PLEGADA DE SAN BERNARDO, CUENCA GOLFO SAN JORGE, ARGENTINA","resumen":"Con el objeto de analizar las variaciones espaciales en la petrografía sedimentaria de laFormación Castillo (Albiano) se caracterizó el relleno arenoso de canales fluviales en tresáreas de la faja plegada de San Bernardo, Chubut. Estas tres regiones geográficas ygeológicas presentan variaciones en el sistema fluvial, y por tanto en el ordenamiento desus facies, que también se ve reflejado en la petrografía de la unidad. Para el análisis de lasmodas detríticas se identificaron variedades de cuarzo, feldespato y líticos presentes en lasareniscas. El análisis petrográfico de las diferentes regiones, permitió identificar áreas conredes de drenaje pequeñas y de carácter local (región 2) en donde la composición de lafracción clástica permite inferir áreas de aporte locales, y redes de drenaje de mayorjerarquía y grado de integración (región 4) que reflejan un área de aporte regional. Estasdiferencias también se observan en diagramas ternarios de procedencia, los que muestranun cambio del área de procedencia dentro de un arco transicional, cercano al campo de unarco no disectado para muestras de redes de drenaje locales, a un arco disectado paramuestras de redes de drenaje de dimensiones regionales. El análisis de la fracción clástica ysus componentes reveló también que la porosidad secundaria observada en las areniscas esmayormente producto de alteración diagenética de los componentes neovolcánicos. Sinembargo, para que esta porosidad sea efectiva, las areniscas deben estar cementadas conceolitas de tipo heulandita-clinoptilolita o bien por arcillas de tipo rim.","palabras_clave":"PETROGRAFÍA|DIAGÉNESIS|FORMACIÓN CASTILLO|GRUPO CHUBUT|CUENCA DEL GOLFO SAN JORGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17767,"idioma_id":4,"titulo":"Asymmetric behavior in the excitation of plasmons by ions entering or leaving a material in an oblique trajectory","resumen":"Asymmetric behavior in the excitation of plasmons by ions entering or leaving a material in an oblique trajectoryJ L Gervasoni, S Segui, R O BarrachinaJournal of Physics: Conference Series 583 (2015) 012028, 4pag.","palabras_clave":"BEHAVIOR|PLASMONS|TRAJECTORY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17768,"idioma_id":4,"titulo":"Exact photoionization and radiative recombination cross section in a Coulomb potential","resumen":"In this work, we analytically evaluate the exact matrix element for a non-relativistic Continuum-Bound radiative transition in a Coulomb potential. We apply this result to the photoionization (and radiative recombination) process, and calculate the total cross sections giving an analytical expression for the transition from the ground state. To our best knowledge the exact solution to this problem has never been addressed even though the analytical calculation is quite simple, and the final result is not more complicated than any of its approximations. We compare our result with the well-known plane wave and Coulombian dipolar approximations, in a wide range of energies.","palabras_clave":"PHOTOIONIZATION|RECOMBINATION|COULOMB"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17769,"idioma_id":4,"titulo":"Zero energy resonances in atomic processes within a plasma","resumen":"We investigate different atomic processes that might occur in the interior of plasmas. In particular we apply the Final-State Interaction theory in order to study the behavior of the corresponding cross sections when the relative energy of a pair of charged particles in the initial or final states vanishes. Through this analysis we uncover the presence of zero - energy resonances for particular configurations of density and temperature. For fusion plasmas, these effects might have an important impact on the working conditions and performance of the reactor.","palabras_clave":"PLASMA|ATOM|RESONANCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17770,"idioma_id":4,"titulo":"Vortices in the Three-Body Electron-Positron-Proton Continuum System induced by the Positron-Impact Ionization of Hydrogen","resumen":"By means of a systematic theoretical study of the transition matrix element T for the e + H ionization collisions in a collinear geometry, we uncover the presence of three isolated zeros at intermediate impact energies. We demonstrate that these zeros actually represent vortices in the generalized velocity field associated to T. One of these vortices is shown to be related to a deep minimum observed more than two decades ago by Brauner and Briggs in 1991 at extremely large impact energies, where the corresponding fully differential cross section was too small to be experimentally accessible. Here we elucidate that it might still be present at much smaller impact energies, thus being amenable to experimental investigation. Furthermore, we discovered that this vortex is paired with a second one of opposite circulation, in accordance with one of the scenarios for their emergence. We study the location of these vortices and find that they seem to be located at, emerge from, or move towards specific points which could be related to particular collision mechanisms, as the direct ionization and capture to the continuum cusps, or the saddle-point and Thomas processes.","palabras_clave":"IONIZATION|VORTEX|POSITRON|ATOM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17771,"idioma_id":4,"titulo":"Effect of synthetic steroids on GABAa receptor binding in rat brain","resumen":"Neuroactive steroids, like allopregnanolone (A) and pregnanolone (P), bind to specifics sites on the GABAA receptor complex and modulate receptor function. They are capable to inhibit or stimulate the binding of GABAA receptor specific ligands, like t-butylbicyclophosphorothionate, flunitrazepam and muscimol. We have previously characterized a set of oxygen bridged synthetic steroids (SS) analogues to A or P using synaptosomes. Considering that the subunit composition of the GABAA receptor&nbsp; throughout the central nervous system affects the magnitude of the modulation of the GABAA receptor by NAS, we evaluated the action of two selected SS, in brain sections containing cerebral cortex and hippocampus using quantitative receptor autoradiography. Both SS affected the binding of the three ligands in a similar way to A and P, with some differences on certain cerebral cortex layers according to the ligand used. One of the SS, the 3beta-hydroxy-6,19- epoxypregn-4-ene-20-one (compound 5), behaved similarly to the natural neuroactive steroids. However, significant differences with compound 5 were observed on the hippocampus CA2 region, making it steroid suitable for a specific action. Those differences may be related to structural conformation of the SS and the subunits? composition present on the receptor complex.","palabras_clave":"NEUROSTEROIDS|GABAA RECEPTOR|CEREBRAL CORTEX|HIPPOCAMPUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17772,"idioma_id":4,"titulo":"Synthesis and characterization of a new polyaminocarboxylic macrocyclic ligand and its non-ion gadolinium complex. In vitro relaxivity studies at 0.2 T","resumen":"In this study a novel ligand with three carboxylic groups (H3L1) was synthesized. Its non-ion complex with GdL1 holding promise of magnetic resonance imaging (MRI) was synthesized, and the relaxivity of the complex determined. The relaxivity of GdL1 (R1 = 4.5 Mmol- 1·s- 1) was larger than that of Gd(DTPA)2 -(R1 = 3.9 Mmol- 1·s- 1). The results showed that the non-ion complex is a prospective MRI contrast agent.","palabras_clave":"MAGNETIC RESONANCE IMAGING|GADOLINIUM COMPLEX|RELAXIVITY|CONTRAST AGENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17773,"idioma_id":5,"titulo":"Flujos informacionales en repositorios cooperativos: consideraciones sobre algunas experiencias en instituciones académicas de América Latina","resumen":"Este trabajo, de  tipo descriptivo exploratorio, se propone efectuar un análisis de una serie de repositorios  cooperativos pertenecientes a instituciones académicas de América Latina. Hace  hincapié en la importancia de la cooperación como práctica de larga data en el  ámbito de las bibliotecas, muchas de las cuales se han convertido en líderes o  partícipes importantes tanto en la implementación como en el desarrollo de los  repositorios en sus respectivas instituciones. Se toman en consideración los  flujos informacionales que los atraviesan a fin de conocer cómo se delinean y  desarrollan en el marco de instituciones académicas de cierta envergadura y  complejidad, a través de un análisis de documentación. Se resaltan los modelos  de flujos de información que se detectan en dichos repositorios cooperativos y  cómo, desde su singularidad, favorecen la visibilidad y la difusión del  conocimiento académico y científico existente en formato digital. ","palabras_clave":"REPOSITORIOS COOPERATIVOS|FLUJOS DE INFORMACION|COOPERACION BIBLIOTECARIA|AMERICA LATINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17774,"idioma_id":4,"titulo":"?Galectin-1 triggers epithelial-mesenchymal transition in human hepatocellular carcinoma cells',","resumen":"Galectin-1 (Gal1), a &#946;-galactoside-binding protein abundantly expressed in tumor microenvironments, is associated with the development of metastasis in hepatocellular carcinomas (HCC). However, the precise roles of Gal1 in HCC cell invasiveness and dissemination are uncertain. Here, we investigated whether Gal1 mediate epithelial-mesenchymal transition (EMT) in HCC cells, a key process during cancer progression. We used the well-differentiated and low invasive HepG2 cells and performed ´gain-of-function´ and ´loss-function´ experiments by transfecting cells with Gal1 cDNA constructs or by siRNA strategies, respectively. Epithelial and mesenchymal markers expression, changes in apico-basal polarity, independent-anchorage growth, and activation of specific signaling pathways were studied using Western blot, fluorescence microscopy, soft-agar assays, and FOP\/TOP flash reporter system. Gal1 up-regulation in HepG2 cells induced down-regulation of the adherens junction protein E-cadherin and increased expression of the transcription factor Snail, one of the main inducers of EMT in HCC. Enhanced Gal1 expression facilitated the transition from epithelial cell morphology towards a fibroblastoid phenotype and favored up-regulation of the mesenchymal marker vimentin in HCC cells. Cells overexpressing Gal1 showed enhanced anchorage-independent growth and loss of apico-basal polarity. Remarkably, Gal1 promoted Akt activation, &#946;-catenin nuclear translocation, TCF4\/LEF1 transcriptional activity and increased cyclin D1 and c-Myc expression, suggesting activation of the Wnt pathway. Furthermore, Gal1 overexpression induced E-cadherin downregulation through a PI3K\/Akt-dependent mechanism. Our results provide the first evidence of a role of Gal1 as an inducer of EMT in HCC cells, with critical implications in HCC metastasis.","palabras_clave":"Galectin-1|Carcinoma hepático|Transición mesenquimal-epitelial"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17775,"idioma_id":5,"titulo":"Escarabajos copronecrófagos (Scarabaeidae: Scarabaeinae) de la Reserva Natural Educativa Colonia Benítez, Chaco, Argentina.","resumen":"Se describe la composición de escarabeinos de la Reserva Natural Educativa Colonia Benítez. Se realizaron seis muestreos en bosque de quebracho y selva en galería en período seco y lluvioso. Los escarabajos se recolectaron mediante trampas cebadas con materia fecal y calamar, y con trampas de luz. Se recolectaron 3369 ejemplares de 26 especies. Eurysternus aeneus, Canthon quinquemaculatus, C. chalybaeus, Deltochilum komareki y Canthidium (Canthidium) sp., representaron el 65% del total de individuos. Los estimadores no paramétricos de riqueza, sugieren un porcentaje alto de completitud del inventario. La estructura del ensamble varió significativamente entre períodos, diferentes tipos de cebo y en los meses de muestreo, no así entre ambientes. En secas, la abundancia y diversidad fueron mayores que en el período lluvioso. En marzo del 2011 se registró la mayor riqueza, diversidad y abundancia. Mediante trampas cebadas con materia fecal se obtuvo la mayor riqueza y con las de calamar la mayor abundancia. La temperatura máxima fue la variable que mejor explicó los cambios en la composición del ensamble. La riqueza observada demuestra que incluso pequeñas zonas boscosas son importantes áreas de conservación. Este es el primer estudio de la diversidad de Scarabaeinae en el Sitio Ramsar Humedales Chaco.","palabras_clave":"diversidad|Coleoptera|área protegida|ambientes nativos|noreste argentino"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17776,"idioma_id":4,"titulo":"Development and structural validation of a scale to assess regulation of anger and sadness in interpersonal situations","resumen":"The purpose of this research was to develop and validate a new instrument to assess the regulation of anger and sadness in interpersonal situations, covering a wide range of emotion regulation strategies. Two studies were carried out, both of them using purposively selected samples. In Study 1 we created a set of items based on previous studies of emotion regulation, applied a preliminary version of this scale to a pilot sample of undergraduate students (n = 400), and then selected, using exploratory factor analysis (EFA)  , the best 28 items to include in a brief version of the instrument, the Scale of Emotion Regulation in Interpersonal Situations (SERIS). In Study 2 we tested the resulting scale in a new sample of undergraduate students (n = 259) by means of confirmatory factor analysis. Study 2 validated the factor structure identified in the EFA. Results showed that the scale has adequate internal consistency and psychometric properties. The new scale also identifies the strategies that are most frequently used in the anger and sadness scenarios, showing differential patterns which are consistent with previous literature on emotion regulation. We discuss the limitations of the study and acknowledge that future studies addressing the scale?s convergent and discriminant validity are now required.","palabras_clave":"EMOTIONS|EMOTION REGULATION|INTERPERSONAL SITUATIONS|STRUCTURAL VALIDATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17777,"idioma_id":5,"titulo":"Factores extrínsecos e intrínsecos asociados a poblaciones fúngicas micotoxigénicas de granos de maíz (Zea mays L.) almacenados en silobolsas en Argentina","resumen":"Abstract  In order to determine the behavior of mycotoxin-producing fungal populations linked with silobags stored corn grains, 540 samples taken in three times over a period of five months of storage (beginning, 90 days, final) were evaluated.The fungal biota was identified and quantified. The contamination with fumonisin and aflatoxin was determinate. The effects of extrinsic factors (environment), intrinsic factors (grains) and technological factors (location of the grains in the profile of silobag) were evaluated taking into account the presence and quantity of total and mycotoxigenic populations. The pH of grains and O2 levels were significantly reduced after five months, while CO2 concentration increased in the same period. The total counts of mycobiota were significantly higher in grains located in the top layer of silobag. Mycotoxigenic species of Fusarium spp., Aspergillus spp., Penicillium spp. and Eurotium spp. were identified. The frequency of isolation of Fusarium verticillioides decreased at the end of storage and Aspergillus flavus was isolated only at the beginning of storage. The counts of the Penicillium spp. and Eurotium spp. were increased at the end of storage. The 100% of the samples was contaminated with Fumonisin with maximum levels of 5.707 µg\/kg, whereas Aflatoxin contaminated the 40% of them with maximum levels of 0,8 µg\/kg. The environmental and substrate conditions generated during the storage limited the development of mycotoxigenic fungi and mycotoxin production.","palabras_clave":"MAIZ|HONGOS|SILOBOLSA|ATMOSFERAS AUTOMODIFICADAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17778,"idioma_id":4,"titulo":"OXER1 REGULATES ANGIOTENSIN II AND CAMP-STIMULATED STEROID PRODUCTION IN HUMAN H295R ADRENOCORTICAL CELLS","resumen":"steroid production in human H295R adrenocortical cells.","palabras_clave":"RECEPTOR|ESTEROIDOGENESIS|LEUCOTRIENOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17779,"idioma_id":4,"titulo":"Environmental niche overlap between common and dusky dolphins in North Patagonia, Argentina","resumen":"Research on the ecology of sympatric dolphins has increased worldwide  in recent      decades. However, many dolphin associations such as that between common  dolphins      (Delphinus delphis) and dusky dolphins (Lagenorhynchus obscurus) are  poorly      understood. The present study was conducted in the San Matías Gulf  (SMG)      ecosystem (North Patagonia, Argentina) where a high diet overlap among  both species      was found. The main objective of the present work was to explore the  niche overlap of      common and dusky dolphins in the habitat and temporal dimensions. The  specific aims      were a) to evaluate the habitat use strategies of both species through  a comparison of      their group attributes (social composition, size and activity), and b)  to evaluate their      habitat preferences and habitat overlap through Environmental Niche  modeling      considering two oceanographic seasons. To accomplish these aims, we  used a historic      database of opportunistic and systematic records collected from 1983 to  2011.      Common and dusky dolphins exhibited similar patterns of group size  (from less than 10      to more than 100 individuals), activity (both species use the area to  feed, nurse and      copulate), and composition (adults, juveniles, and mothers with calves  were observed      for both species). Also, both species were observed travelling and  feeding in mixedspecies groups. Specific overlap indices were higher for common  dolphins than for dusky dolphins, but all indices were low, suggesting that  they are mainly segregated in the habitat dimension. In the case of common  dolphins, the best habitats were located      in the northwest of the gulf far from the coast. In the warm season  they prefer areas      with temperate sea surface and in the cold season they prefer areas  with relatively      high variability of sea surface temperature. Meanwhile, dusky dolphins  prefer areas      with steep slopes close to the coast in the southwestern sector of the  gulf in both      seasons.","palabras_clave":"Delphinus delphis|Enviromental niche models|Lagenorhynchus obscurus|Maxent"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17780,"idioma_id":5,"titulo":"EL DERECHO AL ACCESO A LA EDUCACION DE LAS PERSONAS CON DISCAPACIDAD EN EL CONTEXTO DE LAS POLITICAS DE INCLUSION. SU EFECTIVIDAD","resumen":"Dentro del abanico de derechos con jerarquía constitucional es trascendente la tutela que debe dispensarse al grupo humano vulnerable que constituyen las 'personas con capacidades diferentes o personas con discapacidad para lograr su 'inclusión' integral a la sociedad; ello tiene su marco en los principios enunciados por la Convención sobre los Derechos de las Personas con Discapacidad -aprobada en diciembre de 2006 por la Asamblea General de Naciones Unidas e incorporada en el derecho argentino por ley 26378 (2008)-. Estimamos fundamental, par que se logre este objetivo de la inclusión integral a la sociedad de las personas con discapacidad, enfocar la cuestión desde el ángulo de la educación. Ello nos motivó a indagar si las normas y programas educativos creados con tales perspectivas gozan de validez formal y material, para luego comprobar su eficacia.","palabras_clave":"Acceso|Educación|Discapacidad|Inclusión"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17781,"idioma_id":4,"titulo":"Recognition of saccharides in the NIR region with  a novel fluorogenic boronolectin: in vitro and live  cell labeling","resumen":"This work describes a novel mono-boronic acid derivative of a tricarbocyanine. The probe is a genuine near-infrared fluorescence emitter with improved properties such as a large Stokes shift, excellent water solubility and sensitive fluorogenicity upon binding to carbohydrates under physiological conditions.","palabras_clave":"sondas fluorescentes|derivados borónicos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17782,"idioma_id":4,"titulo":"Influence of magnification on extraction efficiency in laser resonators with non-overlapping beams","resumen":"p { margin-bottom: 0.21cm; direction: ltr; color: rgb(0, 0, 0); widows: 2; orphans: 2; }p.western { font-family: 'Sabon','Courier New'; font-size: 11pt; }p.cjk { font-family: 'Times New Roman',serif; font-size: 11pt; }p.ctl { font-family: 'Sabon','Courier New'; font-size: 10pt; }a:link { color: rgb(0, 0, 255); }a:visited { color: rgb(128, 0, 128); }a.western:visited {  }a.cjk:visited {  }a.ctl:visited {  }a.sdfootnotesym-western { font-family: 'Times New Roman',serif; font-size: 11pt; }a.sdfootnotesym-cjk { font-size: 11pt; }a.sdfootnotesym-ctl { font-family: 'Times New Roman',serif; font-size: 11pt; }        The  magnification and the Fresnel number determine the mode profile and  losses in a bare unstable resonator. Upon inclusion of gain, both the  beam pattern and the reflectivity are changed, more than in a stable  cavity, because the counter-propagation intensities differ spatially  and saturate the amplifier in a way that alters the mode profile, the  reflectivity and the conditions of optimal operation. In this paper  we present a numerical study of two types of cavities and compute the  mode profile and losses in presence of an amplifier that saturates  homogeneously. We compare these results with experimental data  obtained on a TEA CO2 laser.","palabras_clave":"LASER RESONATOR|Extraction efficiency|TEA CO2 laser"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17783,"idioma_id":4,"titulo":"Osmotic dehydrated raspberries: Changes in physical aspects and bioactive compounds.","resumen":"Raspberries are very labile fruits that have a short postharvest life; therefore, there is a need to develop alternative storage and processing methods for extending their shelf-life. The effect of wet (WI) and dry (DI) sucrose infusions (aw = 0.85) on color and bioactive compounds of raspberries has been studied. Additives were included: citric acid, sodium bisulfite, or both. Moisture content decreased from 85% (w\/w) for control fruit to approximately 51% (w\/w) for infused samples. The shrinkage of fruits was approximately 27% and 46% after WI and DI, respectively. No major color changes occurred, except for WI-bisulfite treatment. Although the total polyphenols and anthocyanin content were significantly reduced in fruits during osmotic dehydration, mainly due to the dilution effect to the medium, 100 g serving of processed raspberries would supply, in some cases, over 50% of polyphenols provided by a glass of wine. The proposed infusion dehydration methods may be considered an alternative to produce shelf-stable products based on raspberries, with an improved quality in terms of appearance.","palabras_clave":"BIOACTIVE COMPOUNDS|RASPBERRY|COLOR|SUGAR INFUSION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17784,"idioma_id":5,"titulo":"Términos de uso frecuente en producción y utilización de pasturas","resumen":"El objetivo del presente glosario es facilitar el acceso a una definición simple y concisa de los principales términos utilizados en la disciplina Producción y utilización de pasturas. Se presenta un catálogo de los términos más relevantes y los conceptos de mayor consenso, surgidos de la literatura y la admisión internacional, con su equivalente en inglés y con la identificación, asimismo, de aquellos de uso impreciso o incorrecto.","palabras_clave":"GLOSARIO|FORRAJES|PASTOREO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17785,"idioma_id":5,"titulo":"ELECTROBIORREMEDIACIÓN DE UN SUELO CON UNA CONTAMINACIÓN ANTIGUA DE HIDROCARBURO","resumen":"La electrobiorremediación es la técnica híbrida que suma los efectos de la electrorremediación a la degradación bacteriana de diferentes contaminantes. El objetivo de este estudio fue utilizar esta técnica para aumentar la biodisponibilidad de los hidrocarburos presentes en un suelo con contaminación antigua y su eliminación. El experimento duró 63 días y se realizó en una cuba de vidrio con tres compartimentos comunicados por puentes salinos de buffer fosfato que permitieron establecer la diferencia de voltaje y mantener el pH del suelo en valores óptimos para la vida bacteriana. Se determinaron: pH,  humedad, hidrocarburos totales del petróleo (TPH) y bacterias. Los resultados mostraron una disminución de los hidrocarburos siendo la región del cátodo la que mejor eliminó los hidrocarburos, con solo el 9,4 % y 5,46 % de los hidrocarburos alcanos y poliaromáticos; en la celda control estos valores fueron del 15,28 y 14,4 % respectivamente, mientras que el centro fue el lugar que menor degradación presentó quedando el 19,49 % y el 17,88 % de los hidrocarburos alcanos y PAH. Concluimos que los resultados de laboratorio indican la posibilidad de incrementar la biodegradación en suelos con tratamientos biológicos previos.","palabras_clave":"electrobioremediación"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17786,"idioma_id":4,"titulo":"Modeling water uptake by a root system growing in a fixed soil volume","resumen":"The   water uptake by roots of plants is examined for an ideal situation, with   an approximation that resembles plants growing in pots, meaning that   the total soil volume is fixed. We propose a coupled water uptake?root   growth model. A one-dimensional model for water flux and water uptake by   a root system growing uniformly distributed in the soil is presented,   and the Van Genuchten model for the transport of water in soil is used.   The governing equations are represented by a moving boundary model for   which the root length, as a function of time, is prescribed. The   solution of the model is obtained by front-fixing and finite element   methods. Model predictions for water uptake by a same plant growing in   loam, silt and clay soils are obtained and compared. A sensitivity   analysis to determine relative effects on water uptake when system   parameters are changed is also presented and shows that the model and   numerical method proposed are more sensitive to the root growth rate   than to the rest of the parameters. This sensitivity decreases along   time, reaching its maximum at 30&nbsp;days. A comparison of this model with a   fixed boundary model with and without root growth is also made. The   results show qualitative differences from the beginning of the   simulations, and quantitative differences after 10&nbsp;days of simulations.","palabras_clave":"moving boundary|Water uptake|plant root growing"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17787,"idioma_id":5,"titulo":"Metodología para la Delimitación de las Áreas de Riesgo Hídrico en la Provincia de Santa Fe","resumen":"La Ley Nº 11730 de la Provincia de Santa Fe regula el uso de suelos en áreas inundables con el objeto de reducir los efectosnegativos de las inundaciones. La implementación de esta Norma requiere la delimitación de las zonas con diferentesfrecuencias de inundación.En este trabajo se desarrolló una metodología que permitió el trazado preliminar de las áreas de riesgo hídrico en veintiúnsistemas hídricos de Santa Fe, abarcando prácticamente todo el territorio provincial. El procedimiento se basó en lademarcación en plataforma SIG de las áreas anegadas observadas en imágenes satelitales Landsat, conjuntamente con laaplicación de criterios edafológicos y geomorfológicos. El estado hídrico del sistema para la fecha de la imagen y larecurrencia asociada se analizó previamente mediante estudios hidrológicos de las variables hidrometeorológicas. Las áreasinundadas trazadas a partir de las imágenes se contrastaron y completaron con las determinadas con criterios edafológicos apartir de información sobre limitaciones de drenaje, hidromorfismo, salinidad y sodicidad. Estas tareas permitieron definiruna técnica para el trazado de las áreas inundables aplicable a las zonas donde no se contó con información satelital para lasrecurrencias de interés.","palabras_clave":"INUNDABLE|IMAGEN SATELITAL|CRITERIOS EDAFOLOGICOS|SIG"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17788,"idioma_id":4,"titulo":"MINLP Model for the Detailed Scheduling of Refined Products Pipelines with Flow Rate Dependent Pumping Costs","resumen":"Multiproduct pipelines transport fuels from refineries to distant distribution terminals in batches. Theenergy needed to move the fluids through the pipeline is mainly associated with elevation gradients and friction head loss. Commonly, friction loss is the major term requiring pump stations to keep the flow mov-ing, and it is strongly dependent on the fluid flow rate. Some studies have been carried out for reducingthe pumping costs in multiproduct pipelines, but none of them has been focused on thoroughly consider-ing the head loss due to friction along the pipeline. This paper introduces a novel MINLP continuous-timeformulation for the detailed scheduling of single-source pipelines, rigorously tracking power consump-tion at every pipeline segment through nonlinear equations. Real-world case studies are successfullysolved using GAMS?DICOPT algorithm, which proves to be a useful tool for solving large-scale, nonlinearscheduling problems. Important reductions in the operation costs are achieved by keeping a more stableflow rate profile over the planning horizon.","palabras_clave":"Multiproduct pipeline|Detailed scheduling|MINLP approach|Friction head loss|DICOPT solver"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17789,"idioma_id":4,"titulo":"Trypanothione reductase inhibitors: Overview of the action of thioridazine in different stages of Chagas disease","resumen":"tThioridazine (TDZ) is a phenothiazine that has been shown to be one of the most potent phenothiazinesto inhibit trypanothione reductase irreversibly. Trypanothione reductase is an essential enzyme for thesurvival of Trypanosoma cruzi in the host. Here, we reviewed the use of this drug for the treatment of T.cruzi experimental infection. In our laboratory, we have studied the effect of TDZ for the treatment ofmice infected with different strains of T. cruzi and treated in the acute or in the chronic phases of theexperimental infection, using two different schedules: TDZ at a dose of 80 mg\/kg\/day, for 3 days starting1 h after infection (acute phase), or TDZ 80 mg\/kg\/day for 12 days starting 180 days post infection (d.p.i.)(chronic phase). In our experience, the treatment of infected mice, in the acute or in the chronic phases ofthe infection, with TDZ led to a large reduction in the mortality rates and in the cardiac histological andelectrocardiographical abnormalities, and modified the natural evolution of the experimental infection.These analyses reinforce the importance of treatment in the chronic phase to decrease, retard or stopthe evolution to chagasic myocardiopathy. Other evidence leading to the use of this drug as a potentialchemotherapeutic agent for Chagas disease treatment is also revised.","palabras_clave":"Tioridazine|Trypanotione reductase|Chagas disease chemotherapy|Trypanosoma cruzi strains"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17790,"idioma_id":4,"titulo":"TAPHONOMIC SIGNATURES IN CONCENTRATIONS OF HELEOBIA STIMPSON, 1865 FROM HOLOCENE DEPOSITS OF THE SALADO RIVER BASIN, BUENOS AIRES, ARGENTINA: THEIR UTILITY IN PALEOENVIRONMENTAL RECONSTRUCTIONS","resumen":"Assemblages composed of Heleobia parchappii and H. australis constitute the dominant elements in Quaternary deposits of the Pampean Region in the province of Buenos Aires. This study describes and analyzes the degree of preservation of shells of both species recovered from nine Holocene localities in order to describe and quantify taphonomic alterations, evaluate if preservation varied during the Holocene, and assess their utility as paleoenvironmental bioindicators. Heleobia parchappiidisplayed better overall preservation than H. australis, with little evidence of fragmentation, limited principally to levels with highest densities. On a temporal scale, no significant differences in fragmentation were found, whereas corrasion and lusterdisplayed temporal differences.","palabras_clave":"Heleobia parchappii | Heleobia australis|Salado river|Holocene"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17791,"idioma_id":4,"titulo":"Ab Initio Study Of The Ferromagnetic Response, Local Structure And Hyperfine Properties Of Fe Doped SnO2","resumen":"ABSTRACT: We present here an ab initio study of the  structural, magnetic, and hyperfine properties of Fe-doped  rutile SnO2 for different concentrations and distributions of  the Fe atoms and oxygen vacancies in the SnO2 host. The  calculated results are compared with experimental ones  obtained by Mo&#776;ssbauer spectroscopy and X-ray absorption  techniques. This comparison enables us to characterize the  local structure around Fe atoms and to identify the different  hyperfine interactions that are observed in samples prepared  by different methods. It is concluded that oxygen vacancies are  fundamental for the ferromagnetic response of Fe-doped SnO2. The ab initio calculations show that two Fe ions sharing an  oxygen vacancy are coupled ferromagnetically, forming a bound magnetic polaron (BMP), and that two neighbor BMPs are  aligned antiparallel to each other. Electron doping plays a fundamental role mediating the magnetic coupling between the BMP  inducing ferromagnetic alignment between the BMPs.","palabras_clave":"DILUTED SEMICONDUCTOR OXIDES|MAGNETIC PROPERTIES|AB-INITIO CALCULATIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17792,"idioma_id":5,"titulo":"Advances in methods to obtain and characterise room temperature magnetic ZnO","resumen":"We report the existence of magnetic order at room temperature in Li-doped ZnO microwires after low energy H+ implantation. The microwires with diameters between 0.3 and 10m were prepared by a carbothermal process. We combine spectroscopy techniques to elucidate the influence of the electronic structure and local environment of Zn, O and Li and their vacancies on the magnetic response. Ferromagnetism at room temperature is obtained only after implanting H+ in Li-doped ZnO. The overall results indicate that low-energy proton implantation is an effective method to produce the necessary amount of stable Zn vacancies near the Li ions to trigger the magnetic order.","palabras_clave":"MAGNETISM|ZnO|SEMICONDUCTORS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17793,"idioma_id":4,"titulo":"Time course of adipose tissue dysfunction associated with  antioxidant defense ,inflammatory cytokines and oxidative stress in dyslipemic insulin resistant rats","resumen":"The dysfunctional adipose tissue of rats fed a sucrose-rich diet was investigated following the time course  of the development of oxidative stress, changes in proinflammatory cytokines and adiponectin levels, and  their relationship with insulin resistance. We analyzed the morphometric characteristics of epididymal adipocytes,  de novo lipogenesis enzyme activities and cellular antioxidant defense, inflammatory mediators,  adiponectin levels and insulin resistance in rats fed a sucrose-rich diet for 3, 15 or 30 weeks and compared  to those fed a control diet. The results showed a depletion of antioxidant enzyme activities in the  fat pads of rats fed a sucrose-rich diet, with an increase in xanthine oxidase activity and lipid peroxidation  after 3, 15 and 30 weeks on the diet. Superoxide dismutase activity and the redox state of glutathione  showed a significant decrease at weeks 15 and 30. This was accompanied by visceral adiposity and  enhanced lipogenic enzyme activities. An increase in the plasma levels of proinflammatory markers  (TNF-&#945; and IL-6) was recorded only after 30 weeks on the diet. A reduction in plasma adiponectin levels  accompanied the time course of deterioration of whole-body insulin sensitivity. The results suggest that  lipid peroxidation, depletion of antioxidant defenses and changes in inflammatory cytokines induced by a  sucrose-rich diet contribute to the dysregulation of adipose tissue and insulin resistance. Finally, these  results show that the progressive deterioration of adipose tissue function, which begins in the absence of  both visceral adiposity and overweight, is highly dependent on the length of time on the diet.","palabras_clave":"ADIPOSE TISSUE|OXIDATIVE STRESS|RATS|SUCROSE RICH DIET"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17794,"idioma_id":4,"titulo":"Surface studies on graphite furnace platforms covered with   Pd, Rh and Ir as modifiers in graphite furnace atomic absorption spectrometry of tellurium,","resumen":"The main objective of this work is the study of correlations between the   efficiency of the distribution of the permanent platinum group   modifiers Pd, Rh and Ir over the graphite surface with the aim of   improving analytical signal of tellurium.Modifier solution was deposited onto the platform and pyrolysed after   drying. In the case of Pd, the physical vaporization\/deposition   technique was also tested.In order to analyze the differences amongst coverings (morphology,   topology and distribution), the graphite surfaces were studied with   scanning electron microscopy and energy dispersive X ray microscopy.Micrographs for physical vaporization and pyrolytic deposition of Pd   were also analyzed in order to explain the lack of signal obtained for   tellurium with the first alternative. Similar micrographs were obtained   for pyrolytic deposition of Ir and Rh and then, compared to those of Pd.   Ir showed the most homogeneous distribution on the graphite surface and   the tallest and sharpest transient. With the aim of improving the analytical signal of tellurium, the   correlation between the surface studies and the tellurium transient   signal (height, area and shape) are discussed.","palabras_clave":"MODIFIERS|SCANNING ELECTRON MICROSCOPY |ENERGY DISPERSIVE X RAY MICROSCOPY|GRAPHITE FURNACE|TELLURIUM SIGNAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17795,"idioma_id":4,"titulo":"Specific growth rate observer for the growing phase of a Polyhydroxybutyrate production process","resumen":"This paper focuses on the specific growth rate estimation problem in a Polyhydroxybutyrate bioplastic production process by industrial fermentation. The kinetics of the process are unknown and there are uncertainties in the model parameters and inputs. During the first hours of the growth phase of the process, biomass concentration can be measured online by an optical density sensor, but as cell density increases this method becomes ineffective and biomass measurement is lost. An asymptotic observer is developed to estimate the growth rate for the case without biomass measurement based on corrections made by a pH control loop. Furthermore, an exponential observer based on the biomass measurement is developed to estimate the growth rate during the first hours, which gives the initial condition to the asymptotic observer. Error bounds and robustness to uncertainties in the models and in the inputs are found. The estimation is independent of the kinetic models of the microorganism. The characteristic features of the observer are illustrated by numerical simulations and validated by experimental results.","palabras_clave":"Bioplastics|Observer|Estimation|PHB|Software sensor"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17796,"idioma_id":4,"titulo":"Immune Defenses of the Invasive Apple Snail Pomacea canaliculata (Caenogastropoda, Ampullariidae): Phagocytic Hemocytes in the Circulation and the Kidney","resumen":"Hemocytes in the circulation and kidney islets, as well as their phagocytic responses to microorganisms and fluorescent beads, have been studied in Pomacea canaliculata, using flow cytometry, light microscopy (including confocal laser scanning microscopy) and transmission electron microscopy (TEM). Three circulating hemocyte types (hyalinocytes, agranulocytes and granulocytes) were distinguished by phase contrast microscopy of living cells and after light and electron microscopy of fixed material. Also, three different populations of  circulating hemocytes were separated by flow cytometry, which corresponded to the three hemocyte types. Hyalinocytes showed a low nucleus\/cytoplasm ratio, and no apparent granules in stained material, but showed granules of moderate electron density under TEM (L granules) and at least some L granules appear acidic when labeled with LysoTracker Red. Both phagocytic and non-phagocytic hyalinocytes lose most (if not all) L granules when exposed to microorganisms in vitro. The phagosomes formed differed whether hyalinocytes were exposed to yeasts or to Gram positive or Gram negative bacteria. Agranulocytes  showed a large nucleus\/cytoplasm ratio and few or no granules. Granulocytes  showed a low nucleus\/cytoplasm ratio and numerous eosinophilic granules after staining.These granules are electron dense and rod-shaped under TEM (R granules). Granulocytes may show merging of R granules into gigantic ones, particularly when exposed to microorganisms.Fluorescent bead exposure of sorted hemocytes showed phagocytic activity in hyalinocytes, agranulocytes and granulocytes, but the phagocytic index was significantly  higher in hyalinocytes.Extensive hemocyte aggregates (?islets?) occupy most renal hemocoelic spaces and hyalinocyte-like cells are the most frequent component in them. Presumptive glycogen deposits were observed in most hyalinocytes in renal islets (they also occur in the circulation  but less frequently) and may mean that hyalinocytes participate in the storage and circulation of this compound. Injection of microorganisms in the foot results in phagocytosis by hemocytes in the islets, and the different phagosomes formed are similar to those in circulating hyalinocytes. Dispersed hemocytes were obtained after kidney collagenase digestion and cell sorting, and they were able to phagocytize fluorescent beads. A role for the kidney as an immune barrier is proposed for this snail.","palabras_clave":"Gastropod immunology|apple snail biology|Ampullariidae|invasive species|flow cytometry|transmission electron microscopy|confocal laser scanning microscopy|Angiostrongylus cantonensis|rat lung worm|eosinophilic meningitis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17797,"idioma_id":4,"titulo":"Hematology, Biochemistry and Serum Protein Analyses of Antarctic and non-Antarctic Skuas","resumen":"Abstract.?Determination of hematological and biochemical parameters provides important data to assess the physiological condition in wild birds. Therefore, to carry out ecophysiology or conservation studies it is essential toestablish baseline physiological parameters and how these change with age and life history events. Hematological (hematocrit, hemoglobin and erythrocyte sedimentation) and biochemical (glucose, total lipids and proteins, aspartateand alanine aminotransferase activities and electrolyte concentration) reference values were determined in two Antarctic migratory bird species, the Brown Skua (Stercorarius antarcticus) and South Polar Skua (S. maccormicki),from South Shetland Island during breeding season. Also, hematological data (hematocrit) were determined for non-Antarctic skuas, with Chilean (S. chilensis) and Falkland (S. antarcticus antarcticus) skuas sampled in the BeagleChannel islands (Tierra del Fuego Province) and Viana Island (Chubut Province), Argentina, respectively. Differences between adult Antarctic skua species were observed in hemoglobin, erythrocyte sedimentation, total lipidsand aspartate aminotransferase activity. In addition, age-related differences in Antarctic skuas in hematocrit, hemoglobin, glucose and total protein values were observed. Serum reference protein fractions (Albumin, &#945;1, &#945;2, &#946; and &#947; globulins) were assessed by electrophoresis for Antarctic and non-Antarctic skuas. Similar protein patterns were observed between South Polar and Chilean skuas as well between Falkland Skua and Brown Skua. The differences between adult sympatric Antarctic skuas may be related to their nutritional status and species-specific migrations, feeding habits and the differential use of the breeding niches, while the age variation may be related to physiological development processes in chicks or to the energy expenditure in adults during breeding. Received 28 June 2014,accepted 14 January 2015.Key words.?Antarctic, biochemistry, hematology, protein electrophoresis, skuas.Waterbirds 38(2): 153-161, 2015","palabras_clave":"Hematology|Antarctic skuas|Non-antarctic skuas|Serum proteins"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17798,"idioma_id":4,"titulo":"Radon   transform-based microseismic event detection and signal-to-noise ratio enhancement","resumen":"We present an adaptive filtering method to denoise downhole microseismic data. The methodology uses the apex-shifted parabolic Radon transform. The algorithm is implemented in two steps. In the first step we apply the apex-shifted parabolic Radon transform to the normalized root mean square envelope of the microseismic data to detect the presence of an event. The Radon coefficients are efficiently calculated by restricting the integration paths of the Radon operator. In a second stage, a new (preconditioned) Radon transform is applied to individual components to enhance the recorded signal. The denoising is posed as an inverse problem preconditioned by the Radon coefficients obtained in the previous step. The algorithm was tested with synthetic and field datasets that were recorded with a vertical array of receivers. The method performs rapidly due to the parabolic approximation making it suitable for real-time monitoring. The P? and S?wave direct arrivals are properly denoised for high to moderate signal-to-noise ratio records.","palabras_clave":"Radon transform|Microsesismic|Denoising|Detection"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17799,"idioma_id":4,"titulo":"New Insights on the Structure of the Picloram- Montmorillonite Surface Complexes","resumen":"Hypothesis: The environmental mobility and bioavailability of Picloram (PCM) are determined by the  amine and carboxylate chemical groups interaction with the soils mineral phases. Clay particles, such  as montmorillonite (Mt), and the pH value of the media could play an important role in adsorption  processes. Thus, the study of the role of soil components other than organic matter deserves further  investigation for a more accurate assessment of the risk of groundwater contamination.  Experiments: Samples with PCM adsorbed on Mt dispersions were prepared at pH 3?9. Subsequently, the  dispersions were separated, washed, centrifuged and stored at room temperature. Picloram (PCM)  herbicide interaction with surface groups of montmorillonite (Mt) was studied using XRD, DTA, FTIR  and XPS techniques.  Findings: The entrance of PCM into the Mt basal space, in two different arrangements, perpendicular and  planar, is proposed and the final arrangement depends on PCM concentration. The interaction of PCM  with Mt surface sites through the nitrogen of the pyridine ring and carboxylic group of PCM, forming  bidentate and bridge inner-sphere complexes was confirmed by FTIR and XPS analysis. The acidity  constant of the PCM adsorbed on the Mt surface was calculated","palabras_clave":"picloram |montmorillonita|complejos superficiales|minerales arcillosos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17800,"idioma_id":4,"titulo":"Synthesis and Characterization of Vinyltrimethoxysilane-Grafted Non-Swelling Clay","resumen":"The structural characteristics as well as the binding capacity of the functionalized halloysite\/kaolinite from north Patagonia, Argentina were investigated. The sample was modified by immobilization of ligands containing vinyl (C=C) groups by covalent grafting with surface silanol groups.  Silane grafted non swelling clays were synthesized by using vinyltrimethoxysilane (VTMS) via two different grafting reaction systems: (a) ethanol-water mixture and (b) xylene mixture. The resulting products were investigated using Infrared Spectroscopy (IR), X-ray diffraction (XRD), Thermogravimetric analysis (TGA-DTA), Microanalysis by dispersive energy (EDX) and Contact Angle for water (&#966;). The results indicate that the vinyl groups grafted at the mineral edges changed the hydrophilic nature of the clay mineral into hydrophobic. X-ray diffraction showed that their original structure had been preserved.","palabras_clave":"HALLOYSITE|KAOLINITE| VTMS|GRAFTING|SURFACE MODIFICATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17801,"idioma_id":4,"titulo":"Expression and functional characterization of a C-7 cholesterol desaturase from Tetrahymena thermophila in an insect cell line","resumen":"Tetrahymena thermophila transforms exogenous cholesterol into pro-vitamin D3 (7-dehydrocholesterol) with remarkable efficiency in a one-step reaction carried out by a C-7 cholesterol desaturase. The enzyme DES7 is encoded by the gene TTHERM_00310640, identified with RNAi and gene knock-out experiments, but has not yet been heterologously expressed actively in any organism. A model derived from its amino acid sequence classified DES7p as a Rieske-type oxygenase with transmembrane localization. The protein has catalytic activity, sequence and topological similarity to DAF-36\/Neverland proteins involved in the synthesis of steroid hormones in insects and nematodes. Due to their structural and functional similarity, we analyzed the expression of a codon optimized DES7 gene from Tetrahymena in the insect Sf9 cell line, identified and measured the steroid metabolites formed, and extended the actual knowledge on its localization. We found that the accumulation of 7-dehydrocholesterol could be increased 16-40-fold in Spodopterafrugiperda, depending on physiological conditions, by overexpression of T. thermophila DES7. The protein was detected in the microsomal fraction, in accordance with previous reports. Although the electron transfer chain for Des7p\/DAF-36\/Neverland Rieske-type oxygenases is presently unknown, we identified possible donors in the ciliate and insect genomes by bioinformatic analysis. In spite of the large evolutionary distance between S. frugiperda and T. thermophila, the results indicate that there is significant functional conservation of the electron donors, since the ciliate´s sterol desaturase can function in the context of the insect electron transport system. The results achieved demonstrate that DES7 is the first gene from a ciliate, coding for a microsomal enzyme, expressed in active form in an insect cell line.","palabras_clave":"Tetrahymena|Sterol desaturase|Provitamin D3|Spodoptera frugiperda"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17802,"idioma_id":4,"titulo":"Aggregation agents and structural stability in soils with different texture and organic carbon","resumen":"The flat pampas of the Santa Fe State in Argentina have soils with high silt content, variable carbon content, and diverse degrees of structural degradation. Aggregate stability has been used as an indicator of the structural condition of the soil. The aim of this study was to quantify the effect of the addition of crop residues and root activity on the agents of aggregation and mechanisms of aggregate breakdown in soils with different carbon contents and textures cultivated under no-till. For this purpose an experimental F trial was conducted on a loam soil (Typic Hapludoll) and a silty soil (Typic Argiudoll) o under controlled conditions for 112 days with the following treatments: (i) with and without wheat plant growth and (ii) with and without addition of wheat residues. Soil structural R stability by a method allowing differentiation of aggregate breakdown by slaking, by mechanical effect and microcracking, total organic carbon content, particulate organic  carbon, glomalin and carbohydrate fractions were eassessed. In general, the addition of residues and the presence of plant with active roots increased the presence of all aggregation agents and decreased aggregate breakdown processes in both soils. Soluble carbohydrates and O proteins related to glomalin were the most important aggregating agents and their function was to reduce the magnitude of breakdown mechanisms, slaking and microcracking, evidencing a greater impact on the silty soil.","palabras_clave":"glomalin|carbohydrates |crop residues|active roots"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17803,"idioma_id":4,"titulo":"Bioavailability and Antioxidant Effect of the Ilex Paraguariensis Polyphenols","resumen":"Purpose ? The purpose of this study was to evaluate in vivo the bioavailability of the Ilex paraguariensis polyphenols due to total polyphenols and changes in antioxidant capacity (AOC) in human plasma after an acute intake of 300 ml of an infusion of yerba maté (YM) for 120 minutes. Also, we evaluated the variation of plasma protein or plasma uric acid after the acute intake of YM infusion.  Design\/methodology\/approach ? Seventeen healthy young volunteers participated in the determining plasma of total polyphenols concentration (TPC, Folin-Ciocalteu method), plasma AOC for ferric reducing antioxidant power (FRAP) and 2,2=-azinobis-3-ethylbenzothiazoline-6-sulfonic acid diammonium salt [ABTS] methods), plasmatic uric acid and plasma total protein over the 120 minutes test.  Findings ? It was found that the bioavailability of YM polyphenols during 120 minutes was 49.3 +\/-11.9 per cent, the TPC was increased to 6.0 +\/-1.5 per cent, the plasmaAOCwas increased byFRAP8.3 +\/-3.3 per cent and byABTS 6.0 +\/- 2.0 per cent and no significant variation of plasma protein or plasma uric acid was found.  Practical implications ? Maté polyphenols has a thrifty effect on the natural antioxidant defenses of the body, which are beneficial to human health.  Originality\/value ? There was no information on the bioavailability of polyphenols in YM infusions prepared in its traditional form as ?hot mate?.","palabras_clave":"Antioxidant capacity|Human plasma|Ilex paraguariensis| Polyphenol bioavailability"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17804,"idioma_id":4,"titulo":"In vitro evaluation of synergistic activity between ciprofloxacin and broad snouted caiman serum against Escherichia coli","resumen":"The in vitro synergistic activity between ciprofloxacin and serum of broad snouted caiman on Escherichiacoli was studied. The estimated MIC value of ciprofloxacin was 0.0188 &#956;g\/ml, and two assays of killcurve during 5 hours were performed: the first one in a standard culture medium and the second onein the presence of caiman serum. Different concentrations of ciprofloxacinwere tested. Ciprofloxacin showedhigher values of bacterial elimination rate in the presence of caiman serum in all concentrations tested.The combined activity of sub-inhibitory concentrations of ciprofloxacin and the humoral immune factorspresent in caiman serum determined an increase in the bacterial elimination observed in this assay.Wesuggest that the antibacterial activity of complement and natural antibodies present in caiman serum,which can bind to both Gram-negative and Gram-positive bacteria and acting through the classical complementpathway, can inhibit bacterial growth of Escherichia coli by lysis.","palabras_clave":"CIPROFLOXACIN|ESCHERICHIA COLI|CAIMAN SERUM|SYNERGISM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17805,"idioma_id":4,"titulo":"Relationship between the Electrogalvanized Stages and the Income of Hydrogen in a  Low Carbon Wire Steel","resumen":"Hydrogenation of steel products in the electrochemical processes occurs to some extent in all stages of coating. The decisive contribution in the hydrogenation of steel is galvanized by itself, however, the influence of preliminary operations like degreasing and pickling also are considered as sources of hydrogen embrittlement. In the literature, numerous previous studies are aimed on the effect of deformation on the corrosion behavior of zinc coating, however limited to the specific treatment of corrosion properties leaving aside the possible hydrogen trapping. Embrittlement can occur when hydrogen is released during etching process, absorbed by the steel and being trapped at the grain boundaries, dislocations, interfaces inclusion \/ matrix, etc. Normally, at galvanizing temperatures, hydrogen is expelled from steel. But, in some cases as in electrogalvanizing, hydrogen is absorbed in the steel. This paper aims to assess the main variables in the pickling and electrogalvanizing in order to optimize the coating procedure which avoids the possible hydrogen entry into the steel. Besides, some thermal properties of the coatings obtained are discussed.","palabras_clave":"ELECTROGALVANISED|PICKLING|RUGOSITY|COATING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17806,"idioma_id":4,"titulo":"INFLUENCE OF TOTAL STRAIN AMPLITUDE ON HYDROGEN EMBRITTLEMENT OF A HIGH STRENGTH STEEL","resumen":"This study aims at evaluating the influence of fatigue strain range on hydrogen embrittlement of resulfurized high strength steel on low-cycle fatigue tests. Previously, samples were charged with hydrogen (H) under different conditions. The presence of H causes softening effects on the cyclic behavior and a reduction in fatigue life of samples in comparison with uncharged samples. The explanation of this behavior is based on quantitative analyses of fracture surfaces as well as the microstructure by optical microscopy and scanning electron microscopy (SEM). Moreover, enthalpy changes, associated with the main H trapping sites, were determined by differential scanning calorimetry (DSC).This study has enhanced the understanding of the variables that most influence the fatigue behavior of this type of steel charged with hydrogen.","palabras_clave":"EMBRITTLEMENT|HYDROGEN|INCLUSIONS|CRACKS|STEELS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17807,"idioma_id":5,"titulo":"Regulatory Analysis of Distributed Generation installed by Distribution Utilities","resumen":"This paper  presents an analysis of current regulations and global trends regarding the  Distributed Generation (DG) that can be installed by distribution utilities. A  study on the implications of installing DG in distribution networks is  presented, from both perspectives of the utility and the regulator. In  addition, an analysis of the benefits of installing DG from technical, economic  and political points of view is explained. Finally, regulatory recommendations  and general guidelines of a mechanism for encouraging distribution utilities to  invest in DG units are exposed, with the purpose that both the utilities and  the consumers can take advantage of resulting benefits.","palabras_clave":"DISTRIBUTED GENERATION|INVESTMENT DEFERRAL|POWER DISTRIBUTION|REGULATORY FRAMEWORKS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17808,"idioma_id":4,"titulo":"Dynamical effects in the segregation of granular mixtures in quasi 2D piles","resumen":"The dynamics of segregation, mixing and layering is studied during the build-up of quasi-2D piles of two different species of grains of different diameters (i.e. 1 mm glass beads and either 3 mm glass beads or 3.1 mm coriander seeds). The ranges of existence of the different flowregimes are studied as a function of the relative volume flow  rates of the two species and of the drop height; the variation of the mean slope of the pile with time is shown to depend on the flow regime. Complete segregation occurswhen the larger grains are coriander seeds while there is always some mixing for glass beads, although the ratio between the sizes of the particles is the same in both cases. A layered regime is observed for glass beads of same geometry (i.e. spheres) and density but of two different diameters: it is accompanied by variations of large amplitude of the slope of the pile. No layering occurswhen  the large particles are coriander seeds instead of glass beads. The local processes underlying these regimes are analyzed quantitatively fromspatiotemporal diagrams of the profile of the free surface and the characteristic velocities of the different types of displacements of the grains are determined. Avalanches are only observed for glass beads and in the layered regime and play an important part in the development of the layers.","palabras_clave":"GRANULAR|MIXING |SEGREGATION|LAYERING|SPATIOTEMPORAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17809,"idioma_id":4,"titulo":"Tick-borne Rickettsiales: Molecular tools for the study of an emergent group of pathogens","resumen":"The use of molecular techniques in recent years has enhanced the sensitivity and specificity of the diagnosis of Rickettsiales, a bacterial order which includes significant emerging and re-emerging pathogens of humans and animals. Molecular detection enables the accurate identification at the species level, providing additional information on the epidemiology and course of the clinical cases. Moreover, PCR and enzyme restriction analysis of the vector blood meal can be employed to study the tick feeding source and possibly identify pathogen´s reservoir. Here, we review the molecular tools available for the identification and characterization of tick-borne bacteria from the genera Rickettsia, Ehrlichia and Anaplasma and for the study of ticks feeding behavior. We summarize the significant criteria for taxonomic identification of Rickettsiales species and propose a procedure algorithm for the classification of bacterial isolates as members of this order.","palabras_clave":"RICKETTSIA|EHRLICHIA|ANAPLASMA|BLOOD MEAL ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17810,"idioma_id":4,"titulo":"Monte Carlo modelling of particle resuspension on a flat surface","resumen":"A model for the resuspension of a monolayer of particles deposited on a flat surface is developed based on a Monte Carlo simulation of the phenomenon. Particles deposited on the surface are attached to it through an adhesion force. A turbulent flow is assumed to be responsible for the resuspension of particles. The stochastic process used for particle resuspension is based on the evaluation of probabilities depending on the ratio between adhesion and aerodynamic forces and using a Metropolis function. Although simple, the present model accounts for the main features of the resuspension flux observed experimentally and by other models. The model is able to clearly show the role that the parameters of the force distributions (both adhesion and turbulent) have on the short- and long-term resuspension flux, and it captures the intrinsic stochastic nature of the resuspension process.","palabras_clave":"RESUSPENSION|MONTE CARLO SIMULATION|ADHESION|TURBULENCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17811,"idioma_id":5,"titulo":"CORRAL GRANDE 1 Y ARROYO SECO: NUEVOS APORTES AL FORMATIVO DE ANTOFAGASTA DE LA SIERRA (PROVINCIA DE CATAMARCA, PUNA MERIDIONAL ARGENTINA)","resumen":"En la microrregión de Antofagasta de la Sierra (Puna Argentina) se vienen desarrollando desde hace muchos años estudios orientados a la comprensión del proceso sociocultural formativo (ca. 3000-1100 años AP). En recientes actividades de campo se identificaron nuevos sectores arqueológicos, en diversos microambientes de la región, con evidencias asignables a momentos previos a ca. 1100 años AP: Arroyo Seco y Corral Grande 1. El objetivo de este trabajo es presentar estos nuevos hallazgos exponiendo las tendencias observadas en las evidencias cerámicas, líticas y arquitectónicas relevadas hasta el momento para discutirlas en el marco de investigaciones y modelos precedentes.","palabras_clave":"Formativo|microambientes|cerámica|tecnología lítica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17812,"idioma_id":4,"titulo":"Advances in metal-assisted non-electrophilic fluoroalkylation reactions of organic compounds","resumen":"Metal-assisted trifluoromethylation and perfluoroalkylation reactions are probably one of the firstapproachesemployed to achieve fluoroalkyl-group substitutions of organic substrates through the useofmetals such as copper. Fluoroalkylation reactions of both aromatic and aliphatic substrates involv-ingthe employment of perfluoroalkyl halides R f X in conjunction with metallic species, and nucleophilicfluoroalkylatingreagents in the presence of metals or organometallic species will be studied. Fluoroalky-lationreactions utilizing electrophilic fluoroalkylating reagents in the presence of transition metals ortrifluoromethylthiolationreactions will not be the subject of this article. Recently emerging literature(2011?present),with special emphasis on updates from previous review articles on the metal-mediatedfluoroalkylationof aromatic substrates will be dealt with.","palabras_clave":"Metal-assisted trifluoromethylation |Trifluoromethylation by metalorganic species|Fluoroalkylation of aromatics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17814,"idioma_id":4,"titulo":"Peroxidase activity and sensory quality of ready to cook mixed vegetables for soup: combined effect of biopreservatives and refrigerated storage","resumen":"Enzymatic senescence processes and browning of fresh cut vegetables negatively affect their sensory properties and nutritional value and finally result in the rejection of affected products by consumers. In order to prevent quality decay, the combined effects of natural antioxidants and storage temperature on peroxidase activity and sensory attributes (overall visual quality, browning and odor) of individual and mixed vegetables for soup (butternut squash, leek and celery) were evaluated. Fresh cut vegetables were treated with antioxidant solutions as tea tree essential oil (15 &#956;l\/mL), propolis extract (15 &#956;l\/mL) and gallic acid (2 mg\/mL) and stored at optimal (5 °C) and abusive (15 °C) temperature for a maximum of 14 days. The application of natural preservatives, plus optimal storage conditions, exerted significant inhibitory effects in peroxidase activity of squash, celery and mixed vegetables throughout the storage. Furthermore, propolis treatment applied on mixed vegetables retarded browning appearance and preserved the visual quality for a longer period when compared to untreated product. Practical Application: The application of natural antioxidants such as propolis extract in combination with optimal storage conditions may be a good alternative to minimize the possibilities of fresh cut vegetables deterioration and preserve their quality.","palabras_clave":"ready to use vegetables|antioxidants; bioactive compounds|shelf life; preservation technologies| quality changes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17815,"idioma_id":4,"titulo":"Diel vertical distribution of the larvacean Oikopleura dioica in a North Patagonian tidal frontal system (42°?45°S) of the SW Atlantic Ocean","resumen":"In frontal systems, larvaceans generally comprise a significant fraction of the mesozooplankton. Given the low mobility ofthese organisms, their vertical distribution is directly influenced by the physical conditions of the water column. The maingoal of this study was to investigate the day and night vertical distribution of the larvaceans Oikopleura dioica in the differentsectors of the Península Valdés tidal front (42°?45°S; SW Atlantic Ocean), focusing on possible causes such asoceanographic conditions (well-mixed, frontal and stratified), feeding activities, reproductive behaviour and predationrisks. Day and night samples were collected with a MultiNet of 67 &#956;m and 300 &#956;m mesh size, from two depth layers.Conductivity-temperature-depth (CTD) profiles were also recorded. In the well-mixed waters, the size structure of O. dioicawas similar in the upper and lower layers both in the day and night samples, probably due to the continuous verticalmovement caused by the turbulent mixing of waters. In the frontal and stratified areas, mature animals were found in theupper layers during the night, possibly due to their aggregation in surface waters for synchronized spawning. In these areas,a high percentage of well-fed larvaceans was also found. Principal component analysis showed that, at night, the abundanceof potential predators such as chaetognaths, ctenophores and anchovy larvae was correlated with the parameter of stability ofthe water column (Simpson parameter), and that these were more abundant in the upper layers of the stratified areacontaining larvaceans. Our results suggest that the degree of stratification of the water column was the main factor affectingthe vertical distribution of O. dioica.","palabras_clave":"LARVACEANS|OCEANOGRAPHIC CONDITIONS|TIDAL FRONT|VERTICAL DISTRIBUTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17816,"idioma_id":5,"titulo":"Una alternativa para el cálculo de las NBI","resumen":"El estudio de las condiciones de vida de la población requiere la utilización de medidas y herramientas que posibiliten captar los diferentes matices presentes en este tipo de fenómenos. Una delimitación exacta de quienes son pobres y quienes no lo son, a veces no logra mostrar correctamente la realidad. Los sistemas borrosos tienen la capacidad de modelar formas de razonamiento no preciso, que juegan un papel esencial en la habilidad humana para tomar decisiones racionales en entornos de incertidumbre.El empleo de metodología fuzzy en problemas de medición de pobreza hace posible una utilización más eficiente de los recursos y proporciona mayor información al decisor.El objetivo de este trabajo es aplicar el modelo de Necesidades Básicas Insatisfechas Fuzzy a un conjunto de familias rurales de la Provincia de Misiones con el fin de poder clasificar a dichas familias de acuerdo con el grado de insatisfacción de Necesidades Básicas.","palabras_clave":"MEDIDAS DE POBREZA|NBI|MODELOS LINGUISTICOS|MODELO ALTERNATIVO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17817,"idioma_id":5,"titulo":"Caracterización de las Sequías Meteorológicas en la Región Central de la Argentina","resumen":"Los procesos de sequía de distintas intensidades afectan de manera recurrente varias regiones de la República Argentina. Dado el carácter agrícola-ganadero de la región central pampeana de ese país, el análisis y la evaluación de las sequías en dicha región adquiere gran relevancia en el plano económico y en el de la planificación estratégica, entre otros. Esta situación es aún más relevante si se menciona que en tal territorio se localizan algunas de las ciudades más importantes del país. En este trabajo se analiza la variabilidad espacial de las sequías-meteorológicas en la región de estudio mediante el índice estandarizado de precipitaciones (SPI) para subáreas y en el ámbito regional, teniendo en cuenta, además, la influencia del fenómeno climático ENSO. Para identificar subáreas de influencia de los fenómenos de déficit hidrometeorológico, se aplicaron criterios y técnicas estadísticas de análisis sobre la variable lluvia media anual (la cual se adopta a priori como representativa de los procesos que se estudian en este trabajo debido a su mayor disponibilidad espacial y temporal) de 15 localizaciones en la región de estudio. Se utilizaron series de datos pluviométricos mensuales de estaciones ubicadas en las provincias de Córdoba, Santa Fe y Entre Ríos, para el periodo 1980-2009. Se lograron identificar tres grupos de estaciones con comportamiento similar en lo que se refiere a los procesos pluviométricos y, en particular, aquellos relacionados con las sequías intensas, lo que permite identificar escalas espaciales o subáreas de influencia de los fenómenos de déficit hidrometeorológico.","palabras_clave":"region central de la argentina|sequias meteorologicas|analisis multivariado|SPI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17818,"idioma_id":4,"titulo":"Diet and residential mobility in the Argentine Centre West Colony: Stable Isotopes (13c, 15n, 18o) in human bone samples.","resumen":"Change or continuity of the human diet after the Spanish settlement inAmerica is a topic mostly addressed in historical written documents with little useof the archaeological record and bioarchaeological or culture material. To counteractthis weakness, this paper presents a study of the diet in individuals living incentral-western Argentina between the seventeenth, eighteenth, and nineteenthcenturies. The paper, focusing on historical bioarchaeology using stable isotopes(&#948;13C, &#948;15N, &#948;18O) from bone samples of human skeletal remains found inMendoza, Argentina. The aim is to reconstruct the human diet and its residentialmobility. Our results show little inclusion of maize in these populations? diets,significantly less than those for the same region during pre-Hispanic times. Thedata do not indicate a historic continuity in dietary practices between pre-Hispanicand post Hispanic human population.Chiavazza, H.; Adolfo Gil y Daniela Mansegosa. 2015. Diet and residential mobility in the Argentine Centre West Colony: Stable Isotopes (13c, 15n, 18o) in human bone samples. International Journal of Historical Archaeology. EEUU, Nueva York nº 19 vol 2: 289-308 28 de febrero de 2015. ISBN 1092-7697 DOI: 10.1007 \/ s10761-015-0288-3).","palabras_clave":"Colony|Central Western Argentina|Stable Isotopes|Residential mobility"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17819,"idioma_id":4,"titulo":"Experimental and Visco-Plastic Self-Consistent evaluation of forming limit diagrams for anisotropic sheet metals: An efficient and robust implementation of the M-K model","resumen":"In the present work, an efficient formulation for the prediction of forming-limit diagrams  (FLDs) based on the well-known Marciniak and Kuczynski (MK) theory using a ViscoPlastic  Self-Consistent (VPSC) crystal-plasticity model has been detailed. The present  model extends the previous MK-VPSC implementation (Signorelli et al., Predictions of  forming limit diagrams using a rate-dependent polycrystal self-consistent plasticity model,  International Journal of Plasticity 25 (2009) 1e25) based on the NewtoneRaphson (N-R)  method, which gives no guarantee of a robust iterative procedure. In order to avoid  convergence problems and to reduce the computational cost of the coupled MK-VPSC  scheme, a direct approach (DA) is proposed. The DA eliminates the need of the Jacobian  evaluation associated with the N-R method as well as the iterative procedure tied to other  possible minimization techniques. Moreover, the mechanical states outside and inside the  groove are solved in the sample reference frame, avoiding the need to rotate the crystallographic  orientations and the internal variables to the current band reference frame at  each increment. In this way, only two calls to the material law are required per MK  increment, obtaining a more robust numerical procedure with a significant computational  cost reduction. Interestingly, the requirement of more complex boundary conditions does  not substantially increase the number of internal VPSC iterations to achieve a given  tolerance. Simulation results show that the direct MK-VPSC approach is consistent with  that based on the N-R method. The generalized boundary conditions in the polycrystal  model allowed us to calculate either strain-rate ratio or stress ratio based FLDs. The effect  of using either strain-rate ratio or stress ratio paths on the FLDs has been investigated by  imposing three types of pre-straining on the sheet metals. Formability predictions for a  randomly-textured FCC material and for textured FCC, BCC and HCP polycrystals are presented  and discussed. Finally, by considering dissimilar metals e extra deep-drawing  quality steel (EDDQ), dual-phase steel (DP-780) and pure zinc (Zn20) e we evaluated  the MK-VPSC model´s ability to predict forming-limit strains irrespective of microstructure  and crystallography. The predicted results have been compared with experimental data  and good agreement was found.","palabras_clave":"DUCTILITY|POLYCRYSTALLINE MATERIAL. |VISCOPLASTIC MATERIAL|NUMERICAL ALGORITHMS|FORMING LIMIT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17820,"idioma_id":5,"titulo":"Caracterización de las actitudes de estudiantes universitarios de Matemática hacia los métodos numéricos","resumen":"El objetivo de mejorar el proceso de enseñanza y aprendizaje de los Métodos Numéricos en los estudiantes universitarios de las carreras de Matemática de la Facultad de Ciencias Exactas y Naturales de la Universidad Nacional de Mar del Plata (Argentina), nos llevó a indagar en las posibles causas que podrían influir negativamente en dicho proceso. Encontramos la necesidad de prestar atención a las actitudes, principalmente por considerar que éstas pueden tener una importante influencia sobre el rendimiento académico inmediato. El estudio comprendió una etapa de diseño, prueba piloto, validación del instrumento y análisis de las coherencias de las respuestas mediante la clasificación de conglomerados por variables, una etapa descriptiva y un análisis de las posibles relaciones entre las variables estudiadas. Los resultados muestran que los estudiantes tienen una actitud moderadamente positiva hacia la asignatura, donde el agrado, la valoración y la ansiedad juegan un papel fundamental.","palabras_clave":"Análisis numérico|Actitudes|Validación|Interpretación de datos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17821,"idioma_id":4,"titulo":"Ethanol-induced tolerance  and sex-dependent sensitization in preweanling rats","resumen":"According to genetic studies, the acute stimulating effect of ethanol seems to be associated with an increased predisposition to consume large quantities of ethanol. Ethanol-induced stimulation has been rarely reported in adult rats. However, infant rats, particularly during the second postnatal week of life, are highly sensitive to ethanol-induced behavioral activation. They also consume more ethanol than in later ontogenetic stages. In adult mice repeated ethanol experience usually results in sensitization to the stimulating effect of ethanol, while tolerance is the predominant result in rats. The present study was designed to explore in rats whether repeated exposure to ethanol during infancy modifies subjects´ sensitivity to the stimulating effect of the drug, either increasing or decreasing its magnitude (i.e. sensitization or tolerance, respectively). Furthermore, we also explored the possible context-modulation of these effects. In two experiments, subjects were trained with water or ethanol (2.5g\/kg) between postnatal days (PDs) 8 and 12 (Experiment 1) or between PDs 14 and 18 (Experiment 2), and tested in response to water or ethanol two days later. In these experiments we identified three variables that critically modulate the effect of the repeated ethanol exposure: sex, context and age. Ethanol exclusively and consistently induced locomotor sensitization in males trained outside of the testing context (Experiments 1a and 1b), while tolerance to the stimulating effect of ethanol was observed in males and females trained in the testing context (Experiment 1a). In Experiment 2 tolerance was detected in females trained outside of the testing context. Finally, experience with the testing context during training strongly attenuated the stimulating effect of ethanol in the older subjects (Experiment 2). These results show that the same ethanol treatment can produce opposite effects (tolerance or sensitization) and demonstrate the involvement of Pavlovian conditioning in the development of tolerance. Furthermore, sex was revealed as an important factor to take into consideration in the analysis of chronic experience with ethanol during infancy. We can conclude that specific ontogenetic stages can be used to study the biological determinants underlying both ethanol-induced tolerance and sensitization, and the environmental modulators of these effects. ","palabras_clave":"ETHANOL|INFANT RAT|TOLERANCE|SENSITIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17822,"idioma_id":4,"titulo":"Acetylcholine from Visual Circuits Modulates the Activity of Arousal Neurons in Drosophila","resumen":"Drosophila melanogaster´s large lateral ventral neurons (lLNvs) are part of both the circadian and sleep-arousal neuronal circuits. In the past, electrophysiological analysis revealed that lLNvs fire action potentials (APs) in bursting or tonic modes and that the proportion of neurons firing in those specific patterns varies circadianly. Here, we provide evidence that lLNvs fire in bursts both during the day and at night and that the frequency of bursting is what is modulated in a circadian fashion. Moreover, we show that lLNvs AP firing is not only under cell autonomous control, but is also modulated by the network, and in the process we develop a novel preparation to assess this. We demonstrate that lLNv bursting mode relies on a cholinergic input because application of nicotinic acetylcholine receptor antagonists impairs this firing pattern. Finally, we found that bursting of lLNvs depends on an input from visual circuits that includes the cholinergic L2 monopolar neurons from the lamina. Our work sheds light on the physiological properties of lLNvs and on a neuronal circuit that may provide visual information to these important arousal neurons.","palabras_clave":"DROSOPHILA|ELECTROPHYSIOLOGY|LLNV|ACETYLCHOLINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17823,"idioma_id":4,"titulo":"Contextual learning and context effects during infancy: 30 years of controversial research revisited","resumen":"Over the last 30 years a considerable number of reports have explored learning about context during infancy in both humans and rats. This research was stimulated by two different theoretical frameworks. The first, known as the neuromaturational model, postulates that learning and behavior are context-independent during early ontogeny, a hypothesis based on the idea that contextual learning is dependent on the hippocampal function, and that this brain structure does not reach full maturity until late in infancy. The second theoretical framework views infants not as immature organisms, but rather as perfectly matured ones, given that their behavioral and cognitive capacities allow them to adapt appropriately to the demands of their specific environment in accordance with their maturational level. This model predicts significant ontogenetic variations in learning and memory due to developmental differences in what is perceived and attended to during learning episodes, which can result in ontogenetic differences in contextual learning depending on the specific demands of the task. The present manuscript reviews those studies that have examined potential developmental differences in contextual learning and context effects in rats. The reviewed results show that, during infancy, context can exert a similar influence over learning and memory as that described for the adult rat. Moreover, in some cases, contextual learning and context effects were greater in infants than in adults. In contrast, under other experimental conditions, no evidence of contextual learning or context effects was observed. We analyzed the procedural factors of these studies with the aim of detecting those that favor or impede contextual learning during infancy, and we discussed whether existing empirical evidence supports the claim that the functionality of the hippocampus is a limiting factor for this type of learning during infancy. Finally, conclusions from human research into contextual learning capacities during infancy were also examined. In view of the wealth of evidence showing contextual learning and context effects during infancy, we suggest that future research aimed at exploring the involvement of the hippocampus in this type of learning should be conducted using parameters which allow the expression of contextual learning during each ontogenetic period.","palabras_clave":"APRENDIZAJE|INFANTE|RATA|HIPOCAMPO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17824,"idioma_id":4,"titulo":"Systemic and local toxicity assay of an aqueous extract of Larrea divaricata Cav.: Role of NDGA","resumen":"&nbsp;Larrea divaricata Cav. (Zygophyllaceae) is an autochthonous plant ofSouth America, widely distributed in Argentina. It is used in folk medicine as ananti-inflammatory drug. By other way, presents well documented antitumoral andimmunomodulatory effects. Nordihydroguaiaretic acid (NDGA), an antioxidantcompound, had been previously described in this plant. Nowadays a formulation forhair growth based on an extract of L divaricata is commercialized in Argentina.Taken these into account, the objective of this work was to determine the systemicand local toxicities of the aqueous extract of L divaricata, by giving it under oral andtopical administration. Also, it was proposed to analyze the participation of NDGAin the systemic toxicity of the plant extract. The extract presented low acute toxicity,and the histopathological examination of the tissues did not show any signal oftoxicity at the same time that did not affect biochemical parameters excepteosinophils which were decreased by the treatment. Which is more; the extract didnot exert dermatological or ocular irritation. It is important to note that in relation toits innocuousness and pharmacological properties other phytotherapy formulationscould be prepared in a future.","palabras_clave":"LARREA DIVARICATA|NDGA|AQUEOUS EXTRACT|TOXICITY STUDIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17825,"idioma_id":4,"titulo":"PREVENTIVE ANTI-INFLAMMATORY ACTIVITY OF AN AQUEOUS EXTRACT OF LARREA DIVARICATA CAV. AND DIGESTIVE AND HEMATOLOGICAL TOXICITY","resumen":"Larrea divaricata Cav. commonly known as ?jarilla hembra?is used in folklore medicine as anti-inflammatory. There was no scientificevidence justifying the medicinal use of the aqueous extract for inflammationdiseases. Nowadays, there are two principal types of anti-inflammatorydrugs: Steroidal anti-inflammatory drugs (corticosteroids) and non-steroidalanti-inflammatory drugs (NSAIDs), which exert gastrointestinal ulcerationand bleeding. In this work the preventive anti-inflammatory activity of L.divaricata aqueous extract (AE) in C3H\/He mice was determined bycarrageenan- induced inflammation and ear edema tests, also its toxicity ongastric tissues and on blood cells was studied. The chromatographic profileshowed: nordihydroguaiaretic acid (NDGA) as majority compound. AEexerted anti-inflammatory action without inducing gastric or blood celltoxicities. Also, it could modulate anti-inflammatory and pro-inflammatorycytokines. NDGA was not the compound responsible of the antiinflammatoryaction. This work rescues the potentiality of AE as a gastricand blood cells innocuous anti-inflammatory agent and confirms its ethno-pharmacological uses.","palabras_clave":"LARREA DIVARICATA|ANTI-INFLAMMATORY ACTIVITY|NDGA|AQUEOUS EXTRACT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17826,"idioma_id":4,"titulo":"Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels","resumen":"The aimwas to study the mitochondrial Ca2+ handling of mitochondria isolated fromnormotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) hearts and to establish a possible correlation with systolic blood pressure (SBP). Mitochondrial swelling after Ca2+ addition, Ca2+-retention capacity (CRC) by calcium green method, and membrane potential (&#916;&#936;m) were assessed. SBP was 124 ± 1 (WKY) and 235 ± 6 mm Hg (SHR). CRC, Ca2+ response and &#916;&#936;m were lower in SHR than WKY mitochondria. The Conclusion is: the more depolarized state of SHR thanWKY mitochondria results in an abnormal Ca2+ handling and this event is closely associated with the SBP.","palabras_clave":"WKY AND SHR|MITOCHONDRIA|CALCIUM|BLOOD PRESSURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17827,"idioma_id":4,"titulo":"Multi-structure Power Converter with H-bridge Series Regulator suitable for High-Current High-Precision Pulsed Current Source","resumen":"This work presents a novel multi-structure power converter capable of generating high current pulses with short rise and fall times, and high precision in the flat-top. The proposed topology is based on the use of three conversion structures operated with current, voltage and switching frequency ratings in line with the different requirements of each pulse stage. In order to achieve the required precision, a switched-mode compensation structure in series with the load is used. Though this structure must handle a high load current, it is designed to deviate most of the load current to an auxiliary inductor; thus reducing the semiconductor devices requirements. Moreover, the use of this compensation strategy results in a first-order model of the circuit, which leads to an oscillation-free response during structures interconnection. This feature minimizes the required flat-top time, which in turn decreases the power losses on the load. Experimental results based on a scaled-down laboratory prototype validate the capability of the proposed topology to produce current pulses according to the specifications of highprecision applications.","palabras_clave":"PULSED POWER SUPPLIES|PULSE GENERATOR|SEPTUM|CURRENT CONTROL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17828,"idioma_id":4,"titulo":"Kinetics of tocopherol degradation during the storage of wheat germ oil","resumen":"Tocopherol degradation in wheat germ oil was studied during storage at different temperatures. Two types of wheat germ were used: heat-treated germ (HT) and raw germ (RG). The oil was extracted (Soxhlet, n-hexane) and stored at 25 and 47 8C (82 days) and at -20 and 5 8C (600 days). Tocopherols were determined by HPLC. Total tocopherol, a-tocopherol, and b-tocopherol decreased following first-order kinetics. At 25 and 47 8C, the values of the degradation rate constants for total tocopherol were 5.00_10_3 days_1 (RG), 3.00_10_3 days_1 (HT), and 5.37 _10_2 days_1 (RG), 2.57_10_2 days_1 (HT), respectively, indicating an increase in tocopherol degradation rate with increasing temperature. The reaction rates of total tocopherol were similarly affected at 5 and _20 8C, with lower rate constants (4_10_4 and 2_10_4 days_1, respectively). A tocopherol degraded faster than b-tocopherol, presenting higher rate constants. Low temperatures favour the preservation of tocopherols.","palabras_clave":"Kinetics|degradation|tocopherol|wheat germ oil"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17829,"idioma_id":4,"titulo":"The control volume radial basis function method CV-RBF with richardson extrapolation in geochemical problems","resumen":"The aim of this paper is to present how to implement a control volume approach improved by Hermite radial basis functions (CV-RBF) for geochemical  problems. A multi-step strategy based on Richardson extrapolation is proposed  as an alternative to the conventional dual step sequential non iterative approach  (SNIA) for coupling the transport equations with the chemical model. Additionally, this paper illustrates how to use PHREEQC to add geochemical reaction  capabilities to CV-RBF transport methods. Several problems with different degrees of complexity were solved including cases of cation exchange, dissolution,  dissociation, equilibrium and kinetics at different rates for mineral species. The  results show that the solution and strategies presented here are effective and  in good agreement with other methods presented in the literature for the same  cases.","palabras_clave":"Hermite Radial Basis Functions|Richardson Extrapolation|Chemical Equilibrium|Groundwater Flow"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17830,"idioma_id":4,"titulo":"Post-anthesis N and P dynamics and its impact on grain yield and quality in mycorrhizal barley plants","resumen":"An essential goal for modern agriculture is the simultaneous improvement of productivity efficiency and nutrient use efficiency. One way to achieve this goal in crops is to enhance nitrogen (N) and phosphorus (P) acquisition through  the mycorrhizal association. This study examined the effect of mycorrhization on post-anthesis N and P dynamics and its impact on grain yield and quality in barley. In addition, the efficiency of both N and P utilization and remobilization was evaluated. With those purposes, barley plants inoculated or  not with Rhizophagus intraradices were grown in a soil poor in N and P under greenhouse conditions. Inoculation with R. intraradices in barley enhanced both N and P content in grain and vegetative tissue and reduced phloem amino acid  Export rate. On the other hand, both N and P vegetative tissue content and phloem amino acid and P export rates decreased during grain filling, whereas N and P grain content increased in both treatments according to the senescence process. However, whereas N grain concentration decreased during grain  filling, P grain concentration did not vary, thus suggesting a differential regulation on grain filling. Inoculation with R. intraradices improved the yield and grain quality, thus demonstrating that inoculation with R. intraradices in barley is beneficial, but mycorrhization caused a diminution in nutrient  utilization efficiency. As the phloem remobilization rate of amino acids and P did not decrease during grain filling in R. intraradices-inoculated plants compared to non-inoculated ones, these results suggest that nutrient utilization efficiency is most probably regulated by sink strength rather by a mycorrhizal  effect.","palabras_clave":"CEBADA|MICORRIZAS|NITROGENO|FOSFORO|REMOVILIZACION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17831,"idioma_id":4,"titulo":"Heterosis and Expressivity of Apospory   in Tetraploid Bahiagrass Hybrids","resumen":"Breeding procedures developed for apomictic species are based on the idea of fixing superior hybrids by apomixis. However, scarce information is available about the occurrence of heterosis in apomictic hybrids. The objective was to generate a group of apomixis-segregating tetraploid bahiagrass (Paspalum notatum Flüggé) families, evaluate the occurrence of heterosis for a series of agronomic and morphological traits, determine the level of apospory expressivity among hybrids, and estimate the genetic distance among parents and its relationship to heterosis and apospory expressivity. In total, 11 tetraploid families were generated by crossing sexual and apomitic genotypes. The segregation for mode of reproduction was analyzed using a random amplified polymorphic DNA (RAPD) marker linked to apospory in bahiagrass, and the level of apospory expressivity was determined using embryo sac observations. The genetic distances between parents were determined using inter-simple sequence repeat (ISSR) markers. The ratio between sexual and aposporic hybrids varied from 1:1 to 7:1 among families. Discontinuous variation for apospory expressivity was observed in the hybrids, with either low or high levels being exhibited. Midparent, high-parent, and standard heterosis was observed for all evaluated characteristics. The level of heterosis was dependent on the combination of parents involved and also on the specific trait. There was a low correlation between genetic distances among parents and initial growth and the level of apospory expressivity. The occurrence of heterosis and the segregation and expressivity for apospory were highly dependent on the combination of sexual and apomictic parents.","palabras_clave":"APOMIXIS|POLYPLOIDY|HETEROSIS|PASPALUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17832,"idioma_id":4,"titulo":"Multi-scale analysis of environmental constraints on macrophyte distribution, floristic groups and plant diversity in the Lower Paraná River floodplain","resumen":"he Paraná River floodplain comprises one of the largest wetland systems of South America. In a sector of the Lower Paraná River floodplain (100 km length, 3650 km2), floristic composition and species diversity was characterized in 88 sites surveyed during summers 2010?11 and 2011?12. Hierarchical and fuzzy classifications were used to construct 26 floristic groups and 8 associations of floristic groups, and their indicator species were identified. A number of 124 species was distributed with a zonation pattern conforming marshes, salt marshes, wet prairies, bunchgrasses, grasslands and scrublands. We assessed how vegetation is affected by four nested levels of environmental constraints, representing a gradient from a landscape to a local scale, and including hydrological, geomorphological, topographic and edaphic variables. Species richness differed within categories of broad-scale landscape units (level 1) and within topographic positions (level 3). Also, 30 plant species, six floristic groups and five associations of groups responded to levels 1?3. The first two axes of a constrained Outlying Mean Index ordination accounted for 60% of the marginality of 61 common species as a function of soil features and flood frequency (level 4). Thus, the distribution of seven species showed significant marginality in association to soil electrical conductivity, soil silt percent and soil total nitrogen concentration. Multi-scale environmental constraints determined vegetation zones, and emerging floristic and diversity patterns. The multi-scale approach significantly improves the understanding of floristic patterns and plant biodiversity in the study area, and may be extended to other floodplain wetlands.","palabras_clave":"ENVIRONMENTAL HETEROGENEITY|FRESHWATER WETLANDS|INDICATOR SPECIES|LANSCAPE FILTERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17833,"idioma_id":4,"titulo":"ROLE OF LEPTIN IN FEMALE REPRODUCTION","resumen":"ABSTRACT            Reproductive function is dependent on energy  resources. The role of weight, body composition, fat distribution and the  effect of diet have been largely investigated in experimental female animals as  well as in women. Any alteration in diet and\/or weight may induce abnormalities  in timing of sexual maturation and fertility. However, the cellular mechanisms  involved in the fine coordination of energy balance and reproduction are largely  unknown. The brain and hypothalamic structures receive endocrine and\/or metabolic  signals providing information on the nutritional status and the degree of fat  stores. Adipose tissue acts both as a store of energy and as an active endo­crine  organ, secreting a large number of biologically important molecules termed  adipokines. Adipokines have been shown to be involved in regulation of the  reproductive functions. The first adipokine described was leptin. Extensive  research over the last 10 years has shown that leptin is not only an adipose  tissue-derived messenger of the amount of energy stores to the brain, but also  a crucial hormone\/cytokine for a number of diverse physiological processes,  such as inflammation, angiogenesis, hematopoiesis, immune function, and most  importantly, reproduction. Leptin plays an integral role in the normal  physiology of the reproductive system with complex interactions at all levels  of the HPG axis. In addition, leptin is also produced by placenta, where it  plays an important autocrine function. Observational studies have demonstrated  that states of leptin excess, deficiency, or resistance can be associated with  abnormal reproductive function. This review focuses on the leptin action in  female reproduction.","palabras_clave":"leptin|reproduction|female"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17834,"idioma_id":4,"titulo":"REGULATION OF THE OVARIAN OXIDATIVE STATUS BY LEPTIN DURING THE OVULATORY PROCESS IN RATS","resumen":"Leptin exerts both stimulatory and inhibitory effects  on the ovulatory   process. Here, we investigated whether these opposite effects  involve   changes in the oxidative status in response to different levels of    leptin. To this end, we performed both in  vivo and in vitro assays   using  ovaries of immature rats primed with gonadotropins to induce   ovulation.  Superoxide dismutase (SOD) and catalase activity, lipid   peroxidation, glutathione content, and reactive oxygen species  (ROS)   were studied as oxidative damage-related parameters. The  expression of   Bcl-2, Bax and caspase-3  were measured by Western blot as   apoptosis-related biomarkers. The acute  treatment with leptin, which   inhibits ovulation, decreased SOD activity and  increased active   caspase-3 expression. No differences were found in catalase  activity,   lipid peroxidation or total glutathione. In contrast, the daily    administration of leptin, which induces ovulation, decreased glutathione    content, ROS levels, and Bax and active caspase-3 expression, but   caused no changes  in other parameters. In addition, the daily   administration of leptin induced  follicular growth, measured by the   number of antral follicles in ovarian  sections. Using ovarian explant   cultures, we found increased Bcl-2 expression  and decreased SOD   activity at low and high concentrations of leptin,  respectively. Thus,   leptin can modulate the oxidative status of the ovarian tissue,  during   the ovulatory process, by acting on different targets according to its    circulating levels. At low concentration, leptin seems to have a   protective role  against the oxidative stress, whereas at high   concentrations, this protein  seems to be involved in cell death.","palabras_clave":"Leptin|Ovary|Oxidative Stress"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17835,"idioma_id":4,"titulo":"Thermal stability and antioxidant activity of essential oils from  aromatic plants farmed in Argentina","resumen":"The objective of this  study was to evaluate the antioxidant effect and thermal stability of rosemary,  oregano and laurel essential oils (EO). The major components of the essential  oils were terpineol (E) Beta (55.5%), terpinen-4-ol (15.9%), and thymol (12.9%) in oregano; caryophyllene  (15.8%) in rosemary; and linalool (45.0%), sabinene (31.9%), and methyl eugenol  (14.3%) in laurel. The antioxidant activity of the essential oils was analyzed indirectly  by free-radical scavenging activity (FRSA) and total phenolic content; and  directly by a storage study of sunflower oil measuring the formation of  peroxide and volatile oxidation compounds. The FRSA showed that laurel (61.74%),  oregano (59.97%), and rosemary (48.23%) essential oils showed better percentage  inhibitions than BHT (8.76%). In the storage study of sunflower oil, samples  with 0.10% oregano EO, 0.02% oregano EO, 0.02% laurel EO, and 0.10% rosemary EO  showed better antioxidant properties, exhibiting less peroxide and anisidine  values during storage. Also, 0.02% oregano EO in the storage study showed  reduced formation of volatile compounds like hexanal, 2-heptenal, and  2,4-decadienal. These essential oils have antioxidant activity and constitute  potential agents as antioxidants in food products.","palabras_clave":"essential oils|antioxidants|stability|volatiles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17836,"idioma_id":5,"titulo":"Emergencia de las políticas de vinculación entre el sector científico- académico y el sector productivo en la Argentina (1983-1990)","resumen":"El trabajo aborda el proceso de emergencia de las políticas públicas e institucionales orientadas a la promoción y regulación del vínculo entre el sector científico-académico y los sectores productivos en Argentina durante el período de recuperación democrática que se inicia en 1983 y llega hasta la sanción de la Ley ?de Promoción y Fomento a la Innovación Tecnológica? en el año 1990. El trabajo da cuenta del clima político e intelectual que propició la incorporación de esta cuestión en la agenda pública y del contexto de creación de agencias que tuvieron un rol pionero en la implementación de este tipo de políticas. En este sentido, se examina el papel que tuvo la circulación de conocimientos de expertos internacionales en el diseño de políticas locales y se señalan continuidades y rupturas entre el discurso y las propuestas concebidas durante el período estudiado con concepciones sobre el rol de la producción científica en el proceso productivo generadas en Argentina en décadas previas. Se trata de un trabajo de carácter descriptivo que organiza y sistematiza los textos fundamentales e identifica a los actores relevantes del período a la vez que permite reconocer y presentar núcleos problemáticos para el análisis de la política pública de vinculación de esos años","palabras_clave":"POLÍTICAS DE VINCULACIÓN|SECTOR CIENTÍFICO ACADÉMICO - SECTORES PRODUCTIVOS|DÉCADA DE 1980|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17837,"idioma_id":4,"titulo":"Heart remodeling and ischemia-reperfusion arrhythmias linked to myocardial vitamin D receptors deficiency in obstructive nephropathy are reversed by paricalcitol","resumen":"Cardiovascular disease is often associated with chronic kidney disease and vice versa; myocardial vitamin D receptors are among the probable links between the two disorders. The vitamin D?receptor activator paricalcitol protects from some renal and cardiovascular  complications. However, the structural and electrophysiological effects of myocardial vitamin D?receptor modification and its impact on the response to ischemia-reperfusion are currently unknown. This work attempted to determine whether obstructive nephropathy induced myocardial changes (in rats) linked to vitamin D?receptor deficiency and to  ventricular arrhythmias in Langendorff-perfused hearts. Unilateral ureteral-obstructed and sham-operated rats were treated with either paricalcitol (30ng\/kg\/day, ip) or vehicle for 15 days. In 5 hearts from each group, we found that obstructed rats showed a reduction in  vitamin D receptors and an increase in angiotensin II type-1 receptor expression (mRNA and protein), suffered fibrosis (determined by Masson?s trichrome stain) and myofibril reduction with an increase in mitochondrial size, and had dilated crests (determined by electron  microscopy). These changes were reversed by paricalcitol. In 8 additional hearts per group, we found that obstructed rats showed a higher incidence of ventricular fibrillation during reperfusion (after 10 minutes of regional ischemia) than did those treated with paricalcitol.  The action potential duration was prolonged throughout the experiment in paricalcitol-treated rats. We conclude that the reduction of myocardial vitamin D?receptor expression in obstructed rats might be related to myocardial remodeling associated with an increase in arrhythmogenesis and that paricalcitol protects against these changes by restoring myocardial  vitamin D?receptor levels and prolonging action potentials.","palabras_clave":"ARRHYTHMIAS|PARICALCITOL|REPERFUSION INJURY|VITAMIN D RECEPTOR."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17838,"idioma_id":4,"titulo":"Improvement of Besov regularity for solutions of the fractional Laplacian","resumen":"We prove a mean value formula for weak solutions of $hbox{div}(|y|^{a}hbox{grad}\\u)=0$ in $mathbb{R}^{n+1}={ (x,y): xin mathbb{R}^{n}, yinmathbb{R} }$, $-1&lt;a&lt;1$ and balls centered at points of the form $(x,0)$. We obtain an explicit nonlocal kernel for the mean value formula for solutions of $(-riangle)^{s}f=0$ on a domain $D$ of $mathbb{R}^{n}$. When $D$ is Lipschitz we prove a Besov type regularity improvement for the solutions of&nbsp; $(-riangle)^{s}f=0$.","palabras_clave":"Degenerate Elliptic Equations|Fractional Laplacian|Mean Value Formula|Besov Spaces|Gradient Estimates"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17839,"idioma_id":4,"titulo":"Muc5ac mucin expression during rat skin development","resumen":"Some mucin genes have been detected duringhuman embryonic and fetal organ development;however, little is known about mucinexpression in epidermal development, neitherin humans nor in other species. The presentresearch was developed to explore Muc5acskin expression during pre- and post-natal ratdevelopment. Immunohistochemistry (IHC),Western blotting (WB) and RT-PCR wereemployed. By IHC, Muc5ac protein was foundearly in embryonic epidermis from day 13 ofgestation until seven days after birth when thesurface epidermis became negative and thereaction was restricted to secreting sebumcells. In coincidence with IHC findings, WBanalysis showed a band at approximately200KDa at the same periods of development.Results were also confirmed by RT-PCR.Muc5ac expression in rat embryonic epidermissuggests that Muc5ac may play a protectiverole in embryonic skin previous to birthwhich may be replaced by pile covering. To ourknowledge, this is the first report that confirmedMuc5ac expression during skin development.","palabras_clave":"Muc5ac|skin|rat|development"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17840,"idioma_id":4,"titulo":"Grain size evolution in Cu-based shape memory alloys","resumen":"A study of the grain growth kinetics in two shape memory alloys, CuAlBe and CuZnAl, is reported. Isothermal aging treatments at temperatures between 1023 K and 1123 K were conducted, determining the grain size distribution as a function of time. The results show that the size distribution can be described by a log-normal type relationship, and is time-invariant. It was found that the arithmetic mean grain size almost coincide with the mode, which means that it is a representative parameter of the microstructure along the annealing time. The growth kinetics is strongly dependent on the aging temperature in CuZnAl, while is weakly in CuAlBe. It was verified that the grain size-time power law usually applied is not appropriate to describe the process, and an early departure from the ideal behavior is observed. The modification with a time dependent dragging force gives a reasonable approximation to the grain growth kinetic. The obtained results are compared with the scarce data existing on this type of alloys.","palabras_clave":"Copper-based shape memory alloys|grain growth|grain size distribution|kinetic laws"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17841,"idioma_id":5,"titulo":"Ciudadanía, derechos políticos y conciencia de clase. La cuestión de la naturalización de los extranjeros en los orígenes del socialismo argentino","resumen":"En la Argentina de fines del siglo XIX y comienzos del XX, el crecimiento económico basado en la exportación de materias primas y la llegada de capitales extranjeros se combinaba con un régimen político restrictivo, caracterizado por prácticas fraudulentas y una reducida participación electoral. A pesar de que la legislación garantizaba el sufragio universal para los argentinos varones adultos, la existencia de una gran proporción de inmigrantes colocaba el problema de la participación de los extranjeros como un aspecto crucial. A partir de un extenso análisis de la prensa partidaria, el artículo analiza el modo en que la cuestión de la naturalización de los extranjeros fue abordada por el Partido Socialista argentino desde su misma fundación. La misma aparecía como un paso indispensable para desenvolver una estrategia orientada a la lucha electoral pero al mismo tiempo representaba una demostración de conciencia de los propios trabajadores que debía ser estimulada. A su vez, esta apelación a la naturalización enfrentó desde fechas muy tempranas una serie de escollos, relacionados con las resistencias de numerosos trabajadores a renunciar a su nacionalidad de origen, y luego también con la imposición de diversas trabas burocráticas a partir de la sanción de la Ley de Residencia.","palabras_clave":"SOCIALISMO|CONCIENCIA DE CLASE|NATURALIZACIÓN DE LOS EXTRANJEROS|RÉGIMEN POLÍTICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17842,"idioma_id":4,"titulo":"Prefreezing application of whey protein-based edible coating to maintain quality attributes of strawberries","resumen":"Prefreezing application of whey protein concentrate (WPC)-based edible   coating to maintain quality attributes of strawberries was studied.   Beeswax (BW) was added to the solutions (0%, 20% and 40% with respect to   the solids contained in the mixture WPC\/glycerol). Coated and control   fruits were frozen, stored at -20 °C and thawed. After thawing, weight   loss, firmness, microstructure and colour parameters were measured.   Coating with 20% BW reduced strawberries weight loss after thawing   (55%). Strawberries firmness was maintained equally in all groups   analysed although a slight improvement at the cell microstructure   alterations caused by the freezing process was observed in coated   fruits. Strawberries brightness was similar in all groups. Colour   parameter a* showed a tendency to decrease with the increasing BW concentration, and only b*   of coated fruits was lower than controls. The application of whey   protein coating could be an attractive treatment to maintain quality   attributes of strawberries undergoing the freezing process.","palabras_clave":"Edible coatings|freezing|strawberries|whey proteins"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17843,"idioma_id":4,"titulo":"Generalized mean field description of entanglement in dimerized spin     systems","resumen":"We discuss a generalized self-consistent mean field (MF) treatment, based on  the selection of an arbitrary subset of operators for representing the system  density matrix, and its application to the problem of entanglement evaluation  in composite quantum systems. As a specific example, we examine in detail a  pair MF approach to the ground state (GS) of dimerized spin 1\/2 systems with  anisotropic ferromagnetic-type XY and XYZ couplings in a transverse field,  including chains and arrays with first neighbor and also longer range  couplings. The approach is fully analytic and able to capture the main features  of the GS of these systems, in contrast with the conventional single spin MF.  Its phase diagram differs significantly from that of the latter, exhibiting  (Sz) parity breaking just in a finite field window if the coupling between  pairs is sufficiently weak, together with a fully dimerized phase below this  window and a partially aligned phase above it. It is then shown that through  symmetry restoration, the approach is able to correctly predict not only the  concurrence of a pair, but also its entanglement with the rest of the chain,  which shows a pronounced peak in the parity breaking window. Perturbative  corrections allow to reproduce more subtle observables like the entanglement  between weakly coupled spins and the low lying energy spectrum. All predictions  are tested against exact results for finite systems.","palabras_clave":"Campo medio generalizado|Entrelazamiento|sistemas de espines"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17844,"idioma_id":4,"titulo":"'Workflow Based on Pixel Processing for Automatic Segmentation of Vasculature in Retinographies'","resumen":"We propose a workflow for automatic extraction of the vasculature in color retinal fundus images, mainly optimizes the detection of smaller caliber vessels. This workflow is raised in three stages: preprocessing, processing and post processing. These stages combine various methodologies of lighting correction, enhancement, detection and elimination of spurious vessel structures. The methodologies selected from the state of the art were tested according to this were robust, simple, reliable, fast, clear and affordable. Your selection was based on criteria of sensitivity, specificity, accuracy and positive and negative predictive values. The best performance was obtained by combining lines of work based on matched filter for detecting large and medium vessels caliber, whereas of smaller was obtained with binary morphology through modified Top Hat transform. The evaluation of the proposed workflow was performed using three public databases images and the Gold Standard. The sensitivity achieved for the DRIVE data base exceeds 73%, in STARE 82% and 72% ARIA, when the mask Gold Standard is formed by the segmentation of a single expert observer. These values increase if the mask Gold Standard provides the dispersion between the segmentation of two experts: the sensitivity is increased to 86%, 85% and 83% for each data base, respectively. With the final workflow were achieved precision and specificity values near expert observer, and sensitivity values that exceed those of other publications.","palabras_clave":"automatic segmentation image |fundus vasculature |matched filter|tophat modified |workflow"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17845,"idioma_id":4,"titulo":"Catalytic cracking of bio-oils improved by the formation of mesopores by means of Y zeolite desilication","resumen":"Y zeolite was desilicated by means of alkaline treatments (NaOH 0.05, 0.10 and 0.20 M) during 15 min to produce varying mesoporosity over it. Catalysts were made with a SiO2 matrix and a binder. Pine sawdust bio-oil was produced by pyrolysis and immediately upgraded on a bed of the compound catalysts. The experiments were produced in a fixed bed reactor at 550 ºC using different catalyst to reactants relationships. The desilicated zeolites were more effective than the parent zeolite to deoxygenate bio-oil and produce more hydrocarbons, with higher selectivity to olefins (more than 35 %wt.) and lower selectivity to aromatics (less than 60 %wt.) in gasoline. The selectivity to C4- and gasoline olefins increased if the mesoporosity was higher, and the coke formed was less condensed. These observations were the result of improvements in the diffusion of bulky molecules in bio-oils, such as phenolic ethers, increasing their conversion to hydrocarbons.","palabras_clave":"bio-oils|fuels|desilication|Y zeolite|mesopores"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17846,"idioma_id":4,"titulo":"Analysis of Reports Received by the Pharmacovigilance Unit of National University of San Luis, Argentine","resumen":"Pharmacology of the National University of San Luis was designated as Peripheral Effector of the National Pharmacovigilance System of the National Administration of Drug, Food and Medical Technology in September 2010. The spontaneous reports received of adverse events, medication errors, and lack of efficacy, were analyzed since its conformation until November 2013. The reports were mainly Adverse Events, mostly preventable, possible and mild. Adverse effects were disorders mainly gastrointestinal, general disorders of the organism, of skin and appendages, and psychiatric disorders; while the accused drugs mostly corresponded to the nervous, musculoskeletal and cardiovascular systems. Female gender and patients aged 20-39 years were most affected. Duplication of efforts for greater professional and community formation in Pharmacovigilance, would allow us to increase the quality and quantity of notifications, all for the benefit of the health of the population.","palabras_clave":"Adverse drug reaction|adverse event|Pharmacovigilance|spontaneous reports|peripheral effector"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17847,"idioma_id":5,"titulo":"PLAGUICIDAS DISRUPTORES ENDÓCRINOS, USO DEL NEMATODO  CAENORHABDITIS ELEGANS COMO MODELO BIOLÓGICO","resumen":"Un disruptor endócrino  (DE) es una sustancia exógena capaz de desbalancear el sistema endócrino, afectando funciones vitales como la reproducción, el metabolismo, el crecimiento, la función cardíaca y el balance de minerales. La complejidad del tema obliga a los investigadores, a la industria y a los entes reguladores a estudiar de manera conjunta los efectos potenciales de la exposición a DE. Para esclarecer las problemáticas asociadas, es necesario proponer un modelo experimental alternativo al de mamíferos, que les permitirá adecuarse a las futuras normativas internacionales. Este proyecto plantea el uso del nematodo Caenorhabditis elegans como modelo biológico para el estudio de los mecanismos de acción de los plaguicidas con potencial actividad disruptora endócrina. Este organismo ha resultado un excelente modelo in vivoen disciplinas como biología del desarrollo, genética, ciencias médicas y toxicología. Su ciclo de vida corto, su fácil y bajo costo de mantenimiento y la abundante bibliografía acerca de su fisiología posibilitan el desarrollo de pruebas toxicológicas eficientes y económicas. La información alcanzada en este estudio aportará datos importantes para la estimación de riesgo de plaguicidas con actividad disruptora endócrina y para la innovación de las políticas reguladoras de protección de la salud humana y del medioambiente.","palabras_clave":"Caenorhabditis elegans|Disrupción endócrina|plaguicidas|modelo biológico"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17848,"idioma_id":5,"titulo":"Diatomeas (Bacillariophyceae) en humedales de altura de la provincia de Catamarca (Argentina). III","resumen":"Within the framework of the research on high mountain wetlands conducted since 1998, we have already studied 24 waterbodies in this province. In order to expand our knowledge on diatom flora in these high mountain environments, in this opportunity we analyze another 12 wetlands located between 25 ° 34´05 ´´ - 27 ° 39´23 ´´ S, over 3000 m asl. Diatoms were found in all samples, except in Laguna Azul, with almost white water by the large amount of suspended solids. In relation to salinity, waters were from fresh to hypersaline, with a predominance of sodium and chloride ions. We identify, excluding Fragilariaceae, 42 genera with 123 infrageneric taxa, 29 of which are new records for the province of Catamarca and, 4 for Argentina and we propose a new species (Anomoeoneis punae sp. nov.). The majority of the species belong to Navicula (17), Nitzschia (13), Halamphora (12), Surirella (8), and Anomoeoneis (7). There were not found species common to all samples and only eight appeared in more than 50% of the waterbodies. A high percentage (54%) of rare species, found only in one or two of the samples, was obtained.","palabras_clave":"DIATOMS|WETLANDS|ANDES |CATAMARCA| ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17849,"idioma_id":4,"titulo":"Decoherent time-dependent transport beyond the Landauer-Büttiker formulation: a quantum-drift alternative to quantum jumps","resumen":"We develop and implement a model for decoherence in time-dependent transport. Inspired in a dynamical formulation of the Landauer-B¨uttiker equations, it boils down into a form of wave function that undergoes a smooth stochastic drift of the phase in a local basis, the quantum-drift (QD) model. This drift is nothing else but a local energy fluctuation. Unlike quantum-jumps (QJ) models, no jumps are present in the density as the evolution is unitary. As a first application, we address the transport through a resonant state |0 that undergoes decoherence. Its numerical resolution shows the equivalence with the decoherent steady-state transport in presence of a B¨uttiker?s voltage probe. In order to test the dynamics we consider two many-spin systems, which are cases of experimental interest, where a local energy fluctuation is a natural phenomenon. A two-spin system is reduced to a two-level system (TLS) that oscillates among |0 &#8801; |&#8593;&#8595; and |1 &#8801; |&#8595;&#8593;. We show that the QD model recovers not only the exponential damping of the oscillations in the lowperturbation regime, but also the nontrivial bifurcation of the damping rates at a critical point, i.e., the quantum dynamical phase transition.We also address the spin-wave-like dynamics of local polarization in a spin chain. By averaging over Ns realizations, the QD solution has about half the dispersion respect to the mean dynamics than QJ. By evaluating the Loschmidt echo (LE), we find that the pure states |0 &#8801; |&#8593;&#8595; and |1 &#8801; |&#8595;&#8593; are quite robust against the local decoherence. In contrast, the LE, and hence coherence, decays faster when the system is in a superposition state (|&#8593;&#8595; ± |&#8595;&#8593;)\/&#8730;2, which is consistent with the general trend recently observed in spin systems through NMR. Because of its simple implementation, the method is well suited to assess decoherent transport problems as well as to include decoherence in both one-body and many-body dynamics. DOI: 10.1103\/","palabras_clave":"dynamics|decoherence|wave function|transport"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17850,"idioma_id":4,"titulo":"Physiological  response  of  multiple  contrasting  rice  (Oryza  sativa  L.)  cultivars  to suboptimal temperatures","resumen":"The physiological response of multiple rice cultivars, eighteen initially and eight cultivars later on, to suboptimal temperatures (ST) conditions was investigated in laboratory and outdoor experimental conditions. Treatment with ST decreased growth in different extents according to the cultivar and affected the PSII performance, determined by chlorophyll fluorescence fast-transient test, and stomatal conductance, regardless the experimental condition. Two groups of cultivars could be distinguished on the base of their growth and physiological parameters. The group of cultivars presenting higher growths displayed optimal JIP values, and higher instantaneous water use efficiency (WUEi), due to a lower Gs under ST, unlike cultivars showing lower growth values, which presented worse JIP values and could not adjust their Gs and hence their WUEi. In this work, we detected at least two cultivars with superior tolerance to ST than the cold tolerant referent Koshihikari. These cultivars could be used as parents or tolerance donors in breeding for new crop varieties. On other hand, positive and significant correlations between data obtained from laboratory and outdoor experiments suggest that laboratory measurements of most of the above mentioned parameters would be useful to predict the response of rice cultivars to ST outdoor.","palabras_clave":"INSTANTANEOUS WATER USE EFFICIENCY|JIP TEST|NET PHOTOSYNTHESIS RATE|ORYZA SATIVA|STOMATAL CONDUCTANCE|SUBOPTIMAL TEMPERATURES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17851,"idioma_id":4,"titulo":"On-line policy learning and adaptation for real time personalization of an artificial pancreas","resumen":"The dynamic complexity of the glucose?insulin metabolism in diabetic patients is the main obstacle towards widespread use of an artificial pancreas. The significant level of subject-specific glycemic vari- ability requires continuously adapting the control policy to successfully face daily changes in patient?s metabolism and lifestyle. In this paper, an on-line selective reinforcement learning algorithm that enables real-time adaptation of a control policy based on ongoing interactions with the patient so as to tailor the artificial pancreas is proposed. Adaptation includes two online procedures: on-line sparsifi- cation and parameter updating of the Gaussian process used to approximate the control policy. With the proposed sparsification method, the support data dictionary for on-line learning is modified by checking if in the arriving data stream there exists novel information to be added to the dictionary in order to per- sonalize the policy. Results obtained in silico experiments demonstrate that on-line policy learning is both safe and efficient for maintaining blood glucose variability within the normoglycemic range.","palabras_clave":"Diabetes|Gaussian processes|On-line sparsification|Reinforcement learning"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17852,"idioma_id":4,"titulo":"Effect of trans fatty acids on the nutritional status and lipid metabolism in rats fed linoleic acid enriched and deficient diets","resumen":"This study aimed to investigate the differential effects of trans fatty acids (TFA) on the nutritional  parameters, serum, and tissue triacylglycerol (TAG) levels, as well as the mechanisms involved in their regulation, in male Wistar rats fed linoleic acid-enriched (þLA) or LA-deficient (LA) diets. The TFA  effects on nutritional parameters and TAG metabolism differed depending on the dietary LA status. In the þLA þ TFA diet, compared to the þLA diet, TFA did not alter the serum TAG levels despite the  increased epididymal adipose tissue (EAT) lipoprotein lipase (LPL) activity and the higher hepatic TAG content associated with a lower CPT-Ia activity. Otherwise, in ?LA þ TFA rats versus LA, TFA increased the serum, liver, and adipose tissue TAG levels associated with higher FAS, G6PDH, and ME enzyme activities in both liver and adipose tissue, and a reduced TAG clearance by the adipose tissue LPL enzyme. Although TFA supplementation in both ?LA and þLA-rats tended to decrease the CPT-Ib  activity, the muscle TAG levels were not modified. We conclude that the nutritional and metabolic TFA effects depended mainly on the changesin the FA profile induced by dietary LA and, in a lesser extent, on the specific type of isomer retained in the tissues.","palabras_clave":"ISOMER RETENTION|LIPOPROTEIN LIPASE|LIPOGENIC ENZYMES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17853,"idioma_id":4,"titulo":"Trans fatty acids retention and conversion rates of fatty acids in tissues depend on dietary fat in mice","resumen":"Given that the effects of trans fatty acids (TFA) may be associated with the type of TFA isomerand the proportion of n-3\/n-6\/n-9 fatty acids (FA), this work aimed to investigate the influence ofdifferent oils on the following parameters: content, incorporation, and retention of TFA;conversion of vaccenic acid (VA) to rumenic acid (RA) in different tissues; and hepatic outputof TFA by VLDL. Another objective was to assess relative conversion rates of key FA andthe potential alteration of FA composition induced by TFA in tissues. Male CF1 mice were fed(30-days) diets containing 7% olive, corn or rapeseed oils either supplemented with 0.75% ofTFA or without added TFA. FA composition of liver, epididymal adipose tissue, gastrocnemiusmuscle, brain, and serum was assessed. With the exception of the brain, TFAs were incorporatedinto the analyzed tissues and serum. TFA retention and RA bioconversion from VA depended onthe dietary unsaturated FA proportions. The higher levels of hepatic RA in the liver of mice fedan olive oil.TFA diet could be associated with a raised D9-desaturase index. The FAcomposition of tissues was scarcely modified by the consumption of partially hydrogenatedvegetable oils containing similar proportions of t9-, t10-, and t11-18:1.","palabras_clave":"TRANS FATTY ACIDS|VACCENIC ACID|RUMENIC ACID|D9-DESATURASE|TFA RETENTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17854,"idioma_id":4,"titulo":"Tyrosine Hydroxylase Is Short-Term Regulated by the Ubiquitin-Proteasome System in PC12 Cells and Hypothalamic and Brainstem Neurons from Spontaneously Hypertensive Rats: Possible Implications in Hypertension","resumen":"Aberrations in the ubiquitin-proteasome system (UPS) are implicated in the pathogenesis of various diseases. Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamines biosynthesis, is involved in hypertension development. In this study we investigated whether UPS regulated TH turnover in PC12 cells and hypothalamic and brainstem neurons from spontaneously hypertensive rats (SHR) and whether this system was impaired in hypertension. PC12 cells were exposed to proteasome or lysosome inhibitors and TH protein level evaluated by Western blot. Lactacystin, a proteasome inhibitor, induced an increase of 86+15% in TH levels after 30 min of incubation, then it started to decrease up to 6 h to reach control levels and finally it rose up to 35.2+8.5% after 24 h. Bafilomycin, a lysosome inhibitor, did not alter TH protein levels during short times, but it increased TH by 92+22% above basal after 6 h treatment. Before degradation proteasome substrates are labeled by conjugation with ubiquitin. Efficacy of proteasome inhibition on TH turnover was evidenced by accumulation of ubiquitinylated TH after 30 min. Further, the inhibition of proteasome increased the quantity of TH phosphorylated at Ser40, which is essential for TH activity, by 2.7+0.3 fold above basal. TH protein level was upregulated in neurons from hypothalami and brainstem of SHR when the proteasome was inhibited during 30 min, supporting that neuronal TH is also short-term regulated by the proteasome. Since the increased TH levels reported in hypertension may result from proteasome dysfunction, we evaluate proteasme activity. Proteasome activity was significantly reduced by 67±4% in hypothalamic and brainstem neurons from SHR while its protein levels did not change. Present findings show that TH is regulated by the UPS. The impairment in proteasome activity observed in SHR neurons may be one of the causes of the increased TH protein levels reported in hypertension.","palabras_clave":"tyrosyne hydroxylase|hypertension|neuron"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17855,"idioma_id":4,"titulo":"Ca2+ images obtained in different experimental conditions shed light on the spatial distribution of IP3 receptors that underlie Ca2+ puffs","resumen":"Many intracellular Ca2+ signals involve Ca2+ release from the endoplasmic reticulum through inositol 1,4,5-trisphosphate receptors (IP3Rs). The open probability of IP3Rs depends on cytosolic Ca2+ so that these signals involve Ca2+-induced Ca2+-release (CICR). IP3Rs are organized in clusters. The signals they mediate are observed using single-wavelength dyes and, often, a slow Ca2+ buffer (EGTA) is added to disrupt CICR between clusters and keep the signals spatially restricted. It is assumed that the presence of the dye or of EGTA does not alter the intra-cluster Ca2+ dynamics. In this paper we analyze this issue combining experiments and numerical simulations. We compare the properties of local signals known as puffs observed with different dyes and EGTA concentrations. We determine that although the dye or EGTA does not alter the intra-cluster dynamics, the set of observable events is different depending on the degree of inter-cluster uncoupling of the experiment. An analysis of the observations shows that the events that are missed for insufficient inter-cluster uncoupling are those of fastest amplitude growth rate. This agrees with a spatial organization in which the largest amplitude events correspond to clusters with densely packed active IP3Rs.","palabras_clave":"CALCIUM SIGNALS|PUFFS|DYES|CICR IN CLUSTERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17856,"idioma_id":4,"titulo":"Properties and processing relationship of polyhydroxybutyrate and cellulose biocomposites","resumen":"The aim of this work was the development of totally biodegradable composites for using as packaging in food and agriculture industry. Optimum conditions to obtain bilayer composites from polyhydroxybutyrate (PHB) and cellulose cardboard by solvent casting and compression molding were found.  The composites obtained by casting showed lower moisture absorption than the ones made by compression molding, due to the penetration of PHB solution (hydrophobic) into the fibers of cellulose cardboard (hydrophilic).  However, pressed materials showed better mechanical and permeation properties than the composites obtained by casting, because PHB formed a continuous layer on cellulose cardboard.  Mechanical and barrier properties of the composites were optimized, using the least amount of PHB, due to its high cost. The optimum amount of PHB determined was 10 wt% for composites made by casting and 15 wt% for pressed composites.","palabras_clave":"POLYHYDROXYBUTYRATE|CELLULOSE|BIOCOMPOSITES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17857,"idioma_id":4,"titulo":"Seed conservation by family farmers in the rural-urban fringe area of La Plata region, Argentina: the dynamics of an ancient practice.","resumen":"Two key components of biocultural diversity are agrobiodiversityand knowledge. There is scarce information regarding seed conservationpractices for rural?urban fringe areas, where the GreenRevolution model is part of farmers? rationality. The dynamics ofsuch practice can be observed in La Plata?s Green Belt (Argentina).Conserved seeds and conservation criteria are recorded, in anarea where 71.5% of cultivated (traditional and commercial)agrobiodiversity is conserved. With the introduction of commercialseeds, a process appears in which local wisdom comes into play toadapt to external requirements, which leads to the generation ofnew knowledge. The relation of this practice with the sustainabilityof family agroecosystems is analyzed.","palabras_clave":"agrobiodiversity|in situ conservation| traditional knowledge|sustainability| biocultural diversity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17858,"idioma_id":4,"titulo":"Marine parasites as biological tags in South American Atlantic waters, current status and perspectives","resumen":"Many marine fisheries in South American Atlantic coasts (SAAC) are threatened by overfishing and under serious risk of collapsing. The SAAC comprises a diversity of environments, possesses a complex oceanography and harbours a vast biodiversity that provide an enormous potential for using parasites as biological tags for fish stock delineation, a prerequisite for the implementation of control and management plans. Here, their use in the SAACis reviewed. Main evidence is derived from northern Argentine waters, where fish parasite assemblages are dominated by larval helminth species that share a low specificity, long persistence and trophic transmission, parasitizing almost indiscriminately all available fish species. The advantages and constraints of such a combination of characteristics are analysed and recommendations are given  for future research. Shifting the focus from fish\/parasite populations to  communities allows expanding the concept of biological tags from local to regional scales, providing essential information to delineate ecosystem boundaries for host communities. This new concept arose as a powerful tool to help the implementation of ecosystem-based approaches to fisheries management, the new paradigm for fisheries science. Holistic approaches, including parasites as biological tags for stock delineation will render valuable information to help insure fisheries and marine ecosystems against further depletion and collapse.","palabras_clave":"Biological markers|Fish stock discrimination|fisheries|South West Atlantic"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17859,"idioma_id":5,"titulo":"Importancia de la evaluación del estrés oxidativo en el semen humano","resumen":"Se realizó una revisión bibliográfica con el propósito de estudiar e interpretar el efecto del estrés oxidativo (EO) en el proceso reproductivo. Se utilizaron bases de datos Medline, Science Direct, Endocrine Society y Sociedad Argentina de Andrología. Los seres vivos que utilizan oxígeno para obtener energía son liberadores de sustancias oxígeno reactivas (SRO). Los espermatozoides debido al elevado contenido de ácidos grasos poliinsaturados en su membrana y el escaso citoplasma que limita el nivel de enzimas antioxidantes son susceptibles al daño oxidativo. Niveles de SOR elevados alteran la movilidad y morfología espermática,&nbsp; provocan fragmentación del ADN y disminuyen la concentración espermática. El test de estrés espermático modificado (MOST) estima resistencia de los espermatozoides a la lipoperoxidación. Los niveles aumentados de SOR en hombres con trastornos reproductivos y su correlación con alteraciones seminales y capacidad fecundante sugieren la evaluación del EO en el estudio integral de la pareja que consulta por infertilidad.       ","palabras_clave":"ESTRES OXIDATIVO|ESPERMATOZOIDES|SEMEN|SUSTANCIAS OXIGENO REACTIVO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17860,"idioma_id":4,"titulo":"Novel reactive PEG for amino group conjugation","resumen":"Activated mPEG carbonates are important reagents that have been widely used for the PEGylation of several peptides and proteins by means of stable urethane linkages. In fact, mPEG-N-hydroxysuccinimidyl carbonate and mPEG-p-nitrophenyl carbonate are among the most used reagents in PEGylation technology. However, the synthesis and storage of these reagents are not always easy to resolve. With the aim of surpassing some of the drawbacks associated with the use of activated mPEG-carbonates we have prepared and evaluated a new mPEG- arbonylimidazolium iodide, which can be used for the conjugation of the NH2 group by means of urethane linkages, as an interesting alternative to the known reagents. It is noteworthy that the novel reagent is prepared by a simple two-step procedure under mild experimental conditions. Moreover, we performed a detailed study of the conjugation reaction of interferon-a2b with the carbonylimidazolium derivative, and evaluated the conjugate in in vitro and in vivo studies.","palabras_clave":"PEG|AMINO GROUP CONJUGATION |IFN-&#945;2b"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17861,"idioma_id":4,"titulo":"Arachis hypogaea PGPR isolated from Argentine soil modifies its lipids components in response to temperature and salinity","resumen":"The aim of this work was to clarify the mechanism related to plant growth promoting of a bacterial  strain (L115) isolated from Arachis hypogaea rhizospheres and the effects of high growth temperature  and salinity on phospholipids and fatty acids composition.  L115 was isolated from peanut rhizospheres and identified according to the sequence analysis of the  16S rRNA gene. Phenotypic, metabolic and plant growth promoting rhizobacteria (PGPR) characteristics  of L115 were tested. Inoculation test in plant growth chamber was performed. In addition, L115 was  exposed to a 37 &#9702;C and 300 mM NaCl and phospholipids and fatty acid composition were evaluated.  L115 strain was identified as Ochrobactrum intermedium and was able to increase the peanut shoot  and root length as well as dry weight, indicating a PGPR role by being able to produce indole acetic acid  and siderophores and present ACC deaminase activity. In addition, L115 showed tolerance to both high  growth temperature and 300 mM NaCl. The most striking change was a decreased percentage of 18:1  fatty acid and an increase in 16:0 and 18:0 fatty acids, under high growth temperature or a combination  of increased temperature and salinity. The most important change in phospholipid levels was an increase  in phosphatidylcholine biosynthesis in all growth conditions.  L115 can promote the growth of peanut and can tolerate high growth temperature and salinity modifying  the fatty acid unsaturation degree and increasing phosphatidylcholine levels.  This work is the first to report the importance of the genus Ochrobactrum as PGPR on peanut growth  as well as on the metabolic behaviour against abiotic stresses that occur in soil. This knowledge will be  useful for developing strategies to improve the growth of this bacterium under stress and to enhance its  bioprocess for the production of inoculants.","palabras_clave":"stress|phospholipid|fatty acid|rhizobacteria"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17862,"idioma_id":4,"titulo":"Photodegradation of antibiotic 5-sulfaminouracil in the  presence of vitamin B2: A kinetic study?","resumen":"Objective: This paper studies the kinetics and mechanism of the sensitized photodegradation of 5-sulfaminouracil (SFU). This compound is a synthetic bacteriostatic belonging to the sulfa drugs, usuallydetected in surface water and effluent wastewater.Methods: SFU interacts with electronically excited singlet and triplet states of riboflavin (Rf), 1Rf* and 3Rf*,respectively. The rate constants for these processes were determined in MeOH?H2O by stationaryfluorescence spectroscopy (for kQ(1)) and by laser flash photolysis (for kQ(3)).Results: SFU is photodegraded by visible light irradiation in the presence of the natural sensitizer (Rf). In competitive processes, 3Rf* generates the reactive oxygen species superoxide radical anion (O2?&#8722;) andsinglet molecular oxygen [O2(1&#916;g)], which are involved in SFU photodegradation. In aqueous solutions,where SFU adopts different forms depending on the pH of the medium, the participation of O2(1&#916;g) ispredominant. Therefore, the O2(1&#916;g)-mediated mechanism was evaluated at pHs 7 and 12, employing perinaphthenone as a synthetic photosensitizer.Discussion: The results indicate that SFU is photodegraded through a relatively efficient process in a neutral environment, whereas it is quickly degraded in alkaline media. This is attributed to the ionization of the sulfamino- group, a substituent in the uracil molecule that exerts an activating power on the molecule.Thus, sensitized photodegradation may be an important tool to reduce the environmental impact of SFU.","palabras_clave":"5-SULFAMINOURACIL|RIBOFLAVIN|SINGLET MOLECULAR OXYGEN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17863,"idioma_id":4,"titulo":"Tomato cv. 'Micro-Tom' as a model system to study postharvest chilling tolerance","resumen":"Storage at low temperature is a common practice to extend the market life of many vegetables. Amongother horticultural crops, tomato fruit suffers chilling injury when it is storage under refrigerated con-ditions. Much effort has been made to understand the mechanisms of generation of this physiologicdisturbance, but many aspects need to be clarified yet. Tomato (Solanum lycopersicum) cv. Micro-Tom is a miniature tomato plant with various properties that make it useful as a model system in plant biology.In this work, the potential of tomato cv. Micro-Tom fruit as a model to study chilling injury was inves-tigated. The effect of postharvest chilling was compared on cvs. Micro-Tom and Minitomato, anothervariety with fruit of similar size. Green mature fruits cvs. Micro-Tom and Minitomato were harvestedand stored during 4 weeks at 4 degrees centrigrades. It was observed that tomato cv. Micro-Tom fruit was clearly tolerantto chilling while tomato cv. Minitomato fruit developed severe chilling injury symptoms and avoided ripening. Harvest and chilling altered the length of time between the different ripening stages, the development of red full color and smell. Also, it was shown that harvesting fruits by visual appreciation is arapid and useful method for distinguishing the different ripening stages during tomato cv. Micro-Tom fruit ripening. These results showed that tomato cv. Micro-Tom fruit was able to counteract the strain resulting from the imposed chilling stress. Altogether these data indicate that tomato cv. Micro-Tom fruit is a good model to study the mechanism of postharvest chilling response and tolerance in tomato.","palabras_clave":"TOMATO|CHILLING|POSTHARVEST"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17864,"idioma_id":5,"titulo":"La bioética en la formación del ingeniero","resumen":"La formación de los futuros ingenieros presenta una dicotomía entre el dominio de la racionalidad técnica y la consideración de las cuestiones vinculadas a lo ético y a lo social, cuestiones que siempre están presentes, y que se vuelven fundamentales al desarrollar ingeniería asociada a temáticas médicas. Este hecho es el que, como docentes de la Facultad de Ingeniería de la Universidad de Buenos Aires, nos ha llevado a preguntarnos qué importancia podría tener la bioética en dicha formación. ¿Por qué la bioética? Porque es una disciplina que tiene en cuenta no sólo los derechos del paciente o el bienestar de los seres humanos y de la vida en general, sino también la evaluación de las tecnologías y el control de calidad de los equipos utilizados en medicina [1]. Por ello, consideramos que la bioética debería incluirse en todo programa educativo que contemple los aspectos ético-sociales en la formación de los futuros ingenieros, y que promueva valores tales como la responsabilidad social en el desarrollo y la operación de nuevas tecnologías.","palabras_clave":"Tecnología|Ingeniería|Bioética|Humanismo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17865,"idioma_id":4,"titulo":"Spectrophotometric Method To Quantify Nitrite And Nitrate In Rat Nervous  Tissue","resumen":"Abstract - Nitric oxide (NO) is a gas present in most biological tissues, including nervoustissue.  In nervous system, the many different physiological functions of NO include those of a  neurotransmitter, neuromodulator and inductor of mitochondrial biogenesis. In addition, NO can  be transformed into highly reactive and harmful molecules producing an impairment of DNA,  lipids or proteins, and thus altering their function. This dual action of NO, throughwhich it plays  an important role both in homeostasis and the development of pathological processes, makes this  molecule an interesting target for medical therapies.Because of this, NO tissue concentration  measurement is important for evaluatingvarious physiological and pathophysiological processes.  NO is easily inactivated by oxidation, resulting in the formation of nitrite (NO2  -  ) and nitrate  (NO3  -  ).The classic Griess method is widely used, simple and inexpensive, but is not sensitive  enough to detect the low nitrite concentrations found in nervous tissue. This paper presents a  Griessmethodwith modifications for the determination of low nitrite and nitrate concentrations in  nervous tissue. Our studies showed that the modified Griess method is specific, sensitive, and has  good linearity. Thus our results indicate that the changes introduced in the  Griessmethodareuseful, reliable and adaptable for low nitrate and nitrite concentration measures  in nervous tissue.  Key Words: Nitric Oxide, nitrite, nervous tissue","palabras_clave":"Nitric Oxide|nitrite|nervous tissue"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17866,"idioma_id":4,"titulo":"The recovery process of a population is not always the same: The case of Otaria flavescens","resumen":"Populations of the South American sea lion (Otaria flavescens) were decimated throughout its range along the Atlantic coast.Responses to this decline have been different in different parts of the species? distribution range. Some stocks are stilldecreasing, some remain stable, and some are recovering slowly. In the Southwestern Atlantic, sea lion populations are nowincreasing. However, 50 years after the cessation of hunting these populations have not recovered to the levels they hadbefore exploitation, with the recovery process occurring at the same time as increasing development of human coastalactivities. The aims of this study were to present recent information on abundance and trends in the southern Patagonianpopulation of sea lions and to test the hypothesis of population expansion with a particular recolonization process. Resultsshowed that there was an increase in the number of sea lions in all colonies and a change in the social composition of ninecolonies, but no new breeding colonies were found. The population trajectory of O. flavescens from southern Patagonia wassimilar to that observed in the rest of the South Atlantic populations, but the recovery and recolonization processes are stillin progress. Here we discuss possible explanations of which factors could have delayed the recovery within the SouthwesternAtlantic stocks.","palabras_clave":"Otaria flavescens |South American sea lion|population increase|Patagonia|recolonization process"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17867,"idioma_id":4,"titulo":"Reliable and cost-effective approach for diagnosis of heterozygous F8\/F9 large deletions by quantitative real-time PCR","resumen":"Reliable and cost-effective approach for diagnosis of heterozygous F8\/F9 large deletions by quantitative real-time PCR","palabras_clave":"Quantitative Real Time PCR|Hemophilia|Deletion|F8"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17868,"idioma_id":4,"titulo":"Influence of the spray pyrolysis seeding and growth parameters on the structure and optical properties of ZnO nanorod arrays","resumen":"ZnO nanorods (NRs) were grown on fluorine doped tin oxide (FTO) substrates at low temperatures (90 °C) from Zn2+ precursors in alkaline media previously seeded with ZnO nanoparticles. These were deposited onto the FTO substrate heated at 350 °C by spray pyrolysis of a Zn acetate solution in a water ethanol mixture. The structure of seeds was tuned by the ethanol to water ratio, &#915;, which controls the solvent evaporation rate of drops impinging the substrate. From a detailed characterization using a combination of scanning electron microscopy, X-ray diffraction, UV?visible absorption and cathodoluminescence spectroscopies, the dependence of the morphology and optical properties of the ZnO NRs on the seeding conditions was demonstrated. NRs grown on seeds deposited from solutions with &#915; in the 0.03?0.06 range ? i.e. when the surface excess of ethanol in the water?ethanol mixture has a maximum ? show thinner average diameters and stacking faults due to the presence of zinc blende domains embedded into an overall wurtzite NR. They furthermore exhibit blue-shifted near band edge emission peak and a high deep level emission in cathodoluminescence. All these findings support the use of spray pyrolysis as a simple and reproducible way to control the seeds deposition, influencing the growth, the structure and the optical properties of the final ZnO NRs.","palabras_clave":"Nanostructures |Semiconductors |Thin films Vapour deposition |Optical properties"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17869,"idioma_id":5,"titulo":"El nuevo trabajo industrial: una mirada crítica desde la calidad del empleo","resumen":"En este trabajo se aborda la relación entre las nuevas formas de organización de la producción y la calidad del empleo, a partir de una revisión crítica de las perspectivas más tradicionales. En particular, se discute el impacto de la adopción de las nuevas formas de organización de la producción sobre la calidad del empleo. Para ello se analizan los cambios operados en el proceso de trabajo desde los inicios del capitalismo, especialmente los ocurridos en el último cuarto del siglo XX. Entre las principales conclusiones se destaca que los cambios producidos en los factores que configuran la organización productiva y la gestión del trabajo tienen un impacto discutible sobre la calidad del empleo y el   bienestar de los trabajadores.","palabras_clave":"CALIDAD DEL EMPLEO|CONDICIONES DE TRABAJO|ORGANIZACIÓN DEL TRABAJO|ORGANIZACIÓN DE LA PRODUCCIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17870,"idioma_id":4,"titulo":"Are stocks of immature Loggerhead sea turtles always mixed?","resumen":"Sea turtles perform extensive migratory movements between feeding, developmental and nesting areas. Developmental areas for immature loggerheads turtles (Caretta caretta) are usually composed of individuals from multiple distant rookeries. Thus, impacts on such stocks usually affect multiple colonies, which require international efforts for conservation. This study describes the molecular genetic composition of the more austral foraging and developmental grounds of loggerhead sea turtles in the Atlantic Ocean and infers the possible origin and dispersal patterns of the species. Analyses were performed using shorter (380 bp) and larger (760 bp) sequences of the control region of mitochondrial DNA (mtDNA) from 24 samples of bycatch and 37 samples of stranded loggerhead sea turtles on the coast of the province of Buenos Aires, Argentina. All specimens (N = 61) were adults and sub-adults (mean ± standard deviation curved carapace length CCL = 68.3 ± 13.4 cm; range: 52.0 to 107.0 cm, N = 41 individuals measured). Both shorter and longer mtDNA sequence analysis showed that in the foraging grounds of the Argentinean coast only haplotypes from Brazilian nesting areas (CC-A4 = 98% and CC-A24 = 2% for shorter sequences, and CC A4.2 = 81%, CC A4.1 = 17% and CC A24.1 = 2% for longer sequences) were found. The homogeneous stock located relatively close to the rookery where individuals originated contradicts the paradigm of immature loggerhead sea turtles forming mixed stocks in foraging and developmental areas. The conservation of the stock in coastal areas of Argentina could benefit the nesting population in the nearby Brazilian rookeries, and could be achieved by conservation actions between these two countries, as well as Uruguay in between.","palabras_clave":"Caretta caretta| Conservation strategies| mtDNA control region|Sea turtles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17871,"idioma_id":4,"titulo":"Structural Characterization of Metal Binding to a Cold-adapted Frataxin","resumen":"Life adaptation to low temperatures influences both protein stability and flexibility. Thus, proteins from psychrophilic organisms are excellent models to study relations between these properties. Here we focused on frataxin from Psychromonas ingrahamii (pFXN), an extreme psychrophilic sea ice bacterium which can grow at temperatures as low as -12 °C. This &#945;\/&#946; protein is highly conserved and plays a key role in iron homeostasis as an iron chaperone. In contrast to other frataxin homologs, chemical and temperature unfolding experiments showed that the thermodynamic stability of pFXN is strongly modulated by pH: ranging from 5.5±0.9 (pH 6.0) to 0.9±0.3 (pH 8.0) kcal mol-1. This protein was crystallized and its X-ray structure solved at 1.45 Å. Comparison of B-factor profiles between E. coli and P. ingrahamii frataxin variants (51% of identity) suggests that, although both proteins share the same structural features, their flexibility distribution is different. Molecular dynamics simulations showed that protonation of His44 or His67 in pFXN lowers the mobility of regions encompassing residues 20-30 and the C-terminal end, probably through favorable electrostatic interactions with residues Asp27, Glu42 and Glu99. Since the C-terminal end of the protein is critical for the stabilization of the frataxin fold, the predictions presented may be reporting on the microscopic origin of the global stability decrease produced near neutral pH in the psychrophilic variant. We propose that suboptimal electrostatic interactions may have been an evolutionary strategy for the adaptation of frataxin flexibility and function to cold environments.","palabras_clave":"Frataxin|X-ray crystallography |metal binding sites|structure"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17872,"idioma_id":4,"titulo":"An interval  fuzzy model for magnetic biomonitoring using the specie Tillandsia recurvata  L.","resumen":"Studies of magnetic monitoring for assessing air pollution have been proposed as alternative and complimentary  of chemical methods. Such magnetic studies provide measurements at low cost and relative promptness.  In this work, we present and apply a methodology to build an interval fuzzy model, which calculates  the Tomlinson pollution load index (PLI). The input variables for the model are magnetic parameters  relative to magnetic concentration, grain size and mineralogy. The model aims to two purposes, on one  hand, to calculate the values of PLI only using magnetic variables and, on the other hand, to analyze the  relationship between magnetic and chemical variables. The studied dataset was obtained from measurements  of the biomonitor Tillandsia  recurvata  L.  in a Mexican urban area (Santiago de Querétaro). The best  model was selected from a total of about half a million possible models using a &#64257;tness measure (RIF). The  model yields a satisfactory approximation of the PLI data and it was concluded that PLI increases with  relation to: an increase in concentration of magnetic materials, an additional contribution to the magnetic  signal of paramagnetic materials, and an increase in size of magnetic grains.","palabras_clave":"BIOMONITORING|FUZZY C-MEANS CLUSTERING|MODEL|MAGNETIC PARAMETERS|POLLUTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17873,"idioma_id":5,"titulo":"Hábitos de sueño y trastornos del espectro autista","resumen":"Fundamentos en Humanidades 2015, Nº 27. ISSN 16578961. Resumen Se investigaron los hábitos de sueño en niños y adolescentes con trastornos del espectro autista (TEA, n=12) respecto a un grupo control (GC, n=12). Los hábitos de sueño se evaluaron con la versión para padres del Children`s Sleep Habits Questionnarie (Owens, et al., 2000). Se registró además la temperatura corporal a diferentes horas. El grupo TEA mostró mayor resistencia a la hora de ir a la cama y más despertares nocturnos. Las temperaturas del grupo TEA fueron significativamente más elevadas por la noche que por la mañana en la semana 2 y 4 de registro. Se infiere que las personas con TEA presentarían cierta vulnerabilidad a los problemas de sueño y alteraciones en el ritmo circadiano de la temperatura corporal.","palabras_clave":"TRASTORNOS DEL ESPECTRO AUTISTA|NIÑOS|HÁBITOS DE SUEÑO.  |ADOLESCENTES."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17874,"idioma_id":4,"titulo":"Mutation Detection of E6 and LCR Genes from HPV 16 Associated with Carcinogenesis","resumen":"Human papillomavirus (HPV) is responsible for one of the most frequent sexually transmitted infections.  The first phylogenetic analysis was based on a LCR region fragment. Nowadays, 4 variants are known: African  (Af-1, Af-2), Asian-American (AA) and European (E). However the existence of sub-lineages of the European  variant havs been proposed, specific mutations in the E6 and LCR sequences being possibly related to persistent  viral infections. The aim of this study was a phylogenetic study of HPV16 sequences of endocervical samples  from Córdoba, in order to detect the circulating lineages and analyze the presence of mutations that could be  correlated with malignant disease. The phylogenetic analysis determined that 86% of the samples belonged to  the E variant, 7% to AF-1 and the remaining 7% to AF-2. The most frequent mutation in LCR sequences was  G7521A, in 80% of the analyzed samples; it affects the binding site of a transcription factor that could contribute  to carcinogenesis. In the E6 sequences, the most common mutation was T350G (L83V), detected in 67% of the  samples, associated with increased risk of persistent infection. The high detection rate of the European lineage  correlated with patterns of human migration. This study emphasizes the importance of recognizing circulating  lineages, as well as the detection of mutations associated with high-grade neoplastic lesions that could be correlated  to the development of carcinogenic lesions.","palabras_clave":"HPV|LINEAGES|MUTATION|CERVICAL CANCER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17875,"idioma_id":4,"titulo":"Gold Nucleation Inhibition by Halide Ions: a Basis for a Seed-Mediated Approach","resumen":"In the present work we examine the effect on gold nucleation of halide ions, a typical synthetic variable in the wet-chemical production of gold nanostructures. It was found that the gold homogeneous nucleation by chemical reduction of aqueous gold ions is kinetically quenched by the rise in the halide ions concentration and this effect is stronger as the Au-halide complex stability increases. The nucleation quenching is not exclusively related to a specific reducing agent but appears to be a more general behavior and is affected by the pH of the media. While no nucleation is observed, Au(I) metastable species coexist together with the reducer constituting metastable solutions. It is demonstrated that the nucleation inhibition by halide ions can be employed as a basis for a seed-mediated approach to produce gold nanostructures. The metastable solutions are proved to function as growth baths where Au(I) reduction is triggered on the surface of previously synthesized gold nanoparticles driving their growth in absence of secondary nucleation. It is also shown how, with this approach, the synthesis conditions can be rationally designed in order to obtain gold nanoparticles with the desired properties in a controlled and reproducible fashion","palabras_clave":"Nanoparticles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17876,"idioma_id":4,"titulo":"Withanolides with Antibacterial Activity from Nicandra john-tyleriana","resumen":"ABSTRACT: Eleven new withanolides (1-11), were isolated and characterized from the aerial parts of Nicandra john-tyleriana. Five of these withanolides have an unmodified skeleton (1-5), two are acnistins (6, 7), and four are withajardins (8-11). These new isolates were fully characterized using a combination of spectroscopic techniques (including multidimensional NMR) and mass spectrometry. All compounds were evaluated for their antibacterial activity against Bacillus, Enterococcus, Escherichia, Listeria, Pseudomonas, and Staphylococcus strains.","palabras_clave":"WITHANOLIDES|ANTIBACTERIAL ACTIVITY|NICANDRA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17877,"idioma_id":4,"titulo":"Lithic raw materials and modes of exploitation in quarries and workshops from the center of the Pampean grassland of Argentina","resumen":"Quarry workshops have an important economic, social, cultural, and symbolic role for past hunter-gatherer societies and the northwest Tandilia System would have represented a place of great cultural significance because human groups could have exploited a huge diversity of rocks and minerals. The main objectives in this paper are to analyze different exploitation, production, and use strategies applied on chert and silicified dolomite quarry workshops, and to interpret diverse ways of transport and circulation of these lithic raw materials from procurement areas to other sites in the center of the Pampa grasslands during the Late Holocene. The studies done suggest several modes in raw materials selection in quarries, reduction strategies, tool manufacture, and rock circulation in the landscape. It is proposed that both raw materials could have been transported from workshops to other sites in the form of nodules, different kinds of partially and\/or totally decorticated cores, large flakes, and possibly tools. With the reduction of residential mobility in hunter-gatherer groups during the Late Holocene, the most exploited rocks in the center of the Pampa grasslands were those located nearest the sites, such as chert from the Sierras Bayas hills. Two procurement strategies (embedded and special trips by using logistical mobility) could have been applied on chert and silicified dolomite acquisition. On the other hand, human groups occupying territories far from quarries could have obtained them through social exchange and interaction networks.","palabras_clave":"Argentina|Stone tool technology|Quarry workshops|Chert"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17878,"idioma_id":4,"titulo":"Numerical solution of a 2D lubrication model with Sommerfeld boundary conditions for hip prostheses","resumen":"Prosthetic in-contact surfaces wear is one of the main causes of hip replacements fallure. Lubrication   is essen- tial to reduce the friction and consequently the wear. A two-   dimensional model based on a modified Reynolds equation, was used to   aoalyze the lubricated contact In a hypothetical hip prosthesis. It is   assumed that prosthesis is made of a me- tallic component and a low   rigidity elastic porous material that can absorb or exude Duid. The Duid   pressure and channel Dow shape were simultaneously solved by a double   precision computer code based on the rmite element method, Newton?s   method and parametric continuation. The Information provided by this   model is extremely difficult to obtain by experimental methods. Results   show that a great- er deformation capacity of the elastic material   promotes a thicker lubrication mm and induces a better load distribution   reducing normal stresses; whlle exudation capacity reduces friction and   wear. The sub-ambient pressures predicted and the oscillatory solution,   show the need of more realistic boundary conditions and fmite element   mesh refinement.","palabras_clave":"Finite element|Hip prosthesis|Wear"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17879,"idioma_id":4,"titulo":"Organic - coating of 1 - 2 nm size silicon nanoparticles: effect on the particle properties","resumen":"Photoluminescent silicon nanoparticles of 1-2 nm size were synthesized by a wet chemical procedure and derivatized with propyl amine (NH2SiNP). Surface NH2 groups were used as linkers for further PEG and folic acidattachment (PEG-NHSiNP and Fo-NHSiNP, respectively) in order to provide the particles with efficient targeting to tumors and inflammatory sites.The particles were characterized by TEM, FTIR, XPS, &#61562; potential, DLS, and time-resolved anisotropy.  Thephotophysical properties, photosensitizing capacity, and interaction with proteins were observed to depend on the nature of the attached molecules.WhilePEG attachment to NH2SiNPdid not change the particles photophysical behavior, attached folic acid diminishestheparticlesphotoluminescence. Despite all the particles retained the capacity for 1O2 generation, the efficient 1O2quenching by the attached surface groups might be a drawback when using these particles as photosensitizers of 1O2.In addition, attached folic acid provided the particles with the capacity of superoxide radical anion,O2.-, generation.  The particles are capable of binding to bovine serum albumin (BSA) within quenching distancestotryptophanresidues.NH2SiNPand PEG-NHSiNP ground state complexes with BSA showed binding constantsof (3.1 ± 0.3)&#61620;104 and (1.3 &#61617; 0.4)&#61620;103 M-1, respectively. The lower value observed for PEG-NHSiNPcomplexesindicates that surface PEGylation effectively leads to a reduction in protein absorption, as required for opsonization prevention. An increase in the particles luminescence upon binding to BSA was observed and attributed to the hydrophobic environment provided by the protein. Moreover, NH2SiNP-BSAcomplexesalsoshowedcapacity for resonance energy transfer.","palabras_clave":"Propylamine|Folic Acid|Poly(ethylen glycol)|photoluminesce"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17880,"idioma_id":5,"titulo":"CAMPO DE ONDA EN UN MEDIO ELÁSTICO SEMI-INFINITO LIMITADO POR UNA SUPERFICIE RUGOSA","resumen":"En este trabajo se determina el campo de desplazamiento en un medio elástico semi-infinito, limitado por una superficie aleatoriamente rugosa libre de tensiones. Bajo la consideración que las alturas de la rugosidad son pequeñas en comparación con la longitud de onda, la ecuación del campo de la onda esparcida se encuentra en el marco de la teoría de perturbación. La bondad de los resultados es chequeada con estudios previos que consideran en detalle el caso de rugosidades unidimensionales; teniendo las representaciones obtenidas en este estudio, al caso unidimensional como límite.","palabras_clave":"CAMPO DE ONDA|PROPAGACIÓN|SUPERFICIE RUGOSA |BIDIMENSIONAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17881,"idioma_id":4,"titulo":"Fruit-localized photoreceptors increase phenolic compounds in berry skins of field-grown Vitis vinifera L. cv. Malbec","resumen":"Sunlight exposure has multiple effect on fruits, as it affects the light climate perceived by fruit photoreceptors and fruit tissue temperature. In grapes (Vitis vinifera L.), light exposure can have a strong effect onfruit quality and commercial value; however, the mechanisms of light action are not well understood. The role of fruit-localized photoreceptors in the control of berry quality traits was evaluated under field conditions in a commercial vineyard in Mendoza (Argentina). Characterization of the diurnal dynamics of the fruit light environment in a vertical trellis system indicated that clusters were shaded by leaves during most of the photoperiod. Supplementation of the fruit light environment from 20 days before veraison until technological harvest showed that red (R, 660 nm) and blue (B, 470 nm) light strongly increasedtotal phenolic compound levels at harvest in the berry skins without affecting sugar content, acidity or berry size. Far-red (FR, 730 nm) and green (G, 560 nm) light supplementation had relatively small effects.The stimulation of berry phytochromes and cryptochromes favored accumulation of flavonoid and non-flavonoid compounds, including anthocyanins, flavonols, flavanols, phenolic acids and stilbenes. These results demonstrate that the chemical composition of grape berries is modulated by the light quality received by the clusters under field conditions, and that fruit photoreceptors are not saturated even in areas of high insolation and under management systems that are considered to result in a relatively high exposure of fruits to solar radiation. Therefore, manipulation of the light environment or the light sensitivity of fruits could have significant effects on critical grape quality traits.","palabras_clave":"Fitocromos|Criptocromos|Vitis vinifera|Pigmentación"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17882,"idioma_id":4,"titulo":"Muons in air showers at the Pierre Auger Observatory: Mean number in highly inclined events","resumen":"We present the first hybrid measurement of the average muon number in air showers at ultrahigh energies, initiated by cosmic rays with zenith angles between 62° and 80°. The measurement is based on 174 hybrid events recorded simultaneously with the surface detector array and the fluorescence detector of the Pierre Auger Observatory. The muon number for each shower is derived by scaling a simulated reference profile of the lateral muon density distribution at the ground until it fits the data. A 10^19&#8201;&#8201;eV shower with a zenith angle of 67°, which arrives at the surface detector array at an altitude of 1450 m above sea level, contains on average (2.68±0.04±0.48(sys))×10^7 muons with energies larger than 0.3 GeV. The logarithmic gain dlnN&#956;\/dlnE of muons with increasing energy between 4×1018&#8201;&#8201;eV and 5×1019&#8201;&#8201;eV is measured to be (1.029±0.024±0.030(sys)).","palabras_clave":"COSMIC RAYS|PIERRE AUGER OBSERVATORY|HIGHLY INCLINED EVENTS|MUONS IN AIR SHOWERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17883,"idioma_id":4,"titulo":"Calculus & GeoGebra, an interesting partnership","resumen":"In engineering careers, the study of the Differential and Integral Calculus begins in the first course of Calculus. In order to understand the definitions and theorems involving such contents, students need to handle symbolic and graphical representations.  With GeoGebra, it is possible to create different interactive applications that can be used as teaching tools to illustrate math classes. In this paper, some animations of the fundamental concepts of Calculus are shown, emphasizing the analysis of their geometric interpretations. These tools were designed for the Calculus I course at the Facultad Regional San Nicolás, Universidad Tecnológica Nacional, Argentina.","palabras_clave":"GEOGEBRA|CALCULUS|DEFINITIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17884,"idioma_id":4,"titulo":"Learning styles and visualization in numerical analysis","resumen":"It has been observed that most students of engineering careers prefer learning by watching and doing, in other words, their prevalence style of learning is visual or kinesthetic. On the other side, visualization in computer environments helps students to make their own knowledge construction. In accordance with what was stated above, a toolkit for numerical analysis was developed, so as to assist students in the learning process of the topics covered in different courses of Numerical Analysis at Facultad Regional San Nicolás from the Universidad Tecnológica Nacional of Argentina.","palabras_clave":"NUMERICAL ANALYSIS|VISUALIZATION|LEARNING STYLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17885,"idioma_id":4,"titulo":"Designing tools for numerical integration","resumen":"Visualization, the ability of generating mental images from abstract concepts, is developed in students when technological resources are incorporated in teaching and learning processes, especially in mathematics. In this paper some tools for teaching numerical integration, developed by the authors, are shown. They are included in a set of customized applications designed for the issues studied in courses of Numerical Analysis at the Facultad Regional San Nicolás, Universidad Tecnológica Nacional, Argentina. With a simple interface, so as students can focalize on the concepts taught, these tools combine different semiotic registers in their design.","palabras_clave":"VISUALIZATION|NUMERICAL INTEGRATION|LEARNING OBJECTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17886,"idioma_id":4,"titulo":"Improving the Purification of Hydroxyethyl Starch by means of Supercritical and Near-Critical Fluid Extraction using CO2 and a Mixture of CO2-Ethanol. A combined Experimental and Modeling Study","resumen":"The hydroxyethyl starch purification was performed by means of supercritical and near-criticalfluidextraction within single-phase conditions using CO2 and a mixture of CO2?ethanol. Hydroxyethyl starchwith concentrations of ethylene glycol in the range of 28,000 to 3000 ppm was successfully purified in asingle stage. The intraparticle mass transfer was determined through a hot sphere diffusion model. Thevalues of the effective diffusion coefficients, obtained from the modelfitted to experimental data,indicate that the hindrance for ethylene glycol extraction is due to mass transfer limitations attributed tothe closed pore structure generated during the crystallization of the solid. In the same sense, the stronginteraction between the contaminant and the hydroxyethyl starch at specific points of the surface couldalso be a detrimental factor. We show that, under these working conditions, most of the contaminationcan be removed, providing a simple process which saves the high consumptions of deionized wateremployed in the traditional ultrafiltration.","palabras_clave":"Hydroxyethyl starch|Supercritical carbon dioxide"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17887,"idioma_id":4,"titulo":"Molecular insight into the interaction mechanisms of Amino-2H-imidazole derivatives with BACE1 protease. A QM\/MM and QTAIM study","resumen":"In this study, we described quantitatively the interactions between two new amino-2H-imidazole inhibitors ((R)-1t and (S)-1m) and BACE1 employing a hybrid Quantum Mechanics-Molecular Mechanical (QM\/MM) method together with a Quantum Theory of Atoms In Molecules (QTAIM) analysis.  Our computational calculations revealed that the binding affinity of these compounds is mostly related to the amino-2H-imidazole core, which interact tightly with the aspartate dyad of the active site. The interactions were stronger when the inhibitors presented a bulky substituent with a hydrogen bond acceptor motif pointing toward Trp76, such as the 3,5-dimethyl-4-methoxyphenyl group of compound (S)-1m. Furthermore, the QTAIM analysis revealed that many hydrophobic interactions complement cooperatively the hydrogen bond which is not present when compound (R)-1t is bound to the enzyme.  The combined QM\/MM-QTAIM analysis allows identifying the interactions that account for the activity difference between compounds, even at a nanomolar range.","palabras_clave":"BACE1|QM\/MM calculations|QTAIM study"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17888,"idioma_id":4,"titulo":"Biochemical characterization of the interactions between Doxorubicin and lipidic GM1 micelles with or without Paclitaxel loading","resumen":"Doxorubicin (Dox) is an anthracycline anticancer drug with high water solubility, whose use is limited primarily by significant side effects.  In this study it is shown that Dox interacts with GM1 ganglioside micelles primarily through hydrophobic interactions independent of pH and ionic strength. In addition, Dox can be incorporated even into GM1 micelles already containing highly hydrophobic Paclitaxel (Ptx). However, it was not possible to incorporate Ptx into Dox containing GM1 micelles, suggesting that Dox could be occupying a more external position in the micelles. This result is in agreement with a higher hydrolysis of Dox than Ptx when the micelles were incubated at alkaline pH.  Loading of Dox into GM1 micelles was observed over a broad range of temperature (4 - 55 ºC). Furthermore, Dox-loaded micelles were stable in aqueous solutions exhibiting no aggregation or precipitation for up to 2 months when kept at 4 - 25 ºC and even after freeze-thawing cycles.   Upon exposure to blood components it was observed that Dox containing micelles interact with human serum albumin (HSA). However, the amount of HSA that ended associated to the micelles was inversely related to the amount of Dox suggesting that both could share their binding sites.   In-vitro studies on Hep2 cells showed that the cellular uptake and cytotoxic activity of Dox and Ptx from the micellar complexes were similar to that of the free form of these drugs, even when the micelle was covered with albumin.  These results support the idea of the existence of different nano-domains in a single micelle and that this micellar model could be used as a platform for loading and delivering hydrophobic and hydrophilic active pharmaceutical ingredients.","palabras_clave":"GM1 MICELLES|NANO-DOMAINS|DRUG DELIVERY|HYDROPHOBIC INTERACTIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17889,"idioma_id":4,"titulo":"Synthesis and characterization of ibandronate-loaded silica nanoparticles and collagen nanocomposites","resumen":"      Non-pororus bare silica  nanoparticles, amine modified silica nanoparticles and mesoporous particles,  were evaluated as carriers for sodium ibandronate. The synthesized  nanoparticles were characterized by SEM, TEM, DLS and porosity. Then, their  capacity to incorporate a bisphosphonate drug (sodium ibandronate) and the in vitro release behavior was analyzed  by capillary electrophoresis. Mesoporous and amine-modified particles showed  higher levels of drug incorporation, 44.68 mg g-1 and 28.90 mg g-1,  respectively. The release kinetics from the two types of particles was similar  following a first order kinetics. However, when these particles were included  into collagen hydrogels only mesoporous nanoparticles had a sustained release  for over 10 days.      The biocompatibility of  mesoporous particles towards Saos-2 cells was also evaluated by the MTT assay  observing an increase in cell viability for concentrations lower than 0.6 mg ml-1  of particles and a decrease for concentrations over 1.2 mg ml-1.  Furthermore, when these particles were incubated with mesenchymal cells it was  observed that these particles had the capacity to promote the differentiation  of the cells with a significant increase in the alkaline phosphatase activity.","palabras_clave":"nanoparticles|collagen|ibandronate"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17890,"idioma_id":4,"titulo":"Synchronous fluorescence and multivariate classification analysis as a screening tool for determining Sudan I dye in culinary spices","resumen":"Spices are a globally traded commodity which has been found to be adulterated with forbidden Sudan dyes. This work proposes a screening method for determining the adulteration of paprika varieties (mild, hot and smoked) with Sudan I dye, based on constant-wavelength synchronousfluorescence spectros-copy with multivariate classification. Different wavelength-intervals (Dl) were evaluated. Classification models were built with Partial Least Squares-Discriminant Analysis (PLS-DA) at two Sudan I dye con-centration levels (1 and 5 mg\/L) and they were tested with samples at a lower level (0.5 mg\/L).Classification results were quite satisfactory when a strategy based onfirst-derivative spectra was used for improving classification results. nm was chosen as the optimum wavelength interval giving a 100% of sensitivity and specificity. These results are promising because the risk of assigning adulteratedsamples as safe to be consumed is highly minimized. The proposed method is feasible, rapid and simple taking advantage of Sudan Ifluorescence phenomena in a direct way.","palabras_clave":"CULINARY SPICES ADULTERATION|SUDAN DYES|SYNCHRONOUS FLUORESCENCE|MULTIVARIATE CLASSIFICATION|SCREENING METHODS|FOOD QUALITY CONTROL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17891,"idioma_id":4,"titulo":"Towards broadening thermospray flame furnace atomic absorption spectrometry: In-fluence of organic solvents on the analytical signal of magnesium","resumen":"This study demonstrates the influence of the solvent when thermospray flame furnace atomic absorptionspectrometry (TS-FF-AAS) is employed for the determination of elements of low volatility, taking magnesium(Mg) as leading case. Several organic solvents\/water solutions of different characteristics (density,surface tension, viscosity, etc.) and proportions were employed for the TS-FF-AAS analytical determination.To this end, solutions containing methanol, ethanol and isopropanol in water were assayed.Measurements were performed at different acetylene\/air ratios of the combustion flame and then, thecorresponding response surfaces were obtained. Methanol\/water 75% v\/v as carrier and a fuel rich flamewere found as the most sensitive alternative.In the light of these findings and in order to explain the changes on the analytical signal, the influenceof the solvent characteristics, the sample droplet size and the redox environment was studied. An estimationof the temperature of different zones of the heated flame furnace based on a modified signal ratiopyrometry method was analyzed for comparative purposes. A full discussion is provided throughoutthe paper.Once obtained the best conditions for analysis, Mg was determined in samples of effervescent vitamintablets comparing two different solvents. The tablets were dissolved in methanol\/water 75% v\/v and ethanol\/water 75% v\/v and then, directly introduced in the TS device. The methanol\/water 75% v\/v dissolutionyielded a slightly higher sensitivity when compared to ethanol\/water and thus, the latter was selecteddue to its lower toxicity. The obtained figures of merit are: LOD (3rb): 0.021 mg L1; LOQ (10rb):0.068 mg L1, sensitivity: 0.086 L mg1; RSD%: 3.55, dynamic linear range 0.068?5 mg L1. Comparisonof the results was performed by flame atomic absorption spectrometry (FAAS), showing a goodagreement (95% confidence level, n = 5). Whilst the FAAS approach needed sample mineralization asno complete solubility was attained with both alcohol\/water solvents, TS allowed direct introductionof the sample with an excellent recovery of the analyte after spiking. The whole TS procedure was moreeconomic (lower amount of reagents and wastings, lower time of operation) and faster (60 h1 samplingthroughput) than FAAS.Nonetheless, the main objective of this work is to show that an analytical signal different from zero canbe obtained for Mg via TS by simply choosing the adequate operational variables that allow an optimizationof the mass transfer of the analyte into the atomizer and a favorable dynamics of desolvation\/atomization.This approach could broad TS analytical capabilities to other elements of lower volatility as it is shownhere for the case of Mg.","palabras_clave":"Thermospray|Magnesium|Organic solvents|Droplet size"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17892,"idioma_id":4,"titulo":"Gas-phase oxidation of CH2=C(CH3)CH2Cl initiated by OH radicals and Cl atoms: Kinetics and fate of the alcoxy radical formed","resumen":"Relative kinetics of the reactions of OH radicals and Cl atoms with 3&#8208;chloro&#8208;2&#8208;methyl&#8208;1&#8208;propene has been studied for the first time at 298&#8201;K and 1&#8201;atm by GC&#8208;FID. Rate coefficients are found to be (in cm3&#8201;molecule&#8722;1&#8201;s&#8722;1): k1 (OH&#8201;+&#8201;CH2&#8201;=&#8201;C(CH3)CH2Cl)&#8201;=&#8201;(3.23&#8201;±&#8201;0.35)&#8201;×&#8201;10&#8722;11, k2 (Cl&#8201;+&#8201;CH2&#8201;=&#8201;C(CH3)CH2Cl)&#8201;=&#8201;(2.10&#8201;±&#8201;0.78)&#8201;×&#8201;10&#8722;10 with uncertainties representing&#8201;±&#8201;2&#963;. Product identification under atmospheric conditions was performed by solid phase microextraction\/GC&#8208;MS for OH reaction. Chloropropanone was identified as the main degradation product in accordance with the decomposition of the 1,2&#8208;hydroxy alcoxy radical formed. Additionally, reactivity trends and atmospheric implications are discussed.","palabras_clave":"CLOROALQUENOS|CG-FID-MS|SPME|CINETICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17893,"idioma_id":5,"titulo":"Los talares bonaerenses como hábitat de nidificación del cardenal de cresta roja","resumen":"Esta contribución muestra los principales resultados de los estudios que vienen desarrollando un grupo de investigadores del Museo de La Plata. Estos estudios muestran la relación que existe entre algunos aspectos reproductivos de una especie de ave y las características de los bosques nativos que habita. El ave estudiada es el Cardenal de Cresta Roja (Paroaria coronata) y el hábitat natural que utiliza para reproducirse y alimentarse se conoce con el nombre de ?Talares?. Entre los principales resultados de estos estudios se puede observar que el estado de conservación de estos bosques es relevante para asegurar la reproducción y conservación de esta especie de ave.","palabras_clave":"CARDENAL|TALARES|REPRODUCCIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17894,"idioma_id":5,"titulo":"Algoritmo de Aprendizaje-Q aplicado al control de la Calidad de Potencia en Redes de Media Tensión con Generación Distribuida","resumen":"Agregar Resumen","palabras_clave":"Algoritmo Q|Calidad de Potencia|Generación distribuida|Media Tensión"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17895,"idioma_id":5,"titulo":"Prestaciones alimentarias en la vejez multigeneracional: nuevas consideraciones del Derecho Argentino","resumen":"Publicación indizada en: Catálogo Latindex, DIALNET, Scielo,   Redalyc, SCOPUS, Web of Science, Ulrich´s International Periodicals, EBSCO, JSTOR y otras. --- El Derecho actual vive atravesado por un fenómeno demográfico nunca visto en tiempos precedentes, el envejecimiento multigeneracional. Fenómeno complejo y curioso, cuyos rasgos están determinados por el envejecimiento global creciente y sostenido, tanto como por la presencia de necesidades económicas y culturales particulares, no asumidas suficientemente y que inciden de manera directa en los esquemas tradicionales de responsabilidad jurídica familiar y social frente a la vejez. Este trabajo tiene el propósito de mostrar algunos de estos interrogantes, mediante el análisis específico de la problemática del derecho de alimentos de las personas mayores, en el marco del Derecho de la Vejez Argentino. A tal fin, observaremos por un lado, cómo afecta y cuáles son los desafíos específicos que el envejecimiento multigeneracional instala en el ámbito del Derecho Privado y, por otro, su impacto en la esfera de la responsabilidad jurídica estatal de la Seguridad Social. Una perspectiva compleja y tridimensional del mundo jurídico, nos ha servido de marco teórico referencial para el desarrollo de esta tarea.","palabras_clave":"PRESTACIONES ALIMENTARIAS|ENVEJECIMIENTO MULTIGENERACIONAL|DERECHO DE LA VEJEZ EN ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17896,"idioma_id":4,"titulo":"Ground and whole grain corn: effect on ruminal ph in goats diets.","resumen":"Abstract: The objective of this study was to evaluate the effects of whole and ground corn grain in ruminal pH and total dry matter intake in diets for goats. Eight crossbreed goats (Creole x Nubian) was fitted with a rumen cannula and assigned in a replicated 4 × 4 Latin square experimental design. Two experiments were conducted; in the first test we used whole grain corn and second, ground corn grain. Ruminal pH data was measured for each goat as average pH, area between the curve and a horizontal line at pH 6, and duration less than pH 6. In the first experiment, there were not differences (p> 0.05) on area between the curve and a horizontal line at pH 6, average pH and duration less than pH 6 among diets. A tendency was observed (p= 0.08) to decrease in DMI and the F\/C decreased linearly (p< 0.05) with increasing whole corn in ration. In the second experiment, a significant linear increase was observed (p< 0.05) on area between the curve and a horizontal line at pH 6, with increasing ground corn. A linear decrease (p <0.05) was observed in average ruminal pH and linear increase (p <0.05) in duration less than pH 6. There was no difference in DMI and linear decrease (p <0.05) in F\/C with increasing whole. The milling corn grain, increase the hydrolysis rate of the starch, possibly because to increased bacterial colonization of the horny endosperm surface, lowering ruminal pH.","palabras_clave":"CABRA|MAÍZ|PROCESADO|PH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17897,"idioma_id":5,"titulo":"Delineando una propuesta teórica-metodológica para el análisis de políticas públicas en contextos de antagonismo","resumen":"Este artículo presenta una propuesta de abordaje teórico-metodológico para analizar escenariosen los que las decisiones gubernamentales respecto de políticas y\/o estrategiasde intervención pública entran en tensión con las disposiciones y preferenciasde las poblaciones. Se trata de conjunto de herramientas que permiten darcuenta de las características de las relaciones conflictivas que en un momentodado subyacen a la decisión de una política pública, abriendo de este modo laposibilidad de dar nuevos cauces al análisis sociopolítico de políticaspúblicas. Dentro de este marco, nuestra propuesta se construyó muy cerca losconflictos en torno a la instalación o la continuidad de proyectos deexplotación minera metalífera a gran escala en las Provincias de Córdoba y LaRioja, Argentina, donde surgieron organizaciones de pobladores y vecinos entensión con las decisiones gubernamentales de autorizar, fomentar o ponerlímites a la exploración o explotación por parte de grandes empresas minerasmetalíferas. Lanecesidad de transitar este análisis en un diálogo permanente con nuestro casoempírico nos condujo a recurrir al Análisis de Redes Sociales (ARS) -en su variante cualitativa-, como una importante herramienta paraensayar un ejercicio de operacionalización de las definiciones conceptualesenunciadas. En suma,lo que aquí se ofrece es un análisis sincrónico que reconstruye ese particularmomento de definición e implementación de una política pública en el que actores y sus intereses se construyen, activany disputan, así como también sus posicionesrelativas, sus vínculos y sus estrategias de intervención. Sobreeste ejercicio teórico-metodológico proponemos abrir la discusión,especialmente respecto de su pertinencia, coherencia interna y utilidad para elanálisis empírico.Título:   Intersticios socialesISSN-L:  2007-4964ISSN asociados:  2007-4964Editorial:  El Colegio de Jalisco, A.C.Inicio:  2011","palabras_clave":"Conflicto social|Políticas Públicas|Redes|Metodología"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17898,"idioma_id":5,"titulo":"SOLARIZACIÓN: UNA ALTERNATIVA DE CONTROL DE MALEZAS PARA VIVERISTAS","resumen":"El objetivo de este trabajo fue determinar la efectividad de la solarización como alternativa de control de malezas en sustratos de viveros forestales para la producción de plantines forestales. La experiencia se realizó en la localidad del Zanjón, provincia de Santiago del Estero (Argentina) durante la primavera de 2011. Se utilizaron cuatro sustratos provenientes de diferentes viveros: 1) mantillo de monte sin tamizar y descompuesto; 2) mantillo de desmonte mezclado con suelo; 3) suelo de monte obtenido de la capa superficial; 4) lombricompuesto mezclado con suelo y dos condiciones de solarización: sin solarizar (SS) y solarizado (S). Las variables respuesta observadas fueron: especies, frecuencia y densidad medidas al finalizar solarización y a los 50 días post-solarización. Los resultados se analizaron con modelos lineales mixtos y las diferencias entre medias de tratamientos con la prueba de comparaciones múltiples DGC. En todos los sustratos sin solarizar la densidad de malezas fue mayor a la registrada en los solarizados, con excepción del sustrato 2 en el que no hubo diferencias significativas. Después de la solarización, el número de malezas que emergieron se redujo en forma significativa en todos los sustratos, no existiendo diferencias significativas entre ellos. El efecto postsolarización perduró por varios meses. En Santiago del Estero es factible aplicar la solarización para un control eficiente de las malezas, este es un método más barato que el control manual empleado habitualmente por los productores de la zona. La sencillez del método y su bajo costo, hacen que pueda constituirse en el tratamiento a recomendar a pequeños productores y viveristas.","palabras_clave":"SOLARIZACION|MALEZAS|PLANTINES FORESTALES|VIVEROS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17899,"idioma_id":4,"titulo":"Automorphisms and isomorphisms of quantum generalized Weyl algebras","resumen":"We classify up to isomorphism the quantum generalized Weyl algebras and  determine their automorphism groups in all cases in a uniform way, including  those where the parameter q is a root of unity, thereby completing the results  obtained by [Bavula, V. V.; Jordan, D. A. Isomorphism problems and groups of  automorphisms for generalized Weyl algebras. Trans. Amer. Math. Soc. 353  (2001), no. 2, 769-794] and [Richard, L.; Solotar, A. Isomorphisms between  quantum generalized Weyl algebras. J. Algebra Appl. 5 (2006), no. 3, 271-285]","palabras_clave":"AUTOMORFISMOS|ISOMORFISMOS|ÁLGBRAS DE WEYL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17900,"idioma_id":4,"titulo":"Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment","resumen":"In Chagas disease a first and critical step to address the research and development gap is to establish a consensus on the desirable product profiles in different conditions of use. To foster and inform the development of these much needed tools, PAHO, in collaboration with the Drugs for Neglected Diseases initiative (DNDi), Médecins sans Frontières (MSF), and the Special Programme for Research and Training in Tropical Diseases (TDR), convened a multidisciplinary group of experts in Rio de Janeiro, Brazil (April 2010), to review the evidence and initiate discussions. The meeting established the basis for the development of target product profiles (TPPs) for Chagas Disease at Point-of-Care Diagnosis andAssessment of Response to Treatment, which are reported in this paper.","palabras_clave":"Trypanosoma cruzi|Diagnose|Primary Health Care|Chagas disease"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17901,"idioma_id":4,"titulo":"'A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase'","resumen":"DNA polymerases are enzymes that play a crucial role in DNA metabolism such as replication, repair, transcription, recombination, and chromosome segregation during mitosis. Herein we report the isolation of a new iridoid (6-epi-catalpol, 2) and per-O-acetyl-verbascoside (11) from aerial part of Buddleja cordobensis Grisebach (Buddlejaceae). From compound 2, we have obtained eight compounds by chemical transformation. This group of compounds at a concentration of 500 &#956;M was assayed against Taq DNA polymerase.  Compound 11 (per-O-acetyl-verbascoside) was the most active with an IC50 of 1.21 + 0.18 &#956;M; compounds 9, 2 and 8 were strong inhibitors with IC50 values of 5.57 + 0.70,  21.62 + 0.22 and 78.13 + 0.93 &#956;M, respectively. Compounds 11 and 9 could be a leader structures to development new anticancer chemotherapy medicines and a useful tool to investigate DNA polymerase activity.","palabras_clave":"Natural Products|Taq DNA Polymerase Inhibitors|6-epi-catalpol|Sylil derivatives|Verbascoside"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17902,"idioma_id":4,"titulo":"Calibration method for confocal x-ray microanalysis with polychromatic excitation","resumen":"To apply the fundamental parametersmethod at the confocal setup the knowledge of the sensitivity of the spectrometer is required  which depends on the characteristics of two X-ray lenses: one in the excitation channel and another in the detection channel.  For the particular case of polychromatic excitation, the theory shows that the focalization properties of the excitation lens for all  incident energies affect the X-ray fluorescence intensity. Therefore the traditional calibration method based on the measurement  of standard samples becomes unstable since the number of required fitting parameters is too high. To reduce these parameters a  previous characterization of the excitation lens by a simulation program was employed giving rise to a simplified confocal setup  calibration. The developed calibration method was applied for a confocal spectrometer implemented in the Brazilian Synchrotron  Radiation Source (LNLS)withwhite beam.The experimental parameters of the sensitivitywere obtained fromdepth profile analysis  of several pure thin films.The calibrated confocal setup was used to quantify reference standards in order to validate the calibration  procedure. Our results for elemental concentrations show relative errors less than 15% for the quantitative analysis of a light matrix  reference standard.","palabras_clave":"Confocal|Policapilares"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17903,"idioma_id":4,"titulo":"Green Pavements: Reuse of plastic waste in asphalt mixtures","resumen":"Nowadays, the disposal  of plastic waste is an issue of major concern worldwide because of its  considerable volume and growth. An option to tackle this problem is to recycle  this waste. This alternative reduces the quantity of net  discards, conserves both material and energy and provides a comparatively  simple way to make a substantial reduction in the overall volume of solid  waste. The purpose of this study is  to investigate an environmentally friendly approach about the influence of  recycling different percentages of urban and rural plastic waste by adding them  in a dry process on an asphalt mixture, through a comparative laboratory study.  The resulting mixtures are analyzed considering their volumetric parameters and  the values from diverse laboratory mechanical tests. The performance tests  include, Marshall Stability, Marshall Quotient, indirect tensile strength, fracture  energy, resilient modulus, permanent deformation and creep compliance, which were  carried out on unmodified and modified hot asphalt mixtures. The obtained  results are presented and discussed in this paper showing that the reuse of  recycled plastics in asphalt mixtures is a viable alternative that contributes  to the reduction of plastic wastes as well as the protection of the  environment.","palabras_clave":"GREEN PAVEMENT |SUSTAINABILITY|RECYCLED PLASTICS |ENVIRONMENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17904,"idioma_id":4,"titulo":"STUDY OF SURFACE DAMAGE ON CELL ENVELOPE ASSESED BY AFM AND FLOW CYTOMETRY OF LACTOBACILLUS PLANTARUM EXPOSED TO ETHANOL AND DEHYDRATION","resumen":"Aims: In this work we evaluated freeze-drying damage at surface level on oenological strain Lactobacillus plantarum UNQLp155, as well as its ability to grow in synthetic wine with and without pre-acclimation.   Methods and Results: Damage on cell surface was studied by flow cytometry, Zeta potential and atomic force microscopy and cell survival was analyzed by plate count. Results showed that beside cells acclimated at lower ethanol concentration (6% v\/v) became more susceptible to drying than non-acclimated ones, after rehydration maintain their increased ability to growth in a synthetic wine. Acclimation at a higher ethanol concentration (10% v\/v) produces several damages on the cell surface losing its ability to grow in a synthetic wine.  Conclusions: In this  work we showed by first time that sub-lethal alterations on bacterial surface induced by  a pre-acclimation with a low ethanol concentration (6%) , upon a freeze-drying process, result  in a better bacterial adaptation to the stress conditions of wine-like medium, as well as to the preservation process.  Significance and Impact of Study: Understanding the adaptation of oenological strains to ethanol and these effects on the preservation process has strong impact on winemaking as it allows defining the most appropriate conditions to obtain malolactic starters cultures","palabras_clave":"Wine|Lactobacillus plantarum|freeze-drying|atomic force microscopy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17905,"idioma_id":4,"titulo":"Fe-doped ceria nanopowders synthesized by freeze-drying precursor method for electrocatalytic applications","resumen":"In this work iron doped ceria nanoceramics were successfully synthesized through the freeze-drying method. All the solids were nanocrystalline. The incorporation of iron reduced the crystallite size with the corresponding increment of specific surface area, favoured the sintering of the solids that could be achieved at lower temperatures, increased the reduction percentage achieved in hydrogen flow and increased the amount and strength of basic sites. The lattice parameter showed a continuous decrease with the increment in iron content indicating that iron was incorporated into fluorite ceria structure at concentrations above the solubility limit. Finally, the incorporation of iron improved the conductivity and reduced the activation energy of the process. The higher reducibility, the presence of basic sites and the higher conductivity position iron doped ceria materials as promising anodes for intermediate temperature SOFCs, operated with hydrocarbons.","palabras_clave":"CeO2?Fe2O3 solid solution|Nanoceramics|Freeze-drying|Enhanced reducibility"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17906,"idioma_id":5,"titulo":"Biofumigación con Brassica juncea y Sinapis alba. Acción sobre el crecimiento in vitro de Trichoderma spp. y Azospirillum brasilense","resumen":"El objetivo de este  trabajo fue evaluar el efecto in vitro de la biofumigación con Brassica juncea y Sinapis alba sobre el crecimiento de Trichoderma spp. y Azospirillum  brasilense. Se trituraron plantas de B. juncea y S. alba y se  colocaron por separado en recipientes de plástico en dosis de 5, 15, 25, 35 y 55 g. Sobre el material triturado  se apoyaron cajas de Petri que contenían medio de cultivo inoculado con Trichoderma spp. o A. brasilense. Los  recipientes de plástico se taparon e incubaron en oscuridad durante 7 días, a  25±2ºC (Trichoderma spp.) y a 31±2ºC (A. brasilense). Finalizado ese período, se midió el diámetro de las  colonias de Trichoderma spp. y se  recontó el número de unidades formadoras de colonias de A. brasilense. Se obtuvieron los siguientes resultados: i) no se  observó efecto fungistático de B. juncea  y de S. alba sobre Trichoderma  spp. en ninguna de las dosis; ii) B.  juncea inhibió el crecimiento de las colonias de A. brasilense con dosis de 15 g o superiores, con un aumento de la  inhibición a medida que se incrementó la dosis del biofumigante; iii) S. alba no inhibió el crecimiento de las colonias de A. brasilense en ninguna de las dosis. Estos resultados obtenidos in vitro sugieren que la técnica de  biocontrol con el hongo antagonista Trichoderma  spp. sería compatible con la biofumigación con B. juncea y S. alba. Además, A. brasilense solo sería compatible con  la biofumigación con S. alba y con  dosis bajas de B. juncea.    &nbsp;","palabras_clave":"Biofumigacion|Brassica juncea |Sinapis alba|Trichoderma spp., Azospirillum brasilense"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17907,"idioma_id":4,"titulo":"QSPR study on refractive indices of solvents commonly used in polymer chemistry using flexible molecular descriptors","resumen":"A predictive Quantitative Structure?Property Relationship (QSPR) for the refractive indices of 370 solvents commonly used in the processing and analysis of polymers is presented, using as chemical information descriptors the simplified molecular input line entry system (SMILES). The model employs a flexible molecular descriptor and a conformationindependent approach. Various well-known techniques, such as the use of an external test set of compounds, the cross-validation method, and Y-randomization were used to test and validate the established equations. The predicted values were finally compared with published results from the literature. The simple model proposed correlates the refractive index values with good accuracy, and it is not dependent on 3D-molecular geometries.","palabras_clave":"QSPR theory|polymer|refractive index|graph theory"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17908,"idioma_id":5,"titulo":"La enseñanza monumentalista y utilitarista de las causas de la biodiversidad y de las estrategias para su conservación. Un estudio sobre la transposición didáctica de los manuales de la Educación Secundaria española","resumen":"Este trabajo estudia la presencia y complejidad  en el tratamiento de las causas de la biodiversidad y de las razones para su  conservación que realizan libros de texto de la Educación Secundaria de España.  Para ello, se determinó el ámbito conceptual y axiológico que define  la comunidad de expertos, se examinó el tratamiento propuesto en el currículo  español y se analizaron 50 manuales escolares (27 de la Educación Secundaria  Obligatoria ?ESO- y 30 del Bachillerato). Los resultados mostraron que el  proceso de transposición didáctica vuelve monumentalista  la enseñanza de la biodiversidad, ya que olvida las razones de su existencia, y  se enriquece de connotaciones biologicistas  y utilitaristas sobre los motivos de su conservación, dejando de lado las dimensiones éticas, filosóficas y culturales. Además,  el tratamiento de los manuales escolares de las causas y conservación de la biodiversidad  reveló una marcada distancia de lo señalado en el currículum de España, sobre  todo para el primer curso de la ESO y del bachillerato.","palabras_clave":"DIVERSIDAD BIOLÓGICA|ENSEÑANZA DE LA BIOLOGÍA|CHEVALLARD|LIBROS DE TEXTO|PARQUES NACIONALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17909,"idioma_id":4,"titulo":"Ontogenetic variation in the skulls of Caiman: the case of Caiman latirostris and Caiman yacare (Alligatoridae, Caimaninae)","resumen":"Caiman is one of the five extant genera of alligatorid crocodylians. While several quantitative and qualitative studies exist  on morphological variation in the genus, little is known about ontogenetic effects. Here, we quantify ontogenetic variation  in morphology for Caiman yacare and C. latirostris in a phylogenetic context. A linear regression analysis on twelve skull  measurements of C. yacare and C. latirostris against a measure of size (the first axis of a PCA of all variables) showed high  correlation coefficients (r2=0.89?0.99) and negative allometry. Eight allometric trajectories showed common slopes at different  intercepts, reflecting a common ontogenetic pattern of morphological growth fixed early in ontogeny. The anterior width of the  snout and the posterior width of the skull table are suitable to discriminate between the two species. The relationship between  snout width and snout length is isometric in C. latirostris while it is negatively allometric in C. yacare. These results confirm that  the snout shape is a distinctive feature between species established early in ontogeny. The narrowing and lengthening of the  snout in C. yacare during ontogeny results in adult forms widely represented in other extant taxa within the genus. The broader  and shorter snout in C. latirostris is probably an autapomorphic feature of this species within Caimaninae.","palabras_clave":"ALLOMETRY|CAIMAN LATIROSTRIS|CAIMAN YACARE|CRANIAL VARIATION|ONTOGENY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17910,"idioma_id":4,"titulo":"Development, Characterization and In Vitro Evaluation of Phosphatidylcholine-Sodium Cholate-Based Nanoparticles for siRNA Delivery to MCF-7 Human Breast Cancer Cells","resumen":"Phosphatidylcholine?sodium cholate (SC)-based nanoparticles were designed, characterized, and evaluated as plausible oligonucleotides delivery systems. For this purpose, formulation of the systems was optimized to obtain low cytotoxic vehicles with high siRNA-loading capacity and acceptable transfection ability. Mixtures of soybean phosphatidylcholine  (SPC) and SC were prepared at different molar ratios with 2 %w\/v total concentration; distilled water and two different buffers were used as dispersion medium. Nanoparticles below 150 nm were observed showing spherical shape which turned smaller in diameter as the SC molar proportion increased, accounting for small unilamellar vesicles when low proportions of SC were present in the formulation, but clear mixed micellar solutions at higher SC percentages. Macroscopic characteristics along with physicochemical parameters values supported the presence of these types of structures. SYBR green displacement assays demonstrated an important oligonucleotide binding that increased as bile salt relative content got  higher. Within the same molar ratio, nanoparticles showed the following binding efficiency order: pH 7.4[pH 5.0[distilled water. siRNA-loading capacity assays confirmed the higher siRNA binding by the mixed micelles containing higher SC proportion; moreover, the complexes formed were smaller as the SC:SPC ratio increased. Considering cytotoxicity and  siRNA-loading capacity, 1:2 and 1:4 SPC:SC formulations were selected for further biological assays. Nanoparticles prepared in any of the three media were able to induce dsRNA uptake and efficiently transfect RNA for gene silencing, for the compositions prepared in buffer pH 5.0 being the most versatile.","palabras_clave":"Micelas mixtas|colato de sodio|lecitina|cáncer de mama"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17911,"idioma_id":4,"titulo":"Symmetric bent-shaped liquid crystal dimers showing transitions between optically uniaxial and biaxial smectic phases","resumen":"We report the synthesis of a new homologous series, nBP5, of symmetric bent-shaped liquid crystal dimers bearing 4-oxyphenyl 4´-oxybiphenyl-4-carboxylate mesogenic groups linked by a five-carbon atom spacer. the dimers were characterized by a combination of optical, thermal, temperature-dependent X-ray diffraction and computational techniques. A nematic and two smectic mesophases were detected for each dimer. We observe de ocurrence of transitions from tilted anticlinic smectic organizations to orthogonal mesophases (SmA)which are rarely displayed by bent dimers. Results suggest that the untilted SmA phases colud be of de Vries type.","palabras_clave":"LCD|DEVRIES|SMECTIC|BENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17912,"idioma_id":4,"titulo":"Morphological changes in polycrystalline Fe after compression and release","resumen":"Despite a number of large-scale molecular dynamics simulations of shock compressed iron, the morphological properties of simulated recovered samples are still unexplored. Key questions remain open in this area, including the role of dislocation motion and deformation twinning in shear stress release. In this study, we present simulations of homogeneous uniaxial compression and recovery of large polycrystalline iron samples. Our results reveal significant recovery of the body-centered cubic grains with some deformation twinning driven by shear stress, in agreement with experimental results by Wang et al. [Sci. Rep. 3, 1086 (2013)]. The twin fraction agrees reasonably well with a semi-analytical model which assumes a critical shear stress for twinning. On reloading, twins disappear and the material reaches a very low strength value.","palabras_clave":"Iron|Phase Transformation|Recovery"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17913,"idioma_id":4,"titulo":"The Female Reproductive system of Zearaja chilensis (Guichenot, 1848) (Chondrichthyes, Rajidae). Gametogenesis and Microscopic Validation of Maturity Criteria","resumen":"ABSTRACT  Chondrichthyans are extremely susceptible to overfishing due, among other things, to their reproductive adaptations. Basic knowledge of reproductive parameters is essential, both of ecological andfor economic points of view. Zearaja chilensis is a valuable economic resource. This work analyzes the microanatomy of female reproductive system, as well as the size of the onset of vitellogenesis. The material was fixed in Bouin and processed using routine histological techniques. Both ovaries are equally functional. Folliculogenesis depicts the same pattern of other Chondrichthyans. Follicles with different degrees of maturation coexist in mature animals, with the exception of oogonia, which were only found in immature individuals. Likewise, atretic follicles were recorded in all stages of maturation. The size of yolk input, microscopically recorded, is lower than the detected at naked eye. Oviductal glands and uterus show similarity with those reported in other lecitotrophic cartilaginous fish. This work reports, for the first time, the morfofunctional microanatomy of the species, and puts to the test the accuracy of the commonly employed criteria for the determination of sexual maturity, a critical data when determining management policies.","palabras_clave":"elasmobranch|reproductive system|ovary|Zhearaja chilensis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17914,"idioma_id":4,"titulo":"Morphology and dynamics of testicular gametogenesis in Sympterygia bonapartii (Chondrichthyes, Rajidae)","resumen":"Chondrichthyans constitute a successful group with a long and intricate evolutionary history that makes them highly vulnerable. The smallnose fanskate, Sympterygia bonapartii (MÜLLER & HENLE, 1841) is one of the most disembarked items in commercial harbors in Argentina. In this work, the microscopic architecture of mature male gonads and the dynamics of cysts development are analyzed as an interesting tool for understanding the reproductive biology of this specie. Some biological data related to reproduction are given as well. Two seasons were sampled (fall and spring) and length classes? frequency distribution and maturity stages frequency distribution are given. LT50 for males was estimated as 58.01 cm of total length. Testes are symmetric, peer, lobated, with several germinal zones. Inside the gonads, there are many spermatocysts, which contain reproductive cells at the same developmental stage. On the basis of their cytological and microanatomical features, seven maturative degrees of the spermatogenic series were differentiated. Few Leydig cells were recognized at the interstitial tissue between cysts. The microscopic quantitative analysis performed in this work provides a promising tool that may contribute to a better knowledge of the reproductive cycles of this economically and ecologically important species.","palabras_clave":"Chondrichthyes|reproductive biology|gametogenesis|Sympterygia bonapartii"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17915,"idioma_id":4,"titulo":"Dengue virus entry and trafficking: perspectives as antiviral target for prevention and therapy","resumen":"Dengue virus (DENV) is the etiological agent of the most important human viral infection transmitted by mosquitoes in the world.  In spite of the seriuos health threat that dengue represents, at present there are no vaccine or antiviral agents available and treatment of patients consists of supportive therapy. This review will focus in the process of DENV entry into the host cell as a potential target for antiviral therapy. The recent advances in the knowledge of viral and cellular molecules and mechanisms involved in binding, internalization and trafficking of DENV into the host cell until virion uncoating are commented, together with a revision of the strategies and compounds evaluated for development of antiviral agents targeted to DENV entry.","palabras_clave":"DENGUE VIRUS|ENTRY|ANTIVIRAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17916,"idioma_id":4,"titulo":"A protocol for the in vitro propagation and polyploidization of an interspecific hybrid of Glandularia (G. peruviana x G. scrobiculata","resumen":"The genus Glandularia (Verbenaceae) has more than 50 species and it holds great ornamental poten-tial due to its colorful flowers, long flowering period and low water requirements. Since the floriculturemarket avidly seeks novelties, increasing the diversity within the genus would increase its commercialvalue. Some of the traits that should be improved in these species are their architecture and the sizeand colors of the flowers and leaves. In this sense, obtaining polyploid individuals is an interesting strat-egy to achieve this objective. In this paper a hybrid of Glandularia peruviana × Glandularia scrobiculatawas cultured under in vitro conditions. Different plant growth regulators and their combinations weretested to obtain appropriate multiplication rates. The best results were obtained with the combination of6.6 M thidiazuron\/0.03 M -naphthalenacetic acid, with a multiplication rate of 19 shoots per explant.The plantlets were first rooted and then acclimatized by transferal to an 8.0 cm diameter pot containingGrowing mix®, and maintenance inside a humidity chamber. For poliploydization, the explants wereexposed to colchicine in concentrations of 0.001% and 0.01% for 24 and 48 h. The 40 recovered plantswere characterized according to their DNA content. There were 21 diploids, 14 solid tetraploids, 1 solidoctoploid, 3 chimera tetraploids and 1 chimera octoploid. Phenotypically, the size of the flowers, inflo-rescences, pollen grains and stomata were significantly larger in polyploid individuals. Surprisingly, stemdiameter, leaf size and color intensity of the leaves and flowers were not significantly different betweendiploid and tetraploid individuals. Due to the size of the inflorescences, the tetraploid individuals are apromising starting material for a Glandularia breeding program.","palabras_clave":"Plant biotechnology|Tissue culture|ornamental plant|Breeding"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17917,"idioma_id":4,"titulo":"Ibrutinib impairs the phagocytosis of rituximab-coated leukemic cells from Chronic Lymphocytic Leukemia patients by human macrophages","resumen":"Ibrutinib is an oral irreversible inhibitor of the Bruton Tyrosine Kinase (Btk) which hasshown promising efficacy and excellent tolerability in patients with Chronic LymphocyticLeukemia (CLL) and other B cell malignancies. Ibrutinib inhibits BCR signaling, impairs chemokine-mediated adhesion and migration, and induces moderate levels of apoptosis on CLL cells. It also reduces TCR downstream activation on Th2 cells by targetinganother kinase, the interleukin-2?inducible kinase (Itk). The combination of Ibrutinib withdifferent targeted therapies is now being explored. In a single arm study, the combinationof Ibrutinib and rituximab in patients with high-risk CLL was generally well-tolerated andresulted in an OR rate of 95% and a PFS of 78% at 18-months, the added effect ofrituximab to the Ibrutinb therapy is being tested in a randomized trial testing Ibrutinb versusIbrutinb and rituximab (NCT02007044). Given that macrophages are the most importanteffector cells in the anti-CD20-therapeutic effect in murine models and they probablyplay a key role in human anti-CD20 therapy, we asked whether Ibrutinib could interferewith the capacity of human macrophages to mediate phagocytosis of rituximab-coated CLLcells. Our results showed that Ibrutinib impairs the phagocytosis of rituximab-opsonizedCLL cells by human macrophages.","palabras_clave":"LEUKEMIA|IBRUTINIB|PHAGOCYTOSIS|RITUXIMAB"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17918,"idioma_id":4,"titulo":"Real option valuation of power transmission investments by stochastic simulation","resumen":"Network expansions in power markets usually lead to investment decisions subject to substantial irreversibility and uncertainty. Hence, investors need valuing the flexibility to change decisions as uncertainty unfolds progressively. Real option analysis is an advanced valuation technique that enables planners to take advantage of market opportunities while preventing or mitigating losses if future conditions evolve unfavorably. In the past, many approaches for valuing real options have been developed. However, applying these methods to value transmission projects is often inappropriate as revenue cash flows are path-dependent and affected by a myriad of uncertain variables. In this work, a valuation technique based on stochastic simulation and recursive dynamic programming, called Least-Square Monte Carlo, is applied to properly value the deferral option in a transmission investment. The effect of option´s maturity, the initial outlay and the capital cost upon the value of the postponement option is investigated. Finally, sensitivity analysis determines optimal decision regions to execute, postpone or reject the investment projects.","palabras_clave":"POWER NETWORK|INVESTMENTS|REAL OPTIONS|UNCERTAINTY|FLEXIBILITY|MONTE CARLO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17920,"idioma_id":5,"titulo":"Concepciones de los docentes secundarios sobre la ciencia, su enseñanza y su aprendizaje","resumen":"Se indagan las concepciones sobre la ciencia y su enseñanza en docentes secundarios de ciencia, desde el marco teórico de las teorías implícitas. Los resultados muestran diferencias en las respuestas en función de las dimensiones de las variables y del contexto de indagación","palabras_clave":"CONCEPCIONES|CONOCIMIENTO|APRENDIZAJE|ENSEÑANZA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17921,"idioma_id":4,"titulo":"Double ionization of helium by fast electrons with  theGeneralized  Sturmian Functions method","resumen":"The double ionization of helium by high energy electron impact is studied. The corresponding four-body Schrödinger equation is transformed into a set of driven equations containing successive orders in the projectile?target interaction. The first order driven equation is solved with a generalized Sturmian functions approach. The transition amplitude, extracted from the asymptotic limit of the first order solution, is equivalent to the familiar first Born approximation. Fivefold differential cross sections are calculated for (e, 3e) processes within the high incident energy and small momentum transfer regimes. The results are compared with other numerical methods, and with the only absolute experimental data available. Our cross sections agree in shape and magnitude with those of the convergent close coupling method for the (10+10) eV and (4+4) eV emission energies. To date this had not been achieved by any two different numerical schemes when solving the three?body continuum problem for the fast projectile (e, 3e) process. Though agreement with the experimental data, in particular with respect to the magnitude, is not achieved, our findings partly clarify a long standing puzzle.","palabras_clave":"HELIUM|DOUBLE IONIZATION|FULLY DIFFERENTIAL CROSS SECTION|FIRST BORN APPROXIMATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17922,"idioma_id":4,"titulo":"Discrepancy between theory and experiment in double ionization of helium by fast electrons","resumen":"We compute fully differential cross sections for double ionization of helium by electrons, within the high-impact-energy and low-momentum transfer regimes, using the generalized Sturmian functions approach. Our results are converged relative to the total angular momentum and variable domain size. The method shows very good agreement with convergent close coupling calculations performed by Kheifets et al. [J. Phys. B 32, 5047 (1999)] for all ejection angles for the two electron emission energies considered in the experiments reported in that contribution. Both theoretical methods provide fully differential cross sections that require the same upscaling factors to compare with experimental data and are based on a first-order Born model for the projectile-target interaction. Since that reference was published, there were several theoretical efforts to account for the absolute scale of the experimental results, but agreement in the cross-section magnitude was not achieved even between theories. With the present contribution we conclude that the first-order Born model is now adequately solved, shifting the magnitude controversy towards either the experimental data and\/or the addition of higher degrees of projectile-target interaction to the calculation.","palabras_clave":"DOUBLE IONIZATION|SCATTERING|STURMIANS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17923,"idioma_id":4,"titulo":"Detection and genetic characterization of &#946;-lactamases in Prevotella intermedia and Prevotella nigrescens isolated from oral cavity infections and peritonsillar abscesses.","resumen":"A prospective analysis on beta-lactam resistance mechanisms and beta-lactamase prevalence was conducted on Prevotella intermedia and Prevotella nigrescens recovered from patients with chronic periodontitis and peritonsillar abscesses. Both phenotypic and genotypic methods were performed to characterize the beta-lactamases, their coding genes and their genetic contexts. Overall, beta-lactamase production was observed in 64% (16\/25) P. intermedia and 23.8% (5\/21) P. nigrescens (p &lt; 0.01). Besides higher beta-lactamase production rates were observed in P. intermedia (8\/16) than in P. nigrescens (2\/16) recovered from chronic periodontitis, almost all isolates from peritonsillar abscesses were producers (8\/9 and 3\/3, respectively). cfxA, but not cepA and cblA, was detected in those isolates, which were previously categorized as beta-lactamase producers. CfxA producing isolates displayed higher beta-lactam MICs than non-producers in both species. The most frequent allele was cfxA2, followed by cfxA3 and a new allelic variant named cfxA6. The analysis of the downstream flanking region in the three cfxA variants revealed the association with mobA of Tn4555, suggesting their localization in a mobilizable element. beta-lactam resistance and cfxA carriage prevalence seems to be not only related to the bacterial species but also to the infection site.","palabras_clave":"Prevotella spp.|CfxA|Beta-lactamases"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17924,"idioma_id":4,"titulo":"Microbiological bioassay using Bacillus pumilus to detect tetracycline in milk","resumen":"The tetracyclines (TCs) are widely used in the treatment of several diseases of cattle and their residues may be present in milk. To control these residues it is necessary to have available inexpensive screening methods based on innocuous bacteria. The purpose of this study was to design a bioassay of microbiological inhibition in microtiter plates with spores of Bacillus pumilus to detect TCs at concentrations the Maximum Residue Limits (MRLs). Several complementary experiments were performed to design the bioassay. In the first study, we determined the concentration of spores that produce a change in the bioassay?s relative absorbance in a short time period. Subsequently, we assessed the concentration of chloramphenicol required to decrease the detection limit (DL) of TCs at MRLs levels. Thereafter, specificity, DL and cross-specificity of the bioassay were estimated. The most appropriate microbiological inhibition assay had a B. pumilus concentration of 1.6 109 spores\/ml, fortified with 2500 µg\/l of chloramphenicol (CAP) in Mueller Hinton culture medium using brilliant black and toluidine blue as redox indicator. This bioassay detected 117 µg\/l of chlortetracycline, 142 µg\/l of oxytetracycline and 105 µg\/l of tetracycline by means of a change in the indicator?s colour in a period of 5 hours. The method showed good specificity (97.9%) which decreased slightly (93.3%) in milk samples with high somatic cell counts (> 250,000 cells\/ml). Furthermore, other antimicrobials studied (except neomycin) must be present in milk at high concentrations (from >5 to >100 MRLs) to produce positive results in this assay, indicating a low cross specificity.","palabras_clave":"Tetracycline|microbial inhibition method|milk|Bacillus pumilus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17925,"idioma_id":4,"titulo":"Changes in Average Annual Precipitation in Argentina?s Pampa Region and Their Possible Causes","resumen":"Changes in annual rainfall in five sub-regions of the Argentine Pampa Region (Rolling, Central, Mesopotamian, Flooding and Southern) were examined for the period 1941 to 2010 using data from representative locations in each sub-region. Dubious series were adjusted by means of a homogeneity test and changes in mean value were evaluated using a hydrometeorological time series segmentation method. In addition, an association was sought between shifts in mean annual rainfall and changes in large-scale atmospheric pressure systems, as measured by the Atlantic Multidecadal Oscillation (AMO), the Pacific Decadal Oscillation (PDO) and the Southern Oscillation Index (SOI). The results indicate that the Western Pampas (Central and Southern) are more vulnerable to abrupt changes in average annual rainfall than the Eastern Pampas (Mesopotamian, Rolling and Flooding). Their vulnerability is further increased by their having the lowest average rainfall. The AMO showed significant negative correlations with all sub-regions, while the PDO and SOI showed significant positive and negative correlations respectively with the Central, Flooding and Southern Pampa. The fact that the PDO and AMO are going through the phases of their cycles that tend to reduce rainfall in much of the Pampas helps explain the lower rainfall recorded in the Western Pampas sub-regions in recent years. This has had a significant impact on agriculture and the environment.","palabras_clave":"AGRO-CLIMATOLOGY|VARIABILITY|SEGMENTATION OF HYDROLOGICAL TIME SERIES|TELECONNECTIONS|CLIMATE INDICES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17926,"idioma_id":4,"titulo":"Trypanosoma cruzi infectivity assessment in 'in vitro' culture systems by automated cell counting","resumen":"Chagas disease is an endemic, neglected tropical disease in Latin America that is caused by  the protozoan parasite Trypanosoma cruzi. In vitro models constitute the first experimental approach  to study the physiopathology of the disease and to assay potential new trypanocidal agents. Here, we  report and describe clearly the use of commercial software (MATLAB®) to quantify T. cruzi  amastigotes and infected mammalian cells (BeWo) and compared this analysis with the manual one.  There was no statistically significant difference between the manual and the automatic quantification  of the parasite; the two methods showed a correlation analysis r2 value of 0.9159. The most significant  advantage of the automatic quantification was the efficiency of the analysis The drawback of this  automated cell counting method was that some parasites were assigned to the wrong BeWo cell,  however this data did not exceed 5% when adequate experimental conditions were chosen. We  conclude that this quantification method constitute an excellent tool for evaluating the parasite load in  cells and therefore constitutes an easy and reliable ways to study parasite infectivity.","palabras_clave":"Trypanosoma cruzi|Chagas|Placenta|Cell counting"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17927,"idioma_id":5,"titulo":"La mortalidad infantil en Santa Fe, Argentina (2007-2011). Un aporte al monitoreo de los derechos de los niños.","resumen":"La mortalidad infantil en Santa Fe tuvo un comportamiento similar en Argentina, acompañando el descenso que se presentó para el país, aunque siempre con valores inferiores al indicador nacional. Pese a ello mereció particular preocupación la elevada proporción de defunciones cuyas causas se consideran reducibles con valores históricos superiores al 50%.  El establecimiento de las metas internacionales conocidas como Objetivos de Desarrollo del Milenio, que bregó por la protección de los derechos de los niños, contó con la ratificación nacional al tiempo que la provincia se comprometió con éstos fijándolos como política socio-sanitaria estratégica. El estudio construyó el perfil de la mortalidad infantil de la provincia de Santa Fe durante el quinquenio 2007-2011. Se realizó un estudio epidemiológico descriptivo y transversal. La población incluyó las defunciones en menores de un año del período estudiado. Se analizó su distribución según la edad al morir, peso al nacer y lugar de ocurrencia, causas de muerte y criterios de reducibilidad. Ocurrieron 2.904 muertes de niños, obteniendo una tasa del 10,9?, que mantuvo el comportamiento descendente previo. Las muertes neonatales duplicaron la mortalidad posneonatal y se concentraron en la primera semana de vida. Las causas más frecuentes estuvieron asociadas a los problemas perinatales. El mayor riesgo de morir fue para los niños de menos de 1.000 gramos o inmadurez extrema. El 60% de los eventos podría haberse evitado. La persistencia de muertes consideradas reducibles debería estimular para incentivar estrategias de intervenciones sociales y sanitarias más equitativas y de protección de la infancia.","palabras_clave":"MORTALIDAD INFANTIL|CONDICIONES DE SALUD|CAUSAS DE MUERTE|DERECHOS DE LA NIÑEZ"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17928,"idioma_id":4,"titulo":"Social preferences are not enough: Accounting for  anomalous behavior in a complex mixed-motive game","resumen":"In some economic games, participants systematically display behavior that departs from the model of payoff maximization, and this is usually attributed to social preferences. In this paper we focus on a new interactive context, a mixed-motive game called ?Alternative Traveler?s Dilemma? (ATD). In this context, most participants choose strictly dominated strategies. Preliminary studies suggest the reason for such a tendency is that participants have social preferences, usually competitive in nature. The question is whether some cognitive factor should also be included in models that accounts for the tendency at stake. More specifically, we investigate whether participants neglect payoff maximization, that is, whether they fail to notice that, by pursuing some competitive goal, they are not maximizing their payoffs. We report the results of an experiment that supports this hypothesis. We conclude that in order to explain anomalous behavior in the ATD and similar games, we need to study the cognitive factors that bound participants? strategies and understanding of the game.","palabras_clave":"Mixed-Motives Game|Anomalous Behavior|Social Preferences|Payoff Maximization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17929,"idioma_id":4,"titulo":"Ensifer (Sinorhizobium) fredii Interacted more  efficiently than Bradyrhizobium japonicum with  Soybean","resumen":"Aims:The purpose of this work was to compare the efficiency of Bradyrhizobium japonicum and Ensifer fredii to infect and develop nodules on soybean. Furthermore we also evaluated the competitive ability of both species and how this was altered by the plant genotype and the soil pH.   Study design:  The design of the experiments was completely at random and the number of replicates was different on each of the different experiments tested.   Place and Duration of Study: Department of Medicine (Medical Unit IV) and Department of Radiology, Services Institute of Medical Sciences (SIMS), Services Hospital Lahore, between June 2009 and July 2010. The whole work lasted about a year and a half.  Methodology: Roots of inoculated soybean plants were fixed and the number of infection initiation sites was evaluated by means of microscopic observation. The number of nodules developed by inoculated plants was also evaluated.   Results: Bacteria were equally effective at developing infection initiation sites on soybean however, E. fredii induced more nodules than B. japonicum, probably due to the fact that E. fredii is more efficient than B. japonicum at nodulating soybean. However, Bradyrhizobium was more competitive than E. fredii which was unrelated to the soybean genotype but altered by the soil pH. Under the conditions described E. fredii was less competitive than B. japonicum probably due to the high cultivar-rhizobia specificity.   Conclusion: Therefore, we concluded that E. fredii was as efficient as B. japonicum at nodulating soybeans. However Bradyrhizobium was a better competitor though this is affected by the plant genotype and the soil pH. The selection and use of fast growing rhizobia in inoculant production seems to depend on broadening the genetic base of soybean or in selecting cultivars with specificity for fast growing rhizobia.","palabras_clave":"Bradyrhizobium|Ensifer fredii|Nodulation|Competition"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17930,"idioma_id":4,"titulo":"Hierarchical bioglass scaffolds: introducing the 'milky way' for templated bioceramics","resumen":"Free standing hierarchical bioglass scaffolds were prepared by the ISISA (ice-segregation-induced selfassembly) method. Commercial low-cost precursors such as Ludoxs HS-40 and cow milk were  employed as the source of SiO2 and biominerals (Ca(II), P(V), Na(I) and K(I)), respectively. Then, in a single macroscopic piece, three levels of porosity coexist due to the simultaneous templating effect of ice (macropores), milk (50?200 nm mesopores) and the voids left between preformed Ludoxs nano building blocks (2?5 nm mesopores). These low cost and green biological nanotemplates, coupled with the ISISA texturing method, allows the preparation of free standing bioglass monoliths, with hierarchical porosity.  The effect of the main preparative variables on the final texture is explored; in vitro biomineralization revealed a well-distributed hydroxyapatite-like nanoparticulated layer within 24 h of exposure to a simulated body fluid.","palabras_clave":"bioglass|scaffold|hierarchical|green chemistry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17931,"idioma_id":4,"titulo":"Factors triggering cyanobacteria dominance and succession during blooms in a hypereutrophic drinking water supply reservoir","resumen":"As freshwater bodies become enriched in nutrients, there is a shift in the phytoplankton community toward dominance by cyanobacteria. Cyanobacterial blooms are a significant problem in water supply reservoirs worldwide because some species can release toxic compounds and are also associated with the production of bad odor and taste. The aims of this paper were to elucidate the mechanism inducing the development of cyanobacterial blooms and to understand the species succession during the bloom, as well as the influence of abiotic factors on the species composition. Total phosphorus level and parameters related to seasonality, i.e., temperature and solar radiation, were the factors triggering the development of the blooms. Blooms were dominated by Microcystis natans and Anabaena circinalis. Phosphorus was an important limiting factor for Anabaena development but never limited Microcystis growth. Water temperature was optimum until end of February for Anabaena, whereas Microcystis growth was slightly limited since water temperature never reached the optimal. Solar radiation was more limiting than temperature, and the decrease in light had a strong role in the bloom decline. Four species of cyanobacteria recorded in Paso de las Piedras reservoir are potentially toxic: Snowella fennica, Microcystis aeruginosa, Planktothrix agardhii, and A. circinalis, being the last one as the most abundant species during the blooms. Considering the Alert Level Framework for cyanobacteria, alert level 2 was exceeded only during blooms while alert level 1 was exceeded during almost all the year.","palabras_clave":"PASO DE LAS PIEDRAS RESERVOIR|PHYTOPLANKTON |MATHEMATICAL MODEL |MICROCYSTIS|ANABAENA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17932,"idioma_id":5,"titulo":"Prácticas y tendencias en las técnicas de reclutamiento y selección de personal en las MiPyMEs de alojamiento turístico. Un estudio comparativo.","resumen":"      El objetivo del presente artículo es  presentar un estudio comparativo de los procesos de gestión del capital humano  aplicados directamente a personas en las MiPyMEs de alojamiento turístico de la  Ciudad Autónoma de Buenos Aires y de la Ciudad de Santa Teresita, partido de la  Costa&nbsp; Atlántica, enfocándonos  específicamente en las técnicas de reclutamiento y selección de personal,  variables de estudio que se desprenden del proyecto de investigación: ?Estudio comparativo de prácticas y  tendencias de la gestión del capital humano aplicada directamente a personas en  las MiPyMEs de alojamiento turístico de Santa Teresita -Pdo. de la Costa- y  C.A.B.A. (2014-2015). Investigaciones llevadas adelante por el  mismo equipo en los períodos 2005-2009 y 2011-2013 (Barreto, Azeglio,  Cannizzaro, Lizurek, Pereyra &amp; Uriel, 2014)&nbsp;  permitieron inferir que las organizaciones identificadas carecen de  políticas o prácticas de gestión de capital humano que respondan a convenciones  formales. El desconocimiento de los procedimientos que llevan a cabo, reforzó  la necesidad e importancia de identificar en las organizaciones mencionadas,  esas prácticas y tendencias de la gestión del capital humano en general, y en  particular, las aplicadas directamente sobre las personas. La metodología empleada consistió en un  desarrollo exploratorio-descriptivo, de tipo cuali-cuantitativo, empleándose  técnicas que permiten la comparación de los datos obtenidos. Los resultados alcanzados en la  investigación del período 2011-2013 (Barreto et al., 2014)&nbsp; y los avances del actual proyecto, permiten  observar que la técnica de gestión que más se utiliza en las organizaciones  objeto de estudio, es la de reclutamiento y selección de personal.   ","palabras_clave":"Reclutamiento y selección|MiPyMEs de alojamiento turístico|Gestión del capital humano"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17933,"idioma_id":4,"titulo":"cAMP-activated Nr4a1 expression requires ERK activity and is modulated by MAPK phosphatase-1 in MA-10 Leydig cells","resumen":"In Leydig cells, LH and cAMP promote ERK1\/2 activation and MAPK phosphatase-1 (MKP-1) induction. MKP-1 up-regulation, which involves post-translational modifications such as ERK1\/2-mediated phosphorylation, reduces ERK1\/2 phosphorylation as well as Steroidogenic Acute Regulatory (StAR) protein expression and steroidogenesis. As LH- and cAMP-promoted StAR transcription requires the induction of Nur77, product of Nr4a1 gene, we analyzed the roles of ERK1\/2 and MKP-1 in 8Br-cAMP-mediated Nr4a1 expression in MA-10 Leydig cells. Pharmacological blockade of ERK1\/2 activation partially reduced the 8Br-cAMP-mediated increase in both Nr4a1 messenger levels and promoter activity. MKP-1 knock-down increased 8Br-cAMP-induced promoter activity, while its over-expression produced the opposite effect. It is concluded that Nr4a1 induction is dependent on ERK1\/2 and that MKP-1 negatively regulates this induction. Experiments based on the over-expression of MKP-1 mutated forms revealed that MKP-1 half life is determined by post-translational modifications in ERK-consensus sites, a regulation that modulates the effect of MKP-1 on Nr4a1 expression","palabras_clave":"NUR77|Nr4a1|MKP-1|Leydig cells"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17934,"idioma_id":4,"titulo":"Research on methanol tolerant catalysts for the oxygen reduction reaction","resumen":"Direct methanol fuel cells (DMFCs) generateelectricity in a clean and efficient way, so they are avaluable alternative to traditional environmentally harmfultechnologies. Portable power sources are one of the applicationsof passive DMFCs. One of the requirements inthese devices is the use of high alcohol concentration.Methanol permeation across the polymer electrolytemembrane (methanol crossover) causes a loss of fuel cellefficiency as the oxygen reduction reaction (ORR) and themethanol oxidation reaction (MOR) occur simultaneouslyat the cathode. To develop methanol-tolerant catalysts withsuitable activity, different PtM\/C and PtMRu\/C combinationswith M = Co or Fe were prepared by a modifiedimpregnation method. The synthesized catalysts werestudied to determine the role of the components in enhancingthe ORR and simultaneously discouraging theMOR. The materials were characterized by TEM, XPS andEDS. Well-distributed particles for all the catalysts wereshown by TEM. XPS spectra revealed that the methodproduces a great amount of metallic Pt. The electrochemicalcharacterization was carried out by linear sweepvoltammetry and cyclic voltammetry, in a three-electrodeelectrochemical cell with a glassy carbon rotating diskelectrode covered with a thin catalytic layer and a Nafionfilm as the working electrode. Binary and ternary catalystshave a good activity for the ORR. However, the enhancedactivity of binary catalysts is lost when the ORR is studiedin the presence of methanol. Ternary catalysts containingRu showed higher methanol-tolerance, regardless of thecomposition.","palabras_clave":"ORR|DMFC|Methanol crossover|methanol-tolerant catalyst"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17935,"idioma_id":4,"titulo":"Searching for suitable catalysts for a passive direct methanol fuel cell cathode","resumen":"Trimetallic PtMRu\/C IM cathode catalysts with M = Co or Fe obtained by an impregnation procedure using ethylene glycol and NaBH4 as reducing agent, with suitable activity for the oxygen reduction reaction (ORR) and improved tolerance to methanol, have been physically characterized by HRTEM, EDS and XPS. The examined nanoparticles have a small particle size and are well spread on the carbon support. Pt is mainly found as Pt (0) and Co, Fe and Ru are mostly oxidized.   To study their durability and performance for ORR and methanol-tolerant behavior over time, the catalysts were subjected to an electrochemical accelerated stress test (AST), consisting in cycling the potential 2000 times. Polarization curves for ORR with and without methanol were recorded. After the AST the IM catalysts are able to keep their performance for ORR in the presence of methanol.","palabras_clave":"Methanol crossover|Methanol-tolerant catalyst|Passive direct methanol fuel cells|Trimetallic catalysts|Accelerated stress test"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17936,"idioma_id":4,"titulo":"Properties and clinical utility of topotecan fluorescence: uses for retinoblastoma","resumen":"Topotecan fluoresces when exposed to ultraviolet (UV) light. Our observations with UV light in retinoblastoma cases has allowed us to minimise and manage inadvertent skin contact, guide periocular injections and leakage from such injections and document conjunctival contact after periocular injection in addition to demonstrating the drug in the vitreous after intravitreal injection. The technique is safe, inexpensive and easy to perform.","palabras_clave":"retinoblastoma|topotecan"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17937,"idioma_id":4,"titulo":"Ag nanoparticles formed by femtosecond pulse laser  ablation in water: self-assembled fractal structures","resumen":"We report for the first time on the formation of self-assembled fractals of spherical Ag nanoparticles fabricated by femtosecond (fs) pulse laser ablation of a solid silver target in water. Fractal structures grew both in 2 and 3 Euclidean dimension (d). Ramified-fractals assemblies of 2 nm height and 5-14 &#61549;m large, decorated with Ag nanoparticles of 3 nm size, were obtained in a 2d geometry when highly diluted drops of colloidal suspension were dried at a fast heating rate over a mica substrate. When less-diluted-drops were dried at slow heating rate, isolated single nanoparticles or rosette-like structures were formed. Fractal aggregates about 31 nm size in 3d geometry were observed in the as-prepared colloidal suspension.  Electron diffraction and Optical Extinction Spectroscopy (OES) analyses performed on the samples confirmed the presence of Ag and Ag2O. The analysis of the optical extinction spectrum, using the electrostatic approximation of Mie theory for small spheres, showed the existence of Ag bare core, Ag-Ag2O and air-Ag core-shell nanoparticles (Nps), being Ag-Ag2O the most frequent species (69% relative abundance).  Core-size and shell-thickness distribution was derived from OES.  In situ scattering measurements of the Ag colloidal suspension, carried out by Small Angle X-ray Scattering (SAXS), indicate a mass fractal composed of packaged   particles and fractal dimension   Ex-situ Atomic Force Microscopy imaging displayed well ramified structures, which, analyzed with box-counting method, yield a fractal dimension   The growing behaviour of these 2d and 3d self assembled fractals is consistent with the diffusion limited aggregation (DLA) model.","palabras_clave":"Ag nanoparticles|fractal|SAXS|AFM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17939,"idioma_id":5,"titulo":"Temporalidad y melancolía en Nostalgia de la luz (2010) de Patricio Guzmán","resumen":"El presente artículo propone una interpretación del film Nostalgia de la luz (2010) del documentalista chileno Patricio Guzmán tomando como hilo conductor dos conceptos: imagen-tiempo y melancolía. A partir de los desarrollos de Deleuze y Benjamin, se abordan las imágenes del film como articulación de un pensamiento acerca de la historia leída en clave de una melancolización de lo político que supone una compleja concepción del tiempo histórico.","palabras_clave":"CINE DOCUMENTAL|CINE POLÍTICO|GILLES DELEUZE|WALTER BENJAMIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17940,"idioma_id":4,"titulo":"Rotavirus VP6 protein expressed in cell culture by HSV-1-based vectors","resumen":"HSV-1 vectors were developed for the expression of several rotavirus genes. Genes from other pathogens were also expressed, thus generating a set of tools to be tested as new vaccine candidates against In this section, we show two different HSV-1 vectors that express the VP6 protein from different rotavirus strains. Figure 1 shows a defective recombinant virus expressing simultaneously EGFP and VP6 from murine rotavirus strain EC, In Figure 2, an amplicon vector overexpressing VP6 from a Wa strain of human Rotavirus is shown. In both cases, the VP6 proteins were recognized by a monoclonal antibody and were found extensively expressed forming filaments along the cells, showing a typical intra-cellular pattern, in the absence of other rotavirus proteins. These results show that the recombinant proteins maintain the specific capacity of self-assembly of the native protein and, therefore, are potential vaccine candidates to be explored.","palabras_clave":"herpesvirus vectors|rotavirus|VP6|recombinant protein"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17941,"idioma_id":4,"titulo":"Working memory differences in long-distance dependency resolution","resumen":"There is a wealth of evidence showing that increasing the distance between an argument and its head leads to more processing effort, namely, locality effects; these are usually associated with constraints in working memory (DLT: Gibson, 2000; activation-based model: Lewis and Vasishth, 2005). In SOV languages, however, the opposite effect has been found: antilocality (see discussion in Levy et al., 2013). Antilocality effects can be explained by the expectation-based approach as proposed by Levy (2008) or by the activation-based model of sentence processing as proposed by Lewis and Vasishth (2005). We report an eye-tracking and a self-paced reading study with sentences in Spanish together with measures of individual differences to examine the distinction between expectation- and memory-based accounts, and within memory-based accounts the further distinction between DLT and the activation-based model. The experiments show that (i) antilocality effects as predicted by the expectation account appear only for high-capacity readers; (ii) increasing dependency length by interposing material that modifies the head of the dependency (the verb) produces stronger facilitation than increasing dependency length with material that does not modify the head; this is in agreement with the activation-based model but not with the expectation account; and (iii) a possible outcome of memory load on low-capacity readers is the increase in regressive saccades (locality effects as predicted by memory-based accounts) or, surprisingly, a speedup in the self-paced reading task; the latter consistent with good-enough parsing (Ferreira et al., 2002). In sum, the study suggests that individual differences in working memory capacity play a role in dependency resolution, and that some of the aspects of dependency resolution can be best explained with the activation-based model together with a prediction component.","palabras_clave":"locality|antilocality|working memory capacity|individual differences|Spanish|activation|DLT|expectation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17942,"idioma_id":4,"titulo":"On the complexity of {k}-domination and k-tuple domination in graphs","resumen":" We consider two types of graph domination ---${k}$-domination and $k$-tuple domination, for a fixed positive integer $k$--- and provide new NP-complete as well as polynomial time solvable instances for their related decision problems.Regarding NP-completeness results, we solve the complexity of the ${k}$-domination  problem on split graphs, chordal bipartite graphs and planar graphs, left open in 2008. On the other hand, by exploiting Courcelle´s results on Monadic Second Order Logic, we obtain that both problems are polynomial time solvable for graphs with clique-width bounded by a constant. In addition, we give an alternative proof for the linearity of these problems on strongly chordal graphs.","palabras_clave":"{K}-DOMINATION|K-TUPLE DOMINATION|SPLIT GRAPHS|PLANAR GRAPHS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17943,"idioma_id":5,"titulo":"Criterios Planificadores del Plan Estratégico de Turismo Sustentable 'Necochea 2013 - 2023'","resumen":"La gestión ambiental de un destino turístico implica no sólo un aumento de la competitividad turística, sino que además la conservación y mejora de las características medioambientales de dicho destino. Esto significa que una planificación integral del espacio objeto de actuación debe basarse en una planificación estratégica de ordenamiento territorial que incluya las dimensiones físicas, sociales, económicas y políticas que conforman el territorio real. El objetivo principal de este trabajo fue identificar los criterios planificadores establecidos en la formulación y proyección del Plan Estratégico de Turismo Sustentable ?Necochea 2013-2023?, Argentina. Se identificaron las estrategias a adoptar para la consolidación de Necochea como destino turístico sustentable. Se utilizó el método de investigación-acción participativa, desarrollado en cuatro etapas. La primera etapa incluyó la comprensión de la problemática y los criterios planificadores subyacentes en la concepción del Plan y la lógica de intervención adoptada. La segunda consistió en la formulación del Plan, la definición de objetivos y la identificación de propuestas de los sectores sociales implicados. En la tercera etapa se consensuaron los principales elementos del Plan y se identificaron dos tipos de estrategia, específicas y transversales. La cuarta etapa de evaluación del Plan se distinguieron las condiciones de tres procesos: Internalización y territorialización de las políticas. Los principales hallazgos sugieren que el Plan facilitó el proceso de internalización de la política turística, lo cual fue legitimado desde un enfoque participativo, validando de esta manera la incidencia de la ciudadanía en la política pública de turismo. Una importante implicancia indica un efecto positivo por la divulgación de los resultados del Plan y el compromiso asumido por el gobierno local","palabras_clave":"GESTIÓN AMBIENTAL |PLANIFICACIÓN INTEGRAL |DESTINO TURÍSTICO SUSTENTABLE  |POLÍTICA TURÍSTICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17944,"idioma_id":4,"titulo":"Bioecological traits, abundance patterns and distribution extension of the soldierless Neotropical termite Compositermes vindai Scheffrahn, 2013 (Isoptera, Termitidae, Apicotermitinae).","resumen":"Abstract","palabras_clave":"ISOPTERA|APICOTERMITINAE|ANOPLOTERMES GROUP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17945,"idioma_id":4,"titulo":"ADP Ribosylation Factor 6 (ARF6) Promotes Acrosomal Exocytosis by Modulating Lipid Turnover and Rab3A Activation","resumen":"Regulated secretion is a central issue for the  specific function of many cells; for instance,  mammalian sperm acrosomal exocytosis is  essential for egg fertilization. ARF6 (ADPribosylation  factor 6) is a small GTPase implicated  in exocytosis but its downstream effectors remain  elusive. We combined biochemical, functional and  microscopy-based methods to show that ARF6 is  present in human sperm, localizes to the acrosomal  region, and is required for calcium and  diacylglycerol (DAG)-induced exocytosis. Results  from pull-down assays show that ARF6 exchanges  GDP for GTP in sperm challenged with different  exocytic stimuli. Myristoylated and GTP&#61543;S-loaded  ARF6 (active form) induces sperm exocytosis  even in the absence of extracellular calcium. We  demonstrated that ARF6 stimulates a sperm PLD  activity, to produce phosphatidic acid, and boosts  the synthesis of phosphatidylinositol 4,5-  bisphosphate (PIP2). Although both lipids are  required for exocytosis they do not induce  secretion by themselves. In this report, we  unveiled the ARF6 signaling that promotes  regulated secretion. We present, direct evidence  demonstrating that active ARF6 increases PLC  activity, causing PIP2 hydrolysis, and IP3-  dependent intraacrosomal calcium release. For the  first time, we identified a link between ARF6 and  PLC signaling. Moreover, active ARF6 increases  the exchange of GDP for GTP on Rab3A, a  prerequisite for secretion. Further, we found that  ARF6 triggers a mechanism involving novel  targets. We propose that exocytic stimuli activate  ARF6, which induces acrosomal calcium efflux  and assembles the fusion machinery leading to  membrane fusion. This report highlights the  physiological importance of ARF6 as a key  molecule for human sperm exocytosis and  fertilization.","palabras_clave":"ARF|cell signaling|exocytosis|lipid signaling"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17946,"idioma_id":4,"titulo":"Purinergic signaling modulates human visceral adipose inflammatory responses: implications in metabolically unhealthy obesity","resumen":"Obesity is accompanied by chronic inflammation of VAT,which promotes metabolic changes, and purinergic signaling has a key role in a wide range of inflammatory  diseases. Therefore, we addressed whether fat inflammation could be differentially modulated by this signaling pathway in the MUO and in individuals who remain MHO.  Our results show that the necrotized VAT of both groups released greater levels of ATP compared with lean donors. Interestingly, MUO tissue SVCs showed upregulation and engagement of the purinergic P2X7R. The extracellular ATP concentration is regulated by an enzymatic process, in which CD39 converts ATP and ADP into AMP, and CD73 converts AMP into adenosine. In VAT, the  CD73 ectoenzyme was widely distributed in immune and nonimmune cells, whereas CD39 expression was restricted to immune CD45PAN+ SVCs. Although the MUO  group expressed the highest levels of both ectoenzymes, no difference in ATP hydrolysis capacity was found between the groups. As expected, MUO exhibited the  highest NLRP3 inflammasome expression and IL-1b production.  MUO SVCs also displayed up-regulation of the A2AR, allowing extracellular adenosine to increase IL-1b local secretion. Additionally, we demonstrate that metabolic parameters and BMI are positively correlated with purinergic components in VAT. These findings indicate that purinergic signaling is a novel mechanism involved in the chronic inflammation of VAT underlying the metabolic  changes in obesity. Finally, our study reveals a proinflammatory role for adenosine in sustaining IL-1b production in this tissue.","palabras_clave":"Obesidad|Enfermedad Metabolica|ATP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17947,"idioma_id":4,"titulo":"Mass spectrometry and theoretical calculations about the loss of Methyl radical from methoxilated coumarins","resumen":"..","palabras_clave":"MASS SPECTROMETRY|COUMARINS|DFT CALCULATION|QTAIM|NBO METHOD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17948,"idioma_id":4,"titulo":"New insights into the wheat chromosome 4D structure and virtual gene order, revealed by survey pyrosequencing","resumen":"Survey sequencing of the bread wheat (Triticum aestivum L.) genome (AABBDD) has been approached through different strategies delivering important information. However, the current wheat sequence knowledge is not complete. The aim of our study is to provide different and complementary set of data for chromosome 4D. A survey sequence was obtained by pyrosequencing of flow-sorted 4DS (7.2×) and 4DL (4.1×) arms. Single ends (SE) and long mate pairs (LMP) reads were assembled into contigs (223 Mb) and scaffolds (65 Mb) that were aligned to Aegilops tauschii draft genome (DD), anchoring 34 Mb to chromosome 4. Scaffolds annotation rendered 822 gene models. A virtual gene order comprising 1973 wheat orthologous gene loci and 381 wheat gene models was built. This order was largely consistent with the scaffold order determined based on a published high density map from the Ae. tauschii chromosome 4, using bin-mapped 4D ESTs as a common reference. The virtual order showed a higher collinearity with homeologous 4B compared to 4A. Additionally, a virtual map was constructed and &#8764;5700 genes (&#8764;2200 on 4DS and &#8764;3500 on 4DL) predicted. The sequence and virtual order obtained here using the 454 platform were compared with the Illumina one used by the IWGSC, giving complementary information.","palabras_clave":"Genome|Bioinformatics|Wheat"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17949,"idioma_id":5,"titulo":"Desempeño de varones y mujeres en relación con el razonamiento visuoespacial. Influencia de la velocidad de respuesta, la educación y la presencia de rotación en los ítems","resumen":"En este estudio se pone a prueba la hipótesis sobre las diferencias de género en el rendimiento frente a pruebas de habilidad visuoespacial y se detalla el análisis de posibles factores intervinientes como la velocidad de respuesta, la presencia de la regla de rotación en los reactivos y la educación secundaria. Se utilizó un Test de Analogías Figurales previamente calibrado y modelizado con la Teoría Clásica de Tests y la Teoría de Respuesta al Ítem. Se tomaron dos muestras con 475 protocolos depurados de estudiantes de Psicología y 1,129 de estudiantes de carreras artísticas y de diseño. Sus medias de edad fueron respectivamente 21.87 y 21.32. Las mujeres ocuparon el 80% de la primera muestra y el 53% de la segunda aproximadamente. A nivel general, los varones obtuvieron puntajes medios significativamente mayores que los de las mujeres, pero el tamaño del efecto varía de acuerdo a los factores intervinientes.","palabras_clave":"DISCREPANCIA|COMPARACIÓN|SEXO|APTITUD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17950,"idioma_id":4,"titulo":"Genetic diversity within and among two Argentinean and  one Mexican species of Acacia (Fabaceae)","resumen":"p { margin-bottom: 0cm; direction: ltr; color: rgb(0, 0, 0); text-align: justify; widows: 2; orphans: 2; }p.western { font-family: 'Times New Roman',serif; font-size: 16pt; }p.cjk { font-family: 'Times New Roman',serif; font-size: 16pt; }p.ctl { font-family: 'Times New Roman',serif; font-size: 12pt; }a:link { color: rgb(0, 0, 255); }          Acacia  is a pantropical genus comprising more than 1450 species. Following  Vassal?s treatment  Acacia  is considered as a single genus with three subgenera (Acacia,  Aculeiferum  and Phyllodineae).  A. caven,  A. curvifructa  and A. farnesiana belong  to the subgenus Acacia  and the relationship between them is controversial. The aim of this  study is to elucidate the relationship between the three species by  means of AFLP technique analysing nine populations of these species  and to compare the results obtained with those of morphological  analysis. The genetic  diversity indices (PLP,  H) showed  that genetic variation in A.  caven is  higher of that found in A.  curvifructa  and A.  farnesiana.  Of the total genetic diversity most  part is represented within populations (~60%). The analysis with  STRUCTURE showed that the optimal number of clusters (K)  was 6 and in all cases where populations were grouped they were  geographically close and\/or belong to the same variety. The  morphological CDA did not result in a separation between all  individuals,  indicating  that they do not harbour  consistent morphological discontinuities. Altogether,  the results of our molecular analyses showed the existence of  significant differences between A.  caven, A.  curvifructa and A.  farnesiana, which argues for  recognizing them as different species.","palabras_clave":"AFLP|GENETIC DIFFERENTIATION|GENETIC STRUCTURE|ARGENTINA|MEXICO|MORPHOLOGICAL DIFFERENTIATION|MORPHOLOGICAL VARIATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17951,"idioma_id":4,"titulo":"Electronic, structural, and hyperfine properties of pure and Cd-doped hexagonal La2O3 semiconductor","resumen":"                            We present a detailed  first-principles study of structural, electronic, and hyperfine properties of  pure and Cd-doped lanthanum sesquioxide (La2O3) with the  hexagonal structure (A-phase). We  calculated the equilibrium structure, the density of states (DOS), the energy  band-gap and, finally, the electric-field-gradient (EFG) tensor at the  different atomic sites (La, O, and Cd at substitutional La sites) using different  approximations for the exchange and correlation potential. In the case of pure A-La2O3 our  predictions are compared with available experimental data obtained in X-ray  Diffraction experiments and Nuclear Quadrupole Resonance and Nuclear Magnetic  Resonance spectroscopies. The excellent agreement between theory and  experiments gave us a solid base for the study of Cd-doped A-La2O3. In the case of the doped system, a  very good agreement between the predicted and the experimental EFG at the 111Cd  sites (obtained in Time-Differential Perturbed g-g Angular Correlations experiments) was found. From the comparison of the  EFGs obtained at different probe sites we can discuss and elucidate the role  played by the electronic structure of the probe atoms, and the structural and  electronic modifications induced by the Cd impurity in the La2O3  host, on the origin of the EFG.             ","palabras_clave":"Lanthanum oxide|Hyperfine interactions|Electric-field-gradient|DFT calculations|Doped semiconductor|Perturbed angular correlations"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17953,"idioma_id":4,"titulo":"Isolation and characterization of 20 polymorphic microsatellite loci in the migratory freshwater fish Leporinus obtusidens (Characiformes: Anostomidae) using 454 shotgun pyrosequencing","resumen":"Twenty polymorphic microsatellite markers were developed for the Neotropical fish Leporinus  obtusidens using a next generation sequencing approach and tested in two other characifomes  species, Schizodon platae and Prochilodus lineatus. Microsatellite loci alleles in L. obtusidens ranged  between 2 and 20 alleles per locus (mean=5&#8901;7), with expected heterozygosity values ranging from  0&#8901;097 to 0&#8901;956 (mean=0&#8901;578) and observed heterozygosity values ranging from 0&#8901;000 to 0&#8901;800  (mean=0&#8901;400) in a sample of 20 specimens from the lower Paraná River (Argentina). Most of these  markers will be a valuable tool for captive breeding and stocking programmes, as well as for analyses  of population connectivity and genetic structure in this broadly distributed Neotropical migratory fish.","palabras_clave":"NEOTROPICAL FISH|PARANA RIVER|PROCHILODUS LINEATUS|SCHIZODON PLATAE|BOGA|MOLECULAR MARKER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17954,"idioma_id":4,"titulo":"Intraspecific variation of insertion\/length of stamens in homostylous flowers of a new species and three other species of Borreria: an unusual case in Rubiaceae","resumen":"Four species of Borreria subsection Latifoliae (Rubiaceae) present intrafloral variations in the  insertion\/length of stamens in homostylous flowers. Borreria heteranthera is described and  illustrated as new species from the state of Pará, Brazil. The emended descriptions of Borreria  hispida, B. semiamplexicaule and B. xanthophylla, with details on stamens morphology and  insertion, are provided. The inclusion of B. xanthophylla in the subsection Latifoliae is proposed.  Staminal arrangement, pollen grains and seed morphology of the four species are compared. A  comparative table with ecological, palynological, and morphological features of each species is  provided. In addition, Borreria semiamplexicaule is mentioned as a new record for the state of Mato  Grosso, Brazil, and the lectotype of B. hispida is here designated.","palabras_clave":"Borreria|Spermacoce|Spermacoceae|Brazil"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17955,"idioma_id":4,"titulo":"Conformational properties of ethyl- and 2,2,2-trifluoroethyl thionitrites, (CX3CH2SNO, X= F and H)","resumen":"The simple 2,2,2-trifluoroethyl thionitrite molecule, CF3CH2SNO, has been prepared in good yield for the first time using CF3CH2SH and NOCl in slight excess. The vapor pressure of the red-brown compound CF3CH2SNO follows, in the temperature range between 226 and 268 K, the equation log p = 12.0 + 3881\/T (p\/bar, T\/K), and its extrapolated boiling point reaches 51 °C. Its structural and conformational properties have been compared with the ethyl thionitrite analogue, CH3CH2SNO. The FTIR spectra of the vapor of both thionitrites show the presence of bands with well-definedcontours, allowing for a detailed conformational analysis and vibrational assignment on the basis of a normal coordinate analysis. The conformational space of both thionitrite derivatives has also been studied by using the DFT and MP2(full) level of theory with extended basis sets [6-311+G(2df) and cc-pVTZ]. The overall evaluation of the experimental and theoretical results suggests the existence of a mixture of two conformers at room temperature. The relative abundance of the most stable syn form (N=O double bond syn with respect to the C?S single bond) has been estimated to be ca. 79 and 75 % for CF3CH2SNO and CH3CH2SNO, respectively.","palabras_clave":"THIONITRITE|CONFORMATION|VIBRATIONAL PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17956,"idioma_id":5,"titulo":"EMPLEO DE CASOS PROFESIONALES PARA LA ENSEÑANZA DE GENÉTICA EN VETERINARIA","resumen":"La carrera Medicina Veterinaria ofrece un campo profesional muy amplio, lo que condiciona la variedad de contenidos requeridos en Genética. Esta ciencia posee naturaleza abstracta y su estudio demanda integración y relación con múltiples contenidos disciplinares. Las estrategias de resolución de problemas favorecen el desarrollo de capacidades intelectuales, pero deben ser trabajadas con estudiantes que posean interés en su aprendizaje. En las cohortes 2005-2010, se observaron índices de rendimiento académico fluctuantes y un alto porcentaje de deserción. De acuerdo con esta situación se implementaron dos estrategias fundamentales: la utilización de casos de la práctica profesional, una de carácter clínico y otro de carácter productivo, que involucraban una causa genética, con el fin de motivar a los estudiantes para el estudio de esta ciencia, al observar su aplicación. A partir de estos, se plantearon situaciones problemáticas con la finalidad de mejorar la comprensión e integración de contenidos para optimizar el rendimiento académico. Esta propuesta pedagógica acrecentó el interés por la asignatura, generando participación activa y voluntaria en su aprendizaje. Las calificaciones mejoraron, aumentó el número de alumnos aprobados y disminuyó el índice de deserción. Los estudiantes fueron aproximados a un aprendizaje autónomo que les permitió integrar contenidos propios de la asignatura, obteniendo competencias para el desarrollo profesional. Entre los docentes de las asignaturas involucradas se llevó a cabo un trabajo colaborativo e interdisciplinario que permitió otorgar en Genética un enfoque aplicado a la práctica profesional mediante el estudio clínico de una enfermedad canina y la resolución de un caso de infertilidad en bovinos.","palabras_clave":"ENSEÑANZA|GENÉTICA|CASOS PROFESIONALES|PROPUESTA DIDÁCTICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17957,"idioma_id":5,"titulo":"Análisis de perfiles de personalidad en mujeres adultas con diagnóstico de Síndrome de Turner","resumen":"El Síndrome de Turner es el trastorno cromosómico, no heredable, de mayor incidencia poblacional en el sexo femenino, determinado por la deleción parcial o total del cromosoma X.  En el desarrollo de las mujeres con este diagnóstico intervienen factores genéticos, familiares, educacionales y sociales que resultan relevantes en la consolidación de la personalidad. El objetivo del presente trabajo fue caracterizar la personalidad de mujeres adultas con Síndrome de Turner residentes en Latinoamérica. La muestra fue de tipo no probabilístico intencional y corresponde a 60 mujeres entre 18 y 55 años. Los datos se recabaron a través de una versión virtual del Inventario Clínico Multiaxial de Millón II. Se transformaron las puntuaciones directas en puntuaciones Tasa Base y se obtuvieron estadísticos descriptivos de frecuencias y medidas de tendencia central para caracterizar a las participantes de la muestra. Posteriormente se calculo la razón de momios para obtener el índice de la probabilidad que las mujeres con diagnóstico de Síndrome de Turner presentaran trastornos de la personalidad. Los resultados obtenidos muestran que la probabilidad que presenta dicha población de padecer trastornos de personalidad, en comparación con una muestra clínica normativa, resulta superior para todos los trastornos, siendo las escalas autodestructiva, compulsiva y antisocial aquellas que presentan los porcentajes más altos. Los datos obtenidos dan cuenta de la vulnerabilidad que presenta la población estudiada de padecer trastornos de personalidad y son útiles para el desarrollo de terapias específicas que consideren dichas características en pos de una mejor calidad de vida.","palabras_clave":"SÍNDROME DE TURNER|PERSONALIDAD|MILLON|MCMI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17958,"idioma_id":5,"titulo":"Análisis de procesos mnésicos en mujeres con diagnóstico de Síndrome de Turner. Implicancias teóricas y clínicas","resumen":"El presente trabajo se propuso caracterizar el perfil de desempeño mnésico en mujeres con diagnóstico de Síndrome de Turner, trastorno genético cuya expresión origina una morfología cerebral atípica que afecta estructuras corticales y subcorticales involucradas en la memoria. Para la evaluación de los procesos mnésicos se administró el Test de Aprendizaje Verbal España-Complutense en sus dos versiones adultos y niños\/adolescentes, y una prueba experimental de reconocimiento de fuente, basada en el paradigma de disociación de procesos. La muestra fue intencional, 23 mujeres con diagnóstico de Síndrome de Turner y sus respectivos controles. Los resultados dan cuenta de un  perfil mnésico diferencial con déficits en los procesos de recuerdo y no en los de reconocimiento. Se hipotetiza la existencia de falencias en la implementación de criterios de codificación y búsqueda organizados y eficaces, que hayan limitado el recuerdo de información. Determinar los déficits mnésicos diferenciales en mujeres con diagnóstico de Síndrome de Turner, permitiría el diseño de intervenciones clínicas y psicoeducativas tendientes a potenciar estrategias mnesicas que optimicen el rendimiento global del proceso, favoreciendo el aprendizaje.","palabras_clave":"SÍNDROME DE TURNER|PROCESOS MNÉSICOS|FAMILIARIDAD|RECOLECCIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17959,"idioma_id":4,"titulo":"Decoherence of a solid-state qubit by different noise correlation spectra","resumen":"The interaction between solid-state qubits and their environmental degrees of freedom produces non- unitary effects like decoherence and dissipation. Uncontrolled decoherence is one of the main obstacles that must be overcome in quantum information processing. We study the dynamical decay of coherences in a solid-state qubit by means of the use of a master equation. We analyse the effects induced by thermal ohmic environments and low-frequency 1\/f noise. We focus on the effect of longitudinal and transversal noise on the superconducting qubit?s dynamics. Our results can be used to design experimental future setups when manipulating superconducting qubits.","palabras_clave":"Decoherence|Solid-state"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17960,"idioma_id":4,"titulo":"Effect of concurrent geometry and roughness in interacting surfaces","resumen":"We study the interaction energy between two surfaces, one of them flat, the other describable as the composition of a small-amplitude roughness and a slightly curved, smooth surface. The roughness, represented by a spatially random variable, involves Fourier wavelengths shorter than the (local) curvature radii of the smooth component of the surface. After averaging the interaction energy over the roughness distribution, we obtain an expression which only depends on the smooth component. We then approximate that functional by means of a derivative expansion, calculating explicitly the leading- and next-to-leading-order terms in that approximation scheme. We analyze the resulting interplay between shape and roughness corrections for some specific roughness models in the cases of electrostatic and Casimir interactions.","palabras_clave":"Casimir effect|Derivative expansion|Roughness effect"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17961,"idioma_id":4,"titulo":"Alcohol Odor Elicits Appetitive Facial Expressions in Human Neonates Prenatally Exposed to the Drug","resumen":"Specific memories arise during prenatal life as a function of fetal processing of chemosensory stimuli present in the amniotic fluid. Preclinical studies indicate that fetal exposure to alcohol modifies subsequent neonatal and infantile responsiveness towards the sensory attributes of the drug. It has been previously demonstrated that 1-2day-old human neonates recognize ethanol odor as a function of moderate maternal alcohol consumption during gestation. In the present study 7-14day-old newborns were assessed in terms of behavioral responsiveness to alcohol's chemosensory attributes or to a novel odor (lemon). These newborns were representative of mothers that exhibited infrequent or frequent alcohol drinking patterns during pregnancy. Different clinical assessments indicated that all newborns did not suffer congenital or genetic diseases and that they were completely healthy when behaviorally evaluated. Testing was defined by brief presentations of ethanol or lemon odorants. Two sequences of olfactory stimulation were employed. One sequence included five initial trials defined by ethanol odor stimulation followed by one trial with lemon and five additional trials with the scent of the drug (EtOH-Lem-EtOH). The alternative sequence (Lem-EtOH-Lem) was primarily defined by lemon olfactory exposure. The dependent variables under analysis were duration and frequency of overall body movements and of facial expressions categorized as aversive or appetitive. The main results of this study were as follows: a) at the end of the testing procedure and independent of the sequence of olfactory stimulation, babies born to frequent drinkers exhibited signs of distress as operationalized through higher durations of aversive facial expressions, b) despite this effect, babies born to frequent drinkers relative to newborns delivered by infrequent drinkers exhibited significantly higher frequencies of appetitive facial responses when primarily stimulated with ethanol odor (EtOH-Lem-EtOH sequence) and c) when merging both samples of babies, a positive and significant correlation was found between overall maternal absolute alcohol consumption per month and frequency of appetitive facial expressions elicited by alcohol odor. In conjunction with previous preclinical research, the present results indicate that human prenatal exposure to the drug that yields no evident teratological effects is sufficient to modify the hedonic value of alcohol's chemosensory attributes. ","palabras_clave":"Ethanol olfactory stimulation|Facial expressions|Fetal ethanol exposure|Human neonates"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17962,"idioma_id":4,"titulo":"First insight into divergence, representation and chromosome distribution of reverse transcriptase fragments from L1 retrotransposons in peanut and wild relative species","resumen":"Peanut is an allotetraploid (2n = 2x = 40, AABB) of recent origin. Arachis duranensis and A. ipaënsis, the most probable diploid ancestors of the cultigen, and several other wild diploid species with different genomes (A, B, D, F and K) are used in peanut breeding programs. However, the genomic relationships and the evolutionary pathways of genome differentiation of these species are poorly understood. We performed a sequence-based phylogenetic analysis of the L1 reverse transcriptase and estimated its representation and chromosome distribution in species of five genomes and three karyotype groups with the aim of contributing to the knowledge of the genomic structure and evolution of peanut and wild diploid relatives. All the isolated rt fragments were found to belong to plant L1 lineage and were named ALI. The best supported phylogenetic groups were not concordant with the genomes or karyotype groups. The copy number of ALI sequences was higher than the expected one for plants and directly related to genome size. FISH experiments revealed that ALI is mainly located on the euchromatin of interstitial and distal regions of most chromosome arms. Divergence of ALI sequences would have occurred before the differentiation of the genomes and karyotype groups of Arachis. The representation and chromosome distribution of ALI in peanut was almost additive of those of the parental species suggesting that the spontaneous hybridization of the two parental species of peanut followed by chromosome doubling would not have induced a significant burst of ALI transposition.","palabras_clave":"Arachis genomes|peanut|LINEs|reverse transcriptase|fluorescent in situ hybridization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17963,"idioma_id":4,"titulo":"An unconstrained optimization approach to empirical mode decomposition","resumen":"Empirical mode decomposition (EMD) is an adaptive (data-driven) method to decompose non-linear and non-stationary signals into AM-FM components. Despite its well-known usefulness, one of the major EMD drawbacks is its lack of mathematical foundation, being defined as an algorithm output. In this paper we present an alternative formulation for the EMD method, based on unconstrained optimization. Unlike previous optimization-based efforts, our approach is simple, with an analytic solution, and its algorithm can be easily implemented. By making no explicit use of envelopes to find the local mean, possible inherent problems of the original EMD formulation (such as the under- and overshoot) are avoided. Classical EMD experiments with artificial signals overlapped in both time and frequency are revisited, and comparisons with other optimization-based approaches to EMD are made, showing advantages for our proposal both in recovering known components and computational times. A voice signal is decomposed by our method evidencing some advantages in comparison with traditional EMD and noise-assisted versions. The new method here introduced catches most flavors of the original EMD but with a more solid mathematical framework, which could lead to explore analytical properties of this technique.","palabras_clave":"Empirical mode decomposition (EMD)|Convex optimization|Time frequency|Data-driven methods"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17964,"idioma_id":4,"titulo":"Influence of freezing temperature and maltodextrin concentration on stability of linseed oil-in-water multilayer emulsions","resumen":"The effect of maltodextrin (MDX) concentration on the stability of multilayer linseed oil-in-water emulsions before and after freeze-thawing has been studied. Interfacial double-layer emulsions were obtained by performing electrostatic deposition of sodium alginate (SA) onto whey protein isolate (WPI) coated oil droplets at pH 5 (10 wt% oil, 1 wt% WPI 0.25 wt% SA). MDX was also added to emulsions formulation in different concentrations (0-20 wt%), and the systems were then stored at two freezing temperatures (-18 and -80°C). Stability of emulsions was studied using droplet size, &#950;-potential, as well as microstructure determinations and monitoring backscattering profiles versus time. Non-frozen emulsions showed smaller droplet sizes at higher MDX concentrations thus reducing creaming mechanisms and improving emulsion stability. In the absence of MDX, emulsions were highly unstable after freeze-thawing and destabilized faster at -18°C than at -80°C, which was attributed to the formation of larger ice crystals at slower freezing rates that promoted interfacial membrane disruption leading to extensive droplet coalescence and oiling off. Both systems showed macroscopic phase separation within the first hour of analysis. The addition of MDX greatly improved emulsion stability after freezing, as emulsions showed no phase separation after thawing during one week storage. This behaviour was attributed to MDX cryoprotectant effect, that could have considerably reduce the amount of ice formed during freezing, thereby maintaining the integrity of the interfacial WPI-SA bilayer surrounding oil droplets. Our results suggest that 20 wt% MDX emulsions were the most stable systems both to creaming destabilization and to freeze-thawing processes.","palabras_clave":"Multilayer emulsion|Layer by layer deposition|Linseed oil|Whey protein|Alginate|Maltodextrin"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17965,"idioma_id":5,"titulo":"Perspectivas arqueológicas para Patagonia Septentrional:  sitio Cueva Huenul 1 (provincia del Neuquén, Argentina)","resumen":"El norte de la provincia de Neuquén (Depto. Pehuenches, Argentina) es muy poco conocido a nivel arqueológico, a pesar de estar ubicado en una posición central en relación con distintos temas clave del poblamiento humano de Sudamérica, incluyendo la extinción de la megafauna y sus causas, el poblamiento humano inicial y la existencia de discontinuidades arqueológicas en el Holoceno medio. En este trabajo se presenta el primer cuerpo de resultados paleoecológicos y arqueológicos para el sitio Cueva Huenul 1, recientemente excavado, que ofrece una secuencia sedimentaria que se extiende durante los últimos 16.000 años calendáricos. Estas evidencias incluyen el desarrollo de un marco crono-estratigráfico para el sitio, que aporta novedosa información tefro-cronológica. A partir de este análisis, se definen cuatro componentes temporales, sobre los cuales se asienta el estudio de los materiales recuperados: evidencias faunísticas (paleontológicas y arqueológicas), arqueobotánicas, líticas, cerámicas y de arte rupestre. Estos resultados en escala de sitio proveen una primera instancia de evaluación de procesos en escala macro-regional, así como las bases para la continuación de este proyecto.","palabras_clave":"NEUQUEN|FAUNA EXTINTA|POBLAMIENTO HUMANO TEMPRANO|CRONOLOGIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17966,"idioma_id":4,"titulo":"Relaxation to one-dimensional postglottal flow in a vocal fold model","resumen":"Postglottal flow in low-order dynamical systems modeling vocal fold motion is customarily considered one-dimensional. A relaxation  distance is however mandatory before the flow effectively complies with this approximation. A continuous vocal fold model is used to  show that this relaxation distance can impact voice simulation through the coupling strength between source and tract. The degree of  interaction raises if relaxation occurs closer to the glottis, introducing complexity in the response of the system.","palabras_clave":"Aeroacustica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17967,"idioma_id":4,"titulo":"Frequency-selection mechanism in incompressible open-cavity flows via reflected instability waves","resumen":"We present an alternative perspective on nonharmonic mode coexistence, commonly found in the shear  layer spectrum of open-cavity flows. Modes obtained by a local linear stability analysis of perturbations to  a two-dimensional, incompressible, and inviscid sheared flow over a cavity of finite length and depth were  conditioned by a so-called coincidence condition first proposed by Kulikowskii [J. Appl. Math. Mech. 30, 180  (1966)] which takes into account instability wave reflection within the cavity. The analysis yields a set of discrete,  nonharmonic frequencies, which compare well with experimental results [Phys. Fluids 20, 114101 (2008); Exp.  Fluids 50, 905 (2010)].","palabras_clave":"Flow Instabilities"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17968,"idioma_id":4,"titulo":"Defining the Resource Perspective in the Development of Processes-Aware Information Systems","resumen":"Context  The resource perspective has impact on the performance of business processes. However, current Workflow Management Systems (WfMSs) provide disparate support to its implementation and business process modeling languages provide limited capabilities for its definition. Thus, it is difficult to specify requirements regarding this perspective and to select an appropriate WfMS to support them in order to obtain a technological solution aligned with the organizational needs.  Objective  To provide support to the definition, implementation, verification and validation of resource perspective requirements in the development of Process-Aware Information Systems (PAISs) based on WfMSs.  Method  The following activities were carried out: (i) identification of resource perspective aspects in executable workflow specifications, (ii) analysis of the elements provided by the BPMN modeling language to represent these aspects, (iii) development of a framework based on BPMN for defining and implementing these aspects by using the extension mechanism provided by this language, (iv) development of a model-driven development method that leverages the framework to develop PAISs, and (v) validation of the proposed framework and method through the development of a tool supporting them, a case study, and the evaluation against the Workflow Resource Patterns.  Results  A framework, a method and a tool that support the definition of the resource perspective in the development of PAISs.  Conclusion  By using the proposed framework and method, practitioners are able to: define the resource perspective requirements in conceptual process models, select a WfMS as implementation platform, and define the implementation of these requirements maintaining the consistency between the conceptual process models and the workflow specifications.","palabras_clave":"Process-aware information system|Resource perspective|Workflow|BPMN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17969,"idioma_id":4,"titulo":"Interaction between a laminar starting immersed micro-jet and a parallel wall","resumen":"In the present work, we study the starting transient of an immersed micro-jet in close vicinity to a solid wall parallel to its axis. The experiments concern laminar jets (Re < 200) issuing from a 100 &#956;m internal tip diameter glass micro-pipette. The effect of the confinement was studied placing the micro-pipette at different distances from the wall. The characterization of the jet was carried out by visualizations on which the morphology of the vortex head and trajectories was analyzed. Numerical simulations were used as a complementary tool for the analysis. The jet remains stable for very long distances away from the tip allowing for a similarity analysis. The self-similar behavior of the starting jet has been studied in terms of the frontline position with time. A symmetric and a wall dominated regime could be identified. The starting jet in the wall type regime, and in the symmetric regime as well, develops a self-similar behavior that has a relative rapid loss of memory of the preceding condition of the flow. Scaling for both regimes are those that correspond to viscous dominated flows.","palabras_clave":"Microjet|Transient|Laminar|Lateral confinement"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17970,"idioma_id":4,"titulo":"Indigenous Starter Cultures to Improve Quality of Artisanal Dry Fermented Sausages from Chaco (Argentina)","resumen":"Lactic acid bacteria (LAB) and coagulase negative cocci (CNC) were isolated from artisanal dry sausages sampled from the northeastern region of Chaco, Argentina. In order to evaluate their performance in situ and considering technological features of the isolated strains, two mixed selected autochthonous starter cultures (SAS) were designed: (i) SAS-1 (Lactobacillus sakei 487 + Staphylococcus vitulinus C2) and (ii) SAS-2 (L. sakei 442 + S. xylosus C8). Cultures were introduced into dry sausage manufacturing process at a local small-scale facility. Microbiological and physicochemical parameters were monitored throughout fermentation and ripening periods, while sensory attributes of the final products were evaluated by a trained panel. Lactic acid bacteria revealed their ability to colonize and adapt properly to the meat matrix, inhibiting the growth of spontaneous microflora and enhancing safety and hygienic profile of the products. Both SAS showed a beneficial effect on lipid oxidation and texture of the final products. Staphylococcus vitulinus C2, from SAS-1, promoted a better redness of the final product. Sensory profile revealed that SAS addition preserved typical sensory attributes. Introduction of these cultures could provide an additional tool to standardize manufacturing processes aiming to enhance safety and quality while keeping typical sensory attributes of regional dry fermented sausages.","palabras_clave":"Lactic acid bacteria|fermented sausages|bacteriocinas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17971,"idioma_id":4,"titulo":"ANALGESIA ENHANCEMENT AND PREVENTION OF TOLERANCE TO MORPHINE: BENEFICIAL EFFECTS OF COMBINED THERAPY WITH OMEGA 3 FATTY ACIDS","resumen":"Objectives Recent evidence associates omega-3 fatty acids (O3) with pain reduction.The aim of this work was to evaluate the antinociceptive effect of O3, eitheralone or in combination with morphine after acute and chronic administration inrats. As well, a new pharmaceutical mixture that allows the concomitant administrationof O3 and morphine as an oral solution was developed.Methods Animals were fed on a control or an experimental diet supplementedwith O3. They were subjected to the hot-plate test to assess analgesic effect andtolerance to the analgesic effect of morphine. The open-field test was carried out to determine if the differences in the response latency can be related to nonspecificsedative effects.Key findings O3 dietary supplementation increased the response latency compared with the control group. Acute treatment with morphine in these groups resulted in an additive antinociceptive effect not related to locomotor activity.Chronic coadministration of morphine with O3 attenuated the development of tolerance. Oral administration of the new pharmaceutical mixture showed analgesi activity with a subtherapeutic dose of morphine. Conclusion This finding suggests a role for O3 as adjuncts to opioids in pain therapy and might contribute to the reduction of the occurrence of morphine side-effects.","palabras_clave":"FISH OIL|OMEGA-3 FATTY ACIDS|TOLERANCE|HOT-PLATE TEST"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17972,"idioma_id":5,"titulo":"Análisis de la Efectividad de la Protección Jurídica del Software en las Modernas Legislaciones. Tendencias Actuales","resumen":"Las tecnologías digitales permiten la  transmisión y utilización de todos los materiales protegidos por el derecho de  autor y los derechos conexos en redes interactivas.&nbsp; La transmisión de textos, sonidos, imágenes y  programas informáticos por Internet se ha convertido en moneda corriente,  eliminando las barreras del espacio y el tiempo, facilitando una comunicación  ubicua y asincrónica. Si no se establecen normas jurídicas apropiadas, la  tecnología digital podría utilizarse para socavar los principios básicos del  derecho de autor. En consecuencia es necesario un marco jurídico adecuado que  establezca una competencia equilibrada que proporcione incentivos a los  creadores, artistas intérpretes o ejecutantes y productores locales, que apoye  a las industrias de software y aliente la creación de nuevas industrias similares.  El presente trabajo tiene por objeto analizar la protección legal del software  en la mayoría de las legislaciones internas así como en el ámbito internacional  y su eficacia&nbsp; ","palabras_clave":"SOFTWARE|HARDWARE|DERECHO DE AUTOR|DERECHO DE PROPIEDAD INTELECTUAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17973,"idioma_id":4,"titulo":"Projective resolutions of associative algebras and ambiguities","resumen":"The aim of this article is to give a method to construct bimodule resolutionsof associative algebras, generalizing Bardzell´s well-known resolution of monomial algebras.We stress that this method leads to concrete computations, providing thus a useful tool forcomputing invariants associated to the considered algebras. We illustrate how to use it bygiving several examples in the last section of the article. In particular we give necessary andsucient conditions for noetherian down-up algebras to be 3-Calabi-Yau.","palabras_clave":"Hochschild|cohomology|resolution"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17974,"idioma_id":4,"titulo":"Geomorphological-related heterogeneity as reflected in tree growth and its relationships with climate of Monte Desert Prosopis flexuosa DC woodlands","resumen":"Desert forests grow under diverse ecological conditions, mainly resulting from spatial heterogeneity of drylands with consequences on tree growth and its interactions&nbsp;with climate. In the Monte Desert, geomorphological processes generate landform and soil variability, determining the distribution and growth of plants species. Prosopis flexuosa DC,, a dominant tree species in the Central Monte Desert, grows in territories characterized by a high variability of landform and soil. We applied classical dendrochronological and statistical analysis to disentangle the effect of spatial heterogeneity upon the species radial growth and its further relation with precipitation fluctuations. ","palabras_clave":"DENDROCIMATOLOGY|ECOLOGICAL GRADIENT|SEMI-ARID WOODLANDS|TREE-RING VARIABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17975,"idioma_id":4,"titulo":"Molecular characterization and interactome analysis of Trypanosoma cruzi Tryparedoxin II","resumen":"Trypanosoma cruzi, the causative agent of Chagas disease, possesses two tryparedoxins(TcTXNI and TcTXNII), belonging to the thioredoxin superfamily. TXNs are oxidoreductases which mediate electron transfer between trypanothione and peroxiredoxins. This constitutes a difference with the host cells, in which these activities are mediated by thioredoxins, and this difference makes TXNs an attractive target for drug development. In a previous work we characterized TcTXNI, including the redox interactome. In this work we extend the study to TcTXNII. We demonstrate that TcTXNII is a transmembrane protein anchored to the surface of the mitochondria and endoplasmic reticulum, with a cytoplasmatic orientation of the redox domain, and expressed during the metacyclogenesis process. In order to continue with the characterization of the redox interactome of T. cruzi, we designed an active site mutant TcTXNII lacking the resolving cysteine, and through the expression of this mutant protein and incubation with T. cruzi proteins, heterodisulfide complexes were isolated by affinity chromatography and identified by mass spectrometry. This allowed us to identify sixteen TcTXNII interacting proteins, which are involved in a wide range of cellular processes, indicating the relevance of TcTXNII, and contributing to our understanding of the redox interactome of T. cruzi.  85","palabras_clave":"Trypanosoma cruzi|Tryparedoxin|Redox metabolism|Redox interactome"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17976,"idioma_id":5,"titulo":"Géneros y formación ingenieril: de la universidad a la industria","resumen":"En las últimas décadas, ha crecido el interés por las producciones discursivas de la formación académica. El objetivo de este artículo es presentar el repertorio y la distribución de los géneros demandados durante el ciclo específico de una carrera de Ingeniería Industrial en una universidad argentina. Los análisis de frecuencias y de distribución muestran una tendencia a la incorporación gradual de tareas del contexto industrial. Se evidencia una preponderancia del saber práctico y un interés por la inmersión temprana del estudiante en el ámbito técnico-profesional. Asimismo, se identifican aspectos cuya revisión podría contribuir al mejoramiento de las prácticas de enseñanza.","palabras_clave":"EDUCACIÓN SUPERIOR|INGENIERÍA|GÉNEROS ACADÉMICOS|GÉNEROS PROFESIONALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17977,"idioma_id":4,"titulo":"Overexpression of a phosphatidic acid phosphatase type 2 leads to an increase in triacylglycerol production in oleaginous Rhodococcus strains","resumen":"Oleaginous Rhodococcus strains are able to accumulate large amounts of triacylglycerols (TAG). Phosphatidic acid phosphatase enzyme (PAP) catalyzes the dephosphorylation of phosphatidic acid (PA) to yield diacylglycerol (DAG), a key precursor for TAG biosynthesis. Studies to establish its role in lipid metabolism have been mainly focused in eukaryotes but not in bacteria. In this work, we identified and characterized a putative PAP type 2 (PAP2) encoded by the ro00075 gene in R. jostii RHA1. Heterologous expression of ro00075 in E. coli resulted in a fourfold increase in PAP activity and two-fold in DAG content. The conditional deletion of ro00075 in RHA1 led to a decrease in the content of DAG and TAG, whereas its overexpression in both RHA1 and R. opacus PD630 promoted an increase up to 10 to 15% by cellular dry weight in TAG content. On the other hand, expression of ro00075 in the non-oleaginous strain R. fascians F7 promoted an increase in total fatty acid content up to 7% at the expense of free fatty acids (FFA), DAG and TAG fractions. Moreover, co-expression of ro00075\/atf2 genes resulted in a fourfold increase in total fatty acid content by a further increase of the FFA and TAG fractions. The results of this study suggest that ro00075 encodes for a PAP2 enzyme actively involved in TAG biosynthesis. Overexpression of this gene, as single one or with an atf gene, provides an alternative approach to increase the biosynthesis and accumulation of bacterial oils as a potential source of raw material for biofuels production.","palabras_clave":"Rhodococcus|Triacylglycerols|PAP|Lipid metabolism|Biofuels"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17978,"idioma_id":4,"titulo":"Impairment of bony crypt development associated with hexavalent chromium exposure during tooth eruption.","resumen":"ABSTRACTImproperly treated hexavalent chromium-containing industrialwastes contaminate drinking water, potentially affectingchildren taking breast milk or baby bottles prepared with infantformula. Thus, the aim of the present work was to determine theeffect of this toxic on bone activity in the developing alveolusduring tooth eruption of suckling Wistar rats intoxicated withpotassium dichromate. Experimental animals received a dailydose of 12.5mg\/kg body weight of potassium dichromate bygavage for 10 days; controls received an equivalent volume ofsaline solution. Histologic and histomorphometric studiesof the mandible were performed. The data were statisticallyanalyzed using Student?s t test; statistical significance was setat a value of p tooth eruption, decreased periodontal width and bone volume,a lower percentage of bone formation surfaces, and higherpercentage of quiescent surfaces (pcontrols. The delay in tooth eruption observed after exposureto hexavalent chromium is the result of a lower rate of boneremodeling in the developing alveolus. The obtained resultsshow the importance of controlling toxic substances in drinkingwater, since their effects may alter the growth and developmentof subjects who were exposed during early infancy.","palabras_clave":"TOOTH ERUPTION|HEXAVALENT CHROMIUM|BONE REMODELING|DRINKING WATER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17979,"idioma_id":4,"titulo":"Semiclassical partition function for strings dual to Wilson loops with small cusps in ABJM","resumen":"We compute the 1-loop partition function for strings in AdS4×CP3, whose worldsheets end along a line with small cusp angles in the boundary of AdS. We obtain these 1-loop results in terms of the vacuum energy for on-shell modes. Our results verify the proposal by Lewkowycz and Maldacena in arXiv:1312.5682 for the exact Bremsstrahlung function up to the next to leading order in the strong coupling expansion. The agreement is observed for cusps distorting either the 1\/2 BPS or the 1\/6 BPS Wilson line","palabras_clave":"Wilson, ?t Hooft and Polyakov loops, , |AdS-CFT Correspondence|Strong Coupling Expansion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17980,"idioma_id":4,"titulo":"Cysteine modified polyaniline films improve biocompatibility for two cell lines","resumen":"This work focuses on one of the most exciting application areas of conjugated conducting polymers, which is cell culture and tissue engineering. To improve the biocompatibility of conducting polymers we present an easy method that involves the modification of the polymer backbone using l-cysteine. In this publication, we show the synthesis of polyaniline (PANI) films supported onto Polyethylene terephthalate (PET) films, and modified using cysteine (PANI-Cys) in order to generate a biocompatible substrate for cell culture. The PANI-Cys films are characterized by Fourier Transform infrared and UV?visible spectroscopy. The changes in the hydrophilicity of the polymer films after and before the modification were tested using contact angle measurements. After modification the contact angle changes from 86°&nbsp;±&nbsp;1 to 90°&nbsp;±&nbsp;1, suggesting a more hydrophylic surface. The adhesion properties of LM2 and HaCaT cell lines on the surface of PANI-Cys films in comparison with tissue culture plastic (TCP) are studied. The PANI-Cys film shows better biocompatibility than PANI film for both cell lines. The cell morphologies on the TCP and PANI-Cys film were examined by florescence and Atomic Force Microscopy (AFM). Microscopic observations show normal cellular behavior when PANI-Cys is used as a substrate of both cell lines (HaCaT and LM2) as when they are cultured on TCP. The ability of these PANI-Cys films to support cell attachment and growth indicates their potential use as biocompatible surfaces and in tissue engineering.","palabras_clave":"TISSUE EMGINEERING|CONDUCTING POLYMERS|POLYANILINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17981,"idioma_id":4,"titulo":"The optimum cut off value to differentiate Echinococcus granulosus sensu stricto from other species of E. granulosus sensu lato using larval rostellar hook morphometry","resumen":"Cystic echinococcosis caused by Echinococcus granulosus sensu lato is one of the most important helminth zoonoses in the world; it affects both humans and livestock. The disease is endemic in Argentina and highly endemic in the province of Neuquén. Considerable genetic and phenotypic variation has been demonstrated in E. granulosus, and 10 different genotypes (G1-G10) have been identified using molecular tools. E. granulosus sensu lato may be considered a species complex, comprised of E. granulosus sensu stricto (G1-G3), E. equinus (G4), E. ortleppi (G5) and E. canadensis (G6-G10). In endemic areas, the characterization of cystic echinococcosis molecular epidemiology is important in order to adequate the control strategies. A cut-off value for larval large hook total length to distinguish E. granulosus sensu stricto isolates from those produced by other species of the complex was defined for the first time. Overall, 1780 larval hooks of 36 isolates obtained from sheep (n=11, G1), goats (n=10, G6), cattle (n=5, G6) and pigs (n=10, G7) were analyzed. Validation against molecular genotyping as gold standard was carried out using the Receiver Operating Characteristic (ROC) curve analysis. The optimal cut-off value was defined as 26.5 µm. The proposed method showed high sensitivity (97.8%) and specificity (91.1%). Since in most endemic regions the molecular epidemiology of echinococcosis includes the coexistence of the widely distributed E. granulosus sensu stricto G1 strain and other species of the complex, this technique could be useful as a quick and economical tool for epidemiological and surveillance field studies, when fertile cysts are present.","palabras_clave":"Echinococcus granulosus|Rostellar hook|Morphometry|Genotypes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17982,"idioma_id":4,"titulo":"Choosing Ayurveda as a health care practice in Argentina","resumen":"In this article we analyze the process of adoption of Ayurveda as a healthcare practice in Buenos Aires, focusing on sociocultural dimensions and material aspects which either facilitate or discourage the following of this foreign medical tradition. Ayurveda is an ancient Indian medicine whose popularity has been on the rise among the Argentinean middle and upper classes. Introduced as a ?lifestyle? medicine, it resonates with the new health consciousness of individual responsibility in health maintenance and improvement. Based on in-depth interviews conducted with 20 followers of Ayurveda in Buenos Aires, we show that it attracts New Agers, adherents to food-driven subcultures, and patients dissatisfied with the limitations of biomedicine. Followers develop new skills for self-understanding, self-healing, and wellbeing. As adherents to a foreign medical approach, however, they adopt Ayurvedic practices in flexible ways, and some even hold critical views on the elitist market niches of Ayurvedic specialists and products.","palabras_clave":"COMPLEMENTARY AND ALTERNATIVE MEDICINE|AYURVEDA|HEALTHCARE|CHOICE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17983,"idioma_id":5,"titulo":"El reconocimiento judicial del derecho humano de acceso al agua potable en Argentina. Reflexiones a raíz del dictado del fallo Kersich Juan Gabriel en la Corte Suprema de Justicia de la Nación","resumen":"El derecho humano al agua es el derecho de todos de disponer de agua suficiente, salubre, aceptable y asequible para el uso personal y doméstico.  La disponibilidad del agua supone un abastecimiento continuo y suficiente para los usos personales y domésticos (pto. 12.a, Observación General 15). Entre ellos, quedan comprendidos el consumo por boca, el lavado de la ropa, la preparación de alimentos y la higiene personal y del hogar. El agua debe ser salubre, esto es, exenta de microbios y de sustancias químicas y radiológicas. Debe poseer un color, un olor y un sabor aceptables. Su abastecimiento debe ser accesible a todos. Es decir, debe encontrase al alcance tanto físico como económico de la población.  Por su parte, en el ámbito internacional, el 28\/7\/2010, en el 64º período de sesiones, en el tema 48 del programa Aplicación y seguimiento integrados y coordinados de los resultados de las grandes conferencias y cumbres de las Naciones Unidas en las esferas económica y social y esferas conexas, la Asamblea General de las Naciones Unidas adoptó una resolución de notable relevancia. El 30\/9\/2010, el Consejo de Derechos Humanos de las Naciones Unidas reconoció en forma explícita y ratificó que el acceso al agua potable y al saneamiento por parte de cualquier persona constituye un derecho humano fundamental. Estos instrumentos internacionales históricos declaran el derecho al acceso al agua potable y al saneamiento como un derecho humano esencial para el pleno disfrute de la vida y de todos los derechos humanos. Es la primera vez que un organismo internacional trató con esta intensidad algún aspecto perteneciente a la esfera ambiental, materializándose a través del dictado de dos instrumentos en tan breve lapso de tiempo.","palabras_clave":"DERECHO|HUMANO|AGUA|CORTE|SUPREMA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17984,"idioma_id":4,"titulo":"QSPR analysis for the retention index of flavors and fragrances on a OV-101 column","resumen":"A predictive quantitative structure?property relationships (QSPR) is developed for modeling the retention indexmeasured on the OV-101 glass capillary gas chromatography column, in a set of 1208 flavor and fragrance com-pounds. The 4885 molecular descriptors are calculated using the Dragon software and then are simultaneouslyanalyzed through multivariable linear regression analysis using the replacement method (RM) variable subsetselection technique. We proceed in three steps, the first one by considering all descriptor blocks, the secondone by excluding conformational descriptors blocks, and the last one by analyzing only 3D-descriptors families.The models are properly validated through an external test set of compounds. Cross-validation methods such asleave-one-out and leave-more-out are applied, together with Y-randomization and applicability domain analysis.The results clearly suggest that 3D-descriptors do not offer relevant information for modeling the retentionindex, while a topological index such as the solvation connectivity index of first order has a high relevance forthis purpose.","palabras_clave":"-"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17985,"idioma_id":4,"titulo":"Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia","resumen":"Continuous environmental stimulation induced by exposure to enriched environment (EE) has yielded cognitive benefits in different models of brain injury. Perinatal asphyxia results from a lack of oxygen supply to the fetus and is associated with long-lasting neurological deficits. However, the effects of EE in middle-aged rats suffering perinatal asphyxia are unknown. Therefore, the aim of the present study was to assess whether life-long exposure to EE could counteract the cognitive and behavioral alterations in middle-aged asphyctic rats. Experimental groups consisted of rats born vaginally (CTL), by cesarean section (C+), or by C+ following 19 min of asphyxia at birth (PA). At weaning, rats were assigned to standard (SE) or enriched environment (EE) for 18 months. During the last month of housing, animals were submitted to a behavioral test battery including Elevated Plus Maze, Open Field, Novel Object Recognition and Morris water maze (MWM). Results showed that middle-aged asphyctic rats, reared in SE, exhibited an impaired performance in the spatial reference and working memory versions of the MWM. EE was able to counteract these cognitive impairments. Moreover, EE improved the spatial learning performance of middle-aged CTL and C+ rats. On the other hand, all groups reared in SE did not differ in locomotor activity and anxiety levels, while EE reduced locomotion and anxiety, regardless of birth condition. Recognition memory was altered neither by birth condition nor by housing environment. These results support the importance of environmental stimulation across the lifespan to prevent cognitive deficits induced by perinatal asphyxia","palabras_clave":"PERINATAL ASPHYXIA|ENVIRONMENTAL ENRICHMENT|AGING|HABITUATION|ANXIETY|RECOGNITION MEMORY|SPATIAL|REFERENCE MEMORY|SPATIAL WORKING MEMORY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17986,"idioma_id":4,"titulo":"Measuring Individual Differences in Driver Inattention: Further Validation of the Attention-Related Driving Errors Scale","resumen":"Objective: The aim of this research was (a) to study driver inattention as a trait-like variable and (b) to provide new evidence of validity for the Attention-Related Driving Errors Scale (ARDES).Background: Driving inattention is approached from an individual differences perspective. We are interested in how drivers vary in their propensity to experience failures of attention and in the methods to measure these differences. Method: In a first sample (n = 301), we tested, via confirmatory factor analysis, a new theoretical model for the ARDES. In a second sample (n = 201), we evaluated therelationship between inattention and internal and external sources of distraction and social desirability bias in ARDES responses. A subsample (n = 65) was reevaluated to study temporal stability of the ARDES scores.Results: Errors measured by the ARDES can be classified according to the driving task level at which they occur (navigation, maneuvering, or control). Differences inARDES scores based on collision history were observed. ARDES was related to internal sources of distraction and was independent of the level of exposure to distractingactivities. Test-retest showed a high degree of stability in ARDES scores. Low correlations were found with a social desirability measure.Conclusion: ARDES appears to measure a personal trait that remains relatively stable over time and is relatively independent of distracting activities. New evidenceof validity emerged for this self-report.Application: ARDES can be used to measure individual differences in driving inattention and to help tailor preventive interventions for inattentive drivers. It can serve as an instrument of driver self-assessment in educational and training contexts.","palabras_clave":"ROAD SAFETY|DRIVER INATTENTION|MEASUREMENT|SOCIAL DESIRABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17987,"idioma_id":5,"titulo":"Evolución de las competencias científicas en las carreras de Bioquímica y Biotecnología de la Universidad Nacional del Litoral, Argentina. Un estudio longitudinal","resumen":"Este estudio está fundamentado en el marco de las pruebas PISA 2006 (OCDE, 2008), sobre competencia científica. En la presente tesis se indagó en qué medida una muestra de alumnos de las carreras de Bioquímica y Biotecnología de la Universidad Nacional del Litoral (Argentina) adquieren y\/o desarrollan dicha competencia durante los tres primeros años del nivel universitario (ciclo básico).","palabras_clave":"Competencias científicas|Educación superior|Conocimiento científico"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17988,"idioma_id":5,"titulo":"Implementación de un filtro adaptivo utilizando una estrategia de hardware evolutivo","resumen":"This paper explores the feasibility of an adaptive scheme to tolerate degradations in a high- order low- pass filter, taken as a case study. The adaptation is achieved through an evolvable hardware strategy that employs reconfigurable hardware and a genetic algorithm (GA). For establishing the filter reconfiguration, it is considered that it is tested periodically during in-field operation using Transient Analysis Method (TRAM). If TRAM founds that the filter does not fulfill the specifications, then the AG, which runs on an external computer, searches a new set of configurable parameters that allows the filter reaching the specifications. Then, the hardware is configured with these new parameters for continuing its normal operation. For the proposed scheme, simulation results show the TRAM feasibility when certain restrictions are taken for its implementation. The AG evaluation is performed through fault simulation, using four fault models that consider deviations in circuital parameters. The results show that AG founds, in all fault conditions simulated, solutions with errors smaller than the tolerable ones, demonstrating the feasibility of the proposed scheme.","palabras_clave":"adaptive filter|evolvable hardware|genetic algorithms|multiobjective optimization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17989,"idioma_id":5,"titulo":"Revelación de información voluntaria sobre Capital Intelectual: factores explicativos en empresas cotizantes argentinas","resumen":"Preocupados en poder identificar aquellas características propias de las empresas que pueden resultar significativas para explicar la política de revelación de información voluntaria sobre los Activos Intangibles incorporados en los componentes del Capital Intelectual, es que se ha realizado un estudio de tipo correlacional que apunta a analizar la relación entre ciertas características de las empresas cotizantes en el Mercado de Valores de Buenos Aires y un índice que recoge la información que voluntariamente revelan estas empresas sobre los componentes de dichos elementos intangibles. El análisis de regresión múltiple aplicado indica que son las empresas con altos niveles de endeudamiento las que parecen estar más predispuestas a brindar información adicional sobre los componentes del capital intelectual, en tanto que las más rentables parecen oponerse a este tipo de revelación.","palabras_clave":"INFORMACION VOLUNTARIA|CAPITAL INTELECTUAL|CARACTERÍSTICAS EMPRESARIALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17990,"idioma_id":5,"titulo":"Interpretación del lenguaje simbólico de la física: las lecturas de los estudiantes","resumen":"Los recursos formales ¬-matemáticos y lógicos- son fundamentales en el análisis y la descripción de la naturaleza, pero su uso exige considerar las diferencias sustanciales entre enunciados formales y fácticos. En este trabajo nos proponemos reflexionar sobre la dificultad que representa, para los estudiantes, la comprensión y el manejo de lenguaje de la física. Analizaremos algunas limitaciones detectadas en estudiantes de los primeros cursos de física universitaria, vinculadas a la interpretación del lenguaje simbólico empleado al formalizar los enunciados de la disciplina. Sugeriremos algunas implicancias para la enseñanza. Entendemos que no sólo la complejidad propia de un nuevo lenguaje y su formalización, sino también la desvinculación con la que se suele presentar la dupla concepto-formalización del mismo, generan dificultades para los alumnos. Esta dificultad se suma a otra relacionada con la imposibilidad de utilizar de manera apropiada en las clases de física términos del lenguaje natural, utilizados también en el lenguaje de la física, pero con distinto significado y referencia. Sostendremos que los vínculos entre el lenguaje técnico que utiliza la física, las estructuras matemáticas y los esquemas experimentales, sirven para describir, explicar y definir su objeto de estudio, el mundo al que se refiere y las herramientas a través de las cuales lo aborda. Por ello, consideramos que estableciendo de manera clara dichos vínculos, acercaremos a los estudiantes (y docentes) a una mejor comprensión de los modelos y teorías así como a una mejor interpretación de las definiciones y leyes de la física y las diferencias sustanciales entre ellas.","palabras_clave":"LENGUAJE|FISICA|SIGNIFICADO|ENUNCIADOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17991,"idioma_id":4,"titulo":"Hematological values of three Antarctic penguins: Gentoo (Pygoscelis papua), Adélie (P. adeliae) and Chinstrap (P. antarcticus)","resumen":"It is established that haematological and biochemical parameters provide important data to assess the physiological condition and health status of wild  birds. To undertake conservation physiology or ecophysiology work, it is  therefore essential to establish baseline physiological parameters and how  these parameters change with age and life history events. In this work, we  determined and compared baseline haematology and serum biochemistry  between adults and chicks of three Antarctic penguin species of the genus  Pygoscelis: gentoo (P. papua), Ade´ lie (P. adeliae) and chinstrap (P. antarcticus).  Differences in adults among species were observed in haemoglobin and  biochemical parameters such as total proteins, glucose and alkaline phosphatase  activity. In addition, differences between adults and chicks in haematocrit,  haemoglobin, total proteins and glucose concentration were determined.  Moreover, we evaluated the electrophoretic protein profiles between adults  and chicks of the genus Pygoscelis, and a conserved protein pattern was  observed among species and ages in the genus. Altogether, the results suggest  that biochemical and haematological differences among pygoscelids may be  related to the nutritional status and energetic expenditure during breeding as  well as their feeding habits and development stage.  Citation: Polar Research 2015, 34, 25718, http:\/\/dx.doi.org\/10.3402\/polar.v34.25718","palabras_clave":"Hematological|Antarctic penguins"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17992,"idioma_id":4,"titulo":"Improved antibacterial activity of Cu using heteropolyacid with different precursors by sol-gel: synthesis and characterization","resumen":"Antimicrobial coatings are used to avoid the  proliferation of fungi and bacteria inside urban buildings  by incorporating low concentrations of antimicrobial  agents (biocides). This study is focused on evaluating the  antifungal activity of copper (II) supported on a silica  matrix, and as counter-cation of a heteropolyacid, obtained  from the sol?gel method using various catalysts, against  two fungal isolates. The fungi used in this evaluation were  Alternaria alternata and Chaetomium globosum isolated by  routine microbiological techniques from biodeteriorated  paints films. In all cases, fungi were selected due to their  ability to grow on the paint films and their negative impact  on human health. First, silicas were prepared using tetraethylorthosilicate  and methyl trimethoxysilane as precursors  and acetic acid, hydrochloric acid as catalysts of  the hydrolysis reaction of the alkoxide. The effect of addition  of copper (II) in the form of copper nitrate was  studied. With respect to the morphology of the silica, most  of them are similar, between pure and modified silica, in all  cases.","palabras_clave":"BIOCIDE|SILICA|ANTIFÚNGAL|SOL-GEL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17993,"idioma_id":4,"titulo":"Synthesis and characterization of zirconium oxides for use as antimicrobial additives in paints","resumen":"Zirconia is a widely used multifunctional material. Its interesting properties, such as high chemical resistance, thermal stabilityand high mechanical toughness, have turned this material into object of study within fields such as optics, electronics, andmagnetism, among others. In recent years, the chemical properties of zirconium oxide have been used, mixed with silicon, inorder to obtain more stable and robust mixed oxides, with the final application of toughening ceramics. These properties arerelated to the degree of mixing of the components at molecular level, therefore, the linking between Si-O-Zr. Considering theeffective antimicrobial capacity of silver nanoparticles, their incorporation into different materials is very interesting, acting asbiocides. The objective of this work is to obtain zirconium oxides by the sol-gel technique, using zirconium n-propoxide asprecursor, and also to study the effect of different solvents (water, ethanol) and the use of various acid catalysts in the synthesis[acetic acid and a heteropolyacid (HPA), as the phosphomolybdic acid (H3PMo12O40)] on the physicochemical properties of theobtained solids. Finally, the addition of a silver salt was carried out into the sample with acetic acid and heteropolyacid ascatalyst, in order to incorporate it as antimicrobial filler in paints. The obtained materials were characterized by SEM, XRD, FTIR,textural properties through the absorption of N2 (SBET) and potentiometric titration with n-butylamine. Homogeneous solidswere obtained in all the synthesis with acetic acid as catalysts. In addition, x-ray diffraction diagrams of amorphous solids wereobserved. The values obtained of surface areas are influenced by the variables of synthesis. The characteristic bands of zirconiawere observed by FTIR in the solids synthesized. The results show that the solids environmentally synthesized are promisingadditives for use in paints.","palabras_clave":"BIOCIDAS|ADITIVOS|ANTIMICROBIANOS|RECUBRIMIENTOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17995,"idioma_id":5,"titulo":"Percepción de la gravedad del cuadro clínico como determinante de automedicación   entre estudiantes universitarios","resumen":"Introducción: La automedicación ha sido una estrategia frecuentemente utilizada como respuesta a una situación de malestar o enfermedad, ha jugado y juega un rol importante como primer eslabón en la atención de la salud, aunque no se la reconoce como tal. Se trazó como objetivo analizar la automedicación desde la perspectiva de los propios actores sociales Material y método: Investigación de metodología cualitativa entre estudiantes universitarios de la Facultad de Medicina de la Universidad Nacional del Nordeste de Corrientes, Argentina,   durante el ciclo lectivo 2013. Se utilizó el Método Comparativo Constante de Glaser y Strauss. Los datos fueron recolectados a través de entrevistas semiestructuradas, en profundidad. Se procedió a un análisis en espiral, arribándose a la generación de categorías respaldadas por fragmentos textuales de las entrevistas.  Resultados: Los estudiantes universitarios se sienten seguros y capaces de automedicarse ante cuadros clínicos que les resulta de baja complejidad y los previamente vivenciados por ellos o por familiares y conocidos.  Discusión: El sentirse enfermo es una vivencia inseparable de la personalidad y de la biografía de cada sujeto. La respuesta a esa enfermedad es un saber heredado de la historia epigénica o formativa que ha sido olvidada tras su caída en la inmediatez.","palabras_clave":"Autocuidado|Significación|Historia Formativa|Estudiantes Universitarios"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17996,"idioma_id":5,"titulo":"LOCALIZACION DE PLANTA DE TRATAMIENTO DE AGUA APLICANDO TÉCNICAS DE OPTIMIZACIÓN","resumen":"Se presenta un estudio realizado para encontrar la mejor ubicación de la planta de tratamiento de agua en Misión Nueva Pompeya, en el Impenetrable Chaqueño, de manera tal de minimizar los impactos negativos provocados por su construcción y operación.   Para ello se formuló un modelo de apoyo  a la decisión basado en una técnica de optimización multiobjetivo, incorporando una variante de ?relajamiento difuso?.  Se tuvieron en cuenta aspectos relevantes, como riesgo sanitario, molestias a la población, costos, además de otros de naturaleza técnica.   El abordaje que se presenta en este trabajo buscó minimizar las valoraciones subjetivas que se dan en procesos de selección de alternativas.","palabras_clave":"MINIMIZACIÓN DE IMPACTOS|OPTIMIZACIÓN MULTIOBJETIVO|RELAJAMIENTO DIFUSO|AGUA POTABLE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17997,"idioma_id":4,"titulo":"Energy allocation to growth and reproduction in a viviparous lizard endemic to the Highlands of the Andes, Argentina","resumen":"Individuals devote energy intake to growth, maintenance and reproduction, so knowing the way in which they allocate this energy between competing demands is essential to understand their relationship with the environment. Phymaturus lizards, viviparous and mostly herbivorous, inhabit cold environments of the Andes highlands of Argentina and Chile, and the volcanic plateaus of Patagonia, Argentina. Herein we discussed the interplay between reproductive effort and growth in Phymaturus punae, a lizard with a biannual female reproductive cycle and the lowest annual reproductive output of the genus. Using skeletochronology, we estimated that juveniles reach up to 7-8 years, and that adults have 8-18 years in females and 9-20 years in males. Juveniles grow faster than adults, and adult females have higher specific growth rates than adult males. The adult life span was 10 years for females and 11 for males, and the relative reproductive time was 1.25 for females and 1.22 for males. Net reproductive rate resulted in 7.5 offspring throughout the females? reproductive life. During adulthood a negative correlation between the ring width and age was found in males, while in females the ring width showed a pattern related with the yearly reproductive state. Females tend to have wider rings when pregnant and narrower rings when vitellogenic. The intersexual differential investment in growth is congruent with different requirements for reproduction between genders, whereas the tendency of females to grow less during vitellogenesis than during pregnancy, suggests differences in the metabolic costs of these reproductive processes. Even when P. punae exhibits high life span, females have a relative low lifetime reproductive effort and net reproductive rate. However, this still represents a high reproductive investment for this species, considering the harsh conditions of the environments where it lives, the viviparous reproductive mode, and their herbivorous diet.","palabras_clave":"Phymaturus punae;  |harsh environments; |energy allocation;|skeletochronology; reproductive effort; viviparity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17998,"idioma_id":4,"titulo":"Glycerol dehydration catalyzed by MWW zeolites and the changes inthe catalyst deactivation caused by porosity modification","resumen":"tMembers of the layered MWW family, including microporous MCM-22, pillared MCM-36 anddelaminated ITQ-2 zeolites, were used as catalysts for the gas phase dehydration of glycerol. Thechemical, structural and surface properties of the catalysts were characterized by X-ray diffraction,N2adsorption?desorption isotherms, SEM, TEM, NH3-TPD and pyridine chemisorption followed by IRspectroscopy. The results clearly showed that the modified zeolites with designed mesopore structureenabled rapid diffusion and consequently improved the glycerol conversion. Characterization of the acidsites revealed that the relative abundance of Brønsted and Lewis acid sites influenced the efficiency of thecatalysis performed by these materials.13C NMR spectra of the spent catalysts confirmed that differencesin the nature and amount of carbonaceous deposits are related to the pore structures of the catalysts, withgreater formation of polyaromatic compounds inside zeolite pores, while polyglycols are preferentiallyformed at the external surfaces of the MCM-36 and ITQ-2 zeolites, as expected for the more exposedsheets.","palabras_clave":"MWW ZEOLITES|GLYCEROL DEHYDRATION|DEACTIVATION|PILLARIZATION|DELAMINATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":17999,"idioma_id":4,"titulo":"Striking properties of light transmitted by a double period nanoslit structure under evanescent incidence","resumen":"The excitation of phase resonances in dual-period wire structures under evanescent incidence is investigated and numerically reported for the first time. The diffraction problem of a compound structure comprising subwavelength perfectly conducting wires and slits near a dielectric interface is solved by the modal method, which has been extended to consider evanescent incidence via illumination under the total internal reflection condition. We demonstrate evanescent-to-propagating conversion in the transmitted intensity via resonances of different types, such as Fabry?Perot and Rayleigh anomalies. The results exhibit points in common with those obtained for simple structures (single wire\/slit per period), but, on the other hand, there are striking differences, mainly arising from the excitation of phase resonances in the structure. These features allow an angular and spectral control of the transmitted response, which opens up new degrees of freedom for the design of input\/output couplers and other devices.","palabras_clave":"ENHANCED TRANSMISSION|SUBWAVELENGTH SLITS|DUAL-PERIOD STRUCTURES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18000,"idioma_id":4,"titulo":"Development of an ionic liquid based-dispersive liquid?liquid microextraction method for the determination of antichagasic drugs in human breast milk. Optimization by central composite design","resumen":"Chagas disease constitutes a major public health problem in Latin America. Human breast milk is a biological sample of great importance for the analysis of therapeutic drugs, as unwanted exposure through breast milk could result in pharmacological effects in the nursing infant. Thus, the goal of breast milk drug analysis is to inquire to which extent a neonate may be exposed to a drug during lactation. In this work, we developed an analytical technique to quantify benznidazole and nifurtimox (the two antichagasic drugs currently available for the medical treatment) in human breast milk, with a simple sample pre-treatment followed by an ionic-liquid-based dispersive liquid?liquid microextraction combined with high-performance liquid chromatography and UV detection. For this technique, the ionic liquid 1-octyl-3-methylimidazolium hexafluorophosphate has been used as the ?extraction solvent?. A central composite design was used to find the optimum values for the significant variables affecting the extraction process: volume of ionic liquid, volume of dispersant solvent, ionic strength, and pH. At the optimum working conditions, the average recoveries were 77.5 and 89.7%, the limits of detection were 0.06 and 0.09 &#956;g mL&#8722;1 and the inter-day reproducibilities were 6.25 and 5.77% for benznidazole and nifurtimox, respectively. The proposed methodology can be considered sensitive, simple, robust, accurate, and green.","palabras_clave":"BENZNIDAZOLE,|NIFURTIMOX |DISPERSIVE LIQUIDLIQUID MICROEXTRACTION|LIQUID CHROMATOGRAPHY|IONIC LIQUIDS|CENTRAL COMPOSITE DESIGN."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18001,"idioma_id":4,"titulo":"Aluminum as catalyst for ZnO nanostructures growth","resumen":"tWe report the growth of Al-catalyzed ZnO nanowires (NWs) using a thermal evaporation technique.Before the growth, the substrates were covered with a distribution of Al nano-island that act as seeds.We found that the density of NWs increases as the density of seeds is increased, confirming the cat-alyst properties of Al. The critical parameters of growth are the substrate temperature, oxygen partialpressure and the thickness of the initial Al layer from which the seeds are formed. The results showedthat the oxygen pressure has a strong influence on the structural characteristics: the nanowires exhibit apreferential orientation in the (0 0 l)-planes when they are grown at low oxygen flow, and they becomepolycrystalline when a high concentration of oxygen in the flow is used. We consider that the growthoccurs via a vapor-solid-solid (VSS) process as the predominant growth mechanism","palabras_clave":"NANOWIRES|CATALYST|ZNO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18002,"idioma_id":4,"titulo":"Comparative and evolutionary analyses of Meloidogyne spp. based on mitochondrial genome sequences","resumen":"Molecular taxonomy and evolution of nematodes have been recently the focus of several studies. Mitochondrial sequences were proposed as an alternative for precise identification of Meloidogyne species, to study intraspecific variability and to follow maternal lineages. We characterized the mitochondrial genomes (mtDNAs) of the root knot nematodes M. floridensis, M. hapla and M. incognita. These were AT rich (81?83%) and highly compact, encoding 12 proteins, 2 rRNAs, and 22 tRNAs. Comparisons with published mtDNAs of M. chitwoodi, M. incognita (another strain) and M. graminicola revealed that they share protein and rRNA  gene order but differ in the order of tRNAs. The mtDNAs of M. floridensis and M. incognita were strikingly similar (97?100% identity for all coding regions). In contrast, M. floridensis,  M. chitwoodi, M. hapla and M. graminicola showed 65?84% nucleotide identity for coding regions. Variable mitochondrial sequences are potentially useful for evolutionary and taxonomic studies. We developed a molecular taxonomic marker by sequencing a highly-variable ~2 kb mitochondrial region, nad5-cox1, from 36 populations of root-knot nematodes to elucidate relationships within the genus Meloidogyne. Isolates of five species formed monophyletic groups and showed little intraspecific variability. We also present a thorough analysis of  the mitochondrial region cox2-rrnS. Phylogenies based on either mitochondrial region had good discrimination power but could not discriminate between M. arenaria, M. incognita and  M. floridensis.","palabras_clave":"Meloidogyne|Mitochondrial DNA|phylogeny|taxonomy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18003,"idioma_id":5,"titulo":"Políticas públicas y estrategias para el desarrollo de la investigación en las universidades privadas argentinas","resumen":"El objetivo de este artículo es analizar en qué medida las políticas de aseguramiento de la calidad y el financiamiento gubernamental para la investigación impulsaron cambios en dicha función en las universidades privadas de la Argentina. Partiendo del enfoque organizacional aplicado al estudio del cambio universitario, se llevó a cabo un estudio de casos. Para identificar el proceso de cambio se construyeron indicadores cuantitativos de I+D, se estudió la significatividad estadística de la diferencia de éstos entre períodos y se aplicó un análisis de conglomerados. Asimismo, se estudió la influencia de las políticas públicas sobre estos cambios a partir del análisis de documentos oficiales e institucionales y de entrevistas en profundidad a informantes claves y autoridades de las universidades. En los resultados alcanzados se observa una tensión en las respuestas organizacionales entre impulsar cambios isomórficos, para lograr conformidad y legitimación en su medio, y desarrollar estrategias acordes con su misión institucional, los recursos organizacionales y los liderazgos particulares presentes en cada caso. Los resultados muestran que las políticas públicas han sido efectivas en darle cierto impulso a la actividad de investigación en las universidades que previamente presentaban un desarrollo incipiente y en la consolidación progresiva, en las que ya tenían una misión institucional alineada con el modelo de universidad de investigación.","palabras_clave":"POLÍTICAS PÚBLICAS|ASEGURAMIENTO DE LA CALIDAD|FINANCIAMIENTO E INVESTIGACIÓN|UNIVERSIDADES PRIVADAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18004,"idioma_id":4,"titulo":"Mild degradation processes in ZnO-based varistors: the role of Zn vacancies","resumen":"The effects of a degradation process on the structural and electrical properties of ZnO-based varistors induced by the application of dc bias voltage were analysed. Capacitance and resistance measurements were carried out to electrically characterize the polycrystalline semiconductor before and after different degrees of mild degradation. Vacancies? changes in the varistors were studied with positron annihilation lifetime spectroscopy. Variations on the potential barrier height and effective doping concentration were determined by fitting the experimental data from impedance spectroscopy measurements. These results indicate two different stages in the degradation process consistent with vacancy-like concentration changes.","palabras_clave":"zinc oxide|varistors|degradation|impedance spectroscopy|positron annihilation lifetime spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18005,"idioma_id":4,"titulo":"Growth, survival and bone alterations in Piaractus mesopotamicus larvae under different rearing protocols","resumen":"The pacu (Piaractus mesopotamicus) is a neotropical freshwater fish. It is one of the most important species farmed in areas of the Parana and Paraguay Rivers basins. The effects of different rearing protocols on growth, survival and incidence of skeletal malformations in pacu larvae were analyzed. A total of six experimental treatments were considered, consisting of: a semi-intensive larviculture (LS) in ponds; intensive larviculture (LIn) in laboratory (both LS and LIn until 60 days of life); and mixed larviculture, with 20 days of semi-intensive larviculture into cages in ponds after 14 (L1), 21 (L2), 33 (L3) or 40 (L4) days of laboratory larviculture. At the end of the experimental period, LS larvae showed higher growth rate, with average weight values (2.28 g) and total length (TL-48.20 mm) statistically higher than the rest (p0.05), while LIn presented the lowest growth (p<0.05). Survival was around 75% in all experimental groups, except LS, that presented a significantly lower value (17.5%, p<0.05). Skeletal abnormalities were detected in all experimental treatments, but LIn and L1 presented the lowest incidence. In no case, visible morphological alterations were found. This study shows that prolonging pacu rearing under laboratory conditions at high densities improves temporal availability and survival of juvenile without affecting growth or subsequent osteological development of fish.","palabras_clave":"LARVICULTURE|PIARACTUS MESOPOTAMICUS|BONE MALFORMATIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18006,"idioma_id":4,"titulo":"First record of Ophrydium versatile (Muller, 1786) Ehrenberg, 1838 (Protista: Peritrichida: Ophrydiidae) from the High Paraná River influence area (Misiones, Province, Argentina).","resumen":"Ophrydium versatile, a green protozoon that form sessile colonies is reported for the first time for the Misiones Province, Argentina from shallow waters of a recently formed pond in the Garupá Stream floodplain, at about 900 meters away from the confluence with the High Paraná River. To our knowledge this constitutes the second and northernmost record of the species for Argentina and the first for a subtropical environment in the country.","palabras_clave":"FRESWATER PROTOZOON |SYMBIOTIC CILIATE|NEW REPORT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18007,"idioma_id":4,"titulo":"The Hungaria population: A comparison between sub-groups","resumen":"To investigate if the two sub-groups in proper inclination found in the Hungaria region by Milani et al.(2010) could be characterized by physical parameters of the objects, we analyze two surfaces propertiesof the asteroids in the zone: the taxonomical distribution, obtained from the SDSS-MOC4, and the albedodistribution, taken from the WISE data. Our analysis suggests that both sub-groups are different.The asteroids with sin ip o 0:4 exhibit a majority of X-types objects and an excess of high albedo objects.In contrast, the objects with sin ip 4 0:4 show a taxonomical distribution dominated by S-types asteroidsand an albedo distribution without high albedo excess. Based on these results we propose that the sub-group in high proper inclination and dominated by S-types could be the primordial population while thehigh albedo excess observed in the other sub-group could be the consequence of a contamination in thisregion with a medium-belt object(s) that filled the Hungaria region with fresh X-types after suffering a&nbsp;catastrophic collision.","palabras_clave":"SOLAR SYSTEM|ASTEROIDS|ALBEDO|TAXONOMY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18008,"idioma_id":4,"titulo":"Continuous assessment of carotid intima-media thickness applied to estimate a volumetric compliance using B-mode ultrasound sequences","resumen":"Recent reports have shown that the carotid artery wall had significant movements not only in the radial but also in the longitudinal direction during the cardiac cycle. Accordingly, the idea that longitudinal elongations could be systematically neglected for compliance estimations became controversial. Assuming a dynamic change in vessel length, the standard measurement of cross-sectional compliance can be revised. In this work, we propose to estimate a volumetric compliance based on continuous measurements of carotid diameter and intima-media thickness (IMT) from B-mode ultrasound sequences. Assuming the principle of conservation of the mass of wall volume (compressibility equals zero), a temporal longitudinal elongation can be calculated to estimate a volumetric compliance. Moreover, elongations can also be estimated allowing small compressibility factors to model some wall leakage. The cross-sectional and the volumetric compliance were estimated in 45 healthy volunteers and 19 asymptomatic patients. The standard measurement underestimated the volumetric compliance by 25% for young volunteers (p&nbsp;&lt;&nbsp;0.01) and 17% for patients (p&nbsp;&lt;&nbsp;0.05). When compressibility factors different from zero were allowed, volunteers and patients reached values of 9% and 4%, respectively. We conclude that a simultaneous assessment of carotid diameter and IMT can be employed to estimate a volumetric compliance incorporating a longitudinal elongation. The cross-sectional compliance, that neglects the change in vessel length, underestimates the volumetric compliance","palabras_clave":"cross-sectional compliance|carotid artery|compressibility,"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18009,"idioma_id":4,"titulo":"A new minicurd model system for hard cooked cheeses","resumen":"A new minicurd model of hard cheese was proposed and validated. For that, curd particles and whey obtained from conventional cheese-making of Reggianito Argentino were separated and frozen. After that, both fractions were thawed and the mixture whey-curds was reconstituted, from which minicurds were made at laboratory scale. Repeatability, and the effect of freezing on the minicurd composition were investigated by assessing pH, proteins, moisture content, sodium chloride and total thermophilic lactic flora counts. Good repeatability was achieved, and no significant differences were found between minicurds made from fresh and frozen materials. Composition of the minicurd was appropriate to model Reggianito Argentino cheese.","palabras_clave":"minicurd model |hard cheese|cheese making technology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18010,"idioma_id":4,"titulo":"'Arsenic sorption onto titanium dioxide, granular ferric hydroxide and activated alumina: Batch and dynamic studies'","resumen":"                                                                The  aim of this work was to evaluate and compare the efficiencies of three  different adsorbents for arsenic (As) removal from water: titanium dioxide (TiO2),  granular ferric hydroxide (GFH) and activated alumina (AA). Equilibrium  experiments for dissolved arsenite and arsenate were carried out through batch  tests. Freundlich and Langmuir isotherm models were adopted and their  parameters were estimated by nonlinear regressions. In addition, dynamic  experiments were performed in mini fixed bed columns and breakthrough curves  were obtained for each combination of sorbate\/adsorbent. Experimental results obtained  by column assays were compared with predictions of well-known breakthrough models  (Bohart-Adams and Clark). Results indicate that As(V) is more easily adsorbed  than As(III) for AA and GFH while TiO2 has a similar behavior for  both species. The titanium based material is the most efficient adsorbent to  carry out the process, followed by the GFH.                        ","palabras_clave":"Adsorption column|Adsorption isotherm|Arsenic removal|Breakthrough curves"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18011,"idioma_id":4,"titulo":"Efficacy of a trans-sialidase-ISCOMATRIX subunit vaccine candidate to protect against experimental Chagas disease","resumen":"Recombinant protein vaccines are safe but elicit low immunological responses. The new generation of adjuvants is currently reversing this situation. Here, a new antigen-adjuvant combination for protection against experimental Chagas disease was assessed. The antigen used in the formulation was a glycosylated mutant inactive trans-sialidase (mTS) that was previously proven to be highly protective against Trypanosoma cruzi infection; here, we show that it can be produced in large quantities and high quality using Pichia pastoris. The adjuvant used in the formulation was ISCOMATRIX (IMX), which was found to be effective and safe in human clinical trials of vaccines designed to control other intracellular infections. Fifteen days after the third immunization, mice immunized with mTS-IMX showed a TS-specific IgG response with titers >10(6) and high avidity, an increased IgG2a\/IgG1 ratio, significant delayed-type hypersensitivity (DTH) reactivity, a balanced production of IFN-&#947; and IL-10 by splenocytes and a strong IFN-&#947; secretion by CD8(+) T lymphocytes. When these mice where challenged with 1000 trypomastigotes of T. cruzi, all mTS-IMX immunized mice survived, whereas mice immunized with mTS alone, IMX or PBS exhibited high mortality. Remarkably, during acute infection, when the parasitemia is highest in this infection model (day 21), mTS-IMX immunized mice had &#8764;50 times less parasitemia than non-immunized mice. At this moment and also in the chronic phase, 100 days after infection, tissue presented &#8764;4.5 times lower parasite load and associated inflammatory infiltrate and lesions. These results indicate that protection against Chagas disease can be achieved by a protein antigen-adjuvant mTS formulation that is compatible with human medicine. Therefore, the current formulation is a highly promising T. cruzi vaccine candidate to be tested in clinical trials.","palabras_clave":"TRYPANOSOMA CRUZI|ISCOM|TRANS-SIALIDASE|VACCINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18012,"idioma_id":4,"titulo":"Fast Determination of Harmala Alkaloids in Edible Algae by Capillary Electrophoresis Mass Spectrometry","resumen":"P { margin-bottom: 0.21cm; direction: ltr; color: rgb(0, 0, 0); widows: 2; orphans: 2; }P.western { font-family: 'Times New Roman',serif; font-size: 12pt; }P.cjk { font-family: 'Times New Roman',serif; font-size: 12pt; }P.ctl { font-family: 'Times New Roman',serif; font-size: 12pt; }                      The use of algae as a foodstuff is rapidly expanding worldwide from  the East Asian countries, where they are also applied for medical  care. Harmala alkaloids (HAlk) are a family of bioactive compounds  which can be found in the extracts of certain plants, such as wakame  (Undaria pinnatifida), an edible marine invasive algae. HAlks  are based on a characteristic &#946;-carboline structure with at least  one amino ionizable group. In this work, we report the successful  separation of a mixture of six HAlks (i.e. harmine, harmaline,  harmol, harmalol, harmane and norharmane) by capillary  electrophoresis-ion trap mass spectrometry (CE-IT-MS) in less than  eight minutes. Optimum separation in fused silica capillaries and  detection sensitivity in positive ion mode were achieved using a  background electrolyte (BGE) with 25 mM ammonium acetate (pH 7.8) and  10% (v\/v) of methanol and a sheath liquid with 60:40 (v\/v)  isopropanol:water, and 0.05% (v\/v) of formic acid. The separation  method was validated in terms of linearity, limits of detection and  quantification, repeatability and reproducibility. Later, a sample  pretreatment was carefully optimized to determine HAlks in commercial  wakame samples with excellent recoveries and repeatabilities. In the  complex wakame extracts, the MS-MS fragmentation patterns of the  different HAlks were useful to ensure a reliable identification. The  complete procedure was validated using the standard addition  calibration method, finding out matrix effects on the studied  compounds. Harmalol, harmine and harmaline were naturally present in  the samples and were quantified, at very low concentrations, ranging  from 7 to 24 µg\/kg dry algae.  \t  \t  \t  \tP { margin-bottom: 0.21cm; direction: ltr; color: rgb(0, 0, 0); widows: 2; orphans: 2; }P.western { font-family: 'Times New Roman',serif; font-size: 12pt; }P.cjk { font-family: 'Times New Roman',serif; font-size: 12pt; }P.ctl { font-family: 'Times New Roman',serif; font-size: 12pt;","palabras_clave":"Capillary Electrophoresis|MS-MS|Undaria Pinnatifida|Harmala Alkaloids"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18013,"idioma_id":4,"titulo":"Improving Use Case Specifications by means of Refactoring","resumen":"This work presents a semi-automatic tool for use case refactoring called RE-USE. This tool discovers existing quality problems in use cases and suggests a prioritized set of candidate refactorings to functional analysts. The analyst then  reviews the recommendation list and selects the most important refactoring. The tool applies the chosen refactoring and returns an improved specification. The tool effectiveness in detecting existing quality problems and recommending proper refactorings was assessed using a set of case studies related to real-world systems obtaining encouraging results.","palabras_clave":"Requirements engineering|Early aspects|Use case refactoring|Use case specification"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18014,"idioma_id":4,"titulo":"Overexpression of CD85j in TNBC patients inhibits Cetuximab-mediated NK-cell ADCC but can be restored with CD85j functional blockade","resumen":"Clinical studies suggest that triple negative breast cancer (TNBC) patients with epidermal growth factor receptor (EGFR)-expressing tumors could benefit from therapy with Cetuximab, which targets EGFR. NK cells are the primary effectors of antibody (Ab)-dependent cell-mediated cytotoxicity (ADCC) and thus play a role in Ab-based therapies. We have previously described diminished levels of Cetuximab-mediated ADCC in vitro in patients with advanced breast cancer. Here, we investigated the potential causes of this NK-cell functional deficiency. We characterized NK-cell activating\/inhibitory receptors in the peripheral blood of breast cancer patients and found CD85j inhibitory receptor overexpression. The capacity of NK cells to perform Cetuximab-triggered ADCC against TNBC cells correlated inversely with CD85j expression, even in the presence of the stimulatory cytokines IL-2 or IL-15. Hence, patients expressing high levels of CD85j had an impaired ability to lyse TNBC cells in the presence of Cetuximab. We also found that CD85j overexpression was associated with HLA-I and soluble HLA-G expression by tumors. A CD85j functional blockade with a CD85j antagonist Ab restored ADCC levels in breast cancer patients and reverted this negative effect. Our data suggest that strategies that overcome the hurdles of immune activation could improve Cetuximab clinical efficacy.","palabras_clave":"Triple negative breast cancer|NK cells CD85j"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18015,"idioma_id":4,"titulo":"Genomic and proteomic evidences unravel the UV-resistome of the poly-extremophile Acinetobacter sp. Ver3","resumen":"Ultraviolet radiation can damage biomolecules, with detrimental or even lethal effects for life. Even though lower wavelengths are filtered by the ozone layer, a significant amount of harmful UV-B and UV-A radiation reach Earth?s surface, particularly in high altitude environments. high-altitude Andean lakes (HAALs) are a group of disperse shallow lakes and salterns, located at the Dry Central Andes region in South America at altitudes above 3,000 m. As it is considered one of the highest UV-exposed environments, HAAL microbes constitute model systems to study UV-resistance mechanisms in environmental bacteria at various complexity levels. Herein, we present the genome sequence of Acinetobacter sp. Ver3, a gammaproteobacterium isolated from Lake Verde (4,400 m), together with further experimental evidence supporting the phenomenological observations regarding this bacterium ability to cope with increased UV-induced DNA damage. Comparison with the genomes of other Acinetobacter strains highlighted a number of unique genes, such as a novel cryptochrome. Proteomic profiling of UV-exposed cells identified up-regulated proteins such as a specific cytoplasmic catalase, a putative regulator, and proteins associated to amino acid and protein synthesis. Down-regulated proteins were related to several energy-generating pathways such as glycolysis, beta-oxidation of fatty acids, and electronic respiratory chain. To the best of our knowledge, this is the first report on a genome from a polyextremophilic Acinetobacter strain. From the genomic and proteomic data, an ?UV- resistome? was defined, encompassing the genes that would support the outstanding UV-resistance of this strain.","palabras_clave":"ACINETOBACTER|GENOME|EXTREMOPHILES|HIGH-ALTITUDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18016,"idioma_id":4,"titulo":"Molecular aspects of bovine cystic ovarian disease pathogenesis","resumen":"Cystic  ovarian disease (COD) is one of the main causes of reproductive failure in  cattle and causes severe economic loss to the dairy farm industry because it  increases both days-open in the postpartum period and replacement rates due to  infertility. This disease is the consequence of the failure of a mature  follicle to ovulate at the time of ovulation in the estrous cycle. This review  examines the evidence for the role of altered steroid and gonadotropin  signaling systems and the proliferation\/apoptosis balance in the ovary with  cystic structures. This evidence suggests that changes in the expression of  ovarian molecular components associated with these cellular mechanisms could  play a fundamental role in the pathogenesis of COD. The evidence also shows  that gonadotropin receptor expression in bovine cystic follicles is altered,  which suggests that changes in the signaling system of gonadotropins could play  a fundamental role in the pathogenesis of conditions characterized by altered  ovulation, such as COD. Ovaries from animals with COD exhibit a disrupted  steroid receptor pattern with modifications in the expression of coregulatory  proteins. These changes in the pathways of endocrine action would trigger the  changes in proliferation and apoptosis underlying the aberrant persistence of  follicular cysts","palabras_clave":"COD|PROLIFERATION|APOPTOSIS|GONADOTROPIN|CATTLE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18017,"idioma_id":4,"titulo":"Impaired insulin signaling pathway in ovarian follicles of cows with cystic ovarian disease","resumen":"Cystic ovarian disease (COD) is an important cause of  infertility in dairy cattle. Follicular cell steroidogenesis and proliferation  in ovulatory follicles is stimulated by hormones such as insulin and its  necessary post-receptor response. The aim of this study was to determine the  expression of insulin receptor (IR), IR substrate-1 (IRS1) and phosphatidylinositol  3-kinase (PI3K), key intermediates in the insulin pathway, in control cows and cows  with spontaneous COD and ACTH-induced COD. IR  and IRS1 mRNA levels were greater  in granulosa cells and lower in follicular cysts than in control tertiary  follicles. PI3K mRNA levels were  similar in all follicles evaluated as well as the expression of IR, IRS1  and PI3K in theca cells. Protein  expression of IR was higher in control tertiary follicles compared with the  same structures in animals with COD and with cysts. IRS1 and PI3K protein  expression showed the same pattern in tertiary and cystic follicles. However, the  protein expression of subunit alpha p85 of PI3K was greater in theca cells from  tertiary follicles than in cystic follicles. These results provide new insights  into the insulin response in cows with COD. The lower gene and protein  expressions of some insulin downstream effectors at an early stage of the  signaling pathway could negatively influence the functionality of ovaries and  contribute to follicle persistence.","palabras_clave":"BOVINO|OVARIO|COD|INSULINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18018,"idioma_id":5,"titulo":"METODOS AGRONÓMICOS Y AMBIENTALES DE DETERMINACION DE FOSFORO EN ARGIUDOLES DEL SUDESTE BONAERENSE","resumen":"Los análisis de suelo son herramientas útiles para evaluar la fertilidad edáfica y efectuar recomendaciones de fertilización (métodosagronómicos). Otros métodos, denominados ambientales, estiman el fósforo (P) que puede causar eutrofización de cuerposde agua. Es muy escasa la información que establezca la relación entre los métodos agronómicos y ambientales de análisis desuelo, para los Argiudoles del sudeste bonaerense. Se plantearon como objetivos de la investigación determinar la relación entrelos métodos agronómicos de extracción de P (Bray1, Olsen, Mehlich3) y el método ambiental (CaCl2) y determinar el riesgode contaminación con P en cultivos de papa fertilizados con P en el sudeste bonaerense. El estudio se desarrolló en lotes deproducción de papa entre los años 2005 y 2014. Para los análisis de suelo se utilizaron muestras superficiales de parcelas fertilizadasy sin fertilizar con P (0, 25, 50, 100, 150 y 200 kg P ha-1). Se determinó P extractable con los métodos Bray1, Mehlich3, Olseny CaCl2 0,01M. Bray1 extrajo la mayor cantidad de P mientras que Mehlich3, Olsen y CaCl2 extrajeron respectivamente 10, 25and 87% menos P que el Bray1. Se determinó una asociación lineal y significativa entre los métodos agronómicos entre sí(Mehlich3 = 0,80 Bray1 + 3,45; Olsen = 0,36 Bray1 + 13.57; Olsen = 0,44 Mehlich3 + 12,36). A partir de la relación entrelos métodos agronómicos y el ambiental se estimaron valores límite de P en el suelo (39, 34 y 27 mg kg-1 para Bray1, Mehlich3y Olsen, respectivamente) a partir de los cuales puede existir riesgo de pérdida de P desde el suelo a los sistemas acuáticos. Sedeterminaron concentraciones de P Bray1 que se asocian con riesgo de pérdida de P en solución (mayor a 39 mg kg-1) en sueloscultivados con papa, lo que alerta respecto al potencial impacto ambiental por fertilización con P.","palabras_clave":"DIAGNOSTICO|FOSFORO|CONTAMINACION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18019,"idioma_id":5,"titulo":"Influencia del uso de agregados reciclados en hormigón autocompactante","resumen":"El hormigón autocompactante (HAC) es un hormigón especialque fluye por su propiopeso, tomando la forma del encofrado y ocupando todos losespacios vacíos. Alcanzaun alto grado de compactación, aún en presencia de una grandensidad de armaduras,sin necesidad de vibración y sin que se produzca segregaciónde los materiales componentes.Para la elaboración de un HAC, se usan los mismos agregadosque para unhormigón convencional (HC), con la diferencia que laspartículas finas y el tipo de aditivogobiernan las características de autocompactibilidad de lamezcla fresca. Para incrementarla resistencia a la segregación de un HAC y mantener lacohesión, se requiereuna gran cantidad de finos, lo cual genera una mayor demandade agua en el hormigóndebido al aumento de la superficie específica de losagregados. Este efecto, se compensapor el empleo de aditivos reductores de agua de últimageneración, sin los cuales nosería posible elaborar un HAC","palabras_clave":"Hormigón|Autocompactante|Agregados reciclados"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18020,"idioma_id":4,"titulo":"Rational design of capillary-driven flows for paper-based microfluidics","resumen":"The design of paper-based assays that integrate passive pumping requires a precise programming of the fluid transport, which has to be encoded in the geometrical shape of the substrate. This requirement becomes critical in multiple-steps processes, where fluid handling must be accurate and reproducible for each operation. The present work theoretically investigates the capillary imbibition in paper-like substrates to better understand fluid transport in terms of the macroscopic geometry of the flow domain. A fluid dynamic model was derived for homogeneous porous substrates with arbitrary cross-sectional shapes, which allows one to determine the cross-sectional profile required for a prescribed fluid velocity or mass transport rate. An extension of the model to slit microchannels is also demonstrated. Calculations were validated by experiments with prototypes fabricated in our lab. The proposed method constitutes a valuable tool to the rational design of paper-based assays.","palabras_clave":"Microfluidica en papel|Imbibicion capilar|Diseño de microflujos|Laboratorios en chips"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18021,"idioma_id":4,"titulo":"Effect of solution pH on the dynamic of biosorption of Cr(VI) by living plants of Salvinia minima","resumen":"Salvinia minima is a widely distributed floating fern that bioaccumulates high concentrations of heavy metals and is a promising species for Cr(VI) removal from polluted waters. Metal bioaccumulation efficiency of aquatic plants can be affected by different factors such as surrounding pH and metal concentration. In this study we investigated the effect of solution pH on the biosorption and reduction of Cr(VI) in living plants of S. minima under both pH-stat (buffered) and pH-shift (unbuffered) conditions.  Plants were exposed to 0, 5 and 20 mg L1 Cr(VI) concentrations for 7 days under controlled conditions at pH 4.0, 6.0 and 7.6. Cr(VI) was determined using 1,5-diphenylcarbazide in presence and absence of KMnO4. Cr(III) concentration was estimated as the difference between Crtotal [Cr(VI) + Cr(III)] (with KMnO4) and Cr(VI) (without KMnO4) concentrations. Metal biosorption was significantly higher in acid buffered solution than in unbuffered solution, but the biosorption pattern was different indicating that solution pH could be a key factor controlling the removal of Cr(VI) by S. minima. The pH of acid unbuffered  Cr(VI)-containing solutions was significantly increased during Salvinia growth. Contrarily no significant changes of pH were observed in unbuffered solutions without Cr(VI). Reduction of Cr(VI) to Cr(III) was significantly higher at lower pH. Visual symptoms of Cr(VI)-induced damage were less evident at lower pH. Results demonstrated that S. minima can survive and remove Cr(VI) at low pH values. This work indicates that selection of suitable aquatic macrophytes for potential application in heavy metal phytoremediation requires an additional focus regarding interactions among metal, solution pH, and plant performance.","palabras_clave":"Biosorption|Cr|Desorption|pH|Salvinia minima|Visual symptoms"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18022,"idioma_id":4,"titulo":"Differential effects of Cr(VI) on the ultrastructure of chloroplast and plasma membrane of  Salvinia minima growing in summer and winter. Relationships with lipid peroxidation, electrolyte leakage, photosynthetic pigments, and carbohydrates","resumen":"Seasonal variations of chloroplast thylakoids    and plasma membrane ultrastructure and changes in    some biochemical parameters (e.g., metal accumulation,    photosynthetic pigments, carbohydrates, lipid peroxida-    tion, and electrolyte leakage) were studied in fronds of    Salvinia minima    plants exposed to increasing concen-    trations of Cr(VI) in both winter and summer. Disorga-    nization of stacked (grana) and unstacked (stroma la-    mellae) thylakoids was greater in winter chloroplasts    than in summer chloroplasts. Plasma membrane was    less affected than thylakoids. Photosynthetic pigments,    lipid peroxidation, soluble sugars, and starch were af-    fected differently in winter and summer. Our results    suggest that much greater ultrastructural alterations and    changes in metabolite levels occurring in winter fronds    are produced by higher oxidative stress resulting from    the interactive effectbetween low temperature,low solar    irradiance, and Cr(VI) toxicity, rather than from metal    accumulation per se. Seasonal differences occurring in    chloroplast ultrastructure and metabolite concentrations    were discussed in relation to metabolic implications.","palabras_clave":"Chloroplast ultrastructure|Chlorophyll|Cr(VI)|Electrolyte leakage|Lipid peroxidation|Starch"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18023,"idioma_id":4,"titulo":"Versatility of Streptomyces sp M7 to bioremediate soils co-contaminated with Cr(VI) and lindane","resumen":"The aim of this work was to study the impact of environmental factors on the bioremediation of Cr(VI) and lindane contaminated soil by an actinobacterium Streptomyces sp. M7, in order to optimize the process.  Soil samples were contaminated with 25 &#61549;g Kg-1 of lindane and 50 mg Kg-1 of Cr(VI) and inoculated with Streptomyces sp. M7. The lowest inoculum concentration wichh simultaneously produced highest removal of Cr(VI) and lindane was 1 g Kg-1. The influence of physical and chemical parameters was assessed using a full factorial design. The factors and levels tested were: Temperature: 25, 30, 35 ºC; Humidity: 10%, 20%, 30%; Initial Cr(VI) concentration: 20, 50, 80 mg Kg-1; Initial lindane concentration: 10, 25, 40 &#61549;g Kg-1.   Streptomyces sp. M7 exhibited strong versatility, showing the ability to bioremediate co-contaminated soil samples at several physicochemical conditions. Streptomyces sp. M7 inoculum size was optimized. Also, it was fitted a model to study this process, and it was possible to predict the system performance, knowing the initial conditions. Moreover, optimum temperature and humidity condition for the bioremediation soil with different concentrations of Cr(VI) and lindane were determined. Lettuce seedlings were a suitable biomarker to evaluate the contaminants mixture toxicity. Streptomyces sp. M7 carried out a successful bioremediation, which was demonstrated through ecotoxicity tests with Lactuca sativa.","palabras_clave":"Bioremediation|Actinobacteria|Lindane|Chromium"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18024,"idioma_id":4,"titulo":"Effect of xantham gum, steviosides, clove and cinnamon essential oils on the sensory and microbiological quality of a low sugar tomato jam","resumen":"The partial or total decrease of sugar content in the formulation of jams affects their physical, chemical and microbiological stability. In order to minimize these technological problems, we studied the effect of xanthan gum (XG), steviosides, cinnamon (CO), and clove (CLO) essential oils on the sensory and microbiological quality of a low sugar tomato jam. Levels of 0.250 g\/100 g steviosides and 0.450 g\/100 g XG showed maximum score of overall acceptability of jam. The combination of essential oils produced synergistic and additive effects in vitro on growth of Z. bailii and Z. rouxii, respectively. However, in the jam, CO was more effective and CLO did not modify the CO action. Cell surface was one of the sites of action of CO since a decrease in yeast cell surface hydrophobicity was observed. From the microbiological and sensory points of view, 0.0060 g\/100 g CO showed the maximum score of jam overall acceptability and did not cause yeast inactivation but it could be useful as an additional stress factor against yeast post ? process ontamination. The adequate levels of XG, steviosides, and CO can improve the quality of a low sugar jam formulation.","palabras_clave":"STEVIOSIDES|XANTHAM GUM|CINNAMON OIL|LOW SUGAR JAM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18025,"idioma_id":5,"titulo":"Un estudio sobre cambios planificados en la enseñanza universitaria. Origen y desarrollo de innovaciones educativas","resumen":"    El  artículo expone parte de resultados de un trabajo de investigación cuyo  objetivo general es comprender la  dinámica de los procesos de cambio en el desarrollo de innovaciones educativas  en la universidad, desde la perspectiva de los propios actores involucrados.  Los objetivos específicos son: interpretar cómo los actores institucionales  reconstruyen las innovaciones desde su memoria colectiva; identificar fases o  momentos en el desarrollo de las innovaciones; distinguir acontecimientos,  acciones, conocimientos construidos durante el proceso innovador que permiten  explicar el pasaje de una fase a otra y generar una tipología de trayectorias  de innovaciones educativas. Constituye un estudio cualitativo de casos  múltiples, siendo los mismos diez experiencias educativas innovadoras que se  enmarcan en un Programa Institucional de la Universidad Nacional de Río Cuarto  denominado Proyectos de Innovación e Investigación para el  Mejoramiento de la Enseñanza de Grado. Como resultado construimos dos tipos  de trayectorias de innovaciones que denominamos recursiva e incremental.  ","palabras_clave":"Educación superior|Calidad de la educación|Innovaciones educativas|Planeación institucional"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18026,"idioma_id":4,"titulo":"Simultaneous Separation of Ergot Alkaloids by Capillary Electrophoresis After Cloud Point Extraction From Cereal Samples","resumen":"A new and sensitive analytical methodology for ergot alkaloids determination from cereal  samples based on Cloud Point Extraction prior to Capillary Electrophoresis-UV absorbance  was developed. The methodology involves extraction under acid conditions and subsequent  preconcentration by applying a simple, rapid and environmentally friendly low volume  surfactant extraction procedure. After extraction, CE analysis was carried out by  performing dilutions on preconcentrated surfactant rich phase, achieving a single peak or  simultaneous alkaloids determination. A real preconcentration factor of 22 of total ergot  alkaloids was obtained, demonstrating the efficiency of this methodology. The limits of  detection were 2.6 and 2.2 &#956;g\/kg for ergotamine and ergonovine, respectively. Validation  procedure revealed suitable linearity, accuracy and precision. The average extraction and  clean-up recoveries were compared with the theoretical values and were better than 92%.  This method was successfully applied to the determination of ergot alkaloids in different  varieties of commercial flour samples, two grain samples and one of the leading brands  cereal based product for infant feeding. The high sensitivity achieved for ergot alkaloids  determinations in real samples suggests CPE procedure as an interesting approach to2  improve CE-UV visible detection limits. Moreover, the whole process could be considered  as a contribution to green chemistry because non-organic solvents were involved,  demonstrating its great potential over conventional techniques.","palabras_clave":"Capillary electrophoresis|Cereals|Ergot alkaloids|Ergotamine"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18027,"idioma_id":5,"titulo":"¿Quienes son los desaforados? Una mirada ampliada al concepto de violencia y  juventud sesentista desde la prensa masiva","resumen":"El presente artículo aborda las diferentes representaciones de  la juventud a través de las opiniones del público lector de clases medias en la prensa periódica. Asimismo, tiende a reflexionar sobre la ampliación del concepto de violencia analizada a través de las opiniones entre los sectores politizados de la sociedad con la ?sociedad común?. El interés está puesto en revisar el tono del lenguaje que cruzó de modo horizontal a la sociedad argentina para ver en él, algunos patrones internos y conexiones con otros aspectos de la cultura política sesentista.","palabras_clave":"PRENSA|VIOLENCIA|JUVENTUD|CLASES MEDIAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18028,"idioma_id":4,"titulo":"Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle","resumen":"The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs.","palabras_clave":"MASTITS|MILK|POLYMORPHISMS|RESISTANCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18029,"idioma_id":4,"titulo":"Volcanic ash as flux in clay based triaxial ceramic materials, effect of the firing temperature in phases and mechanical properties","resumen":"The study of possible incorporation of nontraditional starting powders is a contribution to the rational utilization of raw materials in the ceramicindustry. The technological properties of solid waste problems (both urban and industrial) in many cases are not correctly studied and reported. The main objective of the present work is to study and demonstrate the applicability of the volcanic ash for the fabrication of clay based ceramic materials as the &#64258;ux fraction for replacing feldspar. This paper deals with a particular raw material (volcanic ash) but the results can be extended to materials resulting from similar sources and properties. The milled volcanic ash was characterized and employed as a &#64258;ux agent replacing feldspar in a model triaxial ceramic material (clay?quartz?&#64258;ux) formulation. Previously, the volcanic ash was characterized. Differential Thermal Analysis and termogravimetry (DTA?TG) in order to establish the &#64257;ring conditions were also carried out. Afterwards, the thermal treatments (900?1300 1C) conditions were studied: the &#64257;ring temperatures were correlated with the shrinkage?porosity?density evolution.The crystalline phase thermal evolution was also established and compared to the one observed in the model feldspar based material. Finally the mechanical properties of the obtained materials (&#64258;exural strength and dynamic elastic modulus) were evaluated. The results permitted tocorroborate the applicability and establish some of the technological properties of ash based ceramic material.industry. The technological properties of solid waste problems (both urban and industrial) in many cases are not correctly studied and reported. The main objective of the present work is to study and demonstrate the applicability of the volcanic ash for the fabrication of clay based ceramic materials as the &#64258;ux fraction for replacing feldspar. This paper deals with a particular raw material (volcanic ash) but the results can be extended to materials resulting from similar sources and properties. The milled volcanic ash was characterized and employed as a &#64258;ux agent replacing feldspar in a model triaxial ceramic material (clay?quartz?&#64258;ux) formulation. Previously, the volcanic ash was characterized. Differential Thermal Analysis and termogravimetry (DTA?TG) in order to establish the &#64257;ring conditions were also carried out. Afterwards, the thermal treatments (900?1300 1C) conditions were studied: the &#64257;ring temperatures were correlated with the shrinkage?porosity?density evolution.The crystalline phase thermal evolution was also established and compared to the one observed in the model feldspar based material. Finally the mechanical properties of the obtained materials (&#64258;exural strength and dynamic elastic modulus) were evaluated. The results permitted tocorroborate the applicability and establish some of the technological properties of ash based ceramic material.The crystalline phase thermal evolution was also established and compared to the one observed in the model feldspar based material. Finally the mechanical properties of the obtained materials (&#64258;exural strength and dynamic elastic modulus) were evaluated. The results permitted tocorroborate the applicability and establish some of the technological properties of ash based ceramic material.corroborate the applicability and establish some of the technological properties of ash based ceramic material.","palabras_clave":"CERAMIC|FLY ASH|SINTERING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18030,"idioma_id":5,"titulo":"Modificación de Variables productivas por inclusión del 'poroto caupí' (Vigna unguiculata) en la alimentación de cerdos.","resumen":"It is recommended that for animal feeding the ingredients in the diet should be obtained in the same region of the exploitation. In northeastern Argentina it is possible to use cowpea beans (Vigna unguiculata) as a protein resource. The objective of this trial was to verify the suitability of ?cowpea beans? to replace expeller soybean in different proportions in the diet of growing pigs, measuring parameters of productive performance. For the trial a totally randomized blocks design was used. It lasted 30 days: 9 days for adaptation and 21 days for measurements. The experience included 12 animals and 3 diets; T1: basal diet (BD) made with ground corn (66%) and soybean expeller (29%), T2 and T3: BD to which 50% and 75% of soybean expeller were replaced by cowpea beans, respectively. Statistical analysis was performed with the InfoStat software. The analysis showed that among T1, T2 and T3 treatments there were not significant differences (p>0.05) for the daily weight gain (0.25; 0.25 and 0.28 kg\/day respectively), daily food intake (1.06; 0.99 and 1.00 kg DM\/day) neither nutritious conversion (4.21; 3.44 and 4.64 kg). This allows us to conclude that the use of ?cowpea beans? at different levels of substitution of soybean expeller is a viable option for growing pigs.","palabras_clave":"PIG|ALTERNATIVE FOOD|PROTEIN|PRODUCTIVE PARAMETERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18031,"idioma_id":10,"titulo":"CARGA ÓTIMA DE FRUTOS NA MACIEIRA 'PRINCESA' DE BAIXO REQUERIMENTO EM FRIO INVERNAL: RESULTADOS PRELIMINARES","resumen":"The aim of this work was to evaluate the effect of crop load on yield, fruit size, vegetative growth and return to bloom of low-chill apple (Malus × domestica Borkh.), cv. 'Princesa'. During 2009 and 2010 crop load was manually adjusted from 1 to 9 fruits per unit of trunk cross-sectional area (TSCA). Fruit yield was positively related to crop load, but mean fruit weight decreased with increasing crop load. The proportion of small and middle-sized fruits increased with crop load reaching 10% and 35% respectively of the total yield at the highest crop load. However the proportion of large-sized fruits did not change with the increase in the number of fruit per unit of TSCA. Shoot length at 60 days after harvest was negatively related to crop load whereas return to bloom was not affected. These results demostrates that the optimum crop load for 'Princesa' apple ranges between 5 to 9 fruits per unit of TSCA.","palabras_clave":"RALEIO MANUAL|QUALIDADE DE FRUTOS|CRESCIMENTO VEGETATIVO|INVERNO AMENO|MALUS DOMESTICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18032,"idioma_id":5,"titulo":"Participación social en turismo: el caso de la comunidad de Carlos Keen (Argentina) en el marco del programa ?Pueblos Turísticos?","resumen":"Este estudio pretende indagar acerca de las características de los procesos participativos en el marco de un programa público provincial enfocado al desarrollo turístico. Para tal fin, y mediante un abordaje cualitativo, se propone analizar el alcance de la participación, los modos de comunicación y decisión y la extensión de la autoridad en la localidad de Carlos Keen (Buenos Aires), área de aplicación del programa provincial Pueblos Turísticos. Los resultados permiten establecer que si bien se trata de un programa con alto grado de inclusividad participativa, donde se han generado espacios de comunicación y deliberación conjunta, esta circunstancia se ve condicionada por la limitada participación de la comunidad.","palabras_clave":"TURISMO|POLÍTICAS PÚBLICAS|PARTICIPACIÓN SOCIAL|PROVINCIA DE BUENOS AIRES|PROGRAMA PUEBLOS TURÍSTICOS|CARLOS KEEN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18033,"idioma_id":4,"titulo":"ANDROGEN RECEPTOR EXPRESSION IN PITUITARY OF MALE VISCACHA IN RELATION TO GROWTH AND REPRODUCTIVE CYCLE","resumen":"The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in  relation to growth and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis. Pituitary  glands from fetus, immature, prepubertal, and adult viscachas during their reproductive cycle were used. In the fetal PD, the  immunoreactivity (ir) was mainly cytoplasmic. In immature and prepubertal animals, AR-ir was cytoplasmic (ARc-ir) and nuclear  (ARn-ir) in medial region. In adult animals, ARn-ir cells were numerous at caudal end. AR regionalization varied between the  PD zones in relation to growth. In immature animals, the ARn-ir increased whereas the cytoplasmic expression decreased in  relation to the fetal glands. The percentage of ARc-ir cells increased in prepubertal animals whereas the nuclear AR expression was  predominant in adult viscachas. The AR expression changed in adults, showing minimum percentage in the gonadal regression  period. The variation of nuclear AR expression was directly related with testosterone concentration. These results demonstrated  variations in the immunostaining pattern, regionalization, and number of AR-ir cells throughout development, growth, and  reproductive cycle, suggesting the involvement of AR in the regulation of the pituitary activity of male viscacha.","palabras_clave":"ANDROGEN|RECEPTOR|PITUITARY|VISCACHA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18034,"idioma_id":4,"titulo":"New palynological records from the glaciomarine deposits of the El Paso Formation (Late Serpukhovian-Bashkirian) In Argentine Precordillera: Biostratigraphical Implications","resumen":"Se presenta nueva información palinológica para la Formación El Paso. Esta unidad aflora en el sector austral de la Sierra de Barreal, provincia de San Juan, Argentina (Cuenca Calingasta- Uspallata), y las asociaciones palinológicas se recuperaron de la parte media a superior de la sección. Contiene abundantes esporas trilete (75?90%) e hilate (1?5%), asignadas a Cyclogranisporites rinconadensis, Apiculatisporis variornatus, Raistrickia rotunda, Tricidarisporites gutii,Ahrensisporites sp. cf. A. cristatus, Cristatisporites stellatus, Indotriradites volkheimeri, Vallatisporites ciliaris y Psomospora detecta, entre otros. También,granos de polen subordinados (1,5?20%): Circumplicatipollis plicatus, Costatascyclus crenatus, Plicatipollenites sp. cf. P. malabarensis, Potonieisporitesspp., Divarisaccus sp. cf. D. stringoplicatus. Acritarcos retrabajados y autóctonos (e.g., Cymatyogalea sp., Gorgonisphaeridium sp.,Verhyachium sp.) y algas Zygnematalean (Tetraporina sp., Brazilea scisa) estan presentes con menos de 2,5%. Se propone una edad serpukhoviana tardía?bashkiriana y la correlación con la Subzona A de la Biozona Raistrickia densa-Convolutispora muriornata (DM) para las asociaciones de la Formación El Paso.","palabras_clave":"Palynology|Biostratigraphy|Carboniferous. |El Paso Formation|Argentine Precordillera"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18035,"idioma_id":4,"titulo":"Optical polarization of solar type stars with debris disks","resumen":"We report optical aperture polarimetry for 34 southern hemisphere main-sequence stars with debris disks, in addition to 54 stars without evidence of disk. These sets of stars are combined with other of 109 stars from the northern hemisphere, obtained from  the literature, to build two samples of 51 and 97 solar-type stars with and without debris disks. The distributions of polarization values for the samples with and without disks show no significant statistical difference, within the precision of our observations. However, we identify a sub-sample of 9 stars (d  less than 50 pc) with disks that have polarization levels above the median for the sample with disk and that are not appropriately reproduced by Serkowski´s interstellar law. These stars are candidates to have intrinsic polarization. In this case the debris disks in these stars may be populated by small dust with sizes of about 0.1 micron.","palabras_clave":"INFRARED: STARS|KUIPER BELT: GENERAL|TECHNIQUE: POLARIMETRY|ZODIACAL DUST"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18036,"idioma_id":4,"titulo":"Impact of Iron Incorporation on 2-4 nm Size Silicon Nanoparticles Properties","resumen":"Iron-containing silicon nanoparticles were synthesized in an attempt to understand the effect of iron on the silicon nanoparticle (SiNP) photoluminescence and singlet-oxygen generation capacity. A wet chemical oxidation procedure of the sodium silicide precursor, obtained from the thermal treatment of a mixture of sodium, silicon, and an iron(III) organic salt under anaerobic conditions, was employed. Surface-oxidized and propylamine-terminated SiNPs were characterized using high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, time-resolved and steady-state photoluminescence, and time-correlated fluorescence anisotropy. On the basis of differences in the morphology, crystal structure, density, and photoluminescence spectrum, two distinct types of SiNPs were identified in a given synthesis batch: iron-free and iron-containing SiNPs. The results show that iron is inhomogeneously incorporated in the SiNPs leading to an efficient photoluminescence quenching. Emission arrives mainly from 2 nm size iron-free SiNPs. The nanoparticles were shown to generate singlet oxygen (1O2) upon 355 nm irradiation, though they were able to quench 1O2. Analysis of cytotoxicity using MTT assay on rat glioma C6 cells showed a strong dependence on the nature of the surface groups, as 100 &#956;g\/mL of propylamine-terminated iron-containing SiNPs leads to 85% decrease in cell viability while equal amounts of surface oxidized particles induced a 35% of cell death.","palabras_clave":"IRON QUENCHING|OPTICAL PROPERTIES|SURFACE CHEMISTRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18037,"idioma_id":4,"titulo":"Physiological and biochemical responses of Eichhornia crassipes exposed to Cr (III)","resumen":"Abstract The effect of exposure of Eichhornia crassipesto Cr (III) was assessed by measuring changes in photosyntheticpigments, malondialdehyde, superoxide dismutase,glutathione reductase, catalase, and guaiacolperoxidase activities, as well as Cr concentration intissues. Cr concentration in roots was significantlyhigher than in aerial parts and increased with Cr concentrationin water. Photosynthetic pigments increasedsignificantly, whereas the activities of antioxidant enzymesvaried differently in plant tissues. Low Cr concentrationsinduced a rapid response of E. crassipesduring short-term exposure, implying that the antioxidantsystem conferred redox homeostasis. Resultsshowed that Cr (III) was more toxic at the two highestconcentrations and long-term exposure, while it was notharmful but beneficial at the two lowest concentrationsand short-term exposure. This work concludes thatE. crassipes was able to grow under Cr (III) stress byprotecting itself with an increase in the activity of itsantioxidant system.","palabras_clave":"Oxidative stress| Hormesis |Antioxidant enzyme defense system .|Macrophyte|Bioaccumulation |Lipid peroxidation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18038,"idioma_id":4,"titulo":"Confinement Effects of Ion Tracks in Ultrathin Polymer Films","resumen":"We show direct experimental evidence that radiation effects produced by single MeV heavy ions on a polymer surface are weakened when the length of the ion track in the material is confined into layers of a few tens of nanometers. Deviation from the bulk (thick film) behavior of ion-induced craters starts at a critical thickness as large as sim40 nm, due to suppresion of long range additive effects of excited atoms along the track. Good agreement was found between the experimental results, molecular dynamic simulations, and an analytical model.","palabras_clave":"polymer films|ion track|irradiation|high energy particles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18039,"idioma_id":4,"titulo":"In vitro and in vivo cyto-genotoxic effects of hot aqueous extract of Achyrocline satureioides (Lam.) DC","resumen":"In this work we extend the toxicological studies of hot aqueous extract of A. satureioides (As-HAE) evaluating cytotoxic and apoptotic effects on human peripheral blood mononuclear cells (PBMCs). We also determine genotoxic action of this extract in vivo. In addition, the extract was chemically characterized. Finally, we established a comparison with previous data of cold aqueous extract. The As-HAE induced cytotoxicity on PBMCs determined by trypan blue dye exclusion (CC50 = 653&#120583;g\/mL) and MTT (CC50 = 588&#120583;g\/mL) assays being more toxic than cold extract. However, As-HAE as well as cold extract did not induce apoptosis measured by Hoechst 33258 staining, TUNEL assay, and DNA fragmentation analysis.The in vivo micronucleus test showed that As-HAE exerted cytogenotoxic effects on bone marrow of mice, contrary to what was observed with cold extract. The chemical study of As-HAE allowed identifying the flavonoids found in cold extract: luteolin, quercetin, and 3-O-methylquercetin, but at higher concentrations. We suggest that toxic effects induced by As-HAE could be due to high concentrations of these flavonoids.Given that As-HAE is the most used in folkloricmedicine, its administration should be controlled in order to prevent potential cell damage.","palabras_clave":"ACHYROCLINE SATUREIOIDES|CYTOTOXICITY|HPLC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18040,"idioma_id":4,"titulo":"BLOCKADE OF MULTIDRUG RESISTANCE ASSOCIATED PROTEINS AGGRAVATES ACUTE PANCREATITIS AND BLUNTS ATRIAL NATRIURETIC FACTOR BENEFITIAL EFFECT IN RATS: ROLE OF MRP4\/ABCC4","resumen":"We previously reported that atrial natriuretic factor (ANF) stimulates secretin-evoked cAMP efflux through multidrug resistance-associated protein 4 (MRP4) in the exocrine pancreas. Here we sought to establish in vivo whether this mechanism was involved in acute pancreatitis onset in the rat. Rats pretreated with or without probenecid (MRPs general inhibitor) were infused with secretin alone or with ANF. A set of these animals were given repetitive caerulein injections to induce acute pancreatitis. Plasma amylase and intrapancreatic trypsin activities were measured and histological examination of the pancreas performed. Secretin alone activated trypsinogen but induced no pancreatic histological changes. Blockade by probenecid in secretin-treated rats increased trypsin and also induced vacuolization, a hallmark of acute pancreatitis. ANF prevented the secretin response but in the absence of probenecid. In rats with acute pancreatitis, pre-treatment with secretin aggravated the disease but ANF prevented secretin-induced changes. Blockade of MRPs in rats with acute pancreatitis induced trypsinogen activation and larger cytoplasmic vacuoles as well as larger areas of necrosis and edema that were aggravated by secretin but not prevented by ANF. The temporal resolution of intracellular cAMP levels seems critical in the onset of acute pancreatitis since secretin-evoked cAMP in a context of MRPs inhibition makes the pancreas prone to injury in normal rats and aggravates the onset of acute pancreatitis. Present findings support a protective role for ANF mediated by cAMP extrusion through MRP4 and further suggest that the regulation of MRP4 by ANF would be relevant to maintain pancreatic acinar cell homeostasis.","palabras_clave":"ACUTE PANCREATITIS|ATRIAN NATRIURETIC FACTOR|MRP4\/ABCC4"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18041,"idioma_id":4,"titulo":"Photoremoval of Protecting Groups: Mechanistic Aspects of 1,3- Dithiane Conversion to a Carbonyl Group","resumen":"Photodeprotection of 1,3-dithianes in the presence of thiapyrylium was performed to return to the parent carbonyl compound, and the mechanism was studied by steady state photolysis, laser flash photolysis, and theoretical calculations. Electron transfer from dithianes to triplet sensitizers is extremely fast, and the decay of dithiane radical cations was not affected by the presence of water or oxygen as the consequence of a favorable unimolecular fragmentation pathway. Similar behaviors were observed for dithianes bearing electron-releasing or electron-withdrawing substituents on the aryl moiety, evidenced by C&#8722;S bond cleavage to form a distonic radical cation species. The lack of reaction under nitrogen atmosphere, requirement of oxygen for good conversion yields, inhibition of the photodeprotection process by the presence of pbenzoquinone, and absence of a labeled carbonyl final product when the reaction is performed in the presence of H218O all suggest that the superoxide anion drives the deprotection reaction. Density functional theory computational studies on the  reactions with water, molecular oxygen, and the superoxide radical anion support the experimental findings.","palabras_clave":"Photochemistry|Carbonyl Groups|Radical Cation|Dithiane"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18042,"idioma_id":4,"titulo":"Regulation of the Norepinephrine Transporter by Endothelins: A Potential Therapeutic Target","resumen":"Neuronal norepinephrine (NE) uptake is a crucial step in noradrenergic neurotransmission that regulates NE concentration in the synaptic cleft. It is a key mechanism mediated by the NE transporter (NET) which takes the neurotransmitter into the presynaptic neuron terminal or the adrenal medulla chromaffin cell. The activity of NET is short and long terms modulated by phosphorylation mediated by protein kinases A, C, and G and  calcium?calmodulin-dependent protein kinase, whereas the transporter availability at the cell surface is regulated by glycosylation. Diverse neuropeptides like angiotensins II, III, and 1?7, bradykinin, natriuretic peptides, as well as endothelins (ETs) regulate a wide variety of biological effects, including noradrenergic transmission and in particular neuronal NE uptake. Diverse reports, including studies from our laboratory, show that ETs differentially modulate the activity and expression of NET not only in normal conditions but also in diverse cardiovascular diseases such as congestive heart failure and hypertension. Current literature supports a key role for the interaction between ETs and NE in maintaining neurotransmission homeostasis and further suggests that this interaction may represent a potential therapeutic target for various diseases, particularly hypertension","palabras_clave":"Regulation of the Norepinephrine Transporter|Endothelins|NEURONAL NE UPTAKE|NE inactivation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18043,"idioma_id":4,"titulo":"Species delimitation in the Andean grasshopper genus Orotettix Ronderos & Carbonell (Orthoptera: Melanoplinae): an integrative approach combining morphological, molecular, and biogeographic data.","resumen":"The reciprocal illumination nature of integrative taxonomy through hypothesis testing,  corroboration, and revision is a powerful tool for species delimitation since more than one source  has to support the hypothesis of a new species. In this study, we applied an integrative taxonomy  approach combining molecular and morphological data sets with distributional patterns to examine  the level of differentiation between and within the grasshopper Orotettix species. Orotettix was  described based on five valid species distributed in the Andes of Peru. In our study, initially a  molecular-based hypothesis was postulated and tested against morphological data and geographic  patterns of distribution. Results from molecular and morphological analyses showed agreement  among the species delimitation in Orotettix, and were also consistent with the geographic  distribution. The analyses allowed us to delimit five new species for the genus (O. lunatus n. sp., O.  astreptos n. sp., O. colcaensis n. sp., O. paucartambensis n. sp., and O. dichrous n. sp.) from the  Eastern and Western Cordilleras of Peru. Besides, we provide critical knowledge on the  phylogenetic relationships and distribution of the genus and conduct a revision of Orotettix.","palabras_clave":"ACRIDIDAE|ANDES|INTEGRATIVE TAXONOMY|MITOCHONDRIAL DNA|MALE GENITALIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18044,"idioma_id":5,"titulo":"La familia Cactaceae en Argentina: patrones de diversidad y prioridades políticas para su conservación","resumen":"En este trabajo se utilizó la riqueza de especies y el endemismo de las especies de cactáceas argentinas para seleccionar las provincias con la mayor prioridad para la conservación de esta familia de plantas en el país. Además, se evaluó el papel de la diversidad de cactáceas como sustitutos de la diversidad de plantas dicotiledóneas de Argentina. La riqueza de especies (número de especies) y el endemismo (número de especies endémicas) fueron determinadas para cada una de las 24 provincias de Argentina. Un total de 15 provincias fueron seleccionadas como prioritarias con base en todas las especies de cactáceas y 14 con base en las especies endémicas. La provincia de Salta presenta la mayor riqueza de especies y endemismo. Las especies endémicas son un buen sustituto de la diversidad de cactáceas. De igual manera, las cactáceas son un buen sustituto de la diversidad de las plantas dicotiledóneas.","palabras_clave":"Cactaceas|Argentina|Patrones de diversidad"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18045,"idioma_id":5,"titulo":"evaluacion de la respuesta agronomica de plantas de tomate injertadas en cultivo bajo invernadero","resumen":"Evaluación de la respuesta agronómica de plantas de tomate injertadas en cultivo bajo invernadero Autores: Susana Martínez;* Mariana Garbi; María Cecilia Grimaldi; Javier Somoza; Gabriela Morelli; Cerisola Cecilia      El  trabajo  tuvo  como  objetivo  evaluar  el  crecimiento,  rendimiento  y  comportamiento  fenológico  de  plantas  de   tomate injertadas cultivadas bajo cubierta. Se condujeron tres ensayos en un invernadero parabólico ubicado en   La Plata, Buenos Aires, Argentina (34°58? S; 57°54?W). Los tratamientos fueron plantas del híbrido Elpida (Enza   Zaden®) injertadas sobre pie Efialto (Enza Zaden®) y Elpida sin injertar, usado como testigo. Las plantas testigo   se condujeron a una rama (2 plantas.m  -2  ) y las injertadas a dos ramas (1 planta.m  -2  ). Se registró la altura de   planta,  el  rendimiento  total  y  por  categorías  comerciales  y  la  fecha  de  floración  y  fructificación  por racimo,   calculando la cantidad de días transcurridos entre  transplante y cada una de las fases. Se utilizó un  diseño en   bloques completos aleatorizados con 4 repeticiones.La cantidad de días entre fases se evaluó con la prueba no   paramétrica de Kruskal Wallis (p &#8804;0,05). Los datos de rendimiento y altura de plantase sometieron a análisis de   la  varianza  (p  &#8804; 0,05).  Las  plantas  injertadas  presentaron  un  incremento  estadísticamente  significativo  en  la   cantidad de días requeridos para alcanzar la floración y fructificación del primer, tercer y quinto racimo solo en el   primer  ensayo.  La  altura,  el  rendimiento  total  y  por  categorías  comerciales  no  presentaron  diferencias entre   tratamientos. El injerto del cv. Elpida sobre el pie Efialto produjo plantas más vigorosas que pueden conducirse a   dos  tallos  reduciendo  la cantidad  de plantas necesarias  y  manteniendo niveles  de producción  equivalentes  al   híbrido sin injertar.","palabras_clave":"Injerto|portainjerto|fenologia|vigor"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18046,"idioma_id":4,"titulo":"Native species as goods","resumen":"There is ongoing discussion regarding whether conservation professionals should care about the differences between native and non-native species, despite a large literature that shows the importance of these differences. If one accepts the integration of non-native species in cultural traditions and native landscapes, it implies that one accepts the eventual loss of native biodiversity and traditions. Acceptance of such a loss also raises ethical issues regarding the loss of knowledge of the use of native species, akin to the loss of an aboriginal language, both of which may be considered unacceptable. Given the long period it takes for some non-native species to fully reveal their impacts, it also seems unwise to ignore potentially unpredictable outcomes arising from the use of non-native species. When a non-native species is considered a resource, it entrains ecological and cultural consequences that are difficult to remediate. In many instances, if the true value of native species were recognized, their conservation would be much more likely.","palabras_clave":"NATIVE SPECIES|EXOTIC SPECIES|VALUE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18047,"idioma_id":4,"titulo":"Description of a new species of Sparassocynus (Marsupialia: Didelphoidea: Sparassocynidae) from the late Miocene of Jujuy (Argentina) and taxonomic review of Sparassocynus heterotopicus from the Pliocene of Bolivia","resumen":"A new species of sparassocynid marsupial, Sparassocynus maimarai n. sp. from the lateMiocene of Maimará Formation (Jujuy Province, Argentina) is described from a leftmandibular fragment with a complete p2?m4 series. It differs from the remaining species ofthe genus S. bahiai (Montehermosan? late Miocene\/early Pliocene ? of Buenos AiresProvince, Argentina) and S. derivatus (Chapadmalalan and Marplatan?Pliocene of BuenosAires Province) by its smaller size, the relatively longer m1, the presence of a cingulumlingual to the paraconid on the m1?3, and its more robust entoconids. As part of this studythe taxonomic status of Sparassocynus heterotopicus (Montehermosan, Umala, Bolivia;Pliocene) was reviewed concluding that this taxon should be referred to as ?Sparassocynus?heterotopicus and considered a Didelphoidea of uncertain affinities. Sparassocynusmaimarai n. sp. is the oldest records of the genus, adding new information to evaluate theorigins and early diversification of sparassocynids. Sparassocynus maimarai n. sp. wasrecovered with precise stratigraphic control which remarks its potential biostratigraphicsignificance to the temporal correlations between Maimará Formation and other Mio?Pliocene stratigraphic units from the northwestern Argentina.","palabras_clave":"Neogene|Metatheria|South America|Sparassocynus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18050,"idioma_id":4,"titulo":"Harmonic demodulation and minimum enhancement factors in field-enhanced near-field optical microscopy","resumen":"Field-enhanced scanning optical microscopy relies on the designand fabrication of plasmonic probes which had to provideoptical and chemical contrast at the nanoscale. In order todo so, the scattering containing the near-field informationrecorded in a field-enhanced scanning optical microscopy experiment,has to surpass the background light, always presentdue to multiple interferences between the macroscopic probeand sample. In this work, we show that when the probe?sample distance is modulated with very low amplitude, thehigher the harmonic demodulation is, the better the ratiobetween the near-field signal and the interferometric backgroundresults. The choice of working at a given n harmonicis dictated by the experiment when the signal at the n+1harmonicgoes below the experimental noise. We demonstratethat the optical contrast comes from the nth derivative of thenear-field scattering, amplified by the interferometric background.By modelling the far and near field we calculate theprobe?sample approach curves, which fit very well the experimentalones. After taking a great amount of experimentaldata for different probes and samples, we conclude with a tableof the minimum enhancement factors needed to have opticalcontrast with field-enhanced scanning optical microscopy.","palabras_clave":"Enhancement factor|harmonic demodulation|scanning near-field optical microscopy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18051,"idioma_id":4,"titulo":"Effect of Ionization on the Behavior of n-Eicosane Phosphonic Acid Monolayers at the Air\/Water Interface. Experimental Determinations and Molecular Dynamics Simulations","resumen":"Monolayers of n-eicosanephosphonic acid, EPA, were studied using a Langmuir balance and a Brewster angle microscope at different subphase pH values to change the charge of the polar headgroups (Zav) from 0 to &#8722;2.  Molecular dynamics simulations (MDS) results for |Zav| = 0, 1, and 2 were compared with the experimental ones. EPA monolayers behave as mixtures of mutually miscible species (C20H41&#8722;PO3H2, C20H41&#8722;PO3H&#8722;, and C20H41&#8722;PO3  2&#8722;, depending on the subphase pH). The order and compactness of the monolayers decrease when increasing |Zav|, while go from strongly interconnected by phosphonic&#8722;phosphonic hydrogen bonds (|Zav| = 0&#8722;0.03) through an equilibrium between the total cohesive energy and the electrostatic repulsion between the charged polar groups (0.03 < |Zav| < 1.6) to an entirely ionic monolayer (|Zav| &#8776; 2). MDS reveal for |Zav| = 0 that the chains form spiralled nearly rounded structures induced by the hydrogenbonded network. When |Zav| &#8776; 1 fingering domains were identified. When Z &#8776; 2, the headgroups are more disordered and distanced, not only in the xy plane but also in the z direction, forming a rough layer and responding to compression with a large plateau in the isotherm. The monolayers collapse behavior is consistent with the structures and domains founds in the different ionization states and their consequent in-plane rigidity: there is a transition from a solid-like response at low pH subphases to a fluid-like response at high pH subphases. The film area in the close-packed state increases relatively slow when the polar  headgroups are able to form hydrogen bonds but increases to near twice that this value when |Zav| &#8776; 2. Other nanoscopic properties of monolayers were also determined by MDS. The computational results confirm the experimental findings and offer a nanoscopic perspective on the structure and interactions in the phosphonate monolayers.","palabras_clave":"Molecular Dynamics Simulations|Monolayers|Air\/Water Interface"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18052,"idioma_id":4,"titulo":"Quality preservation of organic cottage cheese using oregano essential oils","resumen":"Organic  cottage cheese was flavored with four different Argentinean oregano essential  oils (EOs) (Compacto, Cordobes, Criollo, and Mendocino) and thymol. Chemical  indicators of lipid oxidation, oxidation, and changes in the fatty acid and  organic acid profiles were determined during 30 days under thermal storage. The  samples flavored with Cordobes EO and thymol presented lower conjugated dienes (15.94 and 15.53, respectively), whereas the control sample  the maximum value (17.54Values of unsaturated fatty acids decreased significantly (p <  0.05) in cottage cheese samples because of oxidation deterioration. Samples  flavored with Compacto, Cordobes, and Criollo EOs showed lower saturated\/unsaturated  fatty acid ratios than the control (1.67, 1.62, and 1.68, respectively). Samples flavored with Cordobes and Compacto EOs significantly  reduced the production of organic acids during storage. The addition of oregano  essential oil in organic cottage cheese decrease the deterioration process of quality  parameter during storage prolonging its shelf-life","palabras_clave":"OREGANO|CHEESE|PRESERVING|ANTIOXIDANT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18053,"idioma_id":4,"titulo":"In Vitro age dependent response of macrophages to micro and nano titanium dioxide particles","resumen":"As a result of corrosion, microparticles (MP) and\/or  nanoparticles (NP) can be released from the metallic implants  surface into the bioenvironment. The biological response to  these particles depends not only on the physico-chemical  properties of the particles but also on host factors, such as  age. Macrophages have attracted wide concern in biomedicine.  The aim of this investigation was to study the age  related biological response of macrophages to TiO2-MP and  NP in vitro. Alveolar macrophages (AM) obtained from young  and senescent rats were cultured and exposed to TiO2-MP  and NP. Cell metabolism, superoxide anion (O2 2 ) and nitric  oxide (NO) generation, and cytokine release (IL-6, TNFa,  IL-10) were measured. Cell metabolism was not affected by  particle exposure. O2 2 and NO generation increased in a dose  dependent manner. A marked increase on IL-6 release was  found in the young-AM subpopulation exposed to TiO2-MP.  Conversely, both particle sizes induced a dose dependent  release of TNFa in senescent-AM. Only the highest concentration  of TiO2-particles caused a significant increase in IL-10  release in AM-cultures. These observations lend strong support  to the suggestion that cellular response of macrophages  to TiO2-particles is age dependent. The biological effect of  the particles would seem to be more deleterious in the senescent age-group.","palabras_clave":"MACROPAHGES|TITANIUM DIOXIDE|AGING|INFLAMMATORY MEDIATORS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18054,"idioma_id":4,"titulo":"Why the Co-based 115 compounds are different: The case study of GdMIn5 (M = Co,Rh,Ir)","resumen":"The discovery in 2001 of superconductivity in some heavy fermion compounds of the RMIn5 (R=4f or 5f elements; M=Co, Rh, Ir) family, has triggered an enormous amount of research into understanding the physical origin of superconductivity and its relation with magnetism. Although many properties have been clarified, there are still crucial questions that remain unanswered. One of these questions is the particular role of the transition metal in determining the value of critical superconducting temperature (TC). In this work, we analyze an interesting regularity that is experimentally observed in this family of compounds, where the lowest Néel temperatures are obtained in the Co-based materials. We focus our analysis on the GdMIn5 compounds and perform density-functional-theory-based total-energy calculations to obtain the parameters for the exchange coupling interactions between the magnetic moments located at the Gd3+ ions. Our calculations indicate that the ground state of the three compounds is a C-type antiferromagnet determined by the competition between the first- and second-neighbor exchange couplings inside GdIn3 planes and stabilized by the couplings across MIn2 planes. We then solve a model with these magnetic interactions using a mean-field approximation and quantum Monte Carlo simulations. The results obtained for the calculated Néel and Curie-Weiss temperatures, the specific heat, and the magnetic susceptibility are in very good agreement with the existent experimental data. Remarkably, we show that the first-neighbor interplane exchange coupling in the Co-based material is much smaller than in the Rh and Ir analogs which leads to a more two-dimensional magnetic behavior in the former. This result explains the observed lower Néel temperature in Co-115 systems and may shed light on the fact that the Co-based 115 superconductors present the highest TC.","palabras_clave":"MAGNETISM|115 COMPOUNDS|AB INITIO|QUANTUM MONTE CARLO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18055,"idioma_id":4,"titulo":"The adsorption of a mixture of particles with non-additive interactions: A Monte Carlo study","resumen":"The adsorption of binary mixtures with non-additive lateral interactions has been studied through grand canonical Monte Carlo simulations in the framework of the lattice-gas model. The traditional assumption of additive lateral interactions is replaced with a more general one including non-pairwise interactions. It is assumed that the energy linking a certain atom with any of its nearest neighbors strongly depends on the state of occupancy in the first coordination sphere of such an adatom. The process has been monitored through the adsorption isotherms and the differential heats of adsorption. Different combinations of both inter- and intra-species interactions have been considered in the analysis. Interesting behaviors were observed and discussed in terms of the low temperature phases formed in the system.","palabras_clave":"Adsorption|Binary mixtures|Non additive interactions|Monte Carlo simulations"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18056,"idioma_id":5,"titulo":"Modelo para Visualizar y Evaluar el Conocimiento Conceptual","resumen":"Este artículo describe un sistema computacional de evaluación del estudiante basado en el método DistSem.  El sistema de diagnóstico, Infosem, ha tomado como base el modelo de una red semántica. Los nodos de la red conforman los conceptos propuestos por el evaluador experto y los vínculos representan el grado de similitud que el estudiante atribuye a los dos conceptos que une cada vínculo. Uno de los aspectos relevantes del sistema es la interface visual la cual permite inspeccionar la red que representa el conocimiento conceptual. Se ha implementado una evaluación cualitativa y otra cuantitativa. La visualización permite al docente interpretar  fácilmente la respuesta de un estudiante. Se han realizado numerosas experiencias con estudiantes universitarios.","palabras_clave":"Evaluación basada en computadora|Visualización|Red semántica|Herramienta automática"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18057,"idioma_id":5,"titulo":"Efecto de soluciones de irrigación endodónticas sobre la resistencia a la flexión y el módulo de elasticidad de la dentina","resumen":"Introducción. Las soluciones de irrigación utilizadas en Endodoncia producen cambios estructurales en la dentina, afectando sus propiedades mecánicas. El Objetivo de este trabajo fue evaluar el efecto de soluciones de irrigación endodónticas, usadas solas y en forma consecutiva, sobre la resistencia a la flexión y módulo de elasticidad de la dentina radicular humana, ex vivo. Materiales y Métodos. Se emplearon 60 barras de dentina obtenidas a partir de premolares inferiores humanos unirradiculares, las cuales se dividieron al azar en 6 grupos (n=10), de acuerdo a la solución de irrigación a emplear: 1)- Agua destilada (control); 2)- Hipoclorito de sodio 1%; 3)- Ácido cítrico 1%; 4)- EDTA 17%; 5)- AC 1% + NaClO 1%; 6)- EDTA 17% + NaClO 1%. Luego de sumergirlas en las mismas durante 5 min a 37 °C, se realizó el test de tres puntos para determinar resistencia a la flexión y módulo de elasticidad. Los datos fueron analizados utilizando ANOVA y test de Tukey. Resultados. Las soluciones combinadas redujeron significativamente más la resistencia a la flexión de la dentina radicular respecto al resto, mientras que EDTA no mostró diferencias estadísticas respecto al control. Todas las soluciones analizadas disminuyeron el módulo de elasticidad de la dentina. Sin embargo, no se evidenció diferencias estadísticas entre las mismas. Conclusiones. A excepción de EDTA, todas las soluciones de irrigación analizadas redujeron la resistencia a la flexión de la dentina en 5 minutos de exposición. La combinación de un quelante seguida por NaClO aumentaría aún más este efecto.","palabras_clave":"DENTINA|IRRIGACIÓN|ENDODONCIA|RESISTENCIA A LA FLEXIÓN|MÓDULO DE ELASTICIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18058,"idioma_id":4,"titulo":"A non-linear logistic model describing the diameter kinetics of 'braeburn' apples, as a function of time from full bloom","resumen":"?Braeburn? apples (Malus ×domestica Borkh.) are grown throughout the warm regions of the world. They are bi-colored, crisp and very juicy; they store well and withstand the handling demands of international supply chains. The objective of this work was to develop a model to predict the seasonal growth for ?Braeburn? apples, expressed in terms of fruit diameter as a function of time from full bloom. Fruit growth was followed at the Experimental Farm of the Universidad Nacional del Comahue, High Valley region, Río Negro, Argentina (38°56?S, 67°59?W), located in an arid region with average annual rainfall of 250 mm, on a sandy loam soil. The study was conducted on ?Braeburn? apple trees trained to palmette leaders. The trees were spaced 4.0×2.3 m and row orientation was north-south. Trees were surface irrigated at weekly intervals to match the crop evapotranspiration requirements throughout the season. Five trees were selected at random and four fruits were sampled every two weeks till commercial harvest, during the 2005-06, 2006-07, 2007-08, 2008-09 and 2010-11 growing seasons. The range of sampling dates was 24 and 167 days after full bloom (DFB). Equations were developed with SYSTAT procedure. The R2 values and residual mean squares were used to evaluate the goodness-of-fit of the models. Results showed that the following logistic model provided the most satisfactory fit to the pooled data (n=1088), as compared to the power and linear equations: FD (mm) = 78.00\/(1+e1.5355-0.0258 DFB), R2=0.90, P<0.001. This model describes the fruit diameter obtainable in the specific orchard conditions for ?Braeburn? apple growth. Fruit maximal absolute growth rate derived from the selected function was 0.50 mm·day-1. A prediction chart was based on the development of the equation and showed ?Braeburn? apple sizes at various times after 167 DFB, with practical application to aid crop marketing.","palabras_clave":"MALUS ×DOMESTICA|DIAMETER|PREDICTION|SIGMOID CURVE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18059,"idioma_id":4,"titulo":"Influence of breeding season on fecal glucocorticoid levels in captive greater rhea (Rhea americana)","resumen":"Gender, hormonal and stress related changes can be seasonally influenced. We investigatewhether fecal glucocorticoid metabolite (FGM) levels can differ between male and femalecaptive Greater Rheas during breeding and non-breeding season. Over a 3-year-period, freshfecal samples from ten rheas (5 of each sex) were collected during breeding months (October,November and December) and non breeding months (April and June). A total of 960 sampleswere assayed using a commercial radioimmunoassay. Results showed that FGM levels wereaffected by the breeding season in a gender dependent way. Male rheas showed significantlyhigher FGM levels in the breeding months than in the non breeding months (13.44 ± 0.37 vs7.92 ± 0.1 ng\/g feces, respectively). In contrast, females did not show FGM seasonal changesthroughout the same sampling periods (7.55 ± 0.14 vs 7.26 ± 0.73 ng\/g feces). Moreover, during the breeding season months, males showed higher average FGM levels than their females counterparts (13.44 ± 0.37 vs 7.55 ± 0.14 ng\/g feces, respectively), and no differences were found between sexes during the non-breeding season (7.92 ± 0.1 vs 7.26 ± 0.73 ng\/g feces, respectively). Our findings suggest that male rheas have a sensitive adrenocortical response to breeding season related changes, probably due to the increased testosterone levels and agonist interactions that are also observed during that phase. Studies aimed to determine the appropriate sex ratio for captive rearing should be carefully considered, to help minimize male agonist encounters and thus to improve welfare of the group.","palabras_clave":"Ratite|Adrenocortical reponse|Non-invasive monitoring|Captivity|Welfare"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18060,"idioma_id":4,"titulo":"Trace metal behavior along fluvio-marine gradients in the Samborombon Bay, outer Rio de la Plata estuary,Argentina.","resumen":"Water and sediment samples were collected in the Samborombón Bay, outer Río de la Plata estuary to evaluate the dynamics of trace metals along the fluvial?marine transition. This estuarine environment presented strong salinity (0.11?31.4) and turbidity (21 to 4999 mgL-1) gradients with a consistent turbidity maximum zone (TMZ: 41 g suspended solids L-1) inthelowsalinityregion.Suspended particulate metals showed different spatial patterns: homogeneous distributions (Fe,Zn) and progressive enrichment from the TMZ to the maritime area (Cu,Ni). The influence of the TMZ is clearly reflected by the enrichment of flocculated clays which inturns control the distribution of sedimentary TOC and trace metals resulting in a prevailing decreasing land?sea gradient. Mn has a particular behavior along the salinity gradient denoting intense dissolved-particulated phase changes both in the water column and bottom sediments. An average 36% drop of particulate Mn observed in parallel with a strong dissolved peak suggests a rapid Mn desorption\/dissolution in the water column whereas bottom sediments display an average 72% Mn enrichment in the TMZ relative to the riverine sector reflecting the diffusive escape from anoxic sediments and reprecipitation in oxic surface layers.","palabras_clave":"HEAVY METALS|SEDIMENTS|TURBIDITY MAXIMUM ZONE|SAMBOROMBON BAY|RÍO DE LA PLATA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18061,"idioma_id":4,"titulo":"Evaluation of an adsorption system to concentrate VOC in air streams prior to catalytic incineration","resumen":"Catalytic combustion isa well-developed process for the removal of volatile organic compounds (VOCs).In order to reduce both the amount of catalyst needed for incineration and thesurface area of recuperative heat exchangers, an evaluation of the use ofthermal swing adsorption as a previous step for VOC concentration is made. Anair stream containing ethyl acetate and ethanol (employed as solvents inprinting processes) has been taken as a case study. Based on thecharacteristics of the adsorption\/desorption system and the properties of thestream to be treated, a monolithic rotor concentrator with activated carbon asadsorbent material is adopted. Once the temperature of the inlet desorptionstream TD is chosen, the minimum possible desorption flow rate, and the amount of adsorbent material can be properlydefined according to the extent of the Mass Transfer Zone (MTZ) at the end ofthe adsorption stage. An approximate procedure to speed up the calculationsneeded for sizing the bed and predicting the operating variables is alsopresented. In the case studied here, the concentration of the VOC stream canreach 6 times that of the primary effluent when TD=200 °C is chosen.","palabras_clave":"VOC concentration, |thermal swing adsorption, |catalytic incineration, |rotor concentrator, |activated carbon"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18062,"idioma_id":4,"titulo":"Rotavirus seasonality in urban sewage from Argentina: effect of meteorological variables on the viral load and the genetic diversity","resumen":"In Argentina, the rotavirus disease exhibits seasonal variations, being most prevalent in the fall and winter months. To deepen the understanding of rotavirus seasonality in our community, the influence of meteorological factors on the rotavirus load and the genetic diversity in urban raw sewage from Córdoba city, Argentina were evaluated. Wastewater samples were collected monthly during a three-year study period and viral particles were concentrated by polyethylene glycol precipitation. RT-nested PCR was applied for rotavirus detection, and VP7\/VP4 characterization and real-time PCR for rotavirus quantification. Both molecular techniques showed relatively similar sensitivity rates and revealed rotavirus presence in urban wastewater in cold and warm seasons, indicating its circulation in the local community all year round. However, a slight trend for rotavirus circulation was noted by real-time PCR in the fall and winter seasons, showing a significantly higher peak of rotavirus concentration at mean temperatures lower than 18°C and also higher, although not statistically different during drier weather. VP7 and VP4 gene characterization showed that G1 and P[8] genotypes were dominant, and temporal variations in genotype distribution were not observed. Rotavirus spread is complex and our results point out that weather factors alone cannot explain the seasonal quantitative pattern of the rotavirus disease. Therefore, alternative transmission routes, changes in human behavior and susceptibility, and the stability and survivability of the virus might all together contribute to the seasonality of rotavirus. The results obtained here provide evidence regarding the dynamics of rotavirus circulation and maintenance in Argentina.","palabras_clave":"Environmental monitoring; |Rotavirus; Seasonality"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18064,"idioma_id":4,"titulo":"PdCuAu ternary alloy membranes: hydrogen permeation properties in the presence of H2S","resumen":"PdCuAu ternary alloy membranes withdifferent component compositions were synthesized by sequential electroless depositionon top of porous stainless steel substrates.&nbsp;The ternary with the highest Au content, Pd69Cu14Au17,exhibited the highest hydrogen permeation flux, comparable to that of a Pd91Au9 membrane.&nbsp; Upon exposure to 100 ppm H2S\/H2at 400°C for 24 h, all PdCuAu membranes experienced flux reductions of ~ 55 %,followed by recovery to ~ 80% of the initial hydrogen flux upon reintroductionof pure hydrogen at 400°C.&nbsp; Complete fluxrecovery after H2S exposure required hydrogen treatment at 500°C.&nbsp; XRD analysis of the H2S-exposed PdCuAumembranes revealed fcc alloy structure with no evidence of bulk sulphideformation.&nbsp; In agreement with the XRD results, sulfur was notdetected in the bulk of H2S-exposed samples by EDS.&nbsp; However, analysisof H2S-exposed PdCuAu alloys by XPS-depth profiling revealed low,but measureable, amounts of sulfur in the near-surface region, about 10 nm indepth.&nbsp; The depth profiles of samplesafter hydrogen recovery treatment showed significantly reduced sulfur content.&nbsp; These results indicate that H2Sexposure causes flux loss in PdCuAu alloys through a surface-poisoningmechanism, and that the surface sulfide can be removed?and flux recovered?byhigh temperature treatment in H2.&nbsp;","palabras_clave":"PdCuAu MEMBRANE|HYDROGEN PURIFICATION |H2S resistance"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18065,"idioma_id":4,"titulo":"Electronic and magnetic properties of the Co2MnAl\/Au interface: relevance of the Heusler alloy termination","resumen":"We present ab initio calculations of electronic and magnetic properties of the ferromagnetic metal\/normal metal (F\/N) interface of the Heusler alloy Co2MnAl and gold. Two structural models are implemented: one with the ferromagnet slab terminated in a pure cobalt plane ('Co2-t'), and the other with it terminated with a plane of MnAl ('MnAl-t'). The relaxed optimum distance between the slabs is determined for the two models before densities of states, magnetic moments, and the electric potential are resolved and analysed layer by layer through the interface. Complementary, calculations for the free surfaces of gold and the Heusler alloy (for both models, Co2-t and MnAl-t) are performed for a better interpretation of the physics of the interface. We predict important  di&#64256;erences between the two models, suggesting that both terminations are to be expected to display sensibly di&#64256;erent spin injection performances.","palabras_clave":"HEUSLER ALLOYS|N\/F INTERFACES|SPINTRONICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18066,"idioma_id":4,"titulo":"Multiple responses optimization in the development of a headspace gas chromatography method for the determination of residual solvents in pharmaceuticals","resumen":"An efficient generic static headspace gas chromatography (HSGC) method was  developed, optimized and validated for the routine determination of several residual solvents (RS) in drug substance, using a strategy with two sets of calibration. Dimethylsulfoxide (DMSO) was selected as the sample diluent and internal standards were used to minimize signal variations due to the preparative step. A gas chromatograph from Agilent Model 6890 equipped with flame ionization detector (FID) and a DB?624 (30 m x 0.53 mm i.d., 3.00 µm film thickness) column was used. The inlet split ratio was 5:1. The influencing factors in the chromatographic separation of the analytes were determined through a fractional factorial experimental design. Significant variables: the initial temperature (IT), the final temperature (FT) of the oven and the carrier gas flow rate (F) were optimized using a central composite design. Response transformation and desirability function were applied to find out the optimal  combination of the chromatographic variables to achieve an adequate resolution of the analytes and short analysis time. These conditions were: 30ºC for IT, 158ºC for FT and 1.90 mL\/min for F. The method was proven to be accurate, linear in a wide range and very sensitive for the analyzed solvents, through a  comprehensive validation made according ICH guidelines.","palabras_clave":"RESIDUALS|SOLVENTS|PHARMACEUTICALS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18067,"idioma_id":4,"titulo":"ELECTROCHEMICAL BEHAVIOUR OF METHYLENE BLUE IN NON-AQUEOUS SOLVENTS","resumen":"The electrochemical behaviour of methylene blue in  solution of non-aqueous solvents with different supporting electrolytes was  studied. Dye electro-reduction generally presents two well-defined processes of  monoelectronic charge transfer. Solvent and supporting electrolyte have an  effect on the peak potentials and the peak current functions. The more cathodic  process is markedly affected by the cation of the supporting electrolyte, and  its peak potential changes with the acceptor number of the solvent. Different  current function values for the first cathodic process are attributed to the displacement of a dissociation equilibrium of the dye.  The electrochemical behaviour of the dye is modified in the presence of an acid  or a base. Spectrophotometric studies confirm the hypothesis of the reversible  equilibrium for the dissociation of the dye. In basic medium (added KOH or EDA  solutions), the formation of a stable radical was detected and characterized by  EPR spectroscopy.&nbsp; A general reaction  scheme is proposed. Selection of a suitable solvent\/supporting  electrolyte system is necessary to drive the electrochemical reaction by a  particular way. ","palabras_clave":"Cationic dye electro-reduction;|Cyclic voltammetry|ESR|Solvent effect;|Supporting electrolyte effect;|Reaction mechanism"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18068,"idioma_id":5,"titulo":"Acoustic Characteristics and Distortion of an Ionic Loudspeaker","resumen":"This paper presents some acoustic characteristics of a positive-corona-discharge loudspeaker, based on a parallel array of wires (corona electrode) and bars (collector electrode). The acoustic pressure is a combination of a monopolar and a dipolar term. The former arises from heat exchange in the wire surroundings and the latter stems from elastic collisions of drifting ions and neutral molecules in the gap between the electrodes. The relative contribution of both terms is studied. A differential circuit is devised to measure the AC ionic current in real time. This allows to relate it to the acoustic pressure and to compute the loudspeaker efficiency. Measurements on directivity and frequency response evidence that, even though the loudspeaker is a sum of discrete sources, it behaves as a rectangular diaphragm. This reduces the acoustical short-circuit and improves the transducer efficiency. Finally this work proposes a simple method to decrease the sound pressure harmonic distortion by applying a simple linearizing algorithm (based on the I-V discharge relationship) to the input signal.","palabras_clave":"ACÚSTICA|ELECTROACÚSTICA|DIRECTIVIDAD|EFICIENCIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18069,"idioma_id":4,"titulo":"PROMOTING MENTAL HEALTH AND COMMUNITY PARTICIPATION: A STUDY ON PARTICIPATORY ARTS PRACTICE, CREATIVITY AND PLAY IN THE CITY OF BUENOS AIRES, ARGENTINA","resumen":"    Abstract    The purpose  of this paper is to describe and analyze a participative health experience  involving art, creativity and play, in articulation with the strategy of  Comprehensive Primary Health Care focused on mental health. This experience is  conducted by a network of institutions in Buenos Aires City.    This is an  exploratory and descriptive case study based on qualitative research  methodologies. From an ethnographic perspective, the fieldwork revolved around  interviews and participant observation records. The systematization process  followed qualitative analysis content techniques. The outcomes describe a  practice cored in intersectoral work, community participation, occupation of  public space, creation of community gathering spaces and conformation of  solidarity ties for addressing complex psychosocial issues. The main  participatory processes focused on community organization and collective  artistic creations are described. It is concluded that such experiences  evidence substantial transformative potential, creating community conditions  suitable for joint decision-making within the health- illness care process  itself.  ","palabras_clave":"MENTAL HEALTH|HEALTH PROMOTION|COMMUNITY PARTICIPATION|COMMUNIITY ARTS|SOCIAL TRANSFORMATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18070,"idioma_id":4,"titulo":"The extremely populated globular cluster system of the lenticular galaxy NGC 6861","resumen":"We present a photometric study of the globular cluster (GC) system  associated with the lenticular galaxy (S0) NGC 6861, which is located in  a relatively low density environment. It is based on Gemini\/GMOS images  in the filters g´, r´, i´ of three fields, obtained under good seeing  conditions. Analysing the colour-magnitude and colour-colour diagrams,  we find a large number of GC candidates, which extend out to 100 kpc,  and we estimate a total population of 3000 ± 300 GCs. Besides the  well-known blue and red subpopulations, the colour distribution shows  signs of the possible existence of a third subpopulation with  intermediate colours. This could be interpreted as evidence of a past  interaction or fusion event. Other signs of interactions presented by  the galaxy are the non-concentric isophotes and the asymmetric spatial  distribution of GC candidates with colours (g´ - i´)0 &gt;  1.16. As observed in other galaxies, the red GCs show a steeper radial  distribution than the blue GCs. In addition, the spatial distribution of  these candidates exhibits strong signs of elongation. This feature is  also detected in the intermediate subpopulation. On the other hand, the  blue candidates show an excellent agreement with the X-ray surface  brightness profile, outside 10 kpc. They also show a colour-luminosity  relation (blue tilt), similar to that observed in other galaxies. A new  distance modulus has been estimated through the blue subpopulation,  which is in good agreement with the previous value obtained through the  surface brightness fluctuation method. The specific frequency of NGC  6861 (S N = 10.6 ± 2.1) is probably one of the highest  values obtained for an S0 galaxy so far.","palabras_clave":"galaxies|elliptical and lenticular galaxies|star clusters"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18071,"idioma_id":4,"titulo":"Shotgun proteome analysis of Bordetella pertussis reveals a distinct influence of iron availability on the bacterial metabolism, virulence, and defense response","resumen":"One of the mechanisms involved in host immunity is the limitation of iron accessibility to pathogens, which in turn provokes the corresponding physiological adaptation of pathogens. This study reports a gel-free nanoLC-MS\/MS-based comparative proteome analysis of Bordetella pertussis grown under iron-excess and iron-depleted conditions. Of the 926 proteins covered 98 displayed a shift in their abundance in response  7 to low iron availability. Forty-seven of them were found to be increased in level while 58 were found with decreased protein levels under iron starvation. In addition to proteins previously reported to be influenced by iron in B. pertussis, we observed changes in metabolic proteins involved in fatty acid utilization and poly-hydroxybutyrate production. Additionally, many bacterial virulence factors regulated by the BvgAS two-component system were found at decreased levels in response to iron limitation. These results, together with the increased production of proteins potentially involved in oxidative stress resistance, seem to indicate that iron starvation provokes changes in B. pertussis phenotype that might shape host-pathogen interaction.Para acceder al Supplemetal materia ir a:http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/pmic.201400512\/full","palabras_clave":"Bordetella pertussis|iron starvation|oxidative stress response|fatty acid degradation|virulence factors expression"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18073,"idioma_id":5,"titulo":"Composición botánica de la dieta del guanaco (Lama guanicoe) en la Reserva Corazón de la Isla, Tierra del Fuego (Argentina): utilización estacional de Nothofagus spp","resumen":"El guanaco (Lama guanicoe) representa una de las especies más características de la fauna de Tierra del Fuego En bosques ecotonalesse ha documentado el daño producido por el guanaco en la regeneración de la Nothofagus pumilio (lenga). Los objetivos del trabajofueron determinar la composición botánica de la dieta anual del guanaco en un área de bosque que incluye un sector de humedalesy estimar presencia estacional de Nothofagus spp. en la dieta. La dieta se evaluó mediante el método microhistológico de heces. Laproporción de especies consumidas por el guanaco presenta diferencias significativas entre los distintos meses del año. Las gramíneasy graminoideas representan el 52 % de la dieta anual. Festuca spp., Poa spp., Uncinia lechleriana y Carex spp., son dentro de susrespectivos grupos los géneros más consumidos por el guanaco. La presencia de Nothofagus spp. es constante y abundante durantetodo el año y representa el 29 % de la dieta anual. La consideración de tejidos no epidérmicos es fundamental para identificarNothofagus spp. en la dieta del guanaco en Tierra del Fuego. El guanaco consume ramas jóvenes de renovales de Nothofagus spp. conpresencia de hojas o yemas en las diferentes épocas del año. El importante consumo de renovales de Nothofagus spp. podría afectarnegativamente el desarrollo de la regeneración de estos bosques, por lo cual consideramos que este aspecto debe ser tenido en cuentaen la planificación y ejecución de actividades forestales y ganaderas en el bosque.","palabras_clave":"MICROHISTOLOGÍA|DIETA|RENOVALES|TEJIDOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18074,"idioma_id":4,"titulo":"Freezing avoidance by supercooling in Olea europaea cultivars:  the role of  apoplastic water, solute content and cell wall rigidity","resumen":"          Plants can avoid freezing damage by  preventing extracellular ice formation below the equilibrium freezing temperature  (supercooling). We used Olea europaea cultivars to assess which traits  contribute to avoid ice nucleation at subzero temperatures. Seasonal leaf water relations, non-structural carbohydrates, nitrogen and tissue damage and ice nucleation temperatures in different  plant parts were determined in five cultivars growing in the patagonian cold desert. Ice seeding in roots occurred at higher temperatures than in stems  and leaves. Leaves of  cold acclimated cultivars supercooled down to -13 ºC, substantially lower than  the minimum air temperatures observed in the study site. During winter, leaf ice  nucleation and leaf freezing damage (LT50) occurred at similar  temperatures, typical of plant tissues that supercool. Higher leaf density and  cell wall rigidity were observed during winter, consistent with a substantial  acclimation to sub-zero temperatures. Larger supercooling capacity and lower LT50  were observed in cold-acclimated cultivars with higher osmotically active solute  content, higher tissue elastic adjustments and lower apoplastic water. Irreversible  leaf damage was only observed in laboratory experiments at very low  temperatures, but not in the field. A comparative analysis of closely related  plants avoids phylogenetic independence bias in a comparative study of  adaptations to survive low temperatures.   ","palabras_clave":"FREEZING RESISTANCE|ICE NUCLEATION|OLIVE|LT 50"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18075,"idioma_id":4,"titulo":"White light from annealed porous silicon: broadband emission from violet to the near infrared","resumen":"We report white light emission under UV excitation from porous silicon (PS) samples annealed at different temperatures and surrounding atmospheres. The photoluminescence (PL) spectra show a broad emission from ultraviolet to near infrared. Annealed PS samples were studied by photoluminescence, FTIR and EPR spectroscopies. The PL spectra were found to include three main components centered at the violet, green and infrared. The FTIR experiments suggest the formation of a system composed by silicon nanocrystals embedded in a nonstoichiometric silicon oxide matrix (nc-Si\/SiOx). The EPR measurements reveal the existence of the well-know Pb0 (g~2.007) and Pb1 (g~2.004) centres, and of a signal at g~1.9997. The combined PL, FTIR and EPR results suggest that violet and green emissions come from oxygen-excess defects in SiOx while the infrared emission is related to defects located at Si\/SiOx interfaces.","palabras_clave":"Porous silicon|White photoluminescence|Silicon dioxide|Oxygen excess defects"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18076,"idioma_id":4,"titulo":"DNA synthesis in periportal and perivenous hepatocytes of intact and hepatectomized young mice","resumen":"ABSTRACT DNA synthesis of hepatocytes in two areas of Intact and Hepatectomized young mice liver along a circadian period was studied. DNA synthesis was significantly different at all analyzed time points in Intact and Hepatectomized animals. Differences between periportal and perivenous hepatocytes were found in hepatectomized animals at 04\/42 and 08\/46 hour of day\/hour post-hepatectomy. DNAs peak in periportal hepatocytes regenerating liver occurs 4 h earlier than in perivenous hepatocytes, probably reflecting their shorter G1 phase. Besides, daily mean values of regenerating livers were higher than those observed in Intact animals, as a consequence of surgical removal.","palabras_clave":"mouse|liver regeneration|lobule|zonation|bromodeoxyuridine|circadian variations"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18077,"idioma_id":4,"titulo":"Study of MgH2 + NbF5 mixtures: formation of MgH2&#8722;xFx solid solutions and interaction with hydrogen","resumen":"A mixture of MgH2 and (7&nbsp;mol%) NbF5 has been mechanically milled under Ar atmosphere. The evolution of the materials has been studied by in situ   pressure monitoring, XRD, DSC, TG, TPD, SEM, and isothermal hydrogen   absorption and desorption in a volumetric device. During milling, H-rich and F-rich solid solutions MgH2&#8722;xFx and MgHyF2&#8722;y are produced. After 40&nbsp;h of milling both solutions merge into a single one with formula MgH1.60F0.40. This solid solution is stable under a thermal treatment of 90&nbsp;h at 300&nbsp;°C under 6000&nbsp;kPa of H2. Hydriding and dehydriding kinetics in the as-milled and cycled materials are considerably faster than in MgH2 milled without additive. Desorption temperature in DSC or TG is lowered 100&nbsp;°C, and the material modified with NbF5 can be hydrided in less than 4&nbsp;min at T&nbsp;=&nbsp;250&nbsp;°C. A H-rich   solution is formed upon rehydriding the material, showing the   reversibility of the process. The kinetic improvement seems to be due to   a cooperative effect between MgHyF2&#8722;y and niobium hydride, the former providing seeding crystals for MgH2 nucleation, and the latter working as a gateway for hydrogen transfer.","palabras_clave":"Hydrogen storage|Niobium fluoride|Magnesium hydride|Mechanical alloying"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18078,"idioma_id":4,"titulo":"Trypanosoma cruzi trans-sialidase prevents Th1 elicitation via interleukin 10 and downregulates Th1 effector cells","resumen":"Pablo Ruiz Díaz y Juan Mucci co-primeros autores. Juan Mucci y Oscar Campetella  corresponding authors.    The trans-sialidases (TSs) from Trypanosoma cruzi, the agent of Chagas disease, are virulence factors shed to the bloodstream that induces strong alterations in the immune system. Here we report that enzymatically active TS (aTS) or its lectin-like isoform (iTS) disturb CD4 T cell physiology inducing downregulation of Th1 cell functionality and in vivo cell-expansion. By using ovalbumin-specific DO11.10 cells as tracers of Th1-phenotype developing clones, we found that the infection induced significant amounts of IFN-&#947; but low IL-2 and increased IL-4 production in vivo, in agreement with a mixed T helper response. Production of cytokines associated with Th2-phenotype was prevented by passive transference of TS-neutralizing antibodies. TSs also reduced the T cell receptor signaling, assayed by Zap-70 phosphorylation. TSs also reduced IL-2 and IFN-&#947; secretion with a concomitant increased IL-4 production, then unbalancing the CD4 T cell response towards the Th2 phenotype. This effect was prevented with IL-10-neutralizing antibodies or by using IL10-\/- antigen-presenting cells, supporting the subversion of this regulatory pathway. In support, TSs stimulated IL-10 secretion by antigen-presenting cells during their interaction with CD4 T cells. When polarized cells were stimulated in the presence of TSs, secretion of IL-2 and IFN-&#947; was strongly downregulated in Th1 while IL-2 production was upregulated in Th2 cells. Although Th1 response is associated with host survival, it may simultaneously induce extensive damage to infected tissues. Thus, by delaying the elicitation of Th1-response and limit its effector properties, TSs restrain cell response supporting T. cruzi colonization and persistence while favoring host survival.","palabras_clave":"TRYPANOSOMA CRUZI|TRANS-SIALIDASE|CD4 T CELLS|TH1\/TH2"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18079,"idioma_id":5,"titulo":"Falsa Adenitis equina: aislamiento de Streptococcus equi subsp. zooepidemicus  de caballos con linfoadenitis submandibular","resumen":"La Adenitis equina es una enfermedad infecciosa mundialmente distribuida y producida por Streptococcus equi subsp. equi  que afecta al tracto respiratorio superior de equinos jóvenes causando faringitis y linfoadenitis retrofaríngea y submandibular. Un cuadro conocido como Falsa Adenitis por su similitud clínica es ocasionado por Streptococcus equi subsp. zooepidemicus,  una bacteria grampositiva del grupo C de Lancefield y comensal de las mucosas del equino. Se trata de un patógeno oportunista que puede ocasionar enfermedad en el caballo y en otras especies animales, incluyendo el hombre.   El objetivo de este trabajo fue identificar Streptococcus equi subsp. zooepidemicus de equinos con linfoadenitis submandibular.   Se muestrearon 6 caballos con signología compatible con Adenitis equina mediante la punción de los linfonódulos submandibulares. Se identificó Streptococcus equi subsp. zooepidemicus y se determinó expresión capsular y el perfil de sensibilidad antibiótica.  Sólo un aislamiento expresó cápsula fina. Se evidenció un alto porcentaje de sensibilidad antibiótica, con sensibilidad intermedia a la tetraciclina y trimetroprim-sulfametoxazol y resistencia a la estreptomicina.  Al observar casos aislados con signología clínica leve podemos concluir que en los animales enfermos el agente actuó como patógeno oportunista luego de situaciones estresantes. Destacamos la importancia de la relación huésped ? agente ? ambiente para el desarrollo de enfermedad y el correcto diagnóstico microbiológico para un adecuado control y prevención de la Adenitis equina.","palabras_clave":"EQUINOS|ADENITIS EQUINA|FALSA ADENITIS|LINFOADENITIS|STREPTOCOCCUS EQUI SUBSP. ZOOEPIDEMICUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18080,"idioma_id":4,"titulo":"Molecular gas and star formation towards the IR dust bubble S24 and its environs","resumen":"&nbsp; {Using the APEX telescope, we mapped the molecular emission in the CO(2-1), $^{13}$CO(2-1),&nbsp; C$^{18}$O(2-1), and $^{13}$CO(3-2) lines in a region of about $5arcmin \times 5arcmin$ in size around the bubble. The cold dust distribution was analyzed using submillimeter continuum images from ATLASGAL and Herschel. Complementary IR and radio data at different wavelengths were used to complete the study of the interstellar medium in the region.}&nbsp; % results heading (mandatory)&nbsp;&nbsp; {The molecular gas distribution shows that gas linked to the S,24 bubble, G341.220-0.213, and G341.217-0.237 has velocities between --48.0 kms and --40.0 kms, compatible with a kinematical distance of 3.7 kpc generally adopted for the region. The gas distribution reveals a shell-like molecular structure of&nbsp; $sim$0.8 pc in radius bordering the S,24 bubble. A cold dust counterpart of the shell is&nbsp; detected&nbsp; in the LABOCA and Herschel-SPIRE images.&nbsp; The presence of weak extended emission at 24 $mu$m from warm dust&nbsp; and&nbsp; radio continuum emission projected inside the bubble indicates the existence of exciting sources and that the bubble is a compact hii region. Part of the molecular gas bordering the S,24 hii region coincides with the extended infrared dust cloud SDC341.194-0.221. A molecular and cold dust clump is present at the interfase between the S,24 hii region and G341.217-0.237, shapping the eastern border of the IR bubble. As regards G341.220-0.213, the presence of an arc-like molecular structure encircling the northern and eastern sections of this IR source indicates that G341.220-0.213 is&nbsp; interacting with the molecular gas. The analysis of the available IR point source catalogs reveals the existence of young stellar objects (YSO) candidates linked to the IR extended sources, thus confirming its nature as active star-forming regions.&nbsp; Gas and dust masses were estimated for the different features.The total gas mass in the region and the H$_2$ ambient density amount to 10300 msun and 5900 cmtres, indicating that guno, gdos, and the S,24 hii region are evolving in a high density medium. A triggering star formation scenario for the hii region is investigated. ","palabras_clave":"IR DUST BUBBLES|STAR FORMATION|MOLECULAR LINES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18081,"idioma_id":5,"titulo":"Modelizacion Mediante Software Computacionales de la Influencia de la Temperatura en el Comportamiento Reológico de un Alimento","resumen":"Se ha analizado la influencia que ejerce la temperatura en los parámetros reológigos de un aderezo con bajo contenido graso, saludable y sabroso para predecir como se ha de comportar el producto durante un procesamiento a utilizado escala industrial. Para la caracterización reológica se ha utilizado un viscosímetro rotacional y un baño termostatico sometido a las muestras a diferentes temperaturas y a un determinado ciclo de deformación. Las muestras mostraron un comportamiento de flujo No Newtoniano ajustándose a la Ley de la Potencia presentando un caracter pseudoplástico y tixotrópico.Tras el ajuste de las curvas de flujo los resultados revelaron que el indice de consistencia disminuyó con la temperatura aumentando el indice de comportamiento de flujo. El método matemático para realizar la identificación de los coeficientes que relacionan dichos indices con la temperatura se ha basado en la interpolación por Splines Cuadráticas resultando satisfactorio el modelo con los resultados experimentales obtenidos.","palabras_clave":"Aderezo|Temperatura|Reología"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18082,"idioma_id":5,"titulo":"Una propuesta metodológica para favorecer la interdisciplinariedad de contenidos científicos","resumen":"El objetivo de este trabajo es relatar la experiencia realizada por un equipo de profesores de la Facultad de Ciencias Exactas Físicas y Naturales de la Universidad Nacional de Córdoba. La innovación consiste en la incorporación de recursos materiales y metodologías con TIC en distintos talleres, seminarios y cursos para estudiantes y docentes de todos los niveles educativos: primarios, secundarios, terciarios y universitarios. Se utilizaron distintos sensores multiparamétricos, se adaptaron las metodologías y los elementos para facilitar la construcción de conocimientos científico-tecnológicos, y se generó y puso en marcha un aula virtual y un blog. La metodología elegida fue de corte constructivista basada en la resolución de situaciones problemáticas a través de experiencias de laboratorio a los fines de lograr la interdisciplinariedad de contenidos. La experiencia posibilitó el intercambio de conocimientos entre estudiantes y docentes de distintas instituciones y niveles educativos, enriqueciendo las vivencias, la reafirmación de hábitos, la expresión y  la comunicación.","palabras_clave":"TIC|SENSORES MULTIPARAMÉTRICOS|INTERDISCIPLINARIEDAD|INNOVACIÓN EDUCATIVA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18083,"idioma_id":4,"titulo":"Magnetised accretion discs in Kerr spacetimes","resumen":"Context. Observational data from X-ray binary systems provide strong evidence of astronomical objects that are too massive and  compact to be explained as neutron or hybrid stars. When these systems are in the thermal (high\/soft) state, they emit mainly in the  0.1-5 keV energy range. This emission can be explained by thin accretion discs that formed around compact objects like black holes.  The profile of the fluorescent iron line is useful to obtain insight into the nature of the compact object. General relativity does not  ensure that a black hole must form after the complete gravitational collapse of very massive stars, and other theoretical models such  as naked singularities cannot be discarded. The cosmic censorship conjecture was proposed by Penrose to avoid these possibilities  and is yet to be proven.  Aims. We study the effect caused by external magnetic fields on the observed thermal spectra and iron line profiles of thin accretion  discs formed around Kerr black holes and naked singularities. We aim to provide a tool that can be used to estimate the presence of magnetic fields in the neighbourhood of a compact object and to probe the cosmic censorship conjecture in these particular  astrophysical environments.  Methods. We developed a numerical scheme able to calculate thermal spectra of magnetised Page-Thorne accretion discs formed  around rotating black holes and naked singularities as seen by an arbitrary distant observer. We incorporated two different magnetic  field configurations: uniform and dipolar, using a perturbative scheme in the coupling constant between matter and magnetic field  strength. Under the same assumptions, we obtained observed synthetic line profiles of the 6.4 keV fluorescent iron line.  Results. We show that an external magnetic field produces potentially observable modifications on the thermal energy spectrum and  the fluorescent iron line profile. Thermal energy spectra of naked singularities are harder and brighter than those from black holes,  and in addition, peak and cut-off energies are affected by the external magnetic field. Moreover, iron line profiles of slowly rotating  black holes suffer more changes by a uniform magnetic field, while nearly extremal black holes and naked singularities are more  altered in the dipolar case. Based on our calculations, we discard the possibility of modelling the archetypal black-hole candidate in  Cygnus X-1 as a naked singularity.  Conclusions. Comparison of our models with observational data can be used to probe the cosmic censorship conjecture and to estimate the existence and global geometry of magnetic fields around compact objects by fitting the thermal energy spectra and iron line  profiles of X-ray binaries.","palabras_clave":"black hole physics|accretion, accretion disks|magnetic fields|line: profiles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18084,"idioma_id":4,"titulo":"A simple mechanism for the anti-glitch observed in AXP 1E 2259+586","resumen":"In this letter, we develop a simple internal mechanism that can account for the recent 'anti-glitch' observed for AXP 1E 2259+586 (|Delta u\/u| &gt; 10^(-7)). We propose that the cumulative decay of the internal toroidal magnetic field component will eventually become large enough to turn an originally stable prolate stellar configuration into an unstable one. The subsequent rearrangement of the stellar structure will result in a sudden spin-down of the whole star. We present order-of-magnitude calculations to give confidence to this scenario, using a simple, but physically reasonable, analytical stellar model. We estimate the energy released by the proposed mechanism and show that it is in agreement with the observations. Based on this model, we predict that to achieve the observed sudden spin-down, a minimum magnetar-like value for the magnetic field strength is needed. Consequently, we do not expect this kind of anti-glitch activity to occur in normal pulsars.","palabras_clave":"magnetic fields|stars: neutron|X-rays:individual: 1E 2259+586"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18085,"idioma_id":4,"titulo":"Mineralogical signature of hydrocarbon circulation in cretaceous red beds  of the Barda González area, Neuquen Basin, Argentina","resumen":"The Portezuelo Formation is part of a red bed sequence in the Neuquén Basin assigned to the Neuquén Group (lower Cenomanian?middle Campanian). In outcrops of the PortezueloFormation in the Barda González region, iron oxide and hydroxide cements are only preserved in the less permeable claystone layers. Paleomigration of hydrocarbons and formation waters along the most permeable layers bleached the rocks due to partialto total dissolution of cements and grains and formation of several authigenic minerals: (1) montmorillonite and pyrite in the medium- to fine-grained sandstones and mudstones, and (2) multistage calcite and pyrite in the coarse-grained sandstones and conglomerates.The &#948;34SCDT (Canyon Diablo troilite) of &#8722;24.4 to &#8722;60? values in pyrite point to microbial reduction of a sulfate precursor. The oxidation of hydrocarbons and fluctuations in pH and carbon dioxide pressure caused by organic acids resulted in multiple stages of dissolution and precipitation of calcite. Calcite crystals host hydrocarbon-bearing fluid inclusions (± pyrite) with variable fluorescence color, indicating that hydrocarbon composition changed with time. The intermediate &#948;13CPDB (Peedee belemnite) (&#8722;8.11? to &#8722;8.52?) and &#948;18OPDB(&#8722;9.76 to &#8722;9.83?) isotope composition of calcites may have resulted from mixtures of 13C-rich CO2 after the dissolution of local calcrete with 13C-poor CO2 from oxidizing hydrocarbons. This contribution provides for the first time key information to predict the distribution of authigenic minerals in reservoir rocks in the basin and improves understanding of the diagenetic history of the Portezuelo Formation.      ","palabras_clave":"HYDROCARBONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18086,"idioma_id":4,"titulo":"Percolation of binary mixtures adsorbed on square lattices","resumen":"In this paper, the adsorption of interacting binary mixtures on square lattices has been studied. By using Monte Carlo simulation and finite-size scaling analysis, the connection between the surface ordered phases and the percolating properties of the adsorbed phase has been investigated. A rich phase diagram separating a percolating from a nonpercolating region has been determined. The main features of the phase diagram have been discussed in terms of simple considerations related to the interactions present in the problem.","palabras_clave":"PERCOLATION|ADSORPTION|BINARY|MIXTURES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18087,"idioma_id":5,"titulo":"FORMULACION DE INSECTICIDA\/REPELENTE EN  LIPOGEL DE LARGA DURACION  PARA APLICACIÓN PREVENTIVA  VETERINARIA","resumen":"Formulación de un producto  farmacéutico  veterinario con efecto insecticida y repelente de efecto prolongado para aplicarse sobre el pelaje del animal. La formulación presenta interés para interrumpir el ciclo endémico zoonótico de enfermedades prevalentes vectorizada por flebótomos (leishmaniosis) .El vehículo en forma de gel adherente no lavable, compuesto por petrolato y aceite de soja desgomado, gelatinizado con polietileno de baja densidad en rangos de 1-2%, por un proceso de ?templado? por temperatura, el principio activo como repelente: se ha experimentado y propuesto el uso de entre 1-5 % de cipermetrina. Se han realizado trece lotes obteniéndose como mejor formulación la de 50% de petrolato, 50% de aceite de soja desgomado gelificado con PET (polietileno) 1% y BHT (butilhidroxitolueno) 1%. Presenta forma de gel traslucido adherente de olor sui generis leve. Se vehiculiza cipermetrina- acido 3-(2,2-Dicloroetil)-2,2-dimetilciclopropanocarboxilico ciano (3-fenoxifenil) metil ester) CAS 52315-07-8  al 2% por disolución simple","palabras_clave":"SPOT ON|LIPOGEL|LEISHMANIASIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18088,"idioma_id":4,"titulo":"Development and validation of a fungicide scoring system for management of late season soybean diseases in Argentina","resumen":"The use of foliar fungicides is a common disease control practice among soybean producers around the world, yet there is still no clear understanding about the timing and opportunity of fungicide applications to manage late season diseases (LSD) in soybean crops. The unnecessary use of fungicides in extended areas increases production costs, risk of resistance and risk of negative environmental impact. The objective of this study was to develop and validate a scoring system to guide the application of fungicides in soybean crops to manage LSDs in Argentina, with special reference to Septoria brown spot and Cercospora leaf blight. To develop the scoring system, a risk matrix with weighted epidemiological risk factors was developed based on previous research data. The scoring system recommends application of foliar fungicides based on the total points accumulated from the risk factors. Scoring greater than 33 indicates a higher probability of obtaining a positive yield response, whereas scoring below 23 indicates no expected response and thus no need for fungicide applications. Intermediate values indicate that the application of fungicides would produce uncertain results thus detailed analysis of risk factors would be required. To validate the scoring system, 19 field trials were carried out over five growing seasons in three Argentinian provinces. The fungicide used in all trials was a mixture of a quinone outside inhibitor and a demethylation inhibitor fungicide. In most cases, the scoring system resulted in appropriate decisions to apply the fungicide within the so-called ?window of opportunity?, which lies between the R3 and R5 soybean developmental stages. The greatest yield responses were achieved when the scoring system recommended the fungicide application at R3 or R4 or R5, depending on the obtained sum of points. In all cases, except when the scoring system recommended no application of the fungicide, disease severity values were significantly greater in untreated than in treated plants. Regarding net income, phenology-based applications showed negative margins in cases where the scoring system recommended no applications, demonstrating that in such situations the use of fungicide caused losses rather than yield advantages. In contrast, when the scoring system recommended the application of fungicide regardless of timing (R3, R4 or R5), net margins were always positive and generally provided a higher income. The scoring system presented in this study can be a valuable tool to reduce the number of fungicide applications in soybean crops, especially in seasons when conditions for LSD development are not favorable.","palabras_clave":"Septoria glycines|Cercospora kikuchii|late season soybean diseases|fungicide application timing|scoring system"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18089,"idioma_id":4,"titulo":"Back to the future: evidence of ancestral polymorphism in current populations of Anadenanthera colubrina var. cebil by means of Population Graphs","resumen":"Population Graphs includes network theory to infer the relationship among individuals or populations and their respective roles. The hypothesis for this work establishes that Argentinean natural populations of Anadenanthera colubrina var. cebil keep ancestral polymorphism as a consequence of continuous historical distribution of this species in South America. Network analyses were performed centered on individuals and populations using two different measures which integrate genetic information in terms of time and divergence history. These analyses allow us to conclude that the populations of A. colubrina var. cebil display geographical isolation even though they are historically related.","palabras_clave":"Anadenanthera colubrina var. cebil |ancestral polymorphisms|genetic structure|networks"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18090,"idioma_id":4,"titulo":"Intensity-symmetric Airy beams","resumen":"Theoretical, numerical, and experimental research on a novel family of Airy beams in rectangular coordinates having a symmetric transverse pattern of light intensity is presented. The intensity-symmetric Airy beams include both the symmetric Airy beam whose field amplitude is an even function of the transverse coordinates and the antisymmetric Airy beam whose field amplitude is an odd function of such coordinates. The theoretical foundations are based on the relationship of the symmetries of the spectral phase with the cosine and sine Fourier transforms. These beams are analyzed in a propagation range also including the region preceding the Fourier plane. These beams exhibit autofocusing, collapse, self-bending, and reversal propagation. Moreover, the intensitydistribution is strongly asymmetric with respect to the Fourier plane. All these peculiar features were not reported for other classes of paraxial beams in a rectangular frame. The experimental generation of intensity-symmetric Airy beams is demonstrated supporting the theoretical predictions. Possible applications in planar waveguide writing and optical trapping are also discussed.","palabras_clave":"laser beam shaping|Physical Optics|Paraxial wave optics|propagation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18091,"idioma_id":4,"titulo":"Children's  Gratitude: Implication of Contextual and Demographic Variables in Argentina","resumen":"Este artículo explora los motivos de agradecimiento que expresan los niños,teniendo en cuenta variables demográficas y contextuales. La muestra estuvo compuesta por 249participantes argentinos de 8 a 10 años de edad (127 niños de estrato socioeconómico medio -Grupo1-, y 122 de estrato socioeconómico bajo -Grupo 2). Se utilizó la técnica de respuestas libres y serealizaron pruebas V de Cramer para analizar si los motivos de gratitud se asociaban al estrato socioeconómico, al género y la edad. El Grupo 1 agradece principalmente por la familia, mientrasque el Grupo 2 se focaliza en los bienes materiales y elementos básicos para la supervivencia, comoel alimento. Las niñas agradecen mayormente por las relaciones afectivas. Los varones mencionanlos objetos materiales, los préstamos y la indulgencia parental. Los motivos de gratitud tambiénestuvieron significativamente asociados a la edad.socioeconómico, al género y la edad. El Grupo 1 agradece principalmente por la familia, mientrasque el Grupo 2 se focaliza en los bienes materiales y elementos básicos para la supervivencia, comoel alimento. Las niñas agradecen mayormente por las relaciones afectivas. Los varones mencionanlos objetos materiales, los préstamos y la indulgencia parental. Los motivos de gratitud tambiénestuvieron significativamente asociados a la edad.socioeconómico, al género y la edad. El Grupo 1 agradece principalmente por la familia, mientrasque el Grupo 2 se focaliza en los bienes materiales y elementos básicos para la supervivencia, comoel alimento. Las niñas agradecen mayormente por las relaciones afectivas. Los varones mencionanlos objetos materiales, los préstamos y la indulgencia parental. Los motivos de gratitud tambiénestuvieron significativamente asociados a la edad.socioeconómico, al género y la edad. El Grupo 1 agradece principalmente por la familia, mientrasque el Grupo 2 se focaliza en los bienes materiales y elementos básicos para la supervivencia, comoel alimento. Las niñas agradecen mayormente por las relaciones afectivas. Los varones mencionanlos objetos materiales, los préstamos y la indulgencia parental. Los motivos de gratitud tambiénestuvieron significativamente asociados a la edad.socioeconómico, al género y la edad. El Grupo 1 agradece principalmente por la familia, mientrasque el Grupo 2 se focaliza en los bienes materiales y elementos básicos para la supervivencia, comoel alimento. Las niñas agradecen mayormente por las relaciones afectivas. Los varones mencionanlos objetos materiales, los préstamos y la indulgencia parental. Los motivos de gratitud tambiénestuvieron significativamente asociados a la edad.","palabras_clave":"EMOCIONES|NIÑEZ|GÉNERO|EDAD - NIVEL SOCIOECONÓMICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18092,"idioma_id":5,"titulo":"Micobacterias ambientales: componentes estructurales y no estructurales que evidencian su potencial como patógenas oportunistas","resumen":"Las infecciones producidas por micobacterias ambientales (MA) han ido cambiando a través del tiempo. Históricamente la mayoría de dichas infecciones se manifestaban en individuos inmunocomprometidos o en personas de edad avanzada con alguna afección pulmonar predisponente. Posteriormente se identificaron como una complicación común de pacientes infectados con HIV. En la actualidad y en todo el mundo se registran casos en pacientes inmunocompetentes sin una aparente causa predisponente, relacionados en general a procedimientos quirúrgicos o estéticos. Además, junto con el aumento en la frecuencia de aislamientos de MA, se van describiendo nuevas especies susceptibles de producir patología en humanos. Las micobaterias pueden ser agrupadas de acuerdo a su nivel de virulencia o significancia clínica. Algunas especies son consideradas de transición entre patógenas y saprófitas, definidas como patógenas oportunistas. No está claro qué particularidad lleva a que una MA saprófita pueda transformarse en patógena y a su vez que desencadene infección en huéspedes inmunocompetentes. En esta revisión se describen los componentes estructurales y no estructurales considerados posibles factores de patogenicidad más relevantes de las MA, que intervienen mayoritariamente en la interacción microorganismo-célula fagocítica.  También se hace referencia a nuevos descubrimientos in vitro dentro de la patogenia del género Mycobacterium, que tratan de elucidar diferencias y similitudes con las micobacterias patógenas obligadas, más específicamente con M .tuberculosis.","palabras_clave":"MICOBACTERIAS|AMBIENTALES|FACTORES |PATOGENICIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18093,"idioma_id":5,"titulo":"Fertilización balanceada de arroz en Entre Ríos","resumen":"Sustentados en la necesidad de realizar nuevas experiencias de fertilización, en base a los elementos que se han detectado como deficientes o restrictivos para el arroz en Entre Ríos; se realizaron ensayos con el objetivo de evaluar el efecto de la fertilización con N, P, K y Zn, sobre el rendimiento del cultivo de arroz. El cultivo de arroz en Entre Ríos presenta una deficiencia de N generalizada, debido a que los suelos no pueden liberar suficiente cantidad para sostener altos rendimientos, por lo cual la respuesta a la fertilización nitrogenada es muy significativa y se recomienda su aplicación en todos los casos. Si bien los suelos de Entre Ríos son genéticamente deficientes en P para los cultivos de secano, frecuentemente la liberación de P en condiciones de anaerobiosis es suficiente para cubrir los requerimientos del cultivo de arroz. Las respuestas a la fertilización con P se verifican únicamente en suelos con pH neutro a ligeramente alcalino. La disponibilidad de K en los suelos de Entre Ríos es media a alta. Sin embargo, la respuesta a su aplicación en arroz es significativa. Más aún, cuando la proporción de Ca en el complejo de cambio es elevada y se verifica un pH neutro a alcalino, por lo cual en estas condiciones se aconseja la fertilización potásica. En el caso del Zn, su disponibilidad en el suelo es baja, la respuesta es frecuente y cobra magnitud importante en suelos de pH 7 o superior. Se recomienda la incorporación de este micronutriente en los programas de fertilización de manera generalizada.","palabras_clave":"ARROZ|FERTILIZACIÓN|NITRÓGENO|FÓSFORO|POTASIO|CINC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18094,"idioma_id":4,"titulo":"Iron and manganese content in groundwater on the northeastern coast of the Buenos Aires Province, Argentina","resumen":"The iron and manganese content in groundwater on the northeastern coast of the Buenos Aires Province, Argentina, was analyzed. Borehole sampling and chemical analyses were performed and evaluated based on the hydrogeological characteristics of the phreatic aquifer located in the coastal barrier, which is the only supply source to the population. Fe concentrations in groundwater fluctuate between 0.03 and 3.5 mg\/L, with a mean value of 0.33 mg\/L, whereas Mn varies between 0.03 and 1.20 mg\/L, with a mean value of 0.24 mg\/L. There is a relationship between the geomorphological environments and the distribution of major ions, except the case of Fe and Mn. The sand that constitutes the aquifer contains pyroxenes, amphiboles, biotite, Fe oxides and hydroxides, and volcanic groundmass stained by hydroxides, all of which are the source of Fe and Mn?whose concentrations are unrelated to each other, to Ph or to Eh due to a state of redox disequilibrium.  Possible health risks due to Fe and Mn excess in water are considered. According to the international guidelines for Fe, 38% of the samples exceed the acceptable values, while 33% exceed the Argentine standards. As regards Mn, the samples with excess Mn are 53% and 38%, respectively. Further groundwater quality monitoring and chemical studies are necessary, especially regarding the evolution of Fe and Mn contents. In order to offer an adequate supply of drinking water to the population, it is necessary to remove Fe and Mn so that the concentrations are within the drinking water guidelines.","palabras_clave":"DRINKING WATER|IRON |MANGANESE|COASTAL AQUFER|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18095,"idioma_id":4,"titulo":"Adsorption of Aromatics from Base Oil over Polymeric Resins.  Equilibrium and kinetics.","resumen":"Adsorption of aromatic molecules from base oil over an acid resin (Amberlyst15w) was studied, with a focus on reducing the aromatic content to that of a white mineral oil.  It was found that the adsorption capacity of the resin was low. At saturation in the best condition the adsorption capacity corresponded to 10% de acid capacity. The effects of dilution, temperature and adsorption time were studied.In the absence of a diluting solvent the isotherm was unfavorable and the adsorption rate was low with a pseudo first order constant of about 0.1 h-1. Dilution of the oil with n-hexane had beneficial effects on the adsorption capacity, the adsorption rate and the yield of refined oil.  The 1:1 vol:vol dilution was found to be optimal. Kinetic data were better explained by a model of dominant intraparticle diffusion, the adsorbate load being proportional to the square of the adsorption time. Dilution with n-hexane was thought to decrease the viscosity with a proportional increase of the diffusivity, and a decrease of the chemical affinity of the oil matrix.Estimations of the oil purity and refined oil yield after a series of equilibrium stages  indicated that 3 stages with an adsorbent-to-oil ratio of 0.5 (g g-1) and a 1:1 dilution in n-hexane could refine the studied base oil (initial aromatics content 0.136 mmol g-1) to a white mineral oil of food grade, with a yield of about 60%. Removal of the solvent was considered easy given the high volatility of n-hexane as compared to the oil.","palabras_clave":"base oil|white mineral oil|adsorption"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18096,"idioma_id":5,"titulo":"La institucionalización mercantilizada del creer en la era de la individualización de lo social","resumen":"Este libro es un libro novedoso en el marco de los estudios sobre industrias culturales, si pensamos en la articulación con  estudios de género,  juventud, grupos migrantes, pero nada había aparecido entre nosotros sobre industrias culturales y religión. Ya casi no hay un aspecto de la cultura que no pase el cedazo de la industria cultural como ya analizaban apocalípticamente Adorno y Horkheimer (1987).    Se trata de un libro necesario que marca un antes y un después en el campo, cada vez más vasto de estudios sobre industrias culturales.   Probablemente se haya pensado o imaginado que la religión o mejor dicho los estudios sociales sobre religión nada tendrían que ver con esta dimensión cultural imaginada y pensada en el marco de las formas del arte con la reproducción técnica en el capitalismo tardío.  Si en Adorno, el concepto estaba asociado a la colonización del arte por el mercado y en consecuencia a la desaparición de la capacidad del hombre de pensar en forma autónoma, ideal de la modernidad iluminista, en Benjamín, el concepto estaba más asociado a la posibilidad de liberación social y transformación radical de la sociedad por la celebración de la técnica la cual habilitaba el desprendimiento del arte de su forma aurática.","palabras_clave":"industria cultural|creencias|imaginarios sociales|teoria sociologica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18097,"idioma_id":4,"titulo":"Subtle Structural Aspects of Propylene-based Copolymers as Revealed by Raman Spectroscopy","resumen":"Raman spectroscopy is used to elucidate fine details of the rather complex microstructure of ethylene-propylene copolymers (EPCs). This paper is focused on a series of commercial EPCs (Versify by Dow) with well-characterized ethylene content. Particular emphasisis given on the analysis of crystal type and content and their relation with EPC chain microstructure. Information provided by Raman is compared with that obtained by differential scanning calorimetry (DSC), a well-established technique widely used in thepolymer field. Temperature-resolved Raman experiments are also carried out to interpret more precisely the complex melting patterns observed in the DSC traces. These experiments reveal with more detail the crystal chemical composition and melting temperatureranges of EPC samples, key features to design processing conditions that guarantee optimum lifetime and recyclability of overmolded parts.","palabras_clave":"Raman Spectroscopy|Ethylene-propylene copolymers|crystallinity|microstructure"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18098,"idioma_id":4,"titulo":"PREGNANT WOMEN INFECTED WITH PANDEMIC INFLUENZA A(H1N1)pdm09 VIRUS SHOWED DIFFERENTIAL IMMUNE RESPONSE CORRELATED WITH DISEASE SEVERITY","resumen":"Background: During pregnancy, immunological and hormonal alterations place women at increased risk for influenza-related severe illnesses including hospitalization and death. Although A(H1N1)pdm09 infection resulted in increased disease severity in pregnant women, the precise mechanisms responsible for this risk have yet to be established. Objectives: The present study was aimed to investigate the role of host chemokines and cytokine profiles in A(H1N1)pdm09 infection regarding disease severity in pregnant women. Study design: This retrospective survey examined 41 pregnant women with confirmed A(H1N1)pdm09 infection. Of them, 12 died (D), 29 survived (S), and 17 remained uninfected and served as controls (C). Antiviral response was evaluated for IFN-&#946; expression and gene expression profiles of cytokines (TNF-&#945;, IL-6, IL-12, TGF-&#946;) and chemokines (IL-8, RANTES, MCP-1, IP-10), and the viral Matrix (M1) gene was quantified and normalized using the housekeeping gene product &#946;-actin mRNA. Results: Higher IL-8 and TNF-&#945; mRNA expression were found in D and S compared with C, while IL-6 showed higher expression in D. Interestingly, these results were associated with a decrease in the anti-inflammatory response of TGF-&#946; mRNA and IFN-&#946;. These alterations would lead to an imbalance in the immune response of those patients. Conclusions: Pregnancy-related reductions in IFN-&#946; and TGF-&#946; expression levels and elevated levels of pro-inflammatory cytokines could explain the increased severity of infection and death of pregnant women. These findings may help improve the understanding of the high susceptibility and disease severity to influenza virus infection during pregnancy.","palabras_clave":"INFLUENZA|EMBARAZO|CITOQUINAS|INTERFERON"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18099,"idioma_id":4,"titulo":"Evaluation and Validation of a Semiautomatic Image Analysis Method: Quantification of Nares Cell Proliferation of Rhinella arenarum (Anura) Detected with the Avidin-Biotin Complex\/Peroxidase, DAB.","resumen":"he current report presents the development and application of a novel methodological approach for computer-based methods of processing and analysis of proliferative tissues labeled by ABC-peroxidase method using 3,3 -diaminobenzidine (DAB) as chromogen. his semiautomatic method is proposed to replace the classical manual approach, widely accepted as gold standard. Our method is based on a visual analysis of the microscopy image features from which a computational model is built to generate synthetic images which are used to evaluate and validate the methods of image processing and analysis. he evaluational lows knowing whether the computational methods applied are afected by the change of the image characteristics. Validational lows determining the method?s reliability and analyzing the concordance between the proposed method and a gold standar done. Additional strongness of this new approach is that it may be a framework adaptable to other studies made on any kind of microscopy.","palabras_clave":"QUANTIFICATION|CELL PROLIFERATION|AVIDIN BIOTIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18100,"idioma_id":4,"titulo":"Growth and oxidative enzymatic activity of in-vitro cultures of Ciliochorella buxifolia","resumen":"To get a better insight into the physiological capabilities of Ciliochorella buxifolia, the most frequent fungus occurring on Scutia buxifolia leaf-litter in a native forest from Argentina, its in-vitro ability to use 10 carbon sources and to produce extracellular enzymes, including its response to tannic acid and to the addition of a water-soluble fraction of Scutia buxifolia leaf-litter, was analyzed. Growth, colony morphology and extracellular enzyme activity as well as differentiation of pycnidia were a function of the C substrate. The fungus responded to the presence of tannic acid in a range between 0.001 and 0.1% (w\/v), by increasing growth, but higher phenol concentrations like 0.5% were inhibitory. The activity of extracellular oxidative enzymes increased with the concentration of tannic acid. Furthermore, the fungus showed extracellular laccase and peroxidase activity, being the former increased by water-soluble fraction in association to pycnidia development. Based on these results, Ciliochorella buxifolia is a fungus growing on Scutia buxifolia leaf-litter that is able to metabolize soluble phenolic compounds, which triggers the synthesis of extracellular oxidative enzymes possibly involved in sporulation and detoxification reactions","palabras_clave":"Argentina|Extracellular enzymes|Forest|Laccase|Peroxidase"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18101,"idioma_id":4,"titulo":"Reproductive behaviour of three species of freshwater crabs of the family Trichodactylidae (Crustacea: Decapoda) including forced copulation by males","resumen":"This report includes a detailed description of the reproductive behaviour of  the freshwater crab Zilchiopsis collastinensis in the family Trichodactylidae  and some observations on two other genera. It presents observations on the  courtship, copulation, spawning, incubation and maternal care in Z. collastinensis. No discernible courtship behaviour occurred. We found instead that forced copulation is practised by males. Z. collastinensis copulations were  observed in between April and October, for Dilocarcinus pagei between January  and August, and throughout the year for Trichodactylus borellianus. The  spawning behaviour of all of the species observed took place out of the water.  Incubation lasted between 46 and 62 days in D. pagei, 37 and 41 days in Z.  collastinensis and 8 and 12 days in T. borellianus. The number of juveniles  carried by each ovigerous female ranged from 651 ± 172 in Z. collastinensis,  through 582 ± 8 in D. pagei to 63 ± 33 in T. borellianus. The results support  the proposition that members of the family Trichodactylidae, comprising  exclusively endemic freshwater crabs, have evolved unusual adaptive reproductive  behaviours to optimize their reproductive fitness in unstable environments.","palabras_clave":"courtship;|mating; |maternal care; |forced copulation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18102,"idioma_id":4,"titulo":"Nanocrystal-reinforced soy protein films and their application as active packaging","resumen":"Soy protein isolate (SPI) films reinforced with starch nanocrystals (SNC) were developed by simple casting method. The films were transparent and homogeneous. The opacity and degree of crystallinity increased with the amount of nanocrystals. Moisture content, total soluble matter and Swelling in water were evaluated, showing a marked effect on SNC Additions. As the amount of SNC increased, the films exhibited lower affinity for water. Moreover, mechanical properties were determined showing that SPISNC reinforced films became more resistant and less elongable as SNC amount increased. With the incorporation of a considerable amount of reinforcements, a marked variation was observed in these properties. In addition, assays performed demonstrated that b-Cyclodextrins (b-CD)-containing SPI-SNC films were able to sequester cholesterol when brought into contact with cholesterol rich food such as  milk. This effect was more marked as the amount of b-CD into the films increased. The methodologies developed in this work allowed yielding biodegradable films with optimized physical and mechanical properties which were assayed as active food coating.","palabras_clave":"Soy protein |Nanocrystals Films |Cholesterol |Active packaging"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18103,"idioma_id":4,"titulo":"Preliminar data on growth and enzyme abilities of soil fungus Humicolopsis cephalosporioides under different incubation temperatures","resumen":"Nothofagus pumilio (Poepp &amp; Endl.) Krasser, known as ?lenga? is the most important timberwood species in southernmost Patagonia (Argentina). Humicolopsis cephalosporioides Cabral &amp; Marchandis a soil fungus associated with Nothofagus pumilio forests, which has outstanding cellulolytic activity.However, there is no information about the ability of this fungus to use organic substrates other thancellulose, and its ability to produce different enzyme systems, as well as its response to temperature.Aims: The aim of this study was to examine the role of H. cephalosporioides in degradation processes inN. pumilio forests in detail by evaluating the in vitro ability of four isolates of this fungus to grow andproduce different lytic enzyme systems, and their response to incubation temperature.Methods: The ability of the fungi to grow and produce enzyme systems was estimated by inoculatingthem on agar media with specific substrates, and the cultures were incubated at three temperatures.Results: A differential behavior of each strain in levels of growth and enzyme activity was found accordingto the medium type and\/or incubation temperature.Conclusions: A intra-specific variability was found in H. cephalosporioides. Likewise a possible link betweenthe saprotrophic role of this fungus in N. pumilio forests and the degradation of organic matter under stressconditions, such as those from frosty environments, was also discussed.","palabras_clave":"extracellular enzyme|soil fungi"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18105,"idioma_id":5,"titulo":"VOLTZIALES Y PINALES (=CONIFERALES) DE LA FORMACIÓN CORTADERITA (TRIÁSICO MEDIO), ARGENTINA, Y SU IMPLICANCIA EN LA RECONSTRUCCIÓN DE LAS CONÍFERAS TRIÁSICAS","resumen":"En este trabajo se presenta el hallazgo de leños, hojas y ramas asignables a la Subclase Piniidae (Ordenes Voltziales y Pinales), provenientes de la Formación Cortaderita (Triásico Medio). Los materiales fueron recolectados en las quebradas de la Cortaderita y de la Tinta, en el área de Barreal de la cuenca de Barreal-Calingasta, precordillera sanjuanina, Argentina. Se reconocieron hojas correspondientes a tres especies del género Heidiphyllum (Orden Voltziales),  ramas foliosas asignadas a Elatocladus planus (Orden Pinales), y leños permineralizados designados como Cupressinoxylon zamunerae sp. nov. (Orden Pinales). Las últimas dos especies presentan características que permiten asignarlas a la Familia Cupressaceae sensu lato.A su vez, se demuestra aquí que corresponden a la misma entidad biológica, que toma el nombre de la nueva especie de Cupressinoxylon aquí descripta. Esta reconstrucción se basa en los criterios de soporte por afinidad y ocurrencia mutua, además de los morfológicos y anatómicos. De este modo, se interpreta que Cupressinoxylon zamunerae sp. nov. corresponde a una planta arbórea de aproximadamente 13 m de altura, muy ramificada, con ramas de anteúltimo orden con hojas escuamiformes y ramas de último orden alternas, con hojas sésiles, uninervias, lineares a aciculares distribuidas helicoidalmente. Estos registros confirman la presencia, en el Gondwana, de las Cupressaceae sensu lato, tempranamente, a partir del Triásico.","palabras_clave":"Barreal-Calingasta|Grupo Sorocayense|Voltziaceae|Cupressaceae sensu lato."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18106,"idioma_id":5,"titulo":"LAS COLECCIONES DE LA DIVISIÓN PALEOBOTÁNICA, FACULTAD DE","resumen":"El Museo de La Plata es parte de la  Facultad  de  Ciencias  Naturales  y Museo,  dependiente  de  la  Universidad Nacional de La Plata. Fue inaugurado en 1888.  Tiene  como  misión  específica resguardar  las  colecciones  biológicas, geológicas y antropológicas de Argentina, América  del  Sur  y  otros  lugares  del mundo,  y  difundirlas  a  través  de  la investigación,  exhibición  y  extensión educativa. La  institución  cuenta  con  un amplio abanico  de especialidades dentro de las ramas principales de investigación: Zoología,  Botánica,  Paleontología, Geología  y  Antropología.  Dentro  de  la línea  de  investigación  paleontológica,  se destacan  tres  divisiones:  Paleobotánica, Paleontología  Vertebrados  y Paleozoología de Invertebrados. La  Paleobotánica  estudia  las plantas  fósiles  y  comprende  aspectos descriptivos  (anatómico-morfológicos), sistemáticos  (clasificación),  taxonómicos (parentesco), fitogeográficos (distribución de  las  plantas),  ecológicos  (adaptación  al ambiente)  y  evolutivos.  La  Paleobotánica tiene como objetivo integrar a todos estos aspectos  reconstruyendo  la  historia  y evolución del reino vegetal. En  la  División  Paleobotánica  se resguardan  dos  colecciones.  Una  de megafósiles y otra de microfósiles, cortes y  tacos  de  Microscopio  Electrónico  de Barrido  (MEB);  ambas  cuentan  con  un importante número de ejemplares tipo. Estos  repositorios  tienen  un reconocimiento  a  nivel  nacional  e internacional,  y  albergan  materiales  y ejemplares  históricos  que  son consultados  por  investigadores nacionales y extranjeros.","palabras_clave":"Colecciones|Paleobotánica|División Paleobotánica|Historia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18107,"idioma_id":4,"titulo":"Dog's discrimination of Human Selfish and Generous Attitudes: The role of individual recognition, experience, and experimenters gender","resumen":"Discrimination of and memory for others? generous and selfish behaviors could be adaptive abilities in social animals. Dogs have seemingly expressed such skills in both direct and indirect interactions with humans. However, recent studies suggest that their capacity may rely on cues other than people?s individual characteristics, such as the place where the person stands. Thus, the conditions under which dogs recognize individual humans when solving cooperative tasks still remains unclear. With the aim of contributing to this problem, we made dogs interact with two human experimenters, one generous (pointed towards the food, gave ostensive cues, and allowed the dog to eat it) and the other selfish (pointed towards the food, but ate it before the dog could have it).Then subjects could choose between them (studies 1-3). In study 1, dogs took several training trials to learn the discrimination between the generous and the selfish experimenters when both were of the same gender. In study 2, the discrimination was learned faster when the experimenters were of different gender as evidenced both by dogs? latencies to approach the bowl in training trials as well as by their choices in preference tests. Nevertheless, dogs did not get confused by gender when the experimenters were changed in between the training and the choice phase in study 3. We conclude that dogs spontaneously used human gender as a cue to discriminate between more and less cooperative experimenters. They also relied on some other personal feature which let them avoid being confused by gender when demonstrators were changed. We discuss these results in terms of dogs? ability to recognize individuals and the potential advantage of this skill for their lives in human environments.","palabras_clave":"DOGS|REPUTATION|SOCIAL COGNITION|DISCRIMINATION|INDIVIDUAL RECOGNITION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18108,"idioma_id":4,"titulo":"Seed rain alteration related to fire and grazing history in a semiarid shrubland","resumen":"In arid environments, the vegetation is distributed in patches. Herbivory and fires promote changes and seed rain plays a key role in the soil seed bank and the colonization of new spaces. This study focuses on the effect of different land use histories on the spatial and temporal seed rain distribution in Patagonia. We placed seed traps to capture the seed rain of perennial grasses, shrubs and annual forage dicots at five sites with different grazing and fire histories. Moderate grazing and fire enhanced seed rain diversity, whereas the absence of disturbances decreased it. Vegetation patches did not show any differences between sites, but at the interpatch level, grazing increased shrub seed and decreased perennial grass seed in the seed rain. Fire decreased the effects of grazing on shrub seed rain, but did not change its effects on perennial grasses.  Shrub species showed a minimum abundance in the seed rain in the undisturbed site. Our results suggest that the changes described for vegetative attributes are reflected in the seed rain, and this could reinforce the patch-interpatch pattern; fire did not reduce the grazing effects because it decreased the seed rain of the preferred grasses and increased the less preferred ones.","palabras_clave":"seed dispersal|perennial grasses|annual forage dicots|shrubs|land use history|vegetation patches"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18109,"idioma_id":4,"titulo":"Paspalum chilense (Poaceae, Paspaleae): A new species from southern South America","resumen":"Paspalum chilense, a new species from Chile belonging to the   informal Notata group, is described and illustrated on the basis of   morphological, cytological and molecular evidence. Our evidence supports   its affinity with P. barretoi and P. nummularium, from   Brazil, from which it probably diverged by vicariant speciation. The   limited available material of the new species was previously identified   as P. pumilum or P. minus. A new key to the species of the core Notata group is provided.","palabras_clave":"Notata group|Paspalum chilense|South America"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18110,"idioma_id":4,"titulo":"Amaranth protein films prepared with high-pressure treated proteins","resumen":"This work studies the effect of using high-pressure modified amaranth proteins in the preparation of ediblefilm and compares the efficiency of high pressure and thermal treatment on the functionality of amaranthprotein films. This films were prepared by casting using glycerol as plasticizer from proteindispersions submitted to high pressure treatments of different intensity (0.1, 200, 400 and 600 MPa).Protein dispersions treated with high-pressure were able to form uniform films with better mechanicalproperties, lower water solubility and water vapor permeability than those prepared from non-treatedprotein dispersions without modifying its thickness, color and water content, but somewhat more opaque.This could be attributed to structural changes by high-pressure treatment, which favored proteinunfolding, increasing protein surface hydrophobicity and the amount of free SH, that werere-associated during film formation producing a higher crosslinking of matrixes that was denoted in abetter functionality of films. These films also showed better properties than those prepared with amaranthprotein isolates thermally treated.","palabras_clave":"Protein films  | Amaranth proteins|High-pressure treatment|Protein cross-linking"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18111,"idioma_id":4,"titulo":"Microbiological prevention using functionalized materials as ecological additives in hygienic paints","resumen":"At the present time, one of the environmental challenges is the microbiological control in the indoor environment. Themicroorganisms that form biofilms on substrates located inside buildings and houses contribute to the formation of bio-aerosolswhen they are, partial or totally, dispersed and transported by the air. An example is the poisoning by certain fungal products asthe mycotoxins (carcinogenic) that comes from fungi that can generally be in the interiors of buildings. Therefore, it is of vitalimportance to contribute avoiding and\/or minimizing the microbiological growth in the indoor environments. In such sense theevaluation of new antimicrobial agents is of fundamental importance and can be applied in diverse areas of development ofprotective coating and construction materials. The global efforts to reduce the dangerous remainders and technologically cleanthe chemical processes are being integrated with modern progresses as much in science as in the industry. In this investigation wewill work with remainders of seeds of sunflower functionalized with 3-aminopropyltriethoxysilane (APS), as support ofadditives, to a compound of Mo and K, that will act as antimicrobial, to be used in hygienic paintings. The originating solid of thesunflower seeds will be functionalized by means of reactions between organosilanes and the superficial groups of the mentionedsolid. The characterization of synthesized solids will be made by means of SEM-EDS, DRX, FT-IR, textural properties,potentiometric titration, among others. These solids were microbiologically evaluated in front of fungi and bacteria, givingpromissory results for novel ecological additives in hygienic paints.","palabras_clave":"BIOCIDAS|ADITIVOS|ANTIMICROBIANOS|PINTURAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18112,"idioma_id":5,"titulo":"Pervalencia de endometritis subclínica en posparto de vacas lecheras de diferentes genotipos","resumen":"La endometritis subclínica (ES) es un patología que asienta sobre la mucosa del útero y carece de signos evidentes a la hora de realizar un examen clínico general en los animales. La misma se considera una afección endometrial importante que altera tanto índices de índole reproductivos como productivos. La incidencia de la ES se ve reflejada en incrementos de variables reproductivas como son el número de servicios por preñez, el intervalo parto-concepción, el intervalo parto-parto, los días de vacas vacías, así como los riesgos de rechazos por fallas reproductivas, entre tantos.  El objetivo del trabajo consiste en evaluar la prevalencia de ES en vacas lecheras en postparto de diferentes genotipos, mediante una técnica citológica de diagnóstico con el uso de Cytobrush.  Se utilizaron 60 vacas de diferentes genotipos en el período postparto comprendido entre 21 y 56 días en lactancia (DEL) de un establecimiento lechero cercano a la localidad de Paraná, perteneciente a la cuenca lechera Oeste o Principal de la Provincia de Entre Ríos. Todas las vacas se manejaron en la misma instalación de ordeño, consumiendo todas por igual las mismas pasturas, verdeos, forrajes conservados y concentrados. Todas las vacas estaban clínicamente sanas y con un estado corporal de 3 (escala 1-5). Las mismas, en base a sus cruzamientos, se agruparon por características genotípicas, es decir 15 vacas conformaron el Grupo 1 (F1): Holstein x Jersey, 15 animales el Grupo 2 (P): F1 x Pardo Suizo, 13 vacas el Grupo 3 (G): F1 x Guernsey y las restantes 17 el Grupo 4 (Retrocruza o R): P o G x Holstein.  En forma individual, fueron obtenidas muestras citológicas de la mucosa endometrial de la región del cuerpo o cuernos utilizando cepillos endocervicales adaptados (Medibrush XL, Medical Engineering Co, SA). Los frotis, realizados sobre portaobjetos limpios, fueron secados al aire y coloreados con Hematoxilina-Eosina. Una vez teñidos fueron observados al microscopio óptico para el conteo de células y estimación del % polimorfonucleares neutrófilos (PMN N) en relación a las células totales (células epiteliales más PMN N). Al microscopio óptico se contaron 200 células totales y sobre ellas se calculó la proporción de PMN N lo que se utilizó para caracterizar una inflamación del endometrio. El valor de corte de PMN N para ES se estableció en &#8805; 5%.  Para el análisis de los resultados se utilizó la prueba de contingencia de Chi cuadrado. Se estimó la prevalencia dentro de cada genotipo.  La prevalencia hallada (13.33%) está por debajo del 19% descripto en trabajos previos. Es de notar las diferencias de prevalencia de ES que hubo entre cada genotipo, siendo evidente G, en el que el 100% de las vacas resultaron sanas, mientras que F1 y P expresaron los porcentajes más altos de ES (26.67% y 20%). En relación al NP se observó una distribución variable dependiendo del genotipo ya que en F1 a medida que aumenta el NP se reduce el porcentaje de ES, por el contrario P y R aumentaron el porcentaje de ES con el NP, y en G no tuvo incidencia el NP en el desarrollo de ES. Cuando se observó la distribución por DEL, F1 es el más llamativo debido a su elevado valor en el último período de días en lactancia estudiado donde se ven afectadas de manera negativa las variables antes mencionadas. Otra particularidad fue que P y R mostraron una mejoría a lo largo de los DEL. Por lo expuesto se puede concluir que el desarrollo de ES, sería dependiente del genotipo estudiado, siendo G la que se comportaría mejor en relación a esta enfermedad. Así mismo consideramos de suma importancia continuar a futuro los estudios de dicha entidad.","palabras_clave":"ENDOMETRITIS SUBCLÍNICA|VACAS LECHERAS|GENOTIPO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18113,"idioma_id":4,"titulo":"Clinical, microbiological and genetic characteristics of heteroresistant vancomycin-intermediate Staphylococcus aureus bacteremia in a teaching hospital","resumen":"The emergence of vancomycin intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA)is of major concern worldwide. Our objective was to investigate the prevalence, phenotypic and molecularfeatures of hVISA strains isolated from bacteremic patients and to determine the clinical significance of thehVISA phenotype in patients with bacteremia. A total of 104 S. aureus blood isolates were collected from ateaching hospital of Argentina between August 2009 and November 2010. No VISA isolate was recovered, and3 out of 92 patients (3.3%) were infected with hVISA, 2 of them methicillin-resistant S. aureus (MRSA) (4.5%of MRSA). Macro Etest and prediffusion method detected 3\/3 and 2\/3 hVISA respectively. Considering the typeof bacteremia, the three cases were distributed as follows: two patients had suffered multiple episodes ofbacteremia (both hVISA strains recovered in the second episode), while only one patient had suffered asingle episode of bacteremia with hVISA infection. MRSA bloodstream isolates exhibiting the hVISA phenotypewere related to HA-MRSA Cordobes clone (ST5-SCCmec I-spa t149) and MRSA Argentinean pediatricclone (ST100-SCCmec IVNV-spa t002), but not to CA-MRSA-ST30-SCCmec IV-spa t019 clone that was one ofthe most frequent in our country. Although still relatively infrequent in our hospital, hVISA strains weresignificantly associated with multiple episodes of bacteremia ( p = 0.037) and genetically unrelated.","palabras_clave":"GENETIC|HETERORESISTANT|VANCOMYCIN|SATAPHYLOCOCCUS AUREUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18115,"idioma_id":4,"titulo":"A model for the Guaraní expansion in the La Plata Basin and littoral zone of Southern Brazil","resumen":"Since the 19th century, it has been proposed that the wide geographic distribution of the Guaraní indigenous populations in large areas of South America was the result of prehistoric movements of large numbers of people through the main rivers of the La Plata Basin and the Brazilian coastline. However, no detailed spatial and temporal analysis has been carried out with the dated Guaraní archaeological sites of the different zones of Brazil, Argentina, and Uruguay. This is one of the reasons why some of the main ideas about this past population expansion still lack empirical validation. This paper presents a study on the geographic and temporal distribution of the Guaraní archaeological sites in the La Plata Basin and the Atlantic coast of southern Brazil. The overall purpose is to contribute to understanding the Guaraní expansion using the analysis of two basic archaeological variables: space and time. Based on available numerical dates (14C and thermoluminescence) and the application of GIS software, potential dispersion routes are discussed. To date, more than 1100 archaeological sites assigned to the Guaraní, along with almost 250 numerical dates were analyzed. With this data, it was possible to elaborate a DispersionRoutes Model and a Temporal Visualization Model, which enabled identification of the sequence of population dispersal, with two main expansion pulses, throughout nearly two millennia of Guaraní movements across the South American Lowlands.","palabras_clave":"GUARANÍ ARCHAEOLOGY|SOUTH AMERICAN LOWLANDS|LATE HOLOCENE|GIS|RADIOCARBON AND THERMOLUMINESCENCE DATES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18116,"idioma_id":4,"titulo":"Reactive oxygen species partially mediate high dose angiotensin II-induced positive inotropic effect in cat ventricular myocytes","resumen":"          Background:  Reactive oxygen species, such as superoxide, are being increasingly recognized  as key components of a vast array of signaling pathways. Angiotensin II is a  well-recognized stimulus for superoxide production through NADPH oxidase  activation and opening of the mitochondrial ATP-sensitive potassium channels  (mKATP). A role for this mechanism has been proposed to explain  several physiological effects of the peptide. The aim of this study was to  evaluate the involvement of this mechanism in the inotropic response to 100  nmol\/L angiotensin II.          Methods: Sarcomere  shortening and intracellular pH (BCECF-epifluorescence technique) were  evaluated in isolated cat ventricular myocytes placed in a perfusion chamber on  the stage of an inverted microscope. Myocardial superoxide production was  evaluated by the lucigenin  quimioluminiscence method.          Results: Angiotensin  II (100 nmol\/L) increased ~ 70 % sarcomere shortening, effect that was only partially  prevented by NADPH oxidase inhibition, mKATP channel blockade or  inhibition of the cardiac Na+\/H+ exchanger (NHE-1).  Moreover, angiotensin II stimulates NHE-1 activity by a NADPH oxidase-dependent  mechanism. Myocardial superoxide production was also increased by angiotensin  II, and this action was completely prevented either by NADPH oxidase inhibition  or mKATP channel blockade.           Conclusions:  The positive inotropic response to 100 nmol\/L angiotensin II is due to both  ROS\/NHE-1 dependent and independent pathways, this being a point of divergence  with the signaling previously described to be triggered by lower concentrations  of angiotensin II (i.e.: 1 nmol\/L).  ","palabras_clave":"inotropism|angiotensin II|reactive oxygen species|NHE-1"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18117,"idioma_id":4,"titulo":"Philornis downsi (Diptera: Muscidae), an Avian Nest Parasite Invasive to the Galápagos Islands, in Mainland Ecuador","resumen":"Philornis downsi (Dodge and Aitken) is a bird-parasitic muscid fly native to mainland South America that recently invaded the Galápagos Islands where it is parasitizing Darwin?s finches and other land birds. This parasite was previously known only from Argentina, Brazil and Trinidad and Tobago. The first report of P. downsi from mainland Ecuador is provided, supporting the hypothesis that the invasion route of P. downsi from its native range to the Galápagos Islands includes mainland Ecuador. Three different morphologies of pupal exuviae, that belong to different fly species, were uncovered. Dipteran puparia were found in 20% of naturally occurring nests collected in 2013 and in 27% of nests in 2014 at 2 sites in western Ecuador. P. downsi accounted for 74% and 40% of the puparia in 2013 and 2014, respectively. Two new bird host species for the genus Philornis were recorded: the streak-headed woodcreeper (Lepidocolaptes souleyetii) and the fasciated wren (Campylorhynchus fasciatus). The levels of nest parasitism found were much lower than levels reported for the Galápagos Islands. Finally, parasitism of P. downsi by a parasitoid in the genus Brachymeria (Hymenoptera, Chalcididae) is documented. Overall, 9% of fly puparia collected in 2013, and 19% of those collected in 2014, had parasitoid emergence holes.","palabras_clave":"BIRD NEST BOXES|BRACHYMERIA|ECUADOR|GALAPAGOS ISLANDS|MUSCIDAE|PARASITOID|PHILORNIS DOWNSI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18118,"idioma_id":4,"titulo":"Structural, electronic and hyperfine characterization of pure and Ta-doped ZrSiO4","resumen":"The electronic structure of pure and Ta-doped ZrSiO4 in the tetragonal I41\/amd phase with andwithout defects  has been studied using the ab initio full-potential linear augmented plane wave plus local orbitals method. From  the determined charge densities, the electric field gradient tensor at native Zr sites and at Ta impurities localized  on cation sites of ZrSiO4 were derived and compared to experimental data obtained using hyperfine techniques.  The effects of the Ta probe atom, including its different charge states on the lattice, are investigated. In addition,  different types of defects, such as O or Si vacancies, Ta replacing Si, and Ta enclosed in microstructures of SiO2  phases, are examined. The combination of experiments and theory enables us to identify the different interactions  observed in Ta-doped ZrSiO4 and to elucidate the role played by different defects.","palabras_clave":"ab initio|zircon|hyperfine interactions|oxides"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18119,"idioma_id":4,"titulo":"?Structure and electrical behavior relationship of a Magnesium-Tellurite glass using Raman and Impedance Spectroscopy","resumen":"In this paperwe present the study of the glassy systems of formula: xMgO(1&#8722;x)(0.5V2O5·0.5MoO3)2TeO2,with(0 b x b 1). The aim of the work is to understand the relationship between in the induced changes in the glassymatrix by the incorporation of MgO in a vanadium?tellurite glass and the electrical response of the material. Ithas been found that the incorporation of MgO in the glassy matrix raises the glass transition temperature. Thewhole system's electrical behavior is explained by the small polaron hopping, in good agreement with the variablerange polaron hopping model. In this matrix, an ionic transport by Mg2+ is not allowed. The study gives anopportunity to understand how to tune in the middle-range glassy structural order and, as a direct implication,how to control the electrical conduction process.","palabras_clave":"Tellurite glasses|Impedance spectroscopy|Raman spectroscopy|Polaron hopping"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18120,"idioma_id":4,"titulo":"Saline waters and macroinvertebrates in subtropical Andean streams","resumen":"La salinidad de los ríos es una expresión de la concentración de sales solubles disueltas en la masa de agua. Salinización secundaria es el aumento de la salinidad de un cuerpo de agua como resultado de las actividades humanas. La salinidad puede  afectar la composición de la biota acuática, restringiendo las comunidades a la presencia de especies tolerantes.  En este estudio se analizó la relación entre las comunidades bentónicas y variables fisicoquímicas en sistemas naturales prístinos y ambientes con impacto antrópico. Se colectaron muestras de la comunidad bentónica con Red D y muestras de aguas para el análisis de los iones mayoritarios en el laboratorio. Los resultados  señalan que existe un límite crítico de conductividad eléctrica, por encima de 800µS\/cm, a partir del cual se produce un cambio de los taxones de macroinvertebrados bentónicos en los arroyos. La riqueza taxonómica resultó un indicador sensible para detectar los efectos de la salinización secundaria. El régimen monzónico de precipitaciones en la región ejercería una influencia importante en las condiciones del hábitat para la fauna bentónica debido a que controla la concentración de los iones mayores. En este sentido, los resultados obtenidos indican que las lluvias afectaron diferencialmente a las comunidades de macroinvertebrados de los arroyos andinos, mejorando su equitativita por debajo de 800µS\/cm en sitios de elevada salinidad pero cambiando la estructura de la comunidad de equitativa a dominada por un taxa, en sitios con menor salinidad.","palabras_clave":"SUDAMERICA|SALINIZACION SECUNDARIA|COMUNIDAD BENTONICA|LLUVIAS ESTACIONALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18121,"idioma_id":4,"titulo":"ABATEMENT OF OCHRATOXIN A FROM CONTAMINATED WINE AND GRAPE JUICE BY ACTIVATED CARBON ADSORPTION","resumen":"The ochratoxin A (OTA) is an organicand toxic for man compound, generated by fungiusually present in the vineyards. This compound canbe found in grape and its derivative products.In this article, activated carbon from grape stalkwas used as an adsorbent to reduce the concentrationof OTA in wine and grape must. The adsorptiontests were carried out following the same procedurefor wine and must. This procedure consisted in addingOTA to the samples; three aliquots were takenfrom them, putting each one in contact with differentamounts of activated carbon. In each of the tests, theconcentration of OTA was determined at 30, 60 and120 minutes by High Performance Liquid Chromatography(HPLC).Satisfying results were obtained, reducing OTAlevels by 80% in wine and 96% in must, when 100mg of carbon were used during 2 hours of contact.The influence of contacting with activated carbonon the color of wine was analyzed by spectrophotometry.Neither of the analyzed samples showed a significantvariation on color","palabras_clave":"OCHRATOXIN A|WINE|GRAPE JUICE|ACTIVATED CARBON ADSORPTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18122,"idioma_id":4,"titulo":"Development of a dual vaccine for prevention of Brucella abortus infection and Escherichia coli O157:H7 intestinal colonization","resumen":"Zoonoses that affect human and animal health have an important economic impact. In the study now presented, a bivalent vaccine has been developed that has the potential for preventing the transmission from cattle to humans of two bacterial pathogens: Brucella abortus and Shiga toxin-producing Escherichia coli (STEC). A 66 kDa chimeric antigen, composed by EspA, Intimin,&nbsp; Tir, and H7 flagellin (EITH7) from STEC, was constructed and expressed in B. abortus &#916;pgm vaccine strain (Bab&#916;pgm).&nbsp; Mice orally immunized with Bab&#916;pgm(EITH7) elicited an immune response with the induction of anti-EITH7 antibodies (IgA) that clears an intestinal infection of E. coli O157:H7 three times faster (t=4 days) than mice immunized with Bab&#916;pgm carrier strain (t=12 days). As expected, mice immunized with Bab&#916;pgm(EITH7) strain also elicited a protective immune response against B. abortus infection. A Brucella-based vaccine platform is described capable of eliciting a combined protective immune response against two bacterial pathogens with diverse lifestyles -the intracellular pathogen B. abortus and the intestinal extracellular pathogen STEC.","palabras_clave":"BRUCELLA|RECOMBINANT VACCINE|SHIGA-TOXIN PRODUCING ESCHERICHIA COLI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18123,"idioma_id":4,"titulo":"Composition of the lower cretaceous black shales from the Austral basin (Patagonia, Argentina): implication for unconventional reservoirs in the Southern Andes.","resumen":"The importance of the Río Mayer Formation (Lower Cretaceous, marine outer platform) in the hydrocarbon development of the Austral Basin (Patagonia, Argentina) has been recognized by several authors. This unit isplaying a key-role in the 'Inoceramus inferior-Springhill' petroleum system, which constitutesis the most important petroleum systemof the basin. The Río Mayer Formation mainly consists of laminated black shales with interbeddedmarls and sandstone levels. Compositional studies in outcrops of this unit are almost absent and constitute the main focus of this contribution. A total of ten detailed sedimentologicallogs were taking from the field andX-ray diffraction analysis (XRD), conventional petrography, scanning electron microscopy (SEM) and determination of major elements in clay minerals by EDAX were carried out in order to characterize the composition of the Río Mayer Formation....","palabras_clave":"CLAY ASSEMBLAGES|PETROGRAPHYCS ANALYSIS|SEM-EDAX|SHELE-OIL\/GAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18124,"idioma_id":4,"titulo":"Synthesis, structural and spectroscopic characterization of Thallium(I) Acesulfamate","resumen":"&nbsp;&nbsp;&nbsp;&nbsp; The new acesulfamate salt, TlC4H4NO4S,was prepared by reaction of acesulfamic acid and thallium(I) carbonate inaqueous solution.&nbsp; Its crystal andmolecular structure was determined by single crystal X-ray diffraction methods.The substance crystallizes in the monoclinic space group P21\/a, with unit cell parameters a = 7.5844(4) Å, b= 9.7268(5) Å, c = 10.8105(5) Å, &#946; = 105.174(6)°, and Z=4 molecules per unitcell, and is isostructural with the corresponding sodium, potassium, rubidiumand cesium salts. The FTIR and Raman spectra of the compound are also recordedand briefly discussed","palabras_clave":"THALLIUM(I) ACESULFAMATE|SYNTHESIS|CRYSTAL STRUCTURE|IR and RAMAN SPECTRA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18125,"idioma_id":4,"titulo":"A detailed experimental and theoretical study of two novel substituted trifluoromethyl chromones. The influence of the bulky bromine atom on the crystal packing","resumen":"The new 3-methyl-2-trifluoromethylchromone (1) and 3-bromomethyl-2-trifluoromethylchromone (2) compounds were synthesized and characterized by vibrational (IR, Raman), UV?Vis and NMR (1H, 13C and 19F) spectroscopy and MS spectrometry. The crystal structures of 1 and 2 were determined by X-ray diffraction methods. Both compounds crystallize in the monoclinic P21\/c space group with Z = 4molecules per unit cell. The structures were solved from 1423 (1) and 1856 (2) reflections with I &gt; 2r (I) and refined by full-matrix least-squares to agreement R1-values of 0.0403 (1) and 0.0554 (2). Because of p-bonding delocalization, the organic molecular skeletons are planar and the molecular bonding structures can be described by formally single, double and resonant bonds. In 2, the ACF3 group revealed a strong rotational disorder around the CACF3 bond, which could be explained in terms of four split positions with about uniform angular distribution. The vibrational, electronic and NMR, spectra were discussed and assigned with the assistance of DFT calculations.","palabras_clave":"Síntesis|Estudio Espectroscópico|Análisis Estructural|Cálculos Teóricos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18126,"idioma_id":4,"titulo":"Ammonium, barium hexacyanoferrate(II) trihydrate: synthesis, crystal structure, thermal decomposition and spectroscopic study","resumen":"The ammonium, barium hexacyanoferrate(II) trihydrate, Ba(NH4)2[Fe(CN)6]·3H2O, has been synthesized for the first time, was characterized by thermogravimetric and differential thermal analysis (TG?DTA), infrared (IR) and Raman spectroscopy and chemical analysis, and its crystal and molecular structures were determined by X-ray diffraction methods. The chemical composition was determined by assaying Ba(II) with EDTA, ammonia nitrogen with Nessler?s reagent as indicator and Fe(II) using spectrophotometry with ortho-phenanthroline method. The hydration number was estimated by thermogravimetric analysis. The compound crystallizes in the trigonal R-3c space group. The ferrocyanide anion has an almost perfect octahedral shape with its Fe(II) ion in a crystallographic special position of point symmetry S6 [d(Fe?C) = 1.912(2) Ang. , d(C?N) = 1.153(3) Ang. ]. The barium, ammonium nitrogen and water oxygen atoms are also at lattice special positions with site symmetries D3, C3 and C2, respectively. The thermal decomposition process was also studied using TG?DTA, and the products of decomposition were identified by IR spectroscopy. It proposes a mechanism of decomposition.","palabras_clave":"Ferrocyanide|Synthesis|Thermal analysis|Crystal structure|IR spectroscopy|hexacyanoferrate"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18127,"idioma_id":4,"titulo":"Nanomedicines against Chagas disease: an update on therapeutics, prophylaxis and diagnosis","resumen":"Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma cruzi. After a mostly clinically silent acute phase, the disease becomes a lifelong chronic condition that can lead to chronic heart failure and thromboembolic phenomena followed by sudden death. Antichagasic treatment is only effective in the acute phase but fails to eradicate the intracellular form of parasites and causes severe toxicity in adults. Although conventional oral benznidazol is not a safe and efficient drug to cure chronic adult patients, current preclinical data is insufficient to envisage if conventional antichagasic treatment could be realistically improved by a nanomedical approach. This review will discuss how nanomedicines could help to improve the performance of therapeutics, vaccines and diagnosis of Chagas disease.","palabras_clave":"TRYPANOSOMA CRUZI|CRHONIC CHAGAS CARDIOMYOPATHY|BENZNIDAZOLE|NANOMEDICINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18128,"idioma_id":4,"titulo":"Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens","resumen":"Abstract  Purpose. The vertebrate inner retina has a subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the nonvisual photopigment melanopsin. The intrinsically photosensitive retinal ganglion cells send light information from the environment to the brain to control, among other parameters, the amount of energy entering the eyes through the pupillary light reflex (PLR). A daily variation in the PLR in both mice and humans has recently been shown, indicating circadian control of this response. In a previous work involving the sensitivity spectra for the PLR, we showed that blind chickens (GUCY1*) display the highest sensitivity to light of 480 nm. The aim of the present study was to evaluate the potential circadian control of PLRs in blind birds under scotopic conditions.  Methods. Circadian PLR was performed on GUCY1* chickens with lights of different wavelengths (white or blue light of 475 nm) under scotopic conditions.  Results. We found a significant daily variation in the PLRs of chickens exposed to white or blue light of 475 nm, with increased sensitivity at circadian time 6 during the subjective day.  Conclusions. Our observations clearly point to circadian control of PLRs even in blindness, strongly indicating that both the entry of light into the eyes and its quality are differentially regulated during the day in diurnal animals.","palabras_clave":"Circadian|GUCY1* chickens"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18129,"idioma_id":4,"titulo":"Modulation of the electron transfer processes in  Au?ZnO nanostructures","resumen":"Plasmonic nanostructures comprising Au and ZnO nanoparticles synthesized by the spontaneous reduction of HAuCl4 in ethylene glycol were used to asses the possibility of modulating the direction of electron transfer processes at the interface. One electron UV reduction and visible oxidation of the reversible couple TEMPOL\/TEMPOL-H was confirmed by EPR spectroscopy. The apparent quantum yield for TEMPOL-H conversion under continuous wave visible excitation depends on the irradiation wavelength, being 0.57% and 0.27% at 450 ± 12 and 530 ± 12 nm. These results indicate that both the surface plasmon resonance and the interband transition from the 5d to 6s level of Au nanoparticles also contribute to the visible activity of the nanostructure. Additionally, by detecting free electron conduction band electrons in ZnO, after the visible excitation of Au\/ZnO nanostructures, we provide direct evidence of the photoexcited electron transfer from gold nanoparticles to ZnO.","palabras_clave":"NANOCOMPOSITES|ELECTRON TRANSFER|GOLD|PLASMONICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18130,"idioma_id":4,"titulo":"Teaching of mathematics and physics in secondary school through research and study paths","resumen":"This paper present a proposal for teaching based on the Research and Study Paths (RSP) involving Mathematics and Physics together at the Secondary School. We adopt the ideas of the Anthropological Theory of didactic (ATD). The Research and Study Path (RSP) and the Praxeological Model of Reference (PMR) are described and analyzed. We carried out an implementation with N=68 students of 5th year at the secondary school. Some results obtained in this experience are described.","palabras_clave":"Mathematics and Physics teaching|Anthropological Theory of Didactics (ATD)|Study and Research Paths (RSP)|Praxeological Model of Reference (PMR)"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18131,"idioma_id":4,"titulo":"Tautomerizable &#946;-Ketonitrile Copolymers for Bone Tissue Engineering: Studies of Biocompatibility and Cytotoxicity","resumen":"&#946;-ketonitrile tautomeric copolymers have demonstrated tunable hydrophilicity \/hydrophobicity properties according to surrounding environment, and mechanical properties similar to those of human bone tissue. Both characteristic properties make them promising candidates as biomaterials for bone tissue engineering. Based on this knowledge we have designed two scaffolds based on &#946;-ketonitrile tautomeric copolymers which differ in chemical composition and surface morphology. Two of them were nanostructured, using an anodized aluminum oxide (AAO) template, and the other two obtained by solvent casting methodology. They were used to evaluate the effect of the composition and their structural modifications on the biocompatibility, cytotoxicity and degradation properties. Our results showed that the nanostructured scaffolds exhibited higher degradation rate by macrophages than casted scaffolds (6 and 2.5 percent of degradation for nanostructured and casted scaffolds, respectively), a degradation rate compatible with bone regeneration times. We also demonstrated that the &#946;-ketonitrile tautomeric based scaffolds supported osteoblastic cell proliferation and differentiation without cytotoxic effects, suggesting that these biomaterials could be useful in the bone tissue engineering field.","palabras_clave":"TAUTOMERIC COPOLYMER|BONE TISSUE ENGINEERING|BIOCOMPATIBILITY|CYTOTOXICITY ASSAYS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18132,"idioma_id":4,"titulo":"Reduced levels of NADH-dependent glutamate dehydrogenase decrease the  glutamate content of ripe tomato fruit but have no effect on green fruit or leaf","resumen":"Glutamate (Glu) is a taste enhancer that contributes to the characteristic flavour of foods. In fruit of tomato (Solanumlycopersicum L.), the Glu content increases dramatically during the ripening process, becoming the most abundantfree amino acid when the fruit become red. There is also a concomitant increase in NADH-dependent glutamatedehydrogenase (GDH) activity during the ripening transition. This enzyme is located in the mitochondria and catalysesthe reversible amination of 2-oxoglutarate to Glu. To investigate the potential effect of GDH on Glu metabolism, theabundance of GDH was altered by artificial microRNA technology. Efficient silencing of all the endogenous SlGDHgenes was achieved, leading to a dramatic decrease in total GDH activity. This decrease in GDH activity did not leadto any clear morphological or metabolic phenotype in leaves or green fruit. However, red fruit on the transgenic plantsshowed markedly reduced levels of Glu and a large increase in aspartate, glucose and fructose content in comparisonto wild-type fruit. These results suggest that GDH is involved in the synthesis of Glu in tomato fruit during the ripeningprocesses. This contrasts with the biological role ascribed to GDH in many other tissues and species. Overall, thesefindings suggest that GDH has a major effect on the control of metabolic composition during tomato fruit ripening,but not at other stages of development.","palabras_clave":"GDH|TOMATO FRUIT|GLUTAMATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18133,"idioma_id":4,"titulo":"Biogeographical variation in arthropod communities on coyote bush (Baccharis pilularis).","resumen":"1. A classic pattern in biogeography is the decline in species richness from lower to higher latitudes. Communities, however, can also vary with other geographical patterns, such as the abiotic gradients that occur from coastal to interior habitats.  2. In this study, we surveyed arthropod communities and herbivore pressure on populations of a dominant shrub, Baccharis pilularis, across a 2000 km lati- tudinal transect to determine whether coastal versus interior location mediates arthropod responses to latitude.  3. We found that arthropod species richness and abundance declined with increasing latitude. We also found significant coastal-interior shifts in commu- nity composition and trophic structure. Specifically, predator and scavenger richness were two and three fold greater at coastal sites compared to interior sites, and were three- and six-fold more abundant on the coast than in the inte- rior. Herbivore pressure displayed a similar pattern, with greater abundance at lower latitudes and at coastal sites.  4. Our results corroborate the general macroecological pattern that diversity declines with increasing latitude, and that coastal versus interior location can also shape community assemblages. We did not, however, find any interaction between latitude and location suggesting the effect of latitude on arthropod communities remains consistent inland compared to more constant coastal conditions.","palabras_clave":"ARTHROPODS|COSTAL-INTERIOR GRADIENTS|HERBIVORE|LATITUDINAL GRADIENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18134,"idioma_id":4,"titulo":"PM10 emissions from aggregate fractions of an Entic Haplustoll under two contrasting tillage systems","resumen":"Tillage systems affect physical and chemical properties of soils modifying its aggregation. How changes ofthe aggregate size distribution affect the capacity of the soil to emit fine particulate matter (PM10) to theatmosphere during wind erosion processes, is a less investigated issue. In order to answer this question,PM10 emissions from an Entic Haplustoll submitted to 25 years of continuous conventional tillage (LC)and no-till (NT) were analyzed. Soil samples were sieved with a rotary sieve in order to determine theaggregate size distribution (fractions : 19.2 mm), the dry aggregate stability (DAS) and the erodible fraction (EF). The organic matter contents(OM), the particle size composition and the PM10 emission of each aggregate fraction were alsomeasured. Results showed that NT promoted OM accumulations in all aggregate fractions which favoredDAS and soil aggregation. The 19.2 mm(41.7%) in NT, while the proportion of the other aggregate fractions was similar in both tillage systems.As a consequence of the smaller proportion of the <0.42 mm aggregates, the erodible fraction was lowerin NT (EF: 17.3%) than in CT (30.8%). PM10 emissions of each aggregate fraction (AE) decreased exponentiallywith increasing size of the fractions in both tillage systems, mainly as a consequence of the smallersize and higher specific surface. AE was higher in CT than in NT for all aggregate fractions, but the higherdifferences were found in the <0.42 mm aggregates (18 lg g1 in CT vs 8 lg g1 in NT). The PM10 emissionof the whole soil was three times higher in CT than in NT, while the emission of the erodible fraction(EFE) was in CT four times higher than in NT. PM10 emissions of the <0.42 mm aggregates representedover 50% of SE and 90% of EFE. We concluded that NT reduced the capacity of soils of the semiaridPampas to emit PM10 because it produced a better aggregation that reduced the proportion and emissionof the <0.42 mm aggregates. These aggregates had, by far, the highest emission potential.","palabras_clave":"PM10 emission|Tillage systems|Dry aggregate distribution|Organic matter"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18135,"idioma_id":4,"titulo":"Bed expansion and particle classification in liquid fluidized beds with structured internals","resumen":"The inclusion of a structured packing as internal in a liquid-solid fluidized bed allows expansion of the liquid velocity operation range before elutriation, promoting the liquid solid contact and mixing. The bed expansion of liquid-solid fluidized beds provided with structured packing as internals is examined, for solids denser than the liquid phase and within a wide range of operating conditions. A correlation to estimate the bed expansion in liquid-solid fluidized beds using structured packing as internals is developed. In addition, the feasibility of employing structured packing as internals for favoring classification of different density particles is demonstrated by analyzing the mass elutriated from the column at different liquid velocities for single particles or binary mixtures.","palabras_clave":"Structured packings|Fluidized beds|Elutriation|Particle classification"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18136,"idioma_id":4,"titulo":"Cytotoxicity of corrosion products of degradable Fe-based stents: Relevance of pH and insoluble products","resumen":"Fe-based Biodegradable Metallic Materials (Fe-BMMs) have been proposed for cardiovascular applications and are expected to disappear via corrosion after an appropriate period. However, in vivo studies showed that Fe ions release leads to accumulation of orange and brownish insoluble products at the biomaterial\/cell interface. As an additional  consequence, sharp changes in pH may affect the biocompatibility of these materials. In the present work, the experimental protocols were designed with the aim of evaluating the relative importance that these factors have on biocompatibility evaluation of BMMs.  Mitochondrial activity (MTT assay) and thiobarbituric acid reactive substances (TBARS) assay on mammalian cells, exposed to 1-5 mM of added Fe3+ salt, were assessed and compared with results linked exclusively to pH effects. Soluble Fe concentration in culture medium and intracellular Fe content were also determined. The results showed that: i)mitochondrial activity was affected by pH changes in all the concentration range of added Fe3+ assayed, ii) at the highest added Fe3+ concentrations (&#8805;3 mM), precipitation was detected and the cells were able to incorporate the precipitate, that seems to be linked to cell damage, iii) the extent of precipitation depends on the Fe\/protein concentration ratio; and iv) lipid peroxidation products were detected in all the concentration range of added Fe3+. Hence, a new approach opens in the biocompatibility evaluation of Fe-based BMMs, since the cytotoxicity would not be solely a function of released (and soluble) ions but of the insoluble degradation product amount and the pH falling at the biomaterial\/cell interface. The concentration of Fe-containing products at the interface depends on diffusional conditions in a very complex way that should be carefully analyzed in the future.","palabras_clave":"Iron|Citotoxicity|stents|pH and insouble products"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18137,"idioma_id":4,"titulo":"Denoising sound signals in a bioinspired non-negative spectro-temporal domain","resumen":"The representation of sound signals at the cochlea and auditory cortical level has been studied as an alternative to classical analysis methods. In this work, we put forward a recently proposed feature extraction method called approximate auditory cortical representation, based on an approximation to the statistics of discharge patterns at the primary auditory cortex. The approach here proposed estimates a non-negative sparse coding with a combined dictionary of atoms. These atoms represent the spectro-temporal receptive fields of the auditory cortical neurons, and are calculated from the auditory spectrograms of clean signal and noise. The denoising is carried out on noisy signals by the reconstruction of the signal discarding the atoms corresponding to the noise. Experiments are presented using synthetic (chirps) and real data (speech), in the presence of additive noise. For the evaluation of the new method and its variants, we used two objective measures: the perceptual evaluation of speech quality and the segmental signal-to-noise ratio. Results show that the proposed method improves the quality of the signals, mainly under severe degradation.","palabras_clave":"Approximate auditory cortical representation|Sound denoising|Non-negative sparse coding|Bioinspired signal processing"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18138,"idioma_id":4,"titulo":"Accounting for unknown foster dams in the genetic evaluation of embryo transfer progeny","resumen":"Animals born by embryo transfer (ET) are usually not included in thegenetic evaluation of beef cattle for preweaning growth if the recipientdam is unknown. This is primarily to avoid potential bias in the estimationof the unknown age of dam. We present a method that allows includingrecords of calves with unknown age of dam. Assumptions are as follows:(i) foster cows belong to the same breed being evaluated, (ii) there is nocorrelation between the breeding value (BV) of the calf and the maternalBV of the recipient cow, and (iii) cows of all ages are used as recipients.We examine the issue of bias for the fixed level of unknown age of dam(AOD) and propose an estimator of the effect based on classical measurementerror theory (MEM) and a Bayesian approach. Using stochastic simulationunder random mating or selection, the MEM estimating equationswere compared with BLUP in two situations as follows: (i) full information(FI); (ii) missing AOD information on some dams. Predictions ofbreeding value (PBV) from the FI situation had the smallest empiricalaverage bias followed by PBV obtained without taking measurement errorinto account. In turn, MEM displayed the highest bias, although the differenceswere small. On the other hand, MEM showed the smallest MSEP,for either random mating or selection, followed by FI, whereas ignoringmeasurement error produced the largest MSEP. As a consequence fromthe smallest MSEP with a relatively small bias, empirical accuracies of PBVwere larger for MEM than those for full information, which in turnshowed larger accuracies than the situation ignoring measurement error.It is concluded that MEM equations are a useful alternative for analysingweaning weight data when recipient cows are unknown, as it mitigatesthe effects of bias in AOD by decreasing MSEP.","palabras_clave":"MEASUREMENT ERROR MODEL|MISSING RECIPIENT DAM|RECORDS FROM ET CALVES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18139,"idioma_id":4,"titulo":"Plant growth-promoting effects of native Pseudomonas strains on Mentha piperita (peppermint): an in vitro study","resumen":"Plant growth-promoting rhizobacteria (PGPR) affect growth of host plants throughvarious direct and indirect mechanisms. Three native PGPR (Pseudomonas putida)strains isolated from rhizospheric soil of a Mentha piperita (peppermint) crop fieldnear Cordoba, Argentina, were characterised and screened in vitro for plant growth promoting characteristics, such as indole-3-acetic acid (IAA) production, phosphatesolubilisation and siderophore production, effects of direct inoculation on plantgrowth parameters (shoot fresh weight, root dry weight, leaf number, node number)and accumulation and composition of essential oils. Each of the three native strainswas capable of phosphate solubilisation and IAA production. Only strain SJ04 produced siderophores. Plants directly inoculated with the native PGPR strains showed increased shoot fresh weight, glandular trichome number, ramification number and root dry weight in comparison with controls. The inoculated plants had increasedessential oil yield (without alteration of essential oil composition) and biosynthesis of major essential oil components. Native strains of P. putida and other PGPR have clear potential as bio-inoculants for improving productivity of aromatic crop plants. There have been no comparative studies on the role of inoculation with native strains on plant growth and secondary metabolite production (specially monoterpenes). Native bacterial isolates are generally preferable for inoculation of crop plants because they are already adapted to the environment and have a competitive advantage over nonnative strains.","palabras_clave":"AROMATIC PLANTS|ESSENTIAL OILS|MENTHA PIPERITA|NATIVE PSEUDOMONAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18141,"idioma_id":4,"titulo":"Anatomical, morphological, and phytochemical effects of inoculation with plant growth promoting rhizobacteria on peppermint (Mentha piperita).","resumen":"Plant growth-promoting rhizobacteria (PGPR) generally  exert their effects through enhancement of plant nutrient  status and\/or phytohormone production. The effects of PGPR  on aromatic plant species are poorly known. We measured  plant growth parameters, chlorophyll content, trichome density,  stomatal density, and levels of secondary metabolites in peppermint  (Mentha piperita) seedlings inoculated with PGPR  strains Bacillus subtilis GB03, Pseudomonas fluorescens  WCS417r, P. putida SJ04, or a combination of WCS417r+  SJ04. The treated plants, in comparison with controls, showed  increases in shoot biomass, root biomass, leaf area, node number,  trichome density, and stomatal density, and marked qualitative  and quantitative changes in monoterpene content.  Improved knowledge of the factors that control or affect biosynthesis  of secondary metabolites and monoterpene accumulation  will lead to strategies for improved cultivation and productivity  of aromatic plants and other agricultural crops without  the use of chemical fertilizers or pesticides.","palabras_clave":"Glandular trichome|Mint|Secondary metabolites|Stomatal density|Lamiaceae sustainable agriculture"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18142,"idioma_id":5,"titulo":"CARACTERIZACIÓN GEOQUÍMICA DEL MAGMATISMO DE ARCO DEVÓNICO Y CARBONÍFERO-PÉRMICO EN EL NOROESTE DE PATAGONIA, ARGENTINA'.","resumen":"Based on 23 whole rock chemical analyses of the igneous basement rocks from the Northwest Patagonia, Neuquén, Río Negro and Chubut provinces, we characterize the magmatism and tectonic setting for the región between 40º and 42º S, further west of 70º W. The analysed rocks are mainly granitoids (with one migmatite and another meta-basite), with ductile deformation. Previously, all these rocks have been isotopically dated by U-Pb, K-Ar and Sm-Nd methods, and then the crystallization and metamorphism-deformation ages, and extraction time from the mantle are known. According to their geological ages, they have been separated into Chanic (Devonian) and Gondwanic Groups (Carboniferous-Permian). In both cases, the granitoids are subalkaline, normal calc-alkaline, I- type, peraluminous, and related to their respective magmatic arcs, developed on continental margin. The Gondwanic granitoids were also compared with the granitoids of the same age ranging from Northpatagonian Massif, Cordillera Norpatagónica, and Cordillera Frontal from Mendoza (Argentina) and Chile.","palabras_clave":"PATAGONIA|BASAMENTO|GEOQUIMICA|MAGMATISMO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18143,"idioma_id":4,"titulo":"Tin coatings electrodeposited from sulfonic acid based electrolytes:  Tribological behaviour","resumen":"A high efficiency methane sulfonic acid electrolyte used for tin electrodeposition was studied, and the properties of the resulting deposits were compared to those of tin coatings obtained from an industrial phenol sulfonic acid electrolyte. Cyclic voltammetry was used to study the effect of organic additives on the reduction process to define the composition of the electrolytic  bath. Thick tin electrodeposits were obtained on rotating cylinder steel electrodes and their surface morphology, preferred crystal orientation, surface roughness, micro hardness and tribological behaviour were measured. Smooth, adherent and bright tin coatings were obtained  from the methane sulfonic acid electrolyte, which differed in morphology and texture from tin electrodeposited from the industrial bath. Influence of organic additives on preferred crystal orientation of the coatings was found to be stronger than changing the supporting sulfonic acid type. Tribological tests showed that the two types of deposits have a similar coefficient of friction. However, tin coatings obtained from methane sulfonic electrolytes presented a lower wear resistance and underwent galling at lower loads.","palabras_clave":"TIN|PHENOL SULFONIC ACID|METHANE SULFONIC ACID|COATINGS|TRIBOLOGY|WEAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18144,"idioma_id":5,"titulo":"Terapia Cognitiva basada en Atención Plena (mindfulness) y la 'tercera ola' en Terapias Cognitivo-Conductuales","resumen":"El artículo aborda las razones que dieron lugar a la incorporación de la atención plena (mindfulness) en el abordaje cognitivo de la prevención de las recaídas y recurrencias en los trastornos depresivos recurrentes. Se presenta el contexto en el cual se pasó de los modelos cognitivo-conductuales centrados en los contenidos de la cognición a aquellos centrados en el rol de los procesos cognitivos. Se destacan los problemas que presentó el modelo cognitivo estándar para explicar la vulnerabilidad cognitiva de los pacientes que habiendo experimentado un episodio depresivo se encuentran en remisión. Se describe brevemente el modelo cognitivo sobre el cual se basa la terapia cognitiva basada en la atención plena (MBCT) y su propuesta de tratamiento.","palabras_clave":"Terapia cognitiva|Atención plena|Depresión"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18145,"idioma_id":4,"titulo":"In-line coupled single drop liquid-liquid-liquid microextraction with capillary electrophoresis for determining fluoroquinolones in water samples","resumen":"A simple in-line single drop liquid-liquid-liquid microextraction (SD-LLLME)  coupled with capillary electrophoresis (CE) for the determination of two  fluoroquinolones was developed. The method is capable to quantify trace amount of analytes in water samples and to improve the sensitivity of CE detection. For the SDLLLME, a thin layer of organic phase was used to separate a drop of 0.1 M NaOH hanging at the inlet of the capillary from the aqueous donor phase. By this way, the analytes were extracted to the acceptor phase through the organic layer based on their acidic\/basic dissociation equilibrium. The drop was immersed into the organic phase during 10 min for extraction and then it is directly injected into the capillary for the analysis. Parameters such as type and volume of organic solvent phase, aqueous donor and acceptor phases and extraction time and temperature were optimized. The enrichment factor was calculated, resulting 40-fold for enrofloxacin (ENR) and 6-fold for ciprofloxacin (CIP). The linear range were 20-400 &#956;g·L-1 for ENR and 60-400 &#956;g·L-1 for CIP. The detection limits were 10.1 &#956;g·L-1 and 55.3 &#956;g·L-1 for ENR and CIP respectively and a good reproducibility was obtained (4.4% for ENR and 5.6% for CIP). Two real water samples were analysed applying the new method and the obtained results presented satisfactory recovery percentages (90?100.3%).","palabras_clave":"Capillary electrophoresis|Single drop  microextraction|In-line coupling"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18146,"idioma_id":4,"titulo":"From Semantic to Social Deficits: Dysfunction of the  Nondominant Posterior Peri-Sylvian Area in Schizophrenia","resumen":"Schizophrenia is characterized by profound deficits in social competence and functioning, independent from active psychoticsymptoms at different stages of the disease. Social deficits in schizophrenia are clinically well characterized, but their neurobiological underpinnings are undetermined. This article reviews recent evidence supporting heritable deficits in a circuitnecessary for appropriate naming of emotions and mental states in others, centered at the temporoparietal junction of the nondominant hemisphere. The clinical implications of this model are discussed, including the potential use of rehabilitation techniques oriented to recognition and naming of emotions and mental states as a necessary step for social rehabilitation.","palabras_clave":"SCHIZOFRENIA|NON DOMINANT HEMISPHERE|SOCIAL DEFICITS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18147,"idioma_id":5,"titulo":"Sociabilidades juveniles en escuelas secundarias. Un análisis de las prácticas relacionales  y los procesos de reconocimiento entre estudiantes","resumen":"En este artículo presentaremos resultados del proyecto de investigación ?Sociabilidades juveniles y lógicas de reconocimiento en la escuela?, cuyo propósito es comprender las prácticas relacionales de distintas juventudes en la escuela media y su interjuego con las regulaciones escolares y representaciones de los educadores. Desde este marco investigativo destacamos la relevancia de atender a los ensayos de conocimiento y reconocimiento en las prácticas relacionales como modo de asignación de sentidos a los otros y a sí mismos. Esto implica indagar tanto procesos de diferenciación que apelan a estigmatizaciones, prácticas discriminatorias, confrontaciones como a la definición de espacios de pertenencia grupal y procesos de integración que permiten poner a prueba las construcciones identitarias.    El estudio se enmarca en el paradigma interpretativo-cualitativo y se trabaja con un diseño de estudio de casos. Para la construcción de datos se combinan distintas técnicas (análisis de documentación institucional, observaciones de jornadas escolares, entrevistas individuales y grupales con estudiantes y entrevistas a docentes y directivos). En la primera etapa del actual período (2012-2013) seleccionamos dos establecimientos de gestión pública de la ciudad de Córdoba. Al interior de estos casos se muestreó a grupos de alumnos de diferentes ciclos de escolaridad. En el artículo presentaremos un análisis sobre algunas prácticas relacionales y procesos de reconocimiento entre estudiantes de distintos ciclos de escolarización en contexto socio institucionales específicos.","palabras_clave":"JUVENTUDES|ESCUELA SECUNDARIA|PRÁCTICAS RELACIONALES|PROCESOS DE RECONOCIMIENTO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18148,"idioma_id":4,"titulo":"EFFECT OF THE WATER-ETHANOL MOLAR RATIO IN THE ETHANOL STEAM REFORMING REACTION OVER A Co\/CeO2\/MgAl2O4 CATALYST","resumen":"Co(8%)\/MgAl2O4 catalyst with Ce addition was prepared and characterized bydifferent tecniques (BET, DRX, SEM-EDX, RTP and TG-TPO). Its catalyticperformance was tested in the ethanol steam reforming reaction at 650°C and aW\/FC2H5OH= 50 g min mol&#8722;1 using different molar ratios H2O:C2H5OH (MR) in thefeed. The presence of 5 wt.%Ce on catalyst markedly increased the hydrogenselectivity (from 3.2 to 5.2 molH2\/molC2H5OH for MR=4.8) and the carbon resistance.The increase of molar ratio water:ethanol led to a significant decrease in the CO\/CO2ratio (from 0.84 for RM=4.8 to 0.5 for RM=8) and in the carbon amount after 7 h instream (from 22.9% for RM=4.8 to 6.8% for RM=8). Molar ratios higher than 7 did notsignificantly improved the catalytic performance. Taking into account previous studiesabout thermal balance of this reaction, the optimum molar ratio in the ethanol steamreforming seems to be around 6. The ethanol conversion was nearly constant after 7 hin spite of the carbon amount detected by TG-TPO and SEM-EDX. It could be inferredthat an important Co fraction was exposed on the filament tips and\/or a fraction ofcarbonaceous species was deposited on the support surface.","palabras_clave":"Ethanol Steam Reforming|Hydrogen Produccion|Co Catalyst"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18149,"idioma_id":4,"titulo":"Cenozoic building and deformational processes in the North Patagonian Andes","resumen":"        Abstract        The   Oligocene to present evolution of the North Patagonian Andes is   analyzed linking geological and geophysical data in order to decipher   the deformational processes that acted through time and relate them to   basin formation processes. Seismic reflection profiles reveal the   shallow structure of the retroarc area where contractional structures,   associated with Oligocene to early Miocene inverted extensional   depocenters, are partially onlapped by early to late Miocene synorogenic   deposits. From the construction of five structural cross sections along   the retroarc area between 40° and 43°30&#8242;&nbsp;S, constrained by surface,   gravity and seismic data, a shortening gradient is observed along Andean   strike. The highest shortening of 18.7&nbsp;km (15.34%) is determined near   41°30&#8242;&nbsp;S coincidentally with maximum mean topographic values on the   eastern Andean slope, where basement blocks were uplifted in the   orogenic front area, and the deepest and broadest synorogenic   depocenters were formed towards the foreland. Additionally, eastward   shifting of Miocene calc-alkaline rocks occurred at these latitudes,   which is interpreted as indicative of a change in the subduction   parameters at this time. Deep crustal retroarc structure is evaluated   through inversion of gravity models that made possible to infer Moho   attenuated zones. These coincide with the occurrence of younger than   5&nbsp;Ma within-plate volcanics as well as with crustal thermal anomalies   suggested by shallowing of the Curie isotherm calculated from magnetic   data. Younger volcanism and thermal anomalies are explained by slab   steepening since early Pliocene, after a mild-shallow subduction setting   in the middle to late Miocene, age of the main compressive event.","palabras_clave":"Andean orogenesis|Patagonian Andes,Shortening; Foreland basin|Shallow subduction; Arc migration;|Gravity and magnetic data"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18150,"idioma_id":4,"titulo":"Porphyry to epithermal transition in the Altar porphyry Cu-(Au-Mo) deposit, Argentina, studied by cathodoluminescence, LA-ICPMS, and fluid inclusions","resumen":"The middle to late Miocene Altar porphyry Cu-(Au-Mo) deposit, located in the Andean Main Cordillera of San Juan Province (Argentina), is characterized by the superposition of multiple vein generations consisting of both porphyry-type and high sulfidation epithermal-style alteration and mineralization. We constrain the physical and chemical evolution of the hydrothermal fluids that formed this deposit based on description and distribution of vein types, scanning electron microscopy, cathodoluminescence (CL) imaging, trace elements in quartz veins, and fluid inclusion microthermometry.Quartz CL textures and trace elements (chiefly Li, Al, Ti, and Ge) differentiate among quartz generations precipitated during different mineralization and alteration events. Early quartz ± chalcopyrite ± pyrite veins and quartz ± molybdenite veins (A and B veins) show considerable complexity and were commonly reopened, and some underwent quartz dissolution. Early quartz ± chalcopyrite ± pyrite veins (A veins) are dominated by equigranular bright CL quartz with homogeneous texture. Most of these veins contain higher Ti concentrations than any other vein type (average: 100 ppm) and have low to intermediate Al concentrations(65?448 ppm). Quartz ± molybdenite (B veins) and chlorite + rutile ± hematite (C veins) veins contain quartz of intermediate CL intensity that commonly shows growth zones with oscillatory CL intensity. Quartz from these veins has intermediate Ti concentrations (~20 ppm) and Al concentrations similar to those of A veins. Quartz from later quartz + pyrite veins with quartz + muscovite ± tourmaline halos (D veins) has significantly lower CL intensity, low Ti (zones. Late veins rich in sulfides and sulfosalts show CL textures typical of epithermal deposits (dark CL quartz, crustiform banding, and euhedral growth zones). Quartz from these veins typically contains less than 5 ppm Ti, and Al, Li, and Ge concentrations are elevated relative to other vein types. Based on experimentally established relationships between Ti concentration in quartz and temperature, the decrease in Ti content in successively later quartz generations indicates that the temperature of the hydrothermal fluids decreased through time during the evolution of the system. Vein formation at Altar occurred at progressively lower pressure, shallower paleodepth, and lower temperature.Under lithostatic pressures, the magma supplied low-salinity aqueous fluids at depths of ~6 to 6.8 km (pressures of 1.6?1.8 kbar) and temperatures of 670° to 730°C (first quartz generation of early quartz ± chalcopyrite ± pyrite veins). This parental fluid episodically depressurized and cooled at temperatures and pressures below the brine-vapor solvus. Quartz ± molybdenite veins precipitated from fluids at temperatures of 510° to 540°C and pressures of 800 to 1,000 bars, corresponding to depths of 3 to 3.7 km under lithostatic pressures. Further cooling of hydrothermal fluids to temperatures between 425° and 370°C under hydrostatic pressures of 200 to 350 bars produced pyrite-quartz veins and pervasive quartz + muscovite ± tourmaline and illite alteration that overprinted the early hydrothermal assemblages. Late veins rich in sulfides and sulfosalts that overlapped the deep and intermediate high-temperature veins formed from fluids at temperatures of 250° to 280°C and pressures of 20 to 150 bars. The epithermal siliceous ledges formed from low-temperature fluids (<230°C) at hydrostatic pressures of <100 bars corresponding to depths of <<1 km","palabras_clave":"PORPHYRY Cu(Au-Mo)|HIGH SULFIDATION LEDGES|CATHODOLUMINESCENCE\t|FLUID INCLUSIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18151,"idioma_id":5,"titulo":"MICROFÁBRICAS DE DEFORMACIÓN DEL BASAMENTO METAMÓRFICO,  SECTOR CENTRO-ORIENTAL DE LA SIERRA DE COMECHINGONES, CÓRDOBA","resumen":"El presente trabajo tiene como eje fundamental el análisis de las microfábricas deformacionales presentes en las rocas del basamentocristalino expuesto en el sector centro-oriental de la sierra de Comechingones, Córdoba. Este complejo metamórficoestá compuesto principalmente por metatexitas y diatexítas, de manera subordinada aparecen gneises biotíticos granatíferos,anfibolitas, filonitas, pequeños bancos de mármoles y escasos cuerpos pegmatíticos de composición granítica. El conjunto delas microestructuras y microtexturas generadas durante los procesos de metamorfismo y migmatización (microtexturas poiquiloblásticasy de intercrecimiento), junto con las asociadas a los procesos de deformación intracristalina (maclado mecánico,kinking, creep por difusión, recuperación, entre otros), permiten interpretar los mecanismos actuantes, así como las condicionestermobarométricas a las cuales fueron sometidas las rocas del complejo metamórfico en estudio, estableciéndose una evolucióngeológica del área dividida aquí en tres eventos. Un primer estadio M1 - D1 en condiciones de grado medio y facies de anfibolitaalmandínica (6 kbar y 630 ºC). Un segundo evento M2 - D2 de carácter regional, asociado al clímax metamórfico en faciesde anfibolita alta a granulita (~7,5 kbar y 750 ºC). Un tercer evento M3 caracterizado por desarrollarse en dos fases diferentes,M3a en un contexto dúctil (5 kbar y 640 ºC) y M3b, en un ambiente dúctil-frágil (3,5 a 4 kbar y 400 - 450 ºC).","palabras_clave":"MICROTEXTURA-MICOESTRUCTURA|SIERRA DE COMECHINGONES|METAMORFISMO|DEFORMACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18152,"idioma_id":4,"titulo":"A MODEL FOR PREDICTING DIAMETER OF 'RED SENSATION' PEARS","resumen":"The pear cultivar ?Red Sensation? is showing popularity in the industry, because of its highly-colored, sweet and juicy fruit. Fruit size is critical for marketing pear; therefore, knowledge of growth dynamics becomes essential to program harvesting with minimum losses of size and flavor. The objective of this work was to develop a model to predict the seasonal growth for ?Red Sensation? pears, expressed in terms of fruit diameter as a function of time from full bloom. Fruit growth was followed at the Experimental Farm of the Universidad Nacional del Comahue, High Valley region, Río Negro, Argentina (38°56?S; 67°59?W), located in an arid region, with average annual rainfall of 250 mm, on a sandy loam soil, during the 2005-06, 2006-07, 2008-09, 2009-10 and 2010-11 growing seasons. The orchard was irrigated by surface flooding, and cultural practices were performed according to the local standard program. Trees were selected at random, and maximum fruit diameter (FD) measurements were carried out every two weeks with a Vernier caliper. The range of sampling dates was 19 and 117 days after full bloom (DFB). Equations were developed with SYSTAT procedure. The R2 values and residual mean squares were used to evaluate the goodness-to-fit of the models. Results showed that the following logistic model provided the most satisfactory fit to the pooled data (n=695), as compared to the power and linear equations: FD (mm)= 81.49\/(1 + e1.9865-0.0301 DFB), R2=0.92, P<0.001. Fruit maximal absolute growth rate, derived from the selected function, was 0.61 mm\/day. A prediction chart was based on the development of the equation and showed ?Red Sensation? pear sizes, at various times after 112 DFB, with practical application to aid crop marketing. This model can also be used for planning orchard practices such as thinning and irrigation.","palabras_clave":"PYRUS COMMUNIS|GROWTH|MODELING|SIGMOID CURVE|SIZE PREDICTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18153,"idioma_id":4,"titulo":"-\tBidimensional and Doppler ultrasonographic evaluation of postpartum uterine involution in the queen","resumen":"The aim of this study was to describe bidimensional and Doppler ultrasonographic changes of uterine involution during normal feline puerperium. Secondary, the postpartum vaginal discharge was described. Twelve pregnant female cats were included in this study. After queening, vulvar discharge was grossly and microscopically examined daily. Bidimensional and Doppler ultrasonographic examinations of the uterus were performed on Days 4 to 2, 4, 11, 18, and 25 from parturition. Total uterine diameter, uterine wall thickness, uterine lumen contents, peak systolic velocity, end diastolic velocity, and resistance index of uterine arteries were measured. The cats presented serosanguineous vulvar discharge for a mean of 3  1 days after parturition, and the cytology revealed 70% to 80% of erythrocytes, which progressively decreased up to Day 13. Immediately after parturition, there were less than 20% neutrophils, and this percentage gradually diminished to 0% to 1% at the end of the study. Uterine total diameter diminished up to Day 25 (P < 0.01), when ultrasonographic uterine dimensions were similar to that of anestrus. A progressive decrease of uterine wall thickness (P < 0.05), uterine lumen contents (P < 0.01), peak systolic velocity (P < 0.01), and end diastolic velocity (P < 0.01) was found throughout the study period. Conversely, resistance index increased during the first week after parturition (P < 0.01). It is concluded that the uterine artery blood flow progressively decreased during the first 25 days after parturition, which was associated with the bidimensional ultrasonographic regression of the organ. Although lochial discharge disappeared far before ultrasonographic involution, cytologic findings further corroborated the duration of this regression process.","palabras_clave":"Doppler|Ultrasound|Feline|Puerperium"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18154,"idioma_id":4,"titulo":"Hydrogeochemistry and sustainability of freshwater lenses in the Samborombón Bay wetland, Argentina","resumen":"Freshwater lenses constitute one of the most vulnerable aquifer systems in the world, especially in coastal wetland areas. The objectives of this work are to determine the hydrogeochemical processes that regulate the quality of the freshwater lenses in a sector of the Samborombón Bay wetland, and to assess their sustainability as regards the development of mining activities. A hydrochemical evaluation of groundwater was undertaken on the basis of major ion, trace and environmental isotope data. The deterioration in time of the freshwater lenses in relation to mining was studied on the basis of the analysis of topographic charts, aerial photography and satellite imaging. The results obtained show that the CO2(g) that dissolves in the rainwater infiltrating and recharging the lenses is converted to HCO3&#8722;, which dissolves the carbonate facies of the sediment. The exchange of Ca2+ for Na+, the incongruent dissolution of basic plagioclase and the reprecipitation of carbonate produce a change of the Ca-HCO3 facies to Na-HCO3. In depth, the pH increases with the groundwater flow, and the volcanic glassis dissolved, releasing F&#8722;and As. Besides, the evapotranspiration processes cause the saline content to increase slightly. As the only sources of drinking water in the region are the freshwater lenses occurring in the shell ridges, mining operations have deteriorated this resource and decreased the freshwater reserves in the lenses.The study undertaken made it possible to develop some preservation, remediation and management guidelines aimed at the sustainability of the water resources in the region.","palabras_clave":"FRESHWATER RESOURCES|HYDROGEOCHEMISTRY|SHELL RIDGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18155,"idioma_id":4,"titulo":"Synthesis, DFT calculations of structure, vibrational and thermal decomposition studies of the metal complex Pb[Mn(C3H2O4)2(H2O)2]","resumen":"The metallo-organic complex Pb[Mn(C3H2O4)2(H2O)2] was synthesized and characterized by IR and Raman spectroscopy and Powder X-ray diffraction methods. The cell parameters for the complex were determined from powder X-ray diffraction using the autoindexing program TREOR, and refined by the Le Bail method with the Fullprof program. A hexagonal unit cell was determined with a = b= 13.8366(7) Å, c = 9.1454(1) Å, &#947; = 120°. The DFT calculated geometry of the complex anion [Mn(C3H2O4)2(H2O)2]2- is very close to the experimental data reported for similar systems. The IR and Raman spectra and the thermal analysis of the complex indicate that only one type of water molecules is present in the structure. The thermal decomposition of Pb[Mn(C3H2O4)2(H2O)2] at 700 °C in air produces PbO and Pb2MnO4 as final products. The crystal structure of the mixed oxide is very similar to that reported for Pb3O4.","palabras_clave":"METALLO-ORGANIC COMPLEX|THERMAL DECOMPOSITION|IR AND RAMAN SPECTROSCOPY|DFT CALCULATIONS|POWDER DIFFRACTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18156,"idioma_id":4,"titulo":"Chaos in kicked ratchets","resumen":"We present a minimal one-dimensional deterministic continuous dynamical system that exhibits chaotic behavior and complex transport properties. Our model is an overdamped rocking ratchet with finite dissipation, that is periodically kicked with a &#948; function driving force, without finite inertia terms or temporal or spatial stochastic forces. To our knowledge this is the simplest model reported in the literature for a ratchet, with this complex behavior. We develop an analytical approach that predicts many key features of the system, such as current reversals, as well as the presence of chaotic behavior and bifurcation. Our analytical approach allows us to study the transition from regular to chaotic motion as well as a tangent bifurcation associated with this transition. We show that our approach can be easily extended to other types of periodic driving forces. The square wave is shown as an example.","palabras_clave":"KICKED RATCHETS|SYNCRONIZATION|CURRENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18157,"idioma_id":4,"titulo":"Paleoenvironmental reconstruction of the coastal monte léon and santa cruz formations (early Miocene) at Rincón del Buque, southern Patagonia: A revisited locality","resumen":"Sedimentological, ichnological and paleontological analyses of the Early Miocene uppermost Monte León Formation and the lower part of the Santa Cruz Formation were carried out in Rincón del Buque (RDB), a fossiliferous locality north of Río Coyle in Santa Cruz province, Patagonia, Argentina. This locality is of special importance because it contains the basal contact between the Monte Léon (MLF) and the Santa Cruz (SCF) formations and because preserve a rich fossil assemblage of marine invertebrates and marine trace fossils, and terrestrial vertebrate and plants, which has not been extensively studied. A ~90 meter-thick section of the MLF and the SCF that crops out at RDB was selected for this study. Eleven facies associations (FA) are described, which are, from base to top: subtidal?intertidal deposits with Crassotrea orbignyi and bioturbation of the Skolithos-Cruziana ichnofacies (FA1); tidal creek deposits with terrestrial fossil mammals and Ophiomorpha isp. burrows (FA2); tidal flat deposits with Glossifungites ichnofacies (FA3); deposits of tidal channels (FA4) and tidal sand flats (FA5) both with and impoverish Skolithos ichnofacies associated; marsh deposits (FA6); tidal point bar deposits recording a depauperate mixture of both the Skolithos and Cruziana ichnofacies (FA7); fluvial channel deposits (FA8); fluvial point bar deposits (FA9); floodplain deposits (FA10); and pyroclastic and volcaniclastic deposits of the floodplain where terrestrial fossil mammal remains occur (FA11).   The transition of the MLF?SCF at RDB reflects a changing depositional environment from the outer part of an estuary (FA1) through the central (FA2?6) to inner part of a tide-dominated estuary (FA7). Finally a fluvial system occurs with single channels of relatively low energy and low sinuosity enclosed by a broad, low-energy floodplain dominated by partially edaphized ash-fall, sheet-flood, and overbank deposits (FA8?11). Pyroclastic and volcaniclastic materials throughout the succession must have been deposited as ash-fall distal facies in a fluvial setting and also were carried by fluvial streams and redeposited in both estuarine and fluvial settings. These materials preserve most of the analyzed terrestrial fossil mammals that determinate the Santacrucian age of the RDB´s succession. Episodic sedimentation under volcanic influence, high sedimentation rates and a relatively warm and seasonal climate are inferred for the MLF and SCF section.   Lateral continuity of the marker horizons at RDB serve for correlation with other coastal localities such as the lower part of the coastal SCF south of Río Coyle (~17.6?17.4 Ma) belonging to the Estancia La Costa Member of the SCF.","palabras_clave":"ESTUARINE AND FLUVIAL SYSTEMS|VOLCANIC INPUT|ICHNOLOGY|FOSSIL MAMMALS|NEOGENE|SANTA CRUZ PROVINCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18158,"idioma_id":4,"titulo":"NFLUENCE OF TEMPERATURE, ANIONS AND SIZE DISTRIBUTION ON THE ZETA  POTENTIAL OF  DMPC, DPPC AND DMPE LIPID VESICLES.","resumen":"The purpose of the work is to compare the influence of the   multilamellarity, phase state, lipid head groups and ionic media on the   origin of the surface potential of lipid membranes. With this aim, we   present a new analysis of the zeta potential of multilamellar and   unilamellar vesicles composed by phosphatidylcholines (PC) and   phosphatidylethanolamines (PE) dispersed in water and ionic solutions of   polarizable anions, at temperatures below and above the phase   transition. In general, the adsorption of anions seems to explain the   origin of the zeta potential in vesicles only above the transition   temperature (Tc). In this case, the sign of the surface potential is   ascribed to a partial orientation of head group moiety toward the   aqueous phase. This is noticeable in PC head groups but not in PEs, due   to the strong lateral interaction between PO and NH group in PE.","palabras_clave":"PHOSPHOLIPIDS|VESICLES|ANIONS|WATER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18159,"idioma_id":4,"titulo":"Chasing cardiac physiology and pathology down the CaMKII cascade","resumen":"Calcium dynamics is central in cardiac physiology, as the key event   leading to the excitation-contraction coupling (ECC) and relaxation   processes. The primary function of Ca2+ in the heart is the control of mechanical activity developed by the myofibril contractile apparatus. This key role of Ca2+ signaling explains the subtle and critical control of important events of ECC and relaxation, such Ca2+ influx and SR Ca2+ release and uptake. The multifunctional Ca2+-calmodulin-dependent   protein kinase II (CaMKII) is a signaling molecule that regulates a   diverse array of proteins involved not only in ECC and relaxation, but   also in cell death, transcriptional activation of hypertrophy,   inflammation and arrhythmias. CaMKII activity is triggered by an   increase in intracellular Ca2+ levels. This activity can be sustained, creating molecular memory after the decline in Ca2+   concentration, by autophosphorylation of the enzyme, as well as by   oxidation, glycosylation and nitrosylation at different sites of the   regulatory domain of the kinase. CaMKII activity is enhanced in several   cardiac diseases, altering the signaling pathways by which CaMKII   regulates the different fundamental proteins involved in functional and   transcriptional cardiac processes. Dysregulation of these pathways   constitutes a central mechanism of various cardiac disease phenomena,   like apoptosis and necrosis during ischemia\/reperfusion injury,   digitalis exposure, post-acidosis and heart failure arrhythmias, or   cardiac hypertrophy. Here we summarize significant aspects of the   molecular physiology of CaMKII and provide a conceptual framework for   understanding the role of the CaMKII cascade on Ca2+ regulation and dysregulation in cardiac health and disease.","palabras_clave":"CaMKII|Arrhythmias|ischemia-reperfusion|calcium"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18160,"idioma_id":4,"titulo":"Recovery of caprine whey protein and its application in a food protein formulation","resumen":"This study investigated the recovery of proteins from whey caprine cheese which is mostly discarded as waste. A membrane process including microfiltration and tangential ultrafiltration was used to purify and concentrate the protein solution, reaching a 91.4 g\/100 g of protein concentration. The concentrate was then freeze-dried and characterized. The good emulsifying properties, high water and oil holding capacity and the rheological behavior suggested the application of the whey protein concentrate in the formulation of a dressing. Physico-chemical characterization indicated that the samples were similar to a commercial dressing in viscosity, texture, moisture and ash contain. Also the sensory analysis demonstrated a good acceptance mainly in color and flavor of the samples. However, the protein content of the product: 0.97 ± 0.12 g\/100 g, duplicated the value of the commercial sample incorporating higher addedvalue to a product with high consumption.","palabras_clave":"Caprine cheese whey |Ultrafiltration |Whey protein concentrate |Protein dressing"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18161,"idioma_id":5,"titulo":"Validación del modelo de curvas de Conductividad Eléctrica en el tiempo en cultivares de soja y trigo","resumen":"La integridad de la membrana, medida por la  Conductividad Eléctrica (CE), se considera un indicador del vigour de muchas  especies de semillas. El objetivo de este estudio se dividió en dos partes. La  primera consistió en validar un modelo matemático empleado previamente en  semillas de soja (Glycine max L. Merrill) para evaluar curvas de CE en el  tiempo y valorar así distintos materiales. La segunda radicó en determinar el  método de operación del equipo para cariopsis de trigo (Triticum aestivum L.).  Se usaron 8 muestras de soja expuestas a distintos ambientes controlados de  invernadero y de lotes de producción, que fueron cosechados tanto manual como  mecánicamente entre 2010 y 2012 en la provincia de Santa Fe, Argentina. Además,  se usaron 18 muestras de trigo expuestas también a condiciones ambientales  controladas de invernadero y lotes de producción, provenientes del mismo  período y la misma provincia. Todas las muestras se ajustaron a una humedad  entre 10 y 14 % y se conservaron en bolsas de papel madera a 4 °C hasta su uso.  Se midieron las curvas de CE para 100 semillas y cariopsis individuales de cada  muestra durante 20 horas de inmersión a intervalos de 3 minutos, usando el  analizador automático de semillas SAD 9000S. El comportamiento de todas las  muestras de semillas de soja se ajustó favorablemente al modelo previamente  propuesto. Además, las muestras de cariopsis presentaron curvas de acumulación  de electrolitos lixiviados en el tiempo que se ajustaron de manera propicia a  las condiciones sugeridas para el caso de soja. El método de evaluación del  vigour a través de la medición de la CE individual permitió validar el modelo  matemático de las curvas de CE en semillas de distintos cultivares de soja y de  cariopsis de trigo. Este método fue eficiente además, para identificar muestras  que presenten diferencias de potencialidad de emergencia a campo.","palabras_clave":"GLYCINE MAX|TRITICUM AESTIVUM|CONDUCTIVIDAD ELÉCTRICA|VIGOR|SAD 9000S"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18162,"idioma_id":5,"titulo":"Observatorio de inteligencia territorial y prácticas de investigación con actores comunitarios. El Central (San Martín, Mendoza)","resumen":"La perspectiva de Inteligencia Territorial (IT) es el medio que tienen investigadores y actores de una comunidad para planificar, definir, animar y evaluar políticas y acciones orientadas a obtener un mejor conocimiento del lugar que habitan y con ello alcanzar el desarrollo territorial sustentable. Se trata de poner el conocimiento al servicio de esa meta para responder ¿qué necesita la gente?, los recursos disponibles ¿alcanzan para satisfacer esas necesidades? e identificar y valorar cuáles son las oportunidades y vulnerabilidades del territorio.Se trabaja con comunidades escasamente integradas al entorno inmediato, con débil cohesión social, alto grado de individualismo, escaso sentido comunitario y mínimo conocimiento del potencial económico, social y territorial.Es el caso del distrito El Central, Departamento de San Martín en el Este mendocino. Como pequeña localidad en un espacio deprimido, con rasgos de marginalidad socio- territorial y diversidad de actores en visible proximidad experimenta la indiferencia de parte de los organismos de gestión.Los objetivos inmediatos son coordinar el trabajo de los actores locales en el manejo de herramientas metodológicas y generar conocimiento sobre el territorio en los aspectos población, actividades, necesidades y recursos. En talleres comunitarios se capacita a la población local en un relevamiento por encuesta para conocer cuántos habitantes tiene El Central, cuáles son sus necesidades básicas y cómo ven su distrito.La aplicación de la metodología de investigación\/acción da como resultado la apropiación colectiva de la información, la puesta en valor de las fortalezas del lugar, la organización de la comunidad y la formulación de propuestas de desarrollo.","palabras_clave":"Inteligencia territorial|Investigación acción|Desarrollo|Población"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18163,"idioma_id":4,"titulo":"Conversion of Viticultural Industry Wastes into Activated Carbons for Removal of Lead and Cadmium","resumen":"Many industrial activities generate large quantities of biomass wastes. The use of these to produce added value products or energy has become very important in recent years. Heavy metals as lead and cadmium are among the most toxic chemical water pollutants from natural or anthropogenic sources. This paper presents the studies carried out to assess the feasibility of preparing activated carbons from grape industrialization wastes of Cuyo Region, Argentina, grape stalk, lex and pomace, and their application for the removal of lead and cadmium. These materials were activated with steam. The activation conditions of each material were adjusted until the porosity and yield were acceptable. Products were characterized by their textural (BET area, porous volume) and physicochemical properties (proximate and elemental analysis, acid and basic surface groups, pHpzc, FTIR). In order to determine the effectiveness of these products on lead and cadmium adsorption, kinetics and equilibrium assays were carried out. Adsorption data were fitted to Langmuir and Freundlich models.All the adsorbents obtained were mainly microporous and showed a markedly basic character with pHpzc values above 10. The study of the effect of pH over lead and cadmium adsorption showed that the maximum retention of metal is attained at pH 5.5 and 6, respectively. Removal percentages around 98% were reached when grape pomace activated carbons were used. The other adsorbents showed lower removal efficiency. Adsorbent textural properties did not show influence on cadmium and lead adsorption under the experimental conditions of this work. The pH of suspensions was a relevant variable in the adsorption of metals and their regulation was difficult. Consequently, the removal of lead and cadmium was attributed to the combined effect of adsorption and precipitation.","palabras_clave":"Viticultural waste; Lead; Cadmium; Adsorption| Lead|Cadmium|Adsorption"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18164,"idioma_id":4,"titulo":"SAFETY OF A NASAL VACCINE AGAINST STREPTOCOCCUS PNEUMONIAE USING HEAT-KILLED LACTOBACILLUS CASEI AS ADJUVANT","resumen":"Streptococcus pneumoniae is a highly important respiratory pathogen that causes infections in children, elderly people and immunocompromised people around the world. Pneumococcal vaccines licensed did not reach to eradicate the pneumococcal infection. In a previous study was demonstrated the effectiveness of a nasal experimental vaccine that consisted in a pneumococcal protective protein A (PppA) co-administrated with heat-killed-Lactobacillus casei (LcM), in mice model of respiratory pneumococcal challenge. In the present work the safety of the experimental vaccine LcM+PppA and its components were evaluated through hematological, biochemical and immune parameters in a model infection with Streptococcus pneumoniae. Thus, Alanine Transaminase activity, creatinine levels, Lactate Dehydrogenase activity, C Reactive Protein levels, Corticosterone levels in serum, total and differential leukocyte counts in blood and bronchoalveolar lavages (BAL) and IgE in BAL, were evaluated. Experimental vaccine: LcM+PppA nasally administered does not induce harmful effects in our vaccination-infection model. Studied parameters showed LcM+PppA?s safety in liver, kidney, pulmonary and systemic levels. Although studies in experimental animals do not guarantee security for the application of the vaccine on humans, they are important evidence for the planning and subsequent clinical trials in humans.","palabras_clave":"VACCINE SAFETY|NASAL SAFETY|ADJUVANT |HATKILLED LACTOBACILLI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18165,"idioma_id":4,"titulo":"TD-DFT calculations of UV absorption bands and their intensities in the spectra of some tetrahydroquinolines","resumen":"A detailed analysis of the MOs involved in electronic transitions in UV spectra as well as a conformational study of 1-benzenesulfonyl-1,2,3,4-tetrahydroquinoline (BSTHQs) derivatives have been carried out  using the TD-DFT (B3LYP\/6-31+G(d,p)) method. Based on experimental solvent effects and theoretical investigations the long-wavelength bands have been assigned to p \/ p* transitions caused by HOMO?LUMO intramolecular charge transfer from the tetrahydroquinoline fragment (THQ) to the benzenesulfonyl moiety (BS). Nevertheless, for the NO2 derivative the HOMO?LUMO transition was found to be forbidden. In this case the long-wavelength band has been associated to an n \/ p*  transition. Good correlation of theoretical and experimental data for the energy transitions and the molar extinction coefficients of the compounds studied has been obtained and is presented for the first time.","palabras_clave":"TD-DFT calculations|UV absorption|tetrahydroquinolines benzenesulfonyl"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18166,"idioma_id":4,"titulo":"Regulatory cells induced by acute toxoplasmosis prevent the development of allergic lung inflammation","resumen":"Abstract: The increased prevalence of allergies in developed countries has been attributed to a  reduction of some infections. Supporting epidemiological studies, we previously showed that both  acute and chronic T. gondii infection can diminish allergic airway inflammation in BALB\/c mice. The  mechanisms involved when sensitization occurs during acute phase would be related to the strong Th1  response induced by the parasite. Here, we further investigated the mechanisms involved in T. gondii  allergy protection in mice sensitized during acute T. gondii infection. Adoptive transference assays and  ex vivo co-cultures experiments showed that not only thoracic lymph node cells from infected and  sensitized mice but also from non-sensitized infected animals diminished both allergic lung  inflammation and the proliferation of effector T cells from allergic mice. This ability was found to be  contact- independent and correlated with high levels of CD4+FoxP3+ cells. IL-10 would not be involved  in allergy suppression since IL-10-deficient mice behaved similar to wild type mice. Our results extend  earlier work and show that, in addition to immune deviation, acute T. gondii infection can suppress  allergic airway inflammation through immune suppression.","palabras_clave":"ALLERGY|IMMUNE SUPPRESSION|INFLAMATION|LUNG|REGULATORY CELLS|TOXOPLASMA GONDII"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18167,"idioma_id":4,"titulo":"Coincidence of extendible vector-valued ideals with their minimal kernel","resumen":"We provide coincidence results for vector-valued ideals of multilinear operators. More precisely, if Ais an ideal of n-linear mappings we give conditions for which theequality A(E1, ..., En; F) =Amin(E1, ..., En; F) holds isometrically. As an application, we obtain in many cases that the monomials form a Schauder basis of the space A(E1, ..., En; F). Several structural and geometric properties are also derived using this equality. We apply our results to the particular case where Ais the classical ideal of extendible or Pietsch-integral multilinear operators. Similar statements are given for ideals of vector-valued homogeneous polynomials.","palabras_clave":"Multilinear mappings |Radon?Nikodým property |Polynomial ideals |Metric theory of tensor products"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18168,"idioma_id":4,"titulo":"Ultrasonographic and progesterone changes during days 21 to 63 of pregnancy in queens","resumen":"Pregnancy diagnosis and gestational age are data commonly request in small animal reproduction practice. Ultrasonography studies have been used extensively to diagnose and monitor pregnancy. However, in the queen most of ultrasonographic and endocrinological studies have been performed using small number of observations during limited periods of pregnancy. The aim of this study was too was to perform daily ultrasonographic embryo\/fetus measurements and serum P4 concentrations measurements from gestational age 21 to 1 day prior to parturition to derive equations to use in clinical practice. Females were daily monitored by ultrasonography since Day 21 to the end of pregnancy and gestational sac (GS) length (LEN), anterior-posterior (ATP), width (WID), GS volume (GSV), GS diameter (GSD), uterine wall thickness (UW), crown-rump length (CRL), head diameter (HD), body diameter (BD) measurements, and serum P4 concentration were recorded. Data were analyzed by ANOVA, correlation and linear regression analysis, and equations to were derived to estimate the predicted values and 95% CI for GS parameters and P4 concentrations from day 21 to 63 of gestation and to estimate predicted values and 95% CI for fetal parameters from day 35 to 63 of gestation. A positive and significant correlation was found between ultrasonographic measurements and gestational age (r > 0.80, LEN, ATP, WID, CRL, HD, and BD; but a negative and significant correlation was found between serum P4 concentration and gestational age (r > -0.50, LEN, ATP, HD, BD). Equations derived to predict embryo\/fetal parameters had an r2 > 0.85 (LEN, WID, HD, GSV, GSD, and P4). In conclusion, the equations derived from this study will be useful for monitoring pregnancy in the queen from gestational day 21 to the end of pregnancy.","palabras_clave":"QUEEN|PREGNANCY|PROGESTERONE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18169,"idioma_id":5,"titulo":"¿Afectó el avance de la agricultura y la sojización la productividad de los suelos pampeanos?","resumen":"No disponible","palabras_clave":"Región Pampeana|Degradación de suelos|Productividad"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18170,"idioma_id":4,"titulo":"Impurities and electronic localization in graphene bilayers","resumen":"We analyze the electronic properties of bilayer graphene with Bernal stacking and a low concentration of adatoms. Assuming that the host bilayer lies on top of a substrate, we consider the case where impurities are adsorbed only on the upper layer. We describe nonmagnetic impurities as a single orbital hybridized with carbon?s p$_z$ states. The effect of impurity doping on the local density of states with and without a gated electric field perpendicular to the layers is analyzed. We look for Anderson localization in the different regimes and estimate the localization length. In the biased system, the field-induced gap is partially filled by strongly localized impurity states. Interestingly, the structure, distribution, and localization length of these states depend on the field polarization.","palabras_clave":"quantum transport|graphene|localization|adatoms"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18171,"idioma_id":4,"titulo":"Doing Gender in a Toxic World. Women and Freebase Cocaine in the City of Buenos Aires (Argentina)","resumen":"Consumption of freebase cocaine in Argentina has been investigated among males but not females. This qualitative study focuses on the complexity of relationships between gender identity and the use of drugs, investigating freebase cocaine as an example in the Metropolitan Area of Buenos Aires, Argentina. In-depth interviews were conducted with female consumers in 2010. The results reveal the different ways in which female identity is constructed in the context of social vulnerability. We identify ways of doing gender and feeling like a woman in a man´s world that are associated with a higher risk of violence and exclusion for being female.","palabras_clave":"ARGENTINA|FREEBASE COCAINE (freebase or paco)|GENDER IDENTITY|QUALITATIVE STUDY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18172,"idioma_id":4,"titulo":"Protein tyrosine phosphatase 1b (PTP1B) is involved in the defective erythropoietic function of carbamylated erythropoietin","resumen":"IntroductionIt is now recognized that the carbamylation of erythropoietin(Epo) in lysine residues makes this protein unable to act as a growthfactor for erythropoiesis, while it retains its ability to protect neu-ronal cells from damage. In accordance with other authors (Brineset al., 2004; Leist et al., 2004; Coleman et al., 2006; Fantacci et al.,2006), we demonstrated that Epo and cEpo exerted similar pro-tective effects on neuroblastoma-derived SH-SY5Y cells induced toapoptosis by staurosporine or TNF-, while cEpo was unable to sup-port proliferation of the UT-7 and TF-1 cell lines, both capable oferythroid differentiation (Chamorro et al., 2013). Furthermore, inthis previous paper we presented an advance on the study of thedifferential effects between Epo and cEpo on hematopoietic andnon-hematopoietic cells, since we reported the inability of cEpo tocompletely activate cell proliferation signaling pathways","palabras_clave":"ERYTHROPOIETIN|CARBAMYLATED ERYTHROPOIETIN|PTP1B|CELLULAR PROLIFERATION|TYROSINE PHOSPHATASES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18173,"idioma_id":4,"titulo":"Ontogenetic integration between force production and force reception: a case study in Ctenomys (Rodentia: Caviomorpha)","resumen":"Abstract  During ontogeny, complex adaptations undergo changes that sometimes entail different functional capabilities. This fact constrains the behaviour of organisms at each developmental stage. Rodents have ever-growing incisors for gnawing, and a powerful jaw musculature. The incisors are long enough, relative to their diameter, to be affected by bending stresses. This is particularly true in the subterranean Ctenomys that uses its incisors for digging. We measured bite force (BF) in individuals of different ages using a force transducer. We estimated incisor section modulus Z, a geometrical parameter proportional to bending strength. A relative strength indicator was calculated as S = Z\/BF incisor length. We found that ontogenetic BF scales to body mass with positive allometry. However, an anova showed non-significant differences in S, neither between sexes nor among age classes. This result implies that during growth, incisors might have a rather similar ability to withstand bending stresses from increasing masticatory forces, what may be considered evidence of ontogenetic integration of force production (by muscles) and force reception (by the incisors). This fact well correlates with the observation that pups and juveniles of C. talarum incorporate solid foods shortly after birth, and they are able to dig burrows early in life.","palabras_clave":"desarrollo|integración|biomecánica|rodentia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18174,"idioma_id":4,"titulo":"Genetic diversity among plants of non-transgenic and transgenic versions of a single cross maize hybrid","resumen":"Previous studies have documented that transgene introduction may alter the phenotypic expression of several traits (e.g. biomass production, grain yield). We hypothesized that genetic diversity could influence the phenotypic variation among hybrids of a same genetic background and also among plants of a hybrid. The objectives of this preliminary study were: (i) to quantify the genetic  diversity between the non-transgenic (DK747) and transgenic versions (DK747MG, DK747RR and DK747MGRR) of a single-cross maize hybrid and among plants of each version, (ii) to observe the distribution of genetic diversity along the genome, and (iii) to explore relationships between phenotypic variability and genetic diversity. Hybrids were cultivated at field conditions during two growing seasons and plants of each hybrid with high, intermediate and low biomass at physiological maturity were selected to perform a study of single nucleotide polymorphisms (SNP). Genetic diversity among plants of each version was greater than among versions and both sources of variation were significant (?³ST=0.45, P<0.01). Genetic diversity of the non-transgenic DK747 was higher than those of  the transgenic versions, probably reflecting the conventional breeding history of these iso-hybrids. Similarity coefficients indicate that the most homogeneous group was that composed by plants of DK747MGRR. A Fisher?Ls exact test together with a principal component analysis identified certain SNPs related to the contrasting plant biomass of DK747, 747MG and DK747RR. Caution should be  taken with these results, because of the small sample size for SNPs study and the narrow set of tested hybrids.","palabras_clave":"Genetic Diversity|Non-transgenic Hybrid|Transgenic Hybrid|Single Nucleotide Plymorphism"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18175,"idioma_id":4,"titulo":"Conditioned taste aversion in the grey fox (Pseudalopex griseus), in Southern Argentine Patagonia","resumen":"Attempts to control cougar (Puma concolor) and culpeo fox (Pseudalopex culpaeus) populations in Patagonia through poisoning, negatively affects grey foxes (Pseudalopex griseus) and many other non-target species. It is therefore advisable to develop selective predator control methods. Among a wide range of potential methods, are those based on manipulating the behaviour of non-target species. Conditioned taste aversion (CTA) develops when an animal associates taste with subsequent illness, and, after recovery, avoids the referent taste. Food aversions can be potentially useful in efforts to reduce losses of non-target species when lethal baits are distributed to control other predators. We evaluated two ways to add the aversion agent Levamisole hydrochloride to a bait to generate CTA in grey foxes. We established one control (without Levamisole) and two treatments: plain Levamisole and an ion-exchange resin complex (resinate: Amberlite® IRP-64) aiming to mask the taste of Levamisole. Foxes that ate plain Levamisole baits, ate fewer baits than those in control (26.7% plain Levamisole baits vs. 83.3% untreated baits, P = 0.002) even after plain Levamisole was no longer present in the baits (40.0% vs. 86.6% untreated baits, treatment and control respectively, P = 0.007). Foxes that ate Levamisole resinate baits, also ate fewer baits than those in control (50.0% Levamisole resinate baits vs. 83.3% untreated baits, P = 0.043) but then resumed consumption when baits no longer contained the Levamisole resinate (73.3% vs. 86.6% untreated baits, treatment and control respectively, P = 0.329). Thus, foxes that failed to detect the plain Levamisole in baits acquired CTA to the bait. Contrary to our expectations, foxes detected the Levamisole resinate, associated illness with it and so resumed eating baits as soon as the resinate was withdrawn. Additionally, in the control, where foxes were familiar with untreated ?safe? baits, we repeated the treatment with Levamisole resinate baits to test latent inhibition (decrement in conditioning to a stimulus as a result of its prior exposure). We found that treated bait consumption did not decrease as before, during a similar number of days (76.6% Levamisole resinate baits vs. 83.3% untreated baits, P = 0.631), suggesting that latent inhibition prevented development of CTA within our experimental time period. CTA induced among grey foxes that consume plain Levamisole baits might spare them from being poisoned in attempts to control other species of predators.","palabras_clave":"zorro gris|aversión al sabor|conservación|patagonia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18176,"idioma_id":4,"titulo":"19th century wooden ship sheathing. A case of study: the materials of Puerto Pirámides 1, Península Valdés","resumen":"Copper alloy sheathing  used to protect ships hulls from different wood-infesting organisms (borers and  foulers) was widespread since the late 18th century. In this work the characterization  results of a sheathing fragment and tacks from the site Puerto Pirámides 1, Peninsula Valdes (Chubut Province, Argentina)  are presented. Through metallographic analysis by means of Light Microscopy and  Scanning Electron Microscopy (SEM), and chemical composition determination by  Energy Dispersive X-ray Spectrometry (EDS) it was possible to identify  compositions and microstructures different from those of artefacts of similar  kind found in shipwrecks of the same period.","palabras_clave":"COPPER-ALLOY SHEATHING|ARCHAEOMETALLURGY|19TH CENTURY SHIPWRECK"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18177,"idioma_id":4,"titulo":"Genetic improvement of peanut in Argentina between 1948 and 2004: links between phenology and grain yield determinants","resumen":"In the mid 1970s, there was a shiftin peanut cultivars used in Argentina, from cultivars with erect growth habit(CEGH) to those with procumbent growth habit (CPGH), which improved seed yield,but also lengthened growth cycle. However, there is no information on (i) thepartitioning of thermal time (TT) requirements between vegetative andreproductive phases, as well as between reproductive sub-phases representativeof the seed set and seed-filling periods, and (ii) the effect of developmentalchanges on growth traits. Field experiments were performed to compute TT, grainyield determinants (i.e., seed number and seed weight), and other relatedphysiological traits. Eight cultivars released between 1948 and 2004 were evaluated.The introduction of CPGH produced a lengthening (31%) of peanut growth cycle(S?R8), which was more pronounced for the reproductive phase (+39% for R1?R8)than for the vegetative phase (+17% for S?R1). This trend held for pod-set(R3?R6.5: +37%) and seed filling (R5?R8: +57%) sub-phases. It also held (CPGH&gt; CEGH) for the rate of flower production (+80%), total flower number (+36%)and number of pods per plant (+117%), and consequently for the fertility index(+56%). The enhanced seed number of CPGH was related to (r2 = 0.55, P &lt;0.001) the variation in crop growth rate during the seed set period(CGRR3?R6.5), but not to the duration of this period. Variations in CGRR3?R6.5were partially explained by differences in cumulative IPAR, which were linkedto the duration of the R3?R6.5 period as well as to maximum light interceptionfraction. These trends may have management as well as breeding origins.Introduction of the procumbent habit enhanced seed weight (CPGH &gt; CEGH) andseed-filling duration markedly, but had no effect on seed-filling rate. Seedweight, however, was positively related to this rate (P &lt; 0.01) andexhibited a negative trend in response to the duration of the period. Lack ofsource limitations on seed filling suggest that future breeding efforts shouldfocus on the increase of seed numbers and the reduction of seed fillingduration.","palabras_clave":"Peanut|Thermaltime|Fertilityindex|Seedweight"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18178,"idioma_id":4,"titulo":"Can top-down and bottom-up forces explain phytoplankton structure in a subtropical and shallow groundwater connected lake?","resumen":"Bottom-up and top-down control of phytoplankton is one of the most important hypothesis that explains and predicts the structure of aquatic community. Our aim was to elucidate whether predation and resource limitation can control phytoplankton composition and abundance in a subtropical shallow lake with groundwater connection to the river system. During 12 months, the lake was sampled at three points. Physico-chemical parameters, phytoplankton and zooplankton were sampled fortnightly, whereas fish were sampled every 3 months. The results showed that Euglenophyta dominated the total biovolume, followed by Dinophyta and Cryptophyta. As for the species composition, Chlorophyta was the dominant group (80 species recorded), followed by phylum Cyanobacteria (26 species recorded). Redundancy analysis (RDA) indicated that temperature and nitrate þ nitrite concentration mainly explained biovolume changes, with zooplankton predation not having any measurable effect on phytoplankton during the high-water (HW) period. During low-water (LW) period top-down by fish was more important. At higher taxonomic resolution (species biovolume), phosphorus was another controlling factor. We concluded that phytoplankton in this lake is mainly regulated by hydrological changes as a macrofactor that affects nutrient availability and other environmental conditions. Even though bottom-up top-down forces do not have a central effect, we found evidence of positive nutrient influences at theHWperiod and fish effect at the LW period.","palabras_clave":"PHYTOPLANKTON|ECOLOGY|EUTROPHICATION|FRESHWATER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18179,"idioma_id":4,"titulo":"Structural, conformational and vibrational properties of 1,1,1-Trifluoro- N-(1,1,2,2,2-pentafluoroethyl) methanesulfinimidoyl chloride, CF3CF2&#8210;N=S(Cl)CF3","resumen":"The structural, conformational, and configurational properties of 1,1,1-trifluoro-N-(1,1,2,2,2-pentafluoroethyl) methanesulfinimidoyl fluoride, CF3CF2N=S(F)CF3 have been studied by vibrational spectroscopy [IR (vapor) and Raman (liquid)] and quantum chemical calculations [B3LYP, MP2 and B3PW91 levels of theory (using the 6-311+G(d) and 6-311+G(2df) basis sets). According to these theoretical approximations, CF3CF2N=S(F)CF3 might be found in the gas phase as a mixture of a favoured anticlinal form (C-N bond anticlinal with respect to the C-S-F bisector angle) and a less abundant syn conformer showing C1 symmetry as well (&#916;G° 1.5 kcal.mol-1). However, corresponding vibrational modes for these configurations show only small shifts which would not allow confidently detecting the rather small contribution of this second conformer in the experimental spectra.","palabras_clave":"VIBRATIONAL SPECTROSCOPY|QUANTUM CHEMICAL CALCULATIONS|CONFORMATIONAL EQUILIBRIUM|1,1,1-TRIFLUORO-N-(1,1,2,2,2-PENTAFLUOROETHYL) METHANESULFINIMIDOYL CHLORIDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18180,"idioma_id":5,"titulo":"Inducción de ciclos estrales en vacas lecheras con anestro posparto utilizando progesterona y hormonas gonadotroficas","resumen":"El objetivo del presente estudio fue inducir la ciclicidad de vacas lecheras en anestro posparto tras la aplicación de dos extractos gonadotróficos. Se trabajo con 7 planteles, en los cuales se seleccionaron 89 vacas en anestro con más 60 días de paridas, ubicados en la Región de Los Ríos de Chile. Las vacas seleccionadas fueron distribuidas aleatoriamente en 3 grupos; dos recibieron un dispositivo intravaginal con 1,38 g de progesterona por 7 días, uno de ellos recibió 2 dosis de 50 mg de HAP (extracto de pituitaria anterior equina) al 7º y 8º día, y el otro grupo recibió 400 UI de eCG (gonadotrofina coriónica equina) al 7º día. El tercer grupo fue el control sin tratamiento. La presentación de celos fue estadísticamente mayor (P<0,05) en los grupos que recibieron los tratamientos gonadotróficos comparado con el control. Se logró reducir significativamente el lapso tratamiento primer servicio en vacas tratadas con HAP (11,8 días) y eCG (13 días) respecto al control (34,2 días). Los porcentajes de ovulación en vacas tratadas con HAP (48,4%) y eCG (56,7%) superaron estadísticamente (P<0,05) a los controles (14,3%). Al analizar el lapso tratamiento concepción, no se encontró diferencias estadísticamente significativas entre los grupos tratados con HAP (16,7 días), con eCG (20,8 días) y los controles (31,7 días). Se logró mejorar significativamente el porcentaje de preñez total a los 25 días de concluido el tratamiento en las vacas tratadas con HAP, 35,5%, respecto al control, 10,7%. Los tratamientos gonadotróficos podrían ser herramientas útiles en el manejo reproductivo del anestro posparto en vacas lecheras.","palabras_clave":"VACA LECHERA|ANESTRO POSPARTO|TRATAMIENTO GONADOTROFICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18181,"idioma_id":5,"titulo":"Análisis de índices de confort térmico   para las condiciones de la República Argentina,  comenzando por Ciudad Autónoma   de Buenos Aires y Provincia de Buenos Aires","resumen":"El objetivo de este trabajo es analizar distintos índices de confort térmico utilizando los métodos fisiológicos de confort de Fanger, el índice de nueva temperatura efectiva y&nbsp; los métodos adaptativos de Humphreys, Auluciems y De Dear; contribuir a la eficiencia energética y aprovechar mejor los recursos energéticos en un contexto de calentamiento global y cambio climático. Este análisis permitirá establecer el confort térmico para proyectos de edificaciones y plantas industriales a partir de datos climatológicos.Por medio del análisis comparativo de los distintos índices, y mediante la confección de mapas temáticos determinados por interpolación usando los datos climáticos de las estaciones del Servicio Meteorológico Nacional de 26 ciudades, se podrá disponer de las condiciones de confort y psicométricas que establecen las normas para el bienestar humano y se elaborarán mapas que identifiquen las condiciones de confort. Esto permitirá establecer estrategias bioclimáticas de climatización para ejecutar proyectos de máxima eficiencia energética.","palabras_clave":"Confort|Térmico|Modelos|Adaptativos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18182,"idioma_id":4,"titulo":"A labeled argumentation framework","resumen":"To increase the expressivity of an argumentation formalism, we propose adding meta-level information to the arguments in the form of labels representing quantifiable data such as reliability degree, strength measure, skill, time availability, or any other feature about arguments. The extra information attached to an argument is then used in the acceptability determination process.We present a Labeled Argumentation Framework (LAF), combining the knowledge representation capabilities provided by the Argument Interchange Format (AIF) with an Algebra of Argumentation Labels, enabling us to handle the labels associated with the arguments. These labels are propagated through an argumentative graph according to the relations of support, conflict, and aggregation between arguments. Through this process we obtain final labels attached to the arguments that are useful to determine their acceptability.","palabras_clave":"ARGUMENTATION|META-LEVEL INFORMATION|ALGEBRA OF ARGUMENTATION LABELS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18183,"idioma_id":4,"titulo":"An individual task meta-analysis of social cognition in euthymic bipolar disorders","resumen":"OBJECTIVE:  Social cognition has been shown to be affected in bipolar disorders, even during euthymia. However, the social cognitive profile of this group of disorders remains to be ascertained, given that such a broad neuropsychological construct has not been systematically examined in bipolar subjects across different tasks. The aim of this study was to quantify the magnitude of patient-control differences for distinct social cognition assessment instruments: the Hinting Task, the Eyes Test, Faux Pas, the Mayer-Salovey-Caruso Emotional Intelligence Test, and emotional labeling using visual stimuli.  METHOD:  Effect sizes were extracted from studies chosen according to more stringent criteria than previously used in systematic reviews on the topic and pooled by means of meta-analytical procedures.  RESULTS:  No significant patient-control differences were found for the recognition of three basic emotions (happiness, sadness, and anger). Small but significant effect sizes favoring healthy controls (Hedges&#1523; g<0.5) were noted for emotional intelligence, the Hinting Task, the Eyes Test, and the recognition of fear, disgust, and surprise. A medium effect size (Hedges´ g=0.58) was noted for the Faux Pas Test.  LIMITATIONS:  The possible effects of other neurocognitive impairments on social cognitive performance could not be explored.  CONCLUSION:  On average, small-to-moderate differences may exist between euthymic bipolar disorder subjects and healthy controls regarding social cognitive performance, with mental state decoding being more preserved than mental state reasoning. The influence of clinical and neurocognitive variables, which may play an important role in the social cognitive outcomes of these patients, deserves further clarification.","palabras_clave":"BIPOLAR DISORDER|EUTHYMIA|SOCIAL COGNITION|META-ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18184,"idioma_id":4,"titulo":"Temperature evolution of the effective magnetic anisotropy in the MnCr2O4 spinel","resumen":"In this work, we present a study of the low temperature magnetic phases of polycrystalline MnCr2O4 spinel through dc magnetization and ferromagnetic resonance spectroscopy (FMR). Through these experiments, we determined the main characteristic temperatures: TC ~ 41K and TH ~ 18K corresponding, respectively, to the ferrimagnetic order and to the low temperature helicoidal transitions. The temperature evolution of the system is described by a phenomenological approach that considers the different terms that contribute to the free energy density. Below the Curie temperature, the FMR spectra were modeled by a cubic magnetocrystalline anisotropy to the second order, with K1 and K2 anisotropy constants that define the easy magnetization axis along the  direction. At lower temperatures, the formation of a helicoidal phase was considered by including uniaxial anisotropy axis along the [1 -1 0] propagation direction of the spiral arrange, with a Ku anisotropy constant. The values obtained from the fittings at 5K are K1=-2.3 x 10^4 erg cm-3, K2=6.4 x 10^4 erg cm-3 and Ku=7.5 x 10^4 erg cm-3.","palabras_clave":"CHROMIUM SPINEL|MAGNETIC ANISOTROPIES|FERROMAGNETIC RESONANCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18185,"idioma_id":5,"titulo":"Evaluación de Sustentabilidad de un modelo extensivo de cría bovina   en Mendoza, Argentina","resumen":"Se evaluó la sustentabilidad de un modelo extensivo de cría bovina en General Alvear, Mendoza, mediante el método multicriterio, construyéndose indicadores de sustentabilidad basados en la información suministrada por visitas a campo y entrevistas realizadas a informantes clave. Para tal fin, se consideraron aspectos ecológicos, económicos y sociales. Los principales puntos críticos observados en este modelo se encontraron en la dimensión social, debido principalmente a las fuertes limitaciones de acceso a servicios, escasa capacitación y el bajo nivel de asociatividad. Desde el punto de vista económico, si bien el nivel de ganancias es aceptable, el riesgo económico se ubica en el valor umbral por la falta de vías de comercialización, la dependencia de insumos externos y una escasa eficiencia productiva. En cuanto a la dimensión ecológica, todos los indicadores se encontraron por encima del valor umbral. Sin embargo se proponen alternativas de manejo que contribuyan a la estabilidad de los recursos, la conservación de la base forrajera, la mejora de las condiciones sociales y los logros económicos a largo plazo. Los resultados de este análisis confirman la necesidad de evaluar la sustentabilidad de los sistemas productivos mediante indicadores acordes a la realidad ganadera local.","palabras_clave":"ANALISIS MULTICRITERIO|INDICADORES SUSTENTABILIDAD|GANADERÍA EXTENSIVA|ZONAS ÁRIDAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18186,"idioma_id":4,"titulo":"The trajectory of neuropsychological dysfunctions in bipolar disorders: A critical examination of a hypothesis.","resumen":"OBJECTIVE:  The hypothesis of a progressive nature of neuropsychological deficits in bipolar disorders is often accepted as an axiom by many clinicians and researchers in the field. However, contradictory pieces of data and a number of methodological concerns put it under debate.  METHOD:  We reviewed findings from three different approaches to the study of the trajectory of cognitive features in bipolar disorders: longitudinal evaluation of cognition in affected subjects, cross-sectional neuropsychological assessment of patients belonging to different age groups, and exploration of the risk of dementia in bipolar subjects.  RESULTS:  An increased risk of developing dementia was found in bipolar subjects. However, evidence from cross-sectional studies did not show more severe cognitive deficits in patients with longer illness duration. Furthermore, longitudinal studies revealed that bipolar subjects&#1523; cognitive performance did not change between different points in time.  CONCLUSIONS:  After a thorough discussion of these findings and the limitations of the different approaches, we argue that, at present, there is no consistent evidence supporting that bipolar disorders, as a group, have a progressively deteriorating course of cognitive functions. Furthermore, we highlight the possible influence of psychotropic agents and metabolic factors on neuropsychological outcomes. Finally, we discuss the clinical implications of these findings and propose targets for forthcoming research.","palabras_clave":"BIPOLAR DISORDER|COGNITION|NEUROPROGRESSION|TEMPORAL EVOLUTION|STAGING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18187,"idioma_id":4,"titulo":"Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review","resumen":"It iswellknownthatpatientswithbipolardisorder(BD)havecognitiveimpairmentsevenduring periods ofeuthymia.However,todateitremainsunclearthemomentwhenthesedeficits onset. Therefore,theaimofthisstudywastoreviewtheevidencefocusingonthecognitivestatusofpatients with BDintheirpremorbidstageandintheir first episode.Anextensivesearchwasconductedthrough the onlinedatabasesPubmed\/PsychInfo,coveringtheperiodbetween1980and2014.Atotalof23 studies wereselectedforthereview(ninestudiesexploredpremorbidstageofpeoplewholately develop BDand14examined first-episodes inbipolarpatients).Thereisevidencethatgeneral intelligenceisnotimpairedinthepremorbidstage.Impairmentsinverbalmemory,attention,and executivefunctionstendtobepresentduringandafterthe first episode.Preliminaryevidencesuggests that thesedeficits inspecific cognitivedomainsmightprecedetheonsetofillness. ","palabras_clave":"COGNITION|MEMORY|EXECUTIVE FUNCTIONS|HIGH-RISK"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18188,"idioma_id":5,"titulo":"Escasez extraordinaria y Derecho de Aguas","resumen":"El derecho de aguas de aguas elaborado en el marco del paradigma decimonónico, todavía subyacente en la mayoría de las legislaciones de America Latina, considera  a la sequía como una situación excepcional. Pero es evidente que en muchas geografías  desérticas o semidesérticas la sequía extraordinaria y la escasez, considerada  no sólo desde el punto de vista hidrológico sino también económico y social, ha  dejado de ser la excepción para transformarse en la regla. Los sistemas clásicos previeron reglas para el manejo de la escasez ordinaria y extraordinaria pero las previstas para la escasez ordinaria son, por motivos  diversos, de escasa nula o deficiente aplicación (planificación, prioridades,  expropiación, vedas, reservas, turnado, etc.) y las de la extraordinaria no  existen, son escasas, o dejan librado casi todo al ámbito de la actividad  discrecional del administrador que recurre sistemáticamente al carácter  supuestamente excepcional de la sequía para fundar decisiones al margen de la  regla. En este contexto, no parece posible seguir manteniendo incólumes e insistiendo en la aplicación de reglas o fórmulas de administración de la escasez  ordinaria de ineficacia probada ni es posible dejar librado a la  discrecionalidad de la autoridad administrativa esta situación que no puede  considerarse más como excepcional. Se trata de construir un derecho de aguas  que para ser eficiente y eficaz gane dinamismo, adaptabilidad y legitimidad,  pero sin comprometer la legalidad, la seguridad jurídica ni la mínimima previsibilidad que configuran el Estado de derecho (Latindex)","palabras_clave":"Escasez extraordinaria|derecho de aguas |sequia |estado de excepción"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18189,"idioma_id":5,"titulo":"Mecanismos informales de asignación y reasignación de aguas públicas e ineficacia del derecho en el oeste árido argentino","resumen":"El presente trabajo tiene como objetivo principal analizar los mecanismos informales de asignación y reasignación de aguas públicas en el oeste argentino desde una concepción integral del derecho. Se revisa la práctica de los usos informales, su lógica pero ineficaz represión tanto como su regularización desde un diseño metodológico observacional no experimental basado en el uso de estrategias cualitativas. El trabajo indaga en el funcionamiento de los mecanismos y prácticas administrativas desarrollados en ausencia de ley y contra la ley, tanto a nivel legal y reglamentario como distributivo. Las conclusiones ponen de relieve las tensiones y contradicciones de estos mecanismos al amparo del sistema legal formal evidenciando una crisis tanto de eficacia como de legitimidad del derecho y del Estado administrador del agua pública.(SCOPUS\/ELSEVIER; DOAJ; PROQUEST: Environmental Science Collection; EBSCO Publishing; SWETS; AVANO; Environment Complete; WORLDCAT; AgNIC - Agriculture Network Information Center; CAB Abstracts; OPEN J-GATE; CrossRef (dx.doi.org\/10); Ryerson University Library & Archives; OAIster: The University of Illinois OAI-PMH Data Provider Registry; Open Journal Systems; PKP - The Public Knowledge Project, University of British Columbia and Simon Fraser University ; REDALYC; MENDELEY; SOCOL@AR; LATINDEX ; PERIÓDICA: índice de revistas latinamericas em ciência; CIT ? Actualidad Iberoamericana; SciELO; PERIÓDICOS CAPES - O Portal Brasileiro de Informação Científica; LIVRE; DIADORIM; SUMÁRIOS.ORG; ABEC)","palabras_clave":"ARGENTINA|EFICACIA|USOS INFORMALES|AGUA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18190,"idioma_id":4,"titulo":"Debris flows in the Andean Ranges of central Chile and Argentina triggered by 2013 summer storms: characteristics and consequences.","resumen":"In January and February 2013, heavy rainfall during local summer storms triggered a large number of landslides in the Andes Main and Frontal ranges of central Chile and Argentina (32-34º S). Most of the mass movements classify as debris flows, while rock falls and debris avalanches also occurred. The major debris flows occurred in the Maipo and Aconcagua valleys (Chile) and along the Mendoza River valley (Argentina). The debris flows caused serious disruption to the international highway connecting both countries, local roads and produced a large impact on the population of major cities downstream, mainly due to potable water-supply cut-offs. Debris flow deposits have silt and clay particles usually ranging between 10 and 20% by weight, which favours the movement of viscous flows in short, steep lateral gullies. Most of the flows tended to channelize and the materials were deposited in alluvial fans and cones in areas with previous records of such events. This indicates that they constitute a significant hazard that may not have been properly considered in road infrastructure and potable water-supply strategies for the region. This potential hazard may become more serious due to climate change in the near future.","palabras_clave":"Debris flow|Hazard|Damages|International road"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18191,"idioma_id":5,"titulo":"Causas, características e impacto de los procesos de remoción en masa en áreas contrastantes de la región Andina","resumen":"Remociónes en masa son agentes geomorfológicos comunes en la región Andina, a veces resultando en desastres. Su ocurrencia y características son determinadas por la interacción de varios factores tales como la geología, topografía, clima y actividades antropogénicas. La comprehensión de sus características profita de estudios comparativos sobre áreas climáticas, geomorfológicas y socio-económicas contrastantes. Colombia con su clima húmedo-tropical y población densa es uno de los puntos globales de más alto riesgo de remociones en masa: los deslizamientos y flujos, accionados por eventos La Niña o actividad de volcanes glaciados, contrastan a las caídas de rocas y flujos detríticos en el árido y escasamente poblado Centro-Oeste Argentino, generalmente asociados a eventos El Niño. Terremotos han generado grandes colapsos en ambas regiones.","palabras_clave":"Region Andina|Procesos de remocion en masa|Mitigación riesgo|Deslizamientos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18192,"idioma_id":4,"titulo":"Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia","resumen":"BACKGROUND: Thioredoxin (Trx) family proteins are crucial mediators of cell functions via regulation of the thiol redox state of various key proteins and the levels of the intracellular second messenger hydrogen peroxide. Their expression, localization and functions are altered in various pathologies. Here, we have analyzed the impact of Trx family proteins in neuronal development and recovery, following hypoxia\/ischemia and reperfusion.METHODS: We have analyzed the regulation and potential functions of Trx family proteins during hypoxia\/ischemia and reoxygenation of the developing brain in both an animal and a cellular model of perinatal asphyxia. We have analyzed the distribution of 14 Trx family and related proteins in the cerebellum, striatum, and hippocampus, three areas of the rat brain that are especially susceptible to hypoxia. Using SH-SY5Y cells subjected to hypoxia and reoxygenation, we have analyzed the functions of some redoxins suggested by the animal experiment.RESULTS AND CONCLUSIONS: We have described\/discovered a complex, cell-type and tissue-specific expression pattern following the hypoxia\/ischemia and reoxygenation. Particularly, Grx2 and Trx1 showed distinct changes during tissue recovery following hypoxia\/ischemia and reoxygenation. Silencing of these proteins in SH-SY5Y cells subjected to hypoxia-reoxygenation confirmed that these proteins are required to maintain the normal neuronal phenotype.GENERAL SIGNIFICANCE: These findings demonstrate the significance of redox signaling in cellular pathways. Grx2 and Trx1 contribute significantly to neuronal integrity and could be clinically relevant in neuronal damage following perinatal asphyxia and other neuronal disorders.","palabras_clave":"COMMON CAROTID ARTERY OCCLUSION|THIOREDOXIN FAMILY OF PROTEINS|HYPOXIA|REOXYGENATION|PERINATAL ASPHYXIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18194,"idioma_id":4,"titulo":"Effect of arsenic on the rhizosphere colonization potential of two plant growth-promoting bacteria used as biological inoculants","resumen":"Bacterial ability to colonize the rhizosphere of plants in arsenic (As) contaminated soils is highly important for symbiotic and free-living plant growth-promoting rhizobacteria (PGPR) used as inoculants, since they can contribute to enhance plant As tolerance and limit metalloid uptake by plants. The aim of this work was to study the effect of As on growth, exopolysaccharide (EPS) production, biofilm formation and motility of two strains used as soybean inoculants, Bradyrhizobium japonicum E109 and Azospirillum brasilense Az39. The metabolism of arsenate (As(V)) and arsenite (As(III)) and their removal and\/or possible accumulation were also evaluated. The behavior of both bacteria under As treatment was compared and discussed in relation to their potential for colonizing plant rhizosphere with high content of the metalloid. B. japonicum E109 growth was reduced with As(III) concentration from 10 &#956;M while A. brasilense Az39 showed a reduction of growth with As(III) from 500 &#956;M. EPS and biofilm production increased significantly under 25 &#956;M As(III) for both strains. Moreover, this was more notorious for Azospirillum under 500 &#956;M As(III), where motility was seriously affected. Both bacterial strains showed a similar ability to reduce As(V). However, Azospirillum was able to oxidize more As(III) (around 53%) than Bradyrhizobium (17%). In addition, both strains accumulated As in cell biomass. The behavior of Azospirillum under As treatments suggests that this strain would be able to colonize efficiently As contaminated soils. In this way, inoculation with A. brasilense Az39 would positively contribute to promoting growth of different plant species under As treatment","palabras_clave":"soybean|arsenic|inoculants|biofilm"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18195,"idioma_id":5,"titulo":"Aprendiendo a seleccionar alimentos en el recreo escolar","resumen":"El objetivo de este trabajo es dar a conocer una propuesta que brinde a los estudiantesherramientas que los capacite para seleccionar, en función de sus necesidadesnutricionales, los alimentos que consumen en el recreo escolar. Se empleará,durante el desarrollo del trabajo, el análisis de la información nutricional que seencuentra en las etiquetas y los envases de los alimentos industrializados. La propuestaconsiste en presentar al alumnado una guía de actividades que incluye contenidosreferidos a alimentación saludable, información nutricional de etiquetas yopciones de meriendas saludables para el recreo escolar.","palabras_clave":"APRENDIZAJE|ALIMENTACIÓN|ETIQUETAS|INFORMACIÓN NUTRICIONAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18196,"idioma_id":5,"titulo":"Breve análisis de las políticas sociales en la Argentina neoliberal: focalización y clientelismo como criterios de distribución de los recursos públicos","resumen":"    La postura neoliberal sobre  las políticas sociales acepta la conveniencia de satisfacer las necesidades  básicas de aquellas personas que tienen el status de beneficiarios ?legales? de  determinados programas, ajustada al ordenamiento jurídico vigente, pero sin  reconocer la obligatoriedad de la prestación pública como un derecho puesto  que, para esta visión, la asistencia social es incompatible con los derechos  humanos ya que la redistribución de la riqueza por parte del Estado propende al  quiebre de la libre espontaneidad del mercado y a la subversión del  ordenamiento socioeconómico liberal impuesto por la globalización económica.    Frente a esta postura, la  justificación de las políticas sociales sobre la base del concepto amplio de  ciudadanía , en cuanto piso mínimo igualitario, que permite un accionar  reformista capaz de consolidar un esquema de reivindicaciones por parte del  Estado respecto de una serie extendida de bienes colectivos de acuerdo con las  necesidades ciudadanas, que permitan el reconocimiento de los derechos humanos,  lo cual no equivale sólo a brindar una asistencia imprescindible y acotada a  los fragmentos más vulnerables de la sociedad, sino a socializar de manera  concreta los ingresos y productos de la sociedad generados colectivamente.    En una sociedad segmentada, con  fuerte precarización y con una distribución desigual del empleo, la propiedad y  las rentas, resulta imperioso reivindicar el derecho humano a una vida digna  con acceso a bienes y rentas suficientes para evitar la exclusión y la pobreza,  respetando la universalidad e incondicionalidad de la prestación, y ampliando  los derechos sociales y la plena ciudadana social con una perspectiva  igualitaria.    En el fondo, el intento de  este trabajo ha siso exponer las dimensiones compleja del proceso de  transferencia de ingresos de los sectores mayoritarios a los sectores  económicos de concentración del capital&nbsp;  de la sociedad argentina de las últimas dos décadas, por su impacto en  el desarrollo de sus derechos humanos en relación con la democracia política,  la equidad económica y la justicia social.    En este contexto, partimos de  la idea de que las políticas sociales universalizadoras e incondicionales son  las únicas que pueden garantizar la provisión de bienestar de tal manera que  las personas puedan tener resuelto una serie de derechos y puedan ser libres en  una república democrática. En otras palabras, que tengan derecho a una  existencia material que no dependa de otros individuos o del aparato  clientelar.     En nuestra historia nacional,  vimos como las variantes neoliberales de todo tipo, cuando les ha tocado  gobernar, incluida la actual versión populista, han ejecutado políticas  presupuestarias orientadas a administrar la pobreza y la desigualdad, no a  reducirla ni a eliminarla.     Por ello, es necesario aplicar  políticas sociales y normativas orientadas hacia el logro de una provisión de  bienestar universal e incondicional para todos los ciudadanos como un derecho  fundamental, y al mismo tiempo generar medidas que impidan que la tolerable  apropiación y acumulación de riqueza sirva para el establecimiento de poderes  fácticos capaces de actuar en defensa de sus intereses corporativos sobre el  bienestar de las mayorías.  ","palabras_clave":"POLÍTICAS FOCALIZADAS|NEOLIBERALISMO|GASTO PÚBLICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18198,"idioma_id":4,"titulo":"Evaluation of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry for species identification of Nonfermenting Gram-Negative Bacilli","resumen":"Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) to identify 396 Nonfermenting Gram-Negative Bacilli clinical isolates was evaluated in comparison with conventional phenotypic tests and\/or molecular methods. MALDI-TOF MS identified to species level 256 isolates and to genus or complex level 112 isolates. It identified 29 genera including uncommon species.","palabras_clave":"Identification|MALDI-TOF MS|Nonfermenting Gram-Negative Bacilli|Uncommon species"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18199,"idioma_id":5,"titulo":"Motivación y tareas escolares. Investigando en el último año de la escuela secundaria.","resumen":"Este artículo se focaliza particularmente en mostrar un diseño de investigación que permite estudiar las relaciones entre la motivación para aprender de los estudiantes que están finalizando la escuela secundaria y las tareas escolares que se desarrollan en los contextos naturales de clase. La investigación se desarrolló partir de Diseños de Investigación descriptivos y correlacionales transeccionales, a partir de diferentes análisis de datos complementarios.Se realizaron tres estudios empíricos. El primer estudio constituyó una investigación descriptiva que permite acceder al conocimiento sobre las metas que eligen los estudiantes del último año de nivel medio para aprender, cuando se enfrentan a distintas situaciones educativas. El segundo estudio permite indagar las características de las tareas escolares que promueven aprendizajes en el aula del último año de la escuela secundaria. El tercer estudio posibilita investigar la asociación entre las tareas escolares según el grado de interés por aprender que éstas promueven, con las siguientes variables: el género estudiantil y la orientación disciplinar de cada una de las escuelas secundarias estudiadas.Se trabajó con estudiantes del último año de la secundaria en cuatro escuelas públicas de la ciudad Río Cuarto, Córdoba, Argentina. Se realizaron observaciones de las tareas escolares que se proponen en contexto naturales de clase; y también se estudiaron las tareas que promueven interés para aprender asociadas al género de los estudiantes, las materias escolares y la orientación disciplinar de las escuelas secundarias.","palabras_clave":"Motivación para aprender|Tareas escolares|Último año de la escuela secundaria"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18200,"idioma_id":4,"titulo":"Environmental phosphate differentially affects virulence phenotypes of uropathogenic Escherichia coli isolates causative of prostatitis","resumen":"K-12 Escherichia coli cells grown in static media containing a critical   phosphate (Pi) concentration ³25mM maintained a high   polyphosphate (polyP) level in stationary phase, impairing biofilm formation, a   phenomenon that is triggered by polyP degradation. Pi concentration in human   urine is fluctuated according to health state. Here, the influence of   environmental Pi concentration on the occurrence of virulence traits in   uropathogenic E. coli (UPEC) isolated from acute prostatitis patients was   evaluated. After a first screening, three isolates were selected according to   differential biofilm formation profiles depending on media Pi concentration. For   each, biofilm positive and negative conditions were established. Regardless of   the isolate, biofilm formation capacity was accompanied with curli and cellulose   production, swimming motility and expression of some key virulence factors   associated with adhesion. When the selected isolates were grown in their   non-biofilm-forming condition, low concentrations of nalidixic acid and   ciprofloxacin induced biofilm formation. Interestingly, similar to laboratory   strains, polyP degradation induced biofilm formation in the selected isolates.   Results sustains the complexity of pathogenic E. coli in response to   environmental Pi and the importance of polyP metabolism as an aspect involved in   biofilm formation in both clinical isolates and laboratory strains.","palabras_clave":"UPEC|prostatitis|polyphosphate|biofilm"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18201,"idioma_id":5,"titulo":"PROBLEMATIZACIONES EN TORNO A LA TEORÍA DE LA EDUCACIÓN FÍSICA  LA PSICOLOGÍA Y SU INFLUENCIA EN LOS DISCURSOS DE LA EDUCACIÓN FÍSICA","resumen":"Es sabida la influencia que el discurso de la Psicología ha tenido sobre la constitución y consolidación del campo de la Educación Física. Sin embargo, el tema lejos de agotarse, sigue presente en los discursos actuales. En este trabajo se presenta una hipótesis que dará lugar a una serie de publicaciones en el marco de la teoría de la Educación Corporal. La hipótesis es que los discursos de la Educación Física han sido influenciados por los discursos de la Psicología y que no han explorado la potencialidad del psicoanálisis. Analizamos la conformación del campo de la Educación Física y la irrupción del discurso de la psicología, sus condiciones de posibilidad y sus argumentos de ?verdad? y proponemos la necesidad de revisar esta relación.","palabras_clave":"Teoría|Educación Física|Psicología"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18202,"idioma_id":4,"titulo":"Potential of biological control agents against Tuta absoluta (Lepidoptera: Gelechiidae): current knowledge in Argentina","resumen":"Pest suppression through biological control seeks to maximize the action of the pest?s natural  enemies with the goal of reducing pesticide use. We present a summary of  published studies and original findings on several entomophagous species as biocontrol  agents of Tuta absoluta (Meyrick,  1917) (Lepidoptera: Gelechiidae), a  key pest of tomato crops in Argentina, with the aim to select  potential candidates for its management. Spontaneously occurring T.  absoluta egg parasitism was lower than that inflicted by the larval parasitoids  Dineulophus phthorimaeae (De Santis, 1983) (Hymenoptera: Eulophidae) and  Pseudapanteles dignus (Muesebeck, 1938) (Hymenoptera: Braconidae). These  parasitoids exhibit important life history traits in laboratory conditions and produce  relevant amounts of T. absoluta  mortality in the field. Surveys carried out in Northwestern and Buenos Aires  provinces, Argentina, revealed that D. phthorimaeae and P. dignus coexist in  tomato and eggplant  crops; T. absoluta-P. dignus interaction  is also found on other non-cultivated solanaceous species present in horticultural  farms. In addition, studies are currently under way to determine the predation  ability of Zelus obscuridorsis  (Stål, 1860)  (Hemiptera: Reduviidae) on both larvae and adults of the pest. Finally, we discuss  the prospects for implementing experimental augmentative releases of P. dignus to control the pest, a  candidate selected considering various positive biological characteristics and because  of its simple mass production and manipulation compared with other antagonists  of T. absoluta.","palabras_clave":"Biocontrol|Lycopersicum esculentum|Dineulophus phthorimaeae|parasitoid|predator|South American tomato leafminer"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18203,"idioma_id":4,"titulo":"Pharmacological mechanism underlying the antinociceptive activity of vanillic acid","resumen":"Vanillic acid is found at high concentrations in many plants used in traditional medicine. It has been associated with a variety of pharmacologic activities such as carcinogenesis inhibition, apoptosis and inflammation; however, it has become most popular for its pleasant creamy odor. Since there are few reports concerning the antinociceptive activity of this phenolic compound, the aim of this work was to study this activity in in vivo animal models. Vanillic acid was administered by the intraperitoneal route producing a dose-dependent inhibition of the acetic acid-induced writhing response (ED50: 9.3 mg\/Kg). The antinociceptive activity was inhibited by the pretreatment with ondansetron and yohimbine, indicating that the serotoninergic and adrenergic systems could participate in the mechanism underlying the analgesic activity of vanillic acid. This compound was also demonstrated to interact with ASICs (Acid-sensing Ion Channels) as well as with TPRV1, TRPA1, TRPM8 receptors in vivo. Furthermore, vanillic acid did not interfere with the locomotor function or motor coordination. The plasmatic phenolic content, analyzed by HPLC, showed that its t1\/2 and AUC were 0.123 h and 1.38 µg.h\/mL; respectively. In conclusion, vanillic acid might represent a potential therapeutic option for the treatment of pain.","palabras_clave":"vanillic acid|vascular permeability|antinociceptive activity|pharmacokinetic profile"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18204,"idioma_id":4,"titulo":"MODEL ISOTHERMAL OF THE EQUILIBRIUM OF THE HERBICIDE 2,4-DICHLOROPHENOXYACETIC ACID IN WATERY PHASE ON SOIL WITH HIGH CONTAINED ORGANIC MATTER","resumen":"          Adsorption isotherm of  2,4-dichlorophenoxyacetic acid (2,4-D) herbicide on soil high in organic matter  (used in rice cultivation) from determined batch test. The effects of contact  time, initial concentration were investigated. The adsorption equilibrium data  were processed in accordance with three most widely used adsorption isoterms:  Freundlich, Langmuir and Temkin isoterm models. The equilibrium data were best  represented by Freundlich isoterm model, showing higher Kd values reveal that  adsorption is strong. These results are related to thedifferent content and nature of soil organic matter.  ","palabras_clave":"HERBICIDE|CONTAMINATION|WATER|ADSORPTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18205,"idioma_id":5,"titulo":"'Neuropéptido Y (NPY) Determinación inmunohistoquímica en duodeno de fetos de caballo en la etapa intermedia de la gestación'","resumen":"Las hormonas regulan diferentes funciones del organismo entre las que se incluyen aquellas vinculadas con el aparato digestivo, lo que resulta interesante por la asociación de éste con distintas etapas del desarrollo del individuo. Para poder aportar nuevos conocimientos, muchos son los aspectos a considerar como por ejemplo el estudio de las sustancias químicas involucradas en el proceso alimentario, como las hormonas gastrointestinales. El objetivo es determinar la presencia de Neuropéptido Y (NPY) en  duodeno de fetos de caballo en etapas intermedias del desarrollo. Se utilizaron fetos correspondientes a etapas intermedias de la gestación (periodo G2) obtenidos del frigorífico Aimar-Río Cuarto. Se tomaron muestras de duodeno que fueron fijadas en formol bufferado incluidas en parafina y procesadas con la técnica histológica convencional. Para la determinación del NPY se utilizó la técnica de inmunohistoquímica con anticuerpos comerciales. En las muestras de fetos de periodo G2 se observó la presencia de NPY tanto en epitelio de revestimiento intestinal como en el interior de las glándulas intestinales. El NPY está presente en duodeno, tanto en  los enterocitos del epitelio de revestimiento como en las  glándulas intestinales. Este hallazgo permitirá aportar conocimientos básicos para futuros estudios fisiológicos relacionados con el rol que cumple el NPY en la especie en estudio.","palabras_clave":"NPY|INMUNOHISTOQUIMICA|FETOS|CABALLO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18206,"idioma_id":4,"titulo":"Comparison of Different In Vitro Tests to Detect Cryptococcus neoformans Not Susceptible to Amphotericin B","resumen":"Comparison of Different In Vitro Tests to Detect Cryptococcus neoformans Not Susceptible to Amphotericin B","palabras_clave":"CRYPTOCOCCUS|TIME KILL CURVES|AMPHOTERICIN B|RESISTANCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18207,"idioma_id":4,"titulo":"A silencing reporter and a whole-plant agroinfiltration transient assay to evaluate the potential of an hpRNA construct to induce multiple tospovirus resistance","resumen":"Tospoviruses are devastating plant viruses causing severe economic losses in a diverse range of crops worldwide. Here, we describe the development and evaluation of an RNA interference (RNAi) broad-spectrum virus resistance strategy based on a unique and short hairpin-RNA-generating construct (pNhpRNA). This construct was designed from a region of the nucleocapsid gene (N) of Tomato spotted wilt virus (TSWV) that showed a high sequence identity to the corresponding region in the related species Groundnut ringspot virus (GRSV) and Tomato chlorotic spot virus (TCSV).To test the effectiveness of the pNhpRNA construct, we developed a silencing reporter assay based on three fusion proteins in which the complete viral N gene sequence from each of the three tospoviruses was fused in frame to the green fluorescent protein (GFP) sequence. Co-agroinoculation of these constructs with pNhpRNA into leaves of Nicotiana benthamiana resulted in a strong silencing phenotype determined by GFP decay and suppression of the three N genes at the RNA and protein levels. To test the potential of the pNhpRNA construct to generate virus-resistant plants, we infiltrated the whole shoots of N. benthamiana with pNhpRNA. When these infiltrated plants were mechanically inoculated with the mentioned viruses 100, 70, and 60 % resistance phenotypes to TSWV, GRSV, and TCSV, respectively, were observed. The induction of a broad tospovirus resistance with a simple construct and a minimized off-target effect are the main contributions of pNhpRNA.","palabras_clave":"BROAD-SPECTRUM RESISTANCE|NICOTIANA BENTHAMIANA|TOBACCO|TRANSGENE EVALUATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18208,"idioma_id":4,"titulo":"The 18S-25S ribosomal RNA unit of yerba mate (Ilex paraguariensis A. St.-Hil.)","resumen":"We present the first report of the transcribed 18S-25S rDNA unit of the South-American crop Ilex paraguariensis. This tree is consumed as an infusion named ?mate?. NGS data was assembled, referenceannotated and further characterized. The assembled consensus sequence of the complete transcribed rDNA unit is 6961 nt, with a coverage of ~18,646X and 99.3% of global sequence similarity. The transcribed 18S and 25S rDNA genes of yerba mate are the first in the genus to be characterized, combined to the 5.8S that is identical to the consensus sequence of Ilex. The ITS1 and the ITS2 display species-specific regions, useful to differentiate yerba mate from adulterant taxa of the manufactured product. A replication slippage process seems significant in the evolution of the ITS in Ilex. The 5ETS consists in SR1, that encloses a large inverted repeat\/hairpin region, and SR2 which is a high homology region in the Asterids clade and embrace six distinctive inverted repeat\/hairpin segments. The 3ETS presents a pyrimidine-rich block associated to transcription termination, mirror-like palindromes and repetitive segments, all networking at the secondary structure level. This information will be helpful in leading future studies in the molecular evolution characterization of this crop and related species of Ilex.","palabras_clave":"AQUIFOLIACEAE|ILEX|NEXT-GENERATION SEQUENCING|MOLECULAR CHARACTERIZATION|RDNA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18209,"idioma_id":4,"titulo":"Quantifying higher-order correlations in a neuronal pool","resumen":"Recent experiments involving a relatively large population of  neurons have shown a very significant amount of higher-order  correlations. However, little is known of how these affect the  integration and firing behavior of a population of neurons beyond the  second order statistics. To investigate how higher-order inputs  statistics can shape beyond pairwise spike correlations and affect  information coding in the brain, we consider a neuronal pool where each  neuron fires stochastically. We develop a simple mathematically tractable  model that makes it feasible to account for higher-order spike  correlations in a neuronal pool with highly interconnected common inputs  beyond second order statistics. In our model, correlations between  neurons appear from q-Gaussian inputs into threshold neurons. The  approach constitutes the natural extension of the Dichotomized Gaussian  model, where the inputs to the model are just Gaussian distributed and  therefore have no input interactions beyond second order. We obtain an  exact analytical expression for the joint distribution of firing,  quantifying the degree of higher-order spike correlations, truly  emphasizing the functional aspects of higher-order statistics, as we  account for beyond second order inputs correlations seen by each neuron  within the pool. We determine how higher-order correlations depend on the  interaction structure of the input, showing that the joint distribution  of firing is skewed as the parameter q increases inducing larger  excursions of synchronized spikes. We show how input nonlinearities can  shape higher-order correlations and enhance coding performance by neural  populations.","palabras_clave":"Information coding in the brain|Higher-order inputs statistics|Mathematically tractable model|Joint distribution of firing"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18210,"idioma_id":4,"titulo":"Differential Susceptibility of Conyza bonariensis Biotypes to Glyphosate and ALS-Inhibiting Herbicides in Argentina","resumen":"The aim of this study was to compare control of three stages biotypes (rosette, bolting, and reproductivestage) of Conyza bonariensis glyphosate susceptible biotype (S) and tolerant biotype (T) toglyphosate with glyphosate and mixtures of acetolactate synthase (ALS)-inhibiting. For glyphosate,the dose-response curves confirmed that injury of the biotype T relative to biotype S was significantlylower for both rosette and bolting stages. Resistance index (RI) for this herbicide was approximately4 for both weed stages. At bolting, for both biotypes doses much higher than the recommendeddose were required. For acetolactate synthase (ALS)-inhibiting herbicides, at the rosettestage, control of both biotypes was excellent with doses significantly lower than the recommendedrate. All herbicides within this group showed a very low I50 relative to the recommendedrate. These results indicate that biotypes difficult to control with glyphosate at the rosette andbolting stage may be controlled using acetolacte synthase (ALS)-inhibiting herbicides. Control forthe reproductive stage was poor. A management program based on the combination of glyphosatewith pre- and post-emergence acetolactate synthase (ALS) herbicides may be effective to controlthe weed.","palabras_clave":"Glyphosate|Horseweed|Residual Control|Herbicide Tolerance"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18211,"idioma_id":4,"titulo":"Expansion of myeloid-derived suppressor cells with arginase  activity lasts longer in aged than in young mice after CpG-ODN  plus IFA treatment","resumen":"As we age, the homeostatic function of many systems in the body, such as the immune function declines, which in turn contributes to augment susceptibility to disease. Here we describe that challenging aged mice with synthetic oligodeoxynucleotides containing unmethylated cytosine guanine motifs (CpG-ODN) emulsified in incomplete Freund´s adjuvant (IFA), (CpG-ODN+IFA) an inflammatory stimulus, led to the expansion of CD11b+Gr1+ myeloid cells with augmented expression of CD124 and CD31. These myeloid cells lasted longer in the spleen of aged mice than in their younger counterparts after CpG-ODN+IFA treatmen and were capable of suppressing T cell proliferative response by arginase induction. Myeloid cells from aged CpG-ODN+IFA-treated mice presented increased arginase-1 expression and enzyme activity. In addition, we found a different requirement of cytokines for arginase induction according to mice age. In myeloid cells from young treated mice, arginase-1 expression and activity is induced by the presence of each IL-4 or IL-6 in their extracellular medium, unlike myeloid cells from aged treated mice which need the presence of both IL-4 and IL-6 together for arginase induction and suppressor function.","palabras_clave":"AGING|MYELOID-DERIVED SUPPRESSOR CELLS|ARGINASE|CPG-ODN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18212,"idioma_id":4,"titulo":"Distribution of Action Movements (DAM): A Descriptor for Human Action Recognition","resumen":"Human action recognition from skeletal data is an impor-tant and active area of research in which the state of the arthas not yet achieved near-perfect accuracy on many well-known datasets. In this paper, we introduce the Distributionof Action Movements Descriptor, a novel action descriptorbased on the distribution of the directions of the motions ofthe joints between frames, over the set of all possible mo-tions in the dataset. The descriptor is computed as a normal-ized histogram over a set of representative directions of thejoints, which are in turn obtained via clustering. While thedescriptor is global in the sense that it represents the overalldistribution of movement directions of an action, it is able topartially retain its temporal structure by applying a window-ing scheme.The descriptor, together with a standard classifier, out-performs several state-of-the-art techniques on many well-known datasets.","palabras_clave":"HUMAN ACTION RECOGNITION|DESCRIPTOR|PROBSOM|MSRC12|ACTION3D"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18213,"idioma_id":4,"titulo":"Enhancement of Photophysical and Photosensitizing Properties of Flavin Adenine Dinucleotide by Mutagenesis of the C-Terminal Extension of a Bacterial Flavodoxin Reductase","resumen":"The role of the mobile C-terminal extension present in Rhodobacter capsulatus ferredoxin?NADP(H) reductase (RcFPR) was evaluated using steady-state and dynamic spectroscopies for both intrinsic Trp and FAD in a series of mutants in the absence of NADP(H). Deletion of the six C-terminal amino acids beyond Ala266 was combined with the replacement A266Y to emulate the structure of plastidic reductases. Our results show that these modifications of the wild-type RcFPR produce subtle global conformational changes, but strongly reduce the local rigidity of the FAD-binding pocket, exposing the isoalloxazine ring to the solvent. Thus, the ultrafast charge-transfer quenching of 1FAD* by the conserved Tyr66 residue was absent in the mutant series, producing enhancement of the excited singlet- and triplet-state properties of FAD. This work highlights the delicate balance of the specific interactions between FAD and the surrounding amino acids, and how the functionality and\/or photostability of redox flavoproteins can be modified.","palabras_clave":"FLAVIN TRIPLET STATE|FLAVOPROTEINS|FLUORESCENCE|OXIDOREDUCTASES|SINGLET OXYGEN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18214,"idioma_id":5,"titulo":"Papas fortificadas con Ca y vitamina C conservadas por osmodehidrocongelación y envasadas en atmósfera modificada","resumen":"En el presente trabajo se fortificaron cubos de papas con calcio y vitamina C, por osmodehidrocongelación. Este proceso consiste en un proceso combinado en el que se produce una deshidratación parcial del producto al sumergirlo en una solución concentrada de solutos  y posterior congelación. Por consiguiente, se reduce la formación de cristales de hielo y se produce un menor daño a la estructura. Además la carga térmica a extraer es menor respecto del proceso de congelación sin pretratamiento osmótico logrando un importante ahorro de energía y un producto de menor volumen.  La deshidratación por pulsos de vacío permitió impregnar con calcio y vitamina C el producto a concentraciones suficientes que permiten considerarlo como un alimento fortificado. El envasado con atmósfera modificada en bolsas de material trilaminado, polietileno-aluminio-polietileno permitió conservar las características nutricionales (vitamina C y calcio), así como también, su estabilidad al deterioro microbiano en un lapso de 180 días.","palabras_clave":"ALIMENTOS FORTIFICADOS|OSMODEHIDROCONGELACIÓN|IMPREGNACIÓN CON CALCIO|IMPREGNACIÓN CON VITAMINA C"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18215,"idioma_id":4,"titulo":"Toughened polystyrene nanoparticles through high-solids miniemulsion polymerization","resumen":"Polystyrene nanoparticles toughened with polybutadiene were synthesized by miniemulsion polymerization of 50 % solids content. The effects of recipes and reaction conditions on the polymerization kinetics, polymer microstructure, particle morphology, and mechanical properties of the produced thermoplastic materials, are discussed. The final material characteristics are strongly dependant on the chemical nature of the employed initiator, and an interpretation for the observed effects is presented. The obtained nanostructured polystyrenes exhibit mechanical properties similar to those of the commercial HIPS, but with the typical advantages of polymerizations in disperse medium such as low environmental impact, high monomer conversion, and fast heat transfer. ","palabras_clave":"ATOMIC FORCE MICROSCOPY|HIGH-SOLIDS CONTENT|MINIEMULSION POLYMERIZATION|TOUGHENED POLYSTYRENE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18216,"idioma_id":4,"titulo":"Arsenic in porewaters of the unsaturated zone of an Argentinean watershed. Adsorption and competition with carbonate as important processes that regulate its concentration","resumen":"The arsenic (As) concentration in porewaters of the unsaturated (vadose) zoneof a watershed located in the Chaco-Pampean Plain of Argentina was investigated. A water displacement method using carbon tetrachloride was applied to the sediments in order to obtain the water samples, which could not be obtained by a simple high-speed centrifugationmethod. The CD-MUSIC surface complexation model was applied to calculate arsenate adsorption on sediments, arsenate Concentration in porewaters in contact with the sediments and effects of carbonate. Ferrihydrite was considered to represent the active adsorbing material in the sediments. Therefore, proton adsorption (surface charge) data and arsenate adsorption isotherms obtained with a synthetic ferrihydrite were used to calibrate the CD-MUSIC model. Arsenate and carbonate concentrations in the studied porewaters were positively correlated. The model was able to predict As concentration within a factor of two in most samples. Carbonate affects As concentration by competing with arsenate species for adsorption sites on the mineral surface. As it occurs with groundwater samples of the saturated zone in many aquifers, this article shows for the first time that adsorption?desorption processes also seem to control As concentration in oxic porewaters of theunsaturated zone.","palabras_clave":"arsenate|aquifer|surface complexation model|arsenic control"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18217,"idioma_id":4,"titulo":"Leaf traits related to productivity in Populus deltoides during the post flooding period","resumen":"              Flooding stress induces changes in trees at  plant and leaf level that can reduce growth and productivity. In this work, we  explored changes in leaf traits related to productivity during the  post-flooding period in three poplar clones with different degrees of flooding  sensibility. Our hypothesis was that changes in leaf traits could lead to a  higher photosynthetic activity in the post-flooding period to compensate for  the reduction in carbon fixation under flooding.              Plants were grown in pots in a greenhouse.  Flooding was induced by filling the pots with tap water up to 5 cm over the  surface soil for 28 days. After this period, flooding ended and plant recovery  was followed for 44 days.              Flooding decreased total leaf area, stomatal  conductance and photosynthetic rate, but leaf size, stomatal, leaf area,  chlorophyll and Rubisco content were not affected. Stomatal index was reduced  in one clone and leaf thickness was increased in another one. During the  post-flooding period, the formerly flooded plants of all clones produced leaves  with increased area and thickness compared to the control plants, but specific  leaf area and chlorophyll and Rubisco content were not altered. Stomatal index  was only decreased in one clone. The leaves expanded in the post flooding  period did not increase their photosynthetic capacity, but had a higher water  use efficiency and a lower stomatal conductance.              The plants compensated for the reduced growth  under flooding by substituting the leaf area loss instead of increasing the  photosynthetic activity.  ","palabras_clave":"POPULUS DELTOIDES|FLOODING|LEAF TRAITS|PHOTOSYNTHESIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18218,"idioma_id":4,"titulo":"Classification of Performance in Risk-of-Falls Assessment Based on Accelerometer Data and Feature Boosting","resumen":"Abstract? Clinical assessments of risk of falls for the elder-ly are growing in relevance. This work presents a strategy for the evaluation of the collective capabilities of features and indexes, collected with accelerometers, in discriminating good and poor responses in the first two stages of the Dynamic Gait Index assessment of risk. Adaptive-boosting machine learning and cross-validation strategies are implemented to test the overall classification capabilities of these indexes, their con-sistency and coherence with the biomechanical expectations for these tests. As a result, select indexes of performance are high-lighted, and the relevance of these features and parameters to performance in these parts of the DGI assessment, as con-sistent, quantitative measures of performance, supplementary to evaluations by specialized physicians, is tested.","palabras_clave":"Feature classifiers|AdaBoost|Accelerometer"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18219,"idioma_id":4,"titulo":"High-throughput Drug Repositioning for the Discovery of New Treatments for Chagas Disease","resumen":"Despite affecting around 8 million people worldwide and representing an economic burden above $7 billion\/year, currently approved medications to treat Chagas disease are still limited to drugs, nifurtimox and benznidazole, which were developed more than 40 years ago and present important efficacy and safety limitations. Drug repositioning (i.e. finding second or further therapeutic indications for known drugs) hasraised considerable interest within the international drug development community and regulatory agencies. There are many explanations to the current interest on drug repositioning including the possibility to partially circumvent clinical trials and the consequent saving in time and resources. It has been suggested as a particular attractive approach for the development of novel therapeutics for neglected diseases, which are usually driven by public or non-profit organizations. Here we review current computer-guided approaches to drug repositioning and reports on drug repositioning stories oriented to Chagas disease, with a focus oncomputer-guided drug repurposing campaigns.","palabras_clave":"Drug repositioning|computer-guided drug repositioning|Chagas disease|high-throughput drug repurposing.|neglected diseases|indication expansion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18220,"idioma_id":4,"titulo":"Yerba maté (Ilex paraguariensis St. Hil): Chemical  and Physical  changes under different aging conditions","resumen":"The leaves of the Pitanga bush (Eugenia uniflora L.) are considered to be effective against many diseases. Extracts from Pitanga leaves have been found to show pronounced anti-inflammatory action and to have antimicrobial and antifungal activities, among other properties. In this work, extracts from Pitanga leaves were obtained by hydrodistillation and by extraction with supercritical carbon dioxide (SC-CO2) at three conditions of temperature and pressure. In the SC-CO2 extractions also were collected the components that are lost with the CO2in the exit of the system using Porapak-Q polymer trap. All extracts were analyzed by gas chromatography-mass spectrometry (GC-MS). Thirty-nine compounds were found in the extracts and twenty-six were identified. The main components identified in the extracts in decreasing quantitative order were: curzerene, germacrene B, C15H20O2 and&#946;-elemene for hydrodistillation; C15H20O2 and curzerene for SC-CO2 extracts and 3-hexen-1-ol, curzerene, C15H20O2,&#946;-elemene and germacrene B for SC-CO2 extracts captured in Porapak-Q.","palabras_clave":"YERBA MATE|AGING|CHEMICAL CHANGES|KINETIC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18221,"idioma_id":4,"titulo":"Augmented-reality and Alternative-Input System based on Simultaneous Head Position and Pose Estimation","resumen":"Abstract?This work introduces an integrated system for use in alternative-input human-machine interfaces, with poten-tial augmented-reality and assistive implementations, which estimates the field of view of a user through combinations of visual and orientation information. The proposed system de-sign is explained and justified, with specific setup and calibra-tion details. A test application was developed for the assess-ment of system capabilities and limitations. Results from this work indicate that this prototype is a successful interface, suitable for general use on small screens and portable devices. Finally, potential advantages and future work related to this layout are explored.","palabras_clave":"Human-machine interface,|Position,|Angles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18222,"idioma_id":4,"titulo":"Transmittance correlation of porous silicon multilayers used as a chemical sensor platform","resumen":"tThis work presents a system of two optical microcavities made of mesoporous silicon that have been ana-lyzed as a platform for either chemical sensing or biosensing. When a porous microcavity is exposed toan analyte, the effective refractive index of its layers change, and its optical transmittance shifts towardslower wavenumbers. We constructed a device that employs two identical porous silicon microcavities,one of them is allowed to be in contact with the analyte, whereas the other remains unexposed. The trans-mitted intensity of the system results in the integrated product of the transmittances of both multilayers,which can be approximated to the autocorrelation function of the transmittance of the microcavity. Itsvalue depends on the analyte concentration, so it can be used for sensing purposes. This results in a sensorthat requires neither a wavelength-sensitive detector nor a monochromatic source of illumination, andis robust to changes in temperature, because it only depends on the relative changes in the microcavities.The sensor?s response can be optimized by modifying the angular position of the second microcavity. Asensor based on this principle is demonstrated for isopropyl alcohol detection. The minimum concentra-tion change that can be measured is about 30 ppm, which is equivalent to a minimum measurable changeof refractive index of 5 × 10&#8722;5.","palabras_clave":"Porous Silicon|Correlation Transmittance|Chemical Sensor"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18223,"idioma_id":4,"titulo":"Metformin regulates ovarian angiogenesis and follicular development in a female Polycystic Ovary Syndrome rat model","resumen":"Polycystic Ovary Syndrome (PCOS) is a frequent pathology that affects more than 5% of women of  reproductive age. Among other heterogeneous symptoms, PCOS is characterized by abnormalities  in angiogenesis. Metformin has been introduced in the treatment of PCOS to manage insulin  resistance and hyperglycemia. Besides its metabolic effects, metformin has been shown to improve  ovulation, pregnancy and live birth rates in PCOS patients. In the present study, we used a dehydroepiandrosterone  (DHEA)-induced PCOS rat model to analyze the effect of metformin administration  on ovarian angiogenesis. We found that metformin was able to restore the increased  levels of VEGF, ANGPT1 and ANGPT1\/ANGPT2 ratio and the decreased levels of PDGFB and PDGFD  observed in the DHEA-treated rats. These effects could take place, at least in part, through a  decrease in the levels of serum insulin. We also found an improvement in follicular development,  with a lower percentage of small follicles and cysts and a higher percentage of antral follicles and  corpora lutea after metformin administration. The improvement in ovarian angiogenesis is likely  to restore the accumulation of small follicles observed in PCOS rats and to reduce cyst formation,  thus improving follicular development and the percentage of corpora lutea. These results open  new insights into the study of metformin action not only in glucose metabolism but also in ovarian  dysfunction in PCOS women","palabras_clave":"PCOS|METFORMIN|ANGIOGENIC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18224,"idioma_id":4,"titulo":"A phylogeographical perspective on the ex situ conservation of Aylacostoma (Thiaridae, Gastropoda) from the High Paraná River (Argentina-Paraguay)","resumen":"Aylacostoma Spix, 1827, contains species that are the subject of focused conservation efforts under the auspices of the ´Aylacostoma Project´, the only ex situ conservation programme for freshwater gastropods in South America. Two species from the High Paraná River (Argentina-Paraguay) are included in this programme (Aylacostoma chloroticum Hylton Scott, 1954 and Aylacostoma brunneum Vogler & Peso, 2014), as their habitats have disappeared as a consequence of the filling of the Yacyretá Reservoir in the 1990s. At present, A. chloroticum is restricted to only one known wild population in a small and fragile habitat, and wild populations of A. brunneum are presumed to have gone extinct. We used partial sequences of the cytochrome oxidase subunit I gene to provide the first phylogeographical perspective on these species from a limited dataset containing representatives of several wild populations that are successfully being bred in captivity. We found low genetic diversity and two haplotypes in A. chloroticum, and absence of variation with one haplotype in A. brunneum. The reservoir´s entry zone was identified to be of great interest for conservation, and is where we suggest re-introductions and translocations should be targeted, to preserve the future evolutionary potential of the extant diversity.","palabras_clave":"HAPLOTYPES|CONSERVATION GENETICS|ENDANGERED FRESHWATER SNAILS|EVOLUTIONARILY SIGNIFICANT UNITS|MOLECULAR DIVERGENCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18225,"idioma_id":5,"titulo":"SORIANO EL OFICIO INTELECTUAL Y LA ACADEMIA","resumen":"'El artículo desarrolla la importancia del trabajo con los textos de Osvaldo Soriano en el contexto de la Universidad Pública, reivindicando su figura de intelectual, periodista y escritor'.","palabras_clave":"LECTURA|UNIVERSIDAD PÚBLICA|INTELECTUALES|DEBATES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18226,"idioma_id":4,"titulo":"Photoexcitation, Photoionization, and Photofragmentantion of CF3CF2CF2C(O)Cl Using Synchrotron Radiation between 13 and 720 eV","resumen":"Main inner shell ionization edges of gaseous CF3CF2CF2C(O)Cl, including Cl 2p, C 1s, O 1s and F 1s, have been measured in Total Ion Yield (TIY) mode by using tunable synchrotron radiation and several resonance transitions have been assigned with the help of quantum chemical calculations. Interestingly, resonance transitions observed in the C 1s region can be assigned to different carbon atoms in the molecule according to the degree of fluorine substitution. Ionic photofragmentation processes have been studied by time-of-flight mass spectrometry in the Photoelectron-Photoion-Coincidence (PEPICO) and Photoelectron-Photoion-Photoion-Coincidence (PEPIPICO) modes. These techniques revealed a memory-lost effect especially around the C 1s region, since the fragmentation events are independent on the energy range considered. Moreover, different fragmentation mechanisms were inferred from these spectra in the valence (13.0 eV - 21.0 eV) as well as in the inner (180.0 eV - 750.0 eV) electronic energy regions. The vibrational spectral features of CF3CF2CF2C(O)Cl have been interpreted in terms of a conformational equilibrium between two conformations (gauche and anti of the CC single bond with respect to the CCl one) at room temperature, as determined from quantum chemical calculations and the detailed analysis of the infrared spectrum","palabras_clave":"SYNCROTRON RADIATION|PHOTOIONIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18227,"idioma_id":4,"titulo":"Molecular Mechanism of Myoglobin Autoxidation: Insights from Computer Simulations","resumen":"Myoglobin (Mb) and hemoglobin have the biological ability to carry\/store oxygen (O2), a property which requires its heme iron atom to be in the ferrous -Fe(II)- state. However, the thermodynamically stable state in the presence of O2 is Fe(III) and thus the oxidation rate of a globin is a critical parameter related to its function. Mb has been extensively studied and many mutants have been characterized regarding its oxygen mediated oxidation (i.e., autoxidation) rates. Site directed mutants in residues 29 (B10), which shapes the distal cavity, and 64 (E7), the well-known histidine gate, have been shown to display a wide range of autoxidation rate constants. In this work, we have thoroughly studied the mechanism underlying the autoxidation process by means of state-of-the-art computer simulation methodologies, using Mb and site directed mutants as benchmark cases. Our results explain the observed autoxidation rate tendencies in different variants of Mb, L29F &lt; wt &lt; L29A = H64Q &lt; H64F &lt; H64A, and shed light on several aspects of the reaction at the atomic level. First, water access to the distal pocket is a key event and the observed acid catalysis relies on HisE7 protonation and opening of the His gate to allow water access, rather than protonation of the oxy heme itself. Our results also suggest that the basic mechanism, i.e., superoxide displacement by hydroxide anion, is energetically more feasible. Finally, we confirmed that distal hydrogen bonds protect the oxy complex from autoxidation.","palabras_clave":"autoxidation|myoglobin|qm\/mm|molecular dynamics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18228,"idioma_id":4,"titulo":"?Green electrodes? modified with Au nanoparticles synthesized in glycerol, as electrochemical nitrite sensor","resumen":"A new environmentally friendly Au nanoparticles (Au NPs) synthesis in glycerol by using ultraviolet irradiation and without extra-added stabilizers is described. The synthesis proposed in this work may impact on the non-polluting production of noble nanoparticles with simple chemicals normally found in standard laboratories. These Au NPs were used to modify a carbon paste electrode (CPE) without having to separate them from the reaction medium. This green electrode was used as an electrochemical sensor for the nitrite detection in water. At the optimum conditions the green sensor presented a linear response in the 2.0 x 10-7- 1.5 x 10-5 M concentration range, a good detection sensitivity (0.268 A L mol-1), and a low detection limit of 2.0 x 10-7 M of nitrite. The proposed modified green CPE was used to determine nitrite in tap water samples.","palabras_clave":"green electrodes|gold nanoparticles|synthesis in glycerol|nitrite sensor"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18229,"idioma_id":4,"titulo":"Using Time Series Analysis to support the Water Resources Management in the Upper Basin of the Suquía River","resumen":"A time series analysis is a valuable tool to get information about analyzed data structures and their components, which providesa good basis for successful future predictions. This information is useful to make decisions for the best management of thisresource. The region where the province of Cordoba is located is subject to strong variations in their hydrological cycles. Thestrong population growth experienced in the recent years in the city of Cordoba and its area of influence (Area of Greater Co&#769;rdoba)with more than 1.4000.000 inhabitants has resulted in conflicts in the uses of water. During the last decades this area hasexperienced prolonged droughts and floods. The Suqu&#305;&#769;a River is the most important source of water supply to the City of Co&#769;rdobain Argentina. This study deals with the modeling and forecasting of rainfall time series in the area of upper basin of Suqu&#305;&#769;a River.The series analyzed were San Antonio, El Condor, El Cajon and Barrio El Canal Station. The time series models that were proposedfor the analysis of each record were ARMA models. The results show that the time series analysis is a tool that offers valuableinformation on the characteristics pluviographs","palabras_clave":"Time Series Analysis | series of rainfall"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18230,"idioma_id":4,"titulo":"Halfway encounters: Meeting points of colonization routes among the southern beeches Nothofagus pumilio and N. antarctica","resumen":"The Patagonian region is characterized by a complex   biogeographic history, with evidence of deep phylogeographic breaks   shared among species. Of particular interest to conservation is the   nature of colonization and settlement patterns after the last glacial   period, including the detection of secondary contact between different   lineages and\/or hybridization among related species around   phylogeographic breaks. Here we studied population demography and past   hybridization of two widespread tree species endemic to South America, Nothofagus pumilio and N. antarctica.    Using   8 nuclear microsatellites we genotyped 41 populations of both species.   Genetic variation and structure across the geographic region were   evaluated within and among species and the past demographic history of   hybridization between the two species was inferred using Approximate   Bayesian Computation (ABC).    Northern and southern   lineages were identified in each species, and Bayesian clustering   revealed their convergence at mid latitudes (42°S). Spatial genetic   structure (SGS) also indicated the existence of a genetic discontinuity   at these latitudes, which is in agreement with previous data from   maternal DNA markers. Several populations around 42?44°S presented high   levels of genetic diversity with a decrease toward southern populations.   Even though the species are clearly differentiated (G?ST&nbsp;=&nbsp;0.335),   admixed gene pools were observed in both species. Two independent runs   of ABC suggested that inter species admixture-like patterns occurred   within the timescale of the Last Glacial Maximum (around 20,000 BP). We   also provide evidences of recent and bi-directional   hybridization\/introgression between the two Nothofagus species and describe features of the population&#347; demography in the past. The settlement of a secondary contact zone in Nothofagus   species around 42?44°S coincides with the phylogeographic breaks and   hotspots of genetic diversity found in other plant and animal species in   Patagonia, highlighting its importance as reservoir of diversity. The   characterization of the population history of native species can   contribute substantially to long-term conservation and management   policies.","palabras_clave":"SECONDARY CONTACT ZONE|PHYLOGEOGRAPHY|HYBRIDIZATION|PATAGONIAN TEMPERATE FORESTS|nSSRs|ABC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18231,"idioma_id":5,"titulo":"El proceso de envejecimiento poblacional en la ciudad de Mar del Plata. La Vivienda y el Entorno Urbano en el Área Céntrica","resumen":"El envejecimiento poblacional es un fenómeno sin precedentes a nivel mundial, y se prevé su profundización en el tiempo. Por convención de las Naciones Unidas una población se considera envejecida cuando posee más del 7% de personas mayores de 60 años. Mar del Plata se presenta como un polo gerontológico ya que el 19,4 % de su población es adulta mayor.El objetivo del presente trabajo es identificar diferentes escenarios habitacionales para las personas mayores en el territorio de la ciudad, mediante el análisis de los datos INDEC-Censo 2010; relacionándolos con datos cualitativos obtenidos de diferentes trabajos de nuestro grupo de investigación.El estudio de la vivienda y el entorno urbano inmediato en la zona céntrica de la ciudad permite identificar la superposición de recursos, que puestos en red, suelen complementar el hábitat doméstico. Estos estudios servirán de base para intervenciones tendientes a mejorar el envejecimiento de las personas en zonas más desfavorables.","palabras_clave":"ENVEJECIMIENTO POBLACIONAL|POLOS GERONTOLÓGICOS|CONDICIONES HABITACIONALES|CIUDAD Y VIVIENDA|ENTORNO URBANO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18232,"idioma_id":4,"titulo":"Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs","resumen":"Bisphenol A (BPA) and diethylstilbestrol (DES) are xenoestrogens which have been associated with altered effects on reproduction. We hypothesized that neonatal xenoestrogen exposure affects the ovarian functionality in lambs. Thus, we evaluated the ovarian response to exogenous ovine Follicle Stimulating Hormone (oFSH) administered from postnatal day 30 (PND30) to PND32 in female lambs previously exposed to low doses of DES or BPA (BPA50: 50 &#956;g\/kg.day, BPA0.5: 0.5 &#956;g\/kg.day) from PND1 to PND14. We determined: a) follicular growth, b) circulating levels of E2, c) steroid receptors (ERA, ERB, AR) and atresia, d) mRNA expression levels of the ovarian bone morphogenetic protein (BMPs) system (BMP6, BMP15, BMP receptor type 1B, GDF9) and FSH receptor (FSHR). Lambs neonatally exposed to DES or BPA showed an impaired ovarian response to oFSH with a lower number of follicles &#8805;2 mm together with a lower number of atretic follicles and no increase in E2 serum levels in response to oFSH treatment. In addition, AR induction by oFSH was disrupted in granulosa and theca cells of lambs exposed to DES or BPA. An increase in GDF9 mRNA expression levels was observed in oFSH-primed lambs previously treated with DES or BPA50. In contrast, a decrease in BMPR1B was observed in BPA0.5-postnatally exposed lambs. The modifications in AR, GDF9 and BMPR1B may be associated with the altered ovarian function due to neonatal xenoestrogen exposure in response to an exogenous gonadotropin stimulus. These alterations may be the pathophysiological basis of subfertility syndrome in adulthood.&#956;.","palabras_clave":"BISPHENOL A (BPA) |DIETHYLSTILBESTROL (DES) |XENOESTROGENS|OVARIAN FUNCTIONALITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18233,"idioma_id":4,"titulo":"Partially redundant enhancers cooperatively maintain Mammalian Pomc expression above a critical functional threshold","resumen":"  Cell-specific expression of many genes is   conveyed by multiple enhancers, with each individual enhancer   controlling a particular expression domain. In contrast, multiple   enhancers drive similar expression patterns of some genes involved in   embryonic development, suggesting regulatory redundancy. Work in   Drosophila has indicated that functionally overlapping enhancers   canalize development by buffering gene expression against environmental   and genetic disturbances. However, little is known about regulatory   redundancy in vertebrates and in genes mainly expressed during   adulthood. Here we study nPE1 and nPE2, two phylogenetically conserved   mammalian enhancers that drive expression of the proopiomelanocortin   gene (Pomc) to the same set of hypothalamic neurons. The simultaneous   deletion of both enhancers abolished Pomc expression at all ages and   induced a profound metabolic dysfunction including early-onset extreme   obesity. Targeted inactivation of either nPE1 or nPE2 led to very low   levels of Pomc expression during early embryonic development indicating   that both enhancers function synergistically. In adult mice, however,   Pomc expression is controlled additively by both enhancers, with nPE1   being responsible for &#8764;80% and nPE2 for &#8764;20% of Pomc transcription.   Consequently, nPE1 knockout mice exhibit mild obesity whereas   nPE2-deficient mice maintain a normal body weight. These results suggest   that nPE2-driven Pomc expression is compensated by nPE1 at later stages   of development, essentially rescuing the earlier phenotype of nPE2   deficiency. Together, these results reveal that cooperative interactions   between the enhancers confer robustness of Pomc expression against gene   regulatory disturbances and preclude deleterious metabolic phenotypes   caused by Pomc deficiency in adulthood. Thus, our study demonstrates   that enhancer redundancy can be used by genes that control adult   physiology in mammals and underlines the potential significance of   regulatory sequence mutations in common diseases. ","palabras_clave":"HYPOTHALAMUS|GENE REGULATION|PROOPIOMELANOCORTIN|TRANSCRIPTION FACTOR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18234,"idioma_id":4,"titulo":"Characterization of Fatigue Life of Ultrafine Grained NiTi Superelastic Wires Under Uniaxial Loading","resumen":"The role of the stress induced martensitic transformation on the fatigue life of Ni-rich ultrafine grained NiTi superelastic wires has been investigated. Two types of experiments have been considered to elucidate the question. In the first class, the stress range was kept in between the forward and reverse plateaus levels, thus avoiding evident martensitic stress induced transformation. Strain controlled experiments were performed in wires in fully austenite, fully stress induced martensite and austenite?martensite coexistence zone with nearly half of the wire length transformed to martensite. In the second type of experiments, pseudoelastic cycling was performed. In this case the stress induced austenite to martensite transformation is involved. The obtained results  indicate a definite deleterious effect of the stress induced transformation on the fatigue life. Additional important aspects related  with fatigue life of NiTi wires like fretting fatigue effects in the grip \/specimen contact region and the relative importance of the  crack initiation and crack propagation stages on the total fatigue life are also presented.","palabras_clave":"NITI SHAPE MEMORY ALLOYS|FATIGUE|PSEUDOELASTICITY|MEAN STRESS EFFECTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18235,"idioma_id":4,"titulo":"Superelastic Behavior of NiTi: Effects of the stress level applied during the heat treatment of cold worked wires","resumen":"The effects of the stress level applied during the final straight annealing treatment of cold worked Ni rich NiTi wires (50.8 at% Ni, diameter 50 &#956;m) on the resulting superelastic properties is addressed. Explored parameters were 400 and 500 &#730;C for heat treatment temperature, 6, 10 and 30 min for time duration and annealing stresses ranging from 10 to 800 MPa. Heat treated wires were subjected to complete superelastic cycles. Superelastic behavior was characterized by forward \/ reverse transformation stresses, dissipated energy and residual strain. No significant effect of the stress level on the pseudoelastic stability upon cycling was detected but a remarkable inclination of upper and lower transformation plateaus was obtained for the highest annealing stresses. These results are of particular significance for applications were a more gradual increase of the fraction of transformed material with stress is required, e.g. in proportional actuators.","palabras_clave":"cold worked wires|stress assisted annealing|superelastic behavior"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18236,"idioma_id":4,"titulo":"Variability in almond oil chemical traits from traditional cultivars and native genetic resources  from Argentina","resumen":"Almond (Prunus dulcis (Miller) D.A. Webb) genetic resources (Marcona, Guara, Non Pareil, IXL, AI,Martinelli C, Emilito INTA, Cáceres Clara Chica, Javier INTA) were studied during two consecutive cropyears in order to evaluate variations in kernel oil yield and composition, and oil oxidative parameters.Total oil, oleic acid, a-tocopherol and squalene contents were found to range between 48.0% and57.5%, 65% and 77.5%, 370 and 675 lg\/g oil, and 37.9 and 114.2 lg\/g oil, respectively. The genotypewas the main variability source for all these chemical traits. The a-tocopherol content seems to be themost important contributor to both the radical scavenging capacity and the oxidative stability of almondoils analysed. Results obtained from the local genotypes namely Martinelli C, Emilito INTA and JavierINTA may be of interest for almond breeding focused to improve kernel oil yield and composition.","palabras_clave":"Almond|Genetic resources|Oil content and composition|Oxidative stability|Phytochemicals"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18237,"idioma_id":4,"titulo":"Sowing pyrenes under aseptic conditions enhances seed germination of Ilex brasiliensis, I. pseudoboxus, and I. theezans (Aquifoliaceae).","resumen":"The seeds of Ilex species are individually enclosed by a woody endocarp, forming a dispersal unit termed pyrene, and have undeveloped embryos when fruits reach maturity. As a consequence, the seed germination rate is low even after several months under the proper conditions. In the present study, we present reliable and reproducible techniques that enhance seed germination of Ilex brasiliensis, I. pseudoboxus, and I. theezans by aseptically sowing whole pyrenes. The highest germination percentages (53-92%) were reached by in vitro culturing whole pyrenes on solidified (agar 0.65%) quarter-strength Murashige and Skoog medium with 3% sucrose and 0.1 mg l-1 zeatin, and incubating in a growth room at 27±2ºC with a 14 hours light photoperiod. Thus, the in vitro culture of whole pyrenes constitutes an easy and efficient technique to obtain a quick germination of these Ilex species and may be an alternative to embryo rescue. Rapid progress in the application of this method to breeding and preservation programs of Ilex species is expected.","palabras_clave":"SEED DORMANCY|EMBRYO RESCUE|IN VITRO CULTURE|HOLLY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18238,"idioma_id":4,"titulo":"Projection of Soil Organic Carbon Reserves in the Argentine Rolling Pampa Under Different Agronomic Scenarios. Relationship of these Reserves with Some Soil Properties","resumen":"The soil organic carbon (SOC) of the Argiudolls of the Argentine Rolling Pampa evolves rapidly. Currently,the soils richest in SOC are cultivated with intensified crop sequences (e.g. maize-double cropped wheat\/soybean,  MWS) under no tillage (NT) and the poorest ones with soybean monoculture (S) under NT. There are great uncertainties about the future projections of SOC reserves and soil fertility associated with changes in land use and management.The aim of this study was to predict soil fertility in 2032, by: a) validating the simple AMG model in long-term experiments  of the Rolling Pampa, b) correlating the SOC and active carbon pools (SOCm and Ca, respectively) modeled for 2008 with some soil properties, and c) simulating the evolution of SOC reserves under different agronomic scenarios,using the AMG model, starting from rich and poor SOC soils of the Rolling Pampa. The AMG model was able to provide satisfactory simulation of the SOC reserves (R2 = 0.87) and showed good quality of fit between Ca and particulate organic carbon (POC) and SOCm and structural stability index (SSI), indicating that the AMG model could project  SOC reserves and soil fertility. In rich SOC soils, the maintenance or increase in mean crop yields (MWS NT and MWS with high yields under NT, MWS opt., respectively) caused no changes, whereas the conversion to S under NT reduced the SOC reserves by 12%. Maize residue removal caused 4.5% SOC loss in MWS NT and no changes in MWS opt. In poor SOC soils, the continuity of S under NT and the conversion to MWS NT produced no changes; the passage to continuous or periodic shallow tillage caused 6% SOC loss; and the conversion to Miscanthus x giganteus produced an increase of 9% in SOC.","palabras_clave":"CARBON|SOIL|MODELLING|SCENARIOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18239,"idioma_id":4,"titulo":"Egg loss in females of two lithodid species following different return-to-the-water protocols","resumen":"Coastal waters of the southern tip of South America have sustained a mixed king crab fishery since the 1930s, with two target species: the southern king crab Lithodes santolla and the stone crab Paralomis granulosa. The fisheries are managed with the so-called 3S rule (Sex, Season, and Size) and females mustbe returned to the water. In king crabs, fecundity can be reduced by several mechanisms, but those related to fishing activities are only partially known. In this article, we tested experimentally whether egg loss is caused by the return of L. santolla and P. granulosa ovigerous females to the water. To do so, we performed experiments for each species with a 3 × 2 different return-to-the-water conditions: free fall, ramp, or a no-fall (control), with or without previous aerial exposure of females. Our experiments demonstrate that free fall impacts, similar to the normal practice in the fishery of the Beagle Channel,result in egg loss in both the species. Female L. santolla lost more eggs if females were exposed to air prior to the dropping. Also, eggs with more developed embryos were likely to be lost as a result of tumbling. In both the species,the use of a ramp for the returning of crabs to water caused an egg loss similar to those of the experimental controls. In P. granulosa fecundity from three areas with different fishing effort suggest that the return of females to the water may be a negative effect that could be detected at a populationlevel. To our knowledge, this is the first study that demonstrates the egg loss of female crabs returned to the water in a fishery.","palabras_clave":"Bycatch|Discard|Artisanal Fisheries|Fecundity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18240,"idioma_id":5,"titulo":"Los efectos de la política represiva de la dictadura militar sobre la acción obrera un análisis de los conflictos en Mercedes Benz entre 1973 y 1983","resumen":"LOS EFECTOS DE LA POLÍTICA REPRESIVA DE LA DICTADURA MILITAR SOBRE  LA ACCIÓN OBRERA: UN ANÁLISIS DE LOS CONFLICTOS EN MERCEDES BENZ  ENTRE 1973 Y 1983  El artículo analiza la acción gremial desarrollada por los trabajadores de la empresa automotriz  Mercedes Benz entre los años 1973 y 1983. A partir de la reconstrucción de los conflictos  encabezados por los trabajadores y de las acciones de represión que sufrieron por parte de la empresa  y del Estado, el trabajo se adentra en el debate sobre el carácter de la acción obrera bajo la dictadura  (continuidad o ruptura; ofensivo o defensivo). Para hacer la reconstrucción de las acciones obreras y  represivas se utilizaron diversas fuentes: entrevistas a ex-trabajadores de la empresa, los registros de  la Dirección de Inteligencia de la Policía de la provincia de Buenos Aires (DIPBA), artículos de  prensa tanto de las fuerzas políticas que actuaban en la fábrica como de la prensa de circulación  nacional, e información surgida de los procesos judiciales realizados por los delitos de lesa  humanidad cometidos durante la dictadura militar.  Palabras claves: Represión ? Dictadura militar ? Conflictos obreros ? Industria automotriz","palabras_clave":"Represión|Dictadura militar|Conflictos obreros|Industria automotriz"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18241,"idioma_id":4,"titulo":"Parental age influences developmental stability of the progeny in Drosophila","resumen":"The stochastic nature of biochemical processes is a source of variability that influences developmental stability. Developmental instability (DI) is often estimated through fluctuating asymmetry (FA), a parameter that deals with within-individual variation in bilateral structures. A relevant goal is to shed light on how environment, physiology and genotype relate to DI, thus providing a more comprehensive view of organismal development. Using Drosophila melanogaster isogenic lines, we investigated the effect of parental age, parental diet and offspring heterozygosity on DI. In this work, we have uncovered a clear relationship between parental age and offspring asymmetry. We show that asymmetry of the progeny increases concomitantly with parental age. Moreover, we demonstrate that enriching the diet of parents mitigates the effect of age on offspring symmetry. We show as well that increasing the heterozygosity of the progeny eliminates the effect of parental age on offspring symmetry. Taken together, our results suggest that diet, genotype and age of the parents interact to determine offspring DI in wild populations. These findings provide us with an avenue to understand the mechanisms underlying DI.","palabras_clave":"Developmental instability|Fluctuating asymmetry|Parental age|Diet|Inbreeding|Drosophila"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18242,"idioma_id":4,"titulo":"Oral Multicomponent DNA Vaccine Delivered by Attenuated Salmonella Elicited Immunoprotection against American Trypanosomiasis","resumen":"We have reported that attenuated Salmonella (S) carrying plasmids encoding the cysteine protease cruzipain(Cz) protects against Trypanosoma cruzi infection. Here, we determined whether immunoprotection couldbe improved by the oral coadministration of 3 Salmonella carrying the plasmids that encode the antigens Cz,Tc52, and Tc24. SCz+STc52+STc24?immunized mice presented an increased antibody response against eachantigen compared with those in the single antigen?immunized groups, as well as higher trypomastigotes antibody-mediatedlyses and cell invasion inhibition compared with controls. SCz+STc52+STc24?immunized and?challenged mice rendered lower parasitemia. Weight loss after infection was detected in all mice except those inthe SCz+STc52+STc24 group. Moreover, cardiomyopathy-associated enzyme activity was significantly lower inSCz+STc24+STc52?immunized mice compared with controls. Few or no abnormalities were found in muscletissues of SCz+STc24+STc52?immunized mice, whereas controls presented with inflammatory foci, necrosis,and amastigote nests. We conclude that a multicomponent approach that targets several invasion and metabolicmechanisms improves protection compared with single-component vaccines.","palabras_clave":"Chagas disease|; American trypanosomiasis|; Trypanosoma cruzi| multicomponent vaccine"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18243,"idioma_id":4,"titulo":"Computer Simulation of the Blood Flow in a Planar Configuration for a Pulsatile Ventricular Assist Device","resumen":"Patients that suffer congestive cardiac insufficiency need to be assisted with assist devices (VAD) as a temporal solution when the cardiac transplantation is not possible. For that reason it is of great interest to know the performance of such devices, especially the potential blood damage that they can produce. In this work, a computational twodimensional simulation of a novel pulsatile VAD is performed. This new design of VAD has a double acting piston driven electromagnetically at 2.1 Hz. In addition, the VAD has four active valves. The flow velocities, the pressure and the shear stress developed in the blood are analyzed in the chambers and inflow and outflow conduits. The results suggest that the developed flow would not be dangerous for the blood.","palabras_clave":"Blood pump|Finite element|Ventricle assist device"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18245,"idioma_id":5,"titulo":"Abejas asociadas a cultivos de Berenjena (Solanum melongena L, Solanaceae) en invernadero del Cinturón Hortícola de La Plata, Buenos Aires, Argentina.","resumen":"El cultivo de berenjena tiene en muchos países gran importancia económica, por este motivo actualmente se encuentra en amplia expansión a nivel mundial. En este trabajo se estudiaron las abejas asociadas a este cultivo producido en invernadero en la zona hortícola de La Plata, Buenos Aires, Argentina. Se reconocieron un total de 21 especies de abejas asociadas al cultivo; siendo la familia Halictidae las más representativa con 15 especies seguida de Apidae con cuatro. El pico de las visitas florales se registró en el horario matinal entre las 08:30hs y 11:30hs, coincidiendo con el comienzo de la antesis y dehiscencia de las anteras. Concluimos que las especies Bombus atratus y Xylocopa augusti pueden considerarse como las especies con mayor potencial para la polinización dirigida de este cultivo en invernadero.","palabras_clave":"VISITAS FLORALES|POLINIZACIÓN|ANTHOPHILA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18246,"idioma_id":4,"titulo":"Genetic versus environmental contributions to variation in seedling resprouting in Nothofagus obliqua","resumen":"Resprouting is an almost universal functional trait in temperate angiosperms and confers persistence at an individual level after the loss of above-ground biomass. The importance of genetic versus environmental sources of intraspecific  variation in resprouting traits is largely unknown. We conducted two genetic field trials, 400 m apart in altitude, in order to sequentially assess seedling resprouting in four environmentally contrasting Argentinean populations of  Nothofagus obliqua Mirb. (Oerst). We also performed one nursery test to determine whether populations differed in early root\/shoot biomass partition, a key trade-off affecting resprouting. Initial resprouting vigour and final survival were higher in our warmer test site, located 300 m below the core  range of the species. The main contrasts between populations  were found for pre-clipping seedling size and resprouting profusion,  the latter trait showing a clear trade-off with resprouting vigour. Site×population interactions were due mainly to the behaviour of the highest altitude population, suggesting its divergent adaptive trajectory and higher plasticity for resprouting traits. Within populations, trait heritability  was low, in general. Episodic frost, which may limit resprouting vigour and final success, had a lower incidence in the altitudinal and xeric limit populations. Overall, our work revealed genetic variation between populations of N. obliqua in traits that determine the success of seedling resprouting,  probably associated with divergent selection. Low trait heritability  suggests limited in situ micro-evolutionary capacities  for resprouting traits under ongoing climate warming; phenotypic  plasticity may play an important role in population persistence  at the low positions of the elevation gradients N. obliqua currently inhabits.","palabras_clave":"MEDITERRANEAN CLIMATE|SOUTHERN ANSIOSPERM|FITNESS TRAITS|POPULATION DIFFERENTIATION|HERITABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18247,"idioma_id":4,"titulo":"Phononic heat transfer through a one dimensional system subject to two sources of nonequilibrium","resumen":"We analyze the energy transport in a one dimensional chain composed by two Frenkel-Kontorova (FK) segments connected together by a time modulated coupling. The ends are inmersed in two thermal reservoirs with oscillating temperatures. We observe a single and multiresonant heat transport depending on the regimes considered, with a crossover between a mechanical resonance and a thermodynamical resonance. The dynamical tuning between these two regimes requires the synergetic presence of both time dependent sources of nonquilibrium. In the single resonant regime we analyze a ?red shifted? resonant frequency that is dependent on the size of the system.","palabras_clave":"HEAT TRANSPORT|PHONONICS|THERMAL RECTIFICATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18248,"idioma_id":4,"titulo":"Survival of Pseudomonas aeruginosa exposed to sunlight resembles the phenom of persistence","resumen":"During exposure of Pseudomonas aeruginosa stationary phase   cells to natural solar radiation, a reduction in the rate of loss of   bacterial viability was observed when survival fractions were lower than   1\/10,000. This reduction was independent of the growth medium used and   of the initial bacterial concentration, and was also observed when   irradiation was performed with artificial UVA radiation (365&nbsp;nm, 47&nbsp;W&nbsp;m&#8722;2).   These results indicate the presence of a small bacterial subpopulation   with increased tolerance to radiation. Such a tolerance is   non-heritable, since survival curves comparable to those of the parental   strain were obtained from survivors to long-term exposure to radiation.   The radiation response described here resembles the phenomenon called   persistence, which consists of the presence of a small subpopulation of   slow-growing cells which are able to survive antibiotic treatment within   a susceptible bacterial population. The condition of persister cells is   acquired via a reversible switch and involves active defense systems   towards oxidative stress. Persistence is probably responsible for   biphasic responses of bacteria to several stress conditions, one of   which may be exposure to sunlight. The models currently used to analyze   the lethal action of sunlight overestimate the effect of high-dose   irradiation. These models could be improved by including the potential   formation of persister cells.","palabras_clave":"Pseudomonas|sunlight|UVA|Survival"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18249,"idioma_id":5,"titulo":"Docentes y alumnos, sus miradas sobre los conflictos. Algunas ideas para promover cambios en la escuela secundaria. Parte II","resumen":"Las investigaciones de las que daremos cuenta surgen en el marco de la carrera de Resolución de conflictos y Mediación de UNTREF, con las inquietudes y cuestionamientos que comparten tanto docentes como alumnos acerca de la viabilidad de la mediación en el ámbito escolar. Estas han sido: Perspectivas de docentes y alumnos para la mediación escolar? (2010-2011) y Perspectivas de docentes y alumnos para la mediación escolar: desarrollo de programas? (2012\/2013).Partiendo del análisis de los programas vigentes de mediación escolar, observamos que éstos no incluyen las representaciones sociales de los adultos de la escuela respecto de los conflictos, su resolución, la violencia, ni acerca de sus alumnos, la adolescencia y juventud de hoy.&nbsp;","palabras_clave":"Representaciones|Docentes|Conflictos|Mediación"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18250,"idioma_id":4,"titulo":"Direct versus indirect facilitation (herbivore mediated) among woody plants in a semiarid Chaco forest: A spatial association approach","resumen":"In arid environments, direct facilitation (microhabitat amelioration) and indirect facilitation (?associational resistance? via protection from herbivory) among plants of different species may act simultaneously. Little is known about their relative effects. One way to disentangle the effects is by evaluating spatial associations. We examined the relative importance of these two mechanisms of facilitation in the semiarid Chaco vegetation of north-central Argentina, through an eight-way observational study in which we quantified the degree of spatial association between saplings of each of two key tree species, Schinopsis lorentzii (Anacardiaceae) and Aspidosperma quebracho-blanco (Apocynaceae), with shrub neighbours either possessing spines or without spines and in both an ungrazed site and a site with a long history of cattle grazing. We analysed data across 400 subparcels at each site with SADIE (Spatial Analysis by Distance Indices). Saplings of both tree species showed positive spatial associations with spiny shrubs in the grazed site but not in the ungrazed site, and never with non-spiny shrubs. This result suggests that spiny shrubs may indeed provide associational resistance (AR) for saplings of key tree species in grazed habitats in these dry subtropical forests, that is, that indirect facilitation may predominate over direct facilitation. If confirmed by experimental studies, this result can have implications for the silvopastoral management of rapidly expanding ranches in the semiarid Chaco, where current practice includes the near elimination of native shrubs.","palabras_clave":"ASSOCIATIONAL RESISTANCE|CHACO|FACILITATION|GRAZING|SPINY SHRUBS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18251,"idioma_id":4,"titulo":"Disentangling the effects of shrubs and herbivores on tree regeneration in a dry Chaco forest (Argentina)","resumen":"Abstract Successful persistence of dry forests depends on tree regeneration, which depends on a balance of complex biotic interactions. In particular, the relative importance and interactive effects of shrubs and herbivores on tree regeneration are unclear. In a manipulative study, we investigated if thornless shrubs have a direct net effect, an indirect positive effect mediated by livestock, and\/or an indirect negative effect mediated by small vertebrates on tree regeneration of two key species of Chaco forest (Argentina). In a spatial association study, we also explored the existence of net positive interactions from thorny and thornless shrubs. The number of Schinopsis lorentzii seedlings was highest under artificial shade with native herbivores and livestock excluded. Even excluding livestock, no seedlings were found with natural conditions (native herbivores present with natural shade or direct sunlight) at the end of the experiment. Surprisingly, seedling recruitment was not enhanced under thornless shrubs, because there was a complementary positive effect of shade and interference. Moreover, thornless shrubs had neither positive nor negative effects on regeneration of S. lorentzii. Regeneration of Aspidosperma quebracho-blanco was minimal in all treatments. In agreement with the experiment, spatial distributions of saplings of both tree species were independent of thornless shrubs, but positively associated with thorny shrubs. Our results suggest that in general thornless shrubs may have a negligible effect and thorny shrubs a net positive effect on tree regeneration in dry forests. These findings provide a conceptual framework for testing the impact of biotic interactions on seedling recruitment in other dry forests.","palabras_clave":"LIVESTOCK|FACILITATION|HERBIVORY|NURSE PLANTS|SPATIAL ASSOCIATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18252,"idioma_id":4,"titulo":"A NATURAL LANGUAGE REQUIREMENTS ENGINEERING APPROACH FOR MDA","resumen":"A software system for any information system can be developed following a model driven paradigm, in particular MDA (Model Driven Architecture). In this way, models that represent the organizational work are used to produce models that represent the information system. Current software development methods are starting to provide guidelines for the construction of conceptual models, taking as input requirements models. In MDA the CIM (Computation Independent Model) can be used to define the business process model. Though a complete automatic construction of the CIM is not possible, we have proposed in other papers the integration of some natural language requirements models and we have defined a strategy to derive a CIM from these models. In this paper, we present an improved version of our ATL transformation that implements a strategy to obtain a UML class diagram representing a preliminary CIM from requirements models allowing traceability between the source and the target models.","palabras_clave":"ATL transformatios|MDA|Natural Language Requirements Models|Traceability"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18253,"idioma_id":4,"titulo":"Effect of heat input on the Fe-based nanostructured weld overlay","resumen":"In the last few years, several welding consumables have been developed that deposit hard iron-based nanostructured alloycoverings with high resistance to abrasive wear. The erosive and abrasive wear resistances are mainly controlled by thechemical composition and the microstructure. In turn, the microstructure of the deposited metal can show variations with theused welding procedure, particularly in relation to the heat input. The operating parameters that define the heat input(voltage, current and welding speed) affect aspects such as bead geometry (wide, penetration and reinforcement) anddilution with the base material. The purpose of this article is to study the effect of heat input on the geometric characteristicsof the bead, the dilution and the microstructural evolution of a nanostructured iron-based alloy deposited by FCAW. Severalsamples with heat input between 0.5 and 3.5 kJ\/mm were welded. A dimensional study was carried out for each weldedcoupon, the chemical composition was analysed and the microstructure was characterized using optical and electronicscanning microscopy and X-ray diffraction. Microhardness, crystallite size and degree of dilution were also measured. Greatinfluence in these conditions in the process was observed about the geometry of the bead. The dilution varied between 30%and 40%; microhardness of the deposit was found between 800 and 870 HV1, and the size of the crystallite varies between105 and 130 nm, depending on process variables used. The highest hardnesses and the lowest crystallite sizes were obtainedwith the lowest heat input, associated with a lower dilution.","palabras_clave":"hardfacing |nanomaterials|heat input|hardness"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18254,"idioma_id":5,"titulo":"SOLUCIÓN ANALÍTICA-NUMÉRICA PARA LA TRAYECTORIA DE RAYOS SÍSMICOS EN MEDIOS CON HETEROGENEIDAD VERTICAL","resumen":"La propagación de ondas sísmicas generadas en emisores y detectadas en receptores en medios heterogéneos yanisotrópicos sigue una trayectoria curva determinada por el principio de tiempo mínimo de Fermat. La aplicacióndel cálculo de variaciones conduce a una ecuación diferencial ordinaria. Debido a la compactación del terrenonormalmente la velocidad aumenta con la profundidad, estando esta variación sujeta a leyes experimentales paracada suelo, lo que lleva a resolución numérica en los casos generales. En este trabajo se estudia el ajuste de datosexperimentales de velocidad por una función exponencial; la integración analítica de la ecuación diferencial y ladeterminación numérica de las constantes de integración. Los datos experimentales suelen determinarse por algúnmétodo geofísico tal como up-hole o down-hole. Su aplicación principal se centra en el diseño de modelos numéricosde trayectorias curvas y por ende luego tiempos de primeros arribos a través de algoritmos de inversión tomográficospara detección y modelado de anomalías en los primeros 12m. de profundidad.","palabras_clave":"Anisotropía|Rayos curvos|principio de fermat|heterogeneidad vertical"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18255,"idioma_id":4,"titulo":"Osteology and phylogenetic relationships of Tyrannotitan chubutensis Novas, de Valais, Vickers-Rich and Rich 2005 (Theropoda: Carcharodontosauridae) from the Lower Cretaceous of Patagonia, Argentina","resumen":"The theropod clade Carcharodontosauridae is a broadly distributed group of large allosauroid theropods. The carcharodontosaurids recorded in the Albian-Cenomanian of Gondwana are the youngest and most derived members of this clade. Tyrannotitan chubutensis, from the Cerro Castaño Member of Cerro Barcino Formation (Albian; Chubut Group), Central Patagonia, Argentina is of prime interest among Gondwanan carcharodontosaurids as it represents the oldest record of the group. Here we offer a detailed osteological comparative description of the holotype and paratype of Tyrannotitan chubutensis together with a new diagnosis of the species. The new information results in a better understanding of this taxon and Carcharodontosauridae. Furthermore, a comparative study of the anatomy of the pectoral girdle of Giganotosaurus is reinterpreted as very similar to that of Tyrannotitan and Mapusaurus. We also present a phylogenetic analysis of Carcharodontosauridae that recovers Tyrannotitan as a derived carcharodontosaurid, being the sister group of the clade formed by Giganotosaurus and Mapusaurus, all nested in the clade Giganotosaurini.","palabras_clave":"Theropoda|Cretaceous|Carcharodontosauridae|Phylogeny"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18256,"idioma_id":4,"titulo":"Mineral reactions associated with hydrocarbon paleo-migration in the Huincul High, Neuquén basin, Argentina","resumen":"Bleaching of red beds by the migration of reducing pore fluids is a widespreadphenomenon, with most previous work on the topic focused on detailed studies in the southwestern United States, and to a lesser extent Germany. Herein, we report onwidespread bleaching of Cretaceous red beds in the Neuquén Basin and the relationship ofthis bleaching to hydrocarbon migration. In the Cerro Granito area of the Huincul High,Neuquén Basin, the basal deposits of the Neuquén Group (Candeleros and HuinculFormations) are bleached. This alteration was apparently controlled by fluid and host-rockcomposition as well as by the intensity and span of the fluid-rock interaction. Red, finegrained sandstones and mudstones of the Candeleros Formation were deposited in fluvialand swamp environments and contain authigenic hematite, Na-rich corrensite, micro- andmesoquartz, calcite, and analcite. Coarse-grained sandstones and mudstones of the HuinculFormation, which overlie the Candeleros Formation, were deposited in a braided fluvialsystem, under more humid and acidic conditions than the Candeleros Formation.Sandstones are similar in composition and texture to the Candeleros sandstones, except they contain less basic volcanic detritus and lack corrensite. Bleached facies in bothformations contain bitumen and clusters of calcite + bitumen concretions, and partiallydissolved detrital clasts and most cements, including early Fe-oxides, which resulted in anincrease in secondary porosity and bleaching of the red beds. Alteration of the CandelerosFormation is confined to medium- to coarse-grained sandstone in which corrensite ispartially dissolved and its interlayer charge is satisfied by Ca instead of Na, as in corrensitefrom the red sandstones. Extensive dissolution occurred in the Huincul Formation, whichfavored the precipitation of new authigenic minerals such as smectite, mixed-layer chloritesmectite, and pyrite. Bleaching and associated alteration most likely resulted from interaction of hydrocarbons with the red beds. Hydrocarbon paleomigration in the Cerro Granito area occurred in higher-permeability portions of the Candeleros and HuinculFormations. The seal provided by the Lisandro Formation was breached during upliftdriven by Tertiary tectonism, resulting in the exhumation of the Huincul and CandelerosFormations. This study highlights the importance of a variety of alterations, includingcomplex clay mineral paragenesis, contemporaneous with bleaching of the red beds. Such alterations can potentially be used to provide evidence for the passage of chemicallyreducing fluids associated with hydrocarbons in other regions, including cases where theoriginal red color has been completely removed.","palabras_clave":"CRETACEOUS|RED BEDS|BLEACHING|CLAY MINERALS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18257,"idioma_id":4,"titulo":"Galacto-oligosaccharides formation during manufacture of different varieties of yogurt. Stability through storage","resumen":"Galacto-oligosaccharides (GOS) have interest in the food industry due to their recognized functional properties. In this work, we studied the effect of a commercial beta-galactosidase enzyme from Kluyveromyces lactis (YNL-2, GODO) and Lactobacillus acidophilus La-5, on GOS formation during the manufacture and storage of drinkable and stirred yogurts. In a preliminary step, GOS synthesis and lactose hydrolysis by beta-galactosidase was evaluated at different initial lactose concentrations and doses of enzyme. The GOS formation was favored with increasing of lactose concentration and enzyme doses, while the hydrolysis dominated at lower level of lactose. In turn, the presence of GOS was already evident at 45 min of fermentation in yogurts with addition of beta-galactosidase. Mean concentrations were 0.36 and 0.62 g\/100 g for fresh drinkable and stirred yogurts, respectively. No changes in the GOS levels were observed through storage, indicating that they were stable in the products. The probiotic bacteria added were not able to produce GOS. The diminution of lactose was significant in yogurts with beta-galactosidase; contents of residual lactose were around 1.3 g\/100 mL. We obtained different varieties of reduced-lactose yogurts enriched in galacto-oligosaccharides. The presence of probiotic and prebiotic would increase the functional properties of yogurts.","palabras_clave":"GALACTO-OLIGOSACCHARIDES|BETA-GALACTOSIDASE|LACTOBACILLUS ACIDOPHILUS|YOGURT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18258,"idioma_id":4,"titulo":"Thermodynamic study of water sorption and water barrier properties of nanocomposite films based on brea gum","resumen":"Water transport in edible &#64257;lms based on hydrophilic polymers is a complex phenomenon due to the strong interactions of sorbed water molecules with the polymeric structure. The effect of montmorillonite (Mt) nanoparticle incorporation into brea gum (BG) based &#64257;lms was studied through thermodynamic and phenomenological analyses. Moisture adsorption isotherms at three different temperatures of BG based &#64257;lms and BG\/Mt nanocomposite &#64257;lms were obtained. Thermodynamic parameters showed an exothermic process that results less favourable when Mt is incorporated into the BG matrix, reducing the water uptake. Entropy change and netisosteric heat of adsorption showed a peak at monolayer water content, which is greater in composite &#64257;lms, indicating a more stable and ordered structure when Mt was added. Gibb´s energy was indicative of process spontaneity and of the lower af&#64257;nity to water composite &#64257;lms. Water vapour permeability depends on the tortuosity of the pathway formed by Mt nanoparticles and solubility of water molecules into the BG &#64257;lm matrix. Mt incorporation reduces the hydrophilic character of BG based &#64257;lms and thus their water vapour permeability.","palabras_clave":"BREA GUM\/ MMT FILM|SORPTION ISOTHERMS|PERMEABILITY|THERMODYNAMIC PARTAMETERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18259,"idioma_id":5,"titulo":"ANÁLISIS DEL EFECTO DE BACTERIAS SOLUBILIZADORAS NATIVAS SOBRE LA MOVILIZACIÓN DE FÓSFORO EN SUELOS ROJOS ARGENTINOS Y SU ABSORCIÓN EN NARANJO","resumen":"Una de las principales limitantes de la producción en los suelos lateríticos es la baja disponibilidad de fósforo (P). Las bacteriasdel suelo conocidas como bacterias solubilizadoras de fosfato (PSB) tienen la capacidad de solubilizar formas insolubles deP inorgánico principalmente mediante la producción de ácidos orgánicos y la quelación de óxidos de calcio, hierro o aluminio.La inoculación con PSB seleccionadas para aumentar la población nativa puede movilizar P a partir de fuentes poco disponiblesy por lo tanto mejorar la nutrición de las plantas. El objetivo de este estudio fue evaluar el efecto de la inoculación sobrelas distintas formas de P en suelo, así como sobre la absorción de P por las plantas de naranjo (Citrus sinensis) variedad Newhall.La inoculación evidenció un efecto positivo sobre la nutrición vegetal al incrementar el contenido foliar de P. Este incrementofue más notable en los ensayos inoculados y fertilizados. La inoculación con las cepas Enterobacter aerogenes R4M-A yBurkholderia caledonica R4M-O benefició el incremento de las distintas formas de P disponibles del suelo, y también la absorciónde P por las plantas de naranjo (C. sinensis) variedad Newhall.","palabras_clave":"PGPR|bacterias PSB|fósforo edáfico|nutrición vegetal"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18260,"idioma_id":4,"titulo":"First generation newkome-type dendrimer as solubility enhancer of antitumor benzimidazole carbamate","resumen":"A first generation dendrimer was evaluated as solubility enhancer of the antitumor compound methyl (5-[propylthio]-1H-benzimidazol-2-yl) carbamate. The dendrimer possess carboxylic acid as terminal groups, which provide high water solubility and a low cytotoxic character. The drug-dendrimer association significantly increases active compound solubility in water, avoiding aggregation. The formulation is stable several weeks in a wide temperature range. The formation of Langmuir monolayers in air-water interface of dendrimer-active compound blends evinces the viability of the complex to generate films for surface-mediated drug delivery systems.","palabras_clave":"DENDRIMER|SOLUBILITY|ANTITUMOR|BIOMATERIALS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18261,"idioma_id":4,"titulo":"Evapotranspiration of subtropical forests and tree plantations: A comparative analysis at different temporal and spatial scales","resumen":"The area of tree plantations in the humid subtropical region of Northern Argentina has recently increased  five folds. However, the impact of this land use change on evapotranspiration (ET), one of the main  components of the hydrologic cycle, has not been evaluated. We studied the ET at tree and ecosystem  levels for native forests and three tree plantations (Pinus taeda, Araucaria angustifolia and Eucalyptus  grandis). Water consumption of individual trees was estimated using sap flow measurements. Ecosystem  ET was characterized using both remote sensing derived data products (ETMODIS) for 2000?2011 and  scaling up from tree sap flow measurements to stand level. Canopy conductance (gc) was estimated using  both sap flow measurements and ETMODIS data. At individual level, transpiration was positively related to  the size of the tree, and the relationship was well described by an exponential function when all species  (both native and cultivated trees) were included in the analysis. The average annual leaf area index was  similar between native forest and tree plantations. The ET estimates obtained from scaling up sap flow  measurements and from ETMODIS were relatively similar in most cases and differed by 4?34%, depending  on the ecosystem. The tree plantations, regardless of density or age, did not show higher ETMODIS than  native forests. The ET ranged from 1161 to 1389 mm per year across native forests and tree plantations  according to remote sensing, representing 58?69% of the annual precipitation. Furthermore, the good  agreement between ET estimates, with the exception of E. grandis, obtained using sap flow and remote  sensing provide a good basis for predicting the effects of land conversion from native forest to most nonnative  tree plantations on regional ET. Monthly ETMODIS increased with increasing monthly air saturation  deficit (ASD) up to 0.8 kPa, value at which ETMODIS did not increase further probably due to stomatal  control and low values of gc. Different negative exponential relationships between gc and ASD were  obtained when gc was calculated by scaling up daily tree sap flow to ecosystem level. Canopy conductance  (estimated by remote sensing) declined in a similar negative exponential fashion with increasing ASD,  and no differences were observed across ecosystem types. The result of increasing the time step, from  daily to monthly, and the spatial scale from individual tree to stand level, had the consequence to lower,  even to eliminate differences in annual ET and gc among ecosystems in their responses to climate drivers.  This suggests that the nature of ET regulation at individual and ecosystem levels could be different, which  should be taken into account when predicting the effects of changes in land use on regional hydrology.","palabras_clave":"CANOPY CONDUCTANCE|CLIMATIC DETERMINANTS OF TRANSPIRATION|WATER CONSUMPTION|REMOTE SENSING|SAP FLOW"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18262,"idioma_id":10,"titulo":"O Campo teórico da política educacional: modelos, abordagens e objetos de estudo","resumen":"Solicitado por autorización para publicar en portugues. Versión original en: Jornal de PolíticasEducacionais. N° 14 | Julho-Dezembro de 2013 | pp. 62?75Estetrabalho, de caráter teórico, propõe-se a apresentar algumas reflexõesconceituais que estão sendo desenvolvidas no contexto do que chamamos asEpistemologias da Política Educacional, que, através do Enfoque dasEpistemologias da Política Educacional (EEPE) tem por finalidade propor umesquema de análise sobre o campo da investigação em política educacional comoum campo teórico, a partir de componentes que contribuem para a reflexão campometa-analítica do campo. Assim, propomos três argumentos a partir dos quais sepode definir o objeto de estudo da política educacional, assumindo que a suadefinição, modelo e abordagem é múltipla e multidimensional. O primeiroargumento está relacionado com a categoria de episteme de epoca; o segundo coma posição epistemológica do pesquisador e o terceiro diz respeito aoentrelaçamento dos traços históricos e o modo de nomear do campo teórico dapolítica educacional. Por fim, apresentamos algumas ideias que podem orientar aamplitude do campo, que tem o objetivo de definir o objeto de estudo dapolítica educacional como o estudo da tomada de decisão na educação.","palabras_clave":"Política|Educación|Epistemologías|EEPE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18263,"idioma_id":4,"titulo":"Involvement of hypoxia and inflammation in early pregnancy loss mediated by Shiga toxin type 2","resumen":"INTRODUCTION:     Symptomatic   or asymptomatic Shiga toxin producing Escherichia coli (STEC)   infections during early pregnancy may cause maternal or fetal damage   mediated by Shiga toxin type 2 (Stx2). The aim of this study is to   elucidate the mechanisms responsible for early pregnancy loss in rats   treated with Stx2.    METHODS:     Sprague   Dawley pregnant rats were intraperitoneally injected at day 8 of   gestation with a sublethal dose (0.5&nbsp;ng of Stx2\/g of total body weight,   250&nbsp;&#956;l) of purified Stx2. Control rats were injected with the same   volume of PBS. The expression of globotriaosylceramide (Gb3)   glycosphingolipid receptor for Stx2 was evaluated by thin-layer   chromatography (TLC). Regions of hypoxia in decidual tissue were   determined by pimonidazole immunohistochemistry and vascular endothelial   growth factor (VEGF) expression by Western blot and   immunohistochemistry. Tumor necrosis factor-alpha (TNF-&#945;) levels in   serum and decidual tissue were evaluated by ELISA. Serum progesterone   levels were determined by RIA.    RESULTS:     Decidual   tissue from both, control and Stx2-treated rats showed similar   expression of Gb3 receptor. Intrauterine growth restriction was observed   in Stx2-treated rats, associated with hypoxia and an increase of   decidual TNF-&#945; levels. Decrease of serum progesterone levels and   decidual VEGF expression were also demonstrated.    DISCUSSION:     Our   findings indicate that Stx2 reaches the uteroplacental unit, binds Gb3   and triggers damage in decidual tissue. Poor oxygen supply accompanied   with damage in the uteroplacental unit and inflammation could be   responsible for the early pregnancy loss. Decrease in the pregnancy   protective factors, serum progesterone and local VEGF, may contribute to   the pregnancy loss.","palabras_clave":"Shiga toxin|hypoxia|pregnancy|rat"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18264,"idioma_id":5,"titulo":"Subsistemas económicos, territorio y ambiente. El reciclaje en el conurbano sur de Buenos Aires","resumen":"El trabajo analiza el reciclaje de residuos como subsistema económico, haciendo centro en el caso de un depósito que acopia y comercializa residuos reciclables en el Municipio de Quilmes. Se estudia el rol que este emprendimiento ocupa en el circuito del reciclaje y las condiciones de los recicladores urbanos ligados a esta empresa como proveedores, la relación con el municipio y las articulaciones territoriales y económicas que se dan a partir del funcionamiento de lo que podemos llamar un subsistema local del reciclaje.","palabras_clave":"reciclaje|sector informal|subsistemas económicos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18265,"idioma_id":5,"titulo":"Efecto del raleo sobre las propiedades anatómicas de la madera de Pinus taeda","resumen":"El raleo tiene implicanciaseconómicas y técnicas para producción forestal y para la actividad industrial.El objetivo del estudio fue determinar la influencia de la intensidad de raleosobre las propiedades anatómicas de la madera. Se trabajó con muestras tomadasa 1,30 m de altura, de 24 árboles proveniente de un ensayo de raleo en Pinustaeda de 20 años de edad, intervenido a los 3 años, con remoción del 0%, 50%,75% y 87,5% de las plantas de la densidad inicial de plantación (1960 árboles\/ ha).Se midieron diámetro a la altura de pecho, altura total, diámetro en la base dela copa viva y altura a la base de la copa viva, longitud de traqueidas,espesor de pared celular y ángulo microfibrilar. La longitud de traqueidas fuemayor en el tratamiento con 87,5% de raleo. Los tratamientos con 0% y 50% deraleo favorecieron la obtención de mayores valores de espesor de pared ymenores valores de ángulo microfibrilar. Se concluyó que esta prácticasilvícola altera a las propiedades anatómicas de la madera de Pinus taeda y quela longitud de traqueidas está fuertemente relacionada con el tamaño del árboly con la longitud de la copa verde.","palabras_clave":"ANGULO MICROFIBRILAR|LONGITUD DE TRAQUEIDAS|ESPESOR DE PARED CELULAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18266,"idioma_id":5,"titulo":"Enseñar Ciencias Económicas: el papel de los docentes jóvenes en la UNC","resumen":"En investigaciones recientes, se ha comprobado que durante los últimos veinte años hubo un proceso de devaluación relativa de la profesión del docente-investigador en Argentina. La ponencia intenta examinar este proceso desde la perspectiva de los docentes jóvenes en las carreras de Ciencias Económicas, analizando el papel estratégico que dichos actores han llegado a cumplir en la estructura institucional y educativa. También se discute su situación en términos de sus percepciones y expectativas futuras.Algunas preguntas que se hace el estudio son: ¿cómo ha cambiado el papel y la situación de los docentes jóvenes en las últimas décadas? ¿Experimentan una mayor carga laboral que los docentes de otras generaciones? ¿Cuáles son sus incentivos y por qué deciden dedicarse a la docencia? Los hallazgos son reveladores, confirmando que los profesores jóvenes perciben a la docencia universitaria como una actividad complementaria y que realizan mayoritariamente por vocación personal. Los resultados presentan distintas connotaciones según el género y el área disciplinar.","palabras_clave":"DOCENTES JOVENES|ESTRUCTURA INSTITUCIONAL|CONDICIONES DE TRABAJO|CIENCIAS ECONOMICAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18267,"idioma_id":4,"titulo":"HEAVY METALS IN SEDIMENTS AND SOFT TISSUES OF THE ANTARCTIC CLAM LATERNULA ELLIPTICA: MORE EVIDENCE AS POSSIBLE BIOMONITOR OF COASTAL MARINE POLLUTION AT HIGH LATITUDES?","resumen":"Studies on metal contamination in 25 de Mayo Island, Antarctica, yielded controversial results. In this work, we analyzed Antarctic marine sediments and Antarctic clam (Laternula elliptica) tissues to investigate the possible  use of this mollusk as a biomonitor of metals and to identify the sources of metal pollution. Different types of paint from several buildings from Carlini Station were examined to assess their contribution to the local and  random metal pollution. Five sediment samples, 105 L. elliptica specimens (40.2?78.0 mm length) and fourtypes of paint were analyzed to quantify Cd, Cr, Cu, Fe, Mn, Pb and Zn using inductively coupled plasma-optical emission spectrometry. Metal concentrations in sediments were lower than the global averages of the earth´s crust, with the exception of Cd and Cu. These results were related to the contribution of the local fresh-water runoff. The different varieties of paint showed low levels of Cu, Mn, Fe and Zn, whereas a broad range of values were found in the case of Cr and Pb (20?15,100 &#956;g·g&#8722;1 and 153?115,500 &#956;g·g&#8722;1 respectively). The remains of the paint would be responsible for the significant increases in Cr and Pb which are randomly detected by us and by other authors. High levels of Fe and Cd, in comparison to other Antarctic areas, appear to be related to the terrigenous materials transported by the local streams. Accumulation indexes suggested that kidney tissue from L. elliptica could be an adequate material for biomonitoring pollution with Cd, Zn and probably also Pb. In general, relationships between size and metal contents reported by other authors were not verified, suggesting that this issue should be revised.","palabras_clave":"ANTARCTIC CLAM|METAL POLLUTION |POTTER COVE |MARINE SEDIMENTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18268,"idioma_id":5,"titulo":"Primer registro de infestación en un reptil por larvas de Amblyomma parvitarsum (Acari: Ixodidae) en Argentina","resumen":"El parasitismo es una de las formas de vida más comunes en el reino animal, sin embargo, no debe ser visto solamente desde el punto de vista económico o de la salud. Los parásitos son excelentes indicadores ecológicos y aportan información de la relaciones filogenéticas con sus hospedadores.El presente trabajo menciona, por primera vez para Argentina, la presencia de larvas de Amblyomma parvitarsum parasitando al lagarto Liolaemus eleodori (Iguania: Liolaemidae) en una localidad de la provincia de San Juan. La información biológica que se dispone de L. eleodori es escasa, reduciéndose sólo a aspectos termorregulatorios.","palabras_clave":"Liolaemus|Amblyomma|Acari|Infestación"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18269,"idioma_id":5,"titulo":"Ecología trófica y dimorfismo sexual del lagarto endémico Liolaemus eleodori (Iguania: Liolaemidae) del Parque Nacional San Guillermo, San Juan","resumen":"Se realizó un estudio de la composición de la dieta y su variación intersexual y estacional (diciembre 2004 y febrero 2005) en Liolaemus eleodori. Además, se determinó la amplitud del nicho trófico, la diversidad trófica y la relación depredador-presa; esta última medida se realizó entre el largo, ancho y volumen máximos de las presas y la morfología (LHC y medidas de la cabeza) de los depredadores. También se aporta información sobre el dimorfismo sexual. Para el análisis trófico se utilizaron los tractos digestivos. Cada ítem presa encontrado fue reconstruido para su identificación y se estimó su volumen, numerosidad y frecuencia de ocurrencia. Se utilizó el Índice de Importancia Relativa (IRI) para estimar la contribución de cada categoría de alimento a la dieta. Para examinar el dimorfismo sexual se midieron 14 variables morfológicas. Liolaemus eleodori mostró una tendencia a la alimentación omnívora, consume artrópodos: insectos, arañas, ácaros y ciempiés; siendo también frecuente la presencia del material vegetal. Los machos resultaron significativamente más grandes que las hembras en la longitud, el ancho y la altura máxima de la cabeza, en la longitud de fémur, la longitud de la cola y presentaron un mayor número de poros precloacales","palabras_clave":"Liolaemus|Endémico|Dieta|ecología"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18270,"idioma_id":5,"titulo":"ANÁLISIS ESTRATIGRÁFICO Y PALEONTOLÓGICO DEL CRETÁCICO SUPERIOR EN LA CUENCA DEL GOLFO SAN JORGE: NUEVA UNIDAD LITOESTRATIGRÁFICA PARA EL GRUPO CHUBUT","resumen":"Las características litológicas, estratigráficas y paleontológicas del registro másmoderno del Grupo Chubut en la Cuenca del Golfo San Jorge (Argentina), permitenproponer una nueva unidad litoestratigráfica dentro del grupo, la Formación LagoColhué Huapi (nov. nom.). Esta unidad se dispone por encima de la Formación BajoBarreal y por debajo de la Formación Laguna Palacios o de la Formación Salamanca. Labase y el techo son transicionales, con excepción del contacto con la FormaciónSalamanca que en algunos casos es erosivo. Sus afloramientos se extiendenampliamente en el ámbito de la cuenca. Su localidad tipo se encuentra ubicada en lasnacientes del río Chico y se propone un estratotipo compuesto: el holoestratotipo estáconstituido por el intervalo aflorante en las nacientes del río Chico (53 m de espesor), yel paraestratotipo es el intervalo aflorante en la margen sureste del Codo del ríoSenguerr (160 m de espesor). Los criterios para su reconocimiento consisten en lacoloración rojiza de sus fangolitas y su posición estratigráfica. Se diferencia de laFormación Bajo Barreal (miembro superior) porque esta última se componeprincipalmente de fangolitas grises, mientras que se distingue de la Formación LagunaPalacios por la ausencia de niveles tobáceos y paleosuelos. En su localidad tipo seinterpretó un paleoambiente fluvial con sistemas canalizados de alta sinuosidad conplanicies de inundación bien drenadas, vinculados a un paleoclima semi-árido. Elcontenido paleontológico de restos de dinosaurios permitió definir una edadcomprendida entre el Coniaciano-Maastrichtiano, y afinidades faunísticas con laFormación Allen de la Cuenca Neuquina.","palabras_clave":"FORMACIÓN LAGO COLHUÉ HUAPI|GRUPO CHUBUT|CRETÁCICO SUPERIOR|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18271,"idioma_id":5,"titulo":"De convertidor industrial a depositero polirubro. Trayectoria y actividad productiva de un acopiador de residuos reciclables de Quilmes","resumen":"El trabajo analiza el sector vinculado al reciclaje haciendo centro en el caso de un depósito que acopia y comercializa residuos reciclables en el Municipio de Quilmes. Se estudia el rol que este emprendimiento ocupa en el circuito del reciclaje y las condiciones de los recicladores urbanos ligados a esta empresa como proveedores, la relación con el municipio y las articulaciones territoriales y económicas que se dan a partir del funcionamiento de lo que podemos llamar un subsistema local del reciclaje.","palabras_clave":"INTERMEDIARIOS|RECICLAJE|CIRCUITOS ECONOMICOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18272,"idioma_id":4,"titulo":"Enhancement of amperometric response to tryptophan by proton relay effect of chitosan adsorbed on glassy carbon electrode","resumen":"A simply prepared, low-cost, and sensitive electrochemically activated glassy carbon electrode (GCEa) modified with absorbed chitosan (CHIT) film for quantification of tryptophan (Trp) is reported. Combination of cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) techniques were used for characterization of the electro-oxidation of the amino acid and the electro-analytical performance of the CHIT-modified electrode. The electro-oxidation of Trp involves an irreversible two-electron and two-proton transfer process in both bare and modified electrodes, but the adsorption of CHIT as a polycation onto GCEa produces a &#8776;4-fold increase of the oxidation current of Trp without changing both the oxidation potential and the heterogeneous reaction rate constant, suggesting that the biopolymer behaves as a proton relay species, probably due to hydrogen bonding\/proton acceptor capability of hydroxyl and ether groups of CHIT. Finally, the electro-analytical features of the CHIT-modified electrode as Trp sensor were also evaluated, obtaining a linear response range up to 130 M Trp, sensitivity of 0.68 A M&#8722;1 and detection limit of 0.04 M Trp, with almost no interference of other amino acids.","palabras_clave":"Tryptophan|Chitosan|Modified glassy carbon electrodes|Electro-oxidation|Proton relay"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18273,"idioma_id":4,"titulo":"Pre-harvest rot of pear fruits Golden Russet Bosc caused by Phytophthora lacustris and Phytophthora drechsleri in Argentina","resumen":"Phytophthora lacustris sp. nov and P. drechsleri are reported causing a fruit rot of pear (Pyrus communis) Golden Russet Bosc in Argentina. The oomycetes were isolated from developing brown rots of fruits observed pre-harvest. Phytophthora lacustris and P. drechsleri were identified on the basis of morphology and molecular tests and confirmed as the causal agent by fulfilling Koch´s postulates. P. drechsleri was reported for pear culture in Argentina for the first time.","palabras_clave":"PYRUS COMMUNIS|PHYTOPHTHORA FRUIT-ROT|PREHARVEST ROT OBSERVATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18274,"idioma_id":5,"titulo":"Comparación de las técnicas Likert  y Diferencial Semántico para valorar las actitudes hacia la química de ingresantes a carreras biológicas.","resumen":"Este trabajo tiene como propósito estimar el cambio de las actitudes hacia la química de alumnosde las carreras de Licenciatura en Biodiversidad y Profesorado en Biología que se dictan en la UniversidadNacional del Litoral (Santa Fe-Argentina) en tres momentos: al inicio (1º año), durante (3º año) y al final(5º año) de las carreras antes mencionadas. El instrumento elegido para valorar las actitudes de losestudiantes fue un cuestionario según la escala Likert, encuestándose a la totalidad de alumnos que cursabancada uno de los años analizados (45, 30 y 20 alumnos respectivamente). Los resultados obtenidos indicanque existen diferencias estadísticamente significativas (p&#8804;0.05) entre las actitudes hacia la químicapresentadas por alumnos de 3º y 5º con respecto a los de 1º año, registrándose una evolución actitudinalpositiva mostrada hacia esta disciplina conforme avanza la preparación profesional de los mismos. De losresultados obtenidos se puede inferir que deberían revisarse las metodologías de enseñanza y evaluacióntanto en los últimos años de la escuela secundaria como en los primeros años de la universidad para mejorarla actitud hacia la química de los estudiantes de carreras biológicas al iniciar el estudio de las mismas.","palabras_clave":"ACTITUDES|LIKERT|DIFERENCIAL SEMANTICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18275,"idioma_id":5,"titulo":"ENFERMEDAD CELIACA EN LA PROVINCIA DE MISIONES. PREVALENCIA Y SEGUIMIENTO DE CASOS DETECTADOS EN TRES CENTROS DE REFERENCIA","resumen":"La enfermedad celíaca es una enteropatía crónica inmunomediada precipitada por la ingestión de glutenen individuos genéticamente predispuestos. Los objetivos de este estudio fueron: 1) determinar la prevalencia de enfermedad celíaca en individuos que consultaron durante 2013 por síntomas o factores de riesgo en tres centros de la provincia de Misiones; 2) evaluar la adherencia a la dieta seis meses después del diagnóstico en los celíacos confirmados.","palabras_clave":"ENFERMEDAD CELIACA|TRANSGLUTAMINASA|DIETA SIN GLUTEN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18276,"idioma_id":4,"titulo":"Involvement of endothelins in DOCA-salt hypertension through the modulation of noradrenergic transmission in the rat posterior hypothalamus","resumen":"Brain catecholamines participate in diverse biological functions regulated by the hypothalamus. We have previously reported that endothelin-1 and -3 (ET-1 and ET-3) modulate catecholaminergic activity in the anterior and posterior hypothalamus of normotensive rats. The aim of the present study was to evaluate the interaction between ETs and noradrenergic transmission in the posterior hypothalamus of deoxycorticosterone acetate (DOCA)-Salt hypertensive rats. We assessed the effects of ET-1 and ET-3 on tyrosine hydroxylase activity and expression, neuronal noradrenaline (NA) release, neuronal NA transporter (NAT) activity and expression, monoamine oxidase activity, and NA endogenous content and utilization (as a marker of turn-over) in the posterior hypothalamus of DOCA-Salt hypertensive rats. In addition, levels of ETA and ETB receptors were also assayed in normotensive and hypertensive rats. Results showed that TH activity and total and phosphorylated levels, NAT activity and content, NA release, monoamine oxidase activity, and NA utilization were increased in DOCA-Salt rats. Both ET-1 and ET-3 further enhanced all noradrenergic parameters except for total TH level, and NA endogenous content and utilization. The expression of ETA receptors was increased in the posterior hypothalamus of DOCA-salt rats but ETB receptors showed no changes. Present results show that ET-1 and ET-3 up-regulate noradrenergic activity in the posterior hypothalamus of DOCA-Salt hypertensive rats. Our findings suggest that the interaction between noradrenergic transmission and the endothelinergic system in the posterior hypothalamus may be involved in the development or\/and maintenance of hypertension in this animal model.","palabras_clave":"HYPERTENSION|ENDOTHELINS|POSTERIOR HYPOTHALAMUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18277,"idioma_id":4,"titulo":"Land use changes and sediment yield on a hilly watershed in Central-East Argentina","resumen":"Watershed management strategies need suitable techniques to be available in order to quantify sediment yield, among other relevant issues. The aim of this work was to estimate the sediment yield on a hilly watershed, for two different land use scenarios (years 1966 and 2011) and rainfall events (106 mm and 65.5 mm). The Modified Universal Soil Loss Equation (MUSLE) was used to estimate the sediment yield produced by a single rainfall on the watershed of the Belisario Creek, placed on the SouthWest of the Buenos Aires province, Argentina. The information was processed using the Geographic Information System Idrisi Taiga ®. Modeling the 45-years distant land use scenarios allowed to estimate the high level of degradation that is currently taking place on the watershed. Also, we detected different responses through different areas of the watershed; the same rainfall event in the 2011 land use scenario compared to the 1966 scenario showed a 400 % increment on sediment yield in the upper sub-watersheds, together with almost a 100 % of increment near the sink. Here we propose the urgent need to elaborate a sustainable plan for the watershed of the Belisario Creek, in order to establish action criteria that could help improve natural resources management. The methodology used could be also applied to neighbor watersheds with similar characteristics in the region.","palabras_clave":"GIS|MUSLE|SOIL LOSS|TERRITORIAL MANAGEMENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18278,"idioma_id":4,"titulo":"Topological entropy and Renormalization Group flow in 3-dimensional spherical spaces","resumen":"We analyze the renormalization group (RG) flow of the temperature  independent term of the entropy in the high temperature limit  eta\/a&lt;&lt;1 of a massive field theory in 3-dimensional spherical  spaces M_3 with constant curvature 6\/a^2. For masses lower than  2pi\/eta, this term can be identified with the free energy of the same  theory on M_3 considered as a 3-dimensional Euclidean space-time. The  non-extensive part of this free energy, S_hol, is generated by the  holonomy of the spatial metric connection. We show that for homogeneous  spherical spaces the holonomy entropy S_hol decreases monotonically when  the RG scale flows to the infrared. At the conformal fixed points the  values of the holonomy entropy do coincide with the genuine topological  entropies recently introduced. The monotonic behavior of the RG flow  leads to an inequality between the topological entropies of the  conformal field theories connected by such flow, i.e. S_top^UV &gt;  S_top^IR. From a 3-dimensional viewpoint the same term arises in the  3-dimensional Euclidean effective action and has the same monotonic  behavior under the RG group flow. We conjecture that such monotonic  behavior is generic, which would give rise to a 3-dimensional  generalization of the c-theorem, along the lines of the 2-dimensional  c-theorem and the 4-dimensional a-theorem. The conjecture is related to  recent formulations of the F-theorem. In particular, the holonomy  entropy on lens spaces is directly related to the topological R´enyi  entanglement entropy on disks of 2-dimensional flat spaces.","palabras_clave":"TOPOLOGICAL ENTROPY|RENORMALIZATION GROUP|SPHERICAL SPACES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18279,"idioma_id":4,"titulo":"Comparison of phenotypic tests for detecting penicillin G resistance with presence of blaZ gene in Staphylococcus aureus isolated from bovine intramammary infections","resumen":"        Staphylococcus aureus is the most  prevalent mastitis pathogen in dairy herds worldwide. Penicillin (P) has been  considered the drug of choice for treating S. aureus intramammary infections (IMI); however, resistant  isolates were early detected and its prevalence reported to vary widely between  countries. Mastitis diagnostic laboratories usually perform disc diffusion (DD)  or agar dilution tests to determine S. aureus susceptibility to P.  Detection of the blaZ gene by PCR is considered the reference method,  since it correlates well with &#946;-lactamase production. Few studies describe the  relationship between genotypic and phenotypic methods for detecting P  resistance in S. aureus isolated from bovine IMI. However, there is no  information about comparison of DD test with presence of blaZ gene.  Therefore, the aim of this study were to compare six phenotypic methods for  penicillinase detection against a PCR assay for blaZ in S. aureus isolated  from bovine IMI and to determine the accuracy and performance of DD and minimal inhibitory concentration (MIC) considering  detection of blaZ as reference method.  Highest agreement rates were found for DD, MIC, Diatabs and Cefinase. No  dubious results were obtained with Diatabs and Cefinase methods. All methods  carried out, except the iodometric (I) method, yielded very low numbers of  false positive results; while disc diffusion &nbsp;method and MIC yielded the  lowest numbers of false negative results. Most isolates with MICs &#8805;0.25 µg\/ml  and inhibition zone diameters (IZD) &nbsp;&#8804;28 mm (CLSI breakpoints) carried the  blaZ gene. Distribution of &nbsp;MICs and IZDs of isolates according to  the presence or absence of blaZ gene and ROC curve analysis was  performed. For MIC the calculated area under the curve was 0.969 and the cutoff  value &#8805;0.185 µg\/ml; while for DD test area under the curve was 0.961 and the  cutoff value was 28.5 mm. Correlation coefficient between the two tests was  0.87. Two major errors and no very major errors were detected.  In conclusion, the molecular detection of blaZ gene is the only  one method that may indicate the real or potential capacity of producing &#946;-  lactamase in S.aureus. Overall, the DD method can be recommended for  routine clinical practice in veterinary laboratories.  ","palabras_clave":"STAPHYLOCOCCUS AUREUS|PENICILLIN |DISC DIFFUSION TEST |BLAZ GENE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18280,"idioma_id":4,"titulo":"Wang-Landau algorithm for entropic sampling of arch-based microstates in the volume ensemble of static granular packings","resumen":"We implement the Wang-Landau algorithm to sample with equal probabilities the static configurations of a model granular system. The 'non-interacting rigid arch model' used is based on the description of static configurations by means of splitting the assembly of grains into sets of stable arches. This technique allows us to build the entropy as a function of the volume of the packing for large systems. We make a special note of the details that have to be considered when defining the microstates and proposing the moves for the correct sampling in these unusual models. We compare our results with previous exact calculations of the model made at moderate system sizes. The technique opens a new opportunity to calculate the entropy of more complex granular models.","palabras_clave":"GRANULAR|STATISTICS|ENTROPY|ARCHES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18281,"idioma_id":5,"titulo":"Crianza y niñez en dos comunidades indígenas de la Argentina (qom y mbyá)","resumen":"La antropología sudamericana se ha dedicado en las últimas décadas con creciente ímpetu a las investigaciones con niños y niñas en diversos contextos. En nuestras indagaciones etnográficas con niños y niñas de comunidades indígenas de las tierras bajas y altas sudamericanas, hemos considerado de especial relevancia las categorías que delimitan socialmente los diversos modos de ser niño y niña, para facilitar la ruptura con los modelos monolíticos de abordaje de la niñez. En este trabajo, nos proponemos dar cuenta de esta primera etapa de vida, delimitándola en primer lugar desde sus referencias nominales y, en segundo lugar, desde los procesos de crianza y las experiencias formativas en las que los niños y las niñas participan. Así, pondremos especial atención a la red de relaciones sociales en que se desarrolla este período, contemplando cuestiones relativas a la lengua, la religión y el juego. El cruce de estos tres intereses temáticos nos permitirá considerar la complejidad de los conocimientos y saberes que se ponen en juego durante el desarrollo dela niñez.","palabras_clave":"NIÑEZ|COMUNIDADES INDÍGENAS|CRIANZA Y EXPERIENCIAS FORMATIVAS|SABERES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18282,"idioma_id":4,"titulo":"Antibacterial activity of Citrus paradisi essential oil","resumen":"The aim of this work was to determine the effectiveness of Grapefruit (Citrus  paradisi) essential oil to inhibit the growth of wild food-borne spoilage  and pathogenic bacterial strains. Additionally, the chemical composition and  physical properties of this essential oil was evaluated. Essential oil was  obtained as a by-product from agro-processing industry in the province of Corrientes,  Argentina.  Monoterpene hydrocarbon limonene representing 93% (v\/v), quantified by gas  chromatography, was the major component of essential oil. Citrus paradisi  essential oil inhibited growth of Escherichia coli, Staphylococcus  aureus, Lactococcus lactis subsp. lactis, Lactococcus  lactis subsp. diacetylactis, Leuconostoc mesenteroides subsp.  dextranicum and Lactobacillus plantarum. The lowest concentration  of essential oil (4.29ppm) was required to inhibit Lactococcus lactis subsp.  lactis 207c VCOR (8.27±0.13 log10  CFU\/ml) according to the Minimum Inhibitory Concentration. The effect of this  oil on growth of wild strain 207c VCOR (9.17±0.024  log10 CFU\/ml) was determined at different times by total count and  spectrophotometric absorption to 560 nm. At the moment of essential oil  injection, the number of microorganisms was 1.29±0.17x109  CFU\/ml and, at 24 hours of contact, only 6.3±0.5x106  CFU\/ml was detected. These results show that oil has a bactericidal effect if  counts with and without addition of essential oil were compared. The loss of  viability was 1.82x109 CFU\/ml under these experimental conditions.  This essential oil has very strong potential applicability as a natural  antibacterial agent for food industry, particularly for pasta manufacture which  is facing serious spoilage problems due to lactic  bacteria activity.","palabras_clave":"Natural preservative|Spoilage control|Essential oil|Lactic acid bacteria"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18283,"idioma_id":5,"titulo":"La problemática del carácter: un contrapunto entre Sigmund Freud y Wilhelm Reich","resumen":".","palabras_clave":"Caracter|Freud |Psicoanalisis|Reich"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18284,"idioma_id":5,"titulo":"Calidad y adulteración en muestras comerciales de pimentón","resumen":"Desde el año 2003 a la fecha se ha efectuado el seguimiento del color, medido en unidades ASTA, y de la presencia de adulterantes en muestras de pimentón (Capsicum annuum L.) comercializadas en establecimientos de Salta Capital. Los análisis realizados durante este año revelan que el 40% de las mismas estabanadulteradas con colorantes extraños a las xantófilas naturales del pimiento, provenientes del rocú (Bixa orellana L.) e identificados como bixina y norbixina por HPLC y espectroscopía UV-Vis. Los análisis indican que la mayoría de las muestras sin adulteración presentan valores de color inferiores a los establecidos por el Código Alimentario Argentino (CAA) de acuerdo con la denominación provista en el envase, e incluso, algunos, por debajo de los autorizados para su comercialización.Por otra parte, se realizaron con fines comparativos determinaciones de color sobre muestras procedentes de cultivares de diferentes variedades de pimiento dedistintas localidades y productores de los Valles Calchaquíes. Finalmente, se intentó establecer las causas por las cuales los valores de color de las muestras comerciales están alejados de los exigidos por el CAA, para lo cual se investigaron los efectos de la molienda y de la temperatura de almacenamiento en la evolución del color con el tiempo.","palabras_clave":"Pimentón|Capsicum annuum|adulteración|color"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18285,"idioma_id":4,"titulo":"A NEW P. PUTIDA INSTRUMENTAL TOXICITY BIOASSAY","resumen":"Here we present a new toxicity bioassay (CO2-TOX), able to detect toxic or inhibitory compounds in water samples, based on the quantification of Pseudomonas putida KT2440 CO2 production. The metabolically produced CO2 was measured continuously and directlyin the liquid assay media, with a potentiometric gas electrode. The optimization studieswere performed using as a model toxicant 3,5-DCP (3,5-dichlorophenol), later heavymetals (Pb2+, Cu2+ or Zn2+), and a metalloid (As5+33 ) were assayed. The response to toxics was evident after 15 min of incubation and at relatively low concentrations (e.g. 1.1 mg\/L of 3,5-DCP), showing that the CO2-TOX bioassay is fast and sensitive. The EC50 values obtained were 4.93, 0.12, 6.05, 32.17 and 37.81 mg\/L for 3,5-DCP, Cu2+, Zn2+, As5+ and Pb2+ respectively, at neutral pH. Additionally, the effect of the pH of the sample and the use of lyophilized bacteria were also analyzed showing that the bioassay can beimplemented in different conditions. Moreover, highly turbid samples and samples with&nbsp;very low oxygen levels were measured successfully with the new instrumental bioassay&nbsp;described here. Finally, simulated samples containing 3,5-DCP or a heavy metal mixture were tested using the proposed bioassay and a standard ISO bioassay, showing that our test is more sensible to the phenol but less sensible to the metal mixtures. Therefore, wepropose CO2-TOX as a rapid, sensitive, low cost and robust instrumental bioassay thatcould perform as an industrial wastewater-process monitor among other applications.","palabras_clave":"ACUTE TOXICITY|LIOPHYLIZED BACTERIA|RESPIROMETRY|CO2 POTENTIOMETRIC ELECTRODE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18286,"idioma_id":5,"titulo":"Modelización de ítems de matrices figurales y pautas específicas propuestas para su construcción","resumen":"Este artículo da a conocer los resultados de la modelización de un Test de Analogías Figurales (TAF) utilizando los aportes conjuntos de la Teoría Clásica de Tests (TCT) y de la Teoría de Respuesta al Ítem (TRI), así como la posterior interpretación de las desventajas y posibles soluciones del diseño de dicho test. Se desarrolla el marco conceptual que dio origen al armado del TAF, así como los estudios realizados con esta prueba al administrarla a dos muestras. Una de las muestras corresponde a un estudio piloto con estudiantes de Psicología, mientras que la otra muestra consistió en estudiantes de carreras artísticas y de diseño. Los resultados principales revelan indicadores favorables de unidimensionalidad y confiabilidad, así como parámetros aceptables de discriminación (a), dificultad (b) y pseudoazar (c). Se discuten las desventajas del diseño de ítems con tres reglas y nuevas especificaciones en cuanto al armado de reactivos matriciales de 2x2.","palabras_clave":"MATRICES|FIGURAS|ÍTEMS|ANALOGÍA|REGLAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18287,"idioma_id":4,"titulo":"Inhibition of water absorption and selective damage to human colonic mucosa induced by Shiga toxin-2 are enhanced by Escherichia coli O157:H7 infection","resumen":"  &amp;amp;lt;!--   \/* Font Definitions *\/  @font-face  \t{font-family:Arial;  \tpanose-1:2 11 6 4 2 2 2 2 2 4;  \tmso-font-charset:0;  \tmso-generic-font-family:auto;  \tmso-font-pitch:variable;  \tmso-font-signature:3 0 0 0 1 0;}  @font-face  \t{font-family:Cambria;  \tpanose-1:2 4 5 3 5 4 6 3 2 4;  \tmso-font-charset:0;  \tmso-generic-font-family:auto;  \tmso-font-pitch:variable;  \tmso-font-signature:3 0 0 0 1 0;}   \/* Style Definitions *\/  p.MsoNormal, li.MsoNormal, div.MsoNormal  \t{mso-style-parent:'';  \tmargin-top:0cm;  \tmargin-right:0cm;  \tmargin-bottom:10.0pt;  \tmargin-left:0cm;  \tmso-pagination:widow-orphan;  \tfont-size:12.0pt;  \tfont-family:'Times New Roman';  \tmso-ascii-font-family:Cambria;  \tmso-fareast-font-family:Cambria;  \tmso-hansi-font-family:Cambria;  \tmso-bidi-font-family:'Times New Roman';}  @page Section1  \t{size:612.0pt 792.0pt;  \tmargin:72.0pt 90.0pt 72.0pt 90.0pt;  \tmso-header-margin:36.0pt;  \tmso-footer-margin:36.0pt;  \tmso-paper-source:0;}  div.Section1  \t{page:Section1;}  --&amp;amp;gt;        Shiga  toxin-producing Escherichia coli  (STEC) strains are responsible for a variety of clinical syndromes including  bloody and non-bloody diarrhea, hemorrhagic colitis, and hemolytic uremic  syndrome (HUS). Although multiple serotypes of STEC have been isolated from  hemorrhagic colitis cases, E. coli  O157:H7 is by far the most prevalent serotype associated with HUS. Shiga toxin is  the major virulence factor of E. coli  O157:H7 and is responsible for the more severe symptoms of the infection.  However, the mechanisms involved in the pathogenesis  of diarrhea mediated by Stx2 are not well known. In this study, we have  determined the effects of E. coli  O157:H7 strain 125\/99 wild type (wt) on the human colonic mucosa mounted in an  Ussing chamber. In response to 125\/99wt, an inhibition of water absorption  across human colonic mucosa was observed. Histological sections showed severe  necrosis with detachment of the surface epithelium, mononuclear inflammatory  infiltrate and loss of goblet cells after 1 h of incubation with 125\/99wt. These  alterations were not observed with the isogenic mutant strain lacking stx2 or with the filter-sterilized  culture supernatant from the 125\/99wt strain. These results indicate that the  cell damages in human colon are induced by Stx2, and that Stx2 production is  increased by the interaction with bacterial cells. Identification of host  cell-derived factors responsible for increasing Stx2 can lead to new strategies  for modulating STEC infections.","palabras_clave":"STEC infection|human colon|Shiga toxin|Diarrhea"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18288,"idioma_id":4,"titulo":"Prediction of the Ym factor for livestock from on-farm accessible data","resumen":"Methaneemissionfactor(Ym)isdirectlyinvolvedtocalculatetheworldwidelivestockmethaneinventories,henceitisimportanttorefinetheestimationofthisparameterfordifferentlivestockproductionsystems.ThepurposeofthisworkwastogeneraterefinedmathematicalmodelstopredictCH4 emissionsfromanextensivecompilateddatabaseaton-farmlevelandtocomparethemwithdifferentmodelsalreadyavailableintheliterature.Methaneemissionpredictivemodels(expressedasYm,%grossenergyintake;andmethaneproduction, CH4p, g an1 d1) wherefittedtakenintoaccounttheproductionsystem,thelivestocktypeandthefeedcharacteristicsavailableaton-farmlevelwithinareasonableuncertaintyrange.Inordertodevelopthemodels,onlyeasyavailableparameterswereselectedtofitnewmathematicalmodels.Hence,thefullmodelincluded:ruminanttypes(beefcattle,dairycattle,andsheep),fibresources(freshforage,conservedforage,andstraw)andconcentratelevels(DMbasis)inthediet(Low, o35%;Intermediate,35?65%;High, 465%).FullmodelswereassessedbytheBayesianInformationCriterion(BIC)andtermsthatdidnotreachsignificancelevel(Pr0.05)weredroppedfromthemodel.Furthermore,predictedresultswereassessedthroughcorrelationandregressionanalysesconsideringthemodelsignificance.Modelsdevelopedinthisstudywerecomparedbythedegreeofadjustmentofasimpleregression.AdditiveandtechniquetermswereinitiallydroppedfromthefullmodelusedtopredictYmbecausetheydidnothaveeffectintheprediction(P40.10).Therefore,thefinalequationforModel1was:Ym(a)¼Inter-cept0.243(70.051)DMI(kgd1)þ5.9103(71.17103)NDF(gkg1 DM1)þ5.7103(71.63103)DMD(gkg1 MS1) (BIC¼559).Alltermsofthismodel,interceptfactor(typeofcattlesourceoffibrelevelofconcentrate),DMI,NDF,andDMDweresignificant(Po0.0001).DMIwasthetermwiththegreatestweightinthemodel.ThepredictedYmvaluedecreasedabout0.243percentageunits(Po0.0001)pereachadditionalkginDMI.Whentheequationwascomparedwithpreviouspublicatedmodels,ourmodelshowedasatisfactorydegreeoffitting.In conclusion,thisnewmodelimprovedtheestimationoftheYmfactorfrombeefanddairyproductionsystems,usingdifferentforagequalitycharacteristicsfromon-farmlevelto increaseprecision.","palabras_clave":"METHANE|GREEN HOUSE GASES|PREDICTIVE MODEL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18289,"idioma_id":5,"titulo":"Rotaciones bajo siembra directa en la región pampeana semiárida sur","resumen":"La secuencia de cultivos es uno de los principales reguladores del almacenamiento de carbono y del ciclado de la materia orgánica del suelo en sistemas de agricultura continua bajo siembra directa.","palabras_clave":"SECUENCIA DE CULTIVOS|SISTEMAS DE LABRANZA|CARBONO ORGÁNICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18290,"idioma_id":5,"titulo":"Propiedades edáficas superficiales en sistemas de agricultura de conservación en la región pampeana semiárida sur","resumen":"La agriculturización y la aplicación de labranzas agresivas impactaron negativamente sobre el ambiente y el suelo provocando una pérdida de su calidad. En la exploración de opciones para mitigar o revertir los procesos generados, surgen las prácticas de agricultura de conservación (AC). En este contexto, la siembra directa (SD) se expandió desde la Pampa Húmeda hacia la región semiárida sur reemplazando a otros sistemas de labranza, tanto convencionales como conservacionistas. Aquí, el impacto de la SD sobre la magnitud y dirección de los cambios de las propiedades dinámicas de los suelos no está claramente dilucidado. Se propuso como objetivo determinar los efectos de dos sistemas de AC (SD y labranza reducida, LR) sobre los contenidos de carbono orgánico total (COT) y algunas propiedades físicas asociadas en el horizonte superficial (epipedón) de Paleustoles petrocálcicos. Se tomaron muestras al azar en lotes en producción a tres profundidades diferenciales: 0?5, 5?10 y 10?18 cm, con la finalidad de detectar estratificaciones en los parámetros evaluados. Las determinaciones analíticas incluyeron COT, densidad aparente (Dap), porosidad total (Pt) y distribución por tamaño de poros, diferenciando macroporos (MP), mesoporos (mP) y microporos (µP). A campo, se midió la resistencia a la penetración (RP) y se utilizó el programa InfoStat para el análisis estadístico de los datos obtenidos (N=30). El contraste con LR mostró que SD produjo un desmejoramiento de la condición física del epipedón manifestada por incrementos de la Dap y de la RP y disminuciones de la Pt y del volumen de MP. Las diferencias entre tratamientos fueron particularmente manifiestas por debajo de los 5 cm. Tal como se la ha operado en la región, la SD continua no contribuyó al mejoramiento de las propiedades físicas ni a incrementar el stock de COT en el epipedón en el mediano-largo plazo respecto de LR.","palabras_clave":"SIEMBRA DIRECTA |LABRANZA REDUCIDA|CARBONO ORGÁNICO TOTAL|PROPIEDADES FÍSICAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18291,"idioma_id":4,"titulo":"Aminopropyl-modified mesoporous silica nanospheres for the adsorption of Cr(VI) from water","resumen":"Aminopropyl-functionalized mesoporous silica spherical particles were obtained  through post-synthetic route. The suitability of this material as an adsorbent for heavy metals from aqueous media was tested by Cr(VI) adsorption experiments performed at various pH conditions, chromium concentrations and time. The synthesized particles were characterized before and after functionalization by X-ray diffraction at low angles,nitrogen adsorption?desorption isotherms, infrared Fourier transform spectroscopy, scanning electron microscopy and thermogravimetric analysis. It was found that Cr(VI) adsorption occurs more efficiently in the pH range between 2 and 3. As a consequence of the nanometer scale of the particles, concentration profiles do not develop inside of them and thus there are no diffusional restrictions within the pores, leading to a higher  Cr(VI) adsorption than that previously reported for similar systems. Chromium  desorption for material reutilization was carried out in basic media. Results showed that the amino groups were grafted successfully without mesostructure damage. These groups are essential for the metal ion removal and no significant leaching was observed after fouruse\/regeneration\/use cycles. The batch equilibrium data fitted well the Langmuir isotherm with a maximum adsorption capacity of 87.1 mg\/g at 25ºC. A discussion about the relationship between structure and its behavior as adsorbent, including regeneration and reusability, is given.","palabras_clave":"ORDERED MESOPOROUS SILICA|SPHERICAL PARTICLES|ADSORPTION|HEXAVALENT CRHOMIUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18292,"idioma_id":5,"titulo":"DESCOMPACTACIÓN DE UN SUELO FRANCO LIMOSO. EFECTOS   SOBRE LAS PROPIEDADES FÍSICAS.","resumen":"Si bien la siembra directa (SD) tiene como objetivo reducir los impactos de la agricultura sobre el suelo, debido a la ausencia de labranzas y presencia de cobertura permanente, existen numerosas evidencias respecto a procesos de degradación física (densificaciones) determinados por sucesivos años de producción bajo este sistema, particularmente en suelos con alta susceptibilidad (textura superficial franco limosa). El objetivo del trabajo fue evaluar los efectos de la descompactación de un suelo de textura franco limosa bajo SD continua sobre algunas propiedades físicas y cuantificar la perdurabilidad de los mismos. Se utilizaron parcelas completamente aleatorizadas con dos tratamientos: 1) Siembra directa subsolada, y 2) Siembra directa sin subsolar. Los parámetros evaluados fueron: densidad aparente (DAP), resistencia mecánica (RM), humedad gravimétrica (HG) hasta 30 cm de profundidad, con intervalos de 5 cm, e infiltración básica superficial (IB). La densidad aparente no mostró diferencias significativas por efecto del tratamiento. La resistencia mecánica permitió identificar capas densificadas que fueron observadas a campo y mostró diferencias significativas en todas las profundidades evaluadas hasta los 4 meses post-labor. Sin embargo, a los 8 meses de realizada la descompactación, sólo se mantuvieron estos efectos en el estrato de 10-20 cm, y se detectó un aumento significativo de la infiltración básica (134%) en el tratamiento subsolado respecto al testigo. Se concluyó que los parámetros resistencia mecánica e infiltración básica resultaron sensibles para evaluar la perdurabilidad de los efectos de la descompactación.","palabras_clave":"Descompactación|Siembra directa|subsolador"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18293,"idioma_id":5,"titulo":"Marasmiellus volvatus (Marasmiaceae, Agaricomycetes) primer registro en Argentina de una especie poco conocida","resumen":"Marasmiellus&nbsp; volvatus&nbsp; es&nbsp;&nbsp; una&nbsp; especie&nbsp;&nbsp; peque?na,&nbsp; pero&nbsp;&nbsp; llamativa,&nbsp;&nbsp; que&nbsp; se&nbsp;&nbsp; encuentra&nbsp;&nbsp; pocas&nbsp; veces&nbsp; registrada&nbsp;&nbsp; en&nbsp;&nbsp; el&nbsp;&nbsp; mundo.&nbsp; Se&nbsp; caracteriza&nbsp; por sus&nbsp; basidiomas&nbsp; completamente&nbsp; blancos,&nbsp; píleo&nbsp; sulcado,&nbsp; láminas&nbsp; sin&nbsp; intervenosas&nbsp;&nbsp; y&nbsp; estípite&nbsp;&nbsp; con&nbsp; una&nbsp; volva&nbsp; en&nbsp;&nbsp; la&nbsp;&nbsp; base.&nbsp; La&nbsp; especie&nbsp;&nbsp; más&nbsp; próxima, M.&nbsp; coilobasis,&nbsp; se&nbsp;&nbsp; diferencia&nbsp;&nbsp; por&nbsp; la&nbsp;&nbsp; presencia&nbsp;&nbsp; de&nbsp;&nbsp; láminas&nbsp; con&nbsp; intervenosas&nbsp;&nbsp; y&nbsp; por&nbsp; los&nbsp; pleurocistidios&nbsp;&nbsp; y&nbsp; esporas&nbsp;&nbsp; de&nbsp;&nbsp; mayor&nbsp; tama ?no. Esta&nbsp;&nbsp; es&nbsp;&nbsp; la&nbsp;&nbsp; primera cita&nbsp; de&nbsp;&nbsp; M.&nbsp; volvatus&nbsp; para&nbsp;&nbsp; Argentina,&nbsp; y&nbsp; es&nbsp;&nbsp; el&nbsp;&nbsp; registro&nbsp; más&nbsp; austral&nbsp;&nbsp; de&nbsp;&nbsp; la&nbsp;&nbsp; especie.&nbsp; En&nbsp; este&nbsp;&nbsp; trabajo&nbsp;&nbsp; se&nbsp;&nbsp; describe&nbsp; e&nbsp; ilustra&nbsp;&nbsp; a&nbsp; M.&nbsp; volvatus&nbsp; y&nbsp; se&nbsp;&nbsp; presenta&nbsp; una clave&nbsp; de&nbsp;&nbsp; identificación&nbsp;&nbsp; de&nbsp;&nbsp; la&nbsp;&nbsp; sección&nbsp;&nbsp; Candidi&nbsp; con&nbsp; las&nbsp; especies&nbsp; más&nbsp; próximas","palabras_clave":"FUNGI|TRICHOLOMATACEA |CANDIDI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18294,"idioma_id":4,"titulo":"Influence of defects on the irreversible phase transition in Fe-Pd ferromagnetic shape memory alloys","resumen":"In Fe?Pd ferromagnetic shape memory alloys a face-centered tetragonal (fct) martensite can be obtained when cooling the face-centeredcubic austenite through the martensite transition. Nevertheless, further irreversible transformation on cooling into a body-centered tetragonal (bct)martensite needs to be prevented in order to retain the shape memory properties. Differential scanning calorimetry experiments demonstrate that hightemperature thermal treatments stabilize the fct phase, reducing the fct?bct transformation temperature. A large misfit between the cell parameters offct and bct phases was determined by neutron diffraction, pointing to the critical role of dislocations in the accommodation of both phases. Thepresence of dislocations and its dynamics was analyzed by mechanical spectroscopy, and a relaxation peak at 443 K related to the dislocation movementwas identified. The driving force of the relaxation process can be proposed as a dislocation dragging mechanism controlled by the migration ofvacancies without break-away. Defects such as dislocations and vacancies have been shown to play an important role in changing the irreversiblephase transformation temperature. A reduction in the dislocation density reduces the irreversible transformation temperature and so increasesthe stability range of the alloy.","palabras_clave":"FE-PD|FERROMAGNETIC SHAPE MEMORY ALLOYS|MARTENSITIC TRANSFORMATION|DISLOCATION DYNAMICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18295,"idioma_id":5,"titulo":"Programa de Monitoreo de Elementos Combustibles tipo MTR, gastados en reactores experimentales, en sitios de almacenamiento interino prolongado en agua.","resumen":"Los elementos combustibles tipo MTR gastados, provenientes de reactores experimentales argentinos, se depositan bajo agua en almacenamiento interino.  Durante el período 1996-2000 la Argentina participó de Proyectos de Investigación coordinados por el Organismo Internacional de Energía Atómica sobre ?Corrosión acuosa de elementos combustibles de aluminio gastados?, realizando el monitoreo de la corrosión de los combustibles en instalaciones de los reactores RA1, RA3 y RA6 y en canales de la Facilidad de Almacenamiento Central ubicada en el Área de Gestión Ezeiza.   Siguiendo los lineamientos del programa coordinado por la OIEA, actualmente en nuestro país se continúa con el monitoreo de la corrosión de los combustibles gastados en los reactores RA1, RA3 y RA6 y en la instalación FACIRI (Facilidad de Almacenamiento de Combustible Irradiados de Reactores de Investigación).","palabras_clave":"ALEACION AA6061|ALMACENAMIENTO INTERINO|ELEMENTO COMBUSTIBLE MTR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18296,"idioma_id":4,"titulo":"Study of Sperm Evaluation Parameters to Estimate Cryopreserved Bovine Semen Fertility","resumen":"In cattle production, reproductive biotechnologies such as artificialinsemination with Cryopreserved semen samples show the same performanceas insemination with fresh semen. The most representative method to evaluatesemen fertilizing capability is through the results obtained by in vivo fertility.However, as it is difficult to apply this method in practice, routine laboratory testscan be used to evaluate semen quality. The aim of this work was to evaluatefunctional spermatic parameters in cryopreserved bovine semen samples frommales presenting high and low field fertility rates. Semen samples were obtainedfrom bulls presenting low or high fertility in a program of artificial insemination.Routine and functional parameters were determined in both groups. As regardsroutine tests, no significant differences were observed in progressive motilityand vigor between samples of animals with high and low fertility in vivo, butdifferences were detected in vitality and acrosome integrity (p<0.05). Withinfunctional tests, no differences were detected in thermo resistance andcapacitation induction, but HOS test, acrosomal reaction induction and IVFshowed significant differences (p<0.05). These results assert that routineparameters (progressive motility and vigor) have a limited value to predict fieldfertility. Therefore, the incorporation of some functional tests may offer a betterestimation of fertilizing capability.","palabras_clave":"Bull sperm|Semen fertility|Functional parameters |In vitro fertilization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18297,"idioma_id":4,"titulo":"Line defects and quantum Hall plateaus in graphene","resumen":"Line defects in graphene can be either tailored-growth or arise naturally and are at the center of many discussions. Here we study the multiterminal conductance of graphene with an extended line defect in the quantum Hall regime analyzing the effects of the geometry of the setup, disorder and strain on the quantum Hall plateaus. We show that the defect turns out to affect the local and non-local conductance in very different ways depending on the geometrical configuration. When the defect is parallel to the sample edges one gets an equivalent circuit formed by parallel resistors. In contrast, when the defect bridges opposite edges, the Hall conductance may remain unaltered depending on the geometry of the voltage\/current probes. The role of disorder, strain and the microscopic details of the defect in our results is also discussed. We show that the defect provides a realization of the electrical analog of an optical beam splitter. Its peculiar energy dependent inter-edge transmission allows it to be turned on or off at will and it may be used for routing the chiral edge states.","palabras_clave":"GRAPHENE|QUANTUM HALL EFFECT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18298,"idioma_id":4,"titulo":"Living on an island: characterization of the encrusting fauna of large pectinid bivalves from the Lower Cretaceous of the Neuquén Basin, west-central Argentina","resumen":"Exposed mollusc shells  may act as benthic islands in soft bottoms and the analysis of their encrusting  faunas provides unique palaeoecological information. In the lower Valanginian  of the Agrio Formation (Neuquén Basin, west-central Argentina), the large pectinid  Prohinnites acted as a benthic island  on soft substrates. Inequivalved Prohinnites  adults with small, smooth cementing scars on the right valve suggest that a  free reclining life habit followed the epibyssate juvenile and cementing phases.  The encrusting fauna on Prohinnites was  studied taxonomically and palaeoecologically by means of a quantitative  approach. Over 90% of valves presented encrusters. Encrustation was equally  common in both valves. Internal encrustation was rare. The left umbonal region was  less encrusted probably due to sediment accumulation or early colonization by  soft-bodied taxa. The fauna was composed of 14 encrusting taxa, including oysters,  serpulids, sabellids and cyclostome bryozoans. Oysters exceed 50% of the total  abundance, but serpulids and bryozoans were more diverse. Serpulids and  particularly oysters showed a gregarious life habit. Few interactions took  place among encrusters and most were post  mortem, involving the overgrowth of already dead oysters. The oysters were  early settlers which took advantage of their gregarious behaviour to rapidly  cover available hard surfaces. However, they were unable to exclude bryozoans  and polychaetes, which settled on the pectinid?s valves regardless of the  presence of oysters. Hence, the studied fauna corresponds to a climax community  that was structured by larval abundance rather than by competitive  interactions; oysters settled first and replenished themselves while  polychaetes and bryozoans settled over or alongside them.","palabras_clave":"encrustation|benthic island|Prohinnites|gregariousness|hard substrate fauna"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18299,"idioma_id":4,"titulo":"Synthesis and characterization of hydrogels from 1-vinylimidazole. Highly resistant co-polymers with synergistic effect","resumen":"Monomers N, N-(dimethyl) amine ethyl methacrylate (DMAEMT) and N-[3 - (dimethylamine) propyl] methacrylamide (DMAPMD) were co-polymerized with 1-vinylimidazole (VI) in different proportions and crosslinked with N,N´-methylenebisacrylamide (BIS) in aqueous phase, to yield highly  resistant hydrogels. The polymeric products were studied by swelling kinetics, solvent diffusion within the crosslinked network, thermal decomposition, infrared spectroscopy (FTIR), variable pressure  scanning electron microscopy (VP-SEM), and mechanical and rheological tests. The incorporation of VI in the polymerization reaction led to beneficial changes in the properties of the final materials such as  improvement in the resistance of the materials and increase in the percentage of deformation capable of withstanding elongation before breaking. All VI-containing products were mechanically strong with  respect to homo-polymers (DMAPMD 100% and DMAEMT 100%). The most resistant products were DMAPMD-co-VI 60% and DMAEMT-co-VI 60%. A synergistic effect with the addition of VI is revealed by Young´s modulus that increases 5 and 10 times regarding the hydrogels yielded from pure  monomers, respectively.","palabras_clave":"POLYMERS|CHEMICAL SYNTHESIS|MECHANICAL TESTING|MECHANICAL PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18300,"idioma_id":4,"titulo":"Molecular structure effects on the post irradiation diffusion in polymer gel dosimeters","resumen":"Polymer geldosimetershavespecific advantagesforrecording3Dradiationdosedistributionindiag-  nostic andtherapeuticmedicalapplications.But,eveninsystemswherethe3Dstructureisusually  maintained forlongperiodsoftimeafterirradiation,itisstillnotpossibletoeliminatethediffusionof  the differentspeciesintheregionsofdosegradientswithinthegel.Asaconsequence,informationofthe  dose losesqualityovertime.Inthepursuitofasolutionandtoimprovetheunderstandingofthis  phenomenon anovelsystembasedonitaconicacidandN-N&#8242;-methylene-bisacrylamide(BIS)ishereby  proposed. Effectsofchangesinthechemicalstructureofthemonomersoverthedosimetricsensitivity  and overthepost-irradiationdiffusionofspecieswasstudied.Inthisstudy,oneofthecarboxylicgroups  of theitaconicacidmoleculewasmodified withanilinetoobtainmoleculeswithsimilarreactivitybut  different molecularsizes.Then,dosimetersbasedonthesemodified speciesandontheoriginalITA  molecules wereirradiatedinanX-raytomographyapparatusatdifferentdosesupto173Gy.Afterwards,  the resultingdosimeterswerecharacterizedbyRamanspectroscopyandopticalabsorbanceinorderto  study theirfeasibilityandcapabilitiesasdosimetricsystems,andbyoptical-CTtoanalyzethepostir-  radiation diffusion","palabras_clave":"Polymer geldosimeter|dosimetry|diffusion|itaconic acid"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18301,"idioma_id":4,"titulo":"Solid-state studies of the crystalline\/amorphous character in linear Poly(ethylenimine hydrochloride) (PEI-HCl) polymers and their copper complexes","resumen":"Linear poly(ethylenimine hydrochloride) (PEI·  HCl) polymers with different molecular weights (22, 87, and  217 kDa) and their copper complexes (Cu&#8722;PEI) were studied  with particular attention to the crystalline\/amorphous  character of the polymeric chains in lyophilized and crystallized  samples by using 1D and 2D solid-state nuclear magnetic  resonance, X-ray photoelectron spectroscopy, and X-ray  diffraction techniques. Different 13C{1H} cross-polarization  and magic angle spinning experiments using delayed contact  time, 1H dipolar filter and 1H spin-lock filter were crucial to  determine the different mobility domains in the crystallized and lyophilized samples of PEI·HCl and Cu&#8722;PEI. 13C direct  polarization experiments allowed the quantification of the crystalline\/amorphous segments in each sample. The lyophilization  process produced an increase in the amorphous fraction, even when some ordered domains were present, whereas the  coordination of copper\/sulfate ions produced a significant decrease in the mobility of polymer chains, leading to homogeneous  and ordered materials even when Cu was desorbed.","palabras_clave":"PEI POLYMERS|SOLID-STATE|COPPER COMPLEXES|NMR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18302,"idioma_id":4,"titulo":"The origin of groundwater composition in the Pampeano Aquifer underlying the Del Azul Creek basin, Argentina","resumen":"The Pampean plain is the most productive region in Argentina. The Pampeano Aquifer beneath the Pampean plain is used mostly for drinking water. The study area is the sector of the Pampeano Aquifer underlying the Del Azul Creek basin, in Buenos Aires province. The main objective is to characterize the chemical and isotopic compositions of groundwater and their origin on a regional scale. The methodology used involved the identification and characterization of potential sources of solutes, the study of rain water and groundwater chemical and isotopic characteristics to deduce processes, the development of a hydrogeochemical conceptual model, and its validation by hydrogeochemical modelling with PHREEQC. Groundwater samples come mostly from a two-depth monitoring network of the ?Dr. Eduardo J. Usunoff? Large Plains Hydrology Institute (IHLLA). Groundwater salinity increases from SW to NE, where groundwater is saline. In the upper basin groundwater is of the HCO3-Ca type, in the middle basin it is HCO3-Na, and in the lower basin it is ClSO4?NaCa and Cl?Na. The main processes incorporating solutes to groundwater during recharge in the upper basin are rain water evaporation, dissolution of CO2, calcite, dolomite, silica, and anorthite; cationic exchange with Na release and Ca and Mg uptake, and clay precipitation. The main processes modifying groundwater chemistry along horizontal flow at 30 m depth from the upper to the lower basin are cationic exchange, dissolution of silica and anorthite, and clay precipitation. The origin of salinity in the middle and lower basin is secular evaporation in a naturally endorheic area. In the upper and middle basins there is agricultural pollution. In the lower basin the main pollution source is human liquid and solid wastes. Vertical infiltration through the boreholes annular space during the yearly flooding stages is probably the pollution mechanism of the samples at 30 m depth.","palabras_clave":"Pampeano Aquifer|Del Azul Creek basin|Groundwater chemistry origin|Isotopic enrichment"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18303,"idioma_id":4,"titulo":"Complementary Sex Determination in the Parasitic Wasp Diachasmimorpha longicaudata","resumen":"We studied the sex determination in Diachasmimorpha longicaudata, a parasitoid braconid wasp widely used as biological control agent of fruit pest tephritid flies. We tested the complementary sex determination hypothesis (CSD) known in at least 60 species of Hymenoptera. According to CSD, male or female development depends on the allelic composition of one sex locus (single-locus CSD) or multiple sex loci (multiple-locus CSD). Hemizygote in-dividuals are normal haploid males, and heterozygotes for at least one sex locus are normal diploid females, but homozygotes for all the sex loci are diploid males. In order to force the occurrence of diploid males in D. longicaudata, we established highly inbred lines and examined their offspring using chromosome counting, flow cytometry, and sex ratio analysis.We found that when mother-son crosses were studied, this wasp produced about 20% of diploid males out of the total male progeny. Our results suggest that this parasitoid may represent the second genus with multiple-locus CSD in Hymenoptera. Knowledge about the sex determination system in D. longicaudata is relevant for the improvement of mass rearing protocols of this species. This information also provides the necessary background forfurther investigations on the underlying molecular mechanisms of sex determination in this species, and a better insight into the evolution of this pathway in Hymenoptera in particular and insects in general.","palabras_clave":"COMPLEMENTARY SEX DETERMINATION|DIACHASMIMORPHA LONGICAUDATA|MULTIPLE SEX LOCI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18304,"idioma_id":5,"titulo":"Comparación morfométrica entre lagunas de la planicie aluvial del río Paraná Medio y La Lomada Norte (Corrientes, Argentina)","resumen":"El desarrollo de la línea de costa (DL) es una medida morfométrica que permite conocer cuantitativamente la forma de la cubeta. El objetivo de este trabajo es comparar el DL de un grupo de lagunas que, aunque se encuentran en una misma región, son geológica y geomorfológicamente distintas. Para ello, se midieron 925 lagunas,correspondientes a la totalidad de cuerpos leníticos de la Lomada Norte, y 1.500 lagunas de la llanura aluvial del río Paraná Medio. Los resultados demostraron que en las primeras existe un predominio de lagunas circulares que evolucionan a formas más complejas, mientras que en las segundas, en su mayoría, son lagunas de forma alargada evolucionando a ovales o circulares.","palabras_clave":"CORRIENTES|DESARROLLO DE LÍNEA DE COSTA|LAGUNAS|MORFOMETRÍA|RÍO PARANÁ"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18305,"idioma_id":4,"titulo":"Revealing the Role of Cationic Displacement in Potassium-Sodium Niobate Lead-free Piezoceramics by adding W6+ ions","resumen":"The effect of the structural modifications induced by the replacement of the B sites with W6+ ions in (K0.44Na0.52Li0.04)[(Nb0.86Ta0.10Sb0.04)1xW5x\/6]O3 lead free ceramics is investigated. Here we show the coexistence between a tetragonal symmetry (T) and an orthorhombic symmetry (O) in the perovskite structure, which is tuned by varying the doping level. In addition, this polymorphic behaviour is accompanied by the appearance of a secondary phase, which can be detected through XRD and Raman results. A correlation between the presence of both structural features and the W6+ content has been evaluated, and therefore this lead free system reveals a transition from a normal ferroelectric to a  ?relaxor-like? ferroelectric due to the cation disorder in the perovskite-structure in doped samples. A large diffusivity value (g) has been attained when the x value reached 0.05 owing to the involved O?T  polymorphic phase, as well as due to the appearance of a secondary phase. The experimental proof  makes clear that the role of the secondary phase is to capture the alkali ions of the (KNa)NbO3-based  system, provoking a cation disorder in the perovskite-structure matrix. The significance of this work lies  in evaluating whether such a material can benefit the understanding of (KNa)NbO3-based ceramics and  the expansion of their application range.","palabras_clave":"Lead- free materials|Potassium-Sodium Niobate phase|Piezoelectric ceramics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18306,"idioma_id":4,"titulo":"Enhanced Gap Fraction Extraction from Hemispherical Photography","resumen":"Canopy structure can be estimated using gap fraction (GF) data, which can be directly measured with hemispherical photography. However, GF data accuracy is affected by sunlit canopy, multiple scattering, vignetting, blooming, and chromatic aberration. Here, we present an algorithm to classify hemispherical photography, whose aim is to reduce errors in the extraction of GF data. The algorithm, which was implemented in free software, uses color transformations, fuzzy logic, and object-based image analysis. The results suggest that color and texture, rather that only brightness, can be used to extract GF data","palabras_clave":"FORESTRY|FUZZY LOGIC|FISHEYE PHOTOGRAPHY|IMAGE CLASSIFICATION|IMAGE TEXTURE ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18307,"idioma_id":4,"titulo":"Specific preferences in \tlineage choice and phenotypic plasticity of glioma stem cells under bmp4 and \tnoggin influence","resumen":"Although BMP4-induced differentiation of glioma stem cells (GSCs) is well recognized, details of the cellular responses triggered by this morphogen are still poorly defined. In this study, we established several GSC-enriched cell lines (GSC-ECLs) from high-grade gliomas. The expansion of these cells as adherent monolayers, and not as floating neurospheres, enabled a thorough study of the phenotypic changes that occurred during their differentiation. Herein, we evaluated GSC-ECLs´ behavior toward differentiating conditions by depriving them of growth factors and\/or by adding BMP4 at different concentrations. After analyzing cellular morphology, proliferation and lineage marker expression, we determined that GSC-ECLs have distinct preferences in lineage choice, where some of them showed an astrocyte fate commitment and others a neuronal one. We found that this election seems to be dictated by the expression pattern of BMP signaling components present in each GSC-ECL. Additionally, treatment of GSC-ECLs with the BMP antagonist, Noggin, also led to evident phenotypic changes. Interestingly, under certain conditions, some GSC-ECLs adopted an unexpected smooth muscle-like phenotype. As a whole, our findings illustrate the wide differentiation potential of GSCs, highlighting their molecular complexity and paving a way to facilitate personalized differentiating therapies.","palabras_clave":"glioma|stem cells|differentiation|BMP4"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18308,"idioma_id":4,"titulo":"A therapy-grade protocol for differentiation of pluripotent stem cells into mesenchymal stem cells using platelet lysate as supplement","resumen":"    INTRODUCTION:   Mesenchymal   stem cells (MSCs) are a promising source of cells for regenerative   therapies. Although they can be isolated easily from several tissues,   cell expansion is limited since their properties are lost with   successive passages. Hence, pluripotent derived MSCs (PD-MSCs) arise as a   suitable alternative for MSC production. Nevertheless, at present,   PD-MSC derivation protocols are either expensive or not suitable for   clinical purposes.  METHODS:   In   this work we present a therapy-grade, inexpensive and simple protocol   to derive MSCs from pluripotent stem cells (PSCs) based on the use of   platelet lysate (PL) as medium supplement.  RESULTS:   We   showed that the PD-MSCPL expressed multiple MSC markers, including   CD90, CD73, CD105, CD166, and CD271, among others. These cells also show   multilineage differentiation ability and immunomodulatory effects on   pre-stimulated lymphocytes. Thorough characterization of these cells   showed that a PD-MSCPL resembles an umbilical cord (UC) MSC and differs   from a PSC in surface marker and extracellular matrix proteins and   integrin expression. Moreover, the OCT-4 promoter is re-methylated with   mesenchymal differentiation comparable with the methylation levels of   UC-MSCs and fibroblasts. Lastly, the use of PL-supplemented medium   generates significantly more MSCs than the use of fetal bovine serum.  CONCLUSIONS:   This protocol can be used to generate a large amount of PD-MSCs with low cost and is compatible with clinical therapies.","palabras_clave":"PLURIPOTENT STEM CELLS|MESENCHYMAL STEM CELLS|THERAPY-GRADE PROTOCOL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18309,"idioma_id":5,"titulo":"Aplicaciones de Modos Deslizantes para el Control de Movimiento de un Robot Laparoscópico Experimental","resumen":"? En este trabajo se presenta la implementación de dos leyes de control por modos deslizantes aplicada en el control demovimiento del robot laparoscópico desarrollado por el Grupo Robótica y Sistemas Integrados de la Facultad de Ciencias Exactas,Físicas y Naturales, Universidad Nacional de Córdoba. Con el objeto de comparar cuantitativamente la respuesta de los controladores seintroducen una serie de índices de bondad para la evaluación de la respuesta del sistema ante entradas complejas y perturbaciones. Sepresentan los modelos cinemático y dinámico del robot, así como los requerimientos específicos de control de trayectoria. Dado que lasleyes de control implementadas requieren contar con referencias de posición y velocidad articular, se comenta una alternativa para lageneración de estados de referencia en tiempo real.","palabras_clave":"Control Dinámico|Control Multivariable|Modos Deslizantes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18310,"idioma_id":5,"titulo":"Comparación in vitro de la difusión iónica de pastas de hidróxido de calcio usadas como medicación intraconducto con diferentes vehículos","resumen":"La medicación intraconducto consiste en la colocación de un medicamento en el interior del conducto radicular. En la actualidad, la pasta de hidróxido  de calcio es la más utilizada. Su mecanismo de acción se basa en la disociación de iones oxhidrilos y calcio, responsables de efectos antibacterianos y  de reparación tisular. El objetivo de este trabajo fue comparar la difusión de iones calcio y oxhidrilos de la pasta de hidróxido de calcio en el tiempo,  utilizando como vehículo agua tridestilada, polietilenglicol y gel de aloe vera. Se utilizaron 45 caninos, se realizó radiografías preoperatorias, aperturas,  determinación de la longitud de trabajo para la preparación biomecánica de los conductos. Se rellenaron los especímenes con cada una de las pastas  tomando radiografías postoperatorias. Se colocaron las muestras en un medio de análisis almacenándolas en estufa a 37ºC durante 3, 24, 72,168 y 336  horas. Se realizó por triplicado la determinación del pH con pH-metro Metrohm 692 y de la concentración de calcio total utilizando el método espectrofotométrico  (reacción del calcio con cresolftaleína complexona a pH 11). Los datos se analizaron estadísticamente por medio de ANOVA aplicando  el test de LSD (&#945;= 0,05). El comportamiento difusional de las pastas alcalinas con vehículo agua tridestilada y polietilenglicol fue similar en las primeras  etapas de experimentación y difirió en las etapas finales. La pasta alcalina con gel de aloe vera mostró un comportamiento de iones oxhidrilos diferente  en las primeras etapas de experimentación, el comportamiento de iones calcio fue similar hasta las 168 horas","palabras_clave":"MEDICACION INTRACANAL|PH|CALCIO|OXHIDRILOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18311,"idioma_id":4,"titulo":"Morphological and compositional characteristics of bimetallic core@shell nanoparticles revealed by MEIS","resumen":"In this paper we report the application of a suitable methodology to study the morphology, structure and composition of core@shell nanoparticles (NPs) systems with polydispersity in the shell thickness, with subnanometer resolution and good sampling. Through the combination of Medium Energy Ion Scattering with Transmission Electron Microscopy, we perform a systematic investigation on core@shell Au@Ag NPs synthesized by an original wet chemical method. For samples synthesized with baths of different AgNO3 concentrations, the present approach allowed us to determine the NP?s Ag shell thicknesses distribution of about a few nanometers around the Au core.","palabras_clave":"MEIS|Polydisperse nanoparticles|Core@shell nanoparticles|Au@Agl nanoparticles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18312,"idioma_id":4,"titulo":"Cheetah Embryo aggregation in interspecific SCNT improves development but not gene expression","resumen":"The main difficulty to develop in vitro reproduction techniques in wild felids is the unavailability of oocytes. The aim of this study was to evaluate the capacity of domestic cat (Dc, Felis silvestris) oocytes to reprogram the nucleus of cheetah (Ch, Acinonyx jubatus) cells by inter-species SCNT (iSCNT), by using embryo aggregation as a strategy for improving nuclear reprogramming and the cloning technique. Domestic cat oocytes were in vitro matured and subjected to zona pellucida free (ZP-free) SCNT or iSCNT, depending on whether the nucleus donor cell was of domestic cat or cheetah, respectively. ZP-free reconstructed embryos were then cultured in microwells individually (Dc1X and Ch1X groups) or in couples (Dc2X and Ch2X groups). Embryo aggregation improved in vitro development in each species, obtaining 27.4%, 47.7%, 16.7% and 28.3% of blastocyst rates in the Dc1X, Dc2X, Ch1X and Ch2X groups, respectively (p<0.05). Moreover, aggregation improved the morphological quality of blastocysts from the Dc2X over the Dc1X group. Gene expression analysis revealed that Ch1X and Ch2X blastocysts had significantly lower relative expression of OCT4, CDX2 and NANOG than the Dc1X, Dc2X and IVF control groups. The OCT4, NANOG, SOX2 and CDX2 genes were overexpressed in Dc1X blastocysts, but the relative expression of these four genes decreased in the Dc2X, reaching similar relative levels to those of domestic cat IVF blastocysts. In conclusion, cheetah blastocysts were produced using domestic cat oocytes, but with lower relative expression of pluripotent and trophoblastic genes, indicating that nuclear reprogramming could be still incomplete. Despite this, embryo aggregation improved the development of Ch and Dc embryos, and normalized Dc gene expression, which suggest that this strategy could improve full-term developmental efficiency of cat and feline iSCNT embryos.","palabras_clave":"NUCLEAR REPROGRAMMING|INTERSPECIFIC SCNT|AGGREGATION|FELIDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18313,"idioma_id":5,"titulo":"Efectos de factores físicos y químicos sobre la remediación de residuos sólidos contaminados con Cr(VI) por Aspergillus niger: mecanismos de detoxificación","resumen":"Efecto de factores físicos y químicos sobre la remediación de residuos sólidos contaminados con Cr(VI) por Aspergillus niger: mecanismo de detoxificación Cristina Rubio1*, Antonela Márquez1, Soledad Suárez1, Gladys Duca2 1Instituto de Biotecnología. Facultad de Bioquímica, Química y Farmacia. 2Facultad de Medicina. Universidad Nacional de Tucumán. Ayacucho 471 (4000). Tucumán. Argentina. Tel: 54-03814107209. *autor corresponsal: mcrubio@fbqf.unt.edu.ar RESUMEN Aspergillus niger se usó para estudiar la remediación de pulpa de limón contaminada con diferentes concentraciones de Cr(VI):5; 10; 20 y 50 mg\/L; temperaturas: 25; 30 y 35 ºC; números de conidios: 1; 2 y 3 .105 conidios\/g de pulpa y la toxicidad del Cr(VI) sobre el desarrollo del hongo y la producción de poligalacturonasas (EC.3.2.1.15); naringinasa (&#61537; L-ramnosidasa, EC.3.2.1.40 y &#61538; D-glucosidasa, EC.3.2.1.21) y reductasa. El hongo remedió el 100% de la pulpa (80%humedad) contaminada con Cr(VI) a 5; 10 y 20 mg\/L y alcanzó un 99% de Eficiencia, cuando la concentración del metal pesado fue 50mg\/L en las siguientes condiciones: 2.105 conidios\/g de pulpa; 30 ºC y pH 2.5. El Cr(VI) influyó en la maduración de los conidios del hongo(48 h), disminuyó la concentración de proteína intracelular (0.22 mg\/mL) reflejada por la ausencia de bandas proteicas de una PAGE-no desnaturalizante y redujo un 24 y 86 %, la producción de poligalacturonasa (PG) y naringinasa (N), respecto al control (72 h; proteína: 0.25 mg\/mL; PG: 0.17 y N: 0.02 U\/ml). Se determinó actividad específica cromato reductasa (6.3.10-2 U\/mg) y por absorción atómica se verificó que el 97.30 % del Cr(VI) se redujo a Cr(III). Se propone que el mecanismo de detoxificación de Cr(VI) por A. niger es por adsorción del metal a la pared celular y absorción al interior celular. La biorremediación puede suplementar a los tratamientos físicos químicos ya existentes o aquellos que no resultan completamente eficientes, para alcanzar una verdadera remediación. Palabras claves: Aspergillus niger, biorremediación, detoxificación, Cr(VI), residuos sólidos","palabras_clave":"ASPERGILLUS NIGER|BIORREMEDIACION|DETOXIFICACION|Cr(VI)|RESIDUOS SOLIDOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18314,"idioma_id":4,"titulo":"Control of citrus pathogens by protein extracts from Solanum tuberosum tubers","resumen":"A national program for citrus certificationwas started in Argentina in 2005 in order to providehealthy fruits free of toxic residues. In line with thisgoal, the aim of this study was to evaluate the efficacy of natural products, protein extracts obtained from potato tubers for the control of fungi responsible for disease in post-harvest citrus fruits. Different protein fractions were obtained from Solanum tuberosum tubers (IF25, IF50, SF25 and SF50) and their effect were evaluated on Penicillium digitatum and Geotrichum candidum, two citrus-pathogenic fungi. All fractions showed antifungalactivity against both fungi species, the intensity of this activity being dependent on the type of fungus and extract. The fraction IF25 was the most active as an antifungal agent: it inhibited the mycelia growth of both pathogens, the elongation of the germ tube ofP. digitatum and the conidial isotropic growth of G. candidum as well as its polygalacturonase activity.None of the IF25 concentrations were mutagenic in Salmonella typhimurium TA98 or TA100 strains. The efficacy of protein extracts to control P. digitatum andG. candidum growth was tested in artificially inoculated citrus fruits. Extracts were tested built-in to the wax used in citrus industry to coat and protect the fruit. The IF25 extract was effective in inhibiting the growth and developmentof P.digitatum and G. candidum. Consequently, the IF25 extract plus the wax could be used preventively in controlling fungal infection on post-harvest citrus.","palabras_clave":"Potato protein extracts . |Antifungal activity. |Citrus fruit . |Penicillium digitatum . Geotrichum candidum"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18315,"idioma_id":4,"titulo":"Manganite based memristors: Influence of the electroforming polarity on the electrical behavior and radiation hardness","resumen":"We report on the fabrication and characterization of La2\/3Ca1\/3MnO3 manganite-based memristive devices. Polycrystalline manganite thin films were grown by Pulsed Laser Deposition, while metallic electrodes were deposited by sputtering. We show that, depending on the polarity of the initial electroforming, both clockwise and anti-clockwise current?voltage curves can be obtained. We attribute this behavior to the coexistence of different resistive switching mechanisms. We finally evaluate the electrical behavior of our devices after irradiation with high energy oxygen ions. We find no significant difference in the dielectric breakdown voltages between irradiated and non-irradiated devices, indicating that they may present radiation hardness and could be therefore appropriate for space or nuclear applications.","palabras_clave":"oxide thin films|ReRAM memories|radiation hardness"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18316,"idioma_id":4,"titulo":"Quantum Discord and Information Deficit in Spin Chains","resumen":"We examine the behavior of quantum correlations of spin pairs in a finite anisotropic XY spin chain immersed in a transverse magnetic field, through the analysis of the quantum discord and the conventional and quadratic one-way information deficits. We first provide a brief review of these measures, showing that the last ones can be obtained as particular cases of a generalized information deficit based on general entropic forms. All of these measures coincide with an entanglement entropy in the case of pure states, but can be non-zero in separable mixed states, vanishing just for classically correlated states. It is then shown that their behavior in the exact ground state of the chain exhibits similar features, deviating significantly from that of the pair entanglement below the critical field. In contrast with entanglement, they reach full range in this region, becoming independent of the pair separation and coupling range in the immediate vicinity of the factorizing field. It is also shown, however, that significant differences between the quantum discord and the information deficits arise in the local minimizing measurement that defines them. Both analytical and numerical results are provided.","palabras_clave":"Quantum Correlations|Entropic measures|Quantum Discord|Information Deficit|Spin systems"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18317,"idioma_id":4,"titulo":"General splitting methods for abstract semilinear evolution equations","resumen":"In this paper we present a unified picture concerning general splitting mnethods for solving a&nbsp;","palabras_clave":"Lie-Trotter|Splitting integrators|semilinear problems"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18318,"idioma_id":4,"titulo":"Cationic ordering and role of the B-site lanthanide (III) and molybdenum (V) cations on the structure and magnetism of double perovskites Sr2LnMoO6","resumen":"We describe the preparation, crystal structure determination and magnetic properties of a new series of ordered double perovskite oxides Sr 2 LnMoO 6 (Ln = Eu, Gd, Dy, Ho, Er, Yb) with Mo 5+ and Ln 3+ electronic configurations. These compounds have been obtained by solid state reaction under reducing conditions in order to stabilize Mo 5+ cations. Structural characterization by XRPD and NPD was performed when Ln = Ho, Er, Yb and just XRPD for absorbing Ln = Eu, Gd, Dy. At room temperature, an excellent Rietveld fit was obtained for all the samples in a monoclinic symmetry, space group P2 1 \/n, with long-range ordering of Ln and Mo atoms. Magnetic susceptibility measurements show that some of these materials present magnetic ordering below 25 K and the determined effective magnetic moments are consistent with thoseexpected for the pair Ln 3+ ?Mo 5+ . All the phases have negative values of the Weiss temperature indicating dominance of antiferromagnetic interactions.","palabras_clave":"Inorganic compounds|X-ray diffraction|Neutron diffraction|Crystal structure|Magnetic properties"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18319,"idioma_id":4,"titulo":"A new LaCo 0.71(1) V 0.29(1) O 2.97(3) perovskite containing vanadium in octahedral sites: synthesis and structural and magnetic characterization","resumen":"In the course of an investigation to prepare the hypothetic new double perovskite La3Co2VO9 with Co2+ and V5+ in octahedral sites, we obtained the new simple perovskite LaCo0.71(1)V0.29(1)O2.97(3) as the main phase. The pure compound was then synthesized by the citrate decomposition method. The crystal structure was studied by X-ray (PXRD) and powder neutron diffraction (PND). Physical properties were characterized by X-ray absorption spectroscopy (XAS), X-ray emission spectroscopy (XES) and thermogravimetric analysis (TGA). Rietveld refinements were performed in the orthorhombic space group Pnma(#62). Refined cell parameters were a = 5.4762(2) Å, b = 7.7609(2) Å and c = 5.5122(1) Å. Magnetization measurements showed that this perovskite is an antiferromagnet with a Neel temperature of 15 K. At high T the magnetization follows the Curie?Weiss law corrected by temperature independent paramagnetism (TIP) showing an effective magnetic moment of 3.03&#956; B well described by the contribution of Co2+ (HS), Co3+ (IS), V3+ and V4+ ions. The crystallographic formula was refined by PND and oxidation state distribution was determined by the combination of PND, XAS, TGA and magnetic measurements.","palabras_clave":"perovskite|neutron powder diffraction|magnetization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18320,"idioma_id":4,"titulo":"A Belief Revision Approach for Argumentation-based Negotiation Agents","resumen":"Negotiation is an interaction that happens in multi-agent systems when agents have conflicting objectives and must look for an acceptable agreement. A typical negotiating situation involves two agents that cannot reach their goals by themselves because they do not have some resources they need or they do not know how to use them to reach their goals. Therefore, they must start a negotiation dialogue, taking also into account that they might have incomplete or wrong beliefs about theother agent?s goals and resources. This article presents a negotiating agent model based on argumentation, which is used by the agents to reason on how to exchange resources and knowledge in order to achieve his goals. Agents that negotiate have incomplete beliefs about the others, so that the exchange of arguments gives them information that makes it possible to update their beliefs. In order to formalize their proposals in a negotiation setting, the agents must be able to generate,select and evaluate arguments associated with such offers, updating their mental state accordingly. In our approach, we will focus on an argumentation-based negotiation model between two cooperative agents. The arguments generation and interpretation process are based on the belief change operations (expansions, contractions and revisions), and the selection process is a based on a strategy. This approach is presented through a high-level algorithm that has been implemented inlogic programming. We show different theoretical properties associated with this approach, which have been formalized and proved using Coq, a formal proof management system. We also illustrate through a case study the applicability of our approach in order to solve a slightly modified version of the well-known Home Improvement Agents Problem. Moreover,we present different simulations that allow to assess the impact of belief revision on the negotiation process.","palabras_clave":"Argumentation-based Negotiation|Collaborative Agents|Belief Revision|Multi-agent system"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18321,"idioma_id":4,"titulo":"Molecular Chaperones Shape Steroid Receptor Action and Pharmacologic Strategies","resumen":"Chaperone oligomers exist in cell cytosols as preassembled heterocomplexes that function as protein-folding molecular machines able to assemble essential proteins related to families that embrace steroid receptors, protein-kinases, ubiquitin-ligases, and transcription factors, among other families of key proteins. Actually, steroid receptors may be considered a particular subset of transcription factors that can be activated by specific ligands. Some of them are primarily located in the cytoplasm, others are constitutively nuclear, but regardless of their subcellular distribution, they are constantly shuttling between both compartments in a highly dynamic manner. The chaperone heterocomplex associated to steroid receptors is not only involved in the stabilization of their conformation preventing their degradation by the proteasome, but it is also critical for the molecular mechanism of transport of these receptors and their subnuclear redistribution. In this article we summarized some of the general properties of molecular chaperones, in particular those belonging to a subfamily that is highly inducible by thermal shock, the heat-shock proteins, and review the most recent findings performed in the field of soluble protein trafficking, where molecular chaperones play a critical role.","palabras_clave":"HSP90|HSP70|P23|IMMUNOPHILINS|FKBP51|FKBP52|TPR PROTEINS|DYNEIN|STEROID RECEPTORS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18322,"idioma_id":5,"titulo":"Bases Para La Conservación De Las Semillas De Calophyllum brasiliense   (Calophyllaceae)","resumen":"Resumen    En Argentina la especie arbórea Calophyllum brasiliense Cambess (Calophyllaceae) constituye poblaciones en los bordes de esteros y en las selvas higrófilas del río Paraná. Las poblaciones de la margen del río forman parte de ecosistemas fuertemente fragmentados por su asociación a las cotas de inundación del embalse Yacyretá, lo cual las ha llevado a reducir drásticamente su tamaño al punto de encontrarse en riesgo de extinguirse localmente. Uno de los efectos de la fragmentación en las especies vegetales es la producción de semillas en menor cantidad, calidad o ambas. El valor ecológico, medicinal, económico y social de la especie y el estado de sus poblaciones suscitaron interés en conservarla. Una de las estrategias implementadas fue el almacenamiento de sus semillas, las cuales son recalcitrantes. Los objetivos del presente trabajo fueron evaluar tres poblaciones en cuanto a su potencialidad de producir semillas capaces de generar individuos y evaluar la calidad fisiológica en relación al momento de cosecha y al tiempo de almacenamiento bajo cuatro modos de almacenamiento. La población de Puerto Valle produjo semillas de buena calidad que conservaron la viabilidad durante treinta y un semanas cuando se almacenaron con endocarpo, en frascos de vidrio.","palabras_clave":"CALOPHYLLUM BRASILIENSE|SEMILLAS|ALMACENAMIENTO|CONSERVACIÓN|CALIDAD FISIOLÓGICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18323,"idioma_id":4,"titulo":"Maize water use efficiency and evapotranspiration response to N supply under contrasting soil water availability","resumen":"Water use efficiency (WUEg), the quotient between grain yield and crop evapotranspiration (ET), might be increased in maize crops (Zea mays L.) due to N supply. Most research has focused on understanding grain yield response to N supply; so there is little and contradictory information on the influence of N supply on WUEg in water limited environments and on ET response to N supply under contrasting water availability. The objectives of our research were to elucidate whether N supply affects WUEg in water limited environments; and to clarify the expected response to N supply of maize ET and its components under contrasting soil water availability. Maize crops were grown at Balcarce, Argentina during three seasons. Treatments included two water regimes (i.e. rain-fed and irrigated) and two rates of N (i.e. 120&nbsp;kg&nbsp;N&nbsp;ha&#8722;1 or non-fertilized). Measurements included (i) soil water content and intercepted photosynthetically active radiation (iPAR) during the whole crop season, and (ii) grain yield and shoot dry matter at physiological maturity. Crop ET was calculated by means of a water balance and soil evaporation was estimated by means of micro-lysimeters. Our results show that N supply did not influence WUEg in water limited environments; but N supply significantly increased ET (2¨C8%) under all water availability conditions. Maize seasonal ET increments were closely related to the improvement of seasonal iPAR in non-water limited environments, but not in water limited environments. In non-water limited environments, ET response to N supply was mediated by the concomitant effects of iPAR increments on increasing transpiration while reducing evaporation. In water limited environments, ET slightly increased in response to iPAR increments due to N supply. The low ET increment in water limited environments with frequent low superficial soil water content (i.e. ¡Ü2&nbsp;mm&nbsp;cm&#8722;1) was probably not influenced by reductions in evaporation (E); but associated with stomata closure in response to water deficiencies. This is consistent with the fact that N supply did not promote improvements in radiation use efficiency for biomass production (RUEb) in these environments.","palabras_clave":"EVAPORATION|INTERCEPTED PHOTOSYNTHETICALLY ACTIVE|RADIATION|ZEA MAYS L."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18324,"idioma_id":4,"titulo":"Generalized Nonlinear Optimal Predictive Control Using Iterative State-Space Trajectories: Applications to Autonomous Flight of UAVs","resumen":"Model Predictive Control (MPC) is a modern technique that, nowadays, encapsulates different optimal control techniques. For the case of non-linear dynamics, many possible variants can be developed which can lead to new control algorithms. In this manuscript a novel generic control system method is presented. This method can be applied to control, in an optimal way, different systems having non-linear dynamics.  Particularly, in this paper, the proposed technique is presented in the context of developing a control system for autonomous flight of UAVs. This technique can be used for different types of aerial vehicles having any type of generic non-linear dynamics. The presented method is based on the use of iteratively defined optimal candidate state-space trajectories in global state-space. The method uses a generalized linearization process which, opposite to standard methods, does not need to be predefined in a certain equilibrium state but instead it is performed along any arbitrary state. The technique allows the inclusion of constraints with ease.  The presented technique is used as a centralized control system unit that is able to control the full aircraft dynamics without the need of decoupling the system in different reduced modes. The technique is tested by making a Cessna 172 airplane model to perform the following autonomous unmanned maneuvers: climbing at constant speed to a desired altitude, heading change to a desired flight direction, and, coordinate turn.","palabras_clave":"NON-LINEAR MODEL PREDICTIVE CONTROL|OPTIMIZATION|STATE-SPACE TRAJECTORIES PREDICTION|UNMANNED AERIAL VEHICLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18325,"idioma_id":4,"titulo":"Sequence and expression analysis of putative Arachis hypogaea (peanut) Nod factor perception proteins","resumen":"Peanut, like most legumes, develops a symbiotic relationship with rhizobia  to overcome nitrogen limitation. Rhizobial infection of peanut roots occurs  through a primitive and poorly characterized intercellular mechanism.  Knowledge of the molecular determinants of this symbiotic interaction is  scarce, and little is known about the molecules implicated in the  recognition of the symbionts. Here, we identify the LysM extracellular  domain sequences of two putative peanut Nod factor receptors, named  AhNFR1 and AhNFP. Phylogenetic analyses indicated that they correspond  to LjNFR1 and LjNFR5 homologs, respectively. Transcriptional analysis  revealed that, unlike LjNFR5, AhNFP expression was not induced at 8 h  post bradyrhizobial inoculation. Further examination of AhNFP showed  that the predicted protein sequence is identical to GmNFR5 in two  positions that are crucial for Nod factor perception in other legumes.  Analysis of the AhNFP LysM2 tridimensional model revealed that these  two amino acids are very close, delimiting a zone of the molecule essential  for Nod factor recognition. These data, together with the analysis of the  molecular structure of Nod factors of native peanut symbionts previously  reported, suggest that peanut and soybean could share some of the  determinants involved in the signalling cascade that allows symbiosis  establishment.","palabras_clave":"Bradyrhizobia|Molecular recognition|Nod factor|Nod factor receptor proteins|Peanut|Symbiosis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18326,"idioma_id":4,"titulo":"Draft Genome Sequences of Pseudomonas fluorescens Strains SF39a and SF4c, Potential Plant Growth Promotion and Biocontrol Agents","resumen":"Pseudomonas fluorescens SF4c and SF39a, strains isolated from wheat rhizosphere, have potential applications in plant growth  promotion and biocontrol of fungal diseases of crop plants. We report the draft genome sequences of SF4c and SF39a with estimated  sizes of 6.5 Mb and 5.9 Mb, respectively","palabras_clave":"GENOME|SEQUENCES|PSEUDOMONAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18327,"idioma_id":4,"titulo":"Synthesis and characterization of Bi1-xNdxFeO3 (0 &#61603;x&#61603; 0.3) prepared by thermal decomposition of Bi1-xNdx[Fe(CN)6].4H2O","resumen":"The series of polycrystalline heteronuclear complexes, Bi1&#8722;xNdx[Fe(CN)6]·4H2O (0 &#8804; x &#8804; 0.3), was successfully synthesized and characterized, by means of powder X-ray diffraction (PXRD) and infrared spectroscopy. The thermal behaviour was studied by thermogravimetric and differential thermal analysis. The crystal structure of the complexes was refined by Rietveld analysis. It was found that they crystallized in the orthorhombic crystal system, space group Cmcm. The lattice parameters and unit cell volume decrease with an increase in Nd concentration. In order to obtain the oxides Bi1&#8722;xNdxFeO3, the thermal decomposition of the inorganic complexes, Bi1&#8722;xNdx[Fe(CN)6]·4H2O, has been investigated. By Rietveld analysis of PXRD data, the synthesis of the oxides was confirmed, evidencing in the series, a gradual change in crystal structure from rhombohedra to triclinic. Furthermore, with an increase in Nd content in Bi1&#8722;xNdxFeO3 oxides, impurity phases, such as Bi2O3, Bi2Fe4O9 and Bi25FeO39 associated with the synthesis of BiFeO3, are reduced. The morphology and chemical composition were investigated by microscopy electronic scattering and energy-dispersive X-ray spectroscopy. The electrical and magnetic properties have been determined to characterize the obtained oxides.","palabras_clave":"FERROELECTRIC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18328,"idioma_id":4,"titulo":"Crystal structure prediction from first principles: The crystal structures of glycine","resumen":"Here we present the results of our unbiased searches of glycine polymorphs obtained using the genetic algorithms search implemented in MGAC, modified genetic algorithm for crystals, coupled with the local optimization and energy evaluation provided by Quantum Espresso. We demonstrate that it is possible to predict the crystal structures of a biomedical molecule using solely first principles calculations. We were able to find all the ambient pressure stable glycine polymorphs, which are found in the same energetic ordering as observed experimentally and the agreement between the experimental and predicted structures is of such accuracy that the two are visually almost indistinguishable","palabras_clave":"Crystal structure predictions|Polymorphism|Glycine"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18329,"idioma_id":5,"titulo":"El humor como un recurso didáctico privilegiado en las prácticas de enseñanza de docentes universitarios memorables","resumen":"        En el presente  artículo nos dedicamos a profundizar una dimensión de la categoría 'resonancia  emocional', construida a partir de hallazgos obtenidos en nuestra investigación  en torno a las buenas prácticas de enseñanza de una profesora de la Facultad de Humanidades  de la Universidad   Nacional de Mar del Plata, Argentina. La docente integra el  grupo de 'profesores memorables' elegidos como ejemplos de buena enseñanza por  estudiantes avanzados. La mencionada  categoría fue construida a partir del peculiar enfoque de la enseñanza de la  profesora, quien prioriza la trama vincular afectiva con los estudiantes como  factor crucial para la comprensión de objetos complejos, como son los temas  filosóficos que aborda. Nos dedicamos aquí específicamente, a la inclusión del  humor en sus clases, puesto que es un recurso didáctico persistente en su  configuración didáctica. Se trata de una apelación al sentimiento de alegría,  que conforma un clima de clase distendido y propicio para la comprensión. A partir de 'registros etnográficos de clases', entrevista a la docente, encuestas a los  estudiantes, diario de campo, testimonios y materiales referenciales  construimos categorías que nos permiten avanzar en el conocimiento de la buena  enseñanza universitaria.   ","palabras_clave":"TRAMA VINCULAR AFECTIVA|ALEGRÍA|PROFESORES MEMORABLES|DIDÁCTICA DEL NIVEL SUPERIOR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18330,"idioma_id":4,"titulo":"Anatomical changes induced by Azospirillum brasilense in in vitro rooting of pink lapacho","resumen":"The pink lapacho Handroanthus impetiginosus, a South American native deciduous tree, is widely grown as an ornamental, medicinal, and timber resource. In vitro culturing allows ex situ conservation but may cause anatomical changes that decrease plant survival. This study evaluated the ability of Azospirillum brasilense to reverse such changes in H. impetiginosus in an in vitro culture under different conditions. H. impetiginosus shoots were induced with different indole-3-butyric acid (IBA) pulse treatments (3 days), transferred to two half-strength media (Murashige-Skoog salts with Gamborg´s vitamins [½MSG] and woody-plant medium [½WPM]), and were inoculated or not inoculated with A. brasilense Cd or Az39 strains. Rooted plant samples were processed for observation under light and scanning electron microscopy. Factorial analysis revealed significant triple interaction between medium type, IBA concentration, and bacteria inoculation (p &#8804; 0.01) for all anatomical parameters. A. brasilense Cd inoculation significantly increased (p &#8804; 0.05) mesophyll thickness in ½WPM for 10-50 &#956;M IBA inductions and in ½MSG for 0, 10, and 40 &#956;M IBA inductions compared to uninoculated plants. The Cd strain decreased stomatal density by 29% in plants grown in ½MSG compared to uninoculated plants, whereas the Az39 strain increased the same by 30%. Bacterial colonization improved periclinal epidermal cell division, bundle fiber development, secondary stem growth, and root hair density compared to that in uninoculated plants. The H. impetiginosus rooting by A. brasilense inoculation, mainly with the Cd strain, decreased undesirable anatomical modifications generated in vitro, enhancing adaptation to ex vitro conditions after transplanting.","palabras_clave":"ANATOMY|AZOSPIRILLUM BRASILENSE|BIGNONIACEAE|HANDROANTHUS IMPETIGINOSUS|IN VITRO ROOTING|PLANT GROWTH PROMOTING RHIZOBACTERIA."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18331,"idioma_id":4,"titulo":"Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans","resumen":"A rapid molecular-based assay for the detection of the Candida albicans FKS1 gene mutations responsible for resistance to echinocandindrugs was designed and evaluated. The assay consisted of a multiplexed PCR set of 5 tubes able to detect the most commonlydescribed resistance mechanism, including FKS1 hot spot 1 and hot spot 2 mutations. The performance and specificity ofthe assay was evaluated using a double-blinded panel of 50 C. albicans strains. The assay showed a sensitivity of 96% and wasable to detect all homozygous mutants included in the collection of strains, demonstrating that it is a robust, quick, and laborsavingmethod that is suitable for a routine clinical diagnostic laboratory.","palabras_clave":"Candida albicans|FKS1 Mutations|Echinocandin Resistance"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18332,"idioma_id":4,"titulo":"Post-flowering  photoperiod  and  radiation  interaction  in  soybean  yield determination: Direct and indirect photoperiodic effects","resumen":"Soybean (Glycine max (L.) Merrill) exposure to long days during the post-flowering phase increases total biomass, nodes, pods and seeds per plant, and also the post-flowering duration, increasing the radiation offer. This work aims to identify the main mechanisms responsible for yield increases in response to long days, separating direct photoperiodic effects on yield determination, from the indirect effect associated with changes in cumulative radiation when the crop cycle is modified by photoperiod. Two field experiments were conducted with an indeterminate soybean cultivar. A factorial combination of two radiation levels (unshaded and shaded), and two or three photoperiod regimes (control, extended 1.5 and 3h) was imposed from flowering to maturity. Yield tended to be reduced by shade and increased by extended photoperiod mainly through their effects on nodes per m2, and thereby affecting pods and seeds per m2. Photoperiod extension increased node number due to both increased cumulative radiation (indirect effect) and delayed reproductive development (direct effect). As a result, more pods were established per unit of cumulative radiation under extended photoperiod. The results suggest that photoperiod extension enhanced yield radiation use efficiency due to the alleviation of intra-nodal interferences. The direct post-flowering photoperiodic effect on node number and the resultant effects on pod and seed number, provide evidence of direct photoperiodic effects on soybean yield determination. © 2015 Elsevier B.V.","palabras_clave":"photoperiod|soybean|radiation|yield"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18333,"idioma_id":5,"titulo":"Efecto del haloperidol sobre el contraste sucesivo positivo consumatorio en ratas adultas con aislamiento adolescente","resumen":"Las ratas expuestas a aislamiento adolescente (AA) muestran alteraciones neurológicas y conductuales en la adultez, muchas de ellas relacionadas con cambios en la respuesta ante reforzadores apetitivos. En estudios previos las ratas con AA mostraron un incremento del Contraste Sucesivo Positivo consumatorio (CSPc, i.e, mayor consumo de una solución azucarada al 32%, 24 hs después de tener acceso a una solución al 4%), respecto de animales sin AA. El objetivo de este estudio fue evaluar si este efecto está asociado a la hiperactividad dopaminérgica. Se administró haloperidol a animales con AA (0.1 mg\/kg, i.p.) antes de los ensayos de incremento del refuerzo y salina a un grupo control. No se halló CSPc en los animales que recibieron haloperidol, mientras que en los sujetos con salina se observó en un ensayo. Si bien los resultados apoyan la hipótesis propuesta, es necesario realizar futuros experimentos para determinar con mayor precisión el correlato neuroquímico del incremento de CSPc en animales con AA.","palabras_clave":"AISLAMIENTO_ADOLESCENTE|CONTRASTE_POSITIVO|HALOPERIDOL|DOPAMINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18334,"idioma_id":4,"titulo":"DFT study of CO adsorption on Pd-SnO2(110) surfaces","resumen":"We studied the effect of Pd on the adsorption of CO on the tin oxide surface SnO2(110) by Density Functional Theory calculations. Molecular CO adsorbs more strongly in the presence of Pd pre-deposited on the surface. The most stable adsorption sites are those bonded to the Pd atom near a Pd top position on a tilted configuration. In this case the C-O distance increases, producing a bond weakening, and the calculated stretching frequency decreases. Analysis of the atomic orbital interactions reveals that Pd-CO bonding involves C s - O p  and  p orbitals from CO, with Pd d orbitals.  For CO sites bonded to Pd, CO bonds to the surface producing a weakening on the surface Pd-O bond.  The electronic configuration analysis shows that in all cases the CO molecule withdraws charge from the surface.","palabras_clave":"CO|PALLADIUM|DFT|SNO2"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18335,"idioma_id":4,"titulo":"Comparative In Vitro Study of Surface Treatment of Grade II Titanium Biomedical Implant","resumen":"Titanium is the gold standard material in oral implantology due to its convenient properties: biocompatibility, low density, high resistance, high rigidity, excellent bone attachment and biological stability. Many researchers have proved that it is possible to improve the implant fixation and to reduce osseointegation time through surface treatments, which lead to the development of an adequate topography. In this study, discs of commercially pure titanium, grade II were subjected to sand blasting using Al2O3 particles, acid etching using HF and HCl\/H2SO4 solutions and 600°C heat treatment during one hour. To determine in vitro behavior, samples were submerged in simulated body fluid. The obtained surface characterization was observed by scanning electron microscopy and electron probe microanalyzer. Results showed titanium as the only component of the treated surfaces, which proves acidic treatment effectiveness and an elevated decontamination; moreover, this treatment achieved a submicrometric topography that may influence on clot retention and bone matrix formation. Heat treatment samples showed a coating of crystalline agglomerations, whose elemental composition was calcium and phosphorus, apatitic kind, which follows the rough morphology of substrate.","palabras_clave":"TITANIUM|SAND BLASTING|OSSEOINTEGRATION|BI-ACIDIC TREATMENT|HEAT TREATMENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18336,"idioma_id":5,"titulo":"Africa al sur del Sahara:conflictos y degradación ambiental en el Sahel","resumen":"El Sahel es una región ubicada al sur del desierto del Sahara, donde se conjugan múltiples problemáticas: sequías, degradación de suelos, presión demográfica, desnutrición, pobreza, migraciones, conflictos, refugiados, entre otras. Los cambios ambientales provocan un fuerte impacto en las dimensiones socioculturales, políticas y económicas, actúan como multiplicadores de las tensiones sociales y estimulan la inestabilidad política.El objetivo de este artículo es identificar estas problemáticas y analizar las variables ambientales, con el fin de abordar el contexto territorial. La investigación se orientó hacia la interpretación de diversas fuentescomo cartografía, estadísticas y publicaciones académicas, que abren la posibilidad de mirar y comprender de manera integral la compleja trama de conflictos que perduran, así como los emergentes en este territoriotransfronterizo de África","palabras_clave":"AMBIENTE|CONFLICTOS|GEOGRAFÍA|SAHEL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18337,"idioma_id":4,"titulo":"Effects of urban green areas on air temperature in a medium sized Argentinian city","resumen":"Urban climate is the result of both atmospheric and geographic factors affecting a region, as well as the morphology, structures and human activities in a city. Urban vegetation in particular affects this climate at a local scale and provides many other social, economic and ecological benefits. Thus, it is important to explore the effects of different green areas used for urban and periurban agriculture and forestry activities (UPAF) on daily atmospheric temperature and the required degrees of cooling or refrigerating temperature. Comfort temperatures were defined using a range 18?24 °C and analyzed using actual measured as well as forecasted temperatures using a future scenario. Actual temperatures were recorded from September 2013 to August 2014 using digital sensors across eight sites in Rosario, Argentina: three in the central core with no vegetation, one in the central core with street trees, one in an urban agriculture site, one in a public park and two in periurban agricultural areas. Results show that air temperature in the central core with no vegetation were higher than those in other sites with vegetation during day and night, with the exception of the temperatures measured at the central core site with street trees. Findings also show that temperature effects in urban agricultural gardens of approximately 0.2 ha were similar to those of gardens and public parks 2&#8210;3 ha in size. Three UPAF types were classified according to cooling degree days, which decreased in order from (1) central core with no trees; (2) central core with street trees and public parks; and (3) urban and periurban agriculture areas. Conversely, the opposite trends for heating degree days were found. Results from this study can be used for integrating UPAF measures into climate change mitigation and urban planning policies in medium-sized cities in the developing world.","palabras_clave":"CLIMATE CHANGE|COOLING REQUIREMENTS|HEATING REQUIREMENTS|GREEN INFRASTRUCTURE|URBAN AGRICULTURE|URBAN FORESTRY|URBAN HEAT ISLAND"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18338,"idioma_id":4,"titulo":"First hepatitis B virus full-length genomic study among blood donors from Argentina: unexpected mutations in the circulating subgenotypes proteins.","resumen":"Hepatitis B virus (HBV) is a worldwide public health concern. The circulation of strains carrying mutations in the viral proteins implies both clinical and therapeutics challenges. HBV complete genomes (HBV-CGs) were reported from injecting drug users and HBV chronically infected patients from Argentina-including Amerindians-although no studies were conducted in blood donors. Here, we described HBV-CG sequences from the latter population. Some of the HBV sequences classified as B2 and C2 subgenotypes clustering together with Asian isolates, while others, such as D3, F1b, and F4, were homologous to European and Latin America sequences. New substitutions for all analyzed open reading frames and changes in the HBsAg hydrophobicity profiles were detected. Several HBV-CG subgenotypes are described for the first time in this population. Mutations observed in X, PreS, and P proteins have been associated with advanced liver disease, hepatocellular carcinoma, and\/or natural resistance to nucleos(t)ide antiviral treatment. It deserves to be highlighted that these substitutions were detected in a population without epidemiological risk factors for viral infection, and most importantly, without any previous antiviral treatment (natural resistance). Regarding the remaining mutations, further research is warranted in order to determine their clinical and therapeutics relevance.","palabras_clave":"Hepatitis B virus|Blood donors|Complete genomes|Subgenotypes, mutants"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18339,"idioma_id":4,"titulo":"Adrenal response in offspring male rats exposed to prenatal stress and to early postnatal stimulation","resumen":"Stress in pregnant rats alters the pattern of secretion of corticosterone (COR) and alters hypothalamic-pituitary-adrenal axis (HPA) function in offsprings. However, early postnatal handling could reverse the effects caused by increased secretion of COR. The aim of this work was to determine the effects of prenatal stress and postnatal handling on the activity of HPA axis in male rats and to elucidate the possible mechanism involved. After treatment, male Wistar rats 3 months old were divided into 4 groups: prenatally stressed without postnatal handling (PSNH), prenatally stressed with postnatal handling (PSH), non-prenatally stressed without postnatal handling (PCNH) and non-prenatally stressed with postnatal handling (PCH). Adrenal glands were collected from scarified adult rats, weighed to determine adrenosomatic index (relative size of glands compared to the rest of the animal´s body) and observe if there is any relation to COR level. Apoptosis process in adrenal cortex was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and detection of active caspase 3 expression. Our results show that adrenal gland cortex:medulla ratio was altered in prenatally stressed rats and also that treatment induced apoptosis (as per TUNEL and active caspase 3 expression) could be reverted by early offspring handling. In conclusion, postnatal handling can prevent some of the adverse effects of prenatal stress on representative parameters of adrenal gland cell death.","palabras_clave":"adrenal gland|apoptosis|early handling|hypothalamic-pituitary-adrenal axis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18340,"idioma_id":4,"titulo":"Rationale Behind an Optimal Field Experiment to Assess the Suitability of Soil Moisture Retrieval Algorithms for SAR Data","resumen":"Validation of soil moisture products derived fromsynthetic aperture radar (SAR) remotely sensed observations in-volves a comparison against ground-truth data. This validationstep helps one to state the performance of competing retrievalalgorithms. Nevertheless, the design of a field experiment in thecontext of SAR retrieval is not straightforward. Ground-basedmeasurements are affected by instrument errors due to both thephysical limitations of the measurement technique and the uncer-tainties related to the spatial variability of the soil moisture. Toproperly assess the performance of the retrieved estimates, both ofthe mentioned sources of uncertainties should be considered in theground-based sampling and in the subsequent error assessmentanalysis. This letter addresses the rationale behind an optimalfield experiment designed to assess the suitability of soil moistureretrieval algorithms.","palabras_clave":"Ground-based sampling|Remote sensing applications |Surface soil moisture|Synthetic Aperture Radar (SAR) estimates"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18341,"idioma_id":4,"titulo":"Differential local connectivity and neuroinflammation profiles in mPFC and hippocampus in the valproic acid rat model of autism","resumen":"Autism Spectrum Disorders (ASD) are a group of developmental disabilities characterized by impaired social interaction, communication deficit and repetitive and stereotyped behaviors. Neuroinflammation and synaptic alterations in several brain areas have been suggested to contribute to the physiopathology of ASD. Although the limbic system plays an important role in the functions found impaired in ASD, reports on these areas are scarce and results controversial. In the present study we searched in the medial prefrontal cortex (mPFC) and hippocampus of rats exposed to the valproic acid (VPA) model of ASD for early structural and molecular changes, coincident in time with the behavioral alterations. After confirming delayed growth and maturation in VPA rats, we were able to detect decreased exploratory activity and social interaction at an early time point (PND35). In mPFC, although typical cortical column organization was preserved in VPA animals, we found that interneuronal space was wider than in controls. Hippocampal CA3 pyramidal layer and the granular layer of the dentate gyrus both showed a disorganized spatial arrangement in VPA animals. Neuronal alterations were accompanied with increased tomato lectin and GFAP immunostainings both in mPFC and hippocampus. In the latter region, the increased GFAP immunoreactivity was CA3-specific. At the synaptic level, while mPFC from VPA animals showed increased synaptophysin (SYN) immunostaining, a SYN deficit was found in all hippocampal subfields. Additionally, both the mPFC and the hippocampus of VPA rats showed increased neuronal cell adhesion molecule (NCAM) immunostaining together with decreased levels of its polysialylated form (PSA-NCAM). Interestingly, these changes were more robust in the CA3 hippocampal subfield. Our results indicate that exploratory and social deficits correlate with region-dependent neuronal disorganization and reactive gliosis in mPFC and hippocampus of VPA rats. While microgliosis is spread in these two limbic areas, astrogliosis although extended in mPFC, is circumscribed to the CA3 hippocampal subfield. Our work indicates that neuroinflammation and synaptic alterations do coexist in VPA rats, making this model suitable for studying novel aspects of neuron-glia interactions. Moreover, it suggests that mPFC and hippocampus might behave differently in the context of the local hyperconnectivity and synaptic hypotheses of autism.","palabras_clave":"AUTISMO|HIPOCAMPO|CONECTIVIDAD SINAPTICA|NEUROINFLAMACION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18342,"idioma_id":4,"titulo":"'Inhibition of growth and metastasis of breast cancer in mice by milk fermented with Lactobacillus casei CRL431","resumen":"Breast cancer is the second cause of death in women, Who are especially related to uncontrolled metastasis. It was previously demonstrated that the administration of milk fermented by Lactobacillus casei CRL 431 [fermented milk (FM)] delayed the tumor growth in a murine breast cancer model. In this work we evaluated if the administration of FM to mice, starting when the tumor was measurable, can affect not only the tumor growth, but also the extravasation of tumor cells and the lung metastasis. The evaluation of immune cells?infiltrating tumors and lungs was also performed. Tumor volume was calculated. Whole blood, lungs, and liver were processed to count the number of colonies formed by tumor cells. Blood serum was obtained for monocyte chemoattractant protein-1, interleukin (IL)-10, and IL-6 determination, lung tissues for histologic observations, and tumor tissues for angiogenesis determination. Mice that received FM were compared with animals given milk or to the controls without any especial supplementation. The results showed that FM administration to mice decreased or suppressed tumor growth, with less tumor vascularity,extravasation of tumor cells, and lung metastasis. These benefits were associated to modulation of the immune response by decreasing the infiltration of macrophages in both the tumor and the lungs. FM administration maintained an increased antitumor response associated to CD8+ lymphocytes, and also increased CD4+ lymphocytes that can be involved in the modulation of the immune response. The future evaluation of cytokine profiles will allow knowing more about subpopulation of macrophages and lymphocytes associated to the beneficial effect of this probiotic in the breast cancer model.","palabras_clave":"PROBIOTIC|BREAST CANCER|IMMUNE RESPONSE|METASTASIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18343,"idioma_id":4,"titulo":"Effect of Sildenafil on Pre-Eclampsia-Like Mouse Model Induced By L-Name","resumen":"N(omega)-nitro-L-arginine methyl ester (L-NAME) decreasesthe vasodilator effect of nitric oxide (NO) and induces preeclampsiain mouse. Sildenafil inhibits the degradation ofnitric oxide and increases vasodilation. This study aimed todetermine the effects of sildenafil citrate on angiogenesis andoxidative stress at the maternal foetal interface on preeclampsia-like mouse model induced by L-NAME. Twentypregnant mice were divided into four groups: (i) vehiclecontrol; (ii) L-NAME; (iii) sildenafil; (4) L-NAME+sildenafil.L-NAME was administered from day 7 of pregnancy andsildenafil from day 8 until day 16; animals were euthanized onday 17. Placental and foetal sizes and weights were measured;lipid peroxide levels and catalase activity in placental homogenateswere determined, and placental vascular endotheliawere identified by lectin-histochemistry using BSA-I lectin.Western blot analysis was used to determine VEGF expressionin placental homogenates. No changes were seen in placentaland foetal development in mice with normal pregnanciestreated with sildenafil. Treatments with L-NAME reducedsignificantly the placental weight and average height anddecreased the percentage of the endothelial surface. Thesealterations may be mediated by the reduction of NO levels introphoblastic cells, due to the inhibitory effect of L-NAME onnitric oxide synthase (NOS) synthesis. This effect was offset bythe treatment with sildenafil, with an increase in the percentageof the endothelial surface. In conclusion, our results indicatethat treatment with sildenafil on pre-eclampsia mouse modelcan be used without adverse effects on the concept and its usein the treatment of pre-eclampsia is promising.","palabras_clave":"PREECLAMPSIA|SILDENAFIL|MOUSE MODEL|L-NAME|OXIDATIVE STRESS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18344,"idioma_id":4,"titulo":"Adhesion study in metal-ceramic systems of dental restoration by acoustic emission","resumen":"This study analyzes and quantifies the adhesion strength at interfaces between a metal and other ceramic materials. This is part of a larger work focused on the characterization of this type of interfaces applied in the area of dental materials. The experimental work consists in preparation, manufacturing and testing of specimens under IRAM-ISO 9693 Standard Project, related with porcelain-metal dental restoration systems. The Standard proposes assays involving the determination of the applied force causing the detachment or separation of a portion of ceramic deposited on a metal base, during a three-point bending test. Nowadays, there are no precise methods to assess with accuracy the instant of the debonding. It is a continuation of a previous work, using the Acoustic Emission (AE) method to determine more precisely the process of separation between the materials and also to assess the type of fracture process. This technique involves detection of signals produced by any source of AE such as propagation of microcracks, deformation, etc. These sources change the material stress field, producing and propagating elastic waves that reach the surface, where they are detected by the AE sensors.  In these tests, the bending load is applied at a constant rate on the metal substrate. A load cell senses the applied force. The AE is measured with a two-channel AE system, obtaining the features of the AE signals. Furthermore, a displacement sensor (LVDT) was implemented to correlate load with the tip displacement. The tests are monitored and filmed with a digital microscope.","palabras_clave":"ACOUSTIC EMISSION|METAL\/CERAMIC PAIRS|DENTAL MATERIALS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18345,"idioma_id":5,"titulo":"Estrategias de aprendizaje y motivación académica en estudiantes universitarios de Buenos Aires","resumen":"El presente trabajo examina las estrategias de aprendizaje y la motivación de 185 estudiantes universitarios de Buenos Aires, provenientes de diversas carreras universitarias (45.4% varones, 54.6% mujeres) con edades entre 19 y 33 años (M=21.88; DE=2.57).  Como grupo de comparación se empleó una muestra de185 educandos del nivel medio (41.3% varones, 58.7% mujeres), entre 13 y 20 años (M=15.60; DE=1.53). Se empleó una encuesta de datos sociodemográficos y académicos, el Inventario de Estrategias de Aprendizaje y Estudio  (Stover, Uriel & Fernández Liporace, 2012) y la Escala de Motivación Académica (Stover, de la Iglesia, Rial Boubeta & Fernández Liporace, 2012) en sus versiones adaptadas a población local. Se encontró un mayor uso de estrategias de aprendizaje y un perfil motivacional intrínseco en los alumnos de nivel universitario, en los que cursaban carreras de orientación Humanística y en quienes presentaban mejor desempeño académico. El examen de las relaciones entre motivación y las estrategias detectó que los tipos motivacionales intrínsecos se asociaban positivamente con el uso de estrategias, mientras que los extrínsecos covariaban con un menor uso. Estas conclusiones revisten interés para los profesionales que se desempeñan en instituciones educativas de cara al diseño de intervenciones didácticas adecuadas a las características halladas.","palabras_clave":"universitarios|motivación|estrategias de aprendizaje|rendimiento académico"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18346,"idioma_id":4,"titulo":"A CARBON NANOTUBE\/POLY [NI- (PROTOPORPHYRIN IX)] COMPOSITE FOR AMPEROMETRIC DETECTION OF LONG CHAIN ALIPHATIC AMINES.","resumen":"Poly [Ni-Protoporphyrin] film (pNiPP), containing multiwall carbon nanotubes (MWCNT) was used to cover aglassy carbon electrode. The hybrid material (pNiPP\/MWCNT) successfully combines the permselectivity ofpNiPP with the high conductivity of MWCNT.The modified electrode was used to perform amperometric detection of long chain aliphatic amines (LCAA) inorder to prevent the passivation effect of the aliphatic chain. Cyclic voltammetry (CV) and electrochemical impedancespectroscopy (EIS) demonstrated that the pNiPP\/MWCNT facilitates the electron transfer reaction.The charge transfer resistance (Rct) values were significantly lower by up to one order of magnitude comparedto the bare electrode. Differential pulse polarography (DPP) showed a marked decrease of the overpotential generatedby the aliphatic chain. The calibration of the amperometric peak area vs. concentrations of derivatizedLCAA exhibits a linear response within the range of 0.018 and 28 ìM and correlation coefficient (R2) higherthan 0.999 (n = 5). The quantitation limit of the pNiPP\/MWCNT electrode is about 400 times lower thanthe UV?visible detection. RSD of 7.2%, 5.8%, 2.5% and 2.3% was obtained for concentrations of 0.028, 0.28, 2.8and 28 ìM of ferrocenyl octadecylamine. A solution of sphingosine, 0.23 ìM, was exclusively detected withHPLC-ECD with pNiPP\/MWCNT electrode.","palabras_clave":"POLY [Ni-PROTOPORFHYRIN]|MWCNT|HYBRID MATERIAL|ALIPHATIC AMINES|AMPEROMETRIC DETECTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18347,"idioma_id":4,"titulo":"Existence, Uniqueness and Convergence of Simultaneous Distributed-Boundary Optimal Control Problems","resumen":"We consider a steady-state heat conduction problem $P$ for the  Poisson equation with mixed boundary conditions in a bounded  multidimensional domain $Omega$. We also consider a family of  problems $P_{alpha}$ for the same Poisson equation with mixed  boundary conditions being $alpha>0$ the heat transfer coefficient  defined on a portion $Gamma_{1}$ of the boundary. We formulate  simultaneous emph{distributed and Neumann boundary} optimal control  problems on the internal energy $g$ within $Omega$ and the heat  flux $q$, defined on the complementary portion $Gamma_{2}$ of the  boundary of  $Omega$ for quadratic cost functional. We prove  existence and uniqueness of the optimal control  $(overline{overline{g}},overline{overline{q}})$ for the system  state of $P$, and  $(overline{overline{g}}_{alpha},overline{overline{q}}_{alpha})$  for the system state of $P_{alpha}$, for each $alpha>0$, and we  give the corresponding optimality conditions. We prove strong  convergence, in suitable Sobolev spaces, of the optimal controls,  system and adjoint states governed by the problems $P_{alpha}$ to  the corresponding optimal control, system and adjoint states  governed by the problem $P$, when the parameter $alpha$ goes to  infinity. We also obtain estimations between the solutions of these  optimal control problems and the solution of two optimal control  problems characterized by fixed $g$ (with boundary optimal control  $overline{q}$) and fixed $q$ (with distributed optimal control  $overline{g}$), respectively, for both cases $alpha>0$ and  $alpha=infty$.","palabras_clave":"SIMULTANEOUS OPTIMAL CONTROL|MIXED ELLIPTIC PROBLEMS|OPTIMALITY CONDITION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18348,"idioma_id":5,"titulo":"Impacto del ejercicio prolongado en la albuminuria y estado inflamatorio en maratonistas con diabetes mellitus tipo 1","resumen":"El estrés oxidativo y mediadores inflamatorios son considerados probables factores causales del aumento de la excreción urinaria de albúmina (EUA) en pacientes con Diabetes Tipo 1 (DM1). El ejercicio también aumenta transitoriamente la EUA en DM1 y en no diabéticos. Se desconocen los mecanismos del aumento de EUA en ejercicios intensos y no está claro si administrar antioxidantes tendría algún efecto. Medimos en 12 maratonistas, 6 DM1 y 6 controles (C): 1) EUA, 2) Antioxidantes totales (TAS), 3) Proteína Quimioatractante de Monocitos (MCP-1) y 4) Proteína C-Reactiva Ultra-Sensible (HS-PCR) al inicio, final y 24h tras correr una 1ª media maratón 21 km (1ªmM) y lo mismo en una 2ªmM tras recibir Vitaminas E y C 1g\/dia, 7 días previos. Los datos se analizaron con ANOVA y pos-test de Bonferroni. Resultados: la EUA (mg\/g) basal fue normal en DM1 y C (5,66±1,2 vs 5,16±2,0 mg\/g). Post-1ªM aumentó la EUA en ambos grupos, mayor en DM1 (65,1±20,7 vs 20,0±2,4 mg\/g P<0,01). 24h post-1ªM los valores volvieron al valor basal. La suplementación con vitaminas no modificó el comportamiento de la EUA en la 2ªM. Los TAS (mM\/L) disminuyeron 24h post-1ªM en ambos grupos con mayor reducción en DM1 (0,6±0,1 vs 1,1±0,1; P<0.02). La ingesta de vitaminas mantuvo los TAS en los valores basales en la 2ªM (post-carrera y 24h). En la 1ªM HS-PCR, sin diferencias al inicio, aumentó 24h post-carrera en ambos pero más en DM1 (1,7±0,3 mg\/dL vs 5,5 mg\/dL±0,9) y MCP-1 aumentó post-inmediato en ambos (711 ±77pg\/mL vs 985 pg\/mL±107) sin retorno al valor basal a las 24h en DM1. No se observaron cambios en la 2ªM. Conclusiones: Una menor capacidad antioxidante y un aumento de MCP-1 y HS-PCR podrían estar implicados en la mayor EUA transitoria inducida por el ejercicio intenso y sostenido en DM1. La ingesta de vitaminas E y C mejora la reserva antioxidante total pero no modifica la EUA ni los marcadores inflamatorios estudiados","palabras_clave":"MICROALBUMINURIA|MARATON|ESTRES OXIDATIVO|DIABETES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18349,"idioma_id":4,"titulo":"Challenges and Opportunities for Implementation of Interventions to Prevent and Control CVD in Low-Resource Settings. A Report From CESCAS in Argentina.","resumen":"In Argentina, cardiovascular diseases cause an estimated 100,000 deaths and more than 250,000 coronary heart disease and stroke events annually, at a cost of more than $1 billion international dollars. Despite progress in the implementation of several programs to combat noncommunicable diseases in Argentina over the past few years, most health resources are still dedicated to infectious diseases and maternal and child health. The Institute for Clinical Effectiveness and Health Policy, an independent academic institution affiliated with the University of Buenos Aires medical school, runs the South American Centre of Excellence in Cardiovascular Health (CESCAS), a center devoted to epidemiology, implementation, and policy research. At the CESCAS, there are 3 ongoing randomized clinical trials focused on implementation science: 1) a mobile health intervention, for preventing the progression of prehypertension in low-income, urban settings in Argentina, Guatemala, and Peru; 2) a comprehensive approach to preventing and controlling hypertension in low-resource settings in Argentina; and 3) an educational approach to improving physicians´ effectiveness in the detection, treatment, and control of hypercholesterolemia and high cardiovascular disease risk in low-resource settings in Argentina. All of these trials involve the design and implementation of complex interventions for changing the behaviors of providers and patients. The rationale of each of the 3 studies, the design of the interventions, and the evaluation of processes and outcomes are described in this article, together with the barriers and enabling factors associated with implementation-research studies. There is a strong need in Argentina and all of Latin America for building the health-research capacity and infrastructure necessary for undertaking implementation studies that will translate evidence from research findings into improvements in health policy and practice with regard to cardiovascular diseases and their risk factors.","palabras_clave":"IMPLEMENTATION|INTERVENTION|PREVENTION|CARDIOVASCULAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18350,"idioma_id":5,"titulo":"Una herramienta digital en inglés para el aprendizaje disciplinar en español en la universidad","resumen":"El objetivo de esta investigación fue constatar la construcción de conocimientos disciplinares de los alumnos de las ingenierías de la UNLAM. A tal fin se construyó, se puso en uso y se evaluó una página Web con textos en inglés y guías de lectura en español. Esta investigación surgió de la necesidad de facilitar el acceso a conocimientos curriculares en inglés a alumnos universitarios hispano-parlantes. Las conceptualizaciones teóricas que fundamentaron el trabajo fueron: educación a distancia y aprendizaje virtual, lectura activa y procesos de comprensión, la teoría cognitiva y el aprendizaje significativo. La investigación fue de carácter descriptivo, exploratorio y experimental (I + D), y se esperaba que su conclusión reforzase la hipótesis de la relación estrecha entre la lectura en inglés y la adquisición de conocimientos específicos. El resultado satisfactorio de tres experiencias permitió la ampliación del uso del sitio mediante la inclusión de distintos textos y actividades con resolución escrita y oral para uno de los cuatro niveles de inglés Transversal. Según los nuevos resultados, el sitio se expandirá a los otros tres niveles para optimizar el aprendizaje del idioma extranjero en la universidad.","palabras_clave":"PAGINA WEB|INGLES|HISPANO-PARLANTES|CONOCIMIENTOS DISCIPLINARES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18351,"idioma_id":5,"titulo":"Perversión e inversión sexual en la psiquiatría argentina a principios del siglo XX","resumen":"RESUMEN. El artículo es producto de la investigación de la becaria Noelia Garcia Neira que explora los diversos autores que trataron el tema de la perversión entre principios del siglo XX y la década del cuarenta. Aborda teorías y abordajes de Jose Ingenieros, Angel Garma, etc.  Este artículo se presenta como parte integrante de una investigación  más amplia que lo determina y brinda soporte en sus desarrollos.  El objetivo en este caso será realizar un abordaje de las conceptualizaciones y material clínico en Argentina, durante principios del siglo XX, encontrados en autores como: Francisco De Veyga, Bernardo Etchepare, José Ingenieros y Víctor Mercante. Se procurará reflexionar sobre la receptividad de los diversos saberes internacionales en el campo específico de la psiquiatría en nuestro país, a los fines de rastrear el criterio clínico utilizado para definir a la homosexualidad femenina y sus conceptos asociados: perversión-inversión y sexualidad femenina, en este determinado contexto histórico.","palabras_clave":"HOMOSEXUALIDAD FEMENINA|CASUISTICA|PSIQUIATRÍA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18352,"idioma_id":4,"titulo":"The terpene ketones as natural insecticides against Sitophilus zeamais","resumen":"Eleven terpene ketones, thymoquinone, (R)-carvone, (S)-carvone, pulegone, dihydrocarvone, menthone, verbenone, ocimenone, camphor, &#61537;-thujone and piperitenone were tested as contact and fumigant insecticides against adults of Sitophilus zeamais Motschulsky under laboratory conditions. The results show that thymoquinone was found to be more toxic as compared with other ketones, with lethal doses values of  LD50 16.5 &#61549;g\/cm2 and LD50 13.8 &#61549;L\/L air (24h after treatment). The ketones were also subjected to multiple regression analysis. The results derived from QSAR model suggested that topological indices, Balaban and Randic index, are best descriptors of insecticidal activity of ketones. However orbital electronegativity of carbonyl group was the main parameter that connected the inhibition activity of ketones on AChE. Thus, the modeling of the insecticidal activity of terpene ketones is limited to shape of molecules and the branching of the carbon-atom skeleton, while inhibition of activity of AChE is limited to electronic descriptors.","palabras_clave":"TERPENE KETONES|INSECTICIDES|ACETYLCHOLINESTERASE|SITOPHILUS ZEAMAIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18353,"idioma_id":4,"titulo":"FORAGING LIVESTOCK MOVEMENT ON A PADDOCK DURING FIVE MONTHS GRAZING PERIOD","resumen":"The animals from extensive grazzing systems manifest a complex behavior, resulting from the incidence of different biotic and abiotic factors that determine their conduct. The distance that animals away from drinking water determines the distribution of cattle in the pasture and consequently the effects produced on vegetation. With the aim to describe the movement of breeding cows on sandy grassland paddock, georeferenced locations of 4 randomly selected adults cows were recorded every 15 minutes between September 2012 and January 2013. The animals, with stocking rate adjusted to forage production, grazed extensively 150 days on a rectangular paddock of 750 ha, with only watering point located in the middle of one of its smaller sides. Animal behavior was described for two half periods, by the distance that the animals away (linearly) from the watering point. The 4 cows that carried GPS data logger showed a similar pattern, remaining on average 46% of the days of the first half at distances less than 2000 m. By contrast, during the second half (from December, with higher temperatures) were concentrated near the water only few days, and most days (59%) travel to distant areas (> 2500 m), without returning to drink approximately one third of the days in question. Foraging behavior, in addition to help from paddocks sizing, can be helpful to define different strategies for livestock management (e.g. animals rotation).","palabras_clave":"movimiento animal|distancia recorrida|GPS logger"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18354,"idioma_id":4,"titulo":"NEW IMMUNIZATION PROTOCOL TO PRODUCE CROTALIC ANTIVENOM COMBINING CROTALUS DURISSUS TERRIFICUS VENOM AND ITS PLA2","resumen":"Antivenoms are usually obtained by animal immunization with successive inoculations of increasing sublethal amounts of venom, which may impair the animal health. The high lethality of venom requires prolonged immunization plans with small amounts of venom. Thus, we propose an alternative plan that includes a pre-immunization of the animal with phospholipase A2, the main crotoxin component, which is responsible for the whole venom lethality. For comparison, three different immunization schemes were designed: high dose protocol (HDP; 0.5?27 mg of venom), low dose protocol (LDP; 0.1?7 mg of venom) and Mix protocol (MP; preimmunization 0.1?1.2 mg of crotalic PLA2, and then 4.5?8 mg of venom). Antibody titers were determined by ELISA, in blood plasma obtained from the marginal vein of the ear. The neutralizing ability of the different sera obtained by all protocols (HDS, LDS and MS) was tested against the most important pharmacological activities of whole venom: PLA2 activity, myotoxicity, thrombin like activity and lethality. MS showed the best neutralizing efficacy and at the same time, it was obtained by an immunization protocol that takes account of animal health care, since it requires low quantities of venoms in comparison to traditional protocols.","palabras_clave":"Crotalic envenomation|Phospholipase A2|Animal health care"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18355,"idioma_id":5,"titulo":"Estabilidad de color de resinas para prótesis provisional","resumen":"El objetivo de este estudio fue evaluar la estabilidad del color de dos materiales utilizados para la confección de prótesis provisionales compuestos a base de resina polimetil metacrilicato y de resina bisacrilica al ser sometidos a la inmersión de tres sustancias pigmentantes: café, bebida cola y vino tinto. Se utilizaron 90 discos de resina polimetilmetacrilato (duralay) y resina bisacrilica. Las unidades experimentales fueron medidas antes y después de de la inmersión primero en agua destilada y luego en las diferentes soluciones en estufa a 37° durante 24 hs. Las mediciones de color fueron evaluadas usando un colorímetro Kónica Minolta CR-400. El análisis estadístico se utilizó el test de Tukey (ANOVA) en un nivel de significación  de 0.05 Resultados: los materiales evaluados presentaron diferencia de color siendo la mayor diferencia al ser sumergido en vino tinto. Conclusiones: Las resinas y las bebidas son factores importantes que pueden afectar la estabilidad de color. Después de la inmersión por  24 hs todos los materiales mostraron cambios de color, siendo los mas significativos a la inmersión en vino tinto","palabras_clave":"RESINA POLIMETILMETCRILATO|RESINA BISACRILICA|COLOR|BIOMATERIALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18356,"idioma_id":4,"titulo":"Dynamic rheological analysis of gluten-free pasta as affected by composition and cooking time","resumen":"The present work analyzes the effect of cooking times and dough composition on the rheological properties of gluten-free pasta. Gluten-free pasta dough was prepared with corn starch, corn flour, NaCl, dry egg and dry egg-white powders, sunflower oil, xanthan and locust bean gums. Small amplitude oscillatory data was used to obtain the relaxation spectrum. For all the formulations assayed G0 was always greater than G00 in the frequency range measured and the increase of both moduli with frequency was small.Oscillatory spectra were satisfactorily predicted using the Maxwell Generalized model. Cooking time had a stronger effect on the mechanical spectra than protein and water contents. Hydrothermal treatment produced a significant microstructural change within the network entanglements. The analysis of the rheological behavior showed that water uptake by the matrix, partial gelatinization of the starch, and aggregation of denatured egg proteins led to chemical and morphological changes of the cooked pasta.","palabras_clave":"GLUTEN-FREE PASTA|COOKING TIME|RHEOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18357,"idioma_id":4,"titulo":"A stochastic fire spread model for north Patagonia based on fire occurrence maps","resumen":"Understanding fire spread in different ecosystems is of fundamental importance for conservation, management and anticipating the effects of environmental changes. Tailoring existing fire spread models to particular landscapes is challenging because it demands a substantial data collection effort. Here we develop an objective way to fit simple stochastic fire spread models based on readily available data from documented fire events (i.e. approximate ignition point, preexisting vegetation, final perimeter, topography, and average wind direction). We use a simulation-based approach founded on Approximate Bayesian Computation, which allows for a thorough exploration of parameter space as well as the quantification of uncertainty around best estimates. As illustration, we use data from nine fire events that occurred during dry years in northern Patagonia, Argentina. We found that fire spreads readily in shrublands, while forests tend to act as firebreaks. Topography has a strong effect not only because fire moves easily upslope but also because it modulates wind direction. Finally, aspect affects fire spread mainly in forests, probably due to its effects on fuel moisture. Simulating fire spread sampling parameters from the approximated joint posterior distribution resulted in individual fires roughly similar to the ones used for model fitting. Furthermore, the fitted model was able to produce simulated fire-size distributions in good agreement with the historical record for dry years in Nahuel Huapi National Park, Patagonia. The approach presented here can be used in places where standard fuel models have not yet been developed.","palabras_clave":"STOCHASTIC FIRE SPREAD|APPROXIMATE BAYESIAN COMPUTATION|FIRE|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18359,"idioma_id":4,"titulo":"UPQC implemented with Cascade Asymmetric Multilevel Converters","resumen":"The power quality (PQ) in distribution systems is affected by the  pollution introduced by the customers. The Unified Power Quality Controller  (UPQC) custom power device is the most integral actuator to improve the quality  of the systems. Today, several manufacturers offer solutions using multilevel  inverters in medium voltage applications with different control methods. In  particular, the Cascaded Asymmetric Multilevel Converter (CAMC) is a novel  alternative among the 5-level converters for back-to-back application. In this  paper an UPQC with two CAMC in back-to-back connection is proposed. The hybrid  modulation technique used in the CAMC made easier the implementation of the  control objectives. Those are, regulating the voltage on sensitive load and  control of its reactive power and harmonics current. They are carried out  managing the active and reactive power into the UPQC. The model and the control  strategy are discussed in d-q coordinates and the performance of the  proposed UPQC is evaluated with SPICE simulations.","palabras_clave":"Power Quality"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18360,"idioma_id":4,"titulo":"E2F1 and E2F2 induction in response to DNA damage preserves genomic stability in neuronal cells","resumen":"E2F transcription factors regulate a wide range of biological processes, including the cellular response to DNA  damage. In the present study, we examined whether E2F family members are transcriptionally induced following  treatment with several genotoxic agents, and have a role on the cell DNA damage response. We show a novel  15 mechanism, conserved among diverse species, in which E2F1 and E2F2, the latter specifically in neuronal cells, are  transcriptionally induced after DNA damage. This upregulation leads to increased E2F1 and E2F2 protein levels as a  consequence of de novo protein synthesis. Ectopic expression of these E2Fs in neuronal cells reduces the level of DNA  damage following genotoxic treatment, while ablation of E2F1 and E2F2 leads to the accumulation of DNA lesions and  increased apoptotic response. Cell viability and DNA repair capability in response to DNA damage induction are also  20 reduced by the E2F1 and E2F2 deficiencies. Finally, E2F1 and E2F2 accumulate at sites of oxidative and UV-induced DNA  damage, and interact with gH2AX DNA repair factor. As previously reported for E2F1, E2F2 promotes Rad51 foci  formation, interacts with GCN5 acetyltransferase and induces histone acetylation following genotoxic insult. The results  presented here unveil a new mechanism involving E2F1 and E2F2 in the maintenance of genomic stability in response  to DNA damage in neuronal cells.","palabras_clave":"DNA DAMAGE RSPONSE|GENOMIC STABILITY|DNA REPAIR|E2F TRANSCRIPTION|NEURONAL CELLS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18361,"idioma_id":4,"titulo":"Tractable Probabilistic mu-Calculus That Expresses Probabilistic Temporal Logics","resumen":"We   revisit a recently introduced probabilistic mu-calculus and study an   expressive fragment of it. By using the probabilistic quantification as   an atomic operation of the calculus we establish a connection between   the calculus and obligation games. The calculus we consider is strong   enough to encode well-known logics such as pctl and pctl^*. Its game   semantics is very similar to the game semantics of the classical   mu-calculus (using parity obligation games instead of parity games).  This leads to an optimal complexity of NPcap co-NP for its finite model   checking procedure. Furthermore, we investigate a (relatively)   well-behaved fragment of this calculus: an extension of pctl with fixed   points. An important feature of this extended version of pctl is that   its model checking is only exponential w.r.t. the alternation depth of  fixed points, one of the main characteristics of Kozen´s mu-calculus.","palabras_clave":"MU-CALCULUS|PROBABILISTIC LOGICS|MODEL CHECKING|GAME SEMANTICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18362,"idioma_id":4,"titulo":"Assessing refactorings for usability in e-commerce applications","resumen":"Refactoring has been reported as a helpful technique to systematically improve non-functional attributes of software. This paper evaluates the relevance of refactoring for improving usability on web applications. We conducted an experiment with two replications at different locations, with subjects of different profiles. Objects chosen for the experiment were two e-commerce applications that exhibit common business processes in today?s web usage. Through the experiment we found that half of the studied refactorings cause a significant improvement in usability. The rest of the refactorings required a post-hoc analysis in which we considered aspects like user expertise in the interaction with web applications or type of application. We conclude that, when improving quality in use, the success of the refactoring process depends on several factors, including the type of software system, context and users. We have analyzed all these aspects, which developers must consider for a better decision support at the time of prioritizing improvements and outweighing effort.","palabras_clave":"Usability|Refactoring|E-commerce"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18363,"idioma_id":4,"titulo":"Non-Native Vegetation Induces Changes in Predation Pressure and Escape Behavior of  Two Sand Lizards (Liolaemidae: Liolaemus)","resumen":"          Abstract: The  introduction of exotic plant species may generate habitat modifications that in  turn increase the predation risk for preys, either by making them more  conspicuous, by offering perches to predators or by limiting suitable refuges.  We compared predation pressure and escape behavior of two sympatric lizard  species (Liolaemus wiegmannii and L. multimaculatus) inhabiting forested  and nonforested grasslands of the pampasic coastal sand dunes of Buenos Aires  province, Argentina. Predation pressure was estimated by measuring the  abundance of avian predators and calculating the predation rate on lizard  plasticine replicas. Escape behavior was studied by searching for lizards in  the field. Once a lizard was sighted we recorded flight initiation distance (FID)  between the observer and the lizard before it started escaping and the type of microhabitat  used as refuge. Both lizard species prefer refuges in native plants, but when  they are scarce Acacia longifolia &nbsp;was the alternative refuge. In forested  habitats sand-burying behavior is a complementary strategy used by L. multimaculatus. FID of L. wiegmannii was greater in forested  habitats than in nonforested ones, confirming the assumptions of theoretical  models of escape behavior. By contrast, L.  multimaculatus showed a short FID in forested habitats, mostly because  sand-burying behavior allows this species to hide ??beneath their feet??  reducing risks typically associated with exposed areas. Plasticity in  antipredatory behavior suggests that these lizards could learn to recognize  predators and develop a suitable antipredatory behavior. We conclude that  increased predation pressure and structural alterations of the habitat  generated by exotic trees of A.  longifolia affect the decisions that determine how, when and where these  lizards flee.  ","palabras_clave":"Flight initiation distance|Habitat alteration|Acacia|Detection"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18364,"idioma_id":4,"titulo":"Multiple paternity in a wild population of the corn mouse: its potential adaptive significance for females","resumen":"      Mating with multiple males within a single  reproductive event is a common female mating strategy in mice and voles, but  its adaptive function is often unclear. In this study, we used 7 microsatellite  loci to investigate if multiple paternity occurs in wild populations of the  socially promiscuous Calomys musculinus.  We also analyzed if multiple paternity increases litter size and\/or genetic variability  among offspring. In addition, we examined if multiple paternity occurs more  frequently in litters conceived at high population density, than those  conceived at low population density. By genotyping 23 females and their 135  embryos (5.9 ± 1.6 S.E. pups per female) we found that 56.5% of the litters  were sired by two or three males. We found no association between multiple  paternity,&nbsp; litter size &nbsp;and genetic variability. In addition, multiple  paternity did not vary in relation to population density. Our results provide clear evidence  of multiple paternity, and offers the first genetic documentation of mating systems in  mice in our country. We discuss the extent of multiple paternity in relation to potential adaptive strategies in female corn  mouse.  ","palabras_clave":"CALOMYS MUSCULINUS|MULTIPLE PATERNITY|MATING SYSTEMS|MULTI-MALE MATING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18365,"idioma_id":4,"titulo":"Protoceratium reticulatum (Dinophyceae) in the austral Southwestern Atlantic and the first report on YTX-production in shelf waters of Argentina","resumen":"Protoceratium reticulatum is a dinoflagellate with a life cycle that includes a motile planktonic stage and a resting cyst stage of benthic habitat, both with a wide geographical distribution, including southern South America. P. reticulatum produces yessotoxins (YTXs) which are accumulated in shellfish, show potent cytotoxicity and pose a danger to human health via consumption of contaminated seafood. YTXs have been reported from coastal shellfish of many localities, but until now it was unknown if they were present at the austral Southwestern Atlantic and also if local populations of P. reticulatum have the ability to produce these toxins. In this study we report the presence of YTXs in plankton samples and its production in culture by two P. reticulatum strains isolated from the San Jorge Gulf (SJG). In addition, we describe the geographical distribution and seasonal abundance of this species based on data collected over the past two decades. The YTX cell quotas calculated from net hauls (~10 pg cell?1) are in the same range as the toxin cell quotas observed in these two isolates. The phylogenetic analysis of sequences of the hypervariable region of the large subunit (LSU) 28S rDNA showed that the two clonal strains from the SJG were part of a monophyletic clade that subdivides P. reticulatum into two well supported, divergent sub-clades. The sequences of the two strains of P. reticulatum from the SJG fell in the same clade as the majority of sequences of P. reticulatum, which belong to a geographically wide distributed evolutionary clade. P. reticulatum was occasionally observed from about 35°S in Uruguayan shelf waters up to 53°S in the Patagonian shelf and north of Tierra del Fuego, and it was present from coastal areas up to the shelf break zone. We recorded P. reticulatum in plankton samples from spring to autumn, throughout the warmer period of the year, and invariably in low abundance (maximum: 560 cells L?1). Viable cysts of the species in surface sediments also showed a wide geographical distribution, which, together with high total abundances and high relative numerical contribution to planktonic dinoflagellate assemblages near frontal areas, emphasize the necessity to pay attention to the dynamics of this species in areas of potential risk of harmful algal bloom development.","palabras_clave":"DINOFLAGELLATES|SOUTHWESTERN ATLANTIC|PHILOGENY|YESSOTOXINS|CYSTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18366,"idioma_id":4,"titulo":"Rainwater harvesting in the Dry Chaco: evolving strategies and challenges","resumen":"Rainwater harvesting (RWH) has been essential for the establishment of human settlementsin many dry regions of the world that lacked suitable surface or ground water resources. A vast fraction of the South American Dry Chaco ecoregion still relies on RWH to support, not only livestock production, but domestic and industrial uses as well. As a result, water capture and storage infrastructure is widely disseminated throughout the region. In this paper we characterized the most typical RWH systems in two contrastingly developed sub-regions of Dry Chaco ranging from extensive ranching to intensive beef and dairy production (central Argentina and western Paraguay, respectively). In each sub-region, we quantified RWH density, spatial distribution and associations with landscape features; by other hand, we illustrated how the daily dynamic of water stock in a typical RWH system contributes to assess their capture and storage efficiency. We found that randomly distributed, low-tech RWH systems prevail in central Argentina, while clustered and hi-tech systems do it in western Paraguay. Their density was highly contrasting between sub-regions (0.098 vs. 0.94 units\/ km2 in central Argentina and western Paraguay, respectively), being exponentially associated with land cleared fraction and proximity to villages. The daily monitoring of water level suggested a positive but complex response of water capture to precipitation. The elongated catchment area, created by roads and trails, could have partially decoupled local precipitation and water yield of the impoundment, favouring the capture of remote precipitation events and generating highly variable water yield under large local precipitation events. Once stored, the rates of water level decline suggested that infiltration exceeded evaporation as a water output pathway (59 vs. 41%, respectively, of total losses). Across both study areas, RWH accounts for less than 1% of the annual precipitation, playing a minor role on the regional water balance; however at a local level, they can affect several hydrological fluxes including the onset of groundwater recharge and the mitigation of extreme runoff events along roads and trails.&nbsp;","palabras_clave":"RWH|impoundments|catchments|runoff|evaporation|infiltration|dry lands"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18367,"idioma_id":4,"titulo":"Evidence of cellular senescence during the development of estrogen-induced pituitary tumors","resumen":"Although pituitary adenomas represent 25% of intracranial tumors, they are usually benign, with the mechanisms by which these tumors usually avoid an invasive profile and metastatic growth development still remaining unclear. In this context, cellular senescence might constitute a plausible explanation for the benign nature of pituitary adenomas. In the present study, we investigated the emergence of cellular senescence as a growth control mechanism during the progression of estrogen-induced pituitary tumors. The quantification of Ki67-immunopositive cells in pituitaries from estrogenized male rats after 10, 20, 40 and 60 days revealed that the mitogenic potential rate was not sustained for the whole period analyzed and successively decreased after 10 days of estrogen exposition. In addition, the expression of cellular senescence features, such as the progressive rise in the enzymatic SA-b-galactosidase activity, IL6, IL1b and TGFb expression was observed throughout pituitary tumor development. Furthermore, tumoral pituitary cells also displayed nuclear pATM expression, indicating activated DNA damage signaling, with a significant increase in p21 expression also being detected. The associations among DNA damage signaling activation, SA-b-galactosidase expression and p21 may provide a reliable Combination of senescence-associated markers for in vivo pituitary senescence detection. These results suggest a role for this cellular process in the regulation of pituitary cell growth. Thus, cellular senescence should be conceived as a contributing component to the benign nature of pituitary Adenomas, thereby influencing the capability of the pituitary gland to avoid unregulated cell proliferation.","palabras_clave":"pituitary |cellular senescence|estrogen |tumor"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18368,"idioma_id":4,"titulo":"'Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast'","resumen":"Abstract: In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction, and endocytosis activity  of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly  related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast cells, which is due to the higher endocytic activity of tumor cells compared to normal cells. In this way, we demonstrate that biosynthesized Ag NPs can be an alternative for the treatment of tumors.","palabras_clave":"Apoptosis, |Biosynthesized silver nanoparticles|Breast cancer|Microbiological synthesis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18369,"idioma_id":4,"titulo":"Dendroecological potential of shrubs for reconstructing fire history at landscape scale in Mediterranean-type climate grasslands: the case of Fabiana imbricata","resumen":"Fire recurrently affects Mediterranean-type climate (MTC) regions causing major  implications on the structure and dynamics of vegetation. In these regions, it is important to know the fire regime for which reliable fire records are needed. Dendroecology offers the possibility of obtaining fire occurrence data from woody species and has been widely used in forest ecosystems for fire research. Grasslands are regions with no trees where shrubs can provide dendroecological evidence for reconstructing fire history at landscape scale. We studied the dendroecological potential of the shrub F. imbricata to reconstruct fire history at landscape scale in MTC grasslands of northwestern Patagonia. In order to accomplish this, we combined spatio-temporal information of recorded fires  from the study area with the age structure of F. imbricata shrublands obtained from dendroecological methods. Shrubland age structure correctly described how often fires occurred in the past. In rocky outcrops, where fires cannot reach, individuals are long-lived and heterogeneous in age; while downhill, individuals are young and shrublands are even-aged. Five pulses of massive recruitment  were found: three of these coincided with three known fires; the remaining two had not been recorded before. A bi-variated analysis showed that F. imbricata recruited mainly during two years after fire, and the spatial distribution of pulses coincided with the fire map. Information derived from shrubland age  structure could be used to estimate fire regime parameters such as fire return interval at landscape or community scale. For instance, we estimated a fire return interval of nine years at landscape scale and ranging from 11-24 years at community scale (shrubland). Our results in northwestern Patagonia grasslands showed that the F. imbricata chronology can be used to complement other information sources such as remote sensing and operational databases improving the knowledge about fire regime. The present study demonstrates that is possible to utilize shrubs as a dendroecological data source to study fire history in regions where tree cover is absent.","palabras_clave":"SHRUBLAND AGE STRUCTURE|FIRE OCURRENCE|DENDROECOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18370,"idioma_id":4,"titulo":"Fire temperature effects on perennial grasses from northwestern Patagonian grasslands","resumen":"Post-fire recovery of perennial plants depends on their capacity to regrow from surviving meristems. Plants are adapted to a particular fire regime, which can be altered by human activities and climatic change. Therefore, predicting the impact of changing fire regimes on post-fire vegetation recovery has become a major ecological concern. We studied the  effects of fire temperature on survival and growth of the dominant tussock grasses Festuca pallescens and Pappostipa speciosa for two post-fire growing seasons in NW Patagonian grasslands. Using a portable propane burner, we applied two fire temperature treatments to individual plants: 200-500ºC (low temperature) and 500-900ºC (high temperature). Plant mortality was higher in F. pallescens than in P. speciosa, possibly due to morphological differences. Fire damaged active meristems in both species, which delayed emergence of new tillers. This in turn affected leaf length of tillers, which was lower in burned plants during the first growing season. Despite this, growth rate was higher in burned plants once they regrow only during the first growing season. In summer, post-fire hot and dry conditions affected F. pallescens survival. Although fire temperature affected negatively F. pallescens survival, both tussock grasses recovered quickly after the experimental burns. This response could favour their persistence and dominance in the community. Our study  increases understanding of post-fire responses in grasslands and will provide important rangeland management information for grasslands in Patagonia.","palabras_clave":"CLIMATE CHANGE|FIRE INTENSITY|FIRE REGIME|TUSSOCK GRASSES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18371,"idioma_id":4,"titulo":"Anti-inflammatory, Antioxidant and Antimicrobial Activity  Characterization and Toxicity Studies of Flowers of ?Jarilla?, a Medicinal Shrub from Argentina","resumen":"Zuccagnia &nbsp;punctata Cav. (Fabaceae) is  an Argentine medicinal aromatic shrub (jarilla pispito, puspus, lata and  jarilla macho). The chalcones were identified as pigments responsible for the  yellow color of the flowers. Hydroethanolic extracts were obtained both from fresh  flowers and from flowers dried by lyophilization. &nbsp;The extracts were standardized by their  phenolic and flavonoids content. Their fingerprints by HPLC-DAD indicated the  presence of two chalcones as major compounds (2?,4?-dihydroxychalcone and 2?,4?-dihydroxy-3?-methoxychalcone). Both extracts showed the same total phenolic, non-flavonoid phenolic and  flavonoid phenolic content and their phenolic profiles were similar. The polyphenolic extracts exhibited  antioxidant (free radical scavenging and inhibitory activity on  lipoperoxidation) and anti-inflammatory (inhibition of lipoxygenase and  cyclooxygenase enzymes) activities. The flower extracts were active against six Candida species with MIC values between  30 and 120 µg GAE.mL-1 and were also active on methicillin-resistant Staphylococcus aureus (MIC: 250 µg  GAE.mL-1) and Enterococcus  faecalis (MIC: 500 µg GAE.mL-1). The extracts were neither toxic  (Artemia salina test) nor mutagenic  (Ames test). Jarilla flowers could be  considered as a new dietary supplement that could help to prevent pathologies  associated with oxidative stress and the polyphenolic extract obtained from  them could be considered as a standardized phytotherapeutic product with antimicrobial,  antioxidant and anti-inflammatory activities.","palabras_clave":"Zuccagnia punctata,  |Flowers, Bioactive chalcones|Functional food, |Phytotherapeutic product,"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18372,"idioma_id":4,"titulo":"EVALUATION OF THE HAEMOCOMPATIBILITY OF TiO2 COATINGS OBTAINED BY ANODIC OXIDATION OF Ti-6Al-4V","resumen":"The blood compatibility (haemocompatibility) is a requirement in materials used in prosthetic heart valves. No standardized  methods are available to measure haemocompatibility in solid materials. However, a material could be considered  haemocompatible if its surface does not modify the normal activation of the coagulation pathway and produces no damage in the  blood components. In this work, the haemocompatibility of coatings obtained by anodic oxidation of Ti-6Al-4V (with H2SO4 1M  and 40 to 70 V) with and without heat treatment (1h for 500ºC), is evaluated and compared with the haemocompatibility of the  Ti-6Al-4V substrate and pyrolytic carbon. Standard clinical trials for clothing: Prothrombin Time (PT) and Activated Partial  Thromboplastin Time (APTT) were adapted to evaluate the haemocompatibility of solid materials. Besides, the interaction  between blood platelets and solid material were performed through an analysis of interfacial tension (&#947;i,j), this parameter could  indicate the degree of preferential adsorption of each protein of the blood plasma. The ratio between albumin-material and  fibrinogen-material interfacial tension, (&#947;s,Alb\/ &#947;s,Fib), is an important parameter used to predict the platelets adhesion and the trend  at the formation of cloth. The results of the clothing trials indicate that the tested surfaces would be haemocompatibles due to the  values of PT and APTT obtained which were in range of the normal ones. In addition, the measured values of &#947;s,Alb\/ &#947;s,Fib indicate  that all the tested surfaces are more haemocompatible than pyrolitic carbon. The recrystalized films by heat treatment which  produce some rutile crystals are the most haemocompatibles.","palabras_clave":"hemocompatibilidad|dioxido de titanio|oxidacion anodica|Ti grado 5"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18373,"idioma_id":4,"titulo":"TiO2 COATINGS IN ALKALINE ELECTROLYTES USING ANODIC OXIDATION TECHNIQUE","resumen":"For the construction of a new design of mechanical heart valve a Ti-6Al-4V alloy was selected and coated with TiO2 due to it corrosion resistance and biocompatibility. A required feature on surfaces in contact with blood it is a low level of roughness (Ra &#8804; 50 nm) that not favor the formation of blood clots. One technique that can be used to obtain smooth coatings of TiO2 is theelectrochemical anodic oxidation technique using pre-spark oxidation voltage. The phenomenon of spark produces porous oxides and roughness higher than desired. The beginning of the spark voltage depends on the electrolyte used. The present work compares the coatings obtained by anodic oxidation of the Ti-6Al-4V alloy applying different voltages (from 10V to 50V), usingas electrolyte an aqueous based alkaline solutions of NaOH and KOH, at different concentrations (0.1M, 1M and 2M) and Ca(OH)2 at a concentration of 0.02 M, using a constant current of 50mA to achieve the desired voltage. Morphological analysis of the different oxides is performed using optical microscopy, and roughness measurements using a profilometer. The phases present were analyzed by X-ray diffraction technique with a glancing angle of 1º. By varying the applied voltage coatings of different interference colors were obtained. The morphology and roughness of the obtained oxides varied according to the applied voltage in each experience. With KOH and NaOH 1M the spark occurred at 46V and 41V, respectively. The start voltage of the spark decreased to 34V and 29V, respectively, when the electrolyte concentration increase from 1M to 2M. In pre-spark conditions oxides were of an average roughness of 22 nm. After the spark, the oxides became with roughness of 700 nm, limiting the oxidation conditions for the desired application. Anatase and rutile phases were not detected in the coatings, which would be amorphous or with crystalline fractions undetectable by XRD.","palabras_clave":"Titanium|TiO2|Alkaline Electrolytes|Ti-6Al-4V"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18374,"idioma_id":4,"titulo":"ANODIC BEHAVIOR OF ALLOY 22 IN BICARBONATE MEDIA: EFFECT OF ALLOYING","resumen":"The alloy 22 (UNS N06022) is one of the candidates for the manufacture of containers of radioactive waste high level. These containers provide services in natural environments characterized by multi-ionic solutions, it is estimated they could suffer three types of deterioration: general corrosion, localized corrosion (specifically crevice) and stress corrosion cracking (SCC). It has been confirmed to produce cracking, requires the presence of bicarbonate and chloride ions. It has also determined that susceptibility to SCC could be related to the occurrence of an anodic peak in the polarization curves in these media to at potentials previous transpassive zone. The aim of this work is to study the anodic behavior of alloy 22 and its alloying effect in different media containing bicarbonate and chloride ions in different concentrations and temperatures.Polarization curves were made of alloy 22 (Ni-22% Cr-13% Mo), Ni-Mo (Ni-28, 5% Mo) and Ni-Cr (Ni-20% Cr) under the following conditions: 1 mol\/L NaCl at 90 °C, and 1.148 mol\/L NaHCO3, 1.148 mol\/L NaHCO3 + 1 mol\/L NaCl, 1.148 mol\/L NaHCO3 + 0.1 mol\/L NaCl at 90 °C, 75 °C, 60 °C and 25 °C.It was found that the alloy 22 has a current peak in the anodic at potential previous to transpassive zone, only when the medium has bicarbonate ions. Curves performed in 1 mol\/L NaCl did not show any anodic peak, in any of the alloys tested. The curves made to alloys Ni-Mo and Ni-Cr in the media with bicarbonate ions, allowed to determine that Cr, is responsible for the appearance of the anodic peak in the Alloy 22. The curves of alloy B-3 showed no current peak in the conditions studied. The potential, at which the peak appears in the Alloy 22 and Ni-Cr alloy, increases with decreasing temperature. It also presents a variation of the peak with the composition of the solution. When the chloride ion is added to bicarbonate solution, the peak is shifted potential and higher current densities, depending on the concentration of added chloride ions.","palabras_clave":"NICKEL BASED ALLOY|UNS N06022|BICARBONATE|ANODIC BEHAVIOR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18375,"idioma_id":4,"titulo":"INVESTIGATION ON AL2O3-REINFORCED ZINC-ALUMINUM MATRIX COMPOSITES","resumen":"Composite materials obtained by adding particles to the metallic matrix (MMCs) have made remarkable progress in its  development and applications in automotive and aerospace industries in recent decades. Among them the most current  application is MMCs with zinc and aluminum matrix. The present work is focused on the study of the effect of the directional  heat extraction on the alumina distribution inside the zinc-aluminum matrix and on the columnar ? to ? equiaxed (CET)  phenomenon in samples directionally solidified. The ZA-27 alloy was reinforced with ceramic-particulates of alumina (Al2O3)  and then vertically directionally solidified. The following parameters were measured: cooling rates, temperature gradients,  interphase velocities. And the influence of heat transfer on the solidification microstructure of the MMCs was analyzed.  Experimental results include transient metal\/mould heat transfer coefficients, secondary dendrite arm spacings and particle  distribution as a function of solidification conditions imposed by the metal\/mould system. The results about the conditions for the  CET in MMCs are compared with those obtained in directional solidification of Zn-Al alloys.","palabras_clave":"metal matrix composites|alumina reinforcement|solidification|microstructure"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18376,"idioma_id":4,"titulo":"Assessment of the pollen diet in a wood-dwelling augochlorine bee (Halictidae) using different approaches","resumen":"Most studies on bee pollen diet are based on the abundance of each pollen type composing honey or pollen stores of whole nests (pollen counts). In an effort to characterize the diet of the augochlorine bee Augochlora amphitrite, we employed nest and intra-nest pollen analyses and bee flower visitation. In addition, we tested a novel approach, the Index of Relative Importance (IRI), a method that combines pollen counts, pollen volume and frequency of pollen occurrence. Using nest pollen analysis we found that the Ludwigia type dominated pollen counts, comprising 56% of whole nests, and thus would have concluded that this is the only most important pollen source in the diet. Instead we found seven other important sources including Ipomoea alba, I. cairica, Gymnocoronis spilanthoides and Pavonia types as well as 26 new floral hosts using all four methods in combination. Thus, we recommend that other studies of bee diet include these other approaches when possible, and especially the novel approach of IRI.                                                                                                   ","palabras_clave":"Augochlora amphitrite |floral visitation|index of relative importance (IRI)|intra-nest pollen analysis|Ludwigia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18377,"idioma_id":5,"titulo":"El financiamiento de las Pymes del sector de Software y Servicios Informáticos en Argentina","resumen":".","palabras_clave":"PEQUEÑAS EMPRESAS DE BASE TECNOLÓGICA (PEBTS), |FINANCIAMIENTO DE PYMES|ESTRUCTURA FINANCIERA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18378,"idioma_id":4,"titulo":"Pollen host selection by a broadly polylectic halictid bee in relation to resource availability","resumen":"The relationship between utilized and available resources in the same environment has not yet been studied in most wild bees. In a riparian forest, a total of 15 pollen types from 10 plant families were identified from pollen provisions of 17 nests of the wood-dwelling Augochlora amphitrite (Hymenoptera: Halictidae) for which only floral records have been known. During the foraging period, only five out of 108 available flowering species were visited intensively (more than 10 %) for pollen. As more than three families and 32.2 % of the available plant families were visited for pollen, the broad polylecty category was inferred. Like in other Augochlora species, a variety of floral types was visited by A. amphitrite, in agreement with its broadly polylectic foraging habit. The selection index was positive for the highly abundant Ludwigia (Onagraceae) and the rare Gymnocoronis spilanthoides (Asteraceae). The intensive foraging on Ludwigia could indicate temporary specialization for this abundant pollen resource. The tendency of this bee to visitintensively one flower type for pollen suggests that bee individuals had to learn to handle this abundant flower type. Pollen analysis complemented with field observations on floral resource availability proved to be helpful tools to provide information on the foraging behaviour of a wild bee in its natural environment.","palabras_clave":"AUGOCHLORA AMPHITRITE|HALICTIDAE|NEST PROVISION|POLLEN ANALYSIS|WILD BEE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18379,"idioma_id":4,"titulo":"Soil respiration in Patagonian semiarid grasslands under contrasting environmental and use conditions","resumen":"Grasslands comprise 85% of Southern Patagonia land area and play a critical role in the global carbon cycle. We evaluated seasonal dynamics to identify differences in soil respiration rates between contrasting grasslands across a climate gradient (rainfall), long term grazing intensity (moderate and high stocking rates) and land uses (silvopastoral system, primary forest and grassland). Soil respiration varied from 0.09 g CO2 h1 m2 in winter to a maximum of 1.43 g CO2 h1 m2 in spring. We found that the soil respiration rate was 30% higher in moderately grazed grasslands than in heavily grazed grasslands. Land use changes showed that soil respiration followed the order silvopastoral system &gt; nativeforest &gt; grassland. While almost all plant and soil variables had a significant effect on soil respiration, soil carbon concentration, litter cover and depth and bare soil cover were the main factors explaining 78 e83% of the variance in soil respiration. Soil respiration rates were correlated strongly to air and soil temperatures and to a lesser extent with mean monthly rainfall and soil volumetric water content. The information provided in the present work about soil respiration is essential to estimate carbon balance for a range of important and widespread ecosystems in Patagonia.","palabras_clave":"Grazing|Steppe|Soil moisture|Temperature"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18380,"idioma_id":5,"titulo":"BARRERAS A LA ACCESIBILIDAD PARA LA ATENCION ODONTOLOGICA EN PARAJES DE LA REGION DEL IBERA","resumen":"EL PRESENTE TRABAJO DESCRIBE LOS RESULTADOS PARCIALES DE LA RELACIÓN ENTRE EL USUARIOS Y SERVICIOS.EN CUANTO A COBERTURA, ACCESIBILIDAD Y DISPONIBILIDAD A LA ATENCIÓN DE SALUD BUCAL, DE LAS FAMILIAS HABITANTES DE LA REGIÓN DE LOS ESTEROS DEL IBERA.LAS VARIABLES ANALIZADAS SON DIMENSIONES EN LA INVESTIGACIÓN DEL COMPONENTE BUCAL DE LA SALUD DEL HOMBRE DEL IBERAEL OBJETIVO ES DESCRIBIR LA RELACIÓN FUNCIONAL ENTRE LA POBLACIÓN, PROFESIONALES, EQUIPAMIENTO E INSUMOS, MANIFESTADA YA SEA EN OBSTÁCULOS, IMPEDIMENTOS Y DIFICULTADES, O BIEN, FACTORES FACILITA DORES PARA LAS FAMILIAS QUE DEMANDAN ATENCIÓN ODONTOLÓGICA DE TAL MANERA DE POSIBILITAR A LAS POBLACIONES DE ZONAS RURALES, UN ACCESO EQUITATIVO A LOS SERVICIOS DE SALUD","palabras_clave":"DISPONIBILIDAD|NECESIDAD SALUD|ACEPTABILIDAD|CONTINUIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18381,"idioma_id":4,"titulo":"What type of teachers do we intend to train? An analysis of teacher profiles in MERCOSUR curricula","resumen":"Se presentó un análisis comparado de los perfiles de formación docente que están en el curriculum de la formación docente inicial, de los países del MERCOSUR","palabras_clave":"Formación Docente|Curricula|Capacidades docentes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18382,"idioma_id":5,"titulo":"Los insectos galícolas en Schinus fasciculata (Anacardiaceae) en el Espinal del centro de Argentina","resumen":"La más compleja de las interacciones que plantas e insectos han desarrollado durante el transcurso de su evolución, son las agallas.   Las especies de insectos galícolas se encuentran en la mayoría de las regiones biogeográficas, principalmente en ambientes xéricos, de los cuales un ejemplo lo constituye la ecorregión del Espinal, ubicada en la Provincia Biogeográfica de la Pampa, Subregión Chaqueña. Schinus fasciculata (Griseb.) I.M. Johnst. (Anacardiaceae) es una especie arbórea o arbustiva representativa de la ecorregión del Espinal que presenta diversas agallas entomógenas. Los objetivos del presente trabajo son identificar las especies de insectos que producen agallas en hojas y tallos de Schinus fasciculata en un relicto de Espinal de la provincia de Córdoba y caracterizar exomorfológicamente las agallas. Se seleccionaron 18 ejemplares de S. fasciculata distribuidos en cuatro transectas de 100 m2. Se caracterizaron cinco morfotipos de agallas, tres en hojas, inducidas por insectos del orden Hemiptera y dos en tallos, originadas por insectos del orden Lepidoptera. Los insectos productores de las mismas fueron identificados a nivel de especie y los   distintos morfotipos de agallas, fueron únicos para cada especie de insecto inductor.","palabras_clave":"CÓRDOBA|AGALLAS ENTOMÓGENAS|HEMIPTERA|LEPIDOPTERA|SUBREGIÓN CHAQUEÑA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18383,"idioma_id":4,"titulo":"Synthesis and characterization of HDTMA-organoclays: some insights into their structural properties","resumen":"This study aims to synthesize and characterize organoclays developed from an Argentinian montmorillonite (Bent) usinghexadecyltrimethylammonium bromide (HDTMA-Br) as the intercalation agent. Subsequently, an adsorption mechanism is proposed.The obtained organoclays were more hydrophobic than the starting clay. Surfactant molecules were adsorbed initially through cationexchange in sites placed in the interlayer space of the clay. Adsorption in such sites continued until the interlayer space was saturated.Depending on the surfactant loading introduced during the intercalation process, different organizations of surfactant in the interlayerwere obtained. Further adsorption of surfactant occurred in the mesopores generated by tactoids in the ?house of cards? organization.This process kept surfactant molecules relatively free and out of the interlayer space.","palabras_clave":"NANOCLAY|SURFACTANT|ADSORPTION|CATION-EXCHANGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18384,"idioma_id":4,"titulo":"Improving the physical properties of starch using a new kind of water dispersible nano-hybrid reinforcement","resumen":"Plasticized cassava starch matrix composites reinforced by a multi-wall carbon nanotube (MWCNT)?hercynite (FeAl2O4) nanomaterial were developed. The hybrid nanomaterial consists of FeAl2O4 nanoparticles anchored strongly to the surface of the MWCNT. This nano-hybrid filler shows  an irregular geometry, which provides a strong mechanical interlocking with the matrix, and excellent stability in water, ensuring a good dispersion in the starch matrix. The composite containing 0.04 wt.% of the nano-hybrid filler displays increments of 370% in the Young?s modulus, 138% in tensile strength and 350% in tensile toughness and a 70% decrease in water vapor permeability relative to the matrix material.All of these significant improvements are explained in terms of the nano-hybrid filler homogenous dispersion and its high affinity with both plasticizers, glycerol and water, which induces crystallization without deterioration of the tensile toughness.","palabras_clave":"CASSAVA STARCH  |HYBRID NANOMATERIAL|POLYMER NANOCOMPOSITE |CARBON NANOTUBES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18385,"idioma_id":4,"titulo":"Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood","resumen":"Food intake and body weight regulation depend on proper expressionof the proopiomelanocortin gene (Pomc) in a group of neuronslocated in the mediobasal hypothalamus of all vertebrates. Theseneurons release POMC-encoded melanocortins, which are potent anorexigenicneuropeptides, and their absence from mice or humansleads to hyperphagia and severe obesity. Although the pathophysiologyof hypothalamic POMC neurons is well understood, the geneticprogram that establishes the neuronal melanocortinergic phenotypeand maintains a fully functional neuronal POMC phenotype throughoutadulthood remains unknown. Here, we report that the earlyexpression of the LIM-homeodomain transcription factor Islet 1 (ISL1)in the developing hypothalamus promotes the terminal differentiationof melanocortinergic neurons and is essential for hypothalamic Pomcexpression since its initial onset and throughout the entire lifetime.Wedetected ISL1 in the prospective hypothalamus just before the onset ofPomc expression and, from then on, Pomc and Isl1 coexpress. ISL1binds in vitro and in vivo to critical homeodomain binding DNA motifspresent in the neuronal Pomc enhancers nPE1 and nPE2, and mutationsof these sites completely disrupt the ability of these enhancers todrive reporter gene expression to hypothalamic POMC neurons intransgenicmice and zebrafish. ISL1 is necessary for hypothalamic Pomcexpression during mouse and zebrafish embryogenesis. Furthermore,conditional Isl1 inactivation from POMC neurons impairs Pomc expression,leading to hyperphagia and obesity. Our results demonstrate thatISL1 specifies the identity of hypothalamic melanocortin neurons andis required for melanocortin-induced satiety and normal adipositythroughout the entire lifespan.","palabras_clave":"HYPOTHALAMUS|MELANOCORTIN|OBESITY|ISL1"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18386,"idioma_id":5,"titulo":"Contenido de nutrientes de bebidas artesanales a base de almendras","resumen":"Introducción y Objetivos: La comercialización de bebidas a base de almendras fortificadas con calcio (Ca), se ha difundido internacionalmente. Por su aspecto blanquecino se denominan usualmente ?leches?, siendo utilizadas en reemplazo de leche vacuna, sobre todo por vegetarianos estrictos. En Argentina se preparan solo de manera artesanal y se desconoce su contenido en nutrientes, en particular minerales. El objetivo del presente trabajo fue estudiar la composición centesimal y contenido de minerales de bebidas artesanales en base a almendras, utilizando distintas condiciones de obtención usualmente empleadas. Materiales y Métodos: Se elaboraron 4 bebidas utilizando 100g de almendras en 600ml de agua, variando tiempos de remojo (0-36hs) y con\/sin filtración. Se estudió Ca por espectrometría de absorción atómica, sodio (Na) y potasio (K) por espectrometría de emisión, previa mineralización nitro-perclórica (50:50). En almendras se determinaron los inositoles fosfatos (IP) por HPLC y se calculó la relación molar ácido fítico (AF)\/Ca, utilizando factores de conversión, como indicador de la disponibilidad potencial de Ca. Resultados: La composición de almendras fue (g%): grasas 53,5; proteínas 16,8; fibra dietaria total 9,6; cenizas 2,9; carbohidratos digeribles 12,0; minerales (mg%): Ca 221; K 555 y Na 0,7; IP (mg%): IP3 54, IP4 151, IP5 853, IP6 4838. La relación molar AF\/Ca resultó 1,6, muy superior a la recomendada (<0,17). En bebidas los resultados fueron (g%): grasas 3,2-5,6; proteínas 2,3-2,8; cenizas 0,2-0,3; minerales (mg%): Ca 9-18; K 56-68 y Na 13-16. Conclusiones: No se evidenciaron diferencias en nutrientes al comparar los diversos tiempos de remojo, ni con o sin filtración, resultando productos de muy bajo contenido de Na y Ca y moderado aporte de K.","palabras_clave":"ALMENDRAS|BEBIDAS|VEGETARIANISMO|CALCIO|POTASIO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18387,"idioma_id":4,"titulo":"Stochastic Path Perturbation Approach Applied to Non Local Non Linear Equations in Population Dynamics","resumen":"We described the first passage time distribution associated to the stochastic evolution from an unstable uniform state to a patterned one (attractor of the system), when the time evolution is given by an integro-differential equation describing a population model. In order to obtain analytical results we used the Stochastic Path Perturbation Approach introducing a minimum coupling approximation into the nonlinear dynamics, and a stochastic multiscale perturbation expansion. We  show that the stochastic multiscale perturbation is a necessary tool to handle other problems like: nonlinear instabilities and multiplicative stochastic partial differential equations. A small noise parameter  was introduced to define the random escape of the stochastic field. We carried out Monte Carlo simulations in a non-local Fisher like equation, to show the agreement with our theoretical predictions","palabras_clave":"non?linear population dynamics|non?local logistic models & Fisher equation|Random escape times, first passage time distribution|First passage time distribution"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18388,"idioma_id":4,"titulo":"Invasive conifers reduce seed set of a native Andean cedar through heterospecific pollination competition","resumen":"The invasion of natural forest communities by introduced woody species may threat processes that are critical for ecosystem integrity, including plant pollination and reproduction. In particular, invasive conifers (e.g., Pseudotsuga menziesii, Pinus spp.) escaped from forest plantations may impair seed production of anemophilous native conifers by altering the dynamics of wind-borne pollen flow among trees. In this study, we analyzed the effects of invasive conifers on the pollination and sexual reproduction of Andean cedar (Austrocedrus chilensis), a dioecious conifer native to the temperate forests of southern South America. Wind-dispersed pollen captured in pollen traps revealed that the timing of pollen release between the invasive and native conifers overlapped extensively, and the pollen cloud surrounding female cedar trees in invaded forest was heavily contaminated with pollen from the invasive conifers. Increasing abundance of invasive conifers in the proximity of female cedars decreased the local density of air-borne cedar pollen and increased contamination of the pollen cloud with pollen from the invasive conifers. This increased the chance of finding heterospecific pollen from these invaders in the micropyles of the native cedar. In turn, the presence of pollen grains from invasive conifers, particularly of P. menziesii, in the cedar?s micropyles was associated with a strong increase in the percentage of seed abortion. Our results clearly support the hypothesis that invasive conifers can interfere with the pollination and sexual reproduction of native wind-pollinated conifers. Thus, plantations of introduced and highly invasive conifers should not occur in the proximity of stands of native conifers in order to guarantee their reproduction and long-term population viability.","palabras_clave":"Austrocedrus chilensis |Pseudotsuga menziesii |Pinus |Anemophilous pollination |Exotic conifer invasion |Pollination interference| Seed production"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18389,"idioma_id":6,"titulo":"L?imaginaire social ou individuel, sa place dans la construction du sens. Le cas de la lecture de textes de spécialité en francais et en anglais langue étrangère.","resumen":"Résumé  Dans ce travail nous nous proposons de présenter les résultats préliminaires d?une enquête réalisée aux étudiants de Français et Anglais avant de commencer les cours pour essayer de connaître quelles sont les représentations culturelles qu?ils ont au moment d?entamer l?apprentissage de la lecture en langue étrangère, car nous considérons que les stéréotypes que l?étudiant possède sur le ou les pays où ces langues sont parlées représentent un  moteur ou  un frein pour la construction du sens. À partir d?un corpus composé de l?imaginaire social et individuel venant des réponses des étudiants, nous nous proposons d?identifier les images que les étudiants ont sur la culture des principales pays francophones et anglophones (France, Angleterre, Canada, États Unis, Australie), on veut aussi essayer de déterminer si la découverte de cet imaginaire permet ou ne permet pas de faire évoluer les représentations et les images sur la langue et la culture étrangères étudiées.","palabras_clave":"Langue|imaginaire social-individuel|références culturelles|culture"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18390,"idioma_id":4,"titulo":"Further data on sesamoid identity from two anuran species","resumen":"Considering that the identification of equivalent entities is the basis  for any comparative analysis, we compare the histology, histochemistry,  shape and dimensions of epiphyses, carpal and sesamoids in two anuran  frogs. Our goal was to explore the morphological correspondence among  these three skeletal elements in order to clarify the sesamoid identity. We  studied  the  skeletogenesis,  contour  geometric  morphometry  and  dimensions of forelimb elements of juveniles of two anurans species Leptodactylus bufonius and Rhinella arenarum. Skeletogenesis in anurans present a  common trait between carpals and sesamoids: both elements exhibit endochondral ossification. A difference between these elements is the presence  of  fibrocartilage  in  the  development  of  sesamoids.  The  geometric  morphometry does not allow us to establish a shape pattern that can be com-  pared either between sesamoids and epiphyses or carpals. With regard to  dimensions,  our  data  indicate  that  bones  categorization  based  on  these  aspects is ambiguous and therefore is useless to classify of skeletal bones.  The data about tissue differentiation of sesamoids provide evidence that  support the idea that these elements should be considered part of the typical endowment of the vertebrate skeleton.","palabras_clave":"histochemistry|frog| histology| forelimb"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18391,"idioma_id":5,"titulo":"Revistas de poesía: descripción de un objeto","resumen":"Análisis de las revistas de poesía como objeto de análisis teórico.","palabras_clave":"revistas|objeto|poesía|literatura"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18392,"idioma_id":4,"titulo":"Transcriptome analysis of seed development in apomictic Paspalum notatum","resumen":"The seed developmental process involves various tissues with several ploidy levelsand different genetic origins. Therefore, its characterization at the transcriptomelevel is certainly a challenge. The hypothesis of endosperm balance number (EBN)postulates that each species has an effective number that is important for normalendosperm and seed development to occur. Understanding endosperm formation inapomictic plants is crucial for the perspective of transferring apomixis to sexualspecies of agronomic interest. Since sexual tetraploid Paspalum plants fit the EBNpremise, the EBN insensitivity observed in apomictic plants might be a requirementfor the spread of pseudogamous apomixis. Crosses using several cytotypes of P.notatum were made in order to induce the development of seeds with differentcombinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.combinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.notatum were made in order to induce the development of seeds with differentcombinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.combinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.premise, the EBN insensitivity observed in apomictic plants might be a requirementfor the spread of pseudogamous apomixis. Crosses using several cytotypes of P.notatum were made in order to induce the development of seeds with differentcombinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.combinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.notatum were made in order to induce the development of seeds with differentcombinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.combinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.Paspalum plants fit the EBNpremise, the EBN insensitivity observed in apomictic plants might be a requirementfor the spread of pseudogamous apomixis. Crosses using several cytotypes of P.notatum were made in order to induce the development of seeds with differentcombinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.combinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.notatum were made in order to induce the development of seeds with differentcombinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.combinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.P.notatum were made in order to induce the development of seeds with differentcombinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.combinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.were made in order to induce the development of seeds with differentcombinations of maternal\/paternal genomic ratios in the endosperm. Atranscriptome characterization of ovaries 3 h after pollination was performed usingcDNA-AFLP methodology. Fourty-six of the 100 differentially expressed transcriptderivedfragments (TDFs) were specifically found in crosses in which apomicticplants were used as the female parent and presented a predicted m:p ratio in theendosperm that was different to the 2:1 requirement of the EBN. Moreover, 13 of theTDFs presented identity with proteins that were differentially expressed in responseto changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspensioncultures. eATP is an important molecular switch in plants that tightly controlsorganellar energy metabolism and activates gene expression controlling specificgrowth and developmental programs. The results suggest that eATP-mediatedsignaling could be involved in the regulation of endosperm development.","palabras_clave":"ENDOSPERM|ENDOSPERM BALANCE NUMBER|EXTRACELLULAR ATP|PASPALUM NOTATUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18393,"idioma_id":4,"titulo":"Immune neuroendocrine phenotypes in Coturnix coturnix: do avian species show LEWIS\/FISCHER-like profiles?","resumen":"          Immunoneuroendocrinology studies have identified conserved  communicational paths in birds and mammals, e.g. the  Hypothalamus-Pituitary-Adrenal axis with anti-inflammatory activity mediated by  glucocorticoids. Immune neuroendocrine phenotypes (INPs) have been proposed for  mammals implying the categorization of a population in subgroups underlying  divergent immune-neuroendocrine interactions. These phenotypes were studied in  the context of the LEWIS\/FISCHER paradigm (rats expressing high or low  pro-inflammatory profiles, respectively). Although avian species have some  common immunological mechanisms with mammals, they have also evolved some  distinct strategies and, until now, it has not been studied whether birds may  also share with mammals similar INPs. Based on corticosterone levels we  determined the existence of two divergent groups in Coturnix coturnix that also differed in other immune-neuroendocrine  responses. Quail with lowest corticosterone showed higher lymphoproliferative  and antibody responses, interferon-&#947; and interleukin-1&#946; mRNA expression levels  and lower frequencies of leukocyte subpopulations distribution and  interleukin-13 levels, than their higher corticosterone counterparts. Results  suggest the existence of INPs in birds, comparable to mammalian LEWIS\/FISCHER  profiles, where basal corticosterone also underlies responses of comparable  variables associated to the phenotypes. Concluding, INP may not be a mammalian  distinct feature, leading to discuss whether these profiles represent a  parallel phenomenon evolved in birds and mammals, or a common feature inherited  from a reptilian ancestor millions of years ago.  ","palabras_clave":"immnunology|Japanese quail|physiology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18394,"idioma_id":4,"titulo":"Kinetic characterization of human thyroperoxidase. Normal and pathological enzyme expression in Baculovirus System: A molecular model of functional expression","resumen":"Background: Human thyroperoxidase (hTPO) is amembrane-bound glycoprotein located at the apical membrane of the thyroidfollicular cells which catalyzes iodide oxidation and organification in thethyroglobulin (TG) tyrosine residues, leading to the thyroid hormone synthesisby coupling of iodotyrosine residues. Mutations in hTPO gene are the main causeof iodine organification defects (IOD) in infants. Methods: We investigated the functional impact ofhTPO gene missense mutations previously identified in our laboratory (p.C808R,p.G387R and p.P499L). In order to obtain the whole wild-type (WT) coding sequenceof hTPO, sequential cloning strategy in pGEMT vector was carried out. Then,site-directed mutagenesis was performed.WT and mutant hTPOs were cloned intothe pAcGP67B transfer vector and the recombinant proteins were expressed inBaculovirus System, purified and characterized by SDS?PAGE and Western blot.Moreover, we report for the first time the kinetic constants of hTPO, of bothWT and mutant enzymes.Results: The functional evaluation of therecombinant hTPOs showed decreased activity in the three mutants with respectto WT. Regarding to the affinity for the substrate, the mutants showed higherKm values with respect to the WT. Additionally, the three mutants showed lowerreaction efficiencies (Vmax\/Km) with respect to WT hTPO.Conclusions: We optimize the expression and purificationof recombinant hTPOs using the Baculovirus System and we report for the firsttime the kinetic characterization of hTPOs.","palabras_clave":"Human Peroxidase|Iodide Organification Defects|Expression|Baculovirus System|Kinetic characterization|Thyroperoxidase gene"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18395,"idioma_id":4,"titulo":"Neonatal hyperthyroidism on rat heart: interrelation with nitric oxide and sex.","resumen":"AbstractPURPOSE:To clarify the mechanism mediating the effect of hyperthyroidism on cardiac function during the second month of life in rats.METHODS:Male and female Sprague-Dawley rats were assigned to a control or to a triiodothyronine (T3)-treated group. Treatment of each group was started on the third day after birth. Control rats (Eut) received 0.9 NaCl [0.1 ml\/100 g body weight (BW)] every second day during 60 days and T3-treated rats (Hyper) received subcutaneous (SC) T3 injections every second day during 60 days.RESULTS:Hyperthyroidism decreased left ventricle volume only in male rats. Female euthyroid rats presented higher atrial nitric oxide synthase (NOS) activity than male rats and hormonal treatment decreased this enzyme´s activity in both sexes. Euthyroid male and female rats had similar atrial NOS protein levels, but females had higher caveolin (cav) 3 protein levels. T3 treatment increased this protein only in males. Female rats had lower ventricular NOS activity than male rats; hyperthyroidism increased NOS activity in both sexes but this effect was associated with lower cav 3 protein levels. Hyperthyroidism did not change cav 1 protein levels in both male and female rats.CONCLUSIONS:The results of this study demonstrating clinically relevant sex-related differences in the pathophysiology of the hyperthyroid heart have raised new questions regarding the mechanisms responsible for the observed differences. This study suggests that sex-related intrinsic factors such as nitric oxide may modulate the response to hyperthyroidism that leads to cardiovascular dysfunction.","palabras_clave":"HYPERTYROIDISM|HEART|NEONATAL|RAT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18396,"idioma_id":4,"titulo":"The reproduction of Colletia hystrix and late-flowering in Colletia (Rhamnaceae: Colletieae","resumen":"          Plant fitness strongly depends on the  timing of&nbsp; flower production. In temperate climates  most plants bloom during a relatively well-defined peak,  while comparatively few species flower before or after the  community peak. Since a phylogenetical signal has been  shown to exist in the determination of reproductive phenology, it  is of interest to identify characters associated with the  emergence of either type of behaviour. Here we report on the reproduction of the late-flowering shrub Colletia hystrix  and discuss the results in the context of the whole genus  Colletia. Colletia hystrix shares with its congeners deep  flowers, associated with assemblages of long-mouthpart  pollinators, and characters that maximise the chances of  successful pollen receipt and export in a single pollinator  visit (homogamy, a large stigma, and an extragynoecial  compitum). Leaflessness and extreme spinescence of Colletia are  suggested to be related (via compromised resource  acquisition) to phenological displacement and its flower-level  correlates.    ","palabras_clave":"COLLETIA HYSTRIX |BREEDING SYSTEM|POLLINATION EXPERIMENTS|REPRODUCTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18397,"idioma_id":5,"titulo":"'Estudio de las Competencias Socio Emocionales y su Relación con el Afrontamiento en Futuros Profesores de Nivel Medio'.","resumen":"Profundizar en el estudio de los aspectos psicosociales referidos a las competencias socioemocionales y considerar las relaciones existentes con el afrontamiento, en tanto recursos para afrontar la adversidad con éxito, es un desafío apasionante para la investigación con futuros docentes que deberán integrarse a contextos educativos y afrontar múltiples situaciones estresantes surgidas de la tarea misma. Los profesores se enfrentan a sucesos vitales estresantes que según la literatura se visualizan en la violencia, exclusión social, la conflictividad familiar y la incapacidad de la escuela para compensar las carencias y desigualdades, entre otros.Cuando se habla de inteligencia emocional en el contexto educativo no se puede dejar de lado el importante papel del profesorado en este campo. Este estudio se propone analizar las competencias socioemocionales instrumentadas por los futuros profesores del Instituto Superior del Profesorado Superior J.V. González de la Ciudad Autónoma de Buenos Aires, Argentina, al afrontar estresores vitales específicos a la práctica docente.","palabras_clave":"comptencias socioemocionales|afrontamiento|practicas docentes|futuros docentes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18398,"idioma_id":5,"titulo":"FIBROMATOSIS GINGIVAL IDIOPATICA UNILATERAL: REPORTE DE UN CASO CON CUATRO AÑOS DE SEGUIMIENTO","resumen":"La fibromatosis gingival es una enfermedad rara que se caracteriza por aumento del tejido gingival por proliferación fibrosa, es de crecimiento lento, cubriendo en algunos casos la totalidad de los dientes comprometidos Esta nosología comprende un grupo heterogéneo de patologías de causas no determinadas. El objetivo de este trabajo es presentar un caso clínico de una paciente de 13 años con FGI Unilateral, su diagnóstico, tratamiento y seguimiento durante cuatro años.   Presenta al examen clínico intraoral, agrandamiento anormal de su encía tanto superior como inferior, afectando solamente las hemiarcadas del sector izquierdo. A la palpación es indolora y de consistencia fibrosa. No se encontraron factores locales que justifiquen dicho aumento. El examen físico elimina la posibilidad de otras patologías asociadas, no refiriendo recibir medicaciones inmunosupresivas, antiepilépticos o antihipertensivas. No tiene antecedentes familiares. La paciente fue sometida a extirpación quirúrgica del tejido  hiperplasiado y el material obtenido enviado a estudio histopatológico.  Después del tratamiento quirúrgico y una buena higiene oral con exámenes de control efectuados durante cuatro años no se observó recurrencia. A pesar de ser una patología poco frecuente el odontólogo debe conocer la fisiopatología y comprender que el manejo de ésta enfermedad es a través de un equipo multidisciplinario. El diagnóstico precoz y el tratamiento oportuno logran la recuperación psicológica, estética y funcional de los pacientes.","palabras_clave":"Fibromatosis Gingival Idiopática|Diagnóstico diferencial"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18399,"idioma_id":5,"titulo":"ANALISIS DEL CONTENIDO DE VITAMINA C Y ROTULADO DE BEBIDAS ANALCOHOLICAS DE OFERTA HABITUAL  EN LA CIUDAD DE RESISTENCIA (CHACO, ARGENTINA)","resumen":"Las bebidas analcohólicas en Argentina son de alto consumo, pudiendo ser una de las principales vías de ingesta de vitamina C para la población. Las formas biológicamente activas de esta vitamina son el ácido L-ascórbico y L-dehidroascórbico. En este trabajo se presentan los resultados de un relevamiento efectuado sobre 52 productos que forman parte de la oferta habitual de estas bebidas en la ciudad de Resistencia (Chaco, Argentina). Se determinó el contenido de ácido ascórbico total por cromatografía líquida de alta eficiencia (HPLC) y analizó la rotulación de los productos, a fin de registrar los ingredientes utilizados en su formulación y verificar el cumplimiento de las normativas vigentes. Se obtuvieron niveles de ácido ascórbico en un rango de 0 a 82,36±4,84 mg\/200mL, correspondiendo los mayores valores a los productos sabor a naranja. Se determinaron  niveles de ácido ascórbico inferiores en el 42% de los productos, según la declaración del rótulo. Los valores de pH de las bebidas fueron inferiores a 4,092±0,268. Con respecto a los ingredientes utilizados en la formulación de bebidas no dietéticas, el azúcar junto con el jarabe de alta fructosa (JMAF) fueron muy utilizados como edulcorantes. En los productos dietéticos, el aspartamo, acesulfame K,  sucralosa, JMAF, sacarina y ciclamatos fueron empleados. El ácido cítrico es el acidulante universal y en los productos sabor a manzana también se adiciona el ácido málico. Algunos de los productos tienen colorantes, en especial tartrazina y amarillo ocaso, aunque también es utilizado el caramelo, TiO2, amaranto, etc. Se encontró que en general la rotulación de los productos cumple con lo exigido por la normativa vigente en cuanto a  'información obligatoria': denominación de venta, ingredientes, contenido neto, origen, lote, fecha de duración, preparación e instrucciones de uso y que todos los productos incluyen la información nutricional en las condiciones establecidas por la reglamentación.","palabras_clave":"VITAMINA C|BEBIDAS ANALCOHOLICAS|ROTULADO|COLORANTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18400,"idioma_id":4,"titulo":"Association of a BTA1 region with age at puberty in Angus bulls","resumen":"Age at puberty is an important component of reproductive performance in cattle, so it is important to identify genes that contribute to the regulation of the onset of puberty and polymorphisms that explain differences between bulls. In a previous study, we found putative associations between SNPs in chromosomes 1 and X and age at puberty in Angus bulls. In the present work we aimed to confirm these findings in a larger sample of Angus bulls (n=276). Four SNPs located into these regions were genotyped using SEQUENOM technology and the obtained genotypes were associated with age at puberty. The results showed that SNPs rs135953349 and rs110604205 on BTA1 were still significantly associated with age of puberty estimated at progressive sperm motility of 10% (p&lt;0.05). The association found previously on chromosome X could not be confirmed. The analysis of the bovine genome revealed that the associated region (99.17 ? 99.99 Mb) contained four predicted loci: MECOM (MDS1 and EVI1 complex locus), LOC100337483 (eGF-like and EMI domain containing 1 pseudogene-like), MIR551B (microRNA mir-551b) and LOC100139843 (mCG140927-like). The results obtained could contribute to the understanding of puberty regulation and could be useful for further identification and annotation of gene function in the context of reproduction.","palabras_clave":"gene|genetics|livestock|genotyping|polymorphism"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18401,"idioma_id":4,"titulo":"SYNERGISTIC ANTITUMOR EFFECTS OF MELATONIN AND PUFAS FROM WALNUT SEEDS IN A MURINE MAMMARY ADENOCARCINOMA MODEL","resumen":"Objective: We studied the effects of some PUFAs plus phytomelatonin from walnuts seeds in mammary gland adenocarcinoma (M3) development.  Methods: BALB\/c mice were fed a semi-synthetic diet supplemented with either: 6% walnut oil and 8% walnut flour containing phytomelatonin (Walnut diet: WD); or 6% corn oil plus commercial melatonin (Melatonin diet: MD) or the control group (CD) which received only 6% of corn oil. Membrane fatty acids of tumor cells (TC) were analyzed by gas liquid chromatography, cyclooxygenases (COXs) and lipoxygenases (LOXs) derivatives and plasma melatonin by HPLC; apoptosis and tumor infiltrating lymphocytes by flow cytometry.   Results: TC from MD and WD significant decreases in Linoleic acid compared to the CD group (p< 0.05). Significantly lower levels of LOXs-[13(S)-HODE] were found in TC from MD and WD than in CD (p <0.0001). COXs-[12 (S)-HHT] was lower and 12 LOXs-[12 (S)-HETE] was higher in TC from MD than WD and CD (p< 0.05). Plasma melatonin, apoptosis, tumor infiltration and survival time were significantly lower in CD than in MD and WD (p< 0.05).   Conclusions: This study shows that melatonin, along with PUFAs, exerts a selective inhibition of some COXs and LOXs activities and has a synergistic antitumor effect on a mammary gland adenocarcinoma model","palabras_clave":"cancer|Phytomelatonin|PUFAs|eicosanoids"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18402,"idioma_id":4,"titulo":"Reproductive cycle and oviposition in  Zidona dufresnei  (Caenogastropoda: Volutidae) from northern Patagonia, Argentina","resumen":"          This study describes the reproductive cycle in the  edible marine snail Zidona dufresnei in  San Antonio Bay (Patagonia, Argentina), an unusual population that?s inhabits  shallow waters. Histological techniques together with monthly field  observations&nbsp; over a two year period were  used to describe the gametogenic cycle, the season of oviposition and the  presence of egg capsules. Females were mature from August to April and there  was proliferation of the germinal epithelium immediately after evacuation.  Growth and resorption of oocytes was observed throughout all the study period.  Males were reproductively active throughout the year. The histological analysis  is consistent with the observations in nature, in which females were recorded  depositing egg capsules from late August to late April. The reproductive period seems to be closely related to water temperature  and photoperiod. The relatively high sea water temperature in San  Antonio Bay may be one of the relevant factors that contributes to the extended  period of oviposition and gamete evacuation in Z. dufresnei.&nbsp;           &nbsp;  ","palabras_clave":"gastropod|reproduction|patagonia|Spawn"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18403,"idioma_id":5,"titulo":"LA COBERTURA ARBÓREA EN UN SISTEMA SILVOPASTORIL DEL CHACO Y SU CONTRIBUCIÓN DIFERENCIAL AL SUELO","resumen":"En la región chaqueña la tecnología denominada rolado selectivo de baja intensidad (RBI) y siembra de Panicum maximum  permite controlar las leñosas e incrementar la productividad forrajera. Está poco esclarecido el efecto que tendrían estas prácticas en el suelo. El objetivo fue evaluar el impacto de la transformación de bosques nativos a sistemas silvopastoriles sobre las fracciones de carbono, nitrógeno y respiración del suelo. Los tratamientos fueron bosque nativo como testigo (T) y un sistema silvopastoril implementado mediante rolado y siembra simultánea de Panicum maximum cv gatton panic (RBI). El factor cobertura estuvo representado por suelo sin cobertura arbórea (D), bajo cobertura de Aspidosperma quebracho blanco (Qb) y bajo cobertura de Ziziphus mistol (M).El RBI mantiene las reservas de carbono del suelo y la cobertura arbórea nativa reviste vital importancia en la conservación de la materia orgánica y en el mantenimiento de la actividad microbiana. El contenido de carbono, nitrógeno y la actividad microbiana del suelo está en función de la cobertura ya que los niveles de COS, COP, NT y RE son menores en el suelo sin cobertura arbórea, intermedios bajo Aspidosperma quebracho blanco y mayores bajo el dosel de Ziziphus mistol por el mayor aporte de residuos por parte de esta última especie. El efecto conjunto de una perturbación mínima y gran ingreso de residuos orgánicos frescos determina mejores condiciones para el funcionamiento de los microorganismos heterótrofos, con efectos positivos en el almacenamiento de C en el horizonte superficial. Este trabajo demuestra que el RBI con siembra de Panicum maximum cv gatton panic no afecta la calidad del suelo en la región chaqueña.","palabras_clave":"FRACCIONES|CARBONO|MINERALIZACION|NITROGENO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18404,"idioma_id":4,"titulo":"Carbamates: A study on genotoxic, cytotoxic, and apoptotic effects induced in Chinese hamster ovary (CHO-K1) cells","resumen":"In vitro effects of the carbamates pirimicarb and zineb and their formulations Aficida® (50% pirimicarb) and Azzurro® (70% zineb), respectively, were evaluated in Chinese hamster ovary (CHO-K1) cells. Whereas the cytokinesis-blocked micronucleus cytome assay was employed to test for genotoxicity, MTT, neutral red (NR), and apoptosis evaluation were used as tests for estimating cell viability and succinic dehydrogenase activity, respectively. Concentrations tested were 10-300 µg\/ml for pirimicarb and Aficida®, and 1-50 µg\/ml for zineb and Azzurro®. All compounds were able to increase the frequency of micronuclei. A marked reduction in the nuclear division index was observed after treatment with 5 µg\/ml of zineb and Azzurro® and 10 µg\/ml of Azzurro®. Alterations in the cellular morphology not allowing the recognition of binucleated cells exposed to 300 µg\/ml pirimicarb and Aficida® as well as 10-50 µg\/ml zineb and Azzurro®. All four compounds induced inhibition of both cell viability and succinic dehydrogenase activity and trigger apoptosis in CHO-K1 cells, at least when exposed for 24 h. The data herein demonstrate the genotoxic and cytotoxic effects exerted by these carbamates and reveal the potential risk factor of these pesticides, still extensively used worldwide, for both human health and the environment.","palabras_clave":"Carbamatos|Genotoxididad|Citotoxicidad|Apoptosis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18405,"idioma_id":4,"titulo":"Incidental Renal Findings during 99mTc-MDP Biological Distribution Assay. The Role of Small Animal Imaging","resumen":"The present work aims to report an incidental renal finding during a bone scintigraphy performed as an additional exploratory study during a biological distribution assay as part of the quality control of 99mTc-labeled methylene disphosphonate (99mTc-MDP). Radiolabelling and quality control of 99mTc-MDP were performed according to the instructions of the manufacturer as well as to the USP monograph. After euthanasia and prior to dissection in the biological distribution, bone scintigraphy was carried on using a small field of view gamma camera. Finally, after dissection images of the kidneys were acquired. The uptake of 99mTc-MDP in the kidneys was calculated as the uptake of each kidney with regard to total renal uptake. Imaging analysis showed a remarkable difference in 99mTc-MDP uptake between right and left kidney (15.0% and 85.0% respectively). Lateral views confirmed anatomical positioning of kidneys and counting. Confirmation of the differential uptake in kidneys of the radiopharmaceutical was also achieved by ex vivo techniques [92.8% for left kidney and 7.2% for right kidney measured ex vivo in gamma camera; and 91.6% for left kidney and 8.4% for right kidney measured in a well-type gamma counter]. The present work clearly demonstrates that the comprehensive assessment of the biological behavior of radiopharmaceuticals assayed in experimental animals by using the small animal imaging approach, contributes more efficiently to the interpretation of the results. In this case, it was possible to detect incidental renal abnormalities that influenced the outcome of the biological distribution assay of 99mTc-MDP ex vivo techniques [92.8% for left kidney and 7.2% for right kidney measured ex vivo in gamma camera; and 91.6% for left kidney and 8.4% for right kidney measured in a well-type gamma counter]. The present work clearly demonstrates that the comprehensive assessment of the biological behavior of radiopharmaceuticals assayed in experimental animals by using the small animal imaging approach, contributes more efficiently to the interpretation of the results. In this case, it was possible to detect incidental renal abnormalities that influenced the outcome of the biological distribution assay of 99mTc-MDP","palabras_clave":"3Rs|radiopharmaceuticals|renal findings|small animal imaging|biological distribution, |99mTc-MDP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18406,"idioma_id":5,"titulo":"Modificación cuali-cuantitativa de estudios dinámicos renales por interacción con medios de contraste iodado","resumen":"El estudio reporta la modificación de los estudios dinámicos renales con radioisó-topos (EDRR) en animales control después de la administración de medios de contraste iodado (MCI). Se realizó EDRR con 99mTc-DTPA (37MBq) en ratas (n = 9, Sprague Dawley) adquiriendo un cuadro\/s durante el primer minuto y luego un cuadro\/15 s, completando los 30 min. Una semana después se repitió el EDRR una hora después de la administración intravenosa de MCI. Los resultados mostraron que las curvas basales se encontraban dentro de los patrones norma-les esperados, TMAX 3,1 ± 1,8 min, T50%Mx 7,25 ± 1,90 min y valores de función renal relativa (FRR) normales, 50,0 ± 4,3%. Las curvas post-MCI mostraron cambios cualicuantitativos como prolongación del TMAX hasta 12 min, la fase de eliminación compatible con un patrón obstruc-tivo y la FRR se mantuvo dentro del rango normal. En conclusión, el MCI interfirió con la función renal normal como se demuestra en el EDRR. 99mTc-DTPA (37MBq) en ratas (n = 9, Sprague Dawley) adquiriendo un cuadro\/s durante el primer minuto y luego un cuadro\/15 s, completando los 30 min. Una semana después se repitió el EDRR una hora después de la administración intravenosa de MCI. Los resultados mostraron que las curvas basales se encontraban dentro de los patrones norma-les esperados, TMAX 3,1 ± 1,8 min, T50%Mx 7,25 ± 1,90 min y valores de función renal relativa (FRR) normales, 50,0 ± 4,3%. Las curvas post-MCI mostraron cambios cualicuantitativos como prolongación del TMAX hasta 12 min, la fase de eliminación compatible con un patrón obstruc-tivo y la FRR se mantuvo dentro del rango normal. En conclusión, el MCI interfirió con la función renal normal como se demuestra en el EDRR. ","palabras_clave":"Medios de contraste;|Interacción farmacocinetica|Renograma;|Imágenes en pequeños animales|Medicina nuclear"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18407,"idioma_id":4,"titulo":"Genetic and morphological characterization of Acroceras macrum Stapf","resumen":"Acroceras macrum is a warm-season grass used for pastures and it has high nutritive value. The scarce genetic and reproductive information of this grass is limiting its breeding for forage. The objective of this research was to determine the number of genotypes and cytotypes present in a collection established in Argentina, and to estimate the diversity of this species based on molecular markers, morphological and agronomic characteristics. The number of genotypes among 47 accessions was determined using ISSR markers. The identified genotypes were further characterized for ploidy levels. In addition, the genetic distances among them were estimated with ISSR markers. They were also propagated and planted into the field following a randomized complete block design with four replications, and a group of 16 morphological and agronomic variables were evaluated. A total of 27 genotypes were identified in this collection; 22 genotypes were tetraploid (2n=4x=36) and 5 were hexaploid (2n=6x=54). These two cytotypes were found clearly separated by both genetic and phenotypic characteristics. Above-ground biomass, internode length, initial growth and number of spikelets per inflorescence were the most variable traits. The high diversity present in this collection will allow for the initiation of a breeding programme for A. macrum.","palabras_clave":"ACROCERAS|NILE GRASS|POLYPLOIDY|GENETIC CHARACTERIZATION|FORAGE BREEDING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18408,"idioma_id":4,"titulo":"TiO2 Supported on HZSM-11 Zeolite as Efficient Catalyst for the Photodegradation of Chlorobenzoic Acids","resumen":"The photocatalytic decomposition of 2-, 3- and 4-chlorobenzoic acids (2CB, 3CB and 4CB,respectively) with TiO2 loaded on HZSM-11 zeolite was investigated. The optimum decompositionrate of 2CB was obtained with TiO2\/HZSM-11(30%) (TiO2 30 wt.%) catalyst at a concentrationof 1 mg mL-1. 2CB and 3CB decompose at similar rates, but 4CB remains adsorbed onTiO2\/HZSM-11(30%) without further degradation. This absorption is attributed to the relativepositions of Cl and COOH groups on 4CB. However, this compound can be partially degradedand\/or removed from aqueous solutions by TiO2\/HZSM-11(50%) catalyst or HZSM-11 zeolite.TiO2\/HZSM-11(30%) is stable; it retains its photocatalytic properties after nine cycles, can beeasily removed and immediately reused. These are important advantages of TiO2\/HZSM-11(30%)over unsupported TiO2, making it a good photocatalyst for the treatment of polluted water. Onthe other hand, HZSM-11 could be used to selectively adsorb 4CB, thus becoming an alternativemethod of environmental remediation.","palabras_clave":"aromatic acids|heterogeneous photocatalysis|supported catalysts|TiO2|zeolite"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18409,"idioma_id":5,"titulo":"Implementación de un prototipo para el accionamiento de un motor de inducción usando energía solar fotovoltaica","resumen":"Se presenta la implementación de un sistema que permite controlar la velocidad de un motor de inducción trifásico utilizando la energía proveniente de un panel fotovoltaico. El sistema está compuesto por un convertidor CC-CC aislado que está conectado a un panel fotovoltaico y a un inversor trifásico que alimenta al motor de inducción. Se presentan resultados experimentales que validan el comportamiento del sistema propuesto.","palabras_clave":"PANEL FOTOVOLTAICO|INVERSOR TRIFASICO|CONVERTIDOR CC-CC AISLADO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18410,"idioma_id":4,"titulo":"Syndromes of collateral-reported psychopathology for ages 18-59 in 18 Societies","resumen":"El propósito fue avanzar en la metodología clínica y de investigación   de la evaluación psicopatológica mediante el examen de la generalización   internacional de un modelo de 8 síndromes derivados de evaluaciones de   personas allegadas a adultos, en sus problemas emocionales, sociales y   de pensamiento. Informantes allegados a los adultos calificaron a 8.582   residentes de 18 países entre 18 y 59 años de edad con el Adult Behavior   Checklist (ABCL). Un análisis factorial confirmatorio examinó el ajuste   del modelo de 8 síndromes a las puntuaciones provenientes de cada país.   El índice primario de ajuste del modelo (RMSEA) mostró un buen ajuste   del modelo para todas las sociedades, mientras que índices secundarios   (TLI, CFI) mostraron un ajuste de aceptable a bueno para 17 países. Las   cargas factoriales fueron robustas a través de los países e ítems. Los   hallazgos son consistentes con evidencia previa existente para la   generalización del modelo de 8 síndromes en autoinformes de 29   sociedades. Además, los resultados respaldan el modelo de 8 síndromes   para operacionalizar fenotipos de psicopatología del adulto provenientes   de evaluaciones de múltiples informantes en diversas sociedades.","palabras_clave":"Collateral reports|Multicultural|International|Adult Behavior Checklis|Descriptive survey study"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18411,"idioma_id":4,"titulo":"Circadian rhythms of proliferation events in two mouse carcinomas","resumen":"We studied the index of DNA synthesis (DNAs) of two cellular carcinomas: the hepatocellular ES12a and the mammary TN60 of mice, throughout one circadian cycle. In the results we observed that both tumors have circadian rhythms (CR), but the peaks of DNA synthesis (DNAs) vary. Besides, the mean of DNAs along 24 hours show significative differences, the TN60 have higher values than the ES12a. These observed CR in the DNAs index in both carcinomas mean that, at least in partly, the proliferation of cancer cells can be regulated by endocrine factor as it normally occurs in ordinary cells. The big problem we can find for the chronopharmacology is that it is impossible to know in advance the rate of proliferation of each tumor.","palabras_clave":"Tumor|ritmo circadiano"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18412,"idioma_id":4,"titulo":"Effect of the rearing system on the establishment of different functional groups of microorganism in the rumen of kid goats","resumen":"This study was aimed to determine the effect of the rearing system on the establishment and development of different functional groups of microorganisms in the rumen of kid goats. Fifty kids were fed on goat milk until weaning at 45 (TR, traditional rearing system, n = 25) and 30 days of age (alternative rearing system, AR, n = 25). In addition, only AR group was offered with rumen starter from birth. Both groups consumed alfalfa hay and ground corn between 30 and 90 days of age. Five kids from each group were slaughtered at 21, 30, 45, 70 and 90 days old. It was determined the total number of protozoa, anaerobic, amylolytic and cellulolytic bacteria present in the rumen. Kids of AR were lighter in weight than TR kids between 42 and 56 days old. In both rearing systems, anaerobic and amylolytic bacteria were found at 21 days of age, while cellulolytic and protozoa were not found until 45 days of age. Kids of AR had higher quantities of anaerobic and amylolytic bacteria until 30 and 45 days of age, respectively. These results demonstrate the rearing system does not affect the sequence and time in which the functional groups of microorganisms are established in the rumen. However, the alternative rearing system with early intake of solid food allowed the establishment of greater amount of bacteria and protozoa. Nevertheless, the effect of weaning on growth rate was more marked in kids from alternative rearing system, despite its greater microbiological rumen development.","palabras_clave":"KID GOATS|REARING SYSTEM|RUMEN MICROBIOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18413,"idioma_id":4,"titulo":"Palynology of the La Deheza Formation (Upper Palaeozoic),  Paganzo Basin, San Juan Province, Argentina","resumen":"We present the first palynological study of the La Deheza Formation in Paganzo Basin, San Juan Province, Argentina. A total of eighteen samples were studied and one hundred and sixteen palynomorph species were recorded. A multivariate statistical (R) analysis confirmed the occurrence of three associations. Assemblages 1 (240 m), 2 (230 m) and 3 (220 m) were referred to biozones already registred in the Paganzo Basin, i.e. Raistrickia densa-Convolutispora muriornata (DM), Pakhapites fusus-Vittatina subsaccata (FS) and Lueckisporites-Weylandites (LW) biozones. These Assemblages can be assigned a Pennsylvanian?Cisularian age based on previous stratigraphic records of the identified species.","palabras_clave":"palynology|La Deheza Formation|Upper Palaeozoic|San Juan"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18414,"idioma_id":5,"titulo":"Prólogo","resumen":"Millcayac Revista Digital en Ciencias Sociales, Volumen 2, Número 2, es en memoria de Alieda Verhoeven, por su compromiso militante por los derechos humanos, su conciencia ecuménica, su preocupación por articular el mundo de la vida y la espiritualidad o la religiosidad en Nuestra América, por su coherencia entre discurso y práctica, sus reflexiones críticas, por su acciones políticas y teológicas en procura de superar las desigualdades y las dominaciones de género, por su perseverante búsqueda por la verdad, la memoria y la justicia. Pero en especial, porque estamos convencidas que la reconstrucción de nuestras genealogías de mujeres y feministas implica un trabajo de complejas elaboraciones, re-narraciones, escrituras testimoniales y rastrillajes profundos para reparar \/ descubrir \/ rescatar las piezas claves para el armado de los inestables mosaicos de nuestra memoria.","palabras_clave":"GENEALOGÍAS FEMINISTAS|ALIEDA VERHOEVEN|CIENCIAS SOCIALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18415,"idioma_id":4,"titulo":"The  Amazonian Goblin Spiders of the New Genus Gradunguloonops (Araneae: Oonopidae)","resumen":"A new genus of soft-bodied oonopids, Gradunguloonops, is established for a group of goblin spiders found in the Amazonian rainforests of northern South America. Members of this genus differ from other oonopids in that the proclaw of tarsi I and II is notably larger than the corresponding retroclaw, a putative synapomorphy of the group. Gradunguloonopscomprises twelve species, all new and described in this contribution: G. mutum (type species) from Brazil and Peru, G. bonaldoi, G. amazonicus, G. urucu, G. pacanari, G. juruti from Brazil, G. erwini from Peru, G. orellana and G. nadineae from Ecuador, G. benavidesae and G. florezi from Colombia, and G. raptor from Venezuela. Two preliminary intrageneric groups are proposed on the basis of their female genital morphology: the bonaldoi group, to which are assigned the species with the anterior section comprising only a single anterior sclerite, and the mutum group, with a more complex, tripartite anterior section.","palabras_clave":"NEOTROPICAL REGION|NEW SPECIES|TAXONOMY|GENITAL MORPHOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18416,"idioma_id":5,"titulo":"La percepción de peligro y competencia como factores predictores del prejuicio hacia diferentes grupos sociales","resumen":" El prejuicio ha sido  descrito como un fenómeno generalizado ya que individuos prejuiciosos  hacia determinados grupos sociales también suelen serlo hacia otros. Sin embargo,  estudios recientes indican que la percepción de peligro expresada por el autoritarismo del  ala de derechas y la percepción de competencia intergrupal, expresada por la orientación a la dominancia social, podrían ser factores diferenciales en la explicación del prejuicio generalizado. El objetivo  principal de este trabajo fue analizar la dimensionalidad del prejuicio  generalizado, para luego dar cuenta si el autoritarismo del ala de derechas y  la orientación a la dominancia social son predictores de  diversas formas de prejuicio. Participaron del estudio 376 estudiantes universitarios  de la Ciudad de Buenos Aires con edades entre 18 y 42 años (M = 23.17; DT = 3.1), de los cuales 42,1%  eran hombres. Los resultados principales indicaron la presencia de tres  dimensiones que agrupaban diferentes grupos sociales, explicados  diferencialmente por la orientación a la dominancia social y el autoritarismo del  ala de derechas. Estos hallazgos refuerzan la noción del prejuicio generalizado como un fenómeno complejo y multidimensional, explicado  diferencialmente por la percepción de peligro y competencia que se manifiesta a  través de los niveles de autoritarismo y dominancia.INDEXACIONES: Dialnet, DICE , EBSCO, e-Revist@s, DOAJ, J-Gate, Latindex (catálogo), PSICODOC, Redalyc , SciELO, ULRICH?S.        ","palabras_clave":"PREJUICIO|DISCRIMINACION|RWA|SDO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18417,"idioma_id":5,"titulo":"De los bloopers a los youtubers. Diez años de Youtube en la cultura digital","resumen":"El presente artículo propone una aproximación general al sitio web para ver videos más relevante de Internet. Entre las cuestiones por abordar, se encuentra el crecimiento que experimentó la plataforma a lo largo de los años. También se describirán y analizarán cuáles son sus características primordiales, como así también algunas de las posibilidades que les otorga a sus usuarios y visitantes. Finalmente, se expondrán algunos de los géneros y formatos que se originaron durante la década que ostenta YouTube en línea, y mientras nos ocuparemos puntualmente de los youtubers, este nuevo tipo de navegantes surgido en sus aguas, mediante el análisis de algunos de los casos más significativos a nivel mundial y regional.","palabras_clave":"YouTube|Audiovisual|Formatos|Youtubers"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18418,"idioma_id":4,"titulo":"Imagining Guaranis and Jesuits. Yesterday s History, Today s Perspective","resumen":"        Throughout the last three hundred years, historical  literature and fiction have found a frequent theme in the missions. The Jesuits  spread news about this distant corner of the American colonies through the  European continent and provided valuable information about the natives with  whom they had had contact.  Reacting to  this information, the European public soon developed highly polarized opinions.  While apologetic stances defended the missions as a noble experiment of  civilizing the indigenous people who resided in the forest, the anti-Jesuit  position perceived the religious order as exploiters of the natives who sought  to create a kingdom independent from the Spanish and Portuguese crowns. This paper briefly explores  Jesuit missions historiography and sumarizes recent approaches to the issue.   ","palabras_clave":"Jesuit Missions|Guarani|Literature|Historiography"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18419,"idioma_id":4,"titulo":"In vitro activity of amphotericin B, terbinafine and azole drugs against clinical and environmental isolates of Aspergillus terreus sensu stricto","resumen":"According with CLSI document M38-A2 the antifungal susceptibility of 40 clinical and environmental isolates of A. terreus sensu stricto against amphotericin B, terbinafine, itraconazole and voriconazole was performed. For itraconazole and voriconazole all isolates showed lower MICs than epidemiologic cutoff values and the 5% of the isolates presented higher amphotericin B MICs than epidemiologic cutoff values. Terbinafine showed the lowest MICs. No significant differences were found when MICs of clinical and environmental isolates were compared.","palabras_clave":"ANTIFUNGAL SUSCEPTIBILITY TESTING|ASPERGILLUS TERREUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18420,"idioma_id":4,"titulo":"Types of Borderline Personality Disorder (BPD) in Patients Admitted for Suicide-Related Behavior","resumen":"Borderline personality disorder (BPD) is determined by the presence of any five of nine diagnostic criteria, leading patients with heterogeneous clinical features to be diagnosed under the same label without an individualized clinical and therapeutic approach. In response to this problem, Oldham proposed five types of BPD: affective, impulsive, aggressive, dependent and empty. The present study categorized a sample of BPD patients hospitalized due to suicide-related behavior according to Oldham's BPD proposed subtypes, and evaluated their clinical and demographic characteristics. Data were obtained from a sample of 93 female patients admitted to the « Dr. Braulio A. Moyano » Neuropsychiatric Hospital following suicide-related behavior. A total of 87 patients were classified as affective (26 %), impulsive (37 %), aggressive (4 %), dependent (29 %), and empty (5 %). Patients classified as dependent were significantly older at the time of first suicide-related behavior (p = 0.0008) and reported significantly less events of previous suicide-related behaviors (p = 0.03), while patients classified as impulsive reported significantly higher rates of drug use (p = 0.02). Dependent, impulsive and affective BPD types were observed most frequently in our sample. Findings are discussed specific to demographic and clinical implications of BPD patients reporting concurrent suicidal behavior.","palabras_clave":"Borderline personality disorder types|Suicide-related behavior|Inpatients"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18421,"idioma_id":4,"titulo":"Clozapine-associated neutropenia and agranulocytosis in Argentina (2007-2012)","resumen":"The risks of severe leukopenia and agranulocytosis have varied over time and among geographical regions and cultures, with little information available on South American populations. Accordingly, we reviewed and analyzed data from a 6-year experience monitored by an Argentine national registry to which reporting of adverse events reports is required. We analyzed data for 2007?2012 from the pharmacovigilance program of the Argentine drug-regulatory agency (ANMAT) using standard bivariate and multivariate statistical methods and survival analysis. We identified 378 cases of adverse hematological events over 6 years among an average of 12 305 individuals\/year treated with clozapine (308±133 mg\/day) to estimate the mean annualized rates of leukopenia [0.19 (95% confidence interval [CI] 0.11?0.27)], neutropenia [0.38 (95% CI 0.34?0.43)], and agranulocytosis [0.05 (95% CI 0.02?0.08)] % per year [median latency 2 (95% CI 1.3?2.1) months]; fatalities related to agranulocytosis averaged 4.2 (95% CI 0.0?9.2) per 100 000 treated individuals\/year. Factors associated significantly and independently with agranulocytosis were female sex, older age, and use of other drugs in addition to clozapine. With monitoring by international standards, recent risks of clozapine-associated agranulocytosis in Argentina were lower, but fatality rates were higher than that in other regions of the world. Risk factors include the use of multiple psychotropic drugs, female sex, and older age.","palabras_clave":"agranulocytosis|clozapine|Argentina|pharmacovigilance|leukopenia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18422,"idioma_id":4,"titulo":"Time Left for Intervention in the Suicidal Process in Borderline Personality Disorder","resumen":"The objective of this study was to measure the duration of the suicidal process among  patients diagnosed with Borderline Personality Disorder (BPD). The sample included  10 110 female patients who met DSM-IV-TR criteria for BPD and were consecutively  admitted after suicide-related behavior. A total of 63 patients (58%) reported that  their suicidal process lasted 10 minutes or less. After being adjusted, the ? coefficient  of impulsivity scales in women with a suicidal process ?10 minutes was lower compared  to those observed in women with »10 min (? ¼ 0.03, 95% CI ¼ 0.06 ¼  15 0.01, p < 0.01). Suicidal patients with BPD can be divided into two groups; patients  who report a suicidal process less than 10 minutes show a higher degree of impulsivity.  K","palabras_clave":"borderline personality disorder |impulsivity|suicide |suicidal process"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18423,"idioma_id":4,"titulo":"Effect of estradiol on apoptosis, proliferation and steroidogenic enzymes in the testes of the toad Rhinella arenarum (Amphibia, Anura)","resumen":"      Estrogens inhibit androgen production and this  negative action on amphibian steroidogenesis could be  related to the regulation of steroidogenic enzymes. Estrogens are also involved  in the regulation of amphibian spermatogenesis by controlling testicular  apoptosis and spermatogonial proliferation. The Bidder´s organ (BO) is a  structure characteristic from the Bufonidae family and in adult males of Rhinella arenarum it is one of the main  sources of plasma estradiol (E2). The purpose of this study is to  analyze the effect of E2 on testicular steroidogenic enzymes,  apoptosis and proliferation in the toad R.  arenarum. For this purpose, testicular fragments were treated during 24 h  with or without 2 nM or 20 nM of E2. After treatments, the activity of cytochrome P450 17a-hydroxylase-C17?20 lyase (CypP450c17) and 3b-hydroxysteroid dehydrogenase\/isomerase (3b-HSD\/I) were  measured by the transformation of radioactive substrates into products, and CypP450c17 expression was  determined by Western blot analysis. Apoptosis in testicular sections was detected  with a commercial fluorescent kit based on TUNEL method, and proliferation was evaluated  by BrdU incorporation.  Results indicate that E2 has no effect on CypP450c17 protein levels or enzymatic activity, while it reduces  3b-HSD\/I activity during the post  reproductive season. Furthermore, although E2 has no effect on  apoptosis during the pre and the post reproductive seasons, it stimulates  testicular apoptosis during the reproductive season, mostly in spermatocytes.  Finally, E2 has no effect on testicular proliferation all year long.  Taken together,  these results suggest that E2 is involved in the regulation of  testicular steroidogenesis and spermatogenesis.   ","palabras_clave":"TOAD|ESTRADIOL|SPERMATOGENESIS|STEROIDOGENESIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18424,"idioma_id":4,"titulo":"The Influence of Light on Mood","resumen":"Light is the most important environmental signal for the mammalian circadian system, and is detected exclusively by the eyes via specialized ganglion cell photoreceptors. Cycles of light and darkness relayed by the retina entrain suprachiasmatic nuclei neural activity, which in turn entrains the rhythmic production and secretion of melatonin from the pineal gland. Deficiencies on the daily and seasonal pattern of melatonin secretion seem to be one of the main causes of mood disorders. Since several studies confirmed that depressed patients show low concentrations of melatonin at night and that this could be an individual trait marker, the objective of this study was to test a hypothesis proposed by Stone to the lighting community in 1999 related to possible associations between glare sensitivity, melatonin response and depression. In the present research report, significant correlations were found between winter depression and melatonin production with age. On the other hand, sensitivity to glare significantly correlated with melatonin production during winter. Taken together, the results lend support for more investigation on these associations.","palabras_clave":"LIGHT|MELATONIN|MOOD|VULNERABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18425,"idioma_id":4,"titulo":"Quality retention of fresh-cut pepper as affected by atmosphere gas composition and ripening stage","resumen":"The responses of fresh-cut (FC) vegetables to CO2 and O2   levels depend on their ripening stage and degree of processing. In this   work we evaluated the effect of storage under different CO2 (2.5; 5; 10 and 15 kPa) and O2 (2.5 and 5 kPa) combinations or air on quality retention of FC green and red pepper. Atmospheres with 15 kPa CO2 caused physiological injury at both ripening stages. Red pepper strips were less tolerant to CO2 enrichment within the range 5-10 kPa. Ripe FC peppers were also more sensitive to O2 reductions below 5 kPa. Marked benefits were obtained at both ripening stages with 5 kPa O2+5 kPa CO2. CA-stored strips showed lower spoilage and dehydration and ion leakage. Storage under 5 kPa O2+5 kPa CO2   was highly effective to maintain the firmness and resistance to bending   of the strips. The selected CA caused no alterations in colour,   acidity, sugars and antioxidants and was effective to maintain lower   respiration rate. CA maintained lower counts of mesophilic bacteria,   yeasts and molds in red ripe strips.","palabras_clave":"Capsicum annuum L.   |Microbial growth|Texture|Color|Storage"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18426,"idioma_id":5,"titulo":"Argentina y Brasil. Alternativas del intervencionismo estatal en la agroindustria del azúcar, 1880-1938","resumen":"El texto propone un análisis comparativo de las diversas alternativas de intervención estatal en la agroindustria del azúcar que se implementaron en Brasil y Argentina a partir de la década de 1880. Crisis de sobreproducción, pérdida de competencia en el mercado internacional, conflictos entre diferentes actores y zonas productoras dieron origen a arreglos institucionales en los dos países que perseguían valorizar el producto, conciliar intereses y hacer previsible el comportamiento de un mercado siempre complejo. El análisis se cierra en 1937-1938 con la inauguración de la experiencia del Estado Novo en Brasil, que profundizó el intervencionismo, y el fracaso en la Argentina de un intento de aprobar una ley que habría involucrado de manera decisiva el Estado en el desarrollo azucarero.","palabras_clave":"Estado|Agroindustria Azucarera|Argentina|Brasil"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18427,"idioma_id":4,"titulo":"Analysis of capillary pressure effect on the seismic response of a CO2-storage site applying multiphase flow and wave propagation simulators","resumen":"We analyze the influence of capillary pressure on the seismic response of a saline aquifer, where CO2 has been stored in the Utsira Sand at the Sleipner field. For this purpose, we present a novel methodology integrating numerical simulation of CO2?brine flow and seismic wave propagation, using a geological model that includes mudstone layers and natural apertures. The simultaneous flow of CO2 and brinein an aquifer is modeled by the differential equations that describe the two-phase fluid flow in porous media. The multiphase flow functions are determined from well-log data, using the relation between resistivity index, relative permeabilities and capillary pressure. Seismic monitoring is performed with a wave equation that includes attenuation and dispersion effects due to mesoscopic scale heterogeneitiesin the petrophysical and fluid properties. The fluid simulator properly models the CO2 injection and upward migration, obtaining accumulations below the mudstone layers as injection proceeds. Moreover, we are able to identify the time-lapse distribution of CO2 from the synthetic seismograms, which show thetypical pushdown effect due to the spatial distribution of CO2. Finally, a sensitivity analysis is performed by modifying the capillary pressure threshold in order to evaluate its effect over the CO2 plume and the corresponding synthetic seismogram.","palabras_clave":"CO2 sequestration|Multiphase flow functions|Fluid flow simulation|Seismic monitoring"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18428,"idioma_id":4,"titulo":"Influence of  Temperature, Anions and Size Distribution on the Zeta Potential of  DMPC, DPPC AND DMPE Lipid  Vesicles?.","resumen":"The purpose of the work is to compare the influence of the multilamellarity, phase state, lipid head groups and ionic media on the origin of the surface potential of lipid membranes.   With this aim, we present a new analysis of the zeta potential of multilamellar and unilamellar vesicles composed by phosphatidylcholines (PC) and phosphatidylethanolamines (PE) dispersed in water and ionic solutions of polarizable anions, at temperatures below and above the phase transition.  In general, the adsorption of anions seems to explain the origin of the zeta potential in vesicles only above the transition temperature (Tc). In this case, the sign of the surface potential is ascribed to a partial orientation of head group moiety towards the aqueous phase. This is noticeable in PC head groups but not in PEs, due to the strong lateral interaction between PO and NH group in PE.                  ","palabras_clave":"PHOSPHOLIPIDS|MULTILAMELLAR VESICLES|UNILAMELLAR VESICLES|ZETA POTENTIAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18429,"idioma_id":4,"titulo":"Rehydration of Rosa rubiginosa Fruits Dried with Hot Air","resumen":"The effect of perforation, drying temperature, and rehydration  temperature on the rehydration kinetics of Rosa rubiginosa fruits  was investigated. Before drying, half of the fruit sample was perforated  three times at equidistant points along the equatorial plane of  the fruit, in order to speed up the drying process. Samples were dried  at various air temperatures (60, 70, and 80C), with an air velocity  of 5 m\/s and 5% relative humidity. Then, dried samples were  rehydrated at different temperatures (20, 40, 60, and 80C). The  rehydration kinetics was fitted by two empirical models, Peleg and  Weibull, and both represented the phenomenon well, in perforated  and nonperforated fruits. Regardless of the drying temperature,  the higher the rehydration temperature of rose hip fruits, perforated  or not, the higher the water absorption capacity. Temperature  dependence of the kinetic parameters was Ea=47.5 kJ\/mol (Peleg)  and 55.9 kJ\/mol (Weibull) for nonperforated fruits and  Ea=40.1 kJ\/mol (Peleg) and 45.5 kJ\/mol (Weibull) for perforated  fruits; thus, perforated fruits were influenced more by rehydration  temperature than nonperforated fruits. Perforated fruits rehydrated  30% faster than nonperforated fruits.","palabras_clave":"MODELING|PRETREATMENT|REHYDRATION|ROSA RUBIGINOSA FRUITS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18430,"idioma_id":10,"titulo":"Desempenho de motores de indução de alta eficiência alimentado por redes com problemas de qualidade de energia elétrica","resumen":"A norma IEC  60034-30 especifica classes de eficiência internacionais para motores de indução.  Sob condições ideais de alimentação, classes mais altas correspondem a melhores desempenhos energéticos. Mas o comportamento desses motores em redes com desequilíbrios de tensão e distorções harmônicas de tensão ainda não é totalmente conhecido. O estudo aqui relatado investigou os  efeitos dessas perturbações sobre a eficiência dos equipamentos.","palabras_clave":"Motores de inducción|Calidad de energía|desequilibrio de tensión|armónicos de tensión"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18431,"idioma_id":4,"titulo":"DISCOVERY OF SiO BAND EMISSION FROM GALACTIC B [e] SUPERGIANTS","resumen":"B[e] supergiants (B[e]SGs) are evolved massive stars in a short-lived transition phase. During this phase, these objects eject large amounts of material, which accumulate in a circumstellar disk-like structure. The expelled material is typically dense and cool, providing the cradle for molecule and dust condensation and for a rich, ongoing chemistry. Very little is known about the chemical composition of these disks, beyond the emission from dust and CO revolving around the star on Keplerian orbits. As massive stars preserve an oxygen-rich surface composition throughout their life, other oxygen-based molecules can be expected to form. As SiO is the second most stable oxygen compound, we initiated an observing campaign to search for first-overtone SiO emission bands. We obtained high-resolution near-infrared L-band spectra for a sample of Galactic B[e]SGs with reported CO band emission. We clearly detect emission from the SiO first-overtone bands in CPD-52 9243 and indications  for faint emission in HD 62623, HD 327083, and CPD-57 2874. From model fits, we find that in all these stars the SiO bands are rotationally broadened with a velocity lower than observed in the CO band forming regions, suggesting that SiO forms at larger distances from the star. Hence, searching for and analyzing these bands is crucial for studying the structure and kinematics of circumstellar disks, because they trace complementary regions to the CO band formation zone. Moreover, since SiO molecules are the building blocks for silicate dust, their study might provide insight in the early stage of dust formation.","palabras_clave":"Circumstellar matter|Infrared: stars|Stars: early-type|Stars: massive ? supergiants"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18432,"idioma_id":4,"titulo":"Diphyllobothrium sp. in Canis familiaris from the subtropical area of Argentina (Puerto Iguazú, Misiones)","resumen":"This paper reports the first finding of Diphyllobothrium sp. eggs in Canis familiaris (domestic dog) from Puerto Iguazú, a subtropical city of Misiones province, Argentina. In 2013, two positive cases of Diphyllobothrium sp. eggs were detected during an annual parasitological survey of dogs. Dog feces were collected in vials containing 10 % formalin and processed using Telemann´s sedimentation and Sheather´s flotation techniques. The two cases were detected in rural areas of the municipality. Since Misiones is not a part of the endemic area of diphyllobothriasis and given the fact that it is located in the three-border area of Argentina, Brazil and Paraguay, we consider this finding of great importance to public health. We stress the need for updating the current knowledge about the life cycle of these parasites considering the range of intermediate and definitive hosts, their zoonotic potential, and the epidemiological situation in non-endemic areas.","palabras_clave":"Diphyllobothrium|Domestic dog|Tapeworms|Zoonoses|Argentine subtropics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18433,"idioma_id":4,"titulo":"Uncovering the nucleus candidate for NGC 253","resumen":"NGC253 is the nearest spiral galaxy with a nuclear starburst which  becomes the best candidate to study the relationship between starburst  and AGN activity. However, this central region is veiled by large  amounts of dust, and it has been so far unclear which is the true  dynamical nucleus. The near infrared spectroscopy could be advantageous  in order to shed light on the true nucleus identity. Using Flamingos-2  at Gemini South we have taken deep K-band spectra along the major axis  and through the brightest infrared source. We present evidence showing  that the brightest near infrared and mid infrared source in the central  region, already known as radio source TH7 and so far considered just a  stellar supercluster, in fact, presents various symptoms of a genuine  galactic nucleus. Therefore, it should be considered a valid nucleus  candidate. It is the most massive compact infrared object in the central  region, located at 2.0' of the symmetry center of the galactic bar.  Moreover, our data indicate that this object is surrounded by a large  circumnuclear stellar disk and it is also located at the rotation center  of the large molecular gas disk of NGC 253. Furthermore, a kinematic  residual appears in the H2 rotation curve with a sinusoidal shape  consistent with an outflow centered in the candidate nucleus position.  The maximum outflow velocity is located about 14 pc from TH7, which is  consistent with the radius of a shell detected around the nucleus  candidate observed at 18.3 {mu}m (Qa) and 12.8 {mu}m ([NeII]) with  T-ReCS. Also, the Br_gamma emission line profile is blue-shifted and  this emission line has also the highest equivalent width at this  position. All these evidences point out TH7 as the best candidate to be  the galactic nucleus of NGC 253.","palabras_clave":"KINEMATICS|STRUCTURE|NUCLEI|INFRARED"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18434,"idioma_id":5,"titulo":"Develando con T-ReCS las regiones oscurecidas del nucleo starburst más cercano","resumen":"Presentamos las imagenes de la region nuclear de NGC 253 obtenidas con el instrumento T-ReCS (Thermal-Region Camera Spectrograph) del telescopio Gemini Sur. Las mismas fueron tomadas en las bandas Qa, Si-2, NeII, y continuo de NeII (18.3, 8.7, 12.8, 13.1 m respectivamente), con un muestreo espacial medio de  0.2' (3.4 pc). Se identican y analizan las subestructuras más importantes alrededor de los posibles núcleos y se discuten sus roles en el escenario dinámico de la galaxia.","palabras_clave":"GALAXIES|NUCLEUS|INFRARED"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18435,"idioma_id":4,"titulo":"Quantum state transfer in disordered spin chains: How much engineering is reasonable?","resumen":"The transmission of quantum states through spin chains is an important element in the implementation  of quantum information technologies. Speed and fidelity of transfer are the main  objectives which have to be achieved by the devices even in the presence of imperfections which are  unavoidable in any manufacturing process. To reach these goals, several kinds of spin chains have  been suggested, which differ in the degree of fine-tuning, or engineering, of the system parameters.  In this work we present a systematic study of two important classes of such chains. In one class  only the spin couplings at the ends of the chain have to be adjusted to a value different from the  bulk coupling constant, while in the other class every coupling has to have a specific value. We  demonstrate that configurations from the two different classes may perform similarly when subjected  to the same kind of disorder in spite of the large difference in the engineering effort necessary  to prepare the system. We identify the system features responsible for these similarities and we  perform a detailed study of the transfer fidelity as a function of chain length and disorder strength,  yielding empirical scaling laws for the fidelity which are similar for all kinds of chain and all disorder  models. These results are helpful in identifying the optimal spin chain for a given quantum  information transfer task. In particular, they help in judging whether it is worthwhile to engineer  all couplings in the chain as compared to adjusting only the boundary couplings.","palabras_clave":"quantum state transmission|fidelity|spin chains"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18436,"idioma_id":5,"titulo":"Currículum y construcción de un habitus investigativo cualitativo entre sociólogos en  formación","resumen":"Este artículo analiza el diseño curricular de un seminario de investigación socioeducativa cualitativa para sociólogos en formación, reflexionando acerca de su contribución en forjar un ?habitus investigativo cualitativo? entre estudiantes que asumen el rol de investigadores.  El trabajo recupera diferentes modos en que se ha problematizado la relación investigación-docencia en otras latitudes, para luego examinar los supuestos, objetivos y modalidades de trabajo del seminario y la utilización de Trabajos Prácticos secuenciales que vertebran la cursada. Se argumenta que esta experiencia de ?enseñanza basada en investigación? contribuiría a inculcar una concepción dialógica, reflexiva y situada de la investigación social.","palabras_clave":"HABITUS|CUALITATIVO|FORMACION|OFICIO DEL SOCIOLOGO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18437,"idioma_id":4,"titulo":"Business opportunities and risks in growing markets: Multinationals in Argentina during the first half of the twentieth century","resumen":"This article analyzes the global and local factors that shaped Foreign Direct Investment in Argentina and the strategies of foreign multinationals to adapt to challenging circumstances and to exogenous shocks from the early twentieth century to the emergence of a new global economy in the 1950s. The central argument is that Argentina was a host economy attractive to foreign investments, not only in the first globalization period but also after the crisis of 1930 when the global economy started to crumble. Foreign firms viewed Argentina as a growing economy offering diverse business opportunities in different periods, with the exception of the interregnum of World War II and the Peronist administration (1946-1955), when financial and political risks appeared. The article draws on a different approach to the more traditional stock-flows FDI analyses, relying on a new database of foreign-controlled companies that operated in Argentina in the twentieth century (FCAD).","palabras_clave":"MULTINATIONALS|ARGENTINA|INVESTMENT STRATEGIES|GLOBAL ECONOMY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18438,"idioma_id":4,"titulo":"Amidinoquinoxaline N-oxides as novel spin traps","resumen":"A novel type of spin traps 1 derived from the pyrimidoquinoxaline N-oxide heterocyclic core is reported. EPR technique was used to evaluate their ability to trap methyl radicals generated in a Fenton reaction in the presence of DMSO. All the synthesized nitrones showed spin trapping properties and the corresponding nitroxides 2 were characterized by EPR. The novel spin traps showed remarkably persistent signals, as evidenced in a competition experiment with DMPO. The addition rate constants leading to the spin adducts (kadd) were determined, and very good correlations were found with steric and electronic parameters of the parent nitrones. The spin adducts decomposition rate constants (kdec) and the corresponding half-life times (t1\/2) were also determined. DFT and MP2 calculations were used in order to rationalize the adducts hfcc and the structural factors influencing their addition and decomposition rates.","palabras_clave":"SPIN TRAPS|EPR|AMIDINOQUINOXALINES|MOLECULAR MODELLING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18439,"idioma_id":4,"titulo":"Atropisomerism in Amidinoquinoxaline N-Oxides: Effect of the Ring Size and Substituents on the Enantiomerization Barriers","resumen":"The atropisomerism of novel 2,3-dihydro1H-pyrimido[1,2-a]quinoxaline 6-oxides 1 bearing dissymmetric (ortho-substituted) 5-aryl residues and the homologous 1,2-dihydroimidazo[1,2-a]quinoxaline 5-oxides 2 was investigated. The existence of a chiral axis was demonstrated for compound 1a by X-ray diffraction and by DFT calculations of the ground state geometry. The resolution of the atropisomeric enantiomers on chiral stationary phases is reported. The barriers to enantiomerization were determined by off-line racemization studies and\/or by treatment of the plateau-shape chromatograms during chromatography on chiral support. A clear ring size effect was evidenced. In all cases, six-membered amidine derivatives 1 showed higher barriers than the corresponding lower homologues 2, which also display lower sensitivity to the substituent size. Transition states for the interconversion of the atropisomers were located using DFT calculations, and involved the interaction of the ortho substituent with the formally sp2 nitrogen in the amidine moiety. In contrast, in the most favoured enantiomerization transition state of the 2-nitro derivative the ortho substituent is close to the N-oxide group.","palabras_clave":"ATROPISOMERISM|CHIRAL HPLC|NITROGEN HETEROCYCLES|ENANTIOMERISATION BARRIERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18440,"idioma_id":4,"titulo":"Recent progress in the Horner-Wadsworth-Emmons reaction","resumen":"The Horner-Wadsworth-Emmons reaction is one of the most reliable and widespread synthetic tools for the stereocontrolled construction of ethylenic bonds. The versatility of the reaction makes it a valuable synthetic tool to prepare simple as well as densely functionalized and complex molecular scaffolds. This review is devoted to the recent evolution of the reaction, which considerably widens its product scope and synthetic potential. The main recent developments on the HWE reaction presented in this work comprise novel phosphonate reagents and sequential reactions involving the HWE olefination. Interesting applications, including access to challenging or complex synthetic targets, relevant organic compounds and natural products are also highlighted.","palabras_clave":"HORNER-WADSWORTH-EMMONS REACTION|CARBONYL OLEFINATIONS|FUNCTIONALIZED PHOSPHONATES|FUNCTIONALIZED OLEFINS|ONE-POT REACTIONS|TANDEM REACTIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18441,"idioma_id":5,"titulo":"Los lenguajes natural y simbólico en la enseñanza de Matemática Superior","resumen":"Nos interesa estudiar el lenguaje natural y el simbólico utilizado en el contexto de la enseñanza de Matemática superior. En particular desarrollamos una conceptualización del lenguaje simbólico que nos permite presentar explicaciones a dificultades que manifiestan docentes de nivel superior y que describimos en este trabajo. Las mismas se originan ante dos tipos de tareas: explicar en lenguaje natural el significado de una propiedad o definición que se presenta escrita en símbolos, o expresar en símbolos un texto escrito en lenguaje natural. El trabajo se desarrolló con docentes asistentes a un Curso de Capacitación que coordinamos en la Universidad Nacional de Salta, sede Orán en 2013. Algunas de las dificultades y explicaciones nos permiten proponer claves para la formación docente, tanto inicial como continua.","palabras_clave":"LENGUAJE SIMBOLICO|MATEMATICA SUPERIOR|FORMACION DE PROFESORES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18442,"idioma_id":4,"titulo":"Amyloidogenic propensity of a natural variant of human apolipoprotein A-I: stability and interaction with ligands","resumen":"A number of naturally occurring mutations of human apolipoprotein A-I (apoA-I) have been  associated with hereditary amyloidoses. The molecular mechanisms involved in amyloidassociated  pathology remain largely unknown. Here we examined the effects of the Arg173-  Pro point mutation in apoA-I on the structure, stability, and aggregation propensity, as well  as on the ability to bind to putative ligands. Our results indicate that the mutation induces a  drastic loss of stability, and a lower efficiency to bind to phospholipid vesicles at physiological  pH, which could determine the observed higher tendency to aggregate as pro-amyloidogenic  complexes. Incubation under acidic conditions does not seem to induce significant  desestabilization or aggregation tendency, neither does it contribute to the binding of the  mutant to sodium dodecyl sulfate. While the binding to this detergent is higher for the mutant  as compared to wt apoA-I, the interaction of the Arg173Pro variant with heparin depends on  pH, being lower at pH 5.0 and higher than wt under physiological pH conditions. We suggest  that binding to ligands as heparin or other glycosaminoglycans could be key events tuning  the fine details of the interaction of apoA-I variants with the micro-environment, and probably  eliciting the toxicity of these variants in hereditary amyloidoses.","palabras_clave":"APOLIPOPROTEIN A-I|AMYLOIDOSIS|HEPARIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18443,"idioma_id":4,"titulo":"Identification and molecular characterization of Orf virus in Argentina","resumen":"Orf virus (ORFV) is the etiological agent of contagious ecthyma (CE), a pustular dermatitis of sheep and goats. Outbreaks of ORFV have been observed in all geographical regions of the world, including Argentina. The origin and identity of Argentinian ORFVs are unknown, andno comparative or phylogenetic studies of these viruses have been performed. In this study, we described the sequencing and analysis of five ORFV molecular markers: a partial B2L gene (ORF011), VIR (ORF020), an envelope mature protein (ORF109), vIL10 (ORF127), and GIF (ORF117) from two particular Argentinian outbreaks of CE.","palabras_clave":"orf virus|contagious ecthyma|parapoxvirus|phylogenetic analysis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18444,"idioma_id":5,"titulo":"Discurso hegemónico vs resistencia cultural. El caso del proceso de apropiación de las tierras en la Patagonia argentina en el contexto de formación del estado-nación.","resumen":"En elpresente trabajo, a partir de los aportes teóricos de las pedagogías críticasreflexionamos y proponemos posibilidades de aplicación en las prácticas deenseñanza en las clases de Historia Contemporánea Argentina. Desde una miradamultidimensionalidad de la interculturalidad se propone que el aula en la quese enseña una lectura de la Historia pueda ser el ámbito de reflexiones sobre ladiversidad, espacio para el debate y el análisis de las constelacionesinfluyentes desde la perspectiva estructural, coyuntural y personal. El caso atrabajar es el proceso de incorporación de las tierras de la Patagonia en laconformación de mercado interno nacional en la coyuntura del modeloagroexportador de la Argentina como país periférico. Caso iniciado en las últimasdécadas del siglo XIX pero que aún tiene repercusión en el presente. En estacomunicación a partir del marco teórico señalado se revisará el discursohegemónico de la escuela tradicional&nbsp;presente en los libros de texto que justificaba la aniquilación de lascomunidades aborígenes en pro de la legitimación del estado nacional argentinoen el marco de la economía capitalista liberal del siglo XIX. A esa lecturacontraponemos textos actuales que informan sobre los movimientos de resistenciaen el discurso y la acción. &nbsp;","palabras_clave":"PEDAGOGIA CRITICA|INTERCULTURALIDAD|PRACTICA DOCENTE|DISCURSO HEGEMONICO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18445,"idioma_id":5,"titulo":"Evaluación de la carga microbiológica ambiental en áreas destinadas a producción y control de vacunas","resumen":"Objetivo: el objetivo del presente trabajo fue contribuir al aseguramiento de la calidad microbiológica de una planta de producción de vacunas, a través de la identificación de la carga microbiológica ambiental y su comportamiento frente a los desinfectantes utilizados de rutina. Método: Se estudió la flora residente de cada área clasificada. Se analizaron muestras de aire tomadas por los métodos volumétricos y sedimentación en placa. Las superficies y vestimenta del personal fueron evaluadas por el método de contacto. Se realizaron identificaciones en género y especie estableciéndose para cada área un Grupo de Microorganismos Indicador formado por microorganismos aislados con una frecuencia superior al 5 %. Resultados: Bioterio: Staphylococcus spp (50 %), Aerococcus spp (21 %), Micrococcus spp (10 %), Bacillus spp y Géneros Relacionados (6 %); Cultivos Celulares Normales: Staphylococcus spp      (48 %), Micrococcus spp (34 %), Bacillus spp y Géneros Relacionados (13 %); Control de Calidad: Staphylococcus spp (50 %), Micrococcus spp (27 %), Kocuria spp (9 %), Bacillus spp y Géneros Relacionados (7%); Producción: Staphylococcus spp (50 %), Micrococcus spp (17 %), Kocuria spp (11 %), Leuconostoc spp (8 %), Bacillus spp y Géneros Relacionados (6 %). El grupo indicador para la Unidad de Producción se identificó como Staphylococcus spp (49,5 %), Micrococcus spp. (23,0 %), Bacillus spp y Géneros Relacionados  (8,1 %). El desafío de los desinfectantes en uso con cepas del grupo de microorganismos indicadores evidenció en general una acción microbicida alta. Conclusión: los resultados proporcionan información sobre la carga microbiológica del ambiente que será de utilidad tanto para la comprensión del ingreso y circulación de microorganismos como para la implementación de medidas para prevenir la contaminación microbiana, aspectos críticos en la fabricación de vacunas seguras, puras y eficaces.","palabras_clave":"MONITOREO MICROBIOLÓGICO AMBIENTAL|EFICACIA DE DESINFECTANTES|ASEGURAMIENTO DE CALIDAD|PRODUCCIÓN DE VACUNAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18446,"idioma_id":4,"titulo":"Scorpion sheds 'tail' to escape: consequences and implications of autotomy in scorpions (Buthidae: Ananteris)","resumen":"Autotomy, the voluntary shedding or detachment of a body part at a determined cleavageplane, is a common anti-predation defense mechanism in several animal taxa, including arthropods.Among arachnids, autotomy has been observed in harvestmen, mites, and spiders,always involving the loss of legs. Autotomy of the opisthosoma (abdomen) wasrecently reported in a single species of the Neotropical buthid scorpion genus AnanterisThorell, 1891, but few details were revealed. Based on observations in the field and laboratory,examination of material in museum collections, and scanning electron microscopy, wedocument autotomy of the metasoma (the hind part of the opisthosoma, or ?tail?) in fourteenspecies of Ananteris. Autotomy is more common in males than females, and has not beenobserved in juveniles. When the scorpion is held by the metasoma, it is voluntarily severedat the joints between metasomal segments I and II, II and III, or III and IV, allowing the scorpionto escape. After detachment, the severed metasoma moves (twitches) automatically,much like the severed tail of a lizard or the severed leg of a spider, and reacts to contact,even attempting to sting. The severed surface heals rapidly, scar tissue forming in fivedays. The lost metasomal segments and telson cannot be regenerated. Autotomy of themetasoma and telson results in permanent loss of the posterior part of the scorpion?s digestivesystem (the anus is situated posteriorly on metasomal segment V) and the ability to injectvenom by stinging. After autotomy, scorpions do not defecate and can only capturesmall prey items. However, males can survive and mate successfully for up to eight monthsin the laboratory. In spite of diminished predation ability after autotomy, survival allowsmales to reproduce. Autotomy in Ananteris therefore appears to be an effective, adaptive,anti-predation escape mechanism.","palabras_clave":"SCORPIONES|ANANTERIS|AUTOTOMY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18447,"idioma_id":4,"titulo":"6-Methoxyflavonoids and Other Constituents from Microlialum polymnioides (Asteraceae)","resumen":"The South American genus Microliabum Cabrera (Asteraceae,  Liabeae) comprises 6 species, Microliabum candidum (Griseb.) H.  Rob., Microliabum eremophilum (Cabrera) H. Rob., Microliabum  glanduliferum (Cabrera) H. Rob., Microliabum humile (Cabrera)  Cabrera, Microliabum mulgediifolium (Muschl.) H. Rob., and  Microliabum polymnioides (R. E. Fries) H. Rob. [1]. Microliabum  ocurrs from central Bolivia to central Argentina [2]. Early studies  on the chemical constituents of genus Microliabum revealed the  presence of sesquiterpene lactones [3a-b], flavonoids [4] and  scopoletin [3a]. However, a recent systematic revision of the genus  Microliabum [5a-b] has shown that the population identified as M.  polymnioides in the previous work [3a] belongs to M.  mulgediifolium.  In the course of a chemotaxonomic investigation of species of the  tribe Liabeae we have examined the leaves and flower heads of a  sample of M. polymnioides growing in Salta Province, Argentina.  Chromatographic separation of the ethanol extract of the flower  heads of M. polymnioides afforded, in addition to scopoletin  (7-hydroxy-6-methoxychromen-2-one) 1, the flavonoids 5,4´-  dihydroxy-3,6,7-trimethoxyflavone 2, 3,5,4´-trihydroxy-6,7-  dimethoxyflavone 3 and 3,5,7,4´-tetrahydroxy-6-methoxyflavone 4.  Scopoletin 1 [6] and 3,5,7,4´-tetrahydroxy-6-methoxyflavone 4 [7],  were identified by comparing their spectral properties with those  reported in literature. The structures of compounds 2 and 3 were  established on the basis of 1D NMR (1H NMR, 13C NMR), 2D  NMR (1H-1H COSY, HSQC, HMBC) and HR-ESI-MS. 1H NMR  and 13C NMR data in Me2CO-d6 of compounds 2 and 3 (Table 1)  are also reported here, as the previous data are different, since the  spectra were measured in CDCl3 [8,9].  Investigation into the leaves of M. polymnioides also led to the  characterization of hexadecanoic acid 5, phytol 6 and docosane 7.  This is the first report describing the presence of compounds 2-7 in  the genera Microliabum. So far, flavonoids with 6-methoxy  substitution in the A-rings have not been reported in this genus. The  presence of 6-methoxyflavonoids in M. polymnioides deserves  special chemotaxonomic attention.","palabras_clave":"ASTERACEA |PRODUCTOS NATURALES|METHOXYFLAVONOIDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18448,"idioma_id":4,"titulo":"The Alternative States of Shallow Lakes Model and Zoo-plankton Dynamics in a Temporary Subsaline Ecosystem in Central Argentina in the Absence of Predation by Fish","resumen":"In  La Pampa, there are many subsaline lakes. At present, they have been more  studied some influenced by cities because they have fish that give them  economic and touristic interest. Conversely, the ecology of subsaline lakes not  influenced by cities has not received much attention. Because the predictions  of the alternative states of shallow lakes model have been tested in subsaline  lakes with fish fauna but not in those without fish, the aim of this work is to  analyze information collected in a pampean low salinity lake on the  macrozooplankton richness and its variations in density and biomass along an  annual cycle and to test the following hypotheses: i) due to the lack of  predatory fish, macrozooplankton is dominated by large size species, ii) zooplankton grazing causes that water transparency is  higher than that of pampean lakes with fish, and iii) because of the  presence of large species, macro-zooplankton biomass is higher than that of  lakes with fish. The macrozooplankton richness of Padre Buodo was high (8  cladocerans and 4 copepods). The absence of predation allowed the presence of  large species, especially Daphnia  spinulata, Boeckella gracilis and  Ceriodaphnia dubia and the water  transparency was much higher than in pampean subsaline lakes with fish. While  the total density showed a strong spring peak (667.74 ind.L-1) due  to C. dubia in particular, the higher  biomass (9366.67 µg.L-1) was registered in January, due to D. spinulata. The macrozooplankton  biomass of Padre Buodo was higher than that of subsaline lakes with predatory  fish, especially due to the contribution of cladocerans. The results confirm  the validity of the alternative states model for aquatic ecosystems of La Pampa  with low salts concentrations and a lack of vertebrate predators, and highlight  the role of the top-down effect as a structuring factor of the zooplankton  community","palabras_clave":"Zooplankton|Alternative states of shallow lakes|Daphnia spinulata|Subsaline lakes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18449,"idioma_id":5,"titulo":"Brote de shigelosis en la ciudad de Luján, Argentina","resumen":"El objetivo del estudio fue describir un brote por Shigella sonnei ocurrido en julio  de 2012 en Luján, Buenos Aires, Argentina. Estuvieron afectadas 5 personas que asistieron a una reunión familiar, donde consumieron una rosca vienesa de elaboración artesanal adquirida en un comercio. Todos presentaron fiebre, dolores articulares, escalofríos y diarrea no sanguinolenta con mucus. Se realizaron coprocultivos en los afectados y análisis microbiológicos de los ingredientes. Se aisló y caracterizó S. sonnei de todos los pacientes y de la crema de almendras  empleada en la preparación de la rosca vienesa. A los aislamientos se les determinó el perfil de sensibilidad a los antimicrobianos y el genético por electroforesis en campo pulsado. Los resultados demostraron la relación genética de los aislamientos, y esto confirmó la ocurrencia de los casos por exposición a una misma fuente de infección, la crema de almendras. Al ser un ingrediente industrial, de improbable contaminación inicial, la crema de almendras podría haber sufrido una contaminación durante la manipulación en la panadería.","palabras_clave":"SHIGELOSIS|SHIGELLA SONNEI|BROTE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18450,"idioma_id":5,"titulo":"Jóvenes, militancia y escuela media","resumen":"El trabajo es una aproximación a las representaciones que tienen jóvenes que presiden Centros de Estudiantes de escuelas medias de la provincia de Buenos Aires y se enmarca en el proyecto de investigación ?Representaciones temporales y prácticas sociales: el cambio social a partir de la intervención en el espacio público? (FPyCS, UNLP, 2011-2014). Relevamientos anteriores indicaban la Marcha de La Noche de los Lápices como lugar de iniciación a prácticas políticas de  los jóvenes, por lo que en esta instancia buscamos, de manera inversa, indagar la relación desde los Centros de Estudiantes con esa y otras prácticas de intervención política.  Para eso, recuperamos la normativa vigente en cuanto a la organización de los Centros de Estudiantes, las relaciones con los otros actores institucionales y su vinculación con la noción del espacio público, los límites entre la institución, el contexto social más amplio y, finalmente, el modo en que conciben dicho espacio.  En este sentido, las relaciones que se establecen en el Centro de Estudiantes exceden los vínculos que propone la escuela, configuran otras representaciones sociales entre esos sujetos que los posicionarán como actores sociales, sujetos de derecho y no solo alumnos con derecho.","palabras_clave":"Jóvenes|Militancia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18451,"idioma_id":5,"titulo":"EL DERECHO HUMANO A LA EDUCACIÓN FÍSICA ADAPTADA","resumen":"El artículo pretende generar aportes, a partir del valor de las adaptaciones edilicias y técnicas, para que todas las personas puedan disfrutar del derecho a una vida saludable.","palabras_clave":"DERECHOS HUMANOS|EDUCACIÓN FÍSICA ADAPTADA|INCLUSIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18452,"idioma_id":4,"titulo":"GAL3ST2 from mammary gland epithelial cells affects differentiation of 3T3-L1 preadipocytes","resumen":"Introduction In the mammary gland, the involution thatoccurs when lactation ends is an important period for cancerdevelopment. We have previously demonstrated stromal?epithelium interactions evaluating conditioned medium ofadipose tissue on breast epithelial metalloproteases activity(Creydt et al., Clin Transl Oncol 15:124?131, 2013). Here,weevaluated the effects of conditioned medium of breast epithelialmammary cells on stromal cells.Materials and methods Conditioned medium from normalmurine mammary gland cell line (NMuMG) andconditioned medium proteins were obtained. Then, theywere evaluated on modulation of adipocyte differentiation,using 3T3-L1 cell line.Results We described, for the first time, that breast epithelialmammary cells could produce the enzyme galactose3-O-sulfotransferase 2 (GAL3ST2). Importantly, GAL3ST2is present in NMMuMG and two human breast cancer celllines, and it is more strongly expressed in more metastatictumors. When 3T3-L1 preadipocyte differentiation wastriggered in the presence of conditioned medium fromNMuMG or GAL3ST2, triglyceride accumulation wasdecreased by 40 % and C\/EBPb expression by 80 % inadipocytes. In addition, the expression of FABP4 (aP2),another marker of adipocyte differentiation, was inhibited by40 % in GAL3ST2-treated cells.Conclusions Taken together, these results suggest thatGAL3ST2 would interfere with normal differentiation of3T3-L1 preadipocytes; raising the possibility that it mayaffect normal differentiation of stromal preadipocytes andbe a link to tumor metastatic capacity.","palabras_clave":"ADIPOCYTES|BREAST MAMMARY GLAND|TRIGLYCERIDES|CANCER|CELL LINES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18453,"idioma_id":4,"titulo":"Smectic block copolymer thin films on corrugated substrates","resumen":"In this work we study equilibrium and non-equilibrium structures of smectic block copolymer thin films deposited on a topographically patterned substrate. A Brazovskii free energy model is employed to analyze the coupling between the smectic texture and the local mean curvature of the substrate. The substrate´s curvature produces out-of-plane deformations of the block copolymer such that equilibrium textures are modified and dictated by the underlying geometry. For weak curvatures it is shown that the free energy of the block copolymer film follows a Helfrich form, scaling with the square of the meancurvature, with a bending constant dependent on the local pattern orientation. On substrates of varying mean curvature simulations show that topological defects are rapidly expelled from regions with large curvature. These results compare well with available experimental data of poly(styrene)-copoly(ethylene-alt-propylene) smectic thin films.","palabras_clave":"Block Copolymers|Smectic Phase|Curved Substates"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18454,"idioma_id":4,"titulo":"Phase nucleation in curved space","resumen":"Nucleation and growth is the dominant relaxation mechanism driving first-order phase  transitions. In two-dimensional flat systems, nucleation has been applied to a wide range of  problems in physics, chemistry and biology. Here we study nucleation and growth of  two-dimensional phases lying on curved surfaces and show that curvature modifies both  critical sizes of nuclei and paths towards the equilibrium phase. In curved space, nucleation  and growth becomes inherently inhomogeneous and critical nuclei form faster on regions of  positive Gaussian curvature. Substrates of varying shape display complex energy landscapes  with several geometry-induced local minima, where initially propagating nuclei become  stabilized and trapped by the underlying curvature","palabras_clave":"phase separation|nucleation and growth|curved substrates"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18455,"idioma_id":4,"titulo":"Draft Genome Sequence of Empedobacter (Formerly Wautersiella) falsenii comb. nov. Wf282, a Strain Isolated from a Cervical Neck Abscess","resumen":"Empedobacter (formerly Wautersiella) falsenii comb. nov. strain Wf282 was isolated from a cervical neck abscess sample from an 18-year-old female patient. The isolate was resistant to many antibiotics, including meropenem and colistin. The total DNA from the multidrug-resistant E. falsenii comb. nov. Wf282 clinical isolate was sequenced.","palabras_clave":"Genome Assembly"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18456,"idioma_id":5,"titulo":"Lectura y Escritura. Autopercepción del desempeño en estudiantes universitarios.","resumen":"En este trabajo se examina la autopercepción del desempeño en lectura y escritura de estudiantes de Psicología de la UNLP (Argentina). Se inscribe en las investigaciones sobre la ?alfabetización académica? y surge de la preocupación docente sobre la insuficiencia de habilidades lingüísticas académicas de los alumnos y consecuentemente del alto porcentaje de deserción universitaria. En un estudio descriptivo transeccional se examinaron 50 alumnos de 1º año y 40 de 5º a través de un cuestionario diseñado para detectar la presencia\/ausencia de la autopercepción de dificultades, si aparecen el tipo de dificultades detectadas y la atribución causal a las que obedecen. Se identificaron semejanzas\/diferencias en la autopercpción de los participantes en esos dos grupos: los ingresantes perciben mayores dificultades. Se discuten los alcances de esos resultados en relación con las problemáticas abordadas y su importancia en el diseño de estrategias de intervención que favorezcan el desempeño exitoso en los estudios universitarios.","palabras_clave":"AUTOPERCEPCIÓN |LECTURA|ESCRITURA|ALUMNOS UNIVERSITARIOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18457,"idioma_id":5,"titulo":"LA PRODUCCIÓN TEXTIL COMO ACTIVIDAD DOMÉSTICA DE LOS CAZADORES-RECOLECTORES PREHISPÁNICOS EN LA REGIÓN PAMPEANA, ARGENTINA","resumen":"Se discute la producción textil como una práctica tecnológica emergente en las sociedades cazadoras recolectoras del Holoceno tardío en la pampa. Esta actividad formó parte de la vida doméstica de sociedades prehispánicas que expresaron situaciones de diferenciación social y territorialidad en las sierras de Tandilia oriental. En este trabajo se analiza a los torteros de cerámica -pesos para hilado- como la evidencia material que perdura en la región como instrumental de esta tecnología. Se complementa la información arqueológica, con datos etnográficos e históricos sobre textilería de regiones diversas y se propone como hipótesis que la fibra procedente del vellón del guanaco fue la materia prima utilizada para la elaboración textil en la región. Asimismo se considera el uso de instrumentos óseos como agujas y punzones entre las herramientas de uso potencial para el proceso de hilado y la elaboración de tejidos. Planteamos que las fluctuaciones climáticas del Holoceno tardío-final que produjeron la retracción del guanaco en la Pampa Húmeda desde los siglos XV y XVI en adelante, explican la ausencia en ese período de esta fibra para la textilería, actividad que se reanuda en la época de la colonia a partir del uso de lana de oveja.","palabras_clave":"región pampeana|cazadores-recolectores prehispánicos|textileria|Holoceno tardío"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18458,"idioma_id":4,"titulo":"Physiological behaviour of gliotoxigenic Aspergillus fumigatus sensu stricto isolated from maize silage under simulated environmental conditions","resumen":"Environmental conditions play a key role in fungal development. During the silage production process, humidity, oxygen availability and pH vary among lactic-fermentation phases and among different silage sections. The aim of this work was to study the physiological behaviour of gliotoxicogenic Aspergillus fumigatus strains isolated from maize silage under simulated natural physicochemical conditions ? different water activities (aW), temperatures (Tº), pH and oxygen pressure ? on the growth parameters (growth rate and lag phase) and gliotoxin production. The silage was made with the harvested whole maize plant that was chopped and used for trench-type silo fabrication. Water activity and pH of the silage samples were determined. Total fungal counts were performed on Dichloran Rose Bengal Chloramphenicol agar and Dichloran 18% Glycerol agar. The morphological identi&#64257;cation of A. fumigatus was performed with different culture media and at different growth temperature to observe microscopic and macroscopic characteristics. Gliotoxin production by A. fumigatus was determined by HPLC. All strains isolated were morphologically identi&#64257;ed as A. fumigatus. TwoA. fumigatus strains isolated from the silage samples were selected for the ecophysiological study (A. fumigatus sensu stricto RC031 and RC032). The results of this investigation showed that the fungus grows in the simulated natural physicochemical conditions of corn silage and produces gliotoxin. The study of the physiological behaviour of gliotoxigenic A. fumigatus under simulated environmental conditions allowed its behaviour to be predicted in silage and this will in future enable appropriate control strategies to be developed to prevent the spread of this fungus and toxin production that leads to impairment and reduced quality of silage.","palabras_clave":"ASPERGILLUS FUMIGATUS SENSU STRICTO|GLITOXIN|PHYSIOLOGICAL BEHAVIOUR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18459,"idioma_id":4,"titulo":"Dietary consistency of male South American sea lions (Otaria flavescens) in southern Brazil during three decades inferred from stable isotope analysis","resumen":"Marine predators may undergo remarkable dietary changes through time as a result of both anthropogenic and natural changes in the environment, but this variability is often difficult to tackle and seldom incorporated into eco- system models. This paper uses the stable isotope ratios of carbon and nitrogen in skeletal material of South American sea lions from Brazilian scientific collections to investigate whether these animals modified their diet from 1986 to 2009, as reported for other marine predators in the region. Stable isotope ratios indicated that demersal potential prey were always enriched in 13C as compared with pelagic prey.   Accordingly, the absence of any statistically significant correlation between stranding year and the &#948;13C values of adult males indicated no major increase in   the consumption of pelagic prey from 1986 to 2009. Likewise, the results of the mixing model SIAR revealed a mixed diet including pelagic and demersal prey, with a central role for demersal fishes throughout the whole period. Furthermore, SIAR suggested no major changes in the proportion of pelagic and demersal prey in the diet of adult male South American sea lions during the past three decades. Demersal fishes were also rel- evant prey for juvenile South American sea lions during the whole period, but they always consumed a larger proportion of pelagic prey than the   adults did. These results suggest no major changes in the diet of male South American sea lions during the past three decades in southern Brazil, contrary to what has been reported for other to predators in the regions and for the species in northern Patagonia.","palabras_clave":"Otaria flavescens|South American sea lion|diet|stable isotope analysis|Southern Brazil"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18460,"idioma_id":4,"titulo":"Implicit Attitudes and Road Safety Behaviors. The Helmet-Use Case","resumen":"We studied the role of implicit attitudes on road safety behaviors. We also explored the methodological benefits of using implicit measures to complement conventional self-reporting instruments. The results suggest that: (a) implicit attitudes are capable of predicting observed differences in the use of protective devices (helmet use); (b) implicit attitudes correlate with the emotional component of the explicit attitudes (e.g., perception of comfort?discomfort), but appear to be independent of the more cognitive components (e.g., perceived benefits); (c) the emotional component of the explicit attitudes appears to be the major predictor of behavior; and (d) implicit measures seem to be more robust against social desirability biases, while explicit measure are more sensitive to such bias. We conclude that indirect and automatic measures serve as an important complement to conventional direct measures (self-reports) because they provide information on psychological processes that are qualitatively different (implicit) and can also be more robust when it comes to response bias.","palabras_clave":"Implicit attitude|Implicit association test|Road behavior|Protective behavior"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18461,"idioma_id":4,"titulo":"Thermoplastic starch plasticized with alginate-glycerol mixtures: Melt-processing evaluation and film properties","resumen":"tCorn starch melt-processing in the presence of a commonly used plasticizer mixture (water\/glycerol)and a non-conventional alternative (alginate\/glycerol) was evaluated. All assayed formulations weresuccessfully processed by melt-mixing and injected in circular probes. It was determined that all sam-ples presented a typical viscoelastic behavior, observing a decrease in storage and loss modulus withwater and alginate concentration, which facilitated samples processability. Concerning to thermal sta-bility, it was not affected neither for water nor alginate presence. From injected probes, flexible filmswere obtained by thermo-compression. Films with the highest assayed water content presented a stickyappearance, whereas those containing alginate were non-tacky. Plasticizing action of water and alginatewas evidenced by the occurrence of homogeneous fracture surfaces, without the presence of unmeltedstarch granules. Besides, the shift of glass transition temperature to lower values also corroborated theplasticizing effect of both additives. In conclusion, obtained results demonstrated the well-plasticizingaction of sodium alginate on starch matrix, turning this additive into a promissory alternative to replacewater during melt-processing of thermoplastic corn-starch.","palabras_clave":"alginate"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18462,"idioma_id":4,"titulo":"Linearly constrained minimum variance spatial filtering for localization of conductivity changes in electrical impedance tomography","resumen":"We localize dynamic electrical conductivity changes and reconstruct   their time evolution introducing the spatial filtering technique to   electrical impedance tomography (EIT). More precisely, we use the   unit-noise-gain constrained variation of the distortionless-response   linearly constrained minimum variance spatial filter. We address the   effects of interference and the use of zero gain constraints. The   approach is successfully tested in simulated and real tank phantoms. We   compute the position error and resolution to compare the localization   performance of the proposed method with the one-step Gauss?Newton   reconstruction with Laplacian prior. We also study the effects of sensor   position errors. Our results show that EIT spatial filtering is useful   for localizing conductivity changes of relatively small size and for   estimating their time-courses. Some potential dynamic EIT applications   such as acute ischemic stroke detection and neuronal activity   localization may benefit from the higher resolution of spatial filters   as compared to conventional tomographic reconstruction algorithms.","palabras_clave":"ELECTRICAL IMPEDANCE TOMOGRAPHY|SPATIAL FILTERING|LINEARLY CONSTRAINED MINIMUM VARIANCE SPATIAL FILTER|LOCALIZATION OF CONDUCTIVITY CHANGES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18463,"idioma_id":4,"titulo":"Genetic variability and fumonisin production by Fsuarium proliferatum isolated from durum wheat grains in Argentina","resumen":"Fusarium proliferatum is a member of the Fusarium fujikuroi species complex (FFSC) involved in the maize ear rot together with Fusarium verticillioides, which is a very closely related species. Recently, different studies have detected natural fumonisin contamination in wheat kernels and most of them have shown that the main species isolated was F. proliferatum. Fusarium strains obtained from freshly harvested durum wheat samples (2008 to 2011 harvest seasons) from Argentina were characterized through a phylogenetic analysis based on translation elongation factor-1 alpha (EF-1&#945;) and calmodulin (CaM) genes, determination of mating type alleles, and evaluation of fumonisin production capability. The strains were identified as F. proliferatum (72%), F. verticillioides (24%) and other Fusarium species. The ratio of mating type alleles (MAT-1 and MAT-2) obtained for both main populations suggests possible occurrence of sexual reproduction in the wheat fields, although this seems more frequent in F. proliferatum. Phylogenetic analysis revealed greater nucleotide variability in F. proliferatum strains than in F. verticillioides, however this was not related to origin, host or harvest year. The fumonisin-producing ability was detected in 92% of the strains isolated from durum wheat grains. These results indicate that F. proliferatum and F. verticillioides, among the fumonisin producing species, frequently contaminate durum wheat grains in Argentina, presenting a high risk for human and animal health.","palabras_clave":"FUMONISINS|FUSARIUM PROLIFERATUM|FUSARIUM VERTICILLIOIDES|GENETIC VARIABILITY|MAT ALLELES|WHEAT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18464,"idioma_id":5,"titulo":"Evaluación y diagnóstico de los sistemas de producción de carne bovina en el Departamento Rosario, Santa Fe ? 2013-2014","resumen":"Martín, B.; Cechetti, S.; Bernasconi, R.; Acciarri, F. y Pijuan, G. 2015. Evaluación y diagnóstico de los sistemas de producción de carne bovina en el departamento Rosario, Santa Fe. 2013-2014. Agromensaje Edición especial. Marzo 2015. ISSN: 1669-8584","palabras_clave":"sistemas ganaderos|diagnóstico|producción|carne bovina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18465,"idioma_id":5,"titulo":"Impacto del acortamiento en el tiempo de maduración sobre el perfil sensorial de queso de oveja","resumen":"La etapa de maduración o afinado del queso es fundamental para el desarrollo de sus atributos sensoriales (textura, color, aroma, sabor, olor). Por otro  lado representa  una etapa de inmovilización de capital para la empresa.  El objetivo de esta investigación fue evaluar el impacto de disminuir el tiempo de maduración de 35 a 21 días sobre el contenido de sólidos totales y el perfil sensorial de textura y flavor de quesos de leche de oveja. Los quesos fueron elaborados con leche proveniente de la Unidad  Demostrativa Tambo Ovino de la Universidad de Buenos Aires. Se utilizó un diseño de experimento completamente aleatorizado (DCA) con 12 elaboraciones. Los quesos resultantes fueron asignados al azar a los siguientes tratamientos: 35 días de maduración (M35) o 21 días de maduración (M21), efectuada en cámara a 12-15 ºC y 85-90% de humedad relativa. Al finalizar la maduración un panel de evaluadores entrenados determinó el perfil de textura y flavor. Los datos sensoriales obtenidos se analizaron mediante análisis discriminante multivariado, el cual estableció ponderaciones para cada atributo en relación con su aporte a la separación de los tratamientos. Los quesos de 21 días de maduración presentaron mayor elasticidad y humedad en superficie que aquellos madurados durante 35 días. Asimismo, estos últimos fueron descriptos como más picantes y salados, presentaron mayor persistencia y retrogusto y mayor friabilidad de la masa al tacto. Se concluye que existió un impacto del tiempo de maduración sobre algunos descriptores sensoriales de flavor y de textura. Un estudio de consumidores permitiría predecir la conveniencia de liberar a la venta este producto 14 días antes, disminuyendo así la inmovilización de capital de la quesería.","palabras_clave":"QUESOS DE OVEJA|TIEMPO DE MADURACION|FLAVOR|TEXTURA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18466,"idioma_id":4,"titulo":"A new species of Tribonium Saussure, 1862 from the Province of Misiones, Argentina (Blattaria, Blaberidae, Zetoborinae)","resumen":"Tribonium rothi sp. n. is described from Argentina, whereas T. neospectrum and T. conspersum are recorded for the first  time for that country, and their genitalia is redescribed. Femur and tibial spine armature are given and Tribonium is compared  with Schistopeltis. A key to identify species of the genus Tribonium recorded in Argentina is provided.","palabras_clave":"TRIBONIUM ROTHI|GENITALIA|DISTRIBUTION|LEG ARMATURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18467,"idioma_id":4,"titulo":"Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals","resumen":"Transgenic farm animals are attractive alternative mammalian models to rodents for the study of developmental, genetic, reproductive and disease-related biological questions, as well for the production of recombinant proteins, or the assessment of xenotransplants for human patients. Until recently, the ability to generate transgenic farm animals relied on methods of passive transgenesis. In recent years, significant improvements have been made to introduce and apply active techniques of transgenesis and genetic engineering in these species. These new approaches dramatically enhance the ease and speed with which livestock species can be genetically modified, and allow to performing precise genetic modifications. This paper provides a synopsis of enzyme-mediated genetic engineering in livestock species covering the early attempts employing naturally occurring DNA-modifying proteins to recent approaches working with tailored enzymatic systems.","palabras_clave":"Active transgenesis|Livestock|Binary transposon system|Designer nuclease"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18468,"idioma_id":4,"titulo":"MOLECULAR SCREENING OF PATHOGENIC ESCHERICHIA COLI ISOLATED FROM DAIRY NEONATAL CALVES IN CORDOBA PROVINCE, ARGENTINA","resumen":"The aim of this study was to perform a current molecular characterization of bovine pathogenic Escherichia coli strains isolated from random samplings in Argentinean dairy farms. Rectal swabs were obtained from 395 (63.7 %) healthy and 225 (36.3 %) diarrheic calves, belong-ing to 45 dairy farms in Cordoba Province, Argentina. E. coli isolates were examined for virulence genes (f5, f41, f17, sta, stb, lt, eae, vt) using PCR and the prevalence of E. coli virulence pro-files was spatially described in terms of spatial distribution. A total of 30.1 % isolates were found to be positive for at least one of the virulence genes. Depending on the different gene combinations present, 11 virulence profiles were found. Most of the isolates analyzed had a single gene, and no combination of fimbrial and enterotoxin gene was predominant. There was no association between the frequency and distribution of E. coli virulence genes and calf health status. Most of the virulence profiles were compatible with ETEC strains and showed a homo-geneous distribution over the sampled area. A clustering pattern for E. coli virulence profiles could not be recognized. This work provides updated information on the molecular characteri-zation of pathogenic E. coli strains from dairy herds in Cordoba, Argentina. These findings would be important to formulate prevention programs and effective therapies for diarrhea in calves caused by E. coli.","palabras_clave":"ESCHERICHIA COLI|CALVES|DIARRHEA|PCR|VIRULENCE GENES|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18469,"idioma_id":4,"titulo":"PD-like controller with impedance for delayed bilateral teleoperation of mobile robots","resumen":"This paper proposes a control scheme applied to the delayed bilateralteleoperation of mobile robots with force feedback in face of asymmetric and time-varying delays. The scheme is managed by a velocity PD-like control plus impedance and a force feedback based on damping and synchronization error. A fictitious force, depending on the robot motion and its environment, is used to avoid possible collisions. In addition, the stability of the system is analyzed from which simple conditions for the control parameters are established in order to assure stability. Finally, the performance of the delayed teleoperation system is shown through experiments where a human operator drives a mobile robot.","palabras_clave":"Teleoperation|Mobile Robots|Haptic Interfaces|Robot Dynamics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18471,"idioma_id":5,"titulo":"Presas y sitios de capturas utilizados por arañas cangrejo (Araneae: Thomisidae y Philodromidae) en un pastizal del centro de Argentina","resumen":"      La distribución de los depredadores y flores son importantes factores  que influyen sobre la elección del sitio de forrajeo por los visitantes  florales. Los depredadores como las arañas cangrejo pueden determinar la  estructura de las comunidades de visitantes florales e influir sobre la  polinización de las plantas. Investigamos diferentes aspectos de la biología de  las arañas cangrejo relacionados con sus sitios de captura y sus presas. Los  objetivos del estudio fueron (a) evaluar el uso por las arañas cangrejo de  flores o inflorescencias (en adelante unidades de atracción floral, UAF) como  sitios de captura; (b) determinar características que pueden afectar el uso de  los sitios de captura; y (c) evaluar la relación entre el tamaño de las arañas  y el de sus presas. Recorrimos dos parcelas de una hectárea en el centro de la  región Pampeana (Buenos Aires, Argentina) registrando todas las plantas  entomófilas en flor y sus visitantes florales. Además, capturamos todas las  arañas cangrejo con y sin presa registrando las UAF que utilizaron como sitio  de captura. Medimos y evaluamos la relación entre el tamaño de las arañas y de  sus presas. Las arañas cangrejo utilizaron como sitios de captura las UAF más  abundantes y con mayor riqueza de visitantes florales, independientemente si  eran flores o inflorescencias. Por otro lado, el tamaño de la araña podría  estar determinando el tamaño de su presa. Encontramos una asociación positiva  entre ambas variables, aunque este resultado fue variable dependiendo de los  órdenes taxonómicos de las presa. Estos resultados sugieren que las arañas  cangrejo pueden tener un papel relevante modelando la estructura de las  interacciones planta-polinizadores.    ","palabras_clave":"POLLINATOR|TRIPLE INTERACTION|FLORAL VISITOR|PAMPAS REGION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18473,"idioma_id":4,"titulo":"Biocatalytic synthesis, antimicrobial properties and toxicity studies of arginine derivative surfactants","resumen":"Two novel arginine-based cationic surfactants were synthesized using as biocatalyst papain, an endopeptidase from Carica papaya latex, adsorbed onto polyamide.  The classical substrate N&#945;-benzoyl-arginine ethyl ester hydrochloride (BAEE) for the determination of cysteine and serine proteases activity was used as the arginine donor, whereas decyl- and dodecylamine were used as nucleophiles for the condensation reaction. Yields higher than 90 and 80% were achieved for the synthesis of   N&#945;-benzoyl-arginine decyl amide (Bz-Arg-NHC10) and N&#945;-benzoyl-arginine dodecyl amide (Bz-Arg-NHC12) respectively. The purification process was developed in order to make it more sustainable, by using water and ethanol as the main separation solvents in a single cationic exchange chromatographic separation step. Bz-Arg-NHC10 and   Bz-Arg-NHC12 proved antimicrobial activity against both Gram-positive and Gram-negative bacteria, revealing their potential use as effective disinfectants as they reduced 99% the initial bacterial population after only one hour of contact. The cytotoxic effect towards different cell types of both arginine derivatives was also measured.   Bz-Arg-NHCn demonstrated lower haemolytic activity and were less eye-irritating than the commercial cationic surfactant cetrimide. A similar trend could also be observed when cytotoxicity was tested on hepatocytes and fibroblasts cell lines: both arginine derivatives were less toxic than cetrimide. All these properties would make the two novel arginine compounds a promising alternative to commercial cationic surfactants, especially for their use as additives in topical formulations.","palabras_clave":"Arginine based surfactants|Papain|Biocatalysis|Antimicrobial activity|Cytotoxic effect"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18474,"idioma_id":4,"titulo":"Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition","resumen":"Cells make accurate decisions in the face of molecular noise and environmental fluctuations by relying not only on present pathway activity, but also on their memory of past signaling dynamics. Once a decision is made, cellular transitions are often rapid and switch-like due to positive feedback loops in the regulatory network. While positive feedback loops are good at promoting switch-like transitions, they are not expected to retain information to inform subsequent decisions. However, this expectation is based on our current understanding of network motifs that accounts for temporal, but not spatial, dynamics. Here, we show how spatial organization of the feedback-driven yeast G1\/S switch enables the transmission of memory of past pheromone exposure across this transition. We expect this to be one of many examples where the exquisite spatial organization of the eukaryotic cell enables previously well-characterized network motifs to perform new and unexpected signal processing functions.","palabras_clave":"Compartmentalization |pheromone|Far1|intergenerational memory"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18475,"idioma_id":4,"titulo":"Four chromophores in one building block: synthesis, structure and characterization of trans-[Ru(MQ)4Cl2]4+ and trans-[Ru(4,4'-bpy)4Cl2] (MQ+ = N-methyl-4,4'-bipyridinium, bpy = bipyridine)","resumen":"We report the synthesis, crystallographic structure, electrochemical and spectroscopic properties of the complex trans-[Ru(MQ)4Cl2]4+ (14+), where MQ+ = N-methyl-4,4?-bipyridinium. The crystal structure of 14+ shows the pyridinic rings bound in a trans fashion to the Ru ion. In 14+ and in its analogue trans-[Ru(4,4?-bpy)4Cl2] (2, bpy = bipyridine), the electrochemical reduction waves of the four iminic ligands occur at very closely spaced potentials. 14+ and 2 present high molar extinction coefficients in acetonitrile (&#949; = 20000-50000 M-1cm-1) and absorptions that are red-shifted (up to 800 nm for 14+ and up to 600 nm for 2) relative to previously reported analogues. Upon protonation of the four exposed nitrogen atoms of 2 and electrochemical reduction of the ligands in 14+ and 2, spectral changes occur with retention of isosbestic points, revealing the presence of four independent chromophores. Together these results suggest poor electronic communication between the aromatic ligands within each compound, in clear contrast to what happens with related complexes such as cis-[Ru(2,2?-bpy)2Cl2] (3).","palabras_clave":"Ruthenium tetrapyridine |N-methyl-4,4-bipyridinium |Supramolecular building block|Red sensitization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18476,"idioma_id":5,"titulo":"Los ácidos biliares y su relación con la análisis de concentración de colesterol total, triglicéridos y glucosa en el perro con Síndrome de Cushing.","resumen":"El S¨ªndrome de Cushing suele cursar con dislipemia provocada por el aumento del colesterol y los triglic¨¦ridos circulantes. Los ¨¢cidos biliares son sintetizados en el h¨ªgado a partir del colesterol y est¨¢n relacionados con el control de las v¨ªas metab¨®licas de l¨ªpidos y glucosa. Se estudiaron los ¨¢cidos biliares (ayuno y postprandiales), colesterol, triglic¨¦ridos y glucemia en 15 perros con S¨ªndrome de Cushing. Las concentraciones de ¨¢cidos biliares en ayuno se hallaron elevados (&gt;25¦Ìmol\/L) en 3\/15 perros y cercanos al l¨ªmite de corte (20-25¦Ìmol) en 8\/15, estando correlacionados con el cortisol (r=0,62; P=0,014); colesterol (r=0,66; P=0,007) y triglic¨¦ridos (r=0,60, P=0,017). La concentraci¨®n posprandial de ¨¢cidos biliares fue &gt;50¦Ìmol\/L en los 15 animales. Por ultrasonograf¨ªa, en 9\/15 perros hab¨ªa barro biliar y en la totalidad hepatomegalia con imagen compatible con esteatosis. Se concluye que en el S¨ªndrome de Cushing los ¨¢cidos biliares est¨¢n relacionados con las concentraciones de cortisol, colesterol y triglic¨¦ridos. Por otra parte, los ¨¢cidos biliares podr¨ªan jugar un papel en el mantenimiento de altas concentraciones de cortisol y en mantener activada la v¨ªa metab¨®lica de los l¨ªpidos.","palabras_clave":"Acidos biliares|dislipemia|Cushing|Perro"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18477,"idioma_id":5,"titulo":"Influencia de las estructuras arqueológicas en la abundancia y distribución de la vegetación y características del suelo en Ampimpa. Tucumán, Argentina.","resumen":"La localidad de Ampimpa, se encuentra en el departamento de Tafí del Valle, Tucumán, Argentina, ubicada en el sector pedemontano de Cumbres Calchaquíes, en el valle de Santa María. Esta zona presenta numerosos asentamientos prehispánicos rodeados por un arbustal xerófito característico de la Ecorregión del Monte. El objetivo del trabajo fue evaluar la influencia que ejercen las estructuras arqueológicas presentes sobre la distribución de la vegetación y sobre las características del suelo. Para ello se muestreó la vegetación asociada a dichas estructuras (terrazas y recintos circulares) y la vegetación no vinculada a las mismas. Se determinó la abundancia relativa y la diversidad de especies (mediante el Índice de Shannon-Wiener) en ambas situaciones, posteriormente se aplicó un análisis de la varianza paramétrico (ANOVA), para evaluar si existen diferencias significativas en cuanto a la composición de especies. Se evaluaron ciertos parámetros del suelo (textura, pH, materia orgánica, fósforo orgánico, fósforo disponible y contenido de calcio) para determinar si la presencia de dichas estructuras modifica al sustrato circundante.    Este estudio aportó una metodología para el muestreo de vegetación asociada a estructuras arqueológicas y evidencias de cómo la presencia de dichas estructuras ejerce control sobre el sustrato y por lo tanto sobre la vegetación asociada al mismo.","palabras_clave":"Asentamientos prehispánicos|Estructuras arqueológicas|Especies vegetales Indicadoras|Valles Calchaquíes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18478,"idioma_id":4,"titulo":"SOM+PSO. A Novel Method to Obtain Classification Rules","resumen":"Currently, most processes have a volume of historical information that makes its manual processing difficult. Data mining, one of the most significant stages in the Knowledge Discovery in Databases (KDD) process, has a set of techniques capable of modeling and summarizing these historical data, making it easier to understand them and helping the decision making process in future situations. This article presents a new data mining adaptive technique called SOM+PSO that can build, from the available information, a reduced set of simple classification rules from which the most significant relations between the features recorded can be derived. These rules operate both on numeric and nominal attributes, and they are built by combining a variation of a population metaheuristic and a competitive neural network. The method proposed was compared with the PART method and measured over 19 databases (mostly from the UCI repository), and satisfactory results were obtained.","palabras_clave":"Classification Rules|Data Mining|Adaptive Strategies|Particle Swarm Optimization| Self-Organizing Maps"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18479,"idioma_id":4,"titulo":"Physico-chemical characteristics and pyrolysis behavior of Klason lignins isolated from agro-industrial biomass","resumen":"Klason lignins lab-isolated from two lignocellulosic biomasses emerging from the processing of agro-industrial products, Aspidosperma australe wood sawdust and Bertholletia excelsa nutshells, with different contents of lignin (27 and 57 wt%, respectively) are characterized. Characterization includes determination of ash content, elemental composition, Fouriertrans form infrared spectra, and surface morphological features by scanning electronic microscopy. Pyrolysis behavior of the isolated lignins as well as of the parent biomasses from which they are extracted is comparatively examined by non-isothermal thermogravimetric analysis from room temperature up to 1000 ºC. The lignins exhibit different ash contents and elemental compositions, as well as noticeable differences in their pyrolytic behavior depending on the botanical origin of the bio-resource and with respect to that determined for the untreated parent biomasses. Overall, the lignin isolated from the nutshells is more resistant to degrade than the sawdust-derived lignin likely due to a more condensed chemical structureAspidosperma australe wood sawdust and Bertholletia excelsa nutshells, with different contents of lignin (27 and 57 wt%, respectively) are characterized. Characterization includes determination of ash content, elemental composition, Fouriertrans form infrared spectra, and surface morphological features by scanning electronic microscopy. Pyrolysis behavior of the isolated lignins as well as of the parent biomasses from which they are extracted is comparatively examined by non-isothermal thermogravimetric analysis from room temperature up to 1000 ºC. The lignins exhibit different ash contents and elemental compositions, as well as noticeable differences in their pyrolytic behavior depending on the botanical origin of the bio-resource and with respect to that determined for the untreated parent biomasses. Overall, the lignin isolated from the nutshells is more resistant to degrade than the sawdust-derived lignin likely due to a more condensed chemical structure","palabras_clave":"KLASON LIGNINS|PYROLYSIS|BIOMASS|BIO-ENERGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18480,"idioma_id":4,"titulo":"Modeling the biosorption of basic dyes from binary mixtures","resumen":"The biosorption of basic dyes, methylene blue and rhodamine B, from binary aqueous solutions onto cypress cone chips, was analyzed through mathematical modeling. This study aimed at introducing a novel model to predict the dynamic binary sorption of the dyes. It consisted of a modified Langmuir multicomponent isotherm coupled with a linear driving force model. Experimental data from recent studies using the untreated and alkaline-treated biosorbent was used to determine the model parameters, and the breakthrough predictions are in good agreement with the experimental results. Useful information on the effects of bed length and feed concentration on the breakthrough time and mass transfer length was obtained. This can guide the design and optimization of the biosorbent column.","palabras_clave":"BIOSORPTION|BASIC DYES|DYNAMIC STUDIES|MODELING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18481,"idioma_id":4,"titulo":"Development and characterization of activated hydrochars from orange peels as potential adsorbents for emerging organic contaminants","resumen":"Activated hydrochars obtained from the hydrothermal carbonization of orange peels (Citrus sinensis) followed by various thermochemical processing were assessed as adsorbents for emerging contaminants in water. Thermal activation under flows of CO2 or air as well as chemical activation with phosphoric acid were applied to the hydrochars. Their characteristics were analyzed and related to their ability to uptake three pharmaceuticals (diclofenac sodium, salicylic acid and flurbiprofen) considered as emerging contaminants. The hydrothermal carbonization and subsequent activations promoted substantial chemical transformations which affected the surface properties of the activated hydrochars; they exhibited specific surface areas ranging from 300 to 620 m2\/g. Morphological characterization showed the development of coral-like microspheres dominating the surface of most hydrochars. Their ability to adsorb the three pharmaceuticals selected was found largely dependent on whether the molecules were ionized or in their neutral form and on the porosity developed by the new adsorbents.","palabras_clave":"ACTIVATED HYDROCHARS|EMERGING CONTAMINANTS|HYDROTHERMAL CARBONIZATION|ORANGE PEELS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18482,"idioma_id":4,"titulo":"Copyrolysis of peanut shells and cassava starch mixtures: effect of the components proportion","resumen":"Copyrolysis of peanut (Arachis hypogaea) shells and cassava (Manihot esculenta) starch using mixtures of different proportions was examined to improve yield of the bio-oil and its quality. Pyrolysis of the individual components was also investigated in order to quantify the improvement of the measured properties. The kinetics of pyrolysis\/copyrolysis was characterized by thermogravimetrical analysis and the application of two different models: one which takes into account the deactivation of the solid, and another one which assumes a normal distribution of the activation energy. Interactions between the starch and the shells were inferred since maximum reaction rates were, in all cases, lower than the weighed average values obtained for the pyrolysis of the individual components. Furthermore, both the bio-oil yield and the water content of the liquids showed synergistic effects. A mixture composed by 75 wt% of starch and 25 wt% of peanut shells led to maximize the yield of the bio-oil (58.2 wt%), while its water content was reduced in 3.4% in comparison with the value expected from the weighed average of the individual results. On the other hand, the addition of the starch to the peanut shells led to a bio-char with less ash content. It could be more suitable for further combustion in steam boilers.","palabras_clave":"COPYROLYSYS|PEANUT SHELL|CASSAVA STARCH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18483,"idioma_id":4,"titulo":"Preprocessing Unbalanced Data Set Based on Self-organizing Neural Networks","resumen":"The unbalanced of data is a common problem in many domains. Using unbalanced data for standard machine learning classifiers significantly affect the obtained performance. In this paper is presented a description of the problem and a review of the main alternatives to solve it. It is also proposed an alternative model, illustrating its application through a case of the medical field. The proposed model manages to get a balanced distribution of instances per class. It is based on the automatic selection of a subset of cases from the majority classes, using the natural groupings of these classes through self-organizing maps. The model is applied to the recognition of heartbeat types and the results are compared with others methods. The results show the feasibility of using this model to address this problem.","palabras_clave":"unbalanced data|data resampling|self organizing maps|support vector machines"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18484,"idioma_id":4,"titulo":"Temporal Comparison of Arrhythmia States Sequence","resumen":"This paper describe a monitoring model for intelligent systems in the assessment tasks of patient?s critical states. The model was designed according to temporal abstraction dimensions and state interpretation levels, particularly the monitored physiological state. Monitoring arrhythmias was used as the reference case for model development. This model is based on the Smith-Waterman algorithm, with a modified substitution matrix. It was developed for the state space assessment model, for said application. Matrix modification was oriented for giving more influence to the principal state for the temporal pattern represented. The performance of the state interpretation model was similar than other models reported in the literature. The state space assessment model allow to get extra temporal information about a possible evolution, not previously available in classic monitors.","palabras_clave":"temporal comparison|arrhythmia states|sequence"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18485,"idioma_id":5,"titulo":"Paisajes rurales de Argentina y Chile. Posibilidades para el turismo rural","resumen":"Las modificaciones y transformaciones experimentadas en los diferentes paisajes  rurales de los países de América Latina, influidas en gran medida por los efectos e  impactos positivos y negativos derivados del proceso de globalización de nuestras  economías, se traduce en la existencia de áreas ganadoras y perdedoras en las  cuales es necesario realizar los diagnósticos a partir de los cuales los geógrafos,  agronómos y otros especialistas en ciencias de la tierra, puedan posteriormente  sugerir planes de desarrollo local rural, a fin de mitigar los efectos directos sobre la población de las regiones perdedoras.  En este contexto la agenda panamericana del IPGH, se constituye en una alternativa  para orientar los esfuerzos de investigación de los diferentes grupos de especialistas  que están trabajando en ordenamiento territorial y elaboración de planes de desarrollo local, con la finalidad de contribuir a la sustentabilidad de los tradicionales paisajes rurales y evidentemente orientar a los habitantes de dichas áreas hacia la búsqueda de alternativas para alcanzar un desarrollo más pleno.  Este proyecto se propone evaluar las transformaciones de paisajes seleccionados de  Argentina y Chile, a fin de establecer la factibilidad de utilizar los recursos paisajísticos y patrimonio cultural en la definición de alternativas para implementar actividades de turismo rural. Se busca evaluar la existencia de potencialidades para ello, así como la disposición de la población y autoridades territoriales, para apoyar iniciativas que incentiven la existencia de rutas de agroturismo en cada una de las áreas de estudio que han sido seleccionadas por los equipos de investigación de ambos países","palabras_clave":"Globalización|Degradación del ambiente|alternativas|Turismo rural"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18486,"idioma_id":4,"titulo":"New Synthesis and Biological Evaluation of Benzothiazole Derivates as Antifungal Agents","resumen":"ABSTRACT: In search of new antifungal agrochemicals that could replace commercially available, aryl-2-mercaptobenzothiazoles were synthesized. They were prepared by two methodologies, using both photostimulated reaction and microwave assisted reaction. These reactions took place without the use of metallic catalyst by a one-pot procedure with excellent yields (70&#8722;98%).  Synthesized compounds were evaluated for fungal growth inhibition against Botrytis cinerea. Most of the compounds have an excellent antifungal activity, and three of these showed a superior inhibitory e&#64256;ect to commercial fungicide Triadimefon. IC50 values observed for 2-(phenylthio)benzothiazole, 2-(2-chlorophenylthio) benzothiazole, and 2-(3-chlorophenyl thio)benzothiazole were 0.75, 0.69, and 0.65 &#956;gmL&#8722;1, respectively.","palabras_clave":"Synthesis|Antifungal activities|Botrytis cinerea|Microwave irradiation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18487,"idioma_id":4,"titulo":"Intramolecular sulfonylamidomethylation of 2-(2-naphthyl) and 2-(1-naphthyl)ethanesulfonamides: synthesis of new class of naphthosultams","resumen":"New 1,2,4,5-tetrahydronaphtho[1,2-d]3,2-thiazepine 3,3-dioxides and 1,2,4,5-  tetrahydronaphtho[2,1-d]3,4-thiazepine 3,3-dioxides were synthesized by aromatic  intramolecular sulfonylamidomethylation of 2-(2-naphthyl) and 2-(1-   naphthyl)ethanesulfonamides with s-trioxane using Amberlyst XN-1010 as catalyst in excellent yields and with high regioselectivity.","palabras_clave":"Naphthothiazepines|Heterogeneous catalysis|Cyclization reactions|Amberlyst XN-1010"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18488,"idioma_id":4,"titulo":"Kinetics of the gas-phase reaction between ozone and three unsaturated oxygenated compounds: ethyl 3,3-dimethyl acrylate, 2-methyl-2-pentenal and 6-methyl-5-hepten-2-one at atmospheric pressure","resumen":"Rate coefficients for the gas-phase reactions of O3 molecules with three unsaturated oxygenated compounds have been determined using the relative kinetic technique in an environmental chamber with FTIR detection of the reactants at (298 ± 2) K in 760 Torr total pressure of synthetic air. The following rate coefficients (in units of 10\u000317 cm3 molecule\u00031 s\u00031) were determined: ethyl 3,3-dimethyl acrylate (0.82 ± 0.19), 2-methyl-2-pentenal (0.71 ± 0.16) and 6-methyl-5-hepten-2-one (26 ± 7).The different reactivity of the unsaturated oxygenated compounds toward O3 is discussed in terms of their chemical structure. In addition, a correlation between the reactivity of structurally different unsaturatedcompounds (alkenes and unsaturated oxygenated VOCs, such as ethers, esters, aldehydes,ketones and alcohols) toward O3 molecules and the HOMO (Highest Occupied Molecular Orbital) of the compounds is presented.Using the kinetic parameters determined in this work, residence times of these unsaturated compounds in the atmosphere with respect to reaction with O3 have been calculated. In urban and rural areas the main sink of 6-methyl-5-hepten-2-one is reaction with O3 molecules with a residence time in the order of few minutes.","palabras_clave":"BVOC|UNSATURATED CARBONYLS|FTIR|BIG PHOTOREACTORS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18489,"idioma_id":4,"titulo":"Ozonolysis of a series of C7-C9 unsaturated biogenic aldehydes: reactivity study at atmospheric pressure","resumen":"Rate coefficients for the reactions of ozone with the biogenic aldehydes trans-2-heptenal, trans-2-octenal and trans-2-nonenal have been determined at 298 K and (990 +\/- 10) mbar of pressure in air in an environmental chamber using in situ FTIR spectroscopy to monitor the reactants. The following rate coefficients in units of kO3 &#61620; 1018 (cm3\/molecule-1 s-1) were obtained: (2.47 ± 0.73) for trans-2-heptenal, (2.37 ± 0.68) for trans-2-octenal and (2.05 ± 0.20) for trans-2-nonenal.   It is shown that rate coefficients for the addition of O3 molecules and OH radicals to the double bond of alkenes and unsaturated and oxygenated volatile organic compounds (OVOCs) at 298 K are related to a good approximation by the expression: log kOH = 0.16 log kO3 - 7.55. Furthermore, a correlation between the reactivity of unsaturated VOCs toward O3 molecules and the energies of the Highest Occupied Molecular Orbit (HOMO) of the unsaturated VOCs is presented and potential atmospheric implications of the results are discussed.","palabras_clave":"ALDEHYDES|SMOG CHAMBERS|OZONOLYSIS|FREE ENERGY RELATIONSHIPS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18490,"idioma_id":4,"titulo":"Interleukin-1beta-induced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and alpha-melanocyte-stimulating hormone prevented these effects","resumen":"The immune system is an important modulator of learning, memory and   neural plasticity. Interleukin 1beta (IL-1b), a pro-inflammatory cytokine,   significantly affects several cognitive processes. Previous studies by   our group have demonstrated that intrahippocampal administration of   IL-1b impairs reconsolidation of contextual fear memory. This effect was   reversed by the melanocortin alpha-melanocyte-stimulating hormone   (a-MSH). The mechanisms underlying the effect of IL-1b on memory   reconsolidation have not yet been established. Therefore, we examined   the effect of IL-1b on glutamate release, ERK phosphorylation and the   activation of the transcription factor zinc finger- 268 (zif268) during   reconsolidation. Our results demonstrated that IL-1b induced a   significant decrease of glutamate release after reactivation of the fear   memory and this effect was related to calcium concentration in   hippocampal synaptosomes. IL-1b also reduced ERK phosphorylation and   zif268 expression in the hippocampus. Central administration of a-MSH   prevented the decrease in glutamate release, ERK phosphorylation and   zif268 expression induced by IL-1b. Our results establish possible   mechanisms involved in the detrimental effect of IL-1b on memory   reconsolidation and also indicate that a-MSH may exert a beneficial   modulatory role in preventing IL-1b effects.","palabras_clave":"IL-1BETA|ALPHA-MSH|MEMORY RECONSOLIDATION|GLUTAMATE RELEASE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18491,"idioma_id":4,"titulo":"Biochemical composition and protein profile of alpaca (Vicugna pacos) oviductal fluid","resumen":"Knowledge and assessment of the constituents of the oviductal fluid (OF) in camelids  is necessary for a correct formulation of specific culture media for the development of  reproductive biotechnology. This study is the first describing the biochemical composition  and SDS-PAGE protein profile of alpaca oviductal fluid in non-pregnant animals and animals  that have completed the first month and second month of gestation. Samples were  also classified into oviducts that were ipsilateral or contralateral to the ovary with corpus  luteum. No differences were found between both oviducts, whereas pregnant and non-pregnant females displayed significant differences in the biochemical composition  and protein profile of the oviductal fluid. Relative albumin content was higher in nonpregnant  females. Relative creatinine content in OF from females that have completed the  second month of gestation was lower than non-pregnant females and females that have  completed the first month of gestation. Ion Na+ concentration was higher in OF from nonpregnant  females when compared with pregnant ones. The protein profile of non-pregnant  females showed five protein bands of 70, 42, 25, 24 and 19 kDa that were significantly  more intense compared with pregnant animals. Bands were identified as moesin, actin  cytoplasmic 2, hydroxypyruvate isomerase, ferritin light chain and peroxiredoxin-6 with  MALDI\/MS. Our results encourage more thorough future studies, in order to unravel the  complex reproductive processes of the South American camelid oviduct.","palabras_clave":"alpaca|oviduct|protein"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18492,"idioma_id":4,"titulo":"Young children are natural pedagogues","resumen":"Young children are sensitive to ostensive cues (OC), a specific set of communication signals which denote a learning context. This endows human communication with a protocol ? termed natural pedagogy ? adapted to transmit knowledge. It remains unknown whether children spontaneously communicate in this protocol. Here, we show that children display a broad repertoire of ostensive signals during pedagogically relevant moments of their discourse. We introduce an experimental setup where an adult actor plays erroneously a simple inference game which the child has previously learned how to play. This naturally shifts the child from a student to a teacher?s role in the educational dialog. In Study 1 (n = 31), we examine children?s use of ostensive cues and gestures as they develop their explanations (3?5 and 6?8-years old). We demonstrate that all children use non-verbal behaviors specifically during moments of pedagogical relevance and the dynamics? use of ostensive signals change through childhood. In Study 2 (n = 16), the adult pupil minimizes all reception to non-linguistic OC and gestures. This resulted in a decrease of children?s frequency of OC during pedagogical episodes but did not affect other gesturing behavior. In Study 3 (n = 15) we show that decreasing ostension during children?s history of instruction does not decrease their own ostension while teaching. This rejects the hypothesis that children teach by simple imitation of their learning experience and showed instead, that they can diagnose the sources of the adult pupil?s failure and adjust their own teaching accordingly. Together, these results demonstrate that children are spontaneously tuned in the emitter side of natural pedagogy.","palabras_clave":"pedagogy|teaching|development|ostensive cues|gestures"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18493,"idioma_id":4,"titulo":"Sweet and sour: music and taste associations","resumen":"Purpose This study seeks to extend current understanding concerning the cross-modal correspondences between sounds and tastes by introducing new research tools and experimental data to study associations and their reflections between music and taste. Design\/methodology\/approach The experiment design addresses the multidisciplinary approach by using cultural, chemical and statistical analysis methods. Findings The study provides further evidence that exposure to the ?sweet? or ?sour? musical pieces influences people?s food-related thinking processes and behaviors. It also demonstrates that sweet or sour elements in the music may reflect to actual sweetness (as measured by sugar content) and sourness (as measured by organic acid content) of foods developed in association with music carrying similar taste characteristics. Research limitations\/implications The findings should be replicated and expanded using larger consumer samples and wider repertoires of ?taste music? and dependent variables. Also the level of experimental control should be improved; e.g. the ?sweet? and ?sour? music were produced using different instruments, which may have an influence to the results. Practical implications Ambient ?taste music? that is congruent with the basic flavors of the dishes can be played in restaurants to highlight guests? sensory experience. Originality\/value Crossmodal associations are made between the tastes and music. This can influence on perception of food and provide new ways to build multimodal gastronomic experiences.","palabras_clave":"music|taste"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18494,"idioma_id":5,"titulo":"Cuantificación del escurrimiento  superficial  de la  Cuenca del Río Carcarañá","resumen":"La&nbsp; cuenca&nbsp; del&nbsp; Río&nbsp; Carcarañá,&nbsp; incluyendo&nbsp; a&nbsp; sus&nbsp; principales&nbsp; tributarios,&nbsp; tales&nbsp; como&nbsp; el&nbsp; Río&nbsp; Tercero&nbsp; (Ctalamochita),&nbsp; Río Saladillo,&nbsp; Arroyo Tortugas, entre otros, es una importante cuenca superficial&nbsp; ubicada en la zona central de las Provincias de Córdoba y Santa&nbsp; Fe,&nbsp; lo&nbsp; que&nbsp; la&nbsp; convierte&nbsp; en&nbsp; una&nbsp; fuente&nbsp; potencial&nbsp; de&nbsp; agua&nbsp; para&nbsp; diferentes&nbsp; usos.&nbsp; A&nbsp; pesar&nbsp; de&nbsp; la&nbsp; importancia&nbsp; de&nbsp; esta&nbsp; cuenca,&nbsp; la información hidrológica disponible es escasa&nbsp; y por lo tanto no permite llevar a cabo un manejo sustentable del&nbsp; recurso,&nbsp; por lo que es necesario&nbsp; realizar&nbsp; un&nbsp; programa&nbsp; de&nbsp; mediciones&nbsp; in&nbsp; situ&nbsp; para&nbsp; cuantificar&nbsp; el&nbsp; escurrimiento&nbsp; superficial&nbsp; del&nbsp; sistema&nbsp; para&nbsp; conocer&nbsp; sus variaciones tanto espaciales como temporales. Por ello se lleva adelante un esfuerzo conjunto entre tres instituciones de las Provincias de Córdoba y Santa Fe (CETA Universidad Nacional de Córdoba, CIFASIS CCT Rosario y la Secretaría de Recursos Hídricos del Gobiernode&nbsp; la&nbsp; Provincia&nbsp; de&nbsp; Córdoba)&nbsp; con&nbsp; el&nbsp; fin&nbsp; de&nbsp; cumplimentar&nbsp; este&nbsp; objetivo.&nbsp; En&nbsp; este&nbsp; trabajo&nbsp; se&nbsp; reportan&nbsp; los&nbsp; resultados&nbsp; obtenidos&nbsp; de&nbsp; la cuantificación&nbsp; del&nbsp; escurrimiento&nbsp; superficial&nbsp; en&nbsp; la&nbsp; cuenca&nbsp; del&nbsp; Río&nbsp; Carcarañá&nbsp; (hasta&nbsp; su&nbsp; desembocadura&nbsp; en&nbsp; el&nbsp; río&nbsp; Coronda)&nbsp; durant e&nbsp; las campañas de monitoreo&nbsp; junto a las curvas altura&nbsp; caudal calibradas en diferentes&nbsp; secciones&nbsp; del sistema&nbsp; fluvial. Dadas las características del sistema estudiado se realizaron los aforos utilizando un Perfilador de Corriente Acústico Doppler (ADCP).","palabras_clave":"ADCP|CUANTIFICACION DE l RECURSO HIDRICO|RIO CARCARAÑA|RIO TERCERO (CTALAMOCHITA)|RIO SALADILLO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18495,"idioma_id":5,"titulo":"Relación entre audición y cognición durante el envejecimiento: estudio de una población geriátrica de Rosario","resumen":"Durante el envejecimiento, la pérdida de audición es considerada como uno de los problemas de salud pública más importante por su impacto sobre el bienestar físico, emocional y social de la persona, disminuyendo de manera notable la calidad de vida de quien la padece. Esto se debe a que un déficit auditivo no sólo afecta la percepción y la comprensión del habla, también condiciona el nivel de participación social. Esto último se manifiesta en una tendencia a la depresión, a la disminución de la autoestima, al aislamiento social y al aumentosignificativo del estrés familiar, hechos que también son observables en personas con cierto grado de demencia. Diferentes autores (Pouchain, Dupuy, San Julian et al, 2007; Lin et al. 2011; entre otros) sostienen que las dificultades en la comunicación observadas en las personas adultas mayores no sólo se deben aalteraciones en la función auditiva periférica, sino también a un deterioro de las habilidades cognitivas y de las funciones auditivas centrales.En el presente trabajo se pretende considerar la relación entre las alteraciones auditivas y el grado de deterioro cognitivo.Se han explorado 35 personas, de ambos sexos, residentes en el Hospital Geriátrico Provincial de Rosario, con edades comprendidas entre los 58 y los90 años de edad.El estudio consistió en la evaluación de la función auditiva periférica y central y en la determinación del nivel cognitivo. En general se han observado una serie de correlaciones estadísticas que corroboran la estrecha relaciónentre la pérdida auditiva y el deterioro cognitivo leve durante el envejecimiento.","palabras_clave":"ENVEJECIMIENTO|PERDIDA|AUDITIVA|COGNICIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18496,"idioma_id":4,"titulo":"Verification of WRF-ARW convect ive-resolving forecasts over Southeastern South America","resumen":"p { margin-bottom: 0.25cm; line-height: 120%; }    During  November-December 2012, high-resolution (4 km-38 vertical levels),  convection-allowing 48 hours WRF-ARW forecasts were produced at the  National Weather Service of Argentina. The aim of this paper is to  evaluate hourly quantitative precipitation forecasts to assess the  model performance on representing its location, intensity, spatial  variability and diurnal cycle. The focus is on the central-east  region of Argentina and south of Brazil. The study is based on a  combination of visual comparison of forecasted and estimates  accumulated precipitation fields and objective scores calculated  employing 8-km resolution CMORPH (CPC MORPHing technique) satellite  rainfall estimations. Additional insight is gained by examining an  organized convective event occurred during 6th and 7th December,  2012. As a complement, radar data is considered to evaluate  convective features using simulated model reflectivity. Results show  that WRF model forecast captures quite well the position and timing  of the major convective events, even though the magnitude of events  was underestimated. Total amounts averaged over the verification  domain are underestimated as well as the areal coverage for small  thresholds. In general, results suggest that convection-allowing  WRF-ARW model has the potential to improve short range forecasts over  the region although it should be evaluated over a longer period of  time.     \t  \t  \t  \tp { margin-bottom: 0.25cm; line-height: 120%; }During  November-December 2012, high-resolution (4 km-38 vertical levels),  convection-allowing 48 hours WRF-ARW forecasts were produced at the  National Weather Service of Argentina. The aim of this paper is to  evaluate hourly quantitative precipitation forecasts to assess the  model performance on representing its location, intensity, spatial  variability and diurnal cycle. The focus is on the central-east  region of Argentina and south of Brazil. The study is based on a  combination of visual comparison of forecasted and estimates  accumulated precipitation fields and objective scores calculated  employing 8-km resolution CMORPH (CPC MORPHing technique) satellite  rainfall estimations. Additional insight is gained by examining an  organized convective event occurred during 6th and 7th December,  2012. As a complement, radar data is considered to evaluate  convective features using simulated model reflectivity. Results show  that WRF model forecast captures quite well the position and timing  of the major convective events, even though the magnitude of events  was underestimated. Total amounts averaged over the verification  domain are underestimated as well as the areal coverage for small  thresholds. In general, results suggest that convection-allowing  WRF-ARW model has the potential to improve short range forecasts over  the region although it should be evaluated over a longer period of  time.   ","palabras_clave":"Verification|Performance|High-resolution|Rainfall"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18497,"idioma_id":4,"titulo":"Estimating the geographic range of a threatened shark in a data-poor region: Cetorhinus maximus in the South Atlantic Ocean","resumen":"The distribution of the planktivorous basking shark, Cetorhinus maximus, is influenced by zooplankton abundance at small scales and temperature at medium scales in the North Atlantic. Here, we estimate the distribution of basking sharks on South Atlantic continental shelves, and the relative importance of chlorophyll concentration, as a proxy for zooplankton abundance, and temperature in determining habitat suitability for basking sharks at large scales. We used maximum entropy (MaxEnt) and maximum likelihood (MaxLike) species distribution modelling to test three hypotheses: the distribution of basking sharks is determined by (1) temperature, (2) chlorophyll concentration, or (3) both chlorophyll and temperature, while considering other factors, such as oxygen and salinity. Off South America, basking shark habitat included subtropical, temperate and cool-temperate waters between approximately 20oS and 55oS. Off Africa, basking shark habitat was limited to cool-temperate waters off Namibia and southern South Africa. MaxLike models had a better fit than MaxEnt models. The best model included minimum chlorophyll concentration, dissolved oxygen concentration, and sea surface temperature range, supporting hypothesis 3. However, of all variables included in the best model, minimum chlorophyll concentration had the highest influence on basking shark distribution. Unlike the North Atlantic distribution, the South Atlantic distribution of basking sharks includes subtropical and cool-temperate waters. This difference is explained by high minimum chlorophyll concentration off southern Brazil as compared to North Atlantic subtropical areas. Observations in other regions of the world support this conclusion. The highest habitat suitability for basking sharks is located close to nearshore areas that experience high anthropogenic impact.","palabras_clave":"Basking Shark|Chondrichthyes|Geographic Range|MaxEnt|MaxLike|Southern Hemisphere"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18498,"idioma_id":4,"titulo":"Evaluation of the spreading thermal resistance for rough spheres","resumen":"The solid-solid contact of rough spherical particles in packed beds takes place by the deformation of individual asperities that transmit the stresses to the main body of the particles. This causes an elastically deformed area (a disk of radius a, most usually much smaller than the particle radius) enclosing the micro-contacts. Micro thermal resistances around the contact spots can be described in terms of a profile of thermal conductance h(r) that decreases toward the disk edge. An additional thermal resistance, the spreading resistance, is caused by the convergence of flux lines in the bulk of the spheres towards the reduced section of the disk. The described mechanism has been modeled by Bahrami et al. (Bahrami M.,  M. M. Yovanovich, J. R. Culham, Effective thermal conductivity of rough spherical packed beds, International Journal of Heat and Mass Transfer, 49, 2006, 3691?3701) and a formulation was provided to predict the contribution of contact areas to the effective thermal conductivity. The spreading resistance &#61527;a is re-evaluated in this work on account of the h(r) profile, by means of numerical calculations. It is found that the shape of h(r) has a large impact on &#61527;a and a weaker, but still significant, effect on the overall contact resistance. The results of &#61527;a have been suitably correlated for a conductance profile of the form h(r) = h0 [1-(r\/a)2]p .","palabras_clave":"spreading thermal resistance|effective thermal conductivity|overall contact resistance"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18499,"idioma_id":4,"titulo":"Numerical modeling of reinforced concrete beams repaired and strengthened with SFRC","resumen":"Improved tensile properties of steel fiber reinforced concrete (SFRC) make it suitable for repairing and strengthening of reinforced concrete elements. The use of this material as repairing or strengthening material has increased during the last years motivating the development of numerical tools for the design of this type of intervention technique.  The numerical simulation of the mechanical behavior of a series of reinforced concrete beams which includes strengthened and repaired beams with high performance self compacting SFRC tested under shear is presented in this paper. SFRC is considered as a composite material composed of concrete matrix and fibers and a simple homogenization approach based on modified mixture theory is used to model its mechanical behavior. An evolutionary algorithm is proposed in order to simulate the whole process of testing, repairing and retesting the beams.  The numerical simulations can accurately reproduce flexure characterization tests and predict the bearing capacity of the repaired and strengthened beams tested under shear. Furthermore, other repairing\/strengthening options are numerically studied. The numerical results could be useful to improve the design of this kind of intervention techniques.","palabras_clave":"FIBER|REPAIRING|STRENGTHENING|SHEAR|REINFORCED CONCRETE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18500,"idioma_id":4,"titulo":"A past-millennium maximum in postglacial activity from Volcán Chaiten, southern Chile","resumen":"            Volcán Chaitén (southern Chile, ~43°S) initiated an historically unprecedented eruption in A.D. 2008, surprising the local inhabitants, Chilean and Argentine authorities, and the geologic community. Available data at the time indicated an absence of explosive eruptions from this rhyolitic volcano since a large-magnitude eruptive event dated at ca. 10,500 yr B.P. We present lake-sediment data from Lago Teo, a small closed-basin lake located in the immediate vicinity of both Chaitén township and the volcano, that spans the past ~10,000 yr and contains 26 pyroclastic fallout deposits. Glass-shard electron microprobe analyses revealed ten rhyolitic tephras indistinguishable in composition from the 2008 Volcán Chaitén eruption, and ten others potentially derived from the Michinmahuida volcanic complex. Among the rhyolites, we detected three closely spaced tephras deposited between ca. 9460 and 9680 yr B.P., followed by two thick tephras dated at ca. 7700 and ca. 5080 yr B.P. Three other closely spaced tephras occur between ca. 600 and 850 yr B.P., the most recent prehistoric event at ca. 420 yr B.P., and a 3-cm-thick tephra deposited during the 2008 event. We calculate a median recurrence of ~310 yr between eruptive events from all sources over the past ~10,000 yr, and ~200 yr between Volcán Chaitén events over the past millennium. Our results not only challenge the notion of an ~10,500-yr-long quiescence for Volcán Chaitén activity, but also suggest that the 2008 eruption was an overdue phenomenon in the context of its postglacial eruptive history, illustrating the advantage and absolute necessity of utilizing lake-sediment archives for developing continuous well-dated time series inventories of explosive volcanic events.","palabras_clave":"Tephrochronlogy|Volán Chaitén|Michinmahuida volcanic complex|eruptive history"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18501,"idioma_id":4,"titulo":"Shortest Path Algorithm for Obtaining Muscular Anthropometric Data from MRI","resumen":"In the process of generating image based subject specific musculoskeletal models and the simulation of rescaled generic musculoskeletal models, the accurate segmentation of the anatomical structures of interest from medical images determines the efficiency of the musculoskeletal system models. Efficiency is highly influenced by the image segmentation technique used. This paper presents a semi-automatic segmentation algorithm based on the Dijkstra´s shortest path algorithm for obtaining the origin and insertion points, and muscle paths from a magnetic resonance image. This algorithm significantly reduces the processing time while retaining high levels of sensitivity and specificity for the structures to be segmented. Anthropometric parameters calculated from the results obtained with the proposed algorithm are comparable to the results published by other groups of researchers. These results could be used to create an anthropometric parameters database from healthy population and with gait abnormalities that can be used in the development and simulation of rescaled generic models. In addition, the shortest path algorithm proposed in this paper could be used by the medical experts as a training algorithm of model based segmentation algorithm that may reduce processing time even more.","palabras_clave":"Musculoskeletal Models|MRI|Dijkstra?s Shortest Path Algorithm"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18502,"idioma_id":4,"titulo":"Phase development during thermal treatment of a fast-setting cordierite-mullite refractory","resumen":"Cordierite based materials are widely used in high temperature applications due to their good thermo-mechanical properties andthermal shock resistance. They are generally employed in the kiln furniture (shelves, brackets, bearing plates) for firing ceramicpieces. Because of its low expansion coefficient and dielectric properties, cordierite is also used in advanced ceramics, catalystsupports automotive, industrial waste gas purification and parts subjected to sudden temperature changes. The low intrinsicstrength of the cordierite may be compensated by the presence of mullite, forming a composite material of cordierite-mullite,extending its use to somewhat higher temperatures, at the expense of a slight increase in the thermal expansion coefficient. In thiswork a cordierite-mullite precursor was prepared from a mixture of magnesium oxide, calcined alumina, silica fume andmonoaluminum phosphate solution that produces fast setting at room temperature (~20 minutes) and then, by calcination,cordierite-mullite is generated. The evolution of the mineralogical phases was studied from room temperature to 1350 °C by Xraydiffraction, differential thermal analysis and thermogravimetry. A possible sequence of chemicals reactions throughout theheat treatment is also proposed. Adding refractory aggregates to this precursor leads to obtaining a fast-setting concrete, suitablefor the formation of individual pieces or repair service at moderately high temperatures. A summary of its main properties is alsoincluded.","palabras_clave":"CORDIERITE|REFRACTORY|MAGNESIA-PHOSPHATE BOND|FAST SETTING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18503,"idioma_id":5,"titulo":"Propiedades psicométricas de la adaptación argentina del Inventario de Alianza de Trabajo breve - versión paciente (WAI-SR-A): un análisis factorial confirmatorio","resumen":"La alianza terapéutica representa un concepto central para la investigación y el ejercicio de prácticas clínicas en psicoterapia. En este estudio se presenta la adaptación argentina del Inventario de Alianza de Trabajo en su versión breve y del paciente (WAI-SR-A), junto con el análisis de sus propiedades psicométricas. Se convocó una muestra no probabilística de 153 pacientes que se encontraban realizando tratamientos con una extensión mínima de 5 sesiones. Se condujo un análisis factorial confirmatorio que aportó evidencias en favor de la validez de constructo del instrumento. Los resultados del análisis factorial fueron replicados mediante un procedimiento de Bootstrap utilizando 500 sub-muestras aleatorias. A su vez, se analizaron los índices &#945; de Cronbach convencional y &#945; de Cronbach ordinal y las correlaciones ítem-total corregidas en las dimensiones del instrumento, mostrando que el inventario y sus tres sub-escalas presentan adecuados niveles de consistencia interna y homogeneidad. Los resultados del estudio posicionan al WAI-SR-A como un instrumento válido y confiable para el análisis de la alianza terapéutica en el contexto argentino. Contar con un inventario de estas características puede favorecer el estudio empírico y seguimiento clínico de los procesos psicoterapéuticos, beneficiando tanto a psicoterapeutas como a investigadores.","palabras_clave":"Alianza Terapéutica;| Inventario de Alianza de Trabajo; | WAI;  |Análisis Factorial Confirmatorio;"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18504,"idioma_id":5,"titulo":"Relación de las características de pacientes con trastornos por abuso de sustancias con sus niveles de satisfacción por el tratamiento","resumen":"En los últimos años, el estudio de la satisfacción por los tratamientos en pacientes con adicciones, se ha convertido en un recurso valioso para evaluar la calidad de los abordajes y predecir sus resultados. Sin embargo, no se han encontrado investigaciones que estudien condiciones de los pacientes predictoras de satisfacción. En este estudio se analiza la relación entre características de los pacientes y sus niveles de satisfacción por el tratamiento, conformando una muestra probabilística de 216 pacientes de instituciones del Área Metropolitana de Buenos Aires especializadas en adicciones. Los participantes debieron completar un cuestionario que indagaba su satisfacción respecto de diferentes elementos de los abordajes. Los análisis estadísticos mostraron que algunas variables de los pacientes se asocian con diferentes niveles de satisfacción. La pertenencia al género masculino, el estar en pareja y tener menores niveles de instrucción, se vincularon significativamente con mayor satisfacción. Menor cantidad de sustancias consumidas y motivo de consulta, se asociaron, a su vez, con un grado superior de satisfacción. Los resultados presentan la necesidad de valorar estos rasgos preexistentes al momento de diseñar los tratamientos, para adecuarlos a las especificidades de los pacientes, en busca de mejores niveles de satisfacción y, en última instancias, mejores resultados.","palabras_clave":"Satisfacción de tratamientos|Características del paciente|Variable del paciente|Adicciones|Trastorno por abuso de sustancias"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18505,"idioma_id":5,"titulo":"Agrario y no agrario: ingresos de hogares rurales argentinos","resumen":"En este artículo analizamos la evolución y los cambios que se  produjeron en las ocupaciones y en los ingresos agrícolas y no agrícolas de un  grupo de pequeños productores de las provincias de Chaco y Misiones, en la  Argentina. A partir de una encuesta realizada en los años 2000 y 2007,  construimos una tipología de hogares definida por la supremacía de la fuente de  percepción de ingresos, que nos permitió examinar comparativamente la  composición de los ingresos. Entre los hallazgos encontrados, se destaca un  incremento de los hogares pluriactivos; esta tendencia ha sido acompañada por  un mejoramiento de los ingresos procedentes de la actividad predial y por la  especialización de las tareas tanto dentro como fuera del predio.","palabras_clave":"productores agropecuarios familiares|pluriactividad|hogares|población rural"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18506,"idioma_id":5,"titulo":"El Carmen 1, un poblado intermedio tardío en el valle de Santa María (prov. de Tucumán)","resumen":"Se presentan aquí los  resultados de los trabajos de relevamiento planialtimétrico, arquitectónico y de  excavación realizados en el sitio El Carmen 1 ubicado en el valle de Santa  María, sobre la ladera oriental de la sierra del Cajón (Depto. Tafí, Provincia  de Tucumán). En base a las características de su emplazamiento, los materiales  y técnicas constructivas, el material cerámico recuperado en superficie y en excavación,  y los fechados radiocarbónicos obtenidos, permiten afirmar que el sitio El  Carmen 1 fue un poblado habitado durante la segunda mitad del período Intermedio  Tardío. Los sectores relevados corresponden a una extensa área predominantemente  montañosa a lo largo de la cual la arquitectura revela marcadas diferencias  funcionales: recintos habitacionales, arquitectura defensiva, vías de circulación.  Los datos recolectados contribuyen así al conocimiento del registro  arqueológico de los grandes asentamientos calchaquíes del siglo XIV de la Era","palabras_clave":"PERIODO INTERMEDIO TARDÍO|VALLE DE SANTA MARIA|CENTRO POBLADO|ARQUITECTURA|CERÁMICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18507,"idioma_id":4,"titulo":"What does it take to flood the Pampas? Lessons from a decade of strong hydrological fluctuations","resumen":"While most landscapes respond to extreme rainfalls with increased surface water outflows, very flat and poorly drained ones have little capacity to do this and their most common responses include (i) increased water storage leading to rising water tables and floods, (ii) increased evaporative water losses and, after reaching high levels of storage, (iii) increased liquid water outflows. The relative importance of these pathways was explored in the extensive plains of the Argentine Pampas, where two significant flood episodes (denoted FE1 and FE2) occurred in 2000-2003 and 2012-2013. In two of the most flood-prone areas (Western and Lower Pampa, 60 000 km2 each), surface water cover reached 31 and 19% during FE1 in each subregion, while FE2 covered up to 22 and 10%, respectively. From the spatiotemporal heterogeneity of the flood events, we distinguished slow floods lasting several years when the water table is brought to the surface following sustained precipitation excesses in groundwater-connected systems (Western Pampa), and 'fast' floods triggered by surface water accumulation over the course of weeks to months, typical of poor surface-groundwater connectivity (Lower Pampa) or when exceptionally-strong rainfalls overwhelm infiltration capacity. Because of these different hydrological responses, precipitation and evapotranspiration were strongly linked in the Lower Pampa only, while the connection between water fluxes and storage was limited to the Western Pampa. In both regions, evapotranspirative losses were strongly linked to flooded conditions as a regulatory feedback, while liquid water outflows remained negligible. This article is protected by copyright. All rights reserved.","palabras_clave":"inundaciones|Almacenamiento de agua|ciclo del agua regional |hiperllanuras|agua subsuperficial"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18508,"idioma_id":4,"titulo":"Latest Approaches On Green Chemistry Preconcentration Methods For Trace Metal Determination In Seawater ? A Review","resumen":"Evaluation of trace metal levels in seawater samples is undertaken regularly by research groups all over the world, leading to a growing demand for techniques involving fewer toxic reagents, less time-consuming protocols and lower limits of detection. This review focuses on providing a brief but concise description of the latest methodologies developed to this end, outlining the advantages and disadvantages of the various protocols, chelating and dispersive agents and instruments used. Conclusions are drawn on the basis of the articles reviewed, highlighting improvements introduced in order to enhance the performance of the protocols.","palabras_clave":"Green chemistry|new methodologies|Trace metals|Seawater"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18509,"idioma_id":4,"titulo":"Role of nutrients in the phytoplankton development during a winter diatom bloom in an eutrophic South American Estuary (Bahía Blanca, Argentina)","resumen":"The Bah´&#305;a Blanca Estuary is considered highly eutrophic. Long-term studies have shown that the winter?early spring bloom can be considered the development of a diatom assemblage with Thalassiosira curviseriata as the dominant species. Since 2003, several changes have been observed in the annual pattern of nutrients and phytoplankton. To assess the availability of nutrients and their relationship with phytoplankton development, nutrient variability was studied during a winter bloom in 2003 (April 22?September 4). Nitrite, nitrate, ammonium, phosphate, silicates, chlorophyll-a, phytoplankton abundance, particulate organic matter, and physicochemical parameters were measured in surface water at Cuatreros Port. In the Sauce Chico River mouth, we determined the concentration of nutrients to estimate the input of this river. The results of this study were compared with those of a previous usual diatom bloom from 2002. In 2003, the bloom was dominated by the Cyclotella sp. with high chlorophyll-a concentrations (26.5?40.4 lg L1). Thalassiosira curviseriata was present only at three sampling dates, reaching up to 19% of the total abundance. Mean values of dissolved oxygen, nitrate, oxygen saturation percentage, and salinity were significantly higher in 2003 than in 2002, while N:P ratios were significantly lower. Si was never limiting. A shift in the limiting nutrient between the years (N in 2003 and P in 2002) could have lead to a change in species dominance during the blooms. Results suggest that the nutrients levels in the coastal ecosystems at Cuatreros Port play an important role in the control of phytoplankton dynamics during the productive period and partially explain its interannual variability.","palabras_clave":"Estuaries|Phytoplankton bloom|Environmental conditions|Inorganic nutrients"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18510,"idioma_id":5,"titulo":"LOS MILLENIALS Y LAS REDES SOCIALES. ESTUDIO DEL COMPORTAMIENTO, IDEOLOGÍA, PERSONALIDAD Y ESTILOS DE VIDA DE LOS ESTUDIANTES DE CIENCIAS ECONÓMICAS DE LA UNIVERSIDAD NACIONAL DE LA PLATA A TRAVÉS DEL ANÁLISIS CLUSTER.","resumen":"El presente trabajo  analiza la investigación realizada  a la generación 'Y' que asiste a las distintas carreras de la facultad de ciencias económicas de la UNLP. Se analiza el comportamiento e interacción de esta generación de estudiantes en las Redes Sociales. Se describen las características socioeconómicas, la ideología social, política, económica y cultural de los estudiantes. Se presenta el modelo de  la personalidad de consumo de la generación Y a través de un análisis factorial confirmatorio  de diversas variables sujetas al estudio. Luego se determina mediante el análisis Cluster los segmentos que mejor describen la concepción moderna de consumo que posee esta generación para finalmente describirlos a través de sus estilos y valores de vida.","palabras_clave":"Generación Y|Conglomerados|Personalidad|Redes Sociales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18511,"idioma_id":4,"titulo":"Immune challenge but not dietary restriction affects spatial learning in the wild subterranean rodent Ctenomys talarum","resumen":"Several lines of evidence suggest that learning and triggering an immune response are both metabolically expensive and thus likely to be subject to nutritional trade-offs between them and other competing demands. Therefore,we evaluated if an immune challenge with a novel antigen affects spatial learning in the subterranean rodent Ctenomys talarum under two different dietary conditions. The results showed that immune-challenged animals were affected in their spatial learning capabilities, increasing the number of errors and marginally the timerequired to reach the goal of a complex labyrinth. No effect of the dietary restriction nor interaction between factors were observed. This work provides support for the existence of a trade-off between the costs of theimmune defense and learning abilities, indicating that when investment is required to fight infection, fewer resources are available for learning. The absence of effect of nutritional condition on this trade-off suggests that other physiological processes, besides cognition, may be limited by the energetic resources necessary to the more immediately critical immune response.","palabras_clave":"SPATIAL LEARNING|IMMUNE RESPONSE|SUBTERRANEAN RODENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18512,"idioma_id":5,"titulo":"Dormicion y tipo de suelo como determinantes de la germinación y establecimiento de Chloris berroi en la Pampa Deprimida","resumen":"RESUMEN. En los pastizales halófitos de la Pampa Deprimida la historia pastoril habría inducido deterioros en la diversidad florísticos y propiedades edáficas. La recuperación de las especies nativas de alto valor forrajero constituye una valiosa estrategia para la regeneración forrajera del sistema. Ello requiere un profundo conocimiento de los aspectos ecológicos de estas especies que, en el caso de Chloris berroi, nativa y potencial regeneradora de ambientes degradados, es desconocida. En este trabajo evaluamos dos hipótesis: (1) la dormición  de C. berroi se debe a las estructuras que recubren la cariópside e inhiben su germinación durante un cierto período después de la cosecha y (2) el establecimiento de plántulas de C. berroi es afectado por el tipo de suelo.  Realizamos dos ensayos: uno evaluó el efecto de la remoción de glumas y glumelas sobre la germinación en semillas de C. berroi con dos tiempos de almacenamiento (2 y 8 meses) y sembradas sobre tres suelos distintos (dos Natracualf típicos de estepa de halófitas contiguas pero con diferentes historias en el manejo del pastoreo (continuo\/rotativo) y un Argiudol Vértico de una pradera húmeda de mesófitas con pastoreo rotativo). El segundo evaluó la capacidad de establecimiento de la especie sobre cada suelo. La remoción de la cubierta  seminal promovió significativamente la germinación solo en las semillas de menor tiempo de almacenamiento. El tipo de suelo no afectó la germinación, en tanto, el establecimiento de plántulas se redujo significativamente sobre el Natracualf bajo pastoreo continuo. Los resultados sugieren que efectivamente las cubiertas seminales inducirían dormición por algunos meses (< 8). El pastoreo rotativo favorecería la preservación de C berroi en las comunidades halófitas y su ausencia en las comunidades vegetales correspondiente a suelos Argiudol vértico  no respondería a cuestiones edáficas.","palabras_clave":"pastizal|ambiente halomórfico|especie nativa"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18513,"idioma_id":4,"titulo":"Emplacement history and inflation evidence of a long basaltic lava flow located in Southern Payenia Volcanic Province, Argentina","resumen":"The El Corcovo lava &#64258;ow, from the Huanul shield volcano in the southern Mendoza province (central-western Argentina) traveled a distance of 70 km and covered a minimum area of ~415 km2. The&#64258;ow emplacement was controlled both by extrinsic (e.g., topography) and intrinsic (e.g., lava supply rate, lava physicochemical characteristics) factors. The distal portion of the lava &#64258;ow reached the Colorado River Valley, in La Pampa Province, where it spread and then was con&#64257;ned by earlier river channels. Cross-sections through the &#64258;ow surveyed at several localities show two vesicular layers surrounding a dense central section, where vesicles are absent or clustered in sheet-shaped and cylindrical-shaped structures. Lavas of the El Corcovo &#64258;ow are alkaline basalts with low values of viscosity.The morphological and structural characteristics of the &#64258;ow and the presence of landforms associated with lava accumulation are the evidence of in&#64258;ation. This process involved the formation of a tabular sheet &#64258;ow up to 4 m of thick with a large areal extent in the proximal sectors, while at terminal sectors frontal lobes reached in&#64258;ation values up to 10 m.Thenumerous swelling structures presentat the seportions of the &#64258;ow suggest the movement of lava in lava tubes. We propose that this aspect and the low viscosity of the lava allowed the &#64258;ow travel to a great distance on a gentle slope relief.","palabras_clave":"Back-arc volcanism|Payenia|Basalt flow|Inflation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18514,"idioma_id":4,"titulo":"Simple thiol-ene click chemistry modification of SBA-15 silica pores with carboxylic acids","resumen":"A straightforward approach for anchoring tailored carboxylic groups in mesoporous SiO2 colloidal materials is presented. The thiol-ene photochemical reaction between vinyltrimethoxysilane precursors and various thiocarboxylic acids which has, click chemistry features (i.e. high conversion yields, insensitivity to oxygen, mild reaction conditions), results in carboxylated silane precursors that can be readily used as surface modifiers. The carboxylic groups of acetic, undecanoic and succinic acid were immobilized on the  silica mesopore walls of SBA-15 powders employing the synthesized silane precursors. Post-grafting has been confirmed through infrared spectrometry (FTIR), energy dispersive X-ray spectroscopy (EDS), elemental analysis (EA) and zeta potential measurements. Detailed field-emission gun scanning electron microscopy (FESEM) images and small angle X-ray scattering (SAXS) data revealed parallel mesopores and ordered mesostructures. It is shown that the immobilized COOH groups are chemically accessible for acid?base reactions as well as copper adsorption. Immobilization of easily synthesized tailored carboxylic  modified alkoxide precursors within mesoporous systems provides a unique chemical nanoenvironment within these ordered frameworks.","palabras_clave":"Mesostructured materials|Functionalized SiO2|Carboxylic groups|Click chemistry|Thiol-ene addition|SBA-15"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18515,"idioma_id":4,"titulo":"Two-dimensional spectroscopy for the study of ion Coulomb crystals","resumen":"Ion Coulomb crystals are currently establishing themselves as a highly controllable test bed for mesoscopic systems of statistical mechanics. The detailed experimental interrogation of the dynamics of these crystals, however, remains an experimental challenge. In this work, we show how to extend the concepts of multidimensional nonlinear spectroscopy to the study of the dynamics of ion Coulomb crystals. The scheme we present can be realized with state-of-the-art technology and gives direct access to the dynamics, revealing nonlinear couplings even in the presence of thermal excitations. We illustrate the advantages of our proposal showing how two-dimensional spectroscopy can be used to detect signatures of a structural phase transition of the ion crystal, as well as resonant energy exchange between modes. Furthermore, we demonstrate in these examples how different decoherence mechanisms can be identified.","palabras_clave":"TWO DIMENSIONAL SPECTROSCOPY|TRAPPED IONS|NONLINEAR DYNAMICS|QUANTUM OPTICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18516,"idioma_id":5,"titulo":"Asociación entre polimorfismos del gen NAT2 y Fisura labiopalatina no sindrómica en Argentina","resumen":"Background: NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines, hydrazine drugs, and a great number of toxins and carcinogens present in diet, cigarette smoke, and environment. Aim: To determine the association between alleles determining slow acetylator phenotype and the risk of NSCLP. Material and Methods: We analyzed *5 (481 C>T), *6 (590G>A) and *7 (857G>A) alleles which determine the slow acetylator phenotype and polymorphism in 97 progenitor-case trios of NSCLP in Argentinian Obstetric Wards. We evaluated the transmission disequilibrium (TDT). REsults: TDT showed a positive association between allele *5 and NSCLP (odds ratio = 1,6; p = 0,03). Conclusions: The presence of *5 allele is significantly higher in cases with congenital NSCLP.","palabras_clave":"Ceft lip|Cleft palate|Arylamine N-Acetyltransferase"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18517,"idioma_id":5,"titulo":"Competencias adquiridas y aplicadas por pasantes del Instituto de Fisiopatología Cardiovascular","resumen":"En Argentina, los alumnos universitarios participan poco en investigación. El Instituto de Fisiopatología Cardiovascular (INFICA), Facultad de Medicina, Universidad de Buenos Aires, los incluyó en tareas investigativas desde 1992. El objetivo del trabajo es analizar qué competencias adquirieron quienes fueron o son pasantes del INFICA y en qué aspectos de su vida académica y profesional las aplican. Se administró una encuesta estructurada, voluntaria y anónima, con datos personales y académicos, conocimientos y habilidades adquiridas y utilidad de los mismos. La tasa de respuesta fue: 66%; 71% fueron mujeres; edad promedio 28,7 años (DE= 7,37). El 88% tiene como carrera medicina, siendo el 52%, graduado. Los alumnos aprendieron recopilación (86,6%) y análisis (80%) de datos. El 80% lo utiliza para comprender temas en clases y el 60% para elaborar trabajos escritos. El 94% de los graduados realizó formación de postgrado, aplicando las siguientes competencias: análisis (93,3%) y recopilación (80%) de datos y elaboración y exposición de trabajos científicos (80%). Las utilizan en la participación (93,3%) y comprensión (73.3%) de temas en actividades académicas. El 66% de los graduados tiene actividad profesional, aplicando las competencias en exposición (100%) y elaboración (90,9%) de trabajos científicos. En consecuencia, los pasantes adquieren competencias relacionadas con recopilar, analizar datos y elaborar y exponer trabajos científicos, siendo aplicables en varios aspectos de su formación y profesión. En definitiva, la pasantía les ha brindado las bases a los futuros profesionales acerca de la metodología de la investigación e incentivado la producción científica.","palabras_clave":"INVESTIGACIÓN|EDUCACIÓN MÉDICA|ALUMNOS|EVALUACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18518,"idioma_id":4,"titulo":"Thermal Degradation Kinetics of Monomeric Anthocyanins, Colour Changes and Storage Effect in Elderberry Juices","resumen":"BACKGROUND: Elderberry (Sambucus nigra L.) is considered an interesting fruit as food ingredient, due to its high content ofanthocyanins that give products an attractive red colour.OBJECTIVE: The aim of present study was to evaluate the kinetics of elderberry monomeric anthocyanin (MAcy) and colourdegradation due to thermal processing and storage.METHODS: Anthocyanins content was measured with pH-differential method. CIELab parameters were obtained with a MinoltaSpectrophotometer, total phenolics were determined by Folin-Ciocalteu method. MAcy degradation and evolution of colourparameter a&#8727; were fitted to a first?order model.RESULTS: The degradation rate of a&#8727; was about three times lower than MAcy degradation rate. Activation energy for degradationof a&#8727; and MAcy were 140.6 and 144.6 kJ mol&#8722;1 respectively. Degradation rates (k) obtained during storage were 0.025 d&#8722;1 forMAcy and 0.0064 d&#8722;1 for a&#8727;. During storage, 50% reduction of initial values was at 120 days for MAcy and at 432 days for colourparameter a&#8727; at 25ºC. However, a high retention of polyphenols and antioxidant was noted.CONCLUSIONS: Kinetic parameters calculated for elderberry juice can be used to design a thermal treatment to obtain a highretention of colour and bioactive compounds.","palabras_clave":"EDELBERRY|ANTHOCYANINS|COLOR|STABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18519,"idioma_id":4,"titulo":"Optimizing culture medium composition to improve oligodendrocyte progenitor cell yields in vitro from subventricular zone derived neural progenitor cell neurospheres","resumen":"Neural Stem and Progenitor Cells (NSC\/NPC) are gathering tangible recognition for  their uses in cell therapy and cell replacement therapies for human disease, as well as  a model system to continue research on overall neural developmental processes in  vitro. The Subventricular Zone (SVZ) is one of the largest NSC\/NPC niches in the  developing mammalian CNS, and persists through to adulthood. OPC enriched  cultures are usefull tools for in vitro studies as well as for cell replacement therapies for  treating demyelination diseases. We used SVZ-derived NSC\/NPC primary cultures  from newborn mice and compared the effects of different growth factor combinations  on cell proliferation and oligodendrocyte progenitor cell (OPC) yield. The Platelet  Derived Growth Factor-AA and BB homodimers had a positive and significant impact  on OPC generation. Furthermore, heparin addition to the culture media contributed to  further increase overall culture yields. The OPC generated by this protocol were able to  mature into Myelin Basic Protein (MBP)-expressing cells and to interact with neurons in  an in vitro co-culture system. As a whole, we describe an optimized in vitro method for  increasing OPC.","palabras_clave":"células madre|oligodendrocito|neuroesferas|cultivo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18520,"idioma_id":5,"titulo":"ANÁLISIS BIOMÉTRICO DE RESTAURACIONES CORONARIAS TOTALES REALIZADAS EN  CÁTEDRA DE CLÍNICA DE PRÓTESIS, FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD NACIONAL DE CORDOBA","resumen":"RESUMEN     OBJETIVO: observar, analizar y comparar si las restauraciones coronarias respetan formas y proporciones de los dientes naturales  utilizando sondas que cuantifican estas dimensiones.  MATERIALES Y MÉTODOS: en este estudio se utilizó el instrumento T de CHU para medir largo y ancho de 50 incisivos centrales y laterales superiores, en pacientes de ambos sexos, con salud periodontal, no fumadores, entre 25 y 50 años, previo al tallado y luego de terminadas las coronas definitivas. Las mediciones previas a las restauraciones se consideraron grupo control.  Los valores obtenidos se tabularon y sometieron a un análisis estadístico mediante el Test de Wilcoxon de muestras apareadas.  RESULTADOS: se observó que las restauraciones coronarias de los dientes medidos y posteriormente tratados, son más cortos y anchos que antes del procedimiento protésico ya que se obtuvieron variaciones en el promedio (mm) de la longitud y del ancho (p-valor= 0,0001).  CONCLUSIÓN: el uso del instrumento T de CHU garantiza la elaboración de restauraciones coronarias con proporciones adecuadas ya que estandariza las dimensiones en ancho y largo.  PALABRAS CLAVES: Instrumento de CHU, restauración coronaria, proporciones estéticas.","palabras_clave":"INSTRUMENTO DE CHU|RESTAURACIÓN CORONARIA|PROPORCIONES ESTÉTICAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18521,"idioma_id":5,"titulo":"Los recursos naturales en Argentina y Brasil. Inserción internacional intensiva en recursos naturales.","resumen":"A través del despliegue de una serie de estrategias discursivas, las 'nuevas industrias extractivas' pretenden despojarse y diferenciarse de las 'viejas industrias extractivas'. Para ello buscan asociarse con el discurso de la modernización tecnológica la cual posibilitaría al ser humano incrementar exponencialmente el bienestar a partir de los recursos naturales existentes precisamente sin enfrentar el agotamiento de los mismos y sin experimentar impactos ambientales negativos.  El presente trabajo pretende abordar, para los casos de Argentina y Brasil, la pregunta en torno a ¿cómo se realiza la producción\/extracción de los recursos naturales?, en especial a lo que refiere a la intensidad en recursos hídricos y en volumen de recursos naturales, a través del estudio de la Huella hídrica y la Huella ecológica, respectivamente.   Complementariamente, el estudio de la balanza comercial física permitirá caracterizar el patrón de inserción en el comercio internacional a partir de responder ¿qué bienes se producen con dichos procesos productivos?  Estos elementos permitirán visibilizar cómo parece estar configurándose un estilo de desarrollo basado en la utilización a gran escala de los recursos naturales y con dudosa sustentabilidad ambiental.","palabras_clave":"Desarrollo sustentable|Inserción externa|Economía Ecológica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18522,"idioma_id":4,"titulo":"Planktonic eukaryote molecular diversity: discrimination of minerotrophic and ombrotrophic peatland pools in Tierra del Fuego (Argentina)","resumen":"We investigated the composition of the smallest size fraction (< 3 µm) of eukaryotic plankton communities of five pools located in the Rancho Hambre peat bog in Argentinean Tierra del Fuego with an Illumina HiSeq massive sequencing approach applied to the v9 region of the eukaryotic SSU rRNA gene. Communities were generally dominated by chrysophytes, with a good representation of Perkinsea and Cercozoa clade NC-10. A community composition analysis performed using GUniFraC separated minerotrophic and ombrotrophic sites, reflecting perfectly the classification of the sites based on environmental data. However, this separation disappeared when more weight was given to abundant phylotypes, suggesting that subordinate phylotypes were responsible for site discrimination. The 5% best indicators for, respectively, minerotrophic and ombrotrophic environments were searched using an IndVal analysis. Amogst these, autotrophic taxa were more common in minerotrophic environments, whereas mixotrophic taxa represented best ombrotrophic water bodies. However, the ecological traits of many taxa have still not been determined, and still needs to be investigated for a better understanding of freshwater systems ecology.","palabras_clave":"UNKNOWN DIVERSITY|NEXT GENERATION SEQUENCING|COMMUNITY|MIXOTROPH|PROTIST|ALGAE|PARASITOID"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18523,"idioma_id":5,"titulo":"Variedad Lingüística y Fonética en el Aula de ELSE","resumen":"En este trabajo nos proponemos reflexionar acerca  del abordaje de la variedad lingüística en la enseñanza de la fonética del  español. El alumno extranjero está inmerso e interactúa en una comunidad lingüística determinada que debería ser considerada a la  hora de la enseñanza de ELE.Siguiendo  el planteo de Acuña (2009), acordamos en que existe una diversidad cultural que  el alumno extranjero debe conocer para lograr una mejor integración en la comunidad  en la que vive. Con respecto a la variedad lingüística específica de San Luis,  contamos con los estudios realizados por Vidal de Battini (1949, 1964) en los  que se describen diferentes niveles de la lengua, tales como fonético,  morfológico y sintáctico. En este trabajo, nuestro interés se centra en el  lugar que ocupa el aspecto fonético en la enseñanza de ELE; concretamente la  pronunciación regional que corresponde a la vibrante simple y doble. En este contexto, se espera que los alumnos extranjeros que aprenden español en San  Luis, identifiquen las particularidades fonéticas propias de la variedad  sanluiseña. Una propuesta didáctica sobre el tema abordado podría implementarse  a través de muestras de lengua de material auténtico (programas radiales y televisivos  locales) y la posibilidad concreta de interacción con hablantes nativos por  medio de actividades enmarcadas en el enfoque por tareas. Si bien asumimos la  importancia de los rasgos fonéticos en la comprensión de la variedad, adherimos  a los estudios que no priorizan la fonética a nivel de la producción, tal como  lo proponen los fundamentos del examen CELU.","palabras_clave":"VARIEDAD|FONÉTICA|ENSEÑANZA|ELE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18524,"idioma_id":5,"titulo":"ACEITE ESENCIAL Y MORFOANATOMIA DE ÓRGANOS VEGETATIVOS DE Tagetes minuta (ASTERACEAE)","resumen":"Se presenta la composición del aceite esencial (AE) de Tagetes minuta L. de una población de la localidad de El Mollar, Tucumán y se describe la morfoanatomía de los órganos vegetativos y de las estructuras glandulares productoras de esencia. El AE mostró un elevado contenido de (Z)-tagetona, (Z)-&#61538;-ocimeno y dihidrotagetona, junto a cantidades menores de (E)-tagetona y limoneno. Anatómicamente se destaca la presencia de cavidades secretoras ovales y tricomas glandulares.","palabras_clave":"Tagetes minuta|aceite esencial|tejidos secretores"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18525,"idioma_id":4,"titulo":"Development of a Recombination System for the Generation of Occlusion Positive Genetically Modified Anticarsia Gemmatalis Multiple Nucleopolyhedrovirus","resumen":"Anticarsia gemmatalis is an important pest in legume crops in South America and it has been successfully controlled using Anticarsia gemmatalis Multiple Nucleopolyhedrovirus (AgMNPV) in subtropical climate zones. Nevertheless, in temperate climates its speed of kill is too slow. Taking this into account, genetic modification of AgMNPV could lead to improvements of its biopesticidal properties. Here we report the generation of a two-component system that allows the production of recombinant AgMNPV. This system is based on a parental AgMNPV in which the polyhedrin gene (polh) was replaced by a bacterial &#946;-galactosidase (lacZ) gene flanked by two target sites for the homing endonuclease I-PpoI. Co-transfection of insect cells with linearized (I-PpoI-digested) parental genome and a transfer vector allowed the restitution of polh and the expression of a heterologous gene upon homologous recombination, with a low background of non-recombinant AgMNPV. The system was validated by constructing a recombinant occlusion-positive (polh+) AgMNPV expressing the green fluorescent protein gene (gfp). This recombinant virus infected larvae normally per os and led to the expression of GFP in cell culture as well as in A. gemmatalis larvae. These results demonstrate that the system is an efficient method for the generation of recombinant AgMNPV expressing heterologous genes, which can be used for manifold purposes, including biotechnological and pharmaceutical applications and the production of orally infectious recombinants with improved biopesticidal properties.","palabras_clave":"AgMNPV|recombinant baculovirus|bioinsecticide|Anticarsia gemmatalis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18526,"idioma_id":5,"titulo":"La confianza como un pilar de la autoestima y del autoconcepto de los alumnos  de Inglés con Fines Específicos.","resumen":"La confianza en sí mismo o autoconfianza influye en todos los órdenes de la vida e incluso en el  ámbito  académico.  Favorece  el  aprendizaje  y  permite  un  mejor  desarrollo  de  las capacidades.  A  su  vez  nutre  la  autoestima  y  el  autoconcepto  y  se  basa  en  el  compromiso asumido  junto  con  la  responsabilidad  tomada  durante  el  aprendizaje.  Para  alcanzar  ciertos objetivos  educativos,  el  alumno  necesita  tener  confianza  en  que  logrará  lo  que  se  propone, para, de este modo, enfrentar los desafíos. Por el contrario, la falta de confianza puede socavar el  desempeño  académico.  Por  ello,  en  el  presente  trabajo  se  plantea  como  hipótesis  que  la confianza  en  sí mismo  representa  uno  de  los  pilares  de  la  autoestima  y  del  autoconcepto;  y como tal contribuye al aprendizaje de Inglés con fines Específicos. Como objetivos, se busca, por un lado, comprender y, por otro, describir cómo la autoconfianza se constituye en pilar del autoconcepto y de la autoestima en el proceso de aprendizaje. La metodología es cualitativa descriptiva y se desarrollará por medio de encuestas semi-estructuradas.","palabras_clave":"autoconcepto|autoconfianza|autoestima|inglés con fines específicos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18527,"idioma_id":5,"titulo":"Educación Emocional en alumnos  universitarios de Inglés con Fines Específicos","resumen":"La  educación  es  un  proceso  caracterizado  por  las  relaciones  interpersonales,  las  cuales  se encuentran  desbordadas  por  fenómenos  emocionales.  La  dimensión  emocional  posee  múltiples influencias  en  el  proceso  educativo  y  está  presente,  a  su  vez,  tanto  en  el  p roceso  de  aprendizaje autónomo e individual como en uno de los grandes objetivos del ser humano, el autoconocimiento. En las últimas décadas, se evidencian índices elevados de dificultades en el aprendizaje, estrés durante los exámenes, abandonos en los estudios y otros fenómenos relacionados con el fracaso académico. Estos  hechos  producen  estados  emocionales  negativos,  como  la  apatía,  el  bajo  rendimiento,  o  la deserción  y  se  pueden  relacionar  con  déficits  en  la  madurez  y  el  bienestar  emocional.  A  partir  del concepto de Inteligencia Emocional, surge la Educación Emocional como respuesta a déficits en la formación  básica  e  implica  prevenir  a  través  del  sistema  educativo  los  efectos  de  las  emociones negativas,  especialmente  en  el  aprendizaje.  Este  trabajo  pretende  indagar  acerca  de  la  Educación Emocional  que  poseen  los  alumnos  de  Idioma  Moderno:  Inglés  de  la  Facultad  de  Humanidades, UNCa a través de una encuesta-cuestionario de Desarrollo Emocional. La educación emocional que los alumnos poseen puede incidir en su desempeño académico de la lengua extranjera.","palabras_clave":"COMPETENCIA|EMOCIONAL|EDUCACION|INTELIGENCIA|AUTOCONOCIMIENTO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18528,"idioma_id":5,"titulo":"Un viaje de ida y vuelta: circulación de saberes botánicos medicinales entre mapuche y españoles en el Reino de Chile, ss. XVII- XVIII","resumen":"La apropiación por parte de la ciencia imperial hispánica del conocimiento botánico de los nativos americanos, especialmente en lo relativo al uso y consumo de plantas medicinales, es un fenómeno ampliamente conocido y estudiado: en él, la Compañía de Jesús desempeñó un papel preponderante, puesto que los jesuitas difundieron estos conocimientos por las distintas provincias de la orden dentro del imperio, y también hacia el mundo europeo. Se sabe menos de la manera en que estos conocimientos se difundieron entre otras poblaciones indígenas y sectores subalternos de la América española, como ocurrió por ejemplo con la influencia del Florilegio Medicinal de Juan de Esteyneffer entre los sectores populares de Nueva España. Dentro de esta misma tradición podemos situar la oferta de ayuda médica realizada en 1791 por parte de las autoridades coloniales chilenas a los mapuche durante un brote epidémico de viruelas que afectó sucesivamente a las poblaciones de ambos lados de la frontera. En esa ocasión, los españoles aconsejaron a los nativos el uso de yerbas medicinales de cuyo uso se habían apropiado durante el siglo XVII, cuando los misioneros jesuitas aprendieron su utilización de los mismos indígenas. El ofrecimiento muestra entonces la vuelta a casa, después de cien años de una vasta circulación que implicó también su incorporación por parte de los sectores populares hispano-criollos, de prácticas y saberes que tenían su origen en las poblaciones y el territorio de la Araucanía. El caso, reconstruido a partir de diversas fuentes documentales y bibliográficas, ilustra la circulación de los conocimientos médicos a través de las fronteras étnicas y sociales, movida por la búsqueda común de la eficacia curativa y del aprovechamiento de los recursos botánicos locales.","palabras_clave":"APROPIACIÓN|MEDICINA|BOTÁNICA|MAPUCHE|SABERES|JESUITAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18529,"idioma_id":4,"titulo":"DIVERSITY AND INTERRELATIONSHIPS IN NUTRITIONAL TRAITS IN CULTIVATED QUINOA (CHENOPODIUM QUINOA WILLD.) FROM NORTHWEST ARGENTINA","resumen":"Quinoa (Chenopodium quinoa Willd.) is one of the oldest crops in the American continent. It has beenrecognized as an extremely nutritious grain all over the world. The importance that quinoa could play innutrition is being emphasized not only in developing countries but also in the developed world. This isthe first study reporting the nutritional characterization of Argentinean quinoa germplasm anddescribing diversity and interrelationships among nutritional traits, less studied in quinoa, which couldprovide tools for breeding strategies. Nutritional properties of quinoa accessions collected in differenteco-regions from Northwest Argentina but grown on the same environment show a wide range ofvariation with only subtle differences according to the population´s region of origin. However, Argentineanquinoa germplasm did not show clear genetic structure across regions based on nutritional traits asis the case with phenotypic and genotypic traits evaluated on a similar set of accessions.","palabras_clave":"Argentinean quinoa germplasm|Nutritional properties|Interrelationships|Breeding strategies"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18530,"idioma_id":5,"titulo":"Política y sociabilidad barrial: la memoria en torno a las 'veladas socialistas' en el Barrio de La Estación de Tandil durante el período de entreguerras","resumen":"Este artículo  se inscribe en el marco de un proceso de activación  patrimonial (Prats, 2005) impulsado por una asamblea vecinal del Barrio de  La Estación de la localidad de Tandil, ciudad de rango medio de la provincia de  Buenos Aires. Analizaremos  la construcción de la memoria colectiva (Halbwachs, 2004; Portelli, 1989), en vinculación con la identidad barrial (Gravano, 2013), centrándonos en la significación  presente de algunas prácticas sociales de antiguos vecinos y vecinas del  barrio, en particular las veladas organizadas por el Partido Socialista (PS)  -partido político con un fuerte arraigo en el mencionado barrio (Barandiarán,  2004)- en las décadas de 1920 a 1940 en espacios de sociabilidad barrial como  el Salón de la Confraternidad Ferroviaria. En dichas veladas, entre proyecciones fílmicas y espectáculos teatrales se oía  a los oradores partidarios. Para ello,  partimos de la puesta en diálogo de las fuentes de la época que se han conservado,  con los testimonios de los actores sociales que participan en la re-creación y  significación presente de aquellas prácticas. Consultamos el diario de Tandil, vinculado al  radicalismo; y el periódico Germinal,  medio de prensa cercano al PS local (si bien su director- propietario Juan Nigro señalaba que no era un órgano partidario). Y realizamos entrevistas y  registros de campo con vecinos del barrio e integrantes de la Asamblea, así  como un relevamiento de las expresiones realizadas de forma pública por esa  asociación. Para la realización de este artículo recuperamos trabajos  anteriores sobre la historia del socialismo en Tandil y en el Barrio de la  Estación en particular (Barandiarán 2003; 2004; 2009); y sobre la producción de imaginarios  identitarios urbanos y barriales en la localidad (Silva 2011; 2013).","palabras_clave":"Sociabilidad|Memoria|Patrimonio|Barrio"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18531,"idioma_id":4,"titulo":"Vitamin D3 seems more appropriate than D2 to sustain adequate levels of 25OHD: a pharmacokinetic approach","resumen":"BACKGROUND\/OBJECTIVES: The superiority of cholecalciferol (D3) over ergocalciferol (D2) in sustaining serum 25-hydroxy vitamin D (25OHD) levels is controversial. To compare D2 with D3 we performed a single-blind, placebo-controlled randomized trial spanning 11 weeks.  SUBJECTS\/METHODS: Healthy volunteers (n = 33, aged 33.4 ± 6 years) were divided into three groups (n = 11, each): D2, D3 and placebo. Treatment started with a loading dose (100 000 IU) followed by 4800 IU\/day (d) between d7 and d20 and follow-up until d77. Serum samples were obtained at baseline and at days 3, 7, 14, 21, 35, 49, 63 and 77.  RESULTS: Baseline 25OHD values in the D2 group were lower than those in the D3 and placebo groups (P o 0.01). Placebo 25OHD levels never changed. As after the loading dose both D2 and D3 groups had reached similar 25OHD levels, we tested equivalence of the area under the concentration × time curve (AUC) between d7 and d77. The AUC was 28.6% higher for D3 compared with D2, and both were Q1 higher with respect to placebo. At d77, D2 25OHD levels were higher than those at baseline, but similar to placebo; both were lower than D3 (P o 0.04). According to raw data, the elimination half-life of 25OHD was 84 and 111 days under D2 and D3 supplementation, respectively; after subtracting the placebo values, the corresponding figures were 33 and 82 days.  CONCLUSIONS: D2 and D3 were equally effective in elevating 25OHD levels after a loading dose. In the long term, D3 seems more appropriate for sustaining 25OHD, which could be relevant for classic and non-classic effects of vitamin D.","palabras_clave":"VITAMIN D|PHARMACOKINETIC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18532,"idioma_id":4,"titulo":"Trophic roles of scavenger beetles in relation to decomposition stages and seasons","resumen":"ABSTRACT. Carcasses represent a trophic and reproductive resource or shelter for arthropods, which are a representative component of the decomposition process. Four experiments, one per season, were conducted in a semi-rural area of Bahía Blanca, Argentina, to study the trophic roles of cadaveric beetles, evaluating the abundance, composition and dominance during all decomposition stages and seasons. Species of necrophagous, necrophilous and omnivorous habits were found. Abundance, composition and dominance of beetles in relation to their trophic roles changed according to seasons and decomposition stages. Guilds and patterns of succession were established in relation to those periods. Trophic roles could be an indicator of beetle associations with decomposition stages and seasons.","palabras_clave":"fauna carroñera|roles ecológicos|entomología forense|sucesión de insectos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18533,"idioma_id":4,"titulo":"Avulsion at a drift-dominated mesotidal estuary: The Chubut River outlet, Patagonia, Argentina","resumen":"The Chubut River flows from the Andes to the Atlantic Ocean, and is  interrupted by a single dam constructed at the Middle valley. The lower valley  is dominated by the aggradation of an alluvial plain induced by a complex of  spits that enclosed the inlet in the last 5000 years. The river has reduced its  flow since the blocking of the upper basin by terminal moraines during the  Upper Pleistocene. At least the last two marine transgressions have flooded  this estuary, and contributed to the aggradation during regressions. The area  is of particular interest in regard to irrigation channels practiced since the  XIX century. Today, the mean monthly flow is less than 10 m3\/s although  peaks of 95 m3\/s have been recorded in Gaiman in July 2001 The  dynamics of the estuary is dominated by waves (wave-dominated estuary) as tidal  effects attenuate in less than 5   km. Three vibracores were collected within this  floodplain: a) at Gaiman, an area without any effect of the sea (37 km from the coast); b) at  Trelew, at the former avulsion plain of the river (18 km from the coast), and c)  at Playa Magagna, a saltmarsh located 1 km from the beach.    a)       At  the Gaiman core (1.54 m  long) fresh-water epiphytic diatoms dominate (Epithemia sorex, Cocconeis placentula, Ulnaria ulna) suggesting the  aggradation of an alluvial plain.     b)       The  Trelew core (2.19 m  long) was collected from a deltaic plain. It was composed by fine sand with  organic matter at the base that evolved into silty layers to the top. Several  unconformities and laminae with heavy minerals were detected by their  geochemical composition analysed by micro X-ray fluorescence (Itrax XRF core  scanner). Fine-sand laminated layers were perfectly detected by their high  content in S and Cl. On the other hand, mud layers presented lower content in  Mg and Al with increments in Ca and V.     c)       The  core from the marsh area (1.67   m long) was analyzed in terms of the diatom evolution in  order to detect Holocene sea-level and salinity effects. The sand flats from  the bottom of the core were dominated by Nitzchia  navicularis (mesohalobous and benthic taxa) and evolved into mixed flats,  mudflats and marshes to the top. Sharp contacts have been detected between  these facies, with wavy and lenticular bedding characterising the mixed flat  deposits. The middle of the sequence is dominated by a coastal marine diatom (Paralia sulcata) while the top was  dominated by Pinnularia borealis, an  aerophilous and brackish\/freshwater taxa.","palabras_clave":"avulsion|lower floodplain|diatoms|pollutants"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18534,"idioma_id":4,"titulo":"Organochlorine pesticides and PCBs in Southern Right Whales (Eubalaena australis) breeding at Península Valdés, Argentina","resumen":"Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were assessed in blubber from 35 deadSouthern Right Whales (SRW ? Eubalaena australis) stranded at Península Valdés, Argentina. The life cycle in-cludes a feeding period in high productivity areas of the South West Atlantic and a reproductive period in coastaltemplate waters of Argentina. Organochlorine pesticides showed higher concentrations (22.6 ± 13.8 ng·g&#8722;1ww)than PCBs (7.5 ± 10 ng·g&#8722;1ww). Among pesticides, HCHs, DDTs, endosulfans, dieldrin, chlordans, heptachlorepoxide, and trans-nonachlor were detected. p,p&#8242;-DDE and p,p&#8242;-DDT were present in 69% and 26% of samples,respectively. p,p&#8242;-DDT\/p,p&#8242;-DDE ratio showed low values (b0.33) as a result of aged DDT inputs. However, the oc-currence of only p,p&#8242;-DDT in some samples suggests a recent pesticide input. &#945;-HCH\/&#947;-HCH ratio (bDL-0.37)indicated no recent contribution of technical HCH mixture and\/or current use of lindane. Dieldrin was presentin 77% of the samples and endosulfan was detected in all samples with predominance of &#945;- (75%) over &#946;-endosulfan (19%) and scarce contribution of endosulfan sulphate (7%), suggesting a recent input of this insecti-cide to the environment in the SRW foraging area. A predominance of pentachlorobiphenyls was observed. In 21samples at least one PCB indicator was found and PCB #118, highly toxic, contributed in 5% to total PCBs.Although all these organochlorine compounds are forbidden they were bioaccumulated in the blubber of SRWwith a predominance of endosulfans, the more recently used pesticide. The absence of data on chemical pollut-ants in stranded dead whales is highlighted as a priority for research. This is the &#64257;rst study on levels, composi-tional patterns, and organochlorine sources in SRW. Moreover, more research including milk, and othertissues\/organs is recommended considered that in the studied specimens, mostly calves, pollutants are likelytransferred from the mother during pregnancy and nursing.","palabras_clave":"ballena|poluentes organicos persistentes|acumulacion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18535,"idioma_id":5,"titulo":"El problema de la equidad en las universidades del Conurbano bonaerense en la Argentina: un análisis de políticas institucionales para favorecer la retención","resumen":"El artículo analiza las políticas institucionales de cuatro universidades del Conurbano bonaerense en Argentina tendientes a procurar una mayor equidad en el ingreso y la retención de los alumnos de estratos sociales bajos de la población. Como se observa en todo el sistema universitario argentino, la gratuidad y el ingreso relativamente irrestricto no aseguran la equidad y los alumnos provenientes de los estratos socio-económicos más bajos de la población representan un número exiguo. El caso de estudio es el de las universidades del Conurbano bonaerense, región caracterizada por concentrar un gran porcentaje de población con altas tasas de necesidades básicas insatisfechas. El artículo se aboca a analizar las perspectivas de docentes y coordinadores de los cursos de ingreso y del primer año de algunas carreras acerca de cómo se han implementado las políticas institucionales en las cuatro universidades y cuáles pueden ser los condicionantes del mantenimiento de la inequidad.","palabras_clave":"Universidades del Conurbano Bonaerense|Equidad en Educación Superior|Estrategias de retención|Políticas educativas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18536,"idioma_id":4,"titulo":"Antimalarial activity of novel imidazoisoquinolinone derivatives correlates with heme binding affinity","resumen":"A series of novel imidazoisoquinolinone derivatives were synthesized and evaluated for in vitro antimalarial efficacy against chloroquine sensitive GHA strain of Plasmodium falciparum. Compounds 2, 4, 6, 9, and 17 revealed moderate to good activities in the micromolar range. Binding interaction between these active compounds and heme were determined and correlated with antimalarial activity. A good correlation (r = 0.98) was observed between antimalarial activity and the heme dissociation constants (Kd). These suggest that antimalarial mode of action of this class of compounds appears to be similar to that of chloroquine and involves the inhibition of hemozoin formation.","palabras_clave":"MALARIA|IMIDAZOISOQUINOLINONES|ANTIPLASMODIAL|HEMOZOIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18537,"idioma_id":4,"titulo":"Differential contribution of soil biota groups to plant litter decomposition as mediated by soil use","resumen":"Plant decomposition is dependant on the activity of the soil biota and its interactionswith climate, soil properties, and plant residue inputs. This work assessed the rolesof different groups of the soil biota on litter decomposition, and the way they aremodulated by soil use. Litterbags of different mesh sizes for the selective exclusionof soil fauna by size (macro, meso, and microfauna) were filled with standardizeddried leaves and placed on the same soil under different use intensities: naturalizedgrasslands, recent agriculture, and intensive agriculture fields. During five months,litterbags of each mesh size were collected once a month per system with fivereplicates. The remaining mass was measured and decomposition rates calculated.Differences were found for the different biota groups, and they were dependant onsoil use. Within systems, the results show that in the naturalized grasslands, themacrofauna had the highest contribution to decomposition. In the recent agriculturalsystem it was the combined activity of the macro- and mesofauna, and in theintensive agricultural use it was the mesofauna activity. These results underscore therelative importance and activity of the different groups of the edaphic biota and theeffects of different soil uses on soil biota activity.","palabras_clave":"Litterbags,|Organic matter turnover|Soil use|Soil fauna|Agroecosystem,"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18538,"idioma_id":4,"titulo":"Laboratory population parameters and field impact of the larval endoparasitoid Pseudapanteles dignus (Hymenoptera: Braconidae) on its host Tuta absoluta (Lepidoptera: Gelechiidae) in tomato crops in Argentina","resumen":"The tomato moth Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) is a key pest of tomato Lycopersicon esculentum L. crops in Central and South America. At present it is dispersing rapidly in Africa and Eurasian continents as an invasive pest, threatening the worldwide tomato production. Pseudapanteles dignus (Muesebeck) (Hymenoptera: Braconidae), is an American endoparasitoid reported as the main natural enemy of T. absoluta in commercial tomato. To gain knowledge of the potential role of P. dignus in the biological control of this pest we determined its population parameters in laboratory and the parasitoid impact on T. absoluta in the field. In laboratory, lifetime fecundity was 193 eggs per female, and longevity was 24 and 26 days for female and male, respectively. The finite rate of increase (&#955;) was 1.15 per female per day and the intrinsic rate of natural increase (rm) was 0.14. The net reproductive rate (R0) was found to be 51.15, and generation time (T) 28.80 days. The time for doubling the population (DT) was 5 days. Furthermore, field impact of parasitism that is the total mortality P. dignus is capable of inflicting on T. absoluta population, ranged from 33 to 64% in the different years studied. Population parameters estimated in this study can be considered baseline information for a mass rearing protocol of this parasitoid. Moreover, growth rates of P. dignus, particularly rm and its impact on field populations of T. absoluta indicated that this parasitoid would be a reliable candidate for biological control of this pest.","palabras_clave":"SOUTH AMERICAN TOMATO MOTH|PARASITOID|LIFE TABLE|DEMOGRAPHIC PARAMETERS|LYCOPERSICON ESCULENTUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18539,"idioma_id":5,"titulo":"Construcción de un Banco de Ítems de Analogías Verbales como base para un Test Adaptativo Informatizado","resumen":"Se presenta la construcción de un Banco de Ítems (BI) de Analogías Verbales que servirá de base para el desarrollo de un Test Adaptativo Informatizado. La construcción del BI demandó 3 fases de incorporación de ítems que fueron administrados a 3 muestras de 547, 552 y 849 estudiantes universitarios, respectivamente. El método de anclaje de ítems permitió que todas las estimaciones estuvieran en la misma escala. En cada fase se aplicaron los análisis estadísticos clásicos y los correspondientes a la Teoría de Respuesta al Ítem. Se obtuvo un BI compuesto por 64 ítems unidimensionales calibrados con el Modelo Logístico de Tres Parámetros, que no evidenciaron funcionamiento diferencial por género, presentaron adecuada capacidad discriminativa y un nivel de acierto por azar cercano al esperable. El BI permite evaluar con precisión los niveles de habilidad comprendidos entre -1.75 y 3.00. Resultó más informativo para los niveles centrales y altos de la habilidad.","palabras_clave":"Test a Medida |Modelo Logístico de Tres Parámetros |Funcionamiento Diferencial del Ítem |Razonamiento Verbal"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18540,"idioma_id":4,"titulo":"Evolution during refrigerated storage of bioactive compounds and quality characteristics of grapefruit [Citrus paradisi (Macf.)] juice treated with UV-C light","resumen":"The effect of the UV-C light (doses: 0.0 to 3.94 J\/cm²) on the main bioactive compounds of grapefruit juice and their stability were evaluated throughout 30 and 16 days of storage at 4 and 10 °C respectively. Organic acids (citric, malic, ascorbic and tartaric) and flavonoids (naringin, hesperidin and neohesperidin) were quantified by HPLC, whereas total phenols and the antioxidant capacity were determined by spectrophotometric methods. The UV-C treatments caused a significant decrease (15% to 30%) in ascorbic acid and antioxidant capacity (10% to 27%), which was related to the applied dose. However, no changes (p>0.05) in others organics acids, individual flavonoids, total phenols, pH, °Brix, colour and titratable acidity were observed after UV-C treatment. During the storage at both temperatures, a decrease in the neohesperidin levels (43% - 53%) was detected whereas the others parameters analyzed did not show changes (p>0.05). The microbiological quality of grapefruit juices treated with 3.94 J\/cm² was maintained for 15 and 10 days at 4 and 10º C respectively.","palabras_clave":"non-thermal technology|organic acids|naringin|antioxidant capacity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18541,"idioma_id":4,"titulo":"Emerging ecosystems change the spatial distribution of top carnivores even in poorly populated areas","resumen":"Humans affect biological diversity and species distribution patterns by modifying resource availability and generating novel environments where generalist species benefit and specialist species are rare. In particular, cities create local homogenization while roads fragment habitat, although both processes can increase food availability for some species that may be able to take advantage of this new source. We studied space use by birds of prey in relation to human construction, hypothesizing that these birds would be affected even in poorly populated areas. We worked in Northwestern Patagonia, Argentina, which is experiencing a high population growth, but still having very large unpopulated areas. We related the presence of raptors with different sources of human disturbance and found that both the abundance and richness of these birds were positively associated with anthropogenic environments. These results are driven mostly by a strong association between the medium-sized generalist species and these novel environments (mainly roads and cities). This may create an imbalance in intra-guild competitive abilities, modifying the normal structures of top carnivore hierarchies. Indeed, the structure of raptor communities seems to be changing, even in poorly populated areas, with anthropogenic constructions seemingly producing changes in wild areas more promptly than thought, a cause for concern in ecosystems conservation issues.","palabras_clave":"EMERGING ECOSYSTEMS |RAPTORS|DIVERSITY|ABUNDANCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18542,"idioma_id":5,"titulo":"Herramientas constitucionales para la protección de la costa bonaerense: Caso Mar del Sud, partido de General Alvarado, provincia de Buenos Aires. Argentina","resumen":"La reforma constitucional de 1994, introduce las bases para la protección del medio ambiente como derecho y como deber de cada ciudadano, asimismo establece herramientas de participación y control para la consecución de un desarrollo dentro de un modelo sustentable.   La normativa específica aplicable a la explotación minera en la zona de estudio, revela la necesidad de evaluar su aplicación, según los mandatos constitucionales que determinan el sistema ambiental de protección. A su vez demuestra la importancia del trabajo entre los diferentes estamentos estatales y la necesidad de abordar el caso de manera interdisciplinaria. Por último se suma a este trabajo en conjunto los diferentes sectores sociales involucrados, como los ciudadanos y empresariales.","palabras_clave":"DERECHO CONSTITUCIONAL AMBIENTAL |AMBIENTE LITORAL |MINERIA DE ARIDOS|PARTICIPACIÓN CIUDADANA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18543,"idioma_id":4,"titulo":"Changing epidemiology of HCV genotypes in the central region of Argentina","resumen":"The  aim of this study was to analyze the prevalence of HCV genotypes in Córdoba  province, Argentina, over a 12-year period and to study the changes of the  molecular epidemiological state in this region.          A  recent review indicates that in Latin America, including Argentina, the  genotype 1 is dominant. However, the occurrence of HCV-2c has been reported in  high prevalence in Córdoba.          HCV  genotype was determined in 357 HCV-infected patients. Additionally, the phylogeny  and demographic reconstruction for HCV-1 was assessed in a subset of NS5B and  E2 sequences, respectively.           The  current study has shown a significant reduction in HCV-2  prevalence in Córdoba province, Argentina, after 2003. Thus, HCV-2 was  predominant in patients attending the hospital between 1999 and 2003, whereas  HCV-1 was predominant in the patients attending from 2004 to 2010. These results  are in agreement with a younger most recent common ancestor (1941-1972) for  HCV-1 respect to the previous published data for HCV-2 in Córdoba province,  which was estimated around 1875.          These  findings enhance our understanding about the changing epidemiology of HCV in  Córdoba. Additionally, the differences in the diversity of HCV-1a and HCV-1b  suggest differential characteristics of patients infected with these subtypes  that wait to be addressed. Finally, this study supports the epidemiological  changes observed in South America and Europe. Nevertheless, the consequences of  these changes remain to be elucidated, so as to better understand HCV scenario,  in the present era of the new direct-acting antiviral drugs.","palabras_clave":"Hepatitis C Virus|Genotype|Phylogeny|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18544,"idioma_id":4,"titulo":"Physiological implications of biased signaling at histamine H2 receptors","resumen":"HistaminemediatesnumerousfunctionsactingthroughitsfourreceptorsubtypesallbelongingtothelargefamilyofseventransmembraneG-proteincoupledreceptors.Inparticular,histamineH2receptor(H2R)ismainlyinvolvedingastricacidproduction,becomingaclassicpharmacologicaltargettotreatZollinger?Ellisondiseaseandgastricandduodenalulcers.H2ligandsrankamongthemostwidelyprescribedandoverthecounter-solddrugsintheworld.RecentevidenceindicatethatsomeH2Rligandsdisplaybiasedagonism,selectingandtriggeringsome,butnotall,ofthesignalingpathwaysassociatedtotheH2R.Theaimofthepresentworkistostudywhetherfamotidine,clinicallywidespreadusedligandactingatH2R,exertsbiasedsignaling.OurfindingsindicatethatwhilefamotidineactsasinverseagonistdiminishingcAMPbasallevels,itmimicstheeffectsofhistamineandtheagonistamthamineconcerningreceptordesensitizationandinternalization.Moreover,thetreatmentofHEK293TtransfectedcellswithanyofthethreeligandsleadtoaconcentrationdependentpERKincrement.SimilarlyinAGSgastricepithelialcells,famotidinetreatmentledtoboth,thereductionincAMPlevelsaswellastheincrementinERKphosphorylation,suggestingthatthisbehaviorcouldhavepharmacologicalrelevantimplications.Basedonthat,histidinedecarboxylaseexpressionwasstudiedbyquantitativePCRinAGScellsanditslevelswereincreasedbyfamotidineaswellasbyhistamineandamthamine.Inallcases,thepositiveregulationwasimpededbytheMEKinhibitorPD98059,indicatingthatbiasedsignalingtowardERK1\/2pathwayistheresponsibleofsuchenzymeregulation.Theseresultssupportthatligandbiasisnotonlyapharmacologicalcuriositybuthasphysiologicalandpharmacologicalimplicationsoncellmetabolism.","palabras_clave":"H2R |7TMR|bias|ERK"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18545,"idioma_id":4,"titulo":"N = 2 SUSY Abelian Higgs model with hidden sector and BPS equations","resumen":"In this paper we study a system inspired on certain SUSY breaking models and  on more recent Dark Matter scenarios. In our set-up, two Abelian gauge fields interact via an operator that mixes their kinetic terms. We find the extended Supersymmetric version of this system, that also generates a Higgs portal type of interaction. We obtain and study both analytically and numerically, the equations defining topologically stable string-like objects. We check our results using two different approaches.","palabras_clave":"susy|hidden|visible"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18546,"idioma_id":4,"titulo":"Existence theorems for non-Abelian Chern--Simons--Higgs vortices with flavor","resumen":"In this paper we establish the existence of vortex solutions for a Chern?Simons?  Higgs model with gauge group SU(N) × U(1) and flavor SU(N), these symmetries  ensuring the existence of genuine non-Abelian vortices through a color-flavor locking.  Under a suitable ansatz we reduce the problem to a 2 × 2 system of nonlinear ellip-  tic equations with exponential terms. We study this system over the full plane and  over a doubly periodic domain, respectively. For the planar case we use a variational  argument to establish the existence result and derive the decay estimates of the solu-  tions. Over the doubly periodic domain we show that the system admits at least two  gauge-distinct solutions carrying the same physical energy by using a constrained mini-  mization approach and the mountain-pass theorem. In both cases we get","palabras_clave":"Chern-Simons|Higgs|vortices"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18547,"idioma_id":4,"titulo":"Hippocampal dynamics of synaptic NF-Kappa B during inhibitory avoidance long-term memory consolidation in mice","resumen":"Since the discovery that long-term memory is dependent on protein synthesis, several transcription factors have been found to participate in the transcriptional activity needed for its consolidation. Among them, NF-kappa B is a constitutive transcription factor whose nuclear activity has proven to be necessary for the consolidation of inhibitory avoidance in mice. This transcription factor has a wide distribution in the nervous system, with a well-reported presence in dendrites and synaptic terminals. Here we report changes in synaptosomal NF-kappa B localization and activity, during long-term memory consolidation. Activity comparison of synaptosomal and nuclear NF-kappa B, indicates different dynamics for both localizations. In this study we identify two pools of synaptosomal NF-kappa B, one obtained with the synaptoplasm (free fraction) and the second bound to the synaptosomal membranes. During the early steps of consolidation the first pool is activated, as the membrane associated transcription factor fraction increases and concomitantly the free fraction decreases. These results suggest that the activation of synaptic NF-kappa B and its translocation to membranes are part of the consolidation of long-term memory in mice.","palabras_clave":"I kappa B alpha|NF-kappa B|memory consolidation|synapse"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18548,"idioma_id":4,"titulo":"Trypanosoma cruzi Infection Is a Potent Risk Factor for Non-alcoholic Steatohepatitis Enhancing Local and Systemic Inflammation Associated with Strong Oxidative Stress and Metabolic Disorders","resumen":"The immune mechanisms underlying experimental non-alcoholic steatohepatitis (NASH), and more interestingly, the effect of T. cruzi chronic infection on the pathogenesis of this metabolic disorder are not completely understood. We evaluated immunological parameters in male C57BL\/6 wild type and TLR4 deficient mice fed with a standard, low fat diet, LFD (3% fat) as control group, or a medium fat diet, MFD (14% fat) in order to induce NASH, or mice infected intraperitoneally with 100 blood-derived trypomastigotes of Tulahuen strain and also fed with LFD (I+LFD) or MFD (I+MFD) for 24 weeks. We demonstrated that MFD by itself was able to induce NASH in WT mice and that parasitic infection induced marked metabolic changes with reduction of body weight and steatosis revealed by histological studies. The I+MFD group also improved insulin resistance, demonstrated by homeostasis model assessment of insulin resistance (HOMA-IR) analysis; although parasitic infection increased the triglycerides and cholesterol plasma levels. In addition, hepatic M1 inflammatory macrophages and cytotoxic T cells showed intracellular inflammatory cytokines which were associated with high levels of IL6, IFN&#947; and IL17 plasmatic cytokines and CCL2 chemokine. These findings correlated with an increase in hepatic parasite load in I+MFD group demonstrated by qPCR assays. The recruitment of hepatic B lymphocytes, NK and dendritic cells was enhanced by MFD, and it was intensified by parasitic infection. These results were TLR4 signaling dependent. Flow cytometry and confocal microscopy analysis demonstrated that the reactive oxygen species and peroxinitrites produced by liver inflammatory leukocytes of MFD group were also exacerbated by parasitic infection in our NASH model. We highlight that a medium fat diet by itself is able to induce steatohepatitis. Our results also suggest a synergic effect between damage associated with molecular patterns generated during NASH and parasitic infection, revealing an intense cross-talk between metabolically active tissues, such as the liver, and the immune system. Thus, T. cruzi infection must be considered as an additional risk factor since exacerbates the inflammation and accelerates the development of hepatic injury.","palabras_clave":"STEATOHEPATITITS|INFLAMMATION|TRYPANOSOMA CRUZI|INNATE AND ADAPTIVE IMMUNITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18549,"idioma_id":4,"titulo":"Subcritical Contact Process Seen from the Edge: Convergence to Quasi-Equilibrium","resumen":"The subcritical contact process seen from the rightmost infected site has no invariant measures. We prove that nevertheless it converges in distribution to a quasi-stationary measure supported on finite configurations.","palabras_clave":"Proceso de contacto|convergencia|equilibrio|cuasi-estacionaria"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18550,"idioma_id":4,"titulo":"Finite cycle Gibbs measures on permutations of Z^d","resumen":"We consider Gibbs distributions on the set of permutations of Zd  associated to the Hamiltonian H(&#963;):=&#8721;xV(&#963;(x)&#8722;x), where  &#963; is a permutation and V:Zd&#8594;R is a strictly convex  potential. Call finite-cycle those permutations composed by finite cycles only.  We give conditions on V ensuring that for large enough temperature &#945;&gt;0  there exists a unique infinite volume ergodic Gibbs measure &#956;&#945;  concentrating mass on finite-cycle permutations; this measure is equal to the  thermodynamic limit of the specifications with identity boundary conditions. We  construct &#956;&#945; as the unique invariant measure of a Markov process on  the set of finite-cycle permutations that can be seen as a loss-network, a  continuous-time birth and death process of cycles interacting by exclusion, an  approach proposed by Fern´andez, Ferrari and Garcia. Define &#964;v as the  shift permutation &#964;v(x)=x+v. In the Gaussian case V=&#8741;&#8901;&#8741;2, we  show that for each v&#8712;Zd, &#956;&#945;v given by  &#956;&#945;v(f)=&#956;&#945;[f(&#964;v&#8901;)] is an ergodic Gibbs measure equal  to the thermodynamic limit of the specifications with &#964;v boundary  conditions. For a general potential V, we prove the existence of Gibbs  measures &#956;&#945;v when &#945; is bigger than some v-dependent value.","palabras_clave":"Random perturbation|cycles|loss netwoark|gibbs measures"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18551,"idioma_id":4,"titulo":"Dual Role of cAMP in the Transcriptional Regulation of Multidrug Resistance Associated Protein 4 (MRP4) in Pancreatic Adenocarcinoma Cell Lines","resumen":"Cyclic AMP represents one of the most studied signaling molecules and its role in proliferationand differentiation processes has been well established. Intracellular cAMP levels aretightly regulated where the MRP4 transporter plays a major role. In the present study, wesought to establish whether cAMP modulated MRP4 expression in pancreatic adenocarcinomacell lines. Quantitative PCR and western blot studies showed that cAMP-increasingagents enhanced MRP4 transcripts and protein levels in PANC-1 cells. Reporter luciferaseexperiments carried out in pancreatic AR42J cells showed that intracellular cAMP up-regulatesMRP4 through an Epac2- and Rap1- mediated mechanism whereas extracellularcAMP reduced MRP4 promoter activity by a MEK\/ERK-mediated pathway. Present resultsshow that cAMP regulates MRP4 promoter activity, and further indicate that the balance betweenintracellular and extracellular cAMP levels determines MRP4 expression.","palabras_clave":"MULTIDRUG RESISTANCE PROTEINS|MRP4|EXPRESSION|PDAC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18552,"idioma_id":5,"titulo":"Estudio de la comunidad de parásitos gastrointestinales de guanacos silvestres (Lama guanicoe) de la Reserva Provincial La Payunia, Argentina","resumen":"Los vertebrados silvestres albergan comunidades parasitarias compuestas por varias especies, pero la estructura natural de estas comunidades se está viendo afectada en la actualidad por la fragmentación de hábitat e introducción de especies exóticas. El objetivo de este trabajo fue identificar a las especies de parásitos gastrointestinales presentes en la población migratoria de guanacos silvestres de la Reserva Provincial La Payunia (Mendoza), mediante la identificación de las formas evolutivas presentes en la materia fecal. Se analizaron las heces de 756 individuos, colectadas entre los años 2009 y 2012. La comunidad parasitaria gastrointestinal de esta población de guanacos estuvo compuesta por al menos 11 especies. Los parásitos pertenecieron a 5 especies de nematodes: 2 de Nematodirus, 1 de Trichuris, 1 de Capillaria y 1 de Strongyloides; 1 especie de cestode correspondiente a Moniezia benedeni, y 5 especies de protozoos del género Eimeria (E. lamae, E. alpacae, E. punoensis, E. macusaniensis y E. ivitaensis). Nematodirus spp., Strongyloides sp., y Moniezia benedeni son parásitos propios de rumiantes domésticos y su presencia refleja la susceptibilidad del guanaco, por lo que se recomienda realizar monitoreos parasitológicos periódicos, a fin de poder anticiparse ante incrementos importantes en este tipo de parasitismo en los guanacos silvestres.","palabras_clave":"Bovino|Lama guanicoe|Ovino|Parásitos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18553,"idioma_id":4,"titulo":"Counter-ion and solvent effects on the acidity of calix[4]arene and para-tert-butylcalix[6]arene","resumen":"Spectrophotometric titrations of calix[4]arene and p-tert-butylcalix[6]arene with LiOH, NaOH, KOH, tetramethylmmonium and tetrabutylammonium hydroxides as bases were carried in ethanol 95 % and acetonitrile. The dependence of pKa of the first deprotonation of calix[4]- arene with the nature of the cation was only modest in ethanol 95 %, spanning from 8.53 pKa unit for NaOH until 9.00 for LiOH, whereas in acetonitrile the proton transfer is quantitative. The first deprotonation of p-t-butylcalix[6]arene in both solvents is quantitative and the extension of the second deprotonation is very dependent of the nature of the cation in ethanol and acetonitrile. Tetramethylammonium hydroxide was the strongest base for both solvents, and both deprotonations proceed quantitatively and concomitantly in ethanol, followed by potassium hydroxide, and the weakest base was tetrabutylammonium hydroxide. This behavior indicates that the ability to form N+-C?H?p and K+?p interactions plays an important role to stabilize the mono and dianion calixarene. Lithium and sodium exhibit non-usual acid?base behavior in acetonitrile, attributed to aggregation of the species.","palabras_clave":"Calixarenes  |Solvent effects|pKa |Supramolecular chemistry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18554,"idioma_id":4,"titulo":"Clinical activity of ponatinib in one patient with chronic myeloid leukemia in chronic phase with e19a2 transcript and T315I mutation","resumen":"BACKGROUND:Chronic myeloid leukemia (CML) is a hematological disorder that in rare cases, mainly in CML neutrophilic, presents the e19a2 rearrangement. The encoded product is a 230-KDa protein. Despite the remarkable responses to treatment of most patients, a small but significant fraction of them develop clinical resistance to the tyrosine kinase inhibitors (TKIs). The most common mechanism of resistance is point mutations in the ABL1 kinase domain. The recently approved third-generation TKI ponatinib demonstrated remarkable activity in patients with multi-TKI-resistant disease. Particularly impressive was its efficacy in patients with T315I mutation that is resistant to all other TKIs.METHODS:Qualitative PCR was carried out by multiplex approach. Relative transcripts quantification was performed by one-step real-time PCR, with a specific Taqman probe and primers for the e19a2 rearrangement. We carried out a mutational screening by high-resolution melting, and the mutation was identified by Sanger method. The mutation burden was quantified by quantitative PCR using allele-specific primers.RESULTS:In a patient with CML, we identified a PCR product corresponding to e19a2 rearrangement harboring T315I mutation. At the time of mutational analysis, during dasatinib treatment, the T315I clone was 100% and the quantification of BCR-ABL1 was 18%. After ponatinib therapy, the T315I mutation burden decreased down to undetectable levels and the BCR-ABL1 transcripts showed a very low value (0.011%).CONCLUSIONS:Here, we report the hematological, cytogenetic, and molecular response of a patient with refractory CML in chronic phase with e19a2 transcripts, carrying T315I mutation that was successfully treated with ponatinib.","palabras_clave":"ponatinib|leucemia|mutaciones"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18555,"idioma_id":4,"titulo":"Obtaining classification rules using lvqPSO","resumen":"Technological advances nowadays have made it possible forprocesses to handle large volumes of historic information whose man-ual processing would be a complex task. Data mining, one of the mostsignicant stages in the knowledge discovery and data mining (KDD)process, has a set of techniques capable of modeling and summarizingthese historical data, making it easier to understand them and helpingthe decision making process in future situations. This article presents anew data mining adaptive technique called lvqPSO that can build, fromthe available information, a reduced set of simple classication rules fromwhich the most signicant relations between the features recorded canbe derived. These rules operate both on numeric and nominal attributes,and they are built by combining a variation of a population metaheuristicand a competitive neural network. The method proposed was comparedwith several methods proposed by other authors and measured over 15databases, and satisfactory results were obtained.","palabras_clave":"CLASSIFICATION RULES|DATA MINING|ADAPTIVE STRATEGIES|PARTICLE SWARM OPTIMIZATION|LEARNING VECTOR QUANTIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18556,"idioma_id":5,"titulo":"Entre el deductivismo y la hermenéutica, la abeja y la mosca no son bichos","resumen":"El título de esta Perspectiva remeda el título de una película argentina de los años ?60, ?La cigarra no es un bicho?, una película de picaresca, cándida a los ojos de un espectador actual, que mostraba el erotismo permitido y tolerable para la censura de la época. En este caso ?La cigarra? no nombraba a un insecto sino a un hotel alojamiento porteño donde, en la trama, los huéspedes se ven obligados a permanecer en cuarentena a causa de una infección de peste bubónica que instala un marinero francés creando con ello todo tipo de situaciones que ponen en descubierto los tabúes y prejuicios sociales de la época. De mismo modo y abusando de la ambigüedad del lenguaje, ?la abeja? y ?la mosca? a las que nos hemos de referir no son bichos, no son los insectos que conocemos, sino que son los nombres de dos íconos con los que identificaremos distintas vertientes epistemológicas, normalmente consideradas antagónicas: el deductivismo y la hermenéutica.  En principio debemos aclarar que hemos elegido a estas dos figuras dentro de un zoológico epistemológico que hemos ido recolectando y catalogando durante varios años de intenso trabajo intercátedras en dos materias de CBC (Biología e Introducción al Pensamiento Científico) ya que en el esfuerzo por hacer accesibles los pensamientos y conceptos de la Biología y de la Epistemología, en nuestro trabajo cotidiano de enseñanza universitaria, especialmente motivada por la necesidad de acercar la epistemología a la ciencia y la ciencia a la epistemología, buscamos figuras, símbolos y modelos para caracterizar aquellas situaciones que de modo puramente conceptual resultan de difícil comprensión. En este camino llegamos a conformar una especie de bestiario donde ?el gato?, ?el cisne?, ?el pavo?, ?el pato-conejo?, ?la mosca?, ?la abeja?, ?el ornitorrinco?, ?el gatopardo inverso?, son animales que no responden a la zoología, son el modo de nombrar a entidades que nos permiten identificar conceptos epistemológicos indicativos de situaciones o problemas ligados a la construcción y validación de teorías científicas (Alonso-Ambrosini-Beraldi, 2014). Aquí se admite que estas metáforas no son solamente formas subsidiarias del lenguaje que luego deben ?traducirse? a otro lenguaje original, neutro y transparente, sino que ellas tienen un valor epistémico, y son constitutivas en la producción del conocimiento que luego apropian los estudiantes. En base a este supuesto, no tiene sentido advertir o denunciar acerca de los supuestos peligros de su uso, sino por el contrario, se trata de reconocer las posibilidades y las potencialidades de estas figuras para comprender mejor los compromisos epistemológicos que subyacen a la adjudicación de significados en la construcción de las teorías científicas. A partir de esta capacidad de la metáfora para construir similitudes y de presentar una estructura coherente de ideas se reconoce que tienen un valor cognoscitivo. Replicando una idea ya presente en Kuhn respecto a los paradigmas (Kuhn, 1986), podemos decir que las metáforas o analogías de este tipo son como ?lentes? o ?anteojos? a través de las cuales vemos el mundo. Así, antes de presentar a la abeja y a la mosca como ?lentes? a través de los cuales caracterizar dos vertientes epistemológicas tradicionalmente presentadas como rivales, expondremos algunas ideas de la epistemología contemporánea a las que adherimos al momento de justificar el uso de estas metáforas en nuestra tarea docente.","palabras_clave":"HERMENEUTICA|EPISTEMOLOGIA|ANIMALES|ETICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18557,"idioma_id":4,"titulo":"CARDIOPROTECTION OF HYPERTHYROIDISM ON THE STUNNED RAT HEART UNDER ISCHAEMIA\/REPERFUSION: ENERGETICS AND ROLE OF MITOCHONDRIA","resumen":"ABSTRACT    Aim:  Angor is a frequent death risk and it could be worsen by hyperthyroidism because of adrenergic exacerbation. The influence of hyperthyroidism on the cardiac stunning consequent to ischaemia\/reperfusion (I\/R) and the mitochondrial role were studied.    Methods:   rats were injected s.c. with 20 &#956;g.kg-1 T3 by day during 15 days (HpT). Isolated  perfused hearts from HpT or euthyroid (EuT) rats were introduced in a calorimeter for simultaneously measuring left intraventricular pressure (LVP, mmHg) and heat release (Ht, mW.g-1). Stunning was evoked by 20 minutes no-flow I and 45 minutes R and drugs were perfused before I.    Results:  HpT hearts developed higher postischaemic contractile recovery (PICR) and  improved total muscle economy (P\/Ht) with lower diastolic contracture (FLVEDP) than Eu hearts. Release of sarcorreticular (SR) Ca2+ during R with 10 mM caffeine in low [Na]o-Krebs evoked similar contracture but faster in Eu than HpT. Blockade of mNCX with clonazepam (Clzp) increased FLVEDP and reduced P\/Ht and PICR in HpT (13±3.8%) but not in Eu (98±14%). Clzp dysfunction in HpT was reduced by cyclosporin A (Cys-A) suggesting that it depends on mPTP opening. Blockade of UCam with Ru360 reduced P\/Ht and PICR to about 10% in both HpT and Eu. Blockade of mKATP with 5HD increased LVEDP and reduced PICR and P\/Ht in HpT while it only increased LVEDP in Eu.    Conclusions:   HpT prevented stunning with higher dependence on mNCX and mKATP than EuT. Both show critical role for UCam. HpT hearts have a slow SR Ca2+ loss and reduced mitochondrial Ca2+ uptake.","palabras_clave":"CALCIUM|CALORIMETRY|CARDIOPROTECTION|HYPERTHYROIDISM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18558,"idioma_id":4,"titulo":"Obtaining classification rules using LVQ +PSO: An application to credit risk","resumen":"Credit risk management is a key element of financial corporations. One of the main problems that face credit risk officials is to approve or deny a credit petition. The usual decision making process consists in gathering personal and financial information about the borrower. This paper present a new method that is able to generate classifying rules that work no only on numerical attributes, but also on nominal attributes. This method, called LVQ+PSO, combines a competitive neural network with an optimization technique in order to find a reduced set of classifying rules. These rules constitute a predictive model for credit risk approval. Given the reduced quantity of rules, our method is very useful for credit officers aiming to make decisions about granting a credit. Our method was applied to two credit databases that were extensively analyzed by other competing classification methods. We obtain very satisfactory results. Future research lines are exposed.","palabras_clave":"CREDIT RISK|CLASSIFICATION RULES|LEARNING VECTOR QUANTIZATION|PARTICLE SWARM OPTIMIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18559,"idioma_id":4,"titulo":"Invariant solutions to the conformal Killing-Yano equation on Lie groups","resumen":"We search for invariant solutions of the conformal Killing-Yano equation on Lie groups equipped   with left invariant Riemannian metrics, focusing on $2$-forms. We show that when the Lie group is   compact equipped with a bi-invariant metric or $2$-step nilpotent, the only invariant solutions   occur on the $3$-dimensional sphere or on a Heisenberg group. We classify the $3$-dimensional Lie   groups with left invariant metrics carrying invariant conformal Killing-Yano $2$-forms.","palabras_clave":"Conformal Killing-Yano tensor|Lie group|Left invariant metric"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18560,"idioma_id":4,"titulo":"Nutritional profile and Obesity: results from a random sample population-based study in Córdoba, Argentina.","resumen":"Eur J Nutr. 2015 Mar 31. [Epub ahead of print]  Nutritional profile and obesity: results from a random-sample population-based study in Córdoba, Argentina.  Aballay LR1, Osella AR, De La Quintana AG, Diaz MD.  Author information  Abstract  INTRODUCTION:  Obesity is a chronic, heterogeneous, multifactorial disease, which has sharply increased in prevalence in both developed and developing countries. This study aimed to estimate the prevalence of obesity and to identify socio-demographic risk factors associated with it, with special emphasis on diet.  METHODS:  Nutritional status, demographic characteristics, lifestyle habits, and food consumption patterns derived from a Food Frequency Questionnaire were investigated. Exhaustive exploratory analyses were performed in order to describe dietary patterns, and logistic regression models were used for odds ratio estimation.  RESULTS:  The study included 4328 subjects, over 18 years old and resident in Cordoba city. The prevalence of overweight and obesity was 34 and 17 %, respectively, with 60 % in men and 45 % in women of BMI &#8805; 25. Obesity risk factors were high intake of sodium, refined grains, starchy vegetables, and snacks. A lower risk of overweight and obesity was associated with an adequate, moderate intake of meats, eggs, alcoholic beverages, sugar and sweets, milk, yogurt, and pulses.  CONCLUSIONS:  A high intake of snacks, refined grains, starchy vegetables and sodium and low intake of yogurt, milk, pulses, and whole grains seem to be associated with the emergence and high prevalence of obesity in Cordoba, Argentina.","palabras_clave":"Overweight | Obesity |Argentina |Odds ratio | Logistic regression"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18561,"idioma_id":4,"titulo":"Nanofiltration of glucose: analysis of parameters and membrane characterization","resumen":"Membrane characterization and modeling of nanofiltration processes of uncharged solutes are of special interest for the food industry. In this work two commercial membranes, DK and DL, were used to concentrate glucose solutions. Membranes were characterized according hydrophobicity, thickness, porosity, and hydraulic permeability. The influence of pressure and concentration of glucose on the permeate flux and rejection were studied. Both membranes presented a great potential for the food industry due to their high rejection of glucose. The osmotic pressure model was combined with film theory and the real driven force was calculated taking into account the osmotic pressure and the concentration polarization. Both phenomena influenced the process (concentration polarization only in the most dilute solutions at low pressure) and the permeability for glucose solutions was similar to the hydraulic permeability. A mathematical model based on the Donnan- Steric Pore Model was used to determine the pore radius and the effective thickness of both membranes. As the concentration inside the pore (needed for the calculations) is difficult to measure experimentally, various alternatives were proposed. The average of the concentration at the interface and permeate best fitted the experimental data. The model was applied successfully; the maximum error was 8% within the range of concentrations (5?100 g\/L) for the DL membrane and 5% for the DK membrane up to 50 g\/L.","palabras_clave":"Nanofiltration|Glucose|Concentration Polarization|DSPM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18562,"idioma_id":4,"titulo":"Removal of vegetable tannins to recover water in the leather industry by ultrafiltration polymeric membranes","resumen":"The leather tanning industry consumes large amounts of water and produces, consequently, significant volumes of wastewater with high concentration of chemicals and organic matter. One of the main chemicals present in effluents is the vegetable tannin, which causes a severe environmental impact. With the aim of predicting the performance in chemicals separation of two ultrafiltration (UF) polymeric membranes (OT050 and GR60PP) for potential use in the purification of the waste stream of vegetable tanning liquors, a synthetic wastewater was prepared. Trials were carried out at laboratory scale using a flat cell with an effective area of 0.004 m2. The effect of transmembrane pressure in the permeate flux was studied. Flux decline, fouling resistance and fouling index of the membranes were analyzed. The efficiency of different membranes was assessed using the rejection coefficient for tannins, non-tannins and total solids. Analysis of the wastewater treated by UF showed 98% of tannin retention and a recovery of the water flux after cleaning the membrane GR60PP with water of 43 to 45%. The rejection coefficient observed for the GR60PP membrane was higher than for the OT050. There are no previous studies related to the removal of vegetable tannins in exhausted vegetable tanning bath by using UF polymeric membranes. This study sets a precedent because the results obtained are very promising regarding permeate flux and rejection observed.","palabras_clave":"Tannery wastewater|Ultrafiltration|Water reuse|Fouling"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18563,"idioma_id":4,"titulo":"Active wind noise hybrid control in motorcycle helmets","resumen":"In this work, three experiments are conducted. In a realistic environment (freeway), a database for the noise dynamics vs. velocity in a motorcycle helmet is computed. Next, under the controlled conditions of an anechoic chamber, the models for the feedback (FB) and feedforward (FF) paths in the helmet are obtained by a ltering and identication process. Finally, in the same chamber, a hybrid  (FB+FF) robust controller is tested against the actual noise measured in the  freeway, and it achieves attenuations between 20 and 30 dB.","palabras_clave":"Motorcycle helmets|Active noise control|H-infinity optimal control|Feedforward"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18564,"idioma_id":4,"titulo":"Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth","resumen":"Thyroid hormones (THs) are important regulators of cell physiology. They are essential for the normal development and growth of mammals, especially for the neural differentiation and the regulation of the metabolism and the immune system. THs also induce the proliferation of several cell types. In human and murine T cell lymphomas (TCL) this effect involves the participation of genomic and nongenomic mechanisms as it was described by the use of free THs and non-cell permeable THs coupled to agarose (TH-ag). The classic actions of thyroid hormones involve the alteration of gene transcription via specific nuclear receptors. The discovery of other effects, independent of this classic mechanism, characterizes a new and non-classic mechanism that involves different signaling pathways. Both, free THs and TH-ag, activate protein kinase C, extracellular signal-regulated kinases and NF-kB and they increase the intracellular calcium levels. However, only the preincubation of T cells with free THs leads to an increased intracellular content of signaling enzymes. T lymphomas display high expression levels of both, the TH nuclear receptors (TRs) and the putative membrane receptor for THs, the integrin alphaVbeta3, which has been demonstrated to be responsible for THs non-genomic actions. Here, we reviewed the mechanisms involved in THs modulation of the lymphocyte physiology, analyzing the interplay between genomic and nongenomic actions in T cells and its contribution in the development of lymphomas.","palabras_clave":"GENOMIC SIGNALING|INTEGRIN |NONGENOMIC SIGNALING|THYROID HORMONES|T CELL LYMPHOMA|TUMOR GROWTH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18565,"idioma_id":4,"titulo":"Molecular diagnosis of natural fasciolosis by DNA detection in sheep faeces","resumen":"Fasciolosis is an important parasitic zoonosis considered the most important helminth infection of ruminants in tropical countries. The aim of this study was to develop a PCR assay for the sensitive and specific detection of F. hepatica in formalin preserved sheep faeces. A 405-bp fragment of the cytochrome c oxidase subunit 1 gene of F. hepatica was amplified from stool samples of infected sheep. The PCR assay showed a detection limit of 20 pg of F. hepatica DNA. No cross-reactions were observed with samples containing coccidian oocysts or  gastrointestinal nematodes eggs. Our PCR technique showed to be effective for specific detection of F. hepatica infections in sheep.","palabras_clave":"FASCIOLA HEPATICA |PCR |DIAGNOSIS |FAECES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18566,"idioma_id":4,"titulo":"Best Simultaneous Lp-Approximation on Small Regions","resumen":"In this paper we study the behavior of best simultaneous Lp-approximationby algebraic polynomials on a union of intervals, when the measure of them tend to zero. We also get an interpolation result.","palabras_clave":"Algebraic polynomials|Lp-spaces|Simultaneous approximation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18568,"idioma_id":4,"titulo":"Chronic Treatment with Atrial Natriuretic Peptide in Spontaneously Hypertensive Rats: Beneficial Renal Effects and Sex Differences","resumen":"OBJECTIVE: The aim of this study was to investigate the effects of chronic treatment with atrial natriuretic peptide (ANP) on renal function, nitric oxide (NO) system, oxidative stress, collagen content and apoptosis in kidneys of spontaneously hypertensive rats (SHR), as well as sex-related differences in the response to the treatment.  METHODS:  10 week-old male and female SHR were infused with ANP (100 ng\/h\/rat) or saline (NaCl 0.9%) for 14 days (subcutaneous osmotic pumps). Systolic blood pressure (SBP) was recorded and diuresis and natriuresis were determined. After treatment, renal NO synthase (NOS) activity and eNOS expression were evaluated. Thiobarbituric acid-reactive substances (TBARS), glutathione concentration and glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were determined in the kidney. Collagen was identified in renal slices by Sirius red staining and apoptosis by Tunel assay.  RESULTS:  Female SHR showed lower SBP, oxidative stress, collagen content and apoptosis in kidney, and higher renal NOS activity and eNOS protein content, than males. ANP lowered SBP, increased diuresis, natriuresis, renal NOS activity and eNOS expression in both sexes. Renal response to ANP was more marked in females than in males. In kidney, ANP reduced TBARS, renal collagen content and apoptosis, and increased glutathione concentration and activity of GPx and SOD enzymes in both sexes.  CONCLUSIONS:  Female SHR exhibited less organ damage than males. Chronic ANP treatment would ameliorate hypertension and end-organ damage in the kidney by reducing oxidative stress, increasing NO-system activity, and diminishing collagen content and apoptosis, in both sexes.","palabras_clave":"ATRIAL NATRIURETIC PEPTIDE|CHRONIC TREATMENT|KIDNEY|SEX DIFFERENCES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18569,"idioma_id":4,"titulo":"Distribution of Ophioglossum reticulatum L. in South America. A Case of long-distance jump dispersal?","resumen":"The objective of this exploratory work is to test the hypothesis that South American populations of Ophioglossum reticulatum L. derive from Africa. Spores cross the Atlantic transported by the wind and arrive in South America in recurrent migration. Three-dimensional (backward and forward) trajectories of spores between Africa and South America were calculated using the Hybrid Single Particle Lagrangian Integrated Trajectory Model (HYSPLIT4). The model showed possible backward trajectories in the low troposphere arriving in South America with probable origin in Northwestern Africa. The results support the hypothesis of long distance dispersal of the studied species. Including vertical motion in the model runs allowed obtaining valuable and novel information about the migration routes. The trade winds combined with the South American monsoon could be a dispersal vehicle for the disseminules from Northwestern Africa to the eastern slopes of the Andes. As the Monsoon is a periodic regional atmospheric circulation pattern, transcontinental migration can be assumed to be a recurring phenomenon that provides genetic exchange and prevents speciation by reproductive isolation. Modelled forward trajectories connect the neotropics with Africa-Madagascar but they seem to be less effective due to their travelling altitudes. This hypothesis might explain the absence of infraspecific taxa restricted to different geographic locations.","palabras_clave":"jump dispersal|recurrent migration|disseminules|ferns|monsoon|low level jet"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18570,"idioma_id":4,"titulo":"The circumscription of problematic species of Ophioglossum (Ophioglossaceae) from Southern South America: a palynological approach","resumen":"      Abstract:  The genus Ophioglossum has around 25  species that occurs nearly worldwide. This genus  has historically posed a number of problems for taxonomists because of the lack  of morphological characters upon which to base species delimitations. The  sculpture pattern of spore of ten critical taxa of the genus Ophioglossum is analyzed, in an attempt to  delimit the conflicting species into the genus from Southern   South America. The palynological data was compared with the  morphology of the sporophyte and type specimens. The sculpture pattern was the  most valuable and consistent taxonomic character upon which to base species  delimitation. In this region the name Ophioglossum  melipillense is reinstated, and the other species recognized to the genus Ophioglossum s.s. are the following  species: O. crotalophoroides, O. nudicaule,  O. opacum, and O. vulgatum. The  name O. lusitanicum is excluded from  the studied area. Ophioglossum  fernandezianum appears to be a doubtful species. In addition, the lectotype  of Ophioglossum lusitanicum is  designated, and the new synonymy is presented.         ","palabras_clave":"OPHIOGLOSACEAE|SOUTH AMERICA|SISTEMATIC|SPORES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18571,"idioma_id":4,"titulo":"Stability of food grade antioxidants formulation to use as preservatives on stored peanut","resumen":"The aim of this study was to microencapsulate butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) by complex coacervation using gelatin-gum arabic system as encapsulating agent under different reticulation conditions (with or without crosslinking agent). Morphology, encapsulation efficiency (%EE) and permanence period of compounds in formulation at 25 C and in peanut grainsstored at different temperatures (20, 25 and 30 C) and water activities (0.65, 0.75, 0.85 and 0.95) were evaluated. Significant statistically differences were observed between crosslinking agents, where microcapsules reticulated with glutaraldehyde were 19% and 21% higher than microcapsules with formaldehyde and without crosslinking agent. Microencapsulation technique used gave about 80 %EE for both antioxidants, regardless of reticulation condition. Permanence of both antioxidants was between 14.4 and 4.6 mg\/g in the formulation stored at 25 C during 30 days and between 730 and 350 ng\/g for BHA and BHT, respectively, in peanut system, after 40 days. This methodology is a promising technique for the addition of food grade antioxidants to peanut providing preservative effects for a storage period greater than 40 days, being and alternative for control of mould, mycotoxins and insects in peanut grains.","palabras_clave":"COMPLEX COACERVACIÒN|BUTYLATED HIDROXYANISOLE|BUTILATED HIDROXYTOLUENE|MICROCAPSULES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18572,"idioma_id":4,"titulo":". The Lucilia group (Asteraceae, Gnaphalieae): phylogenetic and taxonomic considerations based on molecular and morphological evidence.","resumen":"The Lucilia group sensu Anderberg and Freire comprises nine South American genera: Belloa, Berroa, Chevreulia, Cuatrecasasiella, Facelis, Gamochaetopsis,Jalcophila, Lucilia and Luciliocline. The aims of this  contribution were, using DNA sequences from plastid(rpl32-trnL, trnL-F) and nuclear (ITS and ETS) markers,together with morphological characters, to test the monophyly of the Lucilia group and provide new insight into  generic circumscriptions. Our studies, including a broad taxon sampling of Gnaphalieae species, suggest that the Lucilia group is paraphyletic, since Antennaria, Chionolaena,Gamochaeta, Loricaria, Micropsis, Mniodes and Stuckertiella are all nested within the Lucilia group. Morphology  and molecular analyses combined showed that the traditional generic circumscription of most of the genera (e.g., Berroa, Chevreulia, Chionolaena, Cuatrecasasiella,Facelis, Jalcophila and Micropsis) correlates with the inferred phylogenetic relationships. Conversely, Lucilia and Luciliocline are non-monophyletic. Lucilia is nested in  a clade with Berroa, Facelis and Micropsis. Luciliocline is strongly embedded within the clade Belloa pp ? Mniodes. Our results are consistent with Dillon?s study that considered Belloa as a montotypic genus (B. chilensis). Luciliocline and the remaining species of Belloa are  accommodated in the genus Mniodes, and the necessary combinations are proposed for the expanded Mniodes. All the analyses showed that the monotypic genera Stuckertiella and Gamochaetopsis are in a well-supported clade nested within Gamochaeta, which implies that taxonomic  changes are required also for these genera. Internal relationships  in the group and the key morphological characters used in the taxonomy of the group, as well as incongruences found between morphological and molecular analyses, are discussed.","palabras_clave":"BELLOA|ETS|ITS|MNIODES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18573,"idioma_id":4,"titulo":"Selection of potential biological control of Exserohilum turcicum with epiphytic microorganisms from maize","resumen":"The aims of this study were to select microbial isolates from phyllosphere of maize and to examine their antagonistic activity against Exserohilum turcicum. Selection was performed through the ability of isolates to compete with the pathogen using an index of dominance and to affect growth parameters of E. turcicum. Most of the epiphytic populations obtained for the screening were bacteria. These isolates were found in the order of 6 log CFU\/g of leaf fresh weight. According to similar  morphological characteristics and staining, 44 out of 111 isolates obtained were  selected for testing antagonistic effects. At water potential, -1.38 MPa and -4.19 MPa, three Bacillus isolates showed dominance at a distance (5\/0) and a signi&#64257;cant reduction of the pathogen. Three Bacillus isolates only decreased the growth rate of E. turcicum of growth rate -1.38 MPa. At -4.19 MPa the growth rate decreased with three isolates of Pantoea  and three Bacillus. In this study a negative and signi&#64257;cant correlation was observed between the growth rate of E. turcicum and the dominance index in the interaction of the pathogen with some bacteria. These results show that with decreasing growth rate of the pathogen the dominance index of the interaction increases. Eleven potential biocontrol agents against E. turcicum were selected.","palabras_clave":"EXSEROHILUM TURCICUM|BIOCONTROL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18574,"idioma_id":5,"titulo":"?Actores, políticas e instituciones en dos espacios fronterizos chaqueños: la frontera santiagueña y el litoral rioplatense entre 1630-1800?","resumen":"Los estudios tradicionales sobre espacios fronterizos han tendido a realizar un relato muy ajustado a las políticas oficiales que llevó a marcar dos momentos muy definidos: las reformas borbónicas y las revoluciones de independencia.De igual manera, se ha tendido a centrar los estudios en torno a las jurisdicciones administrativas de los espacios fronterizos.El objetivo de este trabajo es matizar ambos postulados tomando como estudio de caso las fronteras santiagueña y litoral chaqueño. Intentaremos mostrar, por un lado, que la dinámica fronteriza no siempre parece depender tan estrechamente de las políticas hispano criollasy que, por otro lado, las fronteras correntina, santafesina y santiagueña aparecen bastante integradas más allá de su pertenencia  a gobernaciones \/ intendencias diferentes.","palabras_clave":"frontera|misiones|gobierno local|indigenas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18575,"idioma_id":4,"titulo":"Live fuel moisture content and leaf ignition of forest species in Andean Patagonia, Argentina","resumen":"Wildfires are common from summer to early fall in Patagonian forests of Argentina. Live fuel moisture content (LFMC) and leaf ignition are important factors for understanding fire behavior. In this study, we determined seasonal LFMC and leaf ignition of some key fire-prone species of these forests, and their relationships with environmental variables. Species investigated were the native trees ñire (Nothofagus antarctica) and cypress (Austrocedrus chilensis), the understory tree-like radal (Lomatia hirsuta) and laura (Schinus patagonicus), the bamboo caña colihue (Chusquea culeou), and the non-native black poplar (Populus nigra). LFMC differed among species, with caña colihue having lower values (LFMC &lt; 100%), ñire, laura, cypress, and radal having medium values (LFMC from 110 to 220%), and black poplar the upper values (LFMC &gt; 220%).&nbsp; Ignition characteristics differed among species (caña colihue&gt; ñire&gt; radal&gt; cypress&gt; laura&gt; black poplar) and were inversely related to LFMC. Correlations between LFMC and environmental variables were highly significant for caña colihue, significant for ñire, radal, and laura, and weakly or non significant for cypress and black poplar.&nbsp;&nbsp; These results contribute to our understanding of fire behavior and to validate the fuel typology for Patagonian forests.&nbsp; At the same time, they add some useful knowledge for comparison with other fire-prone Mediterranean ecosystems around the world.&nbsp;","palabras_clave":"PATAGONIAN FORESTS|WILDFIRES|FOLIAR MOISTURE|FIRE BEHAVIOR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18576,"idioma_id":4,"titulo":"Description of a proctodeal gland present in three South American Liolaemus lizards (Iguania: Liolaemidae)","resumen":"Vertebrates, with the exception of mammals and teleosteos, have a cavity where the products of urogenital and digestive tracts are received and expelled, the cloaca. Moreover, evidence indicate that in different lizard species the cloaca might contain glands with secretions involved in chemical communications, considering that feces are a source of scents. In Liolaemus lizards, feces of both sexes contain information about the owner, allowing self-recognition. Presently, some cloacal glands have been described in the urodeaum of females of two Liolaemus species, which would be involved in process the eggs production and maintenance, although this does not preclude that their products can be used in chemical communication. However, so far there is no information if males of Liolaemus lizards do have glands in the cloaca that might explain the pheromonal properties of feces. Here we explored the anatomy of the anterior border of the cloaca, the proctodeal region, of males and females, juveniles and adults of three Liolaemus species. We found that only males, juveniles and adults, of the three Liolaemus species have an undescribed gland for Liolaemus lizards. This is a compound tubuloacinar gland with apocrine secretion, and its secretory activity depends on the individual?s age, being highest in adult males. Presently, it is unclear if this new discovered gland in Liolaemus males corresponds to any of those previously described in other lizard species. In addition, there is no hint on the specific function of these glands in Liolaemus, although we postulate that their secretions may be involved in reproductive aspects","palabras_clave":"CLOACAL GLAND|HISTOLOGY|HISTOCHEMESTRY|LIZARDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18577,"idioma_id":4,"titulo":"Improvement of the Insecticidal Capacity of Two Purpureocillium Lilacinum Strains against Tribolium Confusum","resumen":"Entomopathogenic fungi can regulate insect populations. They have extracellularenzymes that degrade cuticle components, mainly hydrocarbons, used as an energy source. Theincrease in insecticidal activity of fungi in a medium supplemented with cuticular hydrocarbonswas assayed and the hydrolytic enzyme profiles of two strains of Purpureocillium lilacinumwere evaluated. A spore suspension of P. lilacinum was inoculated in Petri plates with differentvalues (0.99?0.97?0.95) of water activity (Aw) using the substrates gelatin, starch andtween-20. Growth rate on the different substrates and the enzymatic activity index for proteases,amylases and lipases at different incubation times, pH and Aw, was evaluated. Moreover,the insecticidal efficiency of strains grown in media supplemented with n-hexadecane andn-octacosane was analyzed. LT50 was calculated against adults of Tribolium confusum andshowed that mortality increased about 15% when the strains grew in amended culturemedium. High amylolytic activity was detected, but proteases were the main enzymesproduced. Optimal protease production was observed in a range of acid and alkaline pH andlower Aw. The greatest growth rate was obtained in presence of gelatin. Lipase and amylaseproduction was detected in small amounts. Fungal growth in media with hydrocarbon mixturesincreased the pathogenicity of the two strains of P. lilacinum, with the strain JQ926223 beingmore virulent. The information obtained is important for achieving both an increase ininsecticidal capacity and an understanding of physiological adaptation of the fungus.","palabras_clave":"Entomopathogenic fungi|Insects|Enzymes|Virulence"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18578,"idioma_id":5,"titulo":"Resumen de Investigación: LA INSERCIÓN DE LOS GRADUADOS 2011 y 2012 DE LA UNIVERSIDAD NACIONAL DE LA MATANZA EN EL MERCADO LABORAL","resumen":"Hoy, el seguimiento de graduados debe formar parte del Plan Estratégico de la Universidad. La necesidad de conocer en dónde se encuentran los graduados, qué actividades realizan, en dónde se están desarrollando laboralmente y sus intereses de formación son datos claves a la hora de planificar el curso de las actividades académicas en el interior de la Institución. Es por esto que a través de esta Investigación se intenta conocer el panorama de los graduados 2011 y 2012 de la Universidad Nacional de La Matanza.","palabras_clave":"INSERCIÓN LABORAL|GRADUADOS|UNLaM|MERCADO LABORAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18579,"idioma_id":4,"titulo":"Novel topical formulation for ischemic chronic wounds. Technological design, quality control and safety evaluation","resumen":"Ulceration of the foot in diabetes is common and disabling, and frequently leads to amputation of the leg. The pathogenesis of foot ulceration is complex, clinical presentation variable and  management requires early expert assessment. Despite treatment, ulcers readily become chronic wounds. Chronic wounds are those that remain in a chronic inflammatory state failing a normal healing process patterns. This is partially caused by inefficient eradication of opportunistic  pathogens like Pseudomonas aeruginosa. We propose its control or eradication will promote wound healing. Lactobacillus plantarum cultures supernatants (LAPS) shows antipathogenic and pro-healing properties. The main objective was to design two pharmaceutical dosage forms by using LAPS as active pharmaceutical ingredient and to perform its quality control, in vitro activity conservation tests and human trials (safety evaluation). Both selected formulations reach the technological quality expected for 120 days, shows adequate occlusive characteristics and  proper adhesion to human skin. From the in vitro release assays were found that LAPS shows adequate release from matrix and maintain its antimicrobial and anti-biofilm activity. First human trials were developed and neither edema nor erythema on healthy skin voluntaries was found. We conclude that C80 and C100 are adequate for their use in future clinical trials to demonstrate a comprehensive therapeutic effectiveness in ischemic chronic wounds.","palabras_clave":"BACTERIA BY PRODUCTS|PHARMACEUTICAL BIOTECHNOLOGY|PSEUDOMONAS AERUGINOSA|PHARMACEUTICAL TECHNOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18580,"idioma_id":4,"titulo":"BLISS: Improved Symbolic Execution by Bounded Lazy Initialization with SAT Support","resumen":"Lazy Initialization (LI) allows symbolic execution to effectively deal with heap-allocated data structures, thanks to a significant reduction in spurious and redundant symbolic structures. Bounded lazy initialization (BLI) improves on LI by taking advantage of precomputed relational bounds on the interpretation of class fields in order to reduce the number of spurious structures even further. In this paper we present bounded lazy initialization with SAT support (BLISS), a novel technique that refines the search for valid structures during the symbolic execution process. BLISS builds upon BLI, extending it with field bound refinement and satisfiability checks. Field bounds are refined while a symbolic structure is concretized, avoiding cases that, due to the concrete part of the heap and the field bounds, can be deemed redundant. Satisfiability checks on refined symbolic heaps allow us to prune these heaps as soon as they are identified as infeasible, i.e., as soon as it can be confirmed that they cannot be extended to any valid concrete heap. Compared to LI and BLI, BLISS reduces the time required by LI by up to four orders of magnitude for the most complex data structures. Moreover, the number of partially symbolic structures obtained by exploring program paths is reduced by BLISS by over 50 percent, with reductions of over 90 percent in some cases (compared to LI). BLISS uses less memory than LI and BLI, which enables the exploration of states unreachable by previous techniques.","palabras_clave":"Symbolic execution|lazy initialization|tight field bounds|Symbolic PathFinder"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18581,"idioma_id":4,"titulo":"Parasitological Survey of Schoolchildren from a High-Altitude Community from Tucumán Province, Argentina. Remarkable Low Detection of Soil-Transmitted Helminths in Comparison with Coastal Communities.","resumen":"The prevalence of intestinal parasitic infections among schoolchildren in Colalao del Valle, a high-altitude community in Tucumán province, Argentina, was investigated. The data revealed a high prevalence of parasitism (79.7%) with no significant differences in distribution by sex or age. Protozoa infections were the most common with Blastocystis hominis being the most prevalent (62.5%), followed by Giardia lamblia (29.7%), Endolimax nana (15.6%), Entamoeba coli (12.5%) and Iodamoeba bustchili (3.1%). Interestingly, there was an absence of soil-transmitted helminths among the studied population which could be related to climate (variable temperatures, moderate rainfall) and soil type (clay).","palabras_clave":"high-altitude community|parasitological survey|Tucuman|Giardia lamblia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18582,"idioma_id":4,"titulo":"Holographic thermalization of charged operators","resumen":"We study a light-like charged collapsing shell in AdS-Reissner-Nordstrom  spacetime, investigating whether the corresponding Vaidya metric is supported  by matter that satisfies the null energy condition. We find that, if the  absolute value of the charge decreases during the collapse, energy conditions  are fulfilled everywhere in spacetime. On the other hand, if the absolute value  of the charge increases, the metric does not satisfy energy conditions in the  IR region. Therefore, from the gauge\/gravity perspective, this last case is  only useful to study the thermalization of the UV degrees of freedom. For all  these geometries, we probe the thermalization process with two point  correlators of charged operators, finding that the thermalization time grows  with the charge of the operator, as well as with the dimension of space.","palabras_clave":"HOLOGRAPHY|ADS\/CFT|THERMALIZATION|FIELD THEORY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18583,"idioma_id":4,"titulo":"Runaway stars as cosmic ray injectors inside molecular clouds","resumen":"Giant molecular clouds (GMCs) are a new population of gamma-ray sources, being the target of cosmic rays (CRs) -- locally accelerated or not --. These clouds host very young stellar clusters where massive star formation takes place. Eventually, some of the stars are ejected from the clusters, becoming runaway stars. These stars move supersonically through the cloud and develop bowshocks where particles can be accelerated up to relativistic energies. As a result, the bowshocks present non-thermal emission, and inject relativistic protons in the cloud. These protons diffuse in the GMC interacting with the matter. We present a model for the non-thermal radiation generated by protons and secondary pairs accelerated in the bowshocks of massive runaways stars within young GMCs. We solve the transport equation for primary protons and secondary pairs as the stars move through the cloud. We present non-thermal emissivity maps in radio and in gamma rays as a function of time. We obtain X-ray luminosities of the order &#8764; 1032 erg~s&#8722;1 and gamma-ray luminosities &#8764; 1034 erg~s&#8722;1. We conclude that, under some assumptions, relativistic protons from massive runaway stars interacting with matter in GMCs give rise to extended non-thermal sources.","palabras_clave":"radiation mechanisms: non-thermal |ISM: clouds| gamma-rays: ISM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18584,"idioma_id":4,"titulo":"Quantifying Insufficient Coping Behavior under Chronic Stress               A cross-cultural study of 1,303 students from Italy, Spain, and Argentina","resumen":"The question of how to quantify insufficient coping behavior under chronic stress is of major clinical relevance. In fact, chronic stress increasingly dominates modern work conditions and can affect nearly every system of the human body, as suggested by physical, cognitive, affective and behavioral symptoms. Sampling and Methods: Since freshmen students experience constantly high levels of stress due to tight schedules and frequent examinations, we have carried out a 3-center study of 1,303 students from Italy, Spain, and Argentina in order to develop socio-culturally independent means for quantifying coping behavior. The data analysis relied on 2 self-report questionnaires: the Coping Strategies Inventory ?COPE? for the assessment of coping behavior and the Zurich Health Questionnaire ?ZHQ? which assesses ?consumption behavior? and ?general health? dimensions. A Neural Network approach was used to determine the structural properties inherent in the COPE instrument. Results: Our analyses revealed 2 highly stable, socio-culturally independent scales that reflected basic coping behavior in terms of the personality traits ?activity-passivity? and ?defeatism-resilience?. This replicated previous results on the basis of Swiss and US-American data. The percentage of students exhibiting insufficient coping behavior was with 11.5-18.0% very similar across study sites. Conclusions: Given their stability and validity, the newly developed scales enable the quantification of basic coping behavior in a cost-efficient and reliable way, thus clearing the way for the ?early? detection of subjects with insufficient coping skills under chronic stress who may be at risk of physical or mental health problems.","palabras_clave":"Chronic Stress|students|insufficient coping skills"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18585,"idioma_id":4,"titulo":"Food composition data in Argentina: A systematic review of the literature","resumen":"Food composition data are essential for the assessment of nutrient intake and the development of foodpolicies. The aim of this study was to conduct a systematic review of available published data notpreviously included in the national food composition table in Argentina (ARGENFOODS), in order tosupplement the existing information. An electronic literature search was conducted of literaturepublished from January 1997 to December 2012. An annotated search for non-indexed ?gray literature?was also completed. Quality of data was assessed in terms of sampling and analytical criteria. A total of2474 potentially eligible references were identified, out of which 138 articles and reports met inclusioncriteria. These studies provided information about energy value, macronutrients, micronutrients, and\/orother components, such as phytochemicals, for 82 individual food items and multi-ingredient foods.Cereals, legumes and their derivatives, milk and dairy products, meat, fish and fish derivatives were themost frequently reported food groups. Non-representative sampling and poor description of theanalytical quality control used were the most frequent issues found in evaluation of data quality. Theseresults will contribute to the continuous and systematic updating of food composition databases, whichare of paramount importance for public health. Collaboration among data generators, compilers, andusers is essential.","palabras_clave":"SYSTEMATIC REVIEW|FOOD DATABASE|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18586,"idioma_id":5,"titulo":"MODELADO DE CALIDAD DE AGUA EN RIOS DE MONTAÑA CON IMPACTO ANTROPICO. CASO DE ESTUDIO: SIERRA CHICA DE CORDOBA, ARGENTINA","resumen":"Los modelos de calidad de agua constituyen una valiosa herramienta para analizar el estado ecológico de los sistemas hídricos y predecir la respuesta de estos sistemas frente a diferentes escenarios ambientales. Se presenta aquí un ejemplo de la aplicación del programa de modelado de calidad de agua QUAL2Kw en cuencas hídricas de montaña con impacto antrópico en la provincia de Córdoba, Argentina. Las cuencas de los ríos Ceballos y Salsipuedes drenan la ladera oriental de la Sierra Chica de Córdoba (31º 05´y 31°19´S y 64º 15´ y 64º 25´ O) y constituyen la principal fuente de abastecimiento de agua para consumo humano y recreación para las ciudades de la zona. Las aguas son bicarbonatadas cálcicas con una tendencia hacia términos sulfatados cálcico\/sódicos aguas abajo. La fuente natural de solutos en estas aguas son la meteorización química de silicatos y la disolución de carbonatos. En esta región el desarrollo urbano se ha incrementado notablemente durante los últimos años impactando directamente en la calidad de los recursos hídricos. Elevadas concentraciones de sulfatos, cloruros, sodio, nitratos, fósforo y bacterias coliformes totales y fecales fueron determinadas en las zonas más urbanizadas de la región, evidenciando la clara influencia antrópica sobre el medio natural. El empleo del programa de modelado de calidad de agua QUAL2Kw permitió evaluar cuali y cuantitativamente el comportamiento de las variables hidroquímicas mencionadas atribuidas principalmente a descargas difusas de origen antrópico, poniendo en evidencia la potencialidad del programa para la gestión integrada del rio en ambientes de montaña.","palabras_clave":"HIDROQUÍMICA|QUAL2Kw|USO DEL AGUA|RÍOS DE MONTAÑA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18587,"idioma_id":4,"titulo":"BIOADHESIVE HYDROGELS FOR COSMETIC APPLICATIONS.","resumen":"The use of bioahesive hydrogels for skin care presents important advantages such as long residence times on the application site and reduced product administration frequency. The aim of the present work was to develop bioadhesive hydrogels for skin application, using caffeine as a model active ingredient. Eight hydrogels were formulated using binary combinations of a primary polymer (carbomer homopolymer type C or kappa carrageenan potassium salt) and a secondary polymer (carbomer copolymer type B, xanthan gum or guar gum).Hydrogels were characterized by means of physico-chemical (dynamic rheological measurements, spreadability and adhesion measurements) and sensory methods (Napping® in combination with a check-all-that-apply -CATA- question). Caffeine hydrogels were formulated using two of the most promising formulations regarding adhesion properties and sensory characteristics. In vitro active ingredient release studies were carried out. Both hydrogels presented similar release profiles which were well described by the Higuchi model. Caffeine release was exclusively controlled by a diffusive process. In summary, bioadhesive hydrogel formulations presenting appropriate physico-chemical and sensory characteristics were obtained.","palabras_clave":"BIOADHESIVE POLYMERS|DELIVERY|RHEOLOGY|SKIN BARRIER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18588,"idioma_id":4,"titulo":"Study of Serotypes, Susceptibility to Macrolide and Virulence and Resistance Molecular Profiles in Invasive Strains of Streptococcus agalactiae in Two Argentine Provinces","resumen":"A study of invasive strains of Streptococcus agalactiae (GBS) from Cordoba and Misiones, Argentina;was conducted to determine serotypes, the susceptibility to macrolides and molecular profiles ofvirulence and resistance. We studied 17 strains, recovered from cerebrospinal fluid, blood andcellulite and, a strain of trophoblastic remnants from Misiones. The serotypes were determined byagglutination with sera and phenotypes of resistance to macrolide-lincosamide-streptogramin B(MLSB), were determined with the double-disk test (D-test). The confirmation was performed byE-test by ERI and CLI respectively that determined the minimum inhibitory concentration (MIC).Results were interpreted as recommended by the Clinical and Laboratory Standards Institute (CLSI)2013. Resistance genes: ermB, ermTR and mefA and the virulence genes: bac, bca, rib, lmb, hylB,scpB, fbsA, fbsB and cylB were investigated by conventional PCR. Serotype III (50%) and Ia (50%)were detected in Cordoba. One strain showed cMLSB phenotype, confirmed by MIC. The samestrains showed a resistance gene ermB. All studied virulence genes were detected in 100% ofthese strains. In Misiones, serotypes were III (72.7%), Ia (18.2%) and Ib (9.1%). All strains weresusceptible to CLI and ERI by D-test, confirmed by MIC. None of the strains showed resistancegenes. Virulence genes bca, rib, hylB, lmb, fbsA, fbsB and cylB were detected in 100% of the strains,bac in 81.8% and scpB in 90.9%. Our results are in accordance with international data, associatinghigher frequency of serotype III of invasive neonatal disease followed by Ia. The presence of serotype Ib could indicate a regional difference for Misiones. We highlight the macrolides susceptibility in strains of Misiones and consistency in the results for D-test, MIC and PCR for the single strainresistant phenotype cMLSB from Cordoba. The virulence genes studied were presented with highfrequency as expected for invasive strains.","palabras_clave":"STREPTOCOCCUS AGALACTIAE|PERINATAL INFECTION|MACROLIDES|RESISTENCE GENES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18589,"idioma_id":4,"titulo":"BIOTIC ASSEMBLAGES FROM LOWER CRETACEOUS LACUSTRINE SYSTEMS, SAN LUIS BASIN, CENTRAL-WESTERN ARGENTINA","resumen":"Significant paleobiological data came out from the San Luis Basin (Early Cretaceous, Aptian-Albian from Central Argentina) during the last decades. Two units in this basin include lake paleoenvironments and important fossil content in an excellent mode of preservation that could be considered as Konservat Lagerstatten deposits. The association of fossil leaves and pollen grains from La Cantera Formation is one of the most ancient and complete record of basal angiosperms in South America. The bryophyte association of the same unit constitutes one the most complete record of its type in Argentina. Insects from five different orders were identified in this association, and three endemic species of aquatic insects were described from La Cantera Formation belonging to the Families Notonectidae and Corixidae, including the oldest member of the Anisopinae subfamily.  The Pterodaustro guinazui association from Lagarcito Formation is one of the scarce fossil associations recorded worldwide from which it is possible to make studies on the life history parameters of pterosaurs like growth patterns and ontogeny. The Pleuropholid fishes from Lagarcito Formation are the only record of this rare group in Argentina and the second from South America. Several new species of Ostracods and Conchostracea are also recorded in these same levels. Despite the amount of paleontological information now available from this area, much work remains to be done on these fossil associations, the correlation between them and the interpretation of its depositional environments.","palabras_clave":"LA CANTERA|LACUSTRINE|SAN LUIS|CRETACEOUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18590,"idioma_id":4,"titulo":"Effect of Institutional Evaluation Policies on Private Universities in the Cuyo Region","resumen":"Latin American universities are currently dominated by evaluation policies implemented at the beginning of the 21st century. Both self-evaluation practices and external evaluation processes have created new ways of looking at the institution that is the university and have brought about tension with previously rooted aspects of the system. Private universities in the Cuyo region of Argentina have also developed institutional evaluation processes out of which new perspectives on institutional configurations have emerged. Their identitary grades, particular management styles and center west location in Argentina means they have particular ways of functioning that are occasionally identified as weaknesses in evaluative processes. The complexity of social, political, economic-administrative and even geographical contexts have great influence on the implementation of public policy. Such is also the case of that which occurs in academic contexts. University evaluation policies seem to be designed following a logic that is spurious for the organizational structure of private universities in the region. The present work is part of a doctoral thesis whose objective is to understand the reach of the Argentine state's influence through the adoption of models of external evaluation inside private universities in the Cuyo region, based on their relationship with the State and their organizational singularity. We specifically seek to systematize the institutional evaluation experiences of private universities in the Cuyo region, describe the way in which evaluative practices are developed at our reference universities and understand the changes that have come about from external evaluation at these institutions.","palabras_clave":"university evaluation |private sector"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18591,"idioma_id":4,"titulo":"First study of scpB gene of Streptococcus agalactiae in Misiones, Argentina","resumen":"Streptococcus agalactiae (GBS) is the leading cause of neonatal infections. GBS presents different surface proteins of antigenic characteristics. These proteins are encoded by several genesassociated with virulence and host interaction acting on bacteria involved in invasiveness. The study of these surface protein antigens is important for the understanding of the pathogenesis and epidemiology of the infection. Several of these antigens have been proposed as components of multivalent conjugate vaccines. This study focuses on the presence of scpB gene encoding theC5a peptidase in GBS. Recent studies indicate that C5a peptidase vaccine formulations cause a long-term immune response and prevent GBS infection. Methodology: A total of 200 Streptococcus agalactiae isolates were collected from vaginal or rectal swabs of pregnant women with 35 ? 37 weeks gestational age. Conventional biochemical tests and commercial kits for latex particle agglutination (Phadebact Strep B Test-ETC-Bactus International AB Sweden) were used to identify those isolates. GBS strains were preserved in 20% skim milk at -80°C and were recovered to search the gene scpB. The scpB gene was investigatedby conventional PCR. PCR products were visualized on 2% agarose gel gel stained with GelRed® (Biotium, Inc.; US) and visualized of bands in UV trans illuminator (MUV Model 21-312-220), using MP (D0017 marker DNA fragments made up of 10 double-stranded DNA molecular size of 100 to1000 pb-INBIO, Argentina).Results: The presence of the scpB gene was detected in 100% of Streptococcus agalactiae strains studied. Conclusion: Our findings highlight the importance of including C5a peptidase in the design of a regional vaccine. The high specificity of the scpB gene in GBS, and the lack of homologous sequences in other bacterial genera and species, makes it a molecular marker that can be used in the diagnosis of colonization or infection by this microorganism.","palabras_clave":"STREPTOCOCCUS AGALACTIAE|SCPB GENE|C5A PEPTIDASE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18592,"idioma_id":5,"titulo":"Uso de la entropía condicional como método para la reducción de dimensionalidad. Una aplicación en gestión de la innovación","resumen":"En una gran cantidad de contextos de investigación se presentan situaciones de alta dimensionalidad dada por la gran cantidad de observaciones, de variables, o por mayor cantidad de variables que de observaciones. La clasificación supervisada suele ser una técnica estadística muy utilizada para detectar variables que sean relevantes en la distinción entre grupos. No obstante, la alta dimensionalidad dada por una mayor cantidad de variables que de observaciones, hace que las técnicas convencionales sean inestables y poco confiables. Los métodos filtro resultan una buena estrategia para realizar un ordenamiento de las variables dada su importancia en la distinción entre grupos y reducir dimensionalidad. En este trabajo, se aplica un filtro que trabaja con la entropía condicional como medida de evaluación, en datos referidos al área de gestión de la innovación caracterizados por la presencia de variables cualitativas ordinales. Una vez ordenadas las variables, el investigador especialista en la temática decidirá las acciones a tomar. Por un lado, puede seleccionar las variables más relevantes para analizar su comportamiento con mayor detalle. Por otro, puede descartar las menos relevantes para, de esta manera, reducir la dimensionalidad y poder aplicar técnicas convencionales a las variables remanentes.","palabras_clave":"ENTROPIA|ALTA DIMENSIONALIDAD|FILTROS|SOFTWARE Y SERVICIOS INFORMÁTICOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18593,"idioma_id":4,"titulo":"Hepatocellular carcinoma and multidrug resistance: past, present and new challenges for therapy improvement","resumen":"Hepatocellular carcinoma (HCC) is the most common malignancy of the liver and the third cause of cancer death worldwide. Chronic hepatitis due to HBV and HCV infection are two major risk factors for HCC worldwide. Advances in early detection and treatment have improved life expectancy of patients with HCC. However, this disorder remains as a disease with poor prognosis. In fact, epidemiological studies have shown that the median survival of patients is 8 months and approximately 20% of them survive one year, while only 5% remain alive after three years. Additionally, HCC is particularly difficult to treat because of its high recurrence rate, and its resistance to conventional chemotherapy due to, among other mechanisms, the over-expression of several members of the ATP-Binding Cassette (ABC) protein family involved in drugs transport. Fortunately, there is evidence that these patients may benefit from alternative molecular-targeted therapies. This manuscript reviews the current knowledges on the etiology, molecular mechanisms involved in HCC development and the current therapy strategies for the management of this malignancy. The challenges in the development of drug delivery systems for the targeting of antitumoral drugs to the liver parenchyma are also discussed. Finally, perspectives in the design of a more efficient pharmacotherapy to overcome multidrug resistance are reviewed.","palabras_clave":"HEPATOCELLULAR CARCINOMA|THERAPY|MULTIDRUG RESISTANCE|DRUG DELIVERY SYSTEMS|LIVER TARGETING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18594,"idioma_id":4,"titulo":"Polyphenols as possible bioprotectors against cytotoxicity and DNA damage induced by ochratoxin A","resumen":"tThe present study aimed to investigate the protective effects of luteolin (L), chlorogenic acid(ChlA) and caffeic acid (CafA) against cyto-genotoxic effects caused by OTA. Vero cells andrat lymphocytes were used and viability was measured by neutral red uptake, MTT andtrypan blue dye exclusion method. L (50 and 100 g\/mL), ChlA (100 and 200 g\/mL) and CafA(10?50 g\/mL) reduced the damage induced by OTA (10 g\/mL) on both cells type shown agood protective effect. The comet and micronucleus tests in Balb\/c mice were performed.ChlA (10 mg\/kg bw) reduced OTA (0.85 mg\/kg bw)-induced DNA damage on blood and bonemarrow cells, CafA (10 mg\/kg bw) showed protective effect only in blood cells and luteolin(2.5 mg\/kg bw) failed to protect DNA integrity on cells. In conclusion, polyphenols testedreduced the toxicity caused by OTA on different target cells with good protective effect,being ChlA the compound that showed the best effects.","palabras_clave":"Luteolin, Chlorogenic acid|Caffeic acid|Ochratoxin A|CytotoxicityDNA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18595,"idioma_id":5,"titulo":"Impacto de la ardilla de vientre rojo sobre la comunidad de aves en la Región Pampeana, Argentina","resumen":"Impact of red-bellied squirrels on the bird community of the Pampas Region, Argentina: Biological invasions are a major threat to native species. The red-bellied tree squirrel Callosciurus erythraeus was introduced in Luján, Argentina, in 1970, where it spread rapidly. Squirrels can affect birds through nest predation, interference and competition for food and nesting sites. We aimed to compare community composition, density and richness of birds in forested areas within and outside the range distribution (680 km2 in 2004) of the mainpopulation of these squirrels in the country. We selected seven paired sites (each pair had similar vegetation structure and composition) and other 14 sites, half in each condition (with and without squirrels). In each of these 28 sites, we did 4?5 point counts in each site during spring-summer 2008-2009, recording all bird individuals that were seen\/heard &lt;10?20 m from the observer. Species richness was rarefied to the smallest number of point counts per site. Community composition differed among sites with and without squirrels, particularly for paired sites. We found no differences in bird density though species richness was higher for paired sites without squirrels. To assess if squirrels do consume bird eggs and if they have any egg-size preference, we conducted cafeteria experiments offering fruit and three eggs of different sizes to individual squirrels kept in a large cage (3x2x2 m) for &lt; 24 h. Few squirrels (2\/25) consumed the eggs. Our results suggest that squirrels could negatively affect some bird species but not through nest predation.","palabras_clave":"ARDILLAS INTRODUCIDAS|CALLOSCIURUS ERYTHRAEUS|DENSIDAD DE AVES|ESPECIES INVASORAS|RIQUEZA DE AVES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18596,"idioma_id":4,"titulo":"The University and Its Regional Economic Context, Productive Mining Sector Demands on Education","resumen":"This presentation describes some conclusions taken from research carried out by a network of universities from themacro Andean region of San Juan-Coquimbo regarding the relationship between these universities and the productive sector. The objective of these actions is to contribute to the universities? strategic planning and to the definition of institutional policies promoting regional development. In this particular case, we address the demands of the productive mining sector on academic institutions. A methodological qualitative approach is used. The techniques and instruments used include: document analysis, interviews and focus groups to gather the opinions of academic experts on the matter, both references from the productive sector and from the political sector of the macro region. Our work identifies educational needs\/vacancies related to the region?s mining activity and proposes lines of research oriented towards articulation between mining activity and other social actors and sectors of regional production. In this sense, our work describes the characteristics of the development of productive mining in the macro region, as well as the educational proposals related to the needs of the mining sector, to research activities, and to the development and transferring to the medium.","palabras_clave":"Educational Demands,|Productive Sector|Regional Economy|Andean Region?s Universities"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18597,"idioma_id":5,"titulo":"Malnutricion: impacto de los habitos, variables constitutivas y condiciones socioeconomicas en la población adulta urbana en Argentina","resumen":"Introducción: el término malnutrición se refiere a los desequilibrios en la ingesta de energía, proteínas y\/o nutrientes involucrados tanto en la desnutrición como en la obesidad. El objetivo del trabajo es identificar el efecto de las variables constitutivas del sujeto, sus hábitos y condiciones socioeconómicas sobre categorías nutricionales de la población adulta urbana de Argentina.Metodología: se estima un modelo logístico multinomial aplicado a los datos de la Encuesta Nacional de Factores de Riesgo de 2005 y 2009. Se presentan además indicadores de riesgo relativo asociados a cada cofactor.Resultados: la desnutrición se asocia con las variables constitutivas y socioeconómicas, mientras que en la obesidad intervienen además los hábitos. Discusión: la complejidad de los problemas nutricionales en Argentina, originada en la heterogeneidad en hábitos alimentarios y condiciones de vida, torna complejas las intervenciones necesarias para solucionarlos destacando el carácter multidimensional de la problemática (médica, social, económica).","palabras_clave":"desnutricion|obesidad y sobrepeso|estilos de vida"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18598,"idioma_id":5,"titulo":"Desarrollo  de un sistema de detección de contaminación viral aplicable al control de la inocuidad agroalimentaria","resumen":"La Comisión del Codex Alimentarius, pertenecientea la Organización Mundial de la Salud (OMS) yla Organización de las Naciones Unidas para laAlimentación y la Agricultura (FAO), ha propuestoguías para el control de la contaminación por virusentéricos en alimentos. Señalan como virus prioritariospara la salud pública a norovirus (NoV) y al virus dehepatitis A (HAV). El virus de hepatitis E (HEV) es otrovirus de creciente interés durante los últimos años, dadosu potencial riesgo zoonótico. Estos virus causantes degastroenteritis y hepatitis aguda con transmisión fecaloralpueden estar presentes aun cuando los estándaresbacterianos indicaran buena calidad microbiológica.Las técnicas empleadas en la detección de virus enalimentos se basan en la elusión y concentración delos virus desde matrices sólidas o líquidas seguidasde técnicas moleculares para la detección de ácidosnucleicos. Distintos países han implementadonormativas para controlar la presencia de virus enalimentos, pero en la Argentina no existe aún undesarrollo de la metodología apropiada para estosanálisis. El objetivo de este proyecto es implementartécnicas útiles para el control virológico de productosalimenticios y para la investigación de brotes deenfermedades transmitidas por alimentos (ETA) deorigen no bacteriano.Palabras clave: virus entéricos, enfermedad detransmisión alimentaria, detección viral.","palabras_clave":"Alimentos|Virus|Patogenos|Detección"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18599,"idioma_id":4,"titulo":"Search for pair-produced long-lived neutral particles decaying in the ATLAS hadronic calorimeter","resumen":"The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay ofa scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in20.3 fb&#1048576;1 of data collected in proton?proton collisions atps = 8 TeV. This search is sensitive to longlivedparticles that decay to Standard Model particles producing jets at the outer edge of the ATLASelectromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events isobserved. Limits are reported on the product of the scalar boson production cross section timesbranching ratio into long-lived neutral particles as a function of the proper lifetime of the particles.Limits are reported for boson masses from 100 GeV to 900 GeV, and a long-lived neutral particlemass from 10 GeV to 150 GeV.&nbsp;","palabras_clave":"atlas|neutral particles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18600,"idioma_id":4,"titulo":"Locally conformally Kähler structures on unimodular Lie groups","resumen":"We study left-invariant locally conformally Kähler structures on Lie groups, or equivalently, on Lie algebras. We give some properties of these structures in general, and then we consider the special cases when its complex structure is bi-invariant or abelian. In the former case, we showthat no such Lie algebra is unimodular, while in the latter, we prove that if the Lie algebra is unimodular, then it is isomorphic to the product of R and a Heisenberg Lie algebra.","palabras_clave":"Hermitian metric|Locally conformally Kähler metric|Abelian complex structure"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18601,"idioma_id":4,"titulo":"Search for Higgs and Z Boson Decays to J\/&#968;&#947; and &#933;(nS)&#947; with the ATLAS Detector","resumen":"A search for the decays of the Higgs and Z bosons to J\/&#968;&#947; and &#978;(nS)&#947; (n=1,2,3) is performed with pp collision data samples corresponding to integrated luminosities of up to 20.3&#8201;&#8201;fb-1 collected at s=8&#8201;&#8201;TeV with the ATLAS detector at the CERN Large Hadron Collider. No significant excess of events is observed above expected backgrounds and 95% C.L. upper limits are placed on the branching fractions. In the J\/&#968;&#947; final state the limits are 1.5×10-3 and 2.6×10-6 for the Higgs and Z boson decays, respectively, while in the &#978;(1S,2S,3S)&#947; final states the limits are (1.3,1.9,1.3)×10-3 and (3.4,6.5,5.4)×10-6, respectively.","palabras_clave":"ATLAS|HIGGS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18602,"idioma_id":4,"titulo":"The antimicrobial peptide microcin J25 stabilizes the gel phase of bacterial model membranes","resumen":"The bacterial membrane interaction of the antimicrobial peptide microcin J25 was studied with the probe-free techniques Langmuir monolayers and infrared spectroscopy. Membrane model systems composed by phosphatidylethanolamine:phosphatidylglycerol 7:3, which mimic the cytoplasmic membrane of Gram negative bacteria, were used in both monolayer and bilayer approaches. The peptide reduced the transition surface pressure of the expanded-to-condensed lipid monolayer states, as well as increased the gel-to-liquid crystalline transition temperature in bilayers, indicating a stabilization of membrane ordered state. In addition, a reduction of the surface pressure at which condensed domains appeared was observed upon mixed monolayers compression after microcin J25 adsorption. The results indicate a favorable interaction of microcin J25 with bacterial membrane model systems. Also, the effects on the ordered phases stabilization are discussed in terms of the biological effects observed in membranes of sensitive cells.","palabras_clave":"MICROCIN J25|MODEL MEMBRANE|ORDERED PHASE STABILIZATION|ANTIMICROBIAL PEPTIDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18603,"idioma_id":4,"titulo":"Development of biopolymer nanocomposite for silver nanoparticles and Ciprofloxacin controlled release","resumen":"tScreening of biopolymeric gel beads containing Silver NanoParticles (Ag-NPs) stabilized in Guar GumAlkyl Amine (GGAA) and Ciprofloxacin (Cip) was carried out in order to obtain a novel nanocompositewith controlled release profile of both antimicrobians. The selected matrix composed of Alginate\/HighMethoxyl Pectin (HMP)\/GGAA (4:4:1) was able to co-incorporate Ag-NPs and Cip with encapsulationefficiency higher than 70%. SEM images revealed good cohesivity and compatibility between the biopoly-mers and the cargos. Beads provided protection against Ag-NPs degradation at acidic pHs and HMP wouldplayed a key role providing hydrophobic regions. While Cip release profile showed a pH independent dif-fusional process, Ag-NPs release was restricted to matrix erodability. Calcium quelating agents and\/oralginate degrading enzymes could modulate the release profile. The bactericidal activity of beads wastested in liquid medium, showing cooperative effects between the antimicrobials against Pseudomonasaeruginosa, Escherichia coli, Bacillus cereus and Staphylococcus aureus. TEM images confirmed interactionof Ag-NPs with bacterial surfaces followed by membrane damage. Results suggested the nanocompositematrix as a promising system for oral treatment of intestinal infectious diseases caused by multidrugresistant and unknown microorganisms, since both Cip and Ag-NPs would be able to reach intestine inthe active form.","palabras_clave":"guar gum alkyl amine|silver nanoparticles|ciprofloxacin|alginate|pectin|antimicrobial matrices"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18604,"idioma_id":5,"titulo":"PREVALENCIA DEL CONTROL INSTRUCCIONAL SOBRE LAS CONSECUENCIAS DIFERENCIALES DE RESPUESTA EN LA EMERGENCIA DE CONDUCTAS DERIVADAS","resumen":"Varios estudios han abordado cómo las instrucciones compiten con contingencias de reforzamiento para controlar conductas complejas, pero no se ha estudiado cabalmente cómo el control instruccional afecta a las conductas derivadas, no explícitamente entrenadas. Este estudio intentó determinar si las instrucciones ejercen mayor control que las consecuencias diferenciales de respuesta sobre conductas derivadas, en sintonía con la literatura sobre 'insensibilidad a las contingencias'. 46 participantes realizaron una tarea de emparejamiento con la muestra, analizándose su preferencia para derivar relaciones de equivalencia entre estímulos que fueron vinculados de dos maneras contradictorias, una por instrucciones y otra por consecuencias diferenciales. Se observó una mayor eficacia del método de entrenamiento por instrucciones para aprender relaciones condicionales entre estímulos. Por otro lado, se constató una significativa prevalencia para formar relaciones de equivalencia de aquello aprendido previamente por instrucciones, aunque este aspecto podría estar vinculado a la mayor eficacia en el aprendizaje de los contenidos previos.","palabras_clave":"INSTRUCCIONES | CONTINGENCIAS|CONDUCTASDERIVADAS|RELACIONESDEEQUIVALENCIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18605,"idioma_id":4,"titulo":"Evaluation of Silica as an Adsorbent for Carbendazim  from Aqueous Solutions","resumen":"Adsorption of carbendazim onto silica has been studied. The influence of contact time, pH, ionic strength and temperature has been determined. The adsorption isotherms can be described by the Langmuir model. Adsorption appears to be  more effective as pH increases and it is not significantly affected by ionic strength of the sample (except at high I values).  Spectroscopic and thermogravimetric results suggest that carbendazim is adsorbed in its protonated form. Results indicate that after the treatment with silica, roughly 90% carbendazim can be removed from the aqueous solutions, making this  adsorbent as a potential candidate for water treatment processes.","palabras_clave":"adsorption| carbendazim| pesticide| silica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18606,"idioma_id":4,"titulo":"Failure Profiles for Maintenance in Industrial Facilities","resumen":"[Journal Indexado por Scimago, Directory of Open Access Journals (DOAJ), Cite Factor, Scopus, entre otros] This work presents a new classification for thefailure profiles in maintenance. This paper reviews originalworks of different authors in the area of maintenance anddiscusses new evidence or prior evidence to conclude that a newclassification is necessary. This work progresses to use this newinformation in the management of industrial installationsmaintenance and include a guide to an effectiveness use of thenew profiles.","palabras_clave":"FAILURES|MAINTENANCE|PROFILES|RELIABILITY-CENTERED-MAINTENANCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18607,"idioma_id":5,"titulo":"La figura del psicólogo en el cine y las series televisivas: cuestiones ético-clínicas","resumen":"La figura del psicoterapeuta en los medios ha tenido un incremento notorio durante los últimos años. Series como In Treatment y su versión local En Terapia; Historias de diván, y más recientemente PS! han puesto el acento no sólo en las cuestiones técnicas de la labor sino que han desplegado las cuestiones éticas de nuestra práctica. ¿Puede un terapeuta involucrarse amorosamente con una paciente que acaba de interrumpir su tratamiento? ¿Debe guardar el terapeuta confidencialidad frente a crímenes de guerra? ¿Cómo debe manejar un terapeuta sus conflictos personales cuando éstos interfieren con el trabajo profesional? Estas y otras cuestiones aparecen desplegadas para el gran público, generando una representación social de la figura del profesional y sus conductas deseables. Este trabajo, fruto de una investigación en curso dentro del Programa de Ciencia y Técnica de la UBA, indaga estas cuestiones desde dos perspectivas: (1) qué tipo de valores y nociones de derechos se imparten a la comunidad a partir de estos fenómenos de masa; (2) cuáles son los recaudos que se deben tomar cuando se llevan a la pantalla situaciones inspiradas en casos reales de pacientes. Ambas dimensiones hacen a una responsabilidad del psicólogo frente a un mundo cada vez más comunicado pero a la vez más intenso e inmediato.","palabras_clave":"CONFIDENCIALIDAD|CONFLICTO DE INTERESES|PSICOLOGO|CINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18608,"idioma_id":4,"titulo":"Assessment of Biofuel Accident Risk. A preliminary study","resumen":"[Journal Indexado por Scimago, Directory of Open Access Journals (DOAJ), Cite Factor, Scopus, entre otros] This work presents a study of accidents withfatalities in biofuel industries. The objective is to presentpreliminary accident risks associated with biodiesel andethanol plants. The analysis is based on data occurring from2003 to November 2013. Data statistical analysis shows that thefrequency of accidents in biofuel plants has an increasingtendency, being fires and explosions the main type of accidentsthat occurred.","palabras_clave":"ACCIDENTS|BIOFUEL|BIODIESEL|ETHANOL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18609,"idioma_id":4,"titulo":"Relationships between main accidental variables at ethanol fuel industry","resumen":"[Journal Indexado por Scimago, Directory of Open Access Journals (DOAJ), Cite Factor, Scopus, entre otros] Increasing global energy demands have generatedan exponential growth of world biofuel production, amongwhich ethanol can be found. This growth has been accompaniedby rising accidental rates. Given the difficulty of modelling thehuman error in this type of facilities, the objective of the presentwork is to determine if there is correlation between productionand the number of accidents. Additionally, a MultipleCorrespondence Analysis and an Association Analysis throughContingency Tables are going to be made in order to determineassociation between the different analyzed variables. Data foranalysis comprises accidents and incidents occurred at ethanolfuel facilities between 1998 and January, 2014.","palabras_clave":"ACCIDENTS|BIOFUEL|ETHANOL FACILITIES|HUMAN ERROR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18610,"idioma_id":4,"titulo":"Magnons and excitation continuum in XXZ triangular antiferromagnetic model:  Application to Ba3CoSb2O9","resumen":"We investigate the excitation spectrum of the triangular-lattice antiferromagnetic XXZ model using series expansion and mean field Schwinger boson approaches. The single-magnon spectrum computed with series expansion exhibits rotonic minima at the middle points of the edges of the Brillouin zone, for all values of the anisotropy parameter in the range $0 leq J\/J_z le1 1$. Based on the good agreement with series expansion for the single-magnon spectrum, we compute the full dynamical magnetic structure factor within the mean fieldSchwinger boson approach to investigate the relevance of the XXZ model for the description of the unusual spectrum found recently in Ba$_3$CoSb$_2$O$_9$. In particular, we obtain an extended continuum above the spin wave excitations, which is further enhanced and brought closer to those observed in Ba$_3$CoSb$_2$O$_9$ with the addition of a second neighbor exchange interaction approximately 15% of the nearest-neighbor value. Our results support the idea that excitation continuum with substantial spectral-weight are generically present in two-dimensional frustrated spin systems and fractionalization in terms of bosonic spinons presents an efficient way to describe them.","palabras_clave":"STRONG CORRELATION|MAGNETIC FRUSTRATION|HEISENBERG MODEL|MAGNONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18611,"idioma_id":4,"titulo":"Principal issues in human reliability analysis","resumen":"[Journal Indexado por Scimago, Directory of Open Access Journals (DOAJ), Cite Factor, Scopus, entre otros] The purpose of this article is to review thecriticisms made to human reliability models. As a result of thisreview the observations and critiques are grouped into threemain issues: (1) model?s theoretical basis (including taxonomyand concept?s specificity), (2) definition and use ofperformance shaping factors (PSF) and (3) HRAquantification. The cross-cutting aspects in the three issuessuggest the use of a human abilities taxonomy based oncognitive theories and a mathematical tool that allows thequantification of vague parameters.","palabras_clave":"HUMAN RELIABILITY MODELS|HUMAN FACTOR|HUMAN ERROR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18612,"idioma_id":5,"titulo":"Einstein y la evidencia experimental a favor de la hipótesis del cuanto de luz. Una respuesta a Michel Paty","resumen":"En su detallado comentario a nuestro artículo 'Einstein y el efecto Compton', Michel Paty ha formulado varias críticas y objeciones a nuestro tratamiento del desarrollo histórico del concepto de cuanto de luz en la obra de Einstein.2 El artículo de Paty no se limita a un mero comentario crítico, sino que aporta, además, diversos elementos de juicio acerca del pensamiento de Einstein sobre este tema, en particular, aquellos que proceden de los años 1924 y 1925, que nosotros no tuvimos en cuenta en nuestro trabajo. Agradecemos sinceramente estos aportes y, como señalaremos enseguida, creemos que efectivamente proporcionan valiosa información complementaria a la de nuestro artículo y que deberían ser tenidos en cuenta para una evaluación global de las ideas de Einstein sobre la teoría cuántica de la radiación, aunque ese no era el objetivo de nuestro trabajo.  En este artículo quisiéramos responder a algunas de las principales críticas de Paty, para luego mencionar otros elementos de juicio que consideramos relevantes para una apreciación ponderada del problema de la realidad de los cuantos de luz en el momento en que Einstein escribió el artículo sobre el efecto Compton (Einstein, 1924), cuya edición y traducción presentamos en nuestro trabajo, y en el curso del año siguiente, cuando se descubrieron nuevas evidencias experimentales.","palabras_clave":"Efecto Compton|Einstein|Cuanto de luz"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18613,"idioma_id":5,"titulo":"El efecto del priming  asociativo verbal mediante un paradigma de producción implícita en el  acceso al léxico","resumen":"Varios trabajos han investigado las particularidades del priming semántico y del priming asociativo verbal durante la producción de una palabra. No obstante, el rol de las relaciones asociativas en el proceso de producción (principalmente en la denominación de imágenes) ha sido menos estudiado; y por lo tanto, la caracterización de su efecto y su localización no son totalmente claros. El objetivo principal del presente trabajo experimental fue confirmar la presencia de un efecto de priming asociativo verbal utilizando una tarea de detección del fonema inicial del nombre del objeto-target. La realización de esta tarea exige la recuperación de la forma fonológica del nombre del objeto sin dar lugar a su articulación efectiva, como sí ocurre en la tarea de denominación de imágenes. Para ello, se llevaron a cabo dos experimentos. El experimento 1 mostró un efecto de facilitación asociativa verbal en la condición de asociados (en comparación a una condición control) sin la puesta en juego de los procesos articulatorios. El segundo experimento tuvo como objetivo confirmar la naturaleza no estratégica del efecto de facilitación asociativa que se encontró en el experimento 1. Los datos obtenidos permiten confirmar que el acceso a la forma fonológica del nombre de un objeto puede ser facilitado por la presentación previa de una palabra inductora o ?prime? asociativamente relacionada (caracterización del efecto). Y dadas las particularidades del paradigma utilizado, el efecto observado de facilitación ocurre a un nivel pre-articulatorio (a nivel de la forma fonológica) de procesamiento (localización del efecto).","palabras_clave":"PRIMING ASOCIATIVO VERBAL|TÉCNICA DE DETECCIÓN DE FONEMAS|NIVEL DE LA FORMA FONOLÓGICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18614,"idioma_id":5,"titulo":"La inserción de los Graduados 2011 y 2012 de la Universidad Nacional de La Matanza en el mercado laboral","resumen":"El Proyecto propone analizar la inserción de los graduados 2011 y 2012 de la Universidad Nacional de La Matanza en el mercado laboral actual. A partir de este estudio se intentará demostrar si los graduados 2011 y 2012 de la Universidad Nacional de La Matanza se encuentran desempeñando funciones, en el ámbito profesional, según su titulación obtenida en la Universidad.   Para llevar adelante este Proyecto se realizará una investigación de campo, entre la herramientas que se utilizarán estará el cuestionario, la entrevista, el focus group y datos estadísticos entre otros. De este modo se confrontarán los resultados obtenidos con el marco teórico sobre inserción de graduados en el mercado laboral. Por otra parte, se intentará demostrar sí la Universidad Nacional de La Matanza forma graduados con habilidades profesionales para el campo laboral actual. Además, se pondrá en evidencia sí los contenidos adquiridos en el trayecto formativo les han permitido a estos insertarse laboralmente según su titulación. Y por último, será necesario detectar cuáles son las mayores dificultades en la inserción en el mercado laboral por parte de los Graduados de la Universidad Nacional de La Matanza.   Finalmente, los resultados de la investigación tienen como objeto ser el inicio de un Proyecto más amplio acerca del seguimiento de los graduados de la Universidad Nacional de La Matanza. A partir de esto se desea producir conocimientos, estadísticas y datos que sirvan para conocer la inserción y el desarrollo de los profesionales de dicha Casa de Altos Estudios.","palabras_clave":"GRADUADOS UNLAM|INSERCIÓN LABORAL|MERCADO LABORAL ACTUAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18615,"idioma_id":4,"titulo":"A cytogenetic, molecular genetic and morphological study of Patagonian chinchilla mice Euneomys (Rodentia, Cricetidae) in the Southern Central Andes","resumen":"Euneomys is a genus of sigmodontine rodent   endemic to South America, distributed along the Andes of Argentina and   Chile and in adjoining Patagonian steppe. Here, we studied specimens of Euneomys   from different localities in the Central Andes, Mendoza Province,   Argentina. Karyotypic analyses confirm the presence of a new karyomorph   of Euneomys chinchilloides, the form 2n&#8201;=&#8201;34, FN&#8201;=&#8201;62?64. This new karyomorph differs from the form E. chinchilloides with 2n&#8201;=&#8201;36, FN&#8201;=&#8201;64?66. The chromosome complement with 2n&#8201;=&#8201;36 has an extra pair of small acro-telocentric chromosomes that is not present in individuals with 2n&#8201;  =&#8201;34. We also found small differences in molecular analyses with the   mitochondrial COI gene. We recovered two monophyletic clades, one with   specimens with 2n&#8201;=&#8201;34 and the other one with specimens with 2n&#8201;  =&#8201;36, which are separated by a range of 0.7 to 1.2&nbsp;% sequence   divergence. Individuals from the two clades also show some morphological   differences. Significant difference in the length of ear was found   between the specimens with 2n&#8201;=&#8201;34 and 36,   and qualitative differences in the shape of the incisive foramen, the   palate, and the palatine fossa were observed. The modification on   fundamental and diploid number that we found between the two karyomorphs   of E. chinchilloides can be the result of   tandem chromosome fusion; such rearrangements are strongly negatively   heterotic and lead to reproductive isolation between differentiated   populations. Thus, the integrated cytogenetic, molecular, and   morphologic analyses show concordant differentiation between the two   karyomorph types of the uncommon E. chinchilloides   from the Southern Central Andes of Argentina. The evidence presented   here might reflect a recent and\/or incipient allopatric speciation   event. Further investigations are needed to elucidate the taxonomic and   distributional status of species of Euneomys.","palabras_clave":"ARGENTINA|BIOGEOGRAPHY|EUNEOMYS CHINCHILLOIDES|COI |CYTOGENETICS|SYSTEMATICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18616,"idioma_id":4,"titulo":"Photosynthetic light requirements and vertical distribution of macroalgae in newly ice-free areas in Potter Cove, South Shetland Islands, Antarctica","resumen":"In Potter Cove, Antarctica, newly ice-free areasappeared due to glacial retreat. Simultaneously, the inflowof sediment increased, reducing underwater photosyntheticallyactive radiation (PAR, 400?700 nm). The aim ofthis study was to determine the photosynthetic characteristicsof two macroalgal species colonizing three newly icefreeareas, A1, A2 and A3, with increasing degree of glacialinfluence from A1 to A3. Turbidity, salinity and temperaturewere measured, and light attenuation coefficients(Kd) calculated and considered as a proxy for glacialsediment input. The lower depth distribution of the red algaPalmaria decipiens and the brown alga Himantothallusgrandifolius was 10 m in A3, 20 m in A2 and 30 m in A1.Both species were then collected, at 5 and 10 m at all areas.Photosynthetic parameters and the daily metabolic carbonbalance (CB) were determined. Kd was significantly higherin A3 compared with A1 and A2. The CB of P. decipienswas significantly higher in A1 followed by A2 and A3, andsignificantly higher at shallower than at greater depth. ForH. grandifolius CB was significantly lower in A3 and in A2at deeper depths compared with the rest of areas anddepths. The lower distribution limit of the algae waspositively correlated to the light penetration. An increase inthe sediment run-off due to global warming might lead toan elevation of the lower depth distribution limit but retreatingglaciers can open new space for macroalgalcolonization. These changes will probably affect macroalgalprimary productivity in Potter Cove with consequencesfor the coastal ecosystem.","palabras_clave":"Depth zonation     |Glacial retreat  |Global warming|Seaweeds | Sediment inflow"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18617,"idioma_id":4,"titulo":"Block modeling of crustal deformation in Tierra del Fuego from GNSS velocities","resumen":"The Tierra del Fuego (TDF) main island is divided by a major transform boundary between the South America and Scotia tectonic plates. Using a block model, we infer slip rates, locking depths and inclinations of active faults in TDF from inversion of site velocities derived from Global Navigation Satellite System observations. We use interseismic velocities from 48 sites, obtained from field measurements spanning 20 years. Euler vectors consistent with a simple seismic cycle are estimated for each block. In addition, we introduce far-field information into the modeling by applying constraints on Euler vectors of major tectonic plates. The difference between model and observed surface deformation near the Magallanes Fagnano Fault System (MFS) is reduced by considering finite dip in the forward model. For this tectonic boundary global plate circuits models predict relative movements between 7 and 9 mm\/yr, while our regional model indicates that a strike-slip rate of 5.9 ± 0.2 mm\/yr is accommodated across the MFS. Our results indicate faults dipping 66+6-4° southward, locked to a depth of 11+5-5 km, which are consistent with geological models for the MFS. However, normal slip also dominates the fault perpendicular motion throughout the eastern MFS, with a maximum rate along the Fagnano Lake.","palabras_clave":"INTERSEISMIC DEFORMATION|GNSS VELOCITIES|CONTINENTAL TRANSFORM BOUNDARY|TIERRA DEL FUEGO|MAGALLANES-FAGNANO FAULT SYSTEM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18618,"idioma_id":4,"titulo":"Power-based control with integral action for wind turbines connected to the grid","resumen":"In this paper, a power shaping control with integral action is employed to control active and reactive powers of wind turbines connected to the grid. As it is well known, power shaping allows finding a Lyapunov function which ensures stability. In contrast to other passivity-based control theories, the power shaping controller design allows to use easily measurable variables, such as voltages and currents which simplify the physical interpretation and, therefore, the controller synthesis. The strategy proposed is evaluated in the context of severe operating conditions, such as abrupt changes in the wind speed and voltage drops.","palabras_clave":"power shaping|passivity|wind generation|renewable distributed generation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18619,"idioma_id":5,"titulo":"Redes semánticas poblacionales: un instrumento metodológico para la investigación educativa","resumen":"Presentamos una propuesta metodológica cualitativa para indagar aprendizajes de una población de estudiantes. Utilizamos el concepto de red semántica para la representación gráfica de las respuestas individuales de los estudiantes frente a un problema determinado. Asimismo, el modelo de procesamiento de la información proporcionó la base teórico-práctica para la confección de los caminos cognitivos asociativos expresados por cada sujeto. Esta combinación teórico metodológica permitió elaborar redes semánticas poblacionales que representan la información acerca de los conocimientos declarativos de la población. Se propuso a estudiantes universitarios, de las asignaturas Biología y Química Biológica de distintas carreras, un problema de múltiples resoluciones acerca del metabolismo de los carbohidratos. Al ordenar las respuestas de todos los estudiantes en redes semánticas detectamos: (a) tendencias generales de errores arraigados que se repiten en cada asignatura, y (b) tendencias específicas de estrategias de respuestas o de errores que sólo aparecen en alguna de las poblaciones.","palabras_clave":"ENSEÑANZA SUPERIOR|METODOLOGÍA INVESTIGATIVA|REDES SEMÁNTICAS|METABOLISMO DE HIDRATOS DE CARBONO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18620,"idioma_id":4,"titulo":"The ipdC, hisC1 and hisC2 genes involved in indole-3-acetic production used as alternative phylogenetic markers in Azospirillum brasilense","resumen":"Plant growth-promoting bacteria of thegenus Azospirillum are present in the rhizosphere andas endophytes of many crops. In this research westudied 40 Azospirillum strains isolated from differentplants and geographic regions. They were first characterizedby 16S rDNA restriction analysis, and theirphylogenetic position was established by sequencingthe genes 16S rDNA, ipdC, hisC1, and hisC2. Thelatter three genes are involved in the indole-3-pyruvicacid (IPyA) biosynthesis pathway of indole-3-aceticacid (IAA). Furthermore, the suitability of the 16S-23S rDNA intergenic spacer sequence (IGS) for thedifferentiation of closely related Azospirillum taxaand development of PCR protocols allows forspecific detection of strains. The IGS-RFLP analysisenabled intraspecies differentiation, particularly ofAzospirillum brasilense and Azospirillum lipoferumstrains. Results demonstrated that the ipdC, hisC1, andhisC2 genes are highly conserved in all the assessed A.brasilense isolates, suggesting that these genes can beused as an alternative phylogenetic marker. In addition,IAA production determined by HPLC rangedfrom 0.17 to 98.2 lg mg-1 protein. Southern hybridizationwith the A. brasilense ipdC gene probe didnot show, a hybridization signal with A. lipoferum,Azospirillum amazonense, Azospirillum halopreferansand Azospirillum irakense genomic DNA. This suggeststhat these species produce IAA by other pathways.Because IAA is mainly synthesized via the IPyApathway in A. brasilense strains, a species that is usedworldwide in agriculture, the identification of ipdC,hisC1, and hisC2 genes by PCR may be suitable forselecting exploitable strains.","palabras_clave":"AZOSPIRILLUM|INDOLE-3-ACETIC ACID PRODUCTION|IPDC HISC1 HISC2|16S-23S RDNA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18621,"idioma_id":4,"titulo":"Clinical Documents Representation with Parsing Outcomes Ontology","resumen":"Objectives: To introduce a first approach of Parsing Outcomes Ontology (POO). POO provides an ontological model to the grammatical constituents of natural languages. This model is conceived as a base for analysis of clinical documents.  Method: POO is an ontology developed from grammatical constituents represented by different parsers, and the ontological individuals, are obtained by parsing clinical documents. Then, the individuals are interpreted under another ontology, which models a specific semantic context. Results: We have represented part of a clinical document under POO. Then, we interpreted the POO individuals under an ontology of a particular theory of clinical thinking. Conclusions: POO allow us to represent ontologically the grammatical constituents of clinical documents. That representation was a base for the interpretation of a document under a specific point of view modeled with another ontology. This two level representation is intended as a generalizable method for different contextual  interpretations of clinical documents.","palabras_clave":"ONTOLOGY|CLINICAL DOCUMENTS|NATURAL LANGUAGE PARSING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18622,"idioma_id":4,"titulo":"Non-linear dynamics of litter decomposition under different grazing  management regimes","resumen":"Aims: To understand and model the dynamics of litter decomposition in a climatically seasonal region subject to different modalities of landpasture management.  Methods: Decomposition was quantified through the litterbag technique. Sampling was performed at monthly intervals on an annual basis with replications for 2008, 2009 and 2010. Treatments were native vegetation (NV) and grazed (G), grazed and N-fertilized (GF), hayed (H), hayed and N-fertilized (HF) plots. For each combination of treatment and year, a sigmoid model was fitted. Parameters included remnant litter, steepness and inflection of decomposition curve.  Results: The sigmoid model adjusted excellently well the data. In considering the overall effect on litter decomposition, treatments differ among them as follows symbolically: ((GF>G) > (HF>H)) >> NV. Results are consistent across the yearly replications.  Conclusion: Pasture management (grazed versus hayed) is the primary factor controlling the rate of decomposition, whereas fertilization has a secondary role. The sigmoid model captures realistically the different phases of decomposition detected over a year, namely stationary at conditions of low temperature (later autumn and winter), accelerated at increasing temperature and humidity (transition from spring to summer) and disaccelerated when residual organic matter becomes less profitable and weather conditions more stringent (summer and earlier autumn).","palabras_clave":"CHACO|SIGMOID MODEL|GRAZING|CATTLE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18623,"idioma_id":4,"titulo":"Swimming and swarming motility properties of peanut-nodulating rhizobia","resumen":"Motility allows populations of bacteria to rapidly reach and colonize new microniches or   microhabitats. The motility of rhizobia (symbiotic nitrogen-fixing bacteria that nodulate legume   roots) is an important factor determining their competitive success. We evaluated the effects of   temperature, incubation time, and seed exudates on swimming and swarming motility of five   strains of Bradyrhizobium sp. (peanut-nodulating rhizobia). Swimming motility was increased by   exudate exposure for all strains except native Pc34. In contrast, swarming motility was increased   by exudate exposure for native 15A but unchanged for the other four strains. All five strains   displayed the ability to differentiate into swarm cells. Morphological examination by scanning   electron microscopy showed that the length of the swarm cells was variable, but generally   greater than that of vegetative cells. Our findings suggest the importance of differential motility   properties of peanut-nodulating rhizobial strains during agricultural inoculation and early steps  of symbiotic interaction with the host.","palabras_clave":"swimming|sarming|peanut|rhizobia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18624,"idioma_id":4,"titulo":"Representation equivalence and p-spectrum of constant curvature space forms","resumen":"We study the p-spectrum of a locally symmetric space of constant curvature GX, in connection with the right regular representation of the full isometry group Iso of X on L^2(GIso)_{tau_p}, where tau_p is the complexified p-exterior representation of O(n) on igwedge^p(R^n)_C.We give an expression of the multiplicity d_{lambda(p,G)} of the eigenvalues of the p-Hodge-Laplace operator in terms of multiplicities n_{G(pi)} of specific irreducible unitary representations of Iso.As a consequence, we extend results of Pesce for the spectrum on functions to the p-spectrum of the Hodge-Laplace operator on p-forms of GX, and we compare p-isospectrality with tau_p-equivalence for 0For spherical space forms, we show that tau-isospectrality implies tau-equivalence for a class of tau´s that includes the case tau=\tau_p.Furthermore we prove that (p-1) and (p+1)-isospectral implies p-isospectral.For nonpositive curvature space forms, we give examples showing that p-isospectrality is far from implying tau_p-equivalence, but a variant of Pesce´s result remains true. Namely, for each fixed p, q-isospectrality for every 0","palabras_clave":"spectrum|representation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18625,"idioma_id":4,"titulo":"What is microcirculatory shock?","resumen":"Purpose of reviewMicrocirculatory shock is a condition defined by the presence of tissue hypoperfusion despite thenormalization of systemic and regional blood flow. In this article, we discuss the characteristics of themicrocirculation in septic shock, the main form of microcirculatory shock, along with its interaction withsystemic hemodynamics, and the response to different therapies.Recent findingsIn septic shock, microcirculatory abnormalities are common, and more severe in nonsurvivors. In addition,the microcirculation shows a behavior that is frequently dissociated from that of systemic hemodynamics.Therefore, microcirculatory alterations may persist despite correction of systemic hemodynamic variables.Sublingual and intestinal microcirculation might also display divergent behaviors. Moreover, microvascularalterations may improve in response to hemodynamic resuscitation, but the response might depend on theunderlying microcirculatory alterations. Particularly, the response to fluids seems to be related to both itsbasal state and the magnitude of the increase in cardiac output.SummaryThe optimal treatment of microcirculatory shock might require monitoring and therapeutic goals targeted onthe microcirculation, more than in systemic variables. The clinical benefits of this approach should bedemonstrated in clinical trials.","palabras_clave":"microcirculation|resuscitation|septic shock|tissue perfusion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18626,"idioma_id":4,"titulo":"Effects of norepinephrine on tissue perfusion in a sheep model of intra-abdominal hypertension","resumen":"BackgroundThe aim of the study was to describe the effects of intra-abdominal hypertension (IAH) on regional and microcirculatory intestinal blood flow, renal blood flow, and urine output, as well as their response to increases in blood pressure induced by norepinephrine.MethodsThis was a pilot, controlled study, performed in an animal research laboratory. Twenty-four anesthetized and mechanically ventilated sheep were studied. We measured systemic hemodynamics, superior mesenteric and renal blood flow, villi microcirculation, intramucosal-arterial PCO2, urine output, and intra-abdominal pressure. IAH (20 mm Hg) was generated by intraperitoneal instillation of warmed saline. After 1 h of IAH, sheep were randomized to IAH control (n&#8201;=&#8201;8) or IAH norepinephrine (n&#8201;=&#8201;8) groups, for 1 h. In this last group, mean arterial pressure was increased about 20 mm Hg with norepinephrine. A sham group (n&#8201;=&#8201;8) was also studied. Fluids were administered to prevent decreases in cardiac output. Differences between groups were analyzed with two-way repeated measures of analysis of variance (ANOVA).ResultsAfter 2 h of IAH, abdominal perfusion pressure decreased in IAH control group compared to IAH norepinephrine and sham groups (49&#8201;±&#8201;11, 73&#8201;±&#8201;11, and 86&#8201;±&#8201;15 mm Hg, P < 0.0001). There were no differences in superior mesenteric artery blood flow, intramucosal-arterial PCO2, and villi microcirculation among groups. Renal blood flow (49&#8201;±&#8201;30, 32&#8201;±&#8201;24, and 102&#8201;±&#8201;45 mL.min&#8722;1.kg&#8722;1, P < 0.0001) and urinary output (0.3&#8201;±&#8201;0.1, 0.2&#8201;±&#8201;0.2, and 1.0&#8201;±&#8201;0.6 mL.h&#8722;1.kg&#8722;1, P < 0.0001) were decreased in IAH control and IAH norepinephrine groups, compared to the sham group.ConclusionsIn this experimental model of IAH, the gut and the kidney had contrasting responses: While intestinal blood flow and villi microcirculation remained unchanged, renal perfusion and urine output were severely compromised.","palabras_clave":"Intra-abdominal hypertension| Perfusion pressure;|Microcirculation|Renal blood flow|Urinary output"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18627,"idioma_id":4,"titulo":"Multiple cardiometabolic risk factors in the Southern Cone of Latin America: A population-based study in Argentina, Chile, and Uruguay","resumen":"Background  Cardiovascular disease is a major cause of death, and its mortality is increasing in Latin America. However, population-based data on cardiovascular disease risk factors are sparse in these countries.    Methods  A total of 7524 men and women, aged 35 to 74 years old, were recruited between February 2010 and December 2011 from randomly selected samples in 4 cities (Bariloche and Marcos Paz, Argentina; Temuco, Chile; and Pando-Barros Blancos, Uruguay) in the Southern Cone of Latin America. Cardiovascular risk factors were measured using standard methods by trained and certified observers.    Results  Approximately 85.5% of adults ate less than five servings of fruit or vegetables per day, 35.2% engaged in low physical activity, and 29.7% currently smoked cigarettes. The prevalences of obesity, central obesity, hypertension, chronic kidney disease, dyslipidemia, diabetes, and metabolic syndrome were 35.7%, 52.9%, 40.8%, 2.0%, 58.4%, 12.4%, and 37.4%, respectively. The proportion of individuals with &#8805; 3 cardiovascular risk factors, including low intake of fruit and vegetables, low physical activity, current cigarette smoking, obesity or central obesity, hypertension, chronic kidney disease, dyslipidemia, and diabetes, was 68.3%, and the proportion of individuals with &#8805; 3 cardiometabolic risk factors, including obesity or central obesity, hypertension, chronic kidney disease, dyslipidemia, and diabetes, was 22.9%.    Conclusions  Cardiovascular disease risk factors are highly prevalent in the general population in the Southern Cone of Latin America. These data suggest that national efforts on the prevention, treatment, and control of cardiovascular risk factors should be a public health priority in the Southern Cone of Latin America.","palabras_clave":"Cardiovascular disease|Diabetes| Dyslipidemia|Hypertension|Obesity|Risk factors"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18628,"idioma_id":4,"titulo":"Critical coupling layer thickness for positive or negative Goos-Hänchen shifts near the excitation of backward surface polaritons in Otto-ATR systems","resumen":"We present a theoretical analysis of the lateral displacement (Goos?Hänchen shift) of spatially limited beams reflected from attenuated total reflection (ATR) devices in the Otto configuration when backward surface plasmon polaritons are excited at the interface between a positive refractive index slab and a semi?infinite metamaterial with a negative refractive index. First, the stationary phase approximation and a phenomenological model based on the properties of the complex poles and zeroes of the reflection coefficient are used to demonstrate that: (i) the excitation of backward surface waves can lead to both negative and positive (and not exclusively negative) Goos?Hänchen shifts, and (ii) the sign of the shift depends on whether the value of the coupling layer thickness is higher or lower than a critical value characteristic of the ATR structure. Then, these findings are verified through rigorous calculations of the spatial structure of the reflected beam. For incident beams with a Gaussian profile, the lateral shift calculated as the first moment of the field distribution of the reflected beam agrees quite well with the predictions of approximate analysis. Near the resonant excitation of the backward surface plasmon polariton, large (negative or positive) Goos?Hänchen shifts are obtained, along with a splitting of the reflected beam.","palabras_clave":"METAMATERIALS|COLLECTIVE EXCITATIONS|OPTICAL PROPERTIES OF SURFACES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18629,"idioma_id":4,"titulo":"Tunable plasmonic enhancement of light scattering and absorption in graphene-coated subwavelength wires","resumen":"  The electromagnetic response of subwavelength wires coated with a graphene monolayer illuminated by a linearly polarized plane waves is investigated. The results show that the scattering and extintion cross-sections of the coated wire can be dramatically enhanced when the incident radiation resonantly excites localized surface plasmons. The enhancements occur for p?polarized incident waves and for excitation frequencies that correspond to complex poles in the coefficients of the multipole expansion for the scattered field. By dynamically tuning the chemical potential of graphene, the spectral position of the enhancements can be chosen over a wide range.","palabras_clave":"OPTICAL PROPERTIES OF GRAPHENE|COLLECTIVE EXCITATIONS|OPTICAL CONSTANTS|GRAPHENE|ELECTRON STATES AND COLLECTIVE EXCITATIONS IN MULTILAYERS, QUANTUM WELLS, MESOSCOPICS AND NANOSCALE SYSTEMS|OPTICAL PROPERTIES OF SURFACES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18630,"idioma_id":5,"titulo":"Perfil de sensibilidad antifúngica in vitro de Scopulariopsis brevicaulis aislados de onicomicosis","resumen":"Se ha estudiado el perfil de actividad antifúngica in vitrode amorolfina (AMR), bifonazol (BFZ), clotrimazol (CLZ), econazol(ECZ), fluconazol (FNZ), itraconazol (ITZ), ketoconazol(KTZ), miconazol (MNZ), oxiconazol (OXZ), tioconazol (TCZ) yterbinafina (TRB) frente a 26 aislamientos clínicos de Scopulariopsisbrevicaulis obtenidos de muestras clínicas de pacientescon onicomicosis, por medio de un método estandarizado demicrodilución. A pesar de que este hongo filamentoso ha sidodescrito como resistente frente a un amplio espectro de antifúngicos,los datos obtenidos muestran una mejor actividadfungistática in vitro de AMR, OXZ y TRB (0,08; 0,3 y 0,35 mg\/L,respectivamente) en comparación con la de CLZ (0,47 mg\/L),ECZ (1,48 mg\/L), MNZ (1,56 mg\/L, BFZ (2,8 mg\/L), TCZ (3,33mg\/L), KTZ (3,73 mg\/L). FNZ (178,47 mg\/L) e ITZ (4,7 mg\/L) mostraronuna reducida actividad antifúngica in vitro. Las CMIs obtenidasmuestran la reducida sensibilidad in vitro en general deS. brevicaulis a los antifúngicos utilizados y que son de posibleuso para el tratamiento de las onicomicosis con la excepción deAMR, OXZ y TRB.","palabras_clave":"Scopulariopsis brevicaulis|sensibilidad|tratamiento|onicomicosis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18631,"idioma_id":4,"titulo":"Experimental and analytical study of the motion of a sphere falling along an inclined plane in still water","resumen":"In this work, the transient regime of motion of a sphere, that falls along aninclined smooth plane, submerged in still water, is studied experimental andanalytically. Several experiments were performed, with spheres of differentdiameters and densities, and two slope angles. The measurements show thatthe motion of the sphere presents two well dened stages: a transitionalregime, where the sphere rapidly accelerates from rest, and an asymptoticregime, where the sphere moves with constant velocity. Closed expressions,for the position and velocity of the sphere as functions of time, are obtainedby direct integration of the motion equations. This theoretical analysis isbased on the empirical correlation for the drag coefficient as a function ofthe Reynolds number of the sphere, that was proposed by Chhabra andFerreira [2] for the experimental data set of Jan and Chen [1]. The analyticalsolution shows good agreement with experimental results, for a wide rangeof experimental conditions.","palabras_clave":"SUBMERGED INCLINED PLANE|ROLLING SPHERE|ACCELERATED MOTION|TERMINAL VELOCITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18632,"idioma_id":4,"titulo":"Charcoal production in the Argentine Dry Chaco: Where, how and who?","resumen":"Charcoal production has been widespread in the past and is still common where poor societies and dry forests coexist. For the Dry Chaco in South America, one of the largest remaining dry forests of the world, we describe the geographical distribution, type of production systems, environmental and social context and output of charcoal based on remote sensing (charcoal kiln detection); together with existing environmental (forest cover\/biomass), social (population density, poverty), and infrastructure (roads) data. While most of the region has low kiln densities (b1 kiln every 1000 km2), foci of higher production were found in the north of Santiago del Estero and the west of Chaco provinces (N1 kiln every 5 km2). Individual or small groups (up to three units) prevail over the regions (58.2% of all kiln sites), frequently associatedwith a forest land cover. Large groups of kilns (&#8805;12 units, 15.5% of all kilns) were associated with land cleared for cultivation. For a subset of kiln sites for which forest biomass data was available, we found that typical kiln sites (1?3 kilns) had half of the average biomass of the region within a radius of 125 m. Although charcoal production in thewhole region has been stable for 50 years, a strong redistribution from richer to poorer provinces has taken place. At the county level, kiln density and charcoal production records showed a linear association that suggests an average output of 11 tons of charcoal per year per kiln. Comparing counties with high vs. low charcoal production with similarly high forest cover, the first had higher population density and poverty levels. Today small scale charcoal production by poor rural people represents the only significant use of forests products that provides some market incentivefor their preservation. However this situation is associated with marginal social conditions, inefficient production, and forest degradation. Developing charcoal production under environmentally and socially virtuous conditions should be seen as a unique opportunity and an urgent challenge in the face of the fast deforestation of dry forests.","palabras_clave":"Charcoal kilns|Dry Forest|Biomass|Energy|Forest development"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18633,"idioma_id":4,"titulo":"Understanding erratic seedling emergence in perennial grasses using physiological models and field experimentation","resumen":"Year-to-year variability in field seedling emergence in arid rangelands poses questions about the viability of perennial grasses threatened by overgrazing. There are practical difficulties in estimating long-term seedling emergence for perennial species with erratic behavior (high temporal variability). We present a novel approach combining seed germination studies, modeling, and field experiments to estimate long-term germination probability using Poa ligularis as a perennial grass model. Additional objectives were to evaluate: (i) germination requirements of different P. ligularis populations, (ii) field emergence behavior at two extreme locations within the distributional range in the southern region, and (iii) the influence of microsite or local soil on field emergence. Germination parameters were obtained from 8 populations collected across a 12° latitude transect. Germination parameters were combined with a soil water model to estimate long-term germination (used as a proxy of field emergence) in the southernmost location. Germination requirements differed across populations and correlated with environmental conditions of collection sites, demonstrating ecological significance. Field experiments showed very low emergence. Simulations for the southern location indicated erratic emergence. Fifty percent of the years had nil simulated field emergence and the magnitude of the events, when occurred, was small. The magnitude of these events depended on the population, demonstrating an additional genetic constraint. Erratic field emergence arises from the mismatch between environmental conditions and germination requirements. Knowing favorable climatic conditions triggering seed germination (and thus emergence) events are key for opportunistic management of species with this erratic behavior","palabras_clave":"Geographic range|Opportunistic management|Patagonia|\u0002 Rangeland ecology\u0002|Restoration"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18634,"idioma_id":5,"titulo":"Del exilio a los nuevos paradigmas: los intelectuales argentinos de la comunicación en México (de Controversia a Comunicación y cultura)","resumen":"Nos proponemos en este trabajo analizar las relaciones entre la llamada ?revolución conceptual? de la izquierda que produjo en el exilio una serie de intelectuales argentinos en México (1974-1983) y la reformulación de un pensamiento sobre la comunicación que ?teniendo en parte a los mismos promotores? produjo por entonces una serie de reformulaciones epistémicas en la que por entonces era un campo de estudios emergente y en proceso de consolidación. Estos desplazamientos contribuirían a configurar su agenda en Argentina en los años siguientes y a promover su institucionalización en el país. Más concretamente, analizaremos las intervenciones que desplegaron los ?intelectuales de la comunicación? en las revistas Controversia (1979-1981) y Comunicación y cultura en su etapa mexicana (1982-1985).","palabras_clave":"historia intelectual|estudios en comunicación|intelectuales|exilio mexicano"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18635,"idioma_id":4,"titulo":"The State Duty to Protect from Business-Related Human Rights Violations in Water and Sanitation Services: Regulatory and BITs Implications","resumen":"The Human Right to Water and Sanitation HRWS has called primary attention since General Comment No. 15 (GC 15) issued in 2002 by the UN Committee on Economic, Social, and Cultural Rights, CESCR interpreted articles 11 and 12 of the International Covenant on Economic, Social, and Cultural Rights (ICESCR). Since then, much has been written on this human right, but very little on the existing linkage between it and private corporations providing public water and sanitation services (WSS), and even less on the regulatory and Bilateral Investment Treaties (BITs) implications of the state´s duty to protect this right. This article will therefore study the state´s duty to protect from business- related human rights violations in the specific field of WSS from two interrelated perspectives. On one hand, the domestic regulatory front, which raises questions such as: Should regulation of private water and sanitation companies be based on human rights standards? If so, to what extent? What are the concrete regulatory implications of the two previous responses? Has existing case law outlined minimum regulatory standards based on international human rights norms? On the other hand, in terms of international liability, the following questions are crucial: How should we interpret BITs that protect foreign companies providing water and sanitation in light of the states duty to protect from business-related human rights violations? How to reconcile the states BITs commitments with its obligations under human rights treaties in WSS? Do we need to reconcile them at all?(SciELO \/ ProQuest - Central to Research Around the World \/ EconLit - American Economic Association Publications \/ PUBLINDEX; A2 \/ CLASE (Citas Latinoamericanas en Ciencias Sociales y Humanidades) \/ Latindex (Universidad Autónoma de México) \/ Dialnet \/ Redalyc Ebsco Host: Fuente Académica \/ Peace Palace Library (La Haya).","palabras_clave":"HUMAN RIGHTS |WATER AND SANITATION SERVICES|THE STATE DUTY TO PROTECT|BIT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18636,"idioma_id":5,"titulo":"Estratigrafía y evolución del Complejo Volcánico Cerro Blanco, Puna Austral, Argentina","resumen":"El Complejo Volcánico Cerro Blanco se ubica en la provincia deCatamarca en el extremo sur del altiplano Andino y ha sido interpretadocomo un sistema de calderas anidadas con abundantes depósitospiroclásticos y actividad dómica asociada. Todos sus productos sonde composición riolítica\/riodacítica y las edades radiométricas disponiblespermiten asignarle una edad Pleistoceno Medio-Holoceno.Actualmente tiene asociado un pequeño campo geotermal activo yregistra una subsidencia de 0.87 cm\/año. A pesar de existir numerososestudios regionales sobre el volcanismo del extremo sur del altiplanoAndino, la estratigrafía de detalle de la mayoría de los centros eruptivosde la región es poco conocida. En este estudio se presenta un nuevoesquema estratigráfico para el Complejo Volcánico Cerro Blanco basadoen la utilización combinada de unidades litoestratigráficas juntocon el concepto de unidades estratigráficas limitadas por discordancias(Unconformity Bounded Stratigraphic Units) sumados a la aplicación deunidades de actividad volcánica y litosomas. Los resultados obtenidospermitieron reconstruir la evolución del Complejo Volcánico CerroBlanco en tres épocas eruptivas principales que constituyen un periodoeruptivo: i) Época eruptiva Cortaderas (Pleistoceno Medio), representadapor el sintema homónimo y caracterizada por erupciones de tipoexplosivo, con un estilo eruptivo con escaso desarrollo vertical de lacolumna eruptiva (boiling over) y abundante generación de corrientesde densidad piroclásticas (Ignimbritas Barranca Blanca y Carachi). Lafuente de estas erupciones se desconoce. ii) Época eruptiva Campo dela Piedra Pómez (Pleistoceno Superior), representada por el sintemahomónimo y formada por, al menos, una erupción. Esta erupción fuede tipo explosivo y tuvo dos fases eruptivas principales representadaspor los subsintemas UI y UII. El estilo eruptivo fue de rebosamiento(boiling over) con escaso desarrollo de la columna eruptiva y generaciónde abundantes corrientes de densidad piroclásticas (IgnimbritaCampo de la Piedra Pómez). Se propone un modelo preliminar en elcual la fuente de esta erupción podría estar asociada a la actividadde una depresión volcanotectónica. iii) Época eruptiva Cerro Blanco(Holoceno), representada por el sintema homónimo el cual incluyela actividad pre-, sin- y poscaldera Cerro Blanco (subsintemas CB1,CB2 y CB3 respectivamente). La actividad volcánica precaldera fuede tipo efusivo y está representada en forma indirecta por depósitosde bloques y ceniza. La actividad sincaldera fue de tipo explosivo conun estilo eruptivo pliniano\/subpliniano con generación de corrientesde densidad piroclásticas simultáneas, representada por la IgnimbritaCerro Blanco y depósitos de caída asociados. La actividad poscalderafue de tipo efusivo\/explosivo y está representada por domos poscalderay por los depósitos de bloques y ceniza, y de caída vulcanianosasociados. Los resultados obtenidos indican que el Complejo VolcánicoCerro Blanco durante los últimos 100 mil años tuvo, al menos, doserupciones de gran magnitud (Índice de Explosividad Volcánica &#8805; 6)y en particular la erupción asociada al colapso de la Caldera CerroBlanco constituiría uno de los eventos volcánicos holocenos de mayormagnitud en los Andes Centrales. Finalmente se considera que losresultados presentados en esta contribución podrían coadyuvar a laevaluación de la peligrosidad potencial asociada a una reactivación delComplejo Volcánico Cerro Blanco.","palabras_clave":"volcanismo félsico|Cuaternario;|estratigrafía secuencial|peligrosidad volcánica|Andes Centrales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18637,"idioma_id":5,"titulo":"Evaluación del nivel de daño en el material genético de niños de la provincia de Córdoba, expuestos a plaguicidas.","resumen":"Introduction.In the past decades, several authors  have investigated the genotoxicity caused by  exposure to chemicals, but there are no reports  on studies analyzing such effects on children  in Argentina. The objective of this study was  to establish the micronucleus frequency in  exfoliated buccal mucosa cells in children from  urban areas with environmental exposure  (through inhalation) and to compare it with the  micronucleus frequency in children from urban  regions far from areas subjected to spraying.  Population and Methods.Fifty children living in  the town of Marcos Juárez (Córdoba) at different  distances from pesticide spraying areas and  twenty-five children from the city of Río Cuarto  (Córdoba), who are considered not exposed to  pesticides, were studied; the micronucleus assay  in buccal mucosa cells was used.  Results. A significant difference was observed  between exposed children living less than 500 m  from areas subjected to spraying and those who  were not exposed. Forty percent of exposed  children suffer some type of persistent condition,  which may be associated with chronic exposure  to pesticides.  Conclusions. Results indicate that genotoxicity  is present in a group of children compared to  the other one, and highlight the importance of  the micronucleus assay in buccal mucosa cells  for genetic biomonitoring and public health  surveillance. This assay is capable of detecting  a level of damage that can be reversible.","palabras_clave":"micronúcleos|inducción genotóxica|mucosa bucal|exposición a plaguicidas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18638,"idioma_id":5,"titulo":"Migración internacional en la Ciudad de Buenos Aires: un análisis socioespacial de su distribución según tipos de hábitat","resumen":"En el marco de la pregunta por las diferencias y desigualdades metropolitanas, este artículo sepropone estudiar la distribución espacial de la población extranjera en la Ciudad de Buenos Airesa partir de una tipología de contextos urbanos o tipos de hábitat, definidos en función del períodode urbanización y la forma de producción del espacio habitacional. Tomando como fuenterelevamientos previos y datos del Censo Nacional de Población, Hogares y Viviendas 2010, serealiza un análisis cuantitativo que indaga en cómo se articula la diferenciación por condiciónmigratoria con estos entornos que conforman la estructura socio-espacial de la Ciudad.INDEXADA EN: Biblioteca Virtual de CLACSO; &nbsp;Clase (Citas Latinoamericanas en Ciencias  Sociales y Humanidades); &nbsp;Conacyt (Indice  de Revistas Mexicanas de Investigación Científica y Tecnológica); DIALNET;  Directory of Open Access Journals (DOAJ); e-Revistas; HAPI (Hispanic American  Periodicals Index); HLAS (Handbook of Latin American Studies); IBR (Internationale Bibliographie  der Rezensionen Wissenschaftlicher Literatur); &nbsp;International Bibliography of the Social  Sciences; JSTOR; Latindex-Catálogo; Latindex-Directorio; MECS (México -  Ciencias Sociales); P A I S  International (Public Affairs Information Service); Periodicals Index Online;  PopLine; Population Index; Red ALyC; Scopus; Sociological Abstracts;  Ulrich´s  ","palabras_clave":"TIPOS DE HÁBITAT|CONTEXTOS URBANOS|MIGRACIÓN INTERNACIONAL|DISTRIBCIÓN ESPACIAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18639,"idioma_id":4,"titulo":"Effect of resource spatial correlation and Hunter-Fisher-Gatherer mobility on social cooperation in Tierra del Fuego","resumen":"This article presents an agent-based model designed to explore the development of cooperation in hunter-fisher-gatherer societies that face a dilemma of sharing an unpredictable resource that is randomly distributed in space. The model is a stylised abstraction of the Yamana society, which inhabited the channels and islands of the southernmost part of Tierra del Fuego (Argentina-Chile). According to ethnographic sources, the Yamana developed cooperative behaviour supported by an indirect reciprocity mechanism: whenever someone found an extraordinary confluence of resources, such as a beached whale, they would use smoke signals to announce their find, bringing people together to share food and exchange different types of social capital. The model provides insight on how the spatial concentration of beachings and agents? movements in the space can influence cooperation.  We conclude that the emergence of informal and dynamic communities that operate as a vigilance network preserves cooperation and makes defection very costly.","palabras_clave":"COOPERATION|AGENT-BASED MODEL|HUNTER-GATHERERS|TIERRA DEL FUEGO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18640,"idioma_id":4,"titulo":"Reproductive biology and energy allocation of the sea star Cosmasterias lurida (Echinodermata: Asteroidea) from the Beagle Channel, Tierra del Fuego, Argentina","resumen":"Seasonal fluctuations in environmental factors at high-latitude marine regions have a strong influence on the reproductive cycles of echinoderms. The purposes of this study on a population of Cosmasterias lurida in the Beagle Channel are to describe the reproductive cycle through histological analyses, to characterize the pattern of gonad and somatic indices, to determine the energy content of different organs and their temporal variation and to establish the pattern of energy allocation. During the study period, from August 2010 to June 2011, four seasonal samplings were performed in the subtidal zone of Ushuaia Bay. Indices (gonad, pyloric caeca and stomach), gonadal histology, organic matter and calorimetric measurements were determined. Gametogenesis begins in February and continues until June when oocyte size increases. The gonadal maximum development and gamete releasing take place between August and December. Temporal variation of energetic reserves in gonads occurs through the variation in gonad mass, with a GI major peak and energy content during August. Stomach and pyloric caeca show their maximum energy accumulation during June, while decrease of organic matter of the body wall takes place from August to December. The population of C. lurida from Beagle Channel suggests an annual reproductive cycle with two maturation events and the influence of water temperature on maturation and releasing of gametes. Different patterns of energy allocation to gonads between sexes were observed, with a greater energy investment in females than in males. Pyloric caeca, stomach and body wall were proposed as energy reservoirs for gonadal maturation and spawning.","palabras_clave":"Energy alocation|Equinoderms|Beagle Channel"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18641,"idioma_id":4,"titulo":"Changes in the loading conditions induced by vagal stimulation modify the myocardial infarct size through sympathetic-parasympathetic interactions","resumen":"In a previous research, we described that vagal stimulation increases the infarct size by sympathetic co-activation. The aim of this study was to determine if hemodynamic changes secondary to the vagal stimulation are able to activate sympathetic compensatory neural reflexes, responsible for increasing the infarct size. A second goal was to determine if intermittent vagal stimulation avoids sympathetic activation and reduces infarct size by muscarinic activation of the Akt\/glycogen synthase kinase 3 &#946; (GSK-3&#946;) pathway. Rabbits were subjected to 30 min of regional myocardial ischemia and 3 h of reperfusion without vagal stimulation, or the following protocols of right vagus nerve stimulation for 10 min before ischemia: (a) continuous vagal stimulation and (b) intermittent vagal stimulation (cycles of 10 s ON\/50 s OFF). Continuous vagal stimulation increased the infarct size (70.7&#8201;±&#8201;4.3 %), even after right vagal section (68.6&#8201;±&#8201;4.1 %) compared with control group (52.0&#8201;±&#8201;3.7 %, p&#8201;<&#8201;0.05). Bilateral vagotomy, pacing, and esmolol abolished the deleterious effect, reaching an infarct size of 43.3&#8201;±&#8201;5.1, 43.5&#8201;±&#8201;2.1, and 46.0&#8201;±&#8201;4.6 % (p&#8201;<&#8201;0.05), respectively. Intermittent stimulation reduced the infarct size to 29.8&#8201;±&#8201;3.0 % (p&#8201;<&#8201;0.05 vs I\/R). This effect was blocked with atropine (50.2&#8201;±&#8201;3.6 %, p&#8201;<&#8201;0.05). Continuous vagal stimulation induced bradycardia and increased the loading conditions and wall stretching of the atria. These changes provoked the co-activation reflex of the sympathetic nervous system, observed by the rise in plasmatic catecholamine levels, which increased the infarct size. Sympathetic co-activation was abolished by continuous vagal stimulation with constant heart rate or parasympathetic deafferentation. Intermittent vagal stimulation attenuated the sympathetic tone and reduced the infarct size by the muscarinic activation of the Akt pathway and GSK-3&#946; inhibition. Continuous stimulation only phosphorylated Akt and GSK-3&#946; when esmolol was administered.","palabras_clave":"VAGAL STIMULATION|MYOCARDIAL INFARCTION|RABBITS|MYOCARDIAL PROTECTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18642,"idioma_id":4,"titulo":"A complete radio study of SNR G15.4+0.1 from new GMRT observations","resumen":"Aims. The supernova remnant (SNR) G15.4+0.1 is considered to be the possible counterpart of the &#947;-ray source HESS J1818&#8722;154.With the goal of getting a complete view of this remnant and understanding the nature of the &#947;-ray flux, we conducted a detailedradio study that includes the search for pulsations and a model of the broadband emission for the SNR G15.4+0.1\/HESS J1818&#8722;154system.Methods. Low-frequency imaging at 624 MHz and pulsar observations at 624 and 1404 MHz towards G15.4+0.1 were carried outwith the Giant Metrewave Radio Telescope (GMRT). We correlated the new radio data with observations of the source at X-ray andinfrared wavelengths from XMM-Newton and Herschel observatories, respectively. To characterize the neutral hydrogen (HI) mediumtowards G15.4+0.1, we used data from the Southern Galactic Plane Survey.We modelled the spectral energy distribution (SED) usingboth hadronic and leptonic scenarios.Results. From the combination of the new GMRT observations with existing data, we derived a continuum spectral index &#945; =&#8722;0.62 ± 0.03 for the whole remnant. The local synchrotron spectra of G15.4+0.1, calculated from the combination of the GMRT datawith 330 MHz observations from the Very Large Array, tends to be flatter in the central part of the remnant, accompanying the regionwhere the blast wave is impinging molecular gas. No spectral index trace was found indicating the radio counterpart to the pulsar windnebula proposed from X-ray observations. In addition, the search for radio pulsations yielded negative results. Emission at far-infraredwavelengths is observed in the region where the SNR shock is interacting with dense molecular clumps.We also identified HI featuresforming a shell that wraps most of the outer border of G15.4+0.1. Characteristic parameters were estimated for the shocked HI gas.We found that either a purely hadronic or leptonic model is compatible with the broadband emission known so far.","palabras_clave":"SNR G15.4|HESS J1818-154|SUPERNOVA REMNANTS-GAMMA RAYS|RADIO CONTINUUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18643,"idioma_id":4,"titulo":"The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a host factor required for dengue virus and Junín virus multiplication","resumen":"Heterogeneous nuclear ribonucleoproteins (hnRNPs) are cellular factors involved in the replication of several viruses. In this study we analyzed the expression and intracellular localization of hnRNP A2 and hnRNP K in cell cultures infected with two viruses that cause human hemorrhagic fevers: dengue virus type 2 (DENV-2) and Junín virus (JUNV). We determined that DENV-2 promoted the cytoplasmic translocation of hnRNP K and to a lesser extent of hnRNP A2, meanwhile, JUNV infection induced an increase in hnRNP K cytoplasmic localization whereas hnRNP A2 remained mainly in the nucleus of infected cells. Both hnRNP K and hnRNP A2 were localized predominantly in the nucleus of JUNV persistently-infected cells even after superinfection with JUNV indicating that persistent infection does not alter nucleo-cytoplasmic transport of these hnRNPs. Total levels of hnRNP K expression were unaffected by DENV-2 or JUNV infection. In addition we determined, using small interfering RNAs, that hnRNP K knockout inhibits DENV-2 and JUNV multiplication. Our results indicate that DENV-2 and JUNV induce hnRNP K cytoplasmic translocation to favor viral multiplication.","palabras_clave":"VIRUS DENGUE|VIRUS JUNIN|HNRNPK"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18644,"idioma_id":4,"titulo":"Exploring the photo-stability of the {Ru(py)4}2+ fragment","resumen":"Mononuclear Ru(II) tetrakis-pyridine species of general formula trans-[(Cl)Ru(py)4(X)]n+ (X = Cl&#8722;, MeCN and CO) are thermally inert toward ligand exchange reactions at room temperature, but undergo substitution under photolysis conditions. The carbonyl derivative trans-[(Cl)RuII(py)4(CO)]+ was specifically synthesized for this report by the direct reaction between trans-[(Cl)RuII(py)4(Solv)]+ and CO in acetone and isolated as a PF6&#8722; salt. Stationary photolysis experiments in MeCN allowed recording changes in the absorption profiles along time providing quantitative values for the quantum yields of the different photo-processes, which involve the consecutive loss of CO, MeCN or pyridine ligands. There is no evidence of photo-release of a chloride anion in none of the molecules under study. For X = CO and MeCN the photo-release of X is favored over the substitution of a pyridine molecule.","palabras_clave":"Ruthenium|Photochemistry|Reactivity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18645,"idioma_id":5,"titulo":"?Evaluation of Salinity Tolerance Indices in seedling of maize (Zea mays L.)?","resumen":"The aims of this research were: to study the application of different tolerance Indices in traits measured in maize seedlings and to assess their possible use in the identification of genotypes tolerant to salinity. Sixty eight accessions were tested in two environments (0 and 100mM NaCl). We recorded length for radicle, shoot and third leaf and dry weight for root and shoot. Six stress tolerance indices were included: stress susceptibility (SSI), stress tolerance index (STI), stress tolerance (TOL), geometric mean productivity (GMP), mean productivity (MP) and yield stability index (YSI. Saline environments show a great spatial variation in relation to the salt concentration, for this reason it would be important to identify genotypes with stable behavior in a variety of saline soils. The biplot method allowed clustering accessions, traits measured in stress and non stress environment and salt tolerance Indexes in a same graphic, and showed that GMP, MP and STI indexes were the ones who helped identify the high yielding (group A genotype) and stable accessions, characterized by a high expression of these characters in both environments. Principal Component method showed that shoot dry weight and root length had the highest contribution and both were associated with these above indices in salinity. Therefore, in this study the accessions: 1, 7, 30, 33, 43 and 45 had stable values for the traits root length and shoot dry weight. Within this group the 30 and 33 entries were superior (bellowing to Group A genotypes) because they had the highest PC1 scores but its PC2 scores were rather small for the most of the variables.","palabras_clave":"Zea mays |seedling growth|selection|salinity tolerance|stability"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18646,"idioma_id":4,"titulo":"Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts","resumen":"          Layered double hydroxides and Zn layered  hydroxide salts present different physicochemical properties derived from their  dissimilar structure and composition. In this work these aspects are studied to  understand their different behavior as drug carriers. LDHs and LHSs  intercalated with three different NSAIDs (Ibu, Nap and Ket) were obtained. The  structure and bonding of the solids was determined by chemical analysis, PXRD,  FT-IR and RMN. Also, the interfacial properties (potential zeta and  hydrophillic\/hydrophobic character) of the hybrids, as well as the drug release  profiles were comparatively studied. The drugs were bonded by electrostatic interactions to LDH  layers while coordinated bonding was produced in the case of LHSs, whose  structure was different for ibuprofen containing hybrid and for those  containing naproxen or ketoprofen. The different bonding, together with the  higher anion density between LHS layers produced more chrystalline solids with  larger basal spacings than those obtained for LDHs. The differences in  structure, bonding and composition explained the surface charging behavior and  the larger solubility of LHS layers explained their faster drug release in  neutral media. Finally, the loose arrangement in the hybrids compared to that  of the pure drug explained the solubility increase obtained in acid media.  ","palabras_clave":"Layered double hydroxides|Layered hydroxide salts|anion exchange|ligand exchange|charging behavior"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18647,"idioma_id":4,"titulo":"Understanding diversity patterns in  bacterioplankton communities from a Sub- Antarctic peatland","resumen":"Bacterioplankton communities inhabiting peatlands have the potential to influence local ecosystem functions. However, most microbial ecology research in such wetlands has been done in ecosystems (mostly peat soils) of the Northern Hemisphere, and very little is known of the factors that drive bacterial community assembly in other regions of the world. In this study we used high-throughput sequencing to analyse the structure of the bacterial communities in five pools located in a sub-Antarctic peat bog (Tierra del Fuego, Argentina), and tested for relationships between bacterial communities and environmental conditions. Bacterioplankton communities in peat bog pools were diverse and dominated by members of the Proteobacteria, Actinobacteria, Bacteroidetes and Verrucomicrobia. Community structure was largely explained by differences in hydrological connectivity, pH and nutrient status (ombrotrophic vs minerotrophic pools). Bacterioplankton communities in ombrotrophic pools showed phylogenetic clustering, suggesting a dominant role of deterministic processes in shaping these assemblages. These correlations between habitat characteristics and bacterial diversity patterns provide new insights into the factors regulating microbial populations in peatland ecosystems.","palabras_clave":"BACTERIOPLANKTON|BOG POOLS|DIVERSITY|PHYLOGENETIC CLUSTERING|PYROSEQUENCING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18648,"idioma_id":4,"titulo":"Quasi-deterministic population dynamics in stochastic coupled maps","resumen":"We studied the stochastic dynamics of coupled map lattices for small local populations.Quasi-deterministic dynamics is lost when considering one isolated population or two populations linked by dispersal. In a one-dimensional ring linked by closest neighbors some intermittent synchronization is observed. Finally we show that in two-dimensional lattices long-term synchronization take place above a critical value of the dispersal probability and the system displays a quasi-deterministic dynamics.","palabras_clave":"Logistic map|dispersal|phase transition|collective dynamics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18649,"idioma_id":4,"titulo":"In vitro steroid-induced meiosis in Rhinella arenarum oocytes: role of pre-MPF activation","resumen":"In this work we showed the relationship between seasonal periods and the response of R. arenarum follicles and oocytes to different steroids. Using in vitro germinal vesicle breakdown (GVBD) assays, we demonstrated that P4 is the main steroid capable of inducing maturation in R. arenarum oocytes and follicles. In the second part of this work we showed that androgens can activate pre-maturation promoting factors (pre-MPFs) such as P4, by cytoplasm microinjection experiments. The results indicated that the steroids assayed induced oocyte and follicle maturation in a dose- and time-dependent manner. In oocytes, P4 was the most efficient steroid as a maturation inducer (EC50 of the reproductive period, 6 nM, EC50 of the non-reproductive period &#8773; 30 nM). Androgens (DHEA, dehydroepiandrosterone; T, testosterone; and AD, androstenedione) were less efficient maturation inducers than P4 (EC50 reproductive period &#8773; 50, 120 and 600 nM respectively). Similar results were obtained with intact follicles in both seasonal periods. Although the response of follicles to the different androgens was variable, in no case was it above the above the response induced by P4. Independently of the season, oocytes and follicles incubated in P4, P5 and T underwent GVBD after 6-10 h while oocytes and follicles incubated in DHEA and AD matured more slowly. Furthermore, we demonstrated that microinjection of mature cytoplasm from androgen-treated oocytes is sufficient to promote GVBD in immature recipient oocytes (DHEA, 57 ± 12%; AD, 60 ± 8%; T, 56 ± 13%). Thus, androgens such as DHEA, T and AD are as competent as P4 to activate pre-MPF.","palabras_clave":"STEROID-PRODUCTION|MPF ACTIVATION|OOCYTE|RHINELLA ARENARUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18650,"idioma_id":4,"titulo":"The effect of economic integration and institutional quality of trade agreements on trade margins: evidence for Latin America","resumen":"This paper studies the effects of economic integration, as well as the institutional quality of existing trade agreements in Latin America, on the margins of trade. The analysis is performed on bilateral exports of goods from eleven member countries of the Latin American Integration Association (LAIA) over the period 1962-2009. We distinguish the effects of different levels of integration on trade margins and different ?timing?; and we go further by considering the effect of institutional quality of trade agreements on different sectors. Our results provide evidence about the benefits of regional integration, which is in line with LAIA members? development and industrialization objectives.","palabras_clave":"Integración Regional|Calidad Institucional|margenes de comercio"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18651,"idioma_id":4,"titulo":"Regional versus global production networks: Where does Latin America stand?","resumen":"This paper quantifies the effects of the Latin American Integration Association (LAIA) and the Southern Common Market (Mercosur) on the trade of intermediate goods and also on the trade of final goods. It is the first paper to investigate whether increasing imports of intermediate goods from different regions to Latin America have led to higher exports of final and intermediate goods. The paper uses sectoral data for trade in goods between eleven LAIA members over the period 1991-2008. The main results indicate evidence of increasing regional production networks, which have strengthened in the 2000s. Moreover, the findings show evidence of the emergence of global production networks, especially with respect to intermediate imports from China.","palabras_clave":"production networks|intermediate goods|trade integration|Latin America"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18652,"idioma_id":5,"titulo":"La epistemología 'interna' de la investigación y su significado formativo para los psicólogos","resumen":"Este  trabajo pretende justificar la relevancia de los análisis epistemológicos para la formación de los psicólogos, pensando principalmente en la actividad de investigación. En primer lugar, se establece  la especificidad de dicho análisis respecto de otros niveles de la investigación. En segundo lugar, se formulan introductoriamente  algunas  cuestiones meta teóricas, y se esbozan ciertos análisis: Se pone de relieve la importancia del análisis conceptual, buscando eliminar la ambigüedad e imprecisión de las nociones psicológicas;   se reflexiona sobre la intervención   de las  presuposiciones filosóficas en la investigación, según  una perspectiva escisionista y otra dialéctica; se consideran  las condiciones sociales del conocimiento y su relación con la conquista de la objetividad.  Finalmente, y en base a lo analizado, se precisan los rasgos de la actividad meta teórica ?mientras se produce el conocimiento? y su impacto sobre la formación de los psicólogos.  En este sentido, se defiende la adopción de un pensamiento crítico, asumiendo una doble tradición intelectual.","palabras_clave":"epistemología interna|analisis conceptual|marco epistémico|formación de los psicólogos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18653,"idioma_id":5,"titulo":"El proceso de investigación de conocimientos infantiles en psicología genética y antropología","resumen":"En este artículo, reflexionaremos acerca del proceso de investigación de los conocimientos sociales de los niños y niñas a la luz de los abordajes de la psicología genética crítica y la antropología. El estudio está organizado en cinco partes. Primeramente, analizaremos los supuestos epistémicos que orientan las prácticas de investigación sobre los conocimientos. A partir de allí, discutiremos la influencia de los marcos epistémicos sobre la elaboración de las unidades de análisis, revisando las propuestas en el campo de la psicología del desarrollo y en la antropología. Luego, nos centraremos en la problemática de las entrevistas en las aproximaciones etnográficas y psicológicas, para, más adelante, explicitar de qué manera incorporamos las diferentes herramientas metodológicas en nuestras investigaciones empíricas. Por último, presentaremos las principales conclusiones a las que hemos arribado.","palabras_clave":"INVESTIGACIÓN|METODOLOGÍA|CONOCIMIENTO INFANTIL|INTERDISCIPLINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18654,"idioma_id":4,"titulo":"Insecticidal toxicity of  Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and  possible uses according to the metabolic response of flies","resumen":"In a fumigant assay, Musca domestica adults treated with Eucalyptus cinerea EO [LC50= 5.5 mg\/dm3;majority component by SPME?GC: 1,8-cineole (88.5%), -pinene (2%), -terpineol (9%)], died within15 min or less. The terpenes absorbed by the flies and their metabolites, analyzed using SPME fiber, were1,8-cineole (LC50= 3.3 mg\/dm3), -pinene (LC50= 11.5 mg\/dm3), -terpineol (LC50= 36.8 mg\/dm3) and anew component 2,3-dehydro-1,8-cineole, in proportions of 74%, 0.1%, 24.7% and 1.2% respectively. 2,3-Dehydro-1,8-cineole and -terpineol were formed by oxidation of 1,8-cineole mediated by cytochromeP450, as demonstrated by a fumigation assay on flies previously treated with piperonyl butoxide, a P450inhibitor, which showed an increase in toxicity of the EO and 1,8-cineole, supporting its participationin the formation of metabolites. We also demonstrated that 1,8-cineole acts as a P450 inhibitor-likecompound, improving the toxicity of other xenobiotics such as deltamethrin.","palabras_clave":"MUSCA DOMESTICA|1,8-CINEOL|P450|DELTAMETRINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18655,"idioma_id":5,"titulo":"Efecto del extracto acuoso de chañar (Geoffroea decorticans Burkart) sobre Botrytis cinerea,  como posible alternativa para su control durante poscosecha de uva de mesa","resumen":"Botrytis cinerea es un hongo parásito, que produce enfermedades destructivas enmuchos cultivos y causa daños económicos importantes. En vid produce podredumbre blanda de la baya, disminuyendo rendimientos y calidad de uva, mostos y vino. Para asegurar la calidad, se emplean distintas estrategias. Entre estas, la aplicación de fungicidas, que pueden producir efectos adversos en el ambiente y dejar residuos que afectan la salud. Los extractos de plantas son un método de control alternativo válido. Los objetivos de este trabajo fueron determinar el efecto biológico del extracto acuoso de chañar sobre la germinación y crecimiento del tubo germinativo de conidios de B. cinerea y determinar su eficiencia en el control in vivo. Para ello se puso en contacto el extracto a distintas concentraciones, con los conidios del patógeno. Para determinar la eficiencia del control in vivo, sobre racimos de vid cv. Red Globe, se comparó el extracto a  distintas concentraciones con dicloran y difusores de dióxido de azufre. De estos estudios, pudo determinarse que el extracto fue capaz de inhibir la germinación y crecimiento del tubo germinativo de conidios de B. cinerea. En los ensayos in vivo, el extracto disminuyó el porcentaje de bayas afectadas por el patógeno.","palabras_clave":"Botrytis|bioactividad|Geofroea"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18656,"idioma_id":5,"titulo":"Implementación de herramientas y arquitecturas tecnológicas en sectores de la FR Rosario-UTN en el marco de un Modelo de Gestión por Procesos","resumen":"En el presente trabajo se exponen contenidos relacionados con la continuación del proceso de construcción de un Modelo de Gestión por Procesos en Instituciones Universitarias Públicas.  Antecedentes del mismo se pueden verificar en el artículo que forma parte de la publicación de la Secretaría de Ciencia, Tecnología e Innovación Productiva  de la UTN-Facultad Regional Avellaneda en la Revista  ?Rumbos Tecnológicos?, bajo el título ?DESARROLLO DE UN MODELO DE GESTIÓN POR PROCESOS ENFOCADO EN CADENAS DE VALOR EN INSTITUCIONES UNIVERSITARIAS PÚBLICAS. CASO FR ROSARIO-UTN. Setiembre de 2013.  Una vez cumplimentado las etapas previas de análisis del estado del conocimiento de las temáticas involucradas en el proyecto para definir un marco conceptual y metodológico, se llevó adelante el análisis de herramientas actuales para el modelado de procesos de negocio, definición del Proceso de Documentación de Procedimientos y construcción de la primera versión del Manual de Documentación. Habiendo cumplimentado los primeros pasos de concientización, capacitación y relevamiento preliminar, que forman parte del modelo y son imprescindibles para avanzar en el desarrollo del mismo, es que llegamos a presentar los avances logrados en la siguiente etapa del Plan de trabajo, relacionada directamente con la implementación de herramientas y arquitecturas tecnológicas sobre un caso de estudio particular.","palabras_clave":"ESPECIFICACIÓN DE PROCESOS|MODELADO DE PROCESO DE NEGOCIOS|GESTIÓN DE CONTENIDOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18657,"idioma_id":5,"titulo":"El Sector Industrial y Empresario de la Industria del Software y Servicios Informáticos (SSI) en el área de Rosario","resumen":"A partir de la caracterización de los grupos de interés (Avances para la caracterización de los grupos de Interés relacionados con la Industria de Software y Servicios Informáticos en el área Rosario(publicado en la revista Rumbos Tecnológicos en Abril de 2014) relacionadas con la industria del Software y Servicios Informáticos (SSI), continuamos con el análisis específico de cada grupo de interés iniciando las actividades con el Sector Empresario e Industrial de la SSI.  El presente trabajo resume las actividades y los avances realizados en torno al diseño metodológico de la investigación, desarrollo de los instrumentos utilizados para el análisis y primeras evaluaciones y actividades desencadenadas a partir de la puesta en práctica de los instrumentos desarrollados.  El acceso inicial a las empresas para desarrollar el proceso exploratorio se realizó gracias a la colaboración del Polo Tecnológico Rosario.","palabras_clave":"OBSERVATORIO|DESARROLLO REGIONAL|INDUSTRIA DEL SOFTWARE Y SERVICIOS INFORMÁTICOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18658,"idioma_id":4,"titulo":"Integrating transcriptomic and metabolomic analysis to understand natural leaf senescence in sunflower","resumen":"Leaf senescence is a complex process, which has dramatic consequences on crop yield. In sunflower, gap between potential and actual yields reveals the economic impact of senescence.Indeed, sunflower plants are incapable of maintaining their green leaf area over sustained periods. This study characterizes the leaf senescence process in sunflower through a systemsbiology approach integrating transcriptomic and metabolomic analyses: plants being grown under both glasshouse and field conditions. Our results revealed a correspondence between profile changes detected at the molecular, biochemical and physiological level throughout the progression of leaf senescence measured at different plant developmental stages. Early metabolic changes were detected prior to anthesis and before the onset of the first senescence symptoms, with more pronounced changes observed when physiological and molecular variableswere assessed under field conditions. During leaf development, photosynthetic activity and cellgrowth processes decreased, whereas sucrose, fatty acid, nucleotide and amino acid metabolisms increased. Pathways related to nutrient recycling processes were also up-regulated. Members of the NAC, AP2-EREBP, HB, bZIP and MYB transcription factor families showed high expression levels, and their expression level was highly correlated, suggesting their involvementin sunflower senescence. The results of this study thus contribute to the elucidation of the molecular mechanisms involved in the onset and progression of leaf senescence in sunflower leaves as well as to the identification of candidate genes involved in this process.","palabras_clave":"DATA INTEGRATION|MICROARRAY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18659,"idioma_id":5,"titulo":"Neuquen, ciudad intermedia y nodo regional. Impacto reciente de los hidrocarburos de reservorios no tradicionales","resumen":"Se exponen en el presente trabajo, cuestiones teóricas, evidencias y reflexiones acerca de los cambios operados a lo largo de las últimas décadas en la ciudad de Neuquén, capital de la provincia argentina del mismo nombre y en las ciudades de su entorno, y los más recientes, producto del nuevo desarrollo de los hidrocarburos de reservorios no tradicionales.","palabras_clave":"NEUQUEN|URBANO|HIDROCARBUROS|NODOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18660,"idioma_id":5,"titulo":"Análisis Zooarqueológico del sitio Alero Dupuy (La Toma, San Luis). Tendencias tafonómicas y faunísticas","resumen":"En este trabajo se presentan los primeros resultados obtenidos de los análisis zooarqueológicos del sitio Alero Dupuy, provincia de San Luis. El sitio presenta un contexto arqueológico relacionado al Holoceno tardío y evidencias que sugieren la realización de actividades múltiples. Los datos obtenidos permiten discutir acerca de las tendencias de explotación faunística que pudieron haberse desarrollado a lo largo de la secuencia de ocupación del sitio.","palabras_clave":"ZOOARQUEOLOGÍA|SAN LUIS|SUBSISTENCIA|CAZADORES RECOLECTORES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18661,"idioma_id":4,"titulo":"Effect of the image detector response in the identification of low-level X-ray scattering signals from image subtraction","resumen":"This work is part of an investigation on the potential use of X-ray scattering patterns in diagnostic imaging. It is motivated by the interest of contrasting numerical simulations with experimental measurements of scattering patterns. The scatter image is obtained by means of a subtraction method, where the signal of interest corresponds to the difference between images measured with and without the presence of the scattering medium, using a collimated beam. The acquired image contains a wide range of signal intensities (high intensity in the transmission region and very low intensity in the scattering region) covering almost the whole dynamic range of the detector. This work aims to assess the effects of the signal transfer property (STP) of a digital detector on the scatter imaging derived from the subtraction method. The STP of a RadEye1 EV detector was measured showing a deviation from linearity particularly at low exposures. Therefore the STP was modeled by a piecewise quadratic-linear function. This model was applied to Monte Carlo simulated images that consider the interference effects in coherent scattering. Simulations were performed with the PENELOPE code. The loss in signal intensity due to the detector nonlinear response was in very good agreement with the scatter image measured using a mammographic X-ray tube and the characterized detector.","palabras_clave":"X-RAY SCATTERING PATTERN|SIGNAL TRANSFER PROPERTY|DIGITAL IMAGING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18662,"idioma_id":4,"titulo":"Episodic bamboo die-off, neighbourhood interactions, and tree seedling performance in a Patagonian mixed forest","resumen":"1.  Episodic mass flowering and subsequent die-off of bamboo understories may generate rare opportunities for tree regeneration by altering consumer-seedling interactions as much as by increasing light availability to seedlings. We hypothesized that bamboo dieback interacts with canopy neighbourhood composition in creating recruitment microsites for tree seedling species with varied shade tolerance and susceptibility to herbivory.     2.  We conducted a 2-year experiment in a Patagonian mixed forest altered by extensive, but patchy dieback of the bamboo Chusquea culeou. Newly emerged seedlings of Nothofagus alpina (more shade-tolerant) and N. dombeyi (less shade-tolerant) were planted in conspecific and heterospecific canopy neighbourhoods, with either a flowered (dead) or nonflowered (live) bamboo understorey. Seedlings were placed inside and outside mesh cages to assess mortality from vertebrate or invertebrate consumers.    3.  Vertebrate exclusion increased seedling survival regardless of bamboo condition. Seedling loss to invertebrates decreased with bamboo die-off, resulting in higher survival of N. alpina in dead than in live patches. In contrast, bamboo die-off increased N. dombeyi mortality by wilting, which counteracted the benefits of seedling release from consumers. Bamboo die-off increased light availability and enhanced seedling growth for both species.    4.  N. alpina seedlings were less damaged or killed by invertebrates under heterospecific canopies than under conspecifics (associational resistance), whereas N. dombeyi performance was unaffected by neighbourhood composition. Bamboo die-off did not change seedling performance patterns observed across canopy neighbourhoods with live bamboo understories.    5.  Synthesis. Gaps created by bamboo die-off can exert both positive and negative, species-specific effects on the likelihood of tree seedling establishment. We conclude that infrequent understorey disturbances coupled with canopy neighbourhood effects mediated by seedling consumers may drive gap-phase succession within old-growth forests.","palabras_clave":"associational effects, disturbance|herbivory, recruitment|population, community dynamics|understorey, recruitment, temperate forest"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18663,"idioma_id":5,"titulo":"Remoción de arsénico en localidades de la provincia de Santiago del Estero, Argentina. Evaluación del acceso, uso y calidad de agua en poblaciones rurales con problemas de arsénico","resumen":"Se realizó un trabajo sobre remoción de arsénico y provisiónde agua segura en localidades rurales de dos zonas dela provincia de Santiago del Estero, Argentina: una cercanaa la capital, en el Departamento Banda y otra al norte, en elDepartamento Copo. El trabajo estuvo a cargo de un grupotransdisciplinario formado por investigadores de las cienciasquímicas y las ciencias sociales. Un diagnóstico sobreacceso, usos y calidad de agua, que incluyó entrevistas enla población con respecto al acceso al agua segura, indicóque la zona al norte presentaba graves problemas en la calidaddel agua de consumo, agravados por difíciles condicionessocioeconómicas; mientras que en la zona de Banda, lasaguas no presentaron contaminación microbiológica ni altosniveles de arsénico. Se tomaron muestras de agua de las distintaspoblaciones y se caracterizaron fisicoquímicamente.En las que se consideró necesaria la remoción de arsénico,se evaluó la capacidad de algunos materiales económicoscon vías al diseño de dispositivos útiles para las poblacionesafectadas. En regiones similares podrían realizarse réplicasde este proyecto.","palabras_clave":"Arsénico|Remoción de Arsénico|Zonas Rurales|Tratamiento del Agua|Remoción de Contaminantes|Uso del Agua"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18664,"idioma_id":4,"titulo":"syntMaskFT: A Tool for Synthesizing Masking Fault-Tolerant Programs from Deontic Specifications","resumen":"In this paper we introduce syntMaskFT, a tool that synthesizes fault-tolerant programs from specifications written in a fragment of branching time logic with deontic operators, designed for specifying fault-tolerant systems. The tool focuses on producing masking tolerant programs, that is, programs that during a failure mask faults in such a way that they cannot be observed by the environment. It is based on an algorithm we have introduced in previous work, and shown to be sound and complete. syntMaskFT takes a specification and automatically determines whether a masking fault-tolerant component is realizable; in such a case, a description of the component is produced together with the maximal set of faults that can be supported for this level of tolerance. We present the ideas behind the tool by means of a simple example, and also report the result of experiments realized with more complex case studies.","palabras_clave":"Program Síntesis|Programa Verification|Formal MEthods"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18665,"idioma_id":4,"titulo":"Eucypris fontana (Graf, 1931) (Crustacea, Ostracoda) in permanent environments of Patagonia Argentina: a geometric morphometric approach","resumen":"Ostracods are microcrustaceans with a calcareous carapace, very useful as paleoenvironmental indicators. Eucypris fontana (Graf, 1931) is a non-marine ostracod species, distributed in southern Neotropics, commonly found in living bisexual populations as well as in quaternary sequences in Patagonia. Geometry morphometric analysis offers efficient and powerful techniques to quantify, describe and analyze shape and size variations. In this study, phenotypic changes in the carapace (size and shape) of E. fontana were analyzed using geometric morphometric methods. One hundred and two valves, including males and females from surface sediments of six permanent water bodies located in Patagonia, Argentina, were analyzed. Male and female valves are spread in the morphospace and sexual dimorphism in size and shape were no perceived. Valve size (centroid size) differed between environments; larger individual were correlated with higher Mg2+,Ca2+,K+ concentrations and temperature and lower pH (y9.1) of the host waters, whereas smaller specimens were associated with the opposite environmental extreme. The principal component analysis performed with Procrustes coordinates (shape) indicated a morphological gradient between elongated and rounded valves; major changes occurring on the dorsal margin, calcified inner lamella and in the position of the adductor muscles scars. Rounded carapaces were related whit higher Ca2+and Mg2+ concentration and lower pH (y8.6) environments, whereas elongated valves were associated with the opposite environmental extreme. These results highlight the importance of morphometric studies of E. fontana in ecological research and their potential use in paleoenvironmental studies in Patagonia and other regions where this taxon is found.","palabras_clave":"OSTRACODA|PATAGONIA|GEOMETRIC MORPHOMETRY|ENVIRONMENTAL CONTROL|PALEOENVIRONMENTAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18666,"idioma_id":5,"titulo":"Relación clima-vegetación: adaptaciones de la comunidad del jarillal al clima semiárido, Parque Nacional Lihué Calel, provincia de La Pampa, Argentina","resumen":"El estudio de la vegetación desde la Geografía se centra en el análisis de su distribución espacial y los factores que inciden en la misma. Uno de ellos es el clima que determina las características de las formaciones vegetales y, en una escala más grande, a las comunidades. El objetivo de este trabajo es analizar la relación clima-vegetación mediante el estudio de las adaptaciones de la comunidad del jarillal con respecto al clima semiárido en el Parque Nacional Lihué Calel, Argentina. Para ello se realiza el balance hídrico de Thornthwaite y Mather utilizando datos de la estación meteorológica del parque pertenecientes al periodo 1995-2010. Se aplican índices bioclimáticos y se realizan estands para conocer la composición florística y fisonomía de la vegetación. Se analizan las respuestas adaptativas identificadas en los individuos vegetales relevados y se comprueba que el clima semiárido condiciona la morfología y fisonomía del parque. Se demuestra la presencia de vegetación xerófila con predominio de arbustos y de cobertura abierta. Entre las adaptaciones observadas se distinguen la pérdida de hojas en la estación desfavorable, el reemplazo de hojas por espinas, hojas pequeñas y resinosas, inclinación de la hoja y raíces extensas.","palabras_clave":"JARILLAL|VEGETACIÓN XERÓFITA|ÍNDICES BIOCLIMÁTICOS|BALANCE HÍDRICO|ADAPTACIONES VEGETALES|PARQUE NACIONAL LIHUE CALEL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18667,"idioma_id":4,"titulo":"Dynamics of Normal and Reverse Polarization Switching in 1550nm-VCSELs under Single and Double Optical Injection","resumen":"Dynamics of Normal and Reverse Polarization Switching in 1550nm-VCSELs under Single and Double Optical Injection","palabras_clave":"VCSEL|Polarization Switching|Optical injection"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18668,"idioma_id":5,"titulo":"Análisis de la resistencia a la corrosión en lluvia ácida simulada de las aleaciones Zn-Sn","resumen":"El zinc y el estaño, junto con las aleaciones Zn-Sn, son empleados en la industria como recubrimientos del acero frente a la corrosión. Uno de sus usos más frecuentes es el galvanizado para exteriores, el cual es afec-tado por la corrosión debido a la lluvia ácida.   El objetivo del trabajo es evaluar el comportamiento electroquímico que presentan las aleaciones Zn-Sn, con respecto a los metales puros, en una solución acuosa de lluvia ácida simulada compuesta por 31,85 mg\/L H2SO4, 15,75 mg\/L HNO3, 21,25 mg\/L NaNO3, 46,20 mg\/L (NH4)2SO4, 31,95 mg\/L Na2SO4, 84,85 mg\/L NaCl, con un pH entre 3,5 y 4,0, a temperatura ambiente (25ºC). Para ello, se emplearon probetas de aleaciones con diferentes porcentajes en peso de estaño (6, 10 y 50), y de los metales puros, solidificadas horizontalmente.  Se tomaron muestras de cada estructura de grano revelada y se las desbastaron con papeles de SiC, de granulometría entre #60 y #1200. Posteriormente, se realizaron medidas de polarización potenciodinámica en una celda electroquímica convencional de tres electrodos y ensayos de inmersión. Cada probeta se examinó mediante microscopia óptica, antes y después de realizar los ensayos.   De las curvas potenciodinámicas se observó para los cortes transversales, que a medida que aumenta el con-tenido de estaño en la aleación, los potenciales tienden a valores más nobles. A partir de los ensayos de in-mersión se denotó que la estructura columnar de zinc y las aleaciones presentan una mayor pérdida de masa que las demás estructuras. Además, el zinc y las aleaciones presentaron la velocidad máxima de corrosión al primer día de inmersión, para todas las estructuras de grano. En las micrografías se evidenció que el zinc presentó corrosión generalizada.","palabras_clave":"Aleaciones Zn-Sn|Lluvia ácida|Corrosión"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18669,"idioma_id":5,"titulo":"PASIVIDAD EN SOLUCIÓN DE FOSFATO DE ACEROS INOXIDABLES SOLIDIFICADOS UNIDIRECCIONALMENTE","resumen":"La pasividad de los aceros inoxidables es atribuida a la formación de una película protectora, conformada por óxidos, sobre la superficie del metal. Esta película posee propiedades semiconductoras y está relacionada con múltiples factores que la hacen de importancia para la comprensión de los fenómenos de corrosión. En este trabajo se estudia la película pasiva formada en aceros inoxidables solidificados unidireccionalmente, Fe-18Cr-10Ni-2Mo-0,08C (muestra A), Fe-18Cr-14Ni-8Mo-0,03C (muestra C) y Fe-18Cr-10Ni-8Mo-0,08C (muestra F), para determinar la influencia de la variación de la estructura (equiaxial, columnar y con transición de columnar a equiaxial-TCE) en la resistencia a la corrosión, así como investigar la relación entre la resistencia a la corrosión y el espaciamiento dendrítico secundario del material. Para ello se emplean técnicas potenciodinámicas y galvanostáticas, análisis de MottSchottky y espectroscopía de impedancia electroquímica que se realizaron en solución de Na2HPO40,5 M (pH 9,2).Las curvas potenciodinámicas indican una región pasiva y un máximo de corriente en la región transpasiva. Las medidas galvanostáticas realizadas sobre películas pasivas formadas previamente indican dos amesetamientos de potencial, debido al óxido de Cr y óxido de Fe, del cual surgen dos tiempos de transición. El mayor espesor de óxido de hierro se encuentra en las estructuras equiaxial de la muestra F, que posee el menor espaciamiento dendrítico respecto de los otras dos muestras teniendo en cuenta la misma estructura. El análisis de Mott Schottky muestra que la película pasiva se comporta como un semiconductor tipo n en el rango de potenciales de -0,45 V a 0 V, con una densidad de donores que varía de acuerdo a la composición del acero inoxidable. También se observa que la densidad de donores varía de acuerdo al tipo de estructura para un mismo material.","palabras_clave":"aceros inoxidables|películas pasivas|Mott Schottky|resistencia a la corrosión"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18670,"idioma_id":5,"titulo":"Factores de riesgo asociados a la aparición del linfedema en las pacientes mastectomizadas atendidas en el Servicio de Oncología del Hospital Julio C. Perrando entre los años 2011 y 2012","resumen":"Se realizó una investigación cuantitativa, analítica de casos y controles, retrospectiva, transversal y observacional que tuvo como objetivo establecer la relación entre grupo etario, nivel de instrucción, tipo de cirugía, número de ganglios extirpados y la aparición del linfedema dentro del año posterior a la cirugía en pacientes mastectomizadas.  Las unidades de análisis fueron pacientes mastectomizadas atendidas en el Servicio de Oncología del Hospital Julio C. Perrando de la Ciudad de Resistencia Chaco, entre 2011 y 2012.   Los resultados mostraron que las pacientes mastectomizadas del grupo etario de 51 a 65 años tuvieron 1,22 veces más probabilidades de presentar linfedema; luego del año posterior a la cirugía.  En cuanto al nivel de instrucción incompleto se asoció a la aparición del linfedema, presentándose como un factor de protección con un OR de 0,17 siendo estadísticamente significativo.  Respecto al tipo de cirugía realizada, se constató que las pacientes que recibieron mastectomía radical obtuvieron un OR de 1,90 representó un factor de riesgo este tipo de cirugía, en cambio las pacientes intervenidas quirúrgicamente con extirpación de más de 5 ganglios obtuvieron un OR de 2,5 presentándose como factor de riesgo para padecer linfedema.","palabras_clave":"CANCER|MAMA|LINFEDEMA|MASTECTOMIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18671,"idioma_id":5,"titulo":"El doble vínculo entre representaciones sociales y comunicación social","resumen":"Este trabajo desarrolla una reflexión teórica cuyo objetivo es elaborar una articulación entre el enfoque de las representaciones sociales propuesto por Serge Moscovici y el fenómeno de la comunicación social. Para este fin, se plantea y analiza la tesis del doble vínculo entre las representaciones sociales [RS] y la comunicación social [CS]. La exploración teórica de esta tesis permite, por un lado, problematizar el rol de las RS en los procesos de comunicación e interacción social; y por el otro, contribuir a elucidar el modo en que las RS se construyen, conservan y transforman a través de procesos comunicacionales de construcción social de sentido.","palabras_clave":"COMUNICACIÓN|SOCIEDAD|PROCESO DE COMUNICACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18672,"idioma_id":4,"titulo":"A survey on occurrence of Cladosporium fulvum identifies race 0 and race 2 in Tomato growing areas of Argentina","resumen":"The presence of Cladosporium fulvum (syn. Passalora fulva), causal agent of tomato leaf mold, was confirmed in the two main greenhouseproduction areas for tomato in Argentina. Using both morphological characters and internal transcribed spacer sequencing, we confirmed the presence of physiological races of this pathogen. A diagnostic multiplex polymerase chain reaction (PCR) was also developed, using primers derived from C. fulvum avirulence (Avr) genes. In all, 20 isolates of Cladosporium spp. were obtained as monospore cultures and 12 were identified as C. fulvum. By this method, we showed that, of these 12 isolates, 5 were race 0 (carrying functional Avr2, Avr4, Avr4E, and Avr9 genes) and 7 were race 2 (lacking the Avr2 gene). Race identity was confirmed by testing their virulence on a set of tomato differentials carrying different Cf resistance genes. All Avr genes could be amplified in single or multiplex PCR using DNA isolated from in vitro grown monospore cultures but only three Avr could be amplified when genomic DNA was isolated from C. fulvum-infected necrotic leaf tissue.","palabras_clave":"Passalora fulva|avr genes|races"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18673,"idioma_id":5,"titulo":"Múltiples líneas de evidencias aplicadas al estudio de un individuo prehispánico. Sitio Rancho José (Buenos Aires).","resumen":"En este trabajo presentamos la información osteológica, cronológica, isotópica y de ADNa obtenida a partir del análisis de los restos óseos humanos fragmentados correspondientes a un individuo prehispánico recuperado en el sitio Rancho José. Dicho sitio está ubicado en la margen derecha del río Baradero, donde la acción del agua expuso y removió diferentes tipos de materiales arqueológicos. De acuerdo con la excavación realizada en seis perfiles ubicados en el borde de la barranca, se pudo determinar que los hallazgos fueron depositados en un evento de ocupación. En el perfil 5 se recuperaron los restos óseos de un individuo datado entre 1900 ±20 AP representado solo por la porción superior del esqueleto. En primer lugar, se consideraron los agentes tafonómicos que podrían haber actuado modificando las condiciones de hallazgo y los materiales asociados. Respecto de los restos óseos se realizó la determinación del sexo y estimación de edad del individuo y se examinaron las diferentes patologías óseas y dentales. Esta información se complementó con datos obtenidos a partir del análisis de ADNmt antiguo, de isótopos estables (&#948;13C, &#948;15N y &#948;18O) y el relevamiento de micro-restos vegetales en el tártaro dental. Si bien se trata de un individuo altamente fragmentado conserva su aparato masticatorio completo y su estudio resulta de interés para comparar con otros individuos, tanto de sitios coetáneos como de tiempos poshispánicos. En tal sentido también se presentan datos isotópicos de dos individuos del sitio poshispánico Cementerio Indígena.","palabras_clave":"Bioarqueología|tafonomía|ADNmt|isótopos estables"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18674,"idioma_id":5,"titulo":"RESTOS ÓSEOS HUMANOS FRAGMENTADOS DEL CEMENTERIO  INDÍGENA DE BARADERO. ALCANCES Y LIMITACIONES  DE SU ESTUDIO BIOARQUEOLÓGICO","resumen":"Se analizan los restos óseos humanos fragmentados correspondientes al sitio ?Cementerio Indígena?, ubicado en Baradero, Pcia. de Buenos Aires. Según las características de los materiales asociados a los enterratorios, se atribuyó una cronología correspondiente a la primera mitad del siglo XVII; esta estimación temporal ha sido corroborada actualmente mediante dos fechados radiocarbónicos. El registro arqueológico se ha vinculado con  la misión franciscana ?Santiago del Baradero? que fundó Hernandarias en 1615. Entre los objetivos que se persiguen con este estudio se destacan: la revalorización de la información bioarqueológica que proporcionan los restos óseos fragmentados con características similares a las de un osario; y la relevancia que adquiere este registro dado que es único en su tipo y puede aportar conocimientos sobre el impacto de la empresa evangelizadora colonial en el área. Si bien el estudio bioarqueológico está limitado por la falta de integridad de las piezas esqueletales, rescatamos información sobre el número mínimo de individuos, edad, sexo, posibles patologías e indicadores de actividad más frecuentes. Asimismo, evaluamos indicadores de estrés nutricional y dieta mediante el análisis dentario, ponderando un número mínimo de 19 individuos. Discutimos su relación con el contexto sociocultural y los posibles cambios producidos por el conflicto interétnico.","palabras_clave":"osario|reducción indígena |Bioarqueología |Arqueología histórica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18676,"idioma_id":4,"titulo":"The influence of effortful control and empathy on perception of school climate","resumen":"The purpose of this study was to determine the predictive power of effortful control (EC) and empathy for perception of school climate. Self-report measures of EC, dispositional empathy, and perception of school climate were obtained for 398 students (204 females) aged 12 to 13.  Sociometric status was peer-evaluated, and academic achievement was based on students´ final grades at the end of the school year. The structural equation model that was developed confirms the influence of EC and empathy on perception of school climate.  The model manages to explain 39% of the variance in perception of school climate, and confirms that for males and females alike the predictive power of EC and empathy is greater than for other variables studied such as academic achievement and sociometric status. Further, EC and empathy are found to have a positive influence on academic achievement. The importance of developing activities to foster EC and empathy in order to facilitate interpersonal relationships and enhance perception of the school climate is discussed.","palabras_clave":"effortful control|executive functions|climate perception"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18677,"idioma_id":4,"titulo":"Analyzing the Hydrodynamic and Crowding Evolution of Aqueous  Hydroxyapatite-Gelatin Networks: Digging Deeper into Bone Scaffold Design Variables","resumen":"The hydration of the polypeptide network is a determinant factor to be controlled on behalf of the design of precise functional tissue scaffolding. Here we present an exhaustive study of the hydrodynamic and crowding evolution of aqueous gelatin-hydroxyapatite systems with the aim of increasing the knowledge about the biomimesis of collagen mineralization; and how it can be manipulated for the preparation of collagenous derived frameworks with specific morphological characteristics. The solution´s density and viscosity evaluation measurements in combination with spectroscopic techniques revealed that there is a progressive association of protein chain that can be influenced by the amount of hydroxyapatite nanorods. Gelatin and additives? concentration effect on the morphology of the gelatin scaffolds was investigated. Transverse and longitudinal sections of the obtained scaffolds were taken and analyzed using optical microscopy. It can be seen that the porous size and shape of gelatin assemblies can be easily adjusted by controlling the gelatin\/HAp ratio in the solution used as template in agreement with our statement.","palabras_clave":"GELATIN|HYDROXYAPATITE|SCAFFOLDS|INTRINSIC-VISCOSITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18678,"idioma_id":4,"titulo":"Application of compost to different texture soils: Effect on soil properties and productivity of lettuce crop","resumen":"Application of Compost to Different Texture Soils: Effect on SoilProperties and Productivity of Lettuce CropA.M. Miglierinaa, J.O. Iglesias, G.C. Laurent, R.A. Rodriguez, M.E. Ayastuy andJ.C. LobartiniAgronomy Department, Universidad Nacional del SurAv. San Andres 800(8000) Bahía BlancaArgentinaKeywords: compost; soil properties, nutrient uptake, lettuceAbstractThe application of composted organic wastes to soil can be used for conservingsoil organic matter, reclaiming degraded soils and supplying plants with nutrients. Twogreenhouse experiments were carried out to evaluate the addition of compost onchemical and physical properties of soils. Four different texture soils were used: Sandysoil (S1), Silty loam soil (S2), Clay loam soil (S3) (33.2 O.C. g.kg-1) and Clay loam soil(S4) (14.8 O.C. g.kg-1) cultivated with lettuce (Lactuca sativa L.) in the Bahía Blancaregion, Argentina.The application of compost had a significant effect on lettuce productivity andnutrient uptake by the crop in three of the four soil types; showing a positive effect onthe dry weight, number, length and width of the leaves. The applied dose (40 Mg ha-1)modified the chemical composition of the plants: those grown in soil with addedcompost showed higher concentrations of nutrients than those grown in control soils. Inclay loam soil (S3) no difference were found in plant productivity between treatmentswith and without application of compost.With respect to soil properties changes, the application of compost affected thesoil pH in variable way; increased organic carbon, total nitrogen and availablephosphorus. The addition of compost lowered bulk density in soils S2 and S4; increasedthe percentage of macropores and mesopores in S2; diminished content of mesoporesand increased content of micropores at S3 and S4. The variations on chemical andphysical soil properties demonstrate the benefits of compost addition, even in a shortperiod of time.","palabras_clave":"COMPOST|AMENDMENTS|LACTUCA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18679,"idioma_id":4,"titulo":"Electronic structure and magnetism on FeSiAl alloy: A DFT study","resumen":"Density functional theory (DFT) calculation has been performed to study the electronic structure and chemical  bonding in FeSiAl alloy. These calculations are useful to understand the magnetic properties of this alloy. Our results show that the mean magnetic moment of Fe atoms decreases due to the crystal structure and the effect of Si and Al. Depending on the environment, the magnetic moment of one Fe site (Fe1) increases to about 14.3% while of the other site(Fe2) decreases to about 25.9% (compared with pure bcc Fe). All metal-metal overlap interactions are bonding and slightly weaker than those found in the bccFe structure. The electronic structure (DOS) shows an important hybridization among Fe, Si and Al atoms, thus making asymmetric the PDOS with a very slight polarization of Al and Si atoms. Our study explains the importance of crystal structure in determining the magnetic properties of the alloys. FeSiAl is a good candidate for electromagnetic interference shielding combining low price and good mechanical and magnetic properties.","palabras_clave":"Fe-Si-Al ALLOY|DFT|SOFT MAGNETICAL PROPERTIES|MAGNETICAL MATERIALS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18680,"idioma_id":5,"titulo":"Modelización de una prueba de Afecto hacia la Matemática con la Teoría de Respuesta al Ítem","resumen":"Se aplicó el Modelo de Crédito Parcial (MCP) de la Teoría de Respuesta al Ítem (TRI) al análisis de ítems de una escala que mide Afecto hacia la Matemática. Esta variable describe el interés de los estudiantes de Psicología por involucrarse en actividades vinculadas a la matemática y los sentimientos asociados al uso de sus conceptos. La prueba consta de 8 ítems con formato de respuesta Likert de 6 opciones. Participaron 1875 estudiantes de Psicología de la Universidad de Buenos Aires (Argentina) de los cuales un 82% fueron mujeres. El análisis de la consistencia interna brindó un índice altamente satisfactorio (Alfa = .91). Se verificó la condición de unidimensionalidad requerida por el modelo mediante un análisis factorial exploratorio. Todos los análisis basados sobre la TRI se realizaron con el programa Winsteps. La estimación de los parámetros del modelo se efectuó por Máxima Verosimilitud Conjunta. El ajuste del MCP fue satisfactorio para todos los ítems. La Función de Información del Test fue elevada en un rango amplio de niveles del rasgo latente. Un ítem presentó una inversión en dos parámetros de umbral. Como consecuencia, 1 de las 6 categorías del ítem no fue máximamente probable en ningún intervalo de la escala del rasgo latente. Se analizan las implicancias de este hallazgo en la evaluación de la calidad psicométrica del ítem. Los resultados de este estudio permitieron profundizar el análisis del constructo y aportaron evidencias de validez basadas en las estructura interna de la escala.","palabras_clave":"EDUCACIÓN MATEMÁTICA|ACTITUD HACIA LA MATEMÁTICA|DOMINIO AFECTIVO|MODELO DE CRÉDITO PARCIAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18681,"idioma_id":5,"titulo":"Variabilidad fenotipica observada en clones de banana (Subgrupo: Cavendish)  en el Nordeste Argentino","resumen":"Se analizaron  caracteres de morfología externa en poblaciones de banano de las localidades de Laguna Naikneck, Clorinda, Laguna Blanca, Riacho He He y Laguna Yema en la Provincia de Formosa (Argentina). Se aplicaron análisis de varianzas individuales, discriminante y de correlación utilizando el  software InfoStat versión 2004. La matriz de correlaciones fenotípicas  obtuvo dos componentes principales que determinaron variabilidades intra individuales del 60.42%. Los rasgos de mayor importancia para la discriminación de las poblaciones fueron altura del hijo; número de manos; ancho de la hoja; longitud del pecíolo;  diámetro y longitud del dedo central de la 2ª mano; diámetro y longitud de la última mano. El análisis de correlación detectó una correlación perfecta  entre altura del pseudotallo con las temperaturas máximas y mínimas mensuales. El objetivo fue analizar la variabilidad fenotípica existente en las poblaciones e identificar las características más importantes para la selección de clones sobresalientes.","palabras_clave":"VARIABILIDAD|FENOTIPICA|CLONES |BANANA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18682,"idioma_id":5,"titulo":"Zoonosis Parasitarias EMERGENTES","resumen":"El proyecto sedesarrolla desde 2005 en los barrios Piria, El Zanjón, Villa Rubencito y ElMolino de Ensenada. Objetivo: Bajoel concepto ?un mundo\/una salud? se realiza vigilancia epidemiológica dediversas parasitosis zoonóticas. En el marcode Jornadas Educativo-saludables, mensuales, se realizan talleres dirigidos aalumnos y la comunidad, con recolección de datos epidemiológicos. Se investiganheces, sangre, orina y piel de caninos, felinos y porcinos (animales centinela).Muestras de heces, orina y sangre humanas son recolectadas. Atención primaria,ecografías renales y cardíacas, inmunización antirrábica, desparasitación y controlde natalidad de caninos y felinos mediante esterilizaciones. Toma de muestrasde suelo y bentos investigando la presencia formas de diseminación\/infecciónparasitarias.Enteroparasitosis:64,8% (humanos), 73,3% (caninos), Dioctofimosis canina: 48,75%; Ectoparasitosispotencialmente zoonóticas: 70%, casos aislados de Dirofilariosis. en caninos.El suelo también se halló contaminado con huevos de D. renale (63,3%), Capillariasp., Toxocara sp., Trichuris sp., Strongylidos y nematodosde vida libre.Suelo,animales y humanos del lugar están altamente parasitados, los resultadosobtenidos indican la necesidad de investigar otras enfermedades que puedenestar presentes en el lugar, dado el hallazgo de los invertebradostransmisores. Dada la elevadaprevalencia de D. renale, T. canis, T. cati y A. suum encaninos, felinos y cerdos respectivamente (bioindicadores) y de Uncinarias enhumanos, se comenzarán a elaborar y utilizar nuevas herramientas para eldiagnóstico e inmunización a partir de antígenos de excresión-secresión y proteínasparasitarias en colaboración con los Institutos C. Malbrán e INIBIOLP.","palabras_clave":"Zoonosis|Emergentes|Parásitos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18683,"idioma_id":5,"titulo":"¿Quién es el dueño de los átomos? Nanotecnologías y derecho de propiedad intelectual","resumen":"En América Latina, bajo la premisa de una mejor competitividad, han aumentado exponencialmente los recursos dirigidos al desarrollo de las nanotecnologías. En este marco, las discusiones en torno a la aplicación de derechos de propiedad intelectual en nanotecnologías ocupan un lugar central. Al margen de la preocupación expresada tanto en ámbitos públicos como privados, resulta escasa la producción académica referida a dichos derechos en esta área. De ahí que este trabajo se proponga problematizar acerca de la aplicación de los derechos de propiedad intelectual en el desarrollo de nanotecnologías, mediante la selección y revisión crítica de la literatura disponible. Del análisis se desprende la existencia de una controversia en torno a las restricciones que impone la aplicación de patentes al uso de productos de ?primera generación?, lo que enfrenta, por un lado, a quienes reclaman derechos a retribución por regalías en I+D y, por otro, a quienes plantean el acceso libre al conocimiento científico-técnico.","palabras_clave":"nanotecnologías|propiedad intelectual|patentes|OMC|políticas científicas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18684,"idioma_id":4,"titulo":"One kilometre-thick ultramylonite, Sierra de Quilmes, Sierras Pampeanas, NW Argentina","resumen":"We describe a 1km-thick ultramylonite forming the high strain base of the >3.5 km thick El Pichao shear zone in the Sierra de Quilmes. This shear zone thrusted granulite facies migmatites onto amphibolite facies rocks during the 470 Ma Famatinian orogeny. Strain grades upwards from ultramylonites to weakly sheared migmatites across the 3.5 km zone and the mylonitic rocks define a geochemical field narrower than the protolith suggesting they underwent mixing and homogenization through shearing. Ultramylonites this thick are uncommon. The width of a shear zone, in the absence of significant compositional rheological contrasts controlling strain localization, is controlled by the balance between shear heat generation and diffusion. Under typical crustal conditions a strain rate of 10-12s-1 is required to form a 1 km-thick ultramylonite, and this is achieved when large movement velocities are imposed across the shear zone. We postulate that the El Pichao shear zone and its thick ultramylonite accommodated a significant fraction of convergence velocities driving the orogeny, and that the wide mylonitic shear zones characteristic of the Cambrian-Ordovician deformation of the Sierras Pampeanas result from the convergent movement being taken up by only a few active major shear zones.     One kilometre-thick ultramylonite, Sierra de Quilmes, Sierras Pampeanas, NW Argentina.","palabras_clave":"MILONITAS|ULTRAMILONITAS|DEFORMACION|NOROESTE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18685,"idioma_id":4,"titulo":"Susceptibility of preparasitic stages of Chordodes nobilii (Gordiida, Nematomorpha) to the fungicide Carbendazim","resumen":"We evaluated the effect of carbendazim on non-target organisms using the parasite Chordodes nobilii as a test organism. The Gordiida act as a link between freshwater and terrestrial ecosystems; and C. nobilii, a neotropical representative species of this group, has been shown to be sensitive to other contaminants even at environmentally acceptable concentrations. The taxa susceptible to carbendazim, however, may not be adequately represented among the standard aquatic test species used in ecotoxicological risk assessment. Moreover, the autochthonous organisms in this area that could be used as bioindicators still need to be found. The aim of the present work was therefore to assess the susceptibility of the preparasitic stages of C. nobilii to noxious effects by carbendazim. The assay protocol consisted in 96- and 48-h acute exposures of early embryonic stages and larvae, respectively, to concentrations ranging from 10 to 360 &#956;g\/l. Embryonic development was not inhibited by carbendazim at any of the evaluated concentrations, but the infectivity of larvae emerging from the exposed eggs was significantly diminished. Larval survival rate was also affected at the lowest concentration assayed. Values of the mean inhibition concentration (IC50) were 7 and 11 &#956;g\/l for embryos and larvae, respectively. Compared to other freshwater organisms, C. nobilii can be considered a species moderately to highly susceptible to carbendazim. As the expected environmental concentrations of carbendazim range from 6.25 to 41.3 &#956;g\/l, C. nobilii could well be a species in danger when exposed to this fungicide.","palabras_clave":"Chordodes nobilii|Carbenazim|Bioassay"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18686,"idioma_id":4,"titulo":"Effect of temperature on life history traits during immature development of Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae) from Cordoba city, Argentina","resumen":"We investigated how ambient temperature under &#64258;uctuating conditions affects the larval?pupal immature traits of Aedes aegypti and Culex quinquefasciatus mosquitoes from Córdoba city, Argentina, and established each species development threshold and physiological time. Based on life tables, three cohorts of each mosquito species were reared in the laboratory under small &#64258;uctuating temperatures conditions of 15.2 ± 1.7 &#9702;C, 17.9 ± 1.6&#9702;C, 21.6 ± 0.7&#9702;C and 25.3 ± 0.4&#9702;C for Ae. aegypti, and 16.6 ± 1.7C and 25.2 ± 0.3C for Cx. quinquefasciatus. Immature development time and survival values, and also thermal development threshold and physiological time were estimated. Development times of all larval and pupal stages of Ae. aegypti and Cx. quinquefasciatus were signi&#64257;cantly affected by the rearing temperatures, decreasing when temperature increased. Mean Ae. aegypti total (larva + pupa) development timeranged from 21.9 to 8.6 days, at 15.2 and 25.3 &#9702;C, whereas, for Cx. quinquefasciatus varied between 23.5 to 9.2 days at 16.6 and 25.2&#9702;C, respectively. Larval and pupal survival of both species was affected bydifferent rearing temperatures, increasing in general as temperature increased. For Ae. aegypti the total immature survival ranged from 26% at 15.2&#9702;C to 92% at 21.6C; however, temperature did not have signi&#64257;cant effect on this variable. The total immature survival of Cx. quinquefasciatus was signi&#64257;cantly and positively affected by temperatures, ranging from 32 to 88%, at 16.6 and 25.2&#9702;C. The temperature development threshold and the physiological time estimated for Ae. aegypti and Cx. quinquefasciatus were 11.11&#9702;C and 93.74 degree-days, and 10.96C and 136.87 degree-days, respectively. The results of the present study showed that temperature signi&#64257;cantly affects the larval?pupal immature traits of these mosquito species of sanitary importance, from the central region of Argentina. All the parameters recorded are useful for the development of mosquito management models. &#9702;&#9702;&#9702;C, 18.7 ± 1.7&#9702;","palabras_clave":"CULICIDAE|IMMATURE|DEVELOPMENT|TEMPERATURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18687,"idioma_id":4,"titulo":"Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors","resumen":"Cases of human visceral leishmaniasis (HVL) were not recorded until recently in the Chaco region of northwestern Argentina. Dogs were surveyed at the sites of infection of two HVL index cases in the Chaco region of Salta province. Canine cases (CanL) were diagnosed by two parasitological methods, two molecular methods targeting mini- and maxicircle DNA, and immunochromatographic dipstick. Among 77 dogs studied, 10 (13%) were found infected with Leishmania spp. In seven dogs and two humans, the infecting species was typed as Leishmania (Leishmania) infantum. The same genotype was detected in the human and two of the CanL. Although several diagnostic methods displayed weak or moderate agreement, the concordance values for serology versus maxicircle PCR were very good (Kappa index = 0.84). Sandflies captured in the area were identified as Lutzomyia migonei and Lu. cortelezzii\/Lu. sallesi (cortelezzii complex). The focal appearance of leishmaniasis in dogs and humans in a sylvatic region and its relatively low prevalence of infection suggests that L. (L.) infantum transmission to dogs and humans may, in this region, stem from sylvatic reservoirs.","palabras_clave":"LEISHMANIASIS|RESERVORIOS|LUTZOMYIA|SALTA-ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18688,"idioma_id":5,"titulo":"Procesamiento numérico. Relaciones con el desempeño en matemática en niños","resumen":"El procesamiento numérico es la habilidad para representar y manipular numerosidades, ya sea en un formato simbólico (procesamiento numérico simbólico) o analógico (procesamiento numérico no simbólico). La literatura muestra resultados contradictorios respecto de la relación de esta capacidad con el desempeño general en matemáticas en niños. La comprensión de ésta es relevante para el diseño de instrumentos de screening e intervenciones en niños con dificultades en el aprendizaje de las matemáticas. Objetivo: El objetivo de este trabajo fue realizar una revisión de la literatura que esclarezca los resultados contradictorios entre estudios. Método: se realizó una búsqueda sistemática en las bases de EBSCO y PubMed utilizando diferentes combinaciones de los términos en español y en inglés: procesamiento numérico (numerical processing), matemática (mathematics), desempeño académico (academic achievement), niños (children) Resultados: los trabajos revisados indican que el mapeo entre los sistemas de procesamiento numérico simbólicos y no simbólicos predice el desempeño en matemáticas. Por otra parte, el valor predictor de la capacidad de procesamiento numérico no simbólico sobre el desempeño en matemática no sería constante a lo largo del desarrollo y podría variar conforme al estatus socio-económico de los sujetos. Conclusiones: se discuten algunos aspectos metodológicos que permitirían profundizar la comprensión de la relación entre el procesamiento numérico y el desempeño general en matemática.","palabras_clave":"procesamiento numérico|matemática|niños"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18689,"idioma_id":5,"titulo":"Fertilización fosfatada en trigo en la zona semiárida: Su influencia sobre el rendimiento y la eficiencia en el uso del N y del agua.","resumen":"Dentro de la zona semiárida, el trigo es el cultivo que ocupa la mayor superficie en el sudoeste de la provincia de Buenos Aires. Un factor clave en los sistemas productivos de esta zona es el manejo del recurso agua, primer limitante de los rendimientos, seguido por el fósforo y el nitrógeno (según el sitio). Por ello se evaluó la respuesta a la fertilización con fósforo y su influencia sobre la nutrición del cultivo y la eficiencia en el uso del agua.","palabras_clave":"fósforo|nutrición"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18690,"idioma_id":4,"titulo":"Electrochemical production of colloidal sulphur by reduction of sulphur dioxide using a parallel plate reactor with convergent flow","resumen":"A   parallel-plate electrochemical  reactor with a double convergent flow at   the cathodic and also at the anodic  compartment is analysed for the   production of colloidal sulphur by reduction of  sulphur dioxide. A   reactor with convergent flow was adopted in order to enhance  the   mass-transfer conditions along the electrode length. A mathematical    treatment is presented for reactors with convergent flow based on the   plug flow  model, which can predict the maximum current. However, at   higher times the  cathode is blocked by the deposited sulphur decreasing   the current. The best  working conditions were achieved with a    polished cathode working at a potential of -0.7 V against SCE for a   volumetric flow rate of 8.33 x 10-6   m3   s-1   obtaining  19.6 kg m-3   h-1     as  the maximum value of space time yield, for which the electrical   parameters were  2.6 V average cell voltage, 22 kWh kg-1    specific   energy consumption and 40 % current efficiency. The colloidal  sulphur   presents particles of spheroidal shape with an average diameter of 1.85 &#956;m.","palabras_clave":"COLLOIDAL SULPHUR|SULPHUR DIOXIDE|CONVERGENT FLOW|ELECTROCHEMICAL REACTOR|SULPHUR PRODUCTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18691,"idioma_id":5,"titulo":"DIAGNÓSTICO DE FERTILIDAD NITROGENADA EN TRIGO MEDIANTE EL USO DE UN CLOROFILÓMETRO EN EL SUDOESTE BONAERENSE","resumen":"El cultivo de trigo es la base de los sistemas productivos en un amplio sector del Sudoeste bonaerense (SOB). Sus rendimientos están son influenciados por las condiciones climáticas y las propiedades edáficas, obligando a un uso eficiente del agua y del nitrógeno (N) (Galantini et al., 2004). El N es un elemento indispensable para maximizar el rendimiento y la calidad de los cultivos, constituyendo uno de los principales factores limitantes de la productividad del trigo (Triticum aestivum L.) en la región. Por su dinámica, susceptibilidad a las pérdidas y altos requerimientos de las plantas, es de gran importancia realizar un manejo eficiente de este nutriente, a fin de efectuar recomendaciones ajustadas a la fertilización que optimicen la nutrición nitrogenada del cultivo (Ferrari et al., 2011). En las regiones, semi-áridas y sub-húmedas, la optimización de la aplicación de fertilizantes es difícil, debido a la errática disponibilidad de agua de las precipitaciones (Galantini et al., 2000; Cantero-Martínez et al., 2003).","palabras_clave":"Indice de Verdor|ACA 303|Región suibhúmeda"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18692,"idioma_id":5,"titulo":"MINERALIZACIÓN DE NITRÓGENO EN SUELOS DEL SUDOESTE BONAERENSE","resumen":"El Sudoeste (SO) bonaerense se caracteriza por la erraticidad en las precipitaciones, con un promedio anual que oscila entre 500 a 700 mm, con gran variabilidad de ocurrencia y dos picos anuales tanto en el otoño como en la primavera. Debido a estas características climáticas, en las regiones semiáridas y subhúmedas, la optimización de la aplicación de fertilizantes es difícil. En estos casos, adecuar las aplicaciones a las condiciones de fertilidad particulares y al potencial de rendimiento esperado permitiría optimizar la fertilización. Estimaciones de la recuperación del nitrógeno (N) aplicado a nivel mundial como a nivel de parcelas concuerdan en valores entre el 30 y 50%. Es decir, se utiliza una pequeña parte del N que se aplica, con un gran costo económico y ambiental. Para mejorar la eficiencia se debe conocer cómo los diferentes factores ligados a la producción la modifican y de esta forma plantear estrategias tendientes a maximizarla. El diagnóstico de la necesidad de fertilizante nitrogenado del cultivo debería contemplar tanto la disponibilidad de N mineral en el suelo al momento de la siembra como el que se mineralizaría durante la estación de crecimiento del cultivo.","palabras_clave":"MINERALIZACIÓN|REGIÓN SEMIÁRIDA|ÍNDICES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18693,"idioma_id":4,"titulo":"Eocene primates of South America and the African origins of New World monkeys","resumen":"The platyrrhine primates, or New World monkeys, are immigrantmammals whose fossil record comes from Tertiary and Quaternarysediments of South America and the Caribbean Greater Antilles1,2.The time and place of platyrrhine origins are some of the most controversialissues in primate palaeontology, although an AfricanPalaeogene ancestry has been presumed by most primatologists3,4.Until now, the oldest fossil records of New World monkeys havecome from Salla, Bolivia5,6, and date to approximately 26 millionyears ago, or the Late Oligocene epoch. Here we report the discoveryof newprimates fromthe ?Late Eocene epoch ofAmazonianPeru,which extends the fossil record of primates in South America backapproximately 10 million years. The new specimens are importantfor understanding the origin and early evolution of modern platyrrhineprimates because they bear little resemblance to any extinctor living South American primate, but they do bear striking resemblancesto Eocene African anthropoids, and our phylogenetic analysissuggests a relationship with African taxa. The discovery of thesenew primates brings the first appearance datum of caviomorph rodentsandprimates in SouthAmerica back into close correspondence,but raises new questions about the timing and means of arrival ofthese two mammalian groups.","palabras_clave":"Eocene|Primates|Peru|Platyrrhini"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18694,"idioma_id":5,"titulo":"Contomastix serrana (Cei & Martori, 1991). Primer registro  para la provincia del Chaco (República Argentina)","resumen":"Los registros de distribución de Contomastix  serrana son principalmente en las sierras  de las provincias de Córdoba, San Luis y Santiago  del Estero (Cei y Martori, 1991; Cei, 1993; Pérez et  al., 2004; Avila et al., 2013). Sin embargo, la única  población hallada en un área protegida es la que se  encuentra en la llanura chaqueña en el Parque Nacional  Copo, en la provincia de Santiago del Estero  (Arias y Lobo, 2005). Así como en otras especies del  género, tales como C. leachei y C. vittata, se conoce  muy poco sobre el rango de distribución de C. serrana  (Fig. 1). Una de las posibles causas de esto es  que estas especies son de hábitos sigilosos, viviendo  bajo las rocas cerca de arroyos (Arias et al., 2013).  En la presente nota se da a conocer el hallazgo de  Contomastix serrana (Fig. 2) para el Parque Natural  Provincial Fuerte Esperanza, siendo este el primer  registro para la provincia del Chaco, extendiéndose  60 km al norte la distribución de esta especie. El  ejemplar fue encontrado activo a las 16:30 hs. entre  ramas caídas, en el interior de un bosque degradado  de quebracho colorado santiagueño (Schinopsis  lorentzii) y quebracho blanco (Aspidosperma  quebracho-blanco) típico del Distrito Chaqueño  Occidental de la Provincia Fitogeográfica Chaqueña  (Cabrera, 1976).","palabras_clave":"Contomastix|Chaco|teidos|lagarto"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18695,"idioma_id":4,"titulo":"Climate-driven terrestrial inputs in ultraoligotrophic mountain streams of Andean Patagonia revealed through chromophoric and fluorescent dissolved organic matter","resumen":"Fluvial networks transport a substantial fraction of the terrestrial production, contributing to the global carboncycle and being shaped by hydrologic, natural and anthropogenic factors. In this investigation, four Andean Patagonian oligotrophic streams connecting a forested catchment (~125 km2) and draining to a double-basin large and deep lake (Lake Moreno complex, Northwestern Patagonia), were surveyed to analyze the dynamics of the allochthonous subsidy. The results of a 30 month survey showed that the catchment supplies nutrients and dissolved organic matter (DOM) to the streams. The eruption of the Puyehue?Cordón Caulle at the beginning of the study overlapped with seasonal precipitation events. The largest terrestrial input was timed with precipitation which increased particulate materials, nutrients and DOM through enhanced runoff. Baseline suspended solids and nutrients were very low in all the streams (suspended solids: ~1 mg\/L; total nitrogen: ~0.02 mg\/L;total phosphorus: ~5 &#956;g\/L), increasing several fold with runoff. Baseline dissolved organic carbon concentrations (DOC) ranged between 0.15 and 1 mg\/L peaking up to three-fold. Chromophoric and fluorescent analyses characterized the DOM as of large molecular weight and high aromaticity. Parallel factor modeling (PARAFAC) of DOM fluorescence matrices revealed three components of terrestrial origin, with certain degree of microbial processing: C1 and C2 (terrestrial humic-like compounds) and C3 (protein-like and pigment derived compounds). Seasonal changes in MOD quality represent different breakdown stages of the allochthonous DOM. Our survey allowed us to record and discuss the effects of the Puyehue?Cordón Caulle eruption, showing that due to the high slopes, high current and discharge of the streams the volcanic material was rapidly exported to the Moreno Lake complex. Overall, this survey underscores the magnitude and timing of the allochthonous input revealing the terrestrial subsidy to food webs in Patagonian freshwaters, which are among the most oligotrophic systems of the world.","palabras_clave":"Dissolved organic matter|Forested catchments|Andean streams|North Patagonia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18696,"idioma_id":4,"titulo":"Microbial pelagic metabolism and CDOM characterization in a phytoplankton-dominated versus a macrophyte dominated shallow lake","resumen":"Dominant primary producer in macrophyte- or phytoplankton-dominated shallow lakes might imply differences in dissolved organic carbon (DOC) composition. We compared chromophoric dissolved organic matter (CDOM), plankton respiration (R), and bacterial (BP) and primary production (PP), in two contrasting shallow lakes. We hypothesized that DOC from the macrophyte-dominated lake would be qualitatively inferior, so that it can support a lower yield than DOC from the phytoplankton- dominated one. Macrophyte-dominated lake had more humic and aromatic CDOM, though molecular weight was similar in both lakes. A clear synchronism between lakes was observed in mean depth and several CDOM absorption coefficients, suggesting an external driver of the variation in DOC concentration and CDOM quality. The positive BPPP and BP-Chl-a correlations in the macrophyte dominated lake point out to a dependence of bacteria on phytoplankton for a supply of labile DOC. In turn, BP in the phytoplankton-dominated lake was balanced with grazing by HF (heterotrophic flagellates).  The significantly higher HB:DOC and HF:DOC carbon ratios in the phytoplankton-dominated lake also suggest that better DOC quality would mean relatively more efficient C transfer to higher trophic levels. According to PP:BP and PP:R ratios both lakes should be considered autotrophic, although the macrophyte-dominated lake would be comparatively more heterotrophic.","palabras_clave":"Alternative states|Macrophytes|Bacterial production"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18697,"idioma_id":4,"titulo":"Modeling Parasite Reduction Mechanisms in Chagas Disease","resumen":"Various procedures have been proposed to reduce parasitemia during Chagas disease. Here we analyze in detail models developed to predict the possible outcomes of two of these treatments. The model solutions reproduce available experimental population data and can be used as tools to help researchers to find a cure or, at least, an optimal treatment to reduce cardiac cell damage. In particular, we study how the phase diagram describing the infection outcome is modified by the application of the ganglioside GM1, finding the optimum concentration of the drug in terms of the parameters characterizing its influence on the parasite-host interaction. We also investigate the use of the non-pathogenic parasite T. rangeli to reduce T. cruzi load in a mixed infection, finding that this method is not effective against all T. cruzi strains. Furthermore, we compare phase portraits of the evolution of the disease for a single and a mixed infection, and evaluate the cell damage as a function of the time elapsed between both infections, remarking on the temporary protective effect of the reaction to T. rangeli.","palabras_clave":"parasite|Chagas disease|trypanosoma cruzi|trypanosoma rangeli|GM1|hormesis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18698,"idioma_id":4,"titulo":"Proliferation of effective interactions: Decoherence-induced equilibration in a closed many-body system","resumen":"We address the question of how weak perturbations, which are quite ineffective in small many-body systems,  can lead to decoherence and hence to irreversibility when they proliferate as the system size increases. This  question is at the heart of solid-state NMR. There, an initially local polarization spreads all over due to spin-spin  interactions that conserve the total spin projection, leading to an equilibration of the polarization. In principle,  this quantum dynamics can be reversed by changing the sign of the Hamiltonian. However, the reversal is usually  perturbed by nonreversible interactions that act as a decoherence source. The fraction of the local excitation  recovered defines the Loschmidt echo (LE), here evaluated in a series of closed N spin systems with all-to-all  interactions. The most remarkable regime of the LE decay occurs when the perturbation induces proliferated  effective interactions. We show that if this perturbation exceeds some lower bound, the decay is ruled by an  effective Fermi golden rule (FGR). Such a lower bound shrinks as N increases, becoming the leading mechanism  for LE decay in the thermodynamic limit. Once the polarization stayed equilibrated longer than the FGR time, it  remains equilibrated in spite of the reversal procedure.","palabras_clave":"DECOHERENCE|MANY-BODY SYSTEMS|LOSCHMIDT ECHO|EFFECTIVE INTERACTIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18699,"idioma_id":4,"titulo":"Nanoquasicrystalline Al-based Matrix \/ gamma-Al2O3 Nanocomposites","resumen":"Quasicrystalline aluminium alloys have been studied in the past years achieving higher strength than commercial Al alloys and retaining high strength at high temperature. In this work a quasicrystalline Al alloy matrix nanocomposite containing nanoceramic particles has been manufactured using ball milling and hot extrusion. For that purpose a nanoquasicrystalline Al-Fe-Cr-Ti alloy was manufactured by powder atomisation. Nanocomposites consisting of a  quasicrystalline Al-Fe-Cr-Ti \/ gammaAl2O3 nano particles were manufactured. The effect of ball milling time on the microstructure and microhardness of the nanocomposite powders was investigated. Bulk materials were produced by consolidation and hot extrusion. The microstructure and microhardness of the extruded materials were characterised.The milling regime behaviour is discussed, and shows three different steps that have a significant effect on the rate of change of uniformity of the reinforcement distribution, matrix microstructure, powder size distribution and its microhardness. No significant decomposition of the quasicrystalline phaseoccurred over 30 hours of milling. Strain increased and the crystallite size of the aluminium phase decreased with milling time, with the Al crystallite size reaching a steady state. Although the quasicrystalline phase decomposed during hot extrusion, the microhardness of the nanocomposite produced were significantly harder (227±3 &#956;HV500) than both the unreinforced quasicrystalline alloy (159±1 &#956;HV500) and crystalline aluminium nanocomposites reported in the literature. Methods and analysis of material behaviour put forward in this work inform further understanding and optimisation of this and other nanocomposite systems containing a metastable microstructure matrix.","palabras_clave":"Metal Matrix Composites|Quasicrystals|Aluminium|Ball Milling"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18700,"idioma_id":4,"titulo":"GUIDEWIRE ARTIFACT TRACKING ON IVUS","resumen":"Intravascular ultrasound (IVUS) allows the visualization of vessel wall tissue and plaque composition. Among others challenges in the computational analysis of IVUS, the retrieved images are rotated on its axis because of the catheter pullback, the tortuosity of the artery and the motion produced by the cardiac activity. The aim of the present work is to track the guidewire artifact present in IVUS images, which can lead to improve existing methods for 3D reconstruction and cardiac activity estimation, among others analysis. A minimum path along a graph that represents the correlation of the IVUS images with the guidewire artifact pattern is used to track the artifact.","palabras_clave":"IVUS|GUIDEWIRE ARTIFACT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18701,"idioma_id":4,"titulo":"A highly stable biocatalyst obtained from covalent immobilization of a non-commercial cysteine phytoprotease","resumen":"          In this work, araujiain  (enzymatic preparation obtained  from the latex of Araujia hortorum  fruits) was successfully immobilized on glyoxyl-agarose via multipoint covalent attachment. Thus, good  efficiency of immobilization and high operational stability of immobilized  enzyme were obtained. The  activity of araujiain at alkaline pH  was significantly improved after immobilization. In addition, immobilized araujiain also showed high activity and  good stability, without significant loss in its activity, at temperatures between  37 and 60° C and in the presence of immiscible organic solvents. Immobilized araujiain also showed good performance  in a mixture of 50% ethyl acetate in buffer, used for peptide synthesis, with  better results than when the free enzyme was used as catalyst. These results  indicate that immobilized araujiain  via multipoint covalent attachment can be highly stabilized and this method  might be used for practical applications of araujiain  in hydrolytic and synthetic processes.  ","palabras_clave":"Araujiain|Protease|Enzyme Technology|Immobilised Enzymes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18702,"idioma_id":4,"titulo":"Comparing galaxy populations in compact and loose groups of galaxies III. Effects of environment on star formation","resumen":"This paper is part of a series in which we systematically compare the properties of galaxies in compact groups, loose groups, and the field. In this paper we focus our study on the age and star formation in galaxies.  For galaxies in selected samples of compact groups, loose groups, and field galaxies, we compare the distributions of  D$_n(4000)$ as an age indicator and the specific star formation rate as an indicator of on-going star formation. We analyse the dependence of these parameters on galaxy type and stellar mass and, for group galaxies, their dependence on the dynamic state of the system. We study the relative fraction of galaxies dominated by old stellar populations as a function of galaxy stellar mass. We perform a similar analysis for galaxies that have high specific star formation rates.  Galaxies in compact groups have, on average, older stellar populations than their loose-group or field counterparts. Early-type galaxies in compact groups formed their stars and depleted their gas content more rapidly than in the other environments. We have found evidence of two populations of late-type galaxies in dynamically old compact groups: one with normal specific star formation rates and another with markedly reduced star formation.  Processes that transform galaxies from star forming to quiescent act upon galaxies faster and more effectively in compact groups. The unique characteristics of compact groups make them an extreme environment for galaxies, where the transition to quiescence occurs rapidly.","palabras_clave":"GALAXIES|FUNDAMENTAL PARAMETERS|EVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18703,"idioma_id":4,"titulo":"Wolbachia occurrence in planthopper (Hemiptera: Delphacidae) vectors of cereal viruses in Argentina","resumen":"Maize (Zea mays L.) and wheat (Triticum aestivum L.) are the most important cereal crops for the Argentinean economy and are affected by several diseases. Different planthopper species transmit causal agents of some of those diseases, including Mal de Río Cuarto virus, barley yellow striate mosaic virus, and the recently proposed maize yellow striate virus. Many planthopper species are sap feeders and therefore are expected to host bacteria providing essential nutrients lacking in the diet. Previous studies have evidenced that some of these bacterial symbionts are involved in the virus transmission. Wolbachia is a group of obligate intracellular bacteria infecting numerous arthropod species and causing reproductive alterations in their hosts. These bacteria have been detected in planthopper species, considered rice pests in various regions of the world. To date, Wolbachia infection status of planthopper species of Argentina is unknown. Amplification by PCR and sequencing of 16S rDNA, wsp- and ftsZ-specific genes demonstrated Wolbachia infection in Caenodelphax teapae (Fowler), Delphacodes kuscheli Fennah, Pyrophagus tigrinus Remes Lenicov & Varela, Tagosodes orizicolus (Muir), and Toya propinqua (Fieber). This is the first report of Wolbachia in delphacid vectors of viruses affecting maize and wheat. An understanding of the bacterial diversity harbored by these insect vectors could lead to new options for future management of diseases of economically important crops in a developing country.","palabras_clave":"WOLBACHIA|PLANTHOPPER|VECTOR|VIRUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18704,"idioma_id":4,"titulo":"Auxins action on Glycine max secretory phospholipase A2 is mediated by the interfacial properties imposed by the phytohormones","resumen":"Secretory phospholipase A2 (sPLA2) are soluble enzymes that catalyze the conversion of phospholipids to lysophospholipids and free fatty acids at membrane interfaces. The effect of IAA and IPA auxins over the activity of recombinant sPLA2 isoforms from Glycine max was studied using membrane model systems including mixed micelles and Langmuir lipid monolayers. Both phytohormones stimulate the activity of both plant sPLA2 using DLPC\/Triton mixed micelles as substrate. To elucidate the mechanism of action of the phytohormones, we showed that both auxins are able to self-penetrate lipid monolayers and cause an increment in surface pressure and an expansion of lipid\/phytohormone mixed interfaces. The stimulating effect of auxins over phospholipase A2 activity was still present when using Langmuir mixed monolayers as organized substrate regardless of sPLA2source (plant or animal). All the data suggest that the stimulating effect of auxins over sPLA2 is due to a more favorable interfacial environment rather to a direct effect over the enzyme.","palabras_clave":"Glycine max phospholipase A2 | Auxin stimulation |Interfacial catalysis |Soybean sPLA2s"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18705,"idioma_id":4,"titulo":"Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice","resumen":"Long-term memory formation requires gene expression after acquisition of new information. The first step in the regulation of gene expression is the participation of transcription factors (TFs) such as nuclear factor kappa B (NF-rB), which are present before the neuronal activity induced by training. It was proposed that the activation of these types of TFs allows a second step in gene regulation by induction of immediate-early genes (IEGs) whose protein products are, in turn, TFs. Between these IEGs, zif268 has been found to play a critical role in long-term memory formation and reprocessing after retrieval. Here we found in mice hippocampus that, on one hand, NF-rB was activated 45 min after training in a novel object recognition (NOR) task and that inhibiting NF-rB immediately after training by intrahippocampal administration of NF-rB Decoy DNA impaired NOR memory consolidation. On the other hand, Zif268 protein expression was induced 45 min after NOR training and the administration of DNA antisense to its mRNA post-training impaired recognition memory. Finally, we found that the inhibition of NF-rB by  NF-rB Decoy DNA reduced significantly the training-induced Zif268 increment, indicating that NF-rB is involved in the regulation of Zif268 expression. Thus, the present results support the involvement of  NF-rB activity-dependent Zif268 expression in the hippocampus during recognition memory consolidation.","palabras_clave":"Memory consolidation|Transcription factors|Zif268|NF-kB"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18706,"idioma_id":4,"titulo":"Wasmannia Forel (Hymenoptera: Formicidae: Myrmicinae) in Argentina:  Systematics and Distribution","resumen":"The ant genus Wasmannia is endemic to the Neotropics, with 10 species occurring within the presumptive native range for the genus from Mexico to Argentina. Only the little fire ant, Wasmannia auropunctata is widely distributed being present from central-eastern Argentina to Bermuda, and has become infamous due to its recent worldwide expansion and status as an invasive pest. The objective of this work was to study the systematics and distribution of Wasmannia in its southern limit of distribution in Argentina. Out of the three species reported so far  for Argentina, only W. auropunctata was found to be widely distributed, but abundant only in disturbed habitats mostly in northeastern Argentina. Herein, distribution of Wasmannia auropunctata is extended and its queen and male castes are redescribed, along with descriptions of gynandromorphs (specimens with left side of the head similar to a male and right side similar to a queen). Wasmannia sulcaticeps and W. williamsoni are reported to be much less common and widespread. W. sulcaticeps was mostly found in mountain forests in northwestern Argentina, whereas W. williamsoni was only found in shrublands and grasslands in central eastern Argentina, and most frequent in mountain grasslands. Both species overlapped with W. auropunctata, which is more common in the lowlands, between approximately 400 and 1000 m elevation. The queen of W. williamsoni and workers of both species are redescribed. Also queen and male of W. sulcaticeps are redescribed.  A new species, Wasmannia longiseta n. sp. Cuezzo and Calcaterra, recently found in northeastern Argentina is described based on the worker morphology. Wasmannia rochai is recorded for the first time in Misiones, extending its distribution range from São Paulo (Brazil) to Misiones in northeastern Argentina. A key to the worker caste including the new species of Wasmannia is provided. A cladistic analysis based on discrete and continuous morphological characters is presented as a first attempt to clarify the phylogenetic relationships between the known species of Wasmannia.","palabras_clave":"Wasmannia longiseta n. sp.|little fire ant |biogeography|taxonomy|phylogeny"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18707,"idioma_id":4,"titulo":"Neuston: a relevant trophic resource for apple snails?","resumen":"Apple snails are known for the strong impacts they provoke in wetlands and aquatic crops by  their macrophytophagous habits. Interestingly, they are able to persist after they have eradicated most palatable aquatic macrophytes in the invaded wetlands. Pedal surface collecting is a distinctive mechanism that apple snails use to capture materials in the water surface. We were interested in knowing the relevance of neuston, the organisms associated with the air-water interface, as an alternative trophic resource. Using the invasive Pomacea canaliculata as a model, our experiments with simulated trophic resources in the laboratory showed that neuston is highly consumed even in the presence of abundant palatable macrophytes. P. canaliculata was able to grow efficiently using neuston as an alternative trophic resource both under laboratory and natural conditions. Neuston probably plays a relevant role specially when other trophic resources are inedible or absent or have been depleted by apple snails. Pedal surface collecting probably evolved in apple snails as an adaptation to cope with fluctuating trophic resources.","palabras_clave":"Pomacea|feeding|wetland|invasion|macrophytes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18708,"idioma_id":4,"titulo":"Variability in size and age at maturity in the marine scavenger Buccinanops globulosus (Gastropoda: Nassariidae) from Patagonia","resumen":"Growth rates and size-age at maturity are life history traits combined in different ways to achieve maximal fitness. The marine scavenger Buccinanops globulosus was used as a model to explore the variation on female size-age at maturity and reproductive effort among three populations characterized by different growth rates (slow, moderate and rapid). This species constitutes the target of an artisanal fishery in North Patagonia. Here, a suite of different estimators of size-age at maturity derived from gonad histological analysis and the study of females carrying egg capsules were obtained. Data were modeled using a logistic function and the maturity patterns were compared among populations. We found that female size and age at maturity were variable and site-specific. The fastest growing population showed the lowest reproductive effort. Slow and rapid-growing females mature at different sizes but at the same age whereas moderate-growing females mature both at a different size and age (intermediate size and at earlier age). Thus, results obtained here are difficult to reconcile with a single reaction norm for a single genotype in the studied populations. Growth rate variation is not enough to explain the patterns here described. The information provided could be used for the establishment of fishery management actions, such as minimum landing size.","palabras_clave":"LIFE HISTORY|MATURITY|REPRODUCTION|WHELK FISHERY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18709,"idioma_id":4,"titulo":"Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation","resumen":"Abstract?Reconsolidation has been defined as the processof memory stabilization after retrieval involving, amongothers, gene expression regulation and post-translationalmodifications. Many of these mechanisms are shared withmemory consolidation. Here, we studied hippocampal ERKparticipation on memory reconsolidation of an inhibitoryavoidance task in CF-1 mice. We found a retrieval-inducedcytosolic ERK2 activation in the hippocampus (HIP) 15 minafter memory reactivation, and an inhibition at 45 min.PD098059, a MEK1\/2 (MAPK\/ERK kinase) inhibitor, administeredin the HIP immediately after retrieval impaired memoryin a dose-dependent fashion. However, infusions of thehighest dose of PD098059 performed 40 min after retrievalenhanced memory in mice trained with a weaker footshock.These results suggest for the first time that ERK2 is involvedin memory reconsolidation in a biphasic fashion.Furthermore, the inhibition of ERK could either impair orenhance mice performance depending on ERK state ofactivation.","palabras_clave":"Memory|Reconsolidation|ERK2"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18710,"idioma_id":4,"titulo":"Some remarks on graded nilpotent Lie algebras and the Toral Rank Conjecture","resumen":"If n is a Zd  +-graded nilpotent finite-dimensional Lie algebra over a field of characteristic  zero, a well-known result of Deninger and Singhof states that dim H&#8727;(n) &#8805; L(p) where  p is the polynomial associated to the grading and L(p) is the sum of the absolute  values of the coefficients of p. From this result they derived the Toral Rank Conjecture  (TRC) for 2-step nilpotent Lie algebras. An algebraic version of the TRC states that  dim H&#8727;(n) &#8805; 2dim(z) for any finite-dimensional nilpotent Lie algebra n with center z. The  TRC is more than 25 years old and remains open even for Zd  +-graded 3-step nilpotent Lie  algebras. Investigating to what extent the bound given by Deninger and Singhof could  help to prove the TRC in this case, we considered the following two questions regarding  a nilpotent Lie algebra n with center z: (A) If n admits a Zd  +-grading n = L  &#945;&#8712;Zd  +  n&#945;,  such that its associated polynomial p satisfies L(p) > 2dim z , does n admit a Z+-grading  n = n  1 &#8853;n  2 &#8853;···&#8853; n  k such that its associated polynomial p satisfies L(p  ) > 2dim z? (B)  If n is r-step nilpotent admitting a grading n = n1 &#8853;n2 &#8853;···&#8853;nk such that its associated  polynomial p satisfies L(p) > 2dim z , does n admit a grading n = n  1 &#8853; n  2 &#8853;···&#8853; n  r such  155002 that its associated polynomial p satisfies L(p  ) > 2dim z? In this paper we show that  the answer to (A) is yes, but the answer to (B) is no.","palabras_clave":"NILPOTENT LIE ALGEBRAS|GRADINGS|COHOMOLOGY|TORAL RANK CONJETURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18711,"idioma_id":4,"titulo":"CRYSTAL STRUCTURE, SPECTROSCOPIC AND THERMAL PROPERTIES OF [ZN(LAP)2(DMF)(H2O)] AND ISOMORPHOUS [M(LAP)2]N (M: CD, MN) COMPLEXES","resumen":"The crystal and molecular structure of the lapacholate complexes with Zn(II), Cd(II) and Mn(II) were determined by X-ray diffraction methods. [Zn(Lap)2(DMF)(H2O)] crystallizes in the triclinic space group P&#299; with a = 10.5051(4), b = 12.8020(4), c = 13.0394(4) Å, &#61537;= 60.418(2), &#61538; = 83.904(2), &#61543; = 86.206(2)°, and Z=2 molecules per unit cell and isostructural [M(Lap)2]n (M: Cd, Mn) complexes in the tetragonal space group P43212 with a = b = 13.5770(6) Å, c = 14.5730(6) Å for the Cd complex, and a = b = 13.3539(4), c = 14.7148(4) Å for the Mn complex, and Z = 4 molecules per unit cell. The structures were solved from 4984 (Zn), 2252 (Cd) and 2330 (Mn) reflections with I>2&#963;(I) and refined by full matrix least-square to agreement R1-factors of 0.0452 (Zn), 0.0315 (Cd) and 0.0333 (Mn). In [Zn(Lap)2(DMF)(H2O)], the Zn(II) ion is in a distorted octahedral environment coordinated to two different and nearly perpendicular Lap molecules acting as bidentate ligands through their adjacent carbonyl and phenol oxygen atoms. The remaining two cis-coordination sites are occupied by water and DMF molecules. [M(Lap)2]n (M: Cd, Mn) isostructural complexes are also octahedral and present a supra-molecular arrangement in the lattice. There is only one independent Lap molecule that coordinates the metal through all three ligand binding sites, giving rise to a 3-D structure of [M(Lap)2]n complexes that extends throughout the crystal lattice.","palabras_clave":"Lapacholate|Zn(II), Cd(II), and Mn(II) Complexes|Crystal Structures|Spectroscopic Properties"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18712,"idioma_id":5,"titulo":"Caracterización de las variables que causan las dificultades léxicas en estudiantes de ESP","resumen":"El estudio de un campo disciplinar demanda el acceso a bibliografía tanto en inglés como español. Sin embargo, gran parte de los alumnos universitarios carecen de las competencias lingüísticas para comprender textos en inglés. En los cursos de ESP se ha observado que durante la lectura de textos los estudiantes tienen dificultades en el procesamiento léxico resultando ser esto un obstáculo para el desarrollo de las competencias lingüísticas. El objetivo de este trabajo es detectar las variables que causan  las dificultades léxicas de los estudiantes de ESP valiéndose de la técnica 'think aloud' para agilizar el proceso de lectura. Esta experiencia se lleva a cabo con alumnos de las carreras del campo de las Ciencias Experimentales que cursan la asignatura Inglés Técnico. Los participantes, a partir de un texto en inglés, deben resolver distintas actividades en donde deben mostrar su competencia léxica. Se aplica la técnica de reporte verbal de pensamiento en voz alta (PVA) o 'think aloud', a través de la cual, los sujetos verbalizan lo que les pasa por la mente. Con este método, se puede indagar en su pensamiento, utilizando un dispositivo para registrar los procesos mentales. Estas verbalizaciones o protocolos se graban, se transcriben y por último se analizan. Se detectan algunas variables que dificultan el procesamiento léxico y que por ende obstaculizan el desarrollo de las competencias lectoras de los estudiantes. Estos resultados serán el punto de partida para bosquejar un instrumento que pueda contribuir a abordar esta problemática.","palabras_clave":"DIFICULTADES LÉXICAS|ESP|TÉCNICA PVA|VARIABLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18713,"idioma_id":4,"titulo":"Estimating   the self-depuration capacity of a reach of the Luján River.","resumen":"ABSTRACT: A 3-km reach of the Luján River was studied by establishing 6 sampling stations, which were from 300 to 500 m apart. The first station was the control reading for river nutrients and particulate material.The second station measured the continuous effluent from a wastewater treatment plant flow of the city of Luján and was, therefore, considered a continuous addition point of nutrients. The other 4 stations were usedto evaluate whether the river captured phosphorus as phosphate, nitrogen as ammonium, nitrite or nitrates, and the suspended particulate material, both organic and inorganic. These data were used to calculate materialuptake (U), uptake velocity (Vf), and net distance Snet under two different hydrological situations, during low and high flow, during the same season of the same year. Results indicate that phosphate ions as well as organic matter are retained for less than 2 km in both high and low flow situations. In the case of ammonium, the results appear similar to those of phosphate ions but it may be transformed into nitrates and transported in the latter form for greater distances. It is concluded that this river, in the reach under study, has a variable retentionspeed according to its flow but the retention capacity is no less than 900 m and as much as 2000 m. Therefore, a 2km distance must be considered as the minimum distance before another effluent of nutrients or organicmatter is added.","palabras_clave":"material uptake|nutrients|particulate matter|Lujan river"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18714,"idioma_id":4,"titulo":"Robust estimators for data reconciliation","resumen":"In this work, a comparative performance analysis of robust data reconciliation strategies is presented. The study involves two procedures based on the biweight function and three estimation techniques that use the Welsh, quasi-weighted least squares, and correntropy M-estimators. The aforementioned functions are selected for comparative purposes because their use in the data reconciliation literature has appeared during the past decade. All procedures are properly tuned to have the same estimation and gross error detection\/identification capabilities under the ideal distribution. Different measurement models are systematically taken into account, and results are analyzed considering both performance measures (average number of type I errors, global performance, mean square error) and computational load. The comparative analysis indicates that a simple robust methodology can provide a good balance between those two issues for linear and nonlinear benchmarks.","palabras_clave":"DATA RECONCILIATION|ROBUST STATISTICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18715,"idioma_id":5,"titulo":"El estudio de la proteinuria en la insuficiencia renal aguda: nuevos marcadores","resumen":"Un panel de biomarcadores urinarios permitiría detectar insuficiencia renal aguda de manera temprana y precisa; siendo incruento para una toma de decisiones terapéuticas. Las formas más frecuentes insuficiencia renal aguda son nefritis túbulo intersticial alérgica y necrosis tubular aguda con un diagnóstico diferencial establecido mediante biopsia renal como estándar de oro. La creatinina sérica, influenciada por la función renal preexistente, no permite precisar el tiempo y la severidad de la lesión. El examen del sedimentourinario detecta células y cilindros como único signo específico de lesión tubular renal; se aumentaría su sensibilidad cuantificando proteínas y enzimas urinarias. La &#946;2-microglobulina urinaria indica alteración de reabsorción tubular y sería superior a la N-acetil-&#946;-D-glucosaminidasa (lisosoma) para predecir evoluciones adversas. La fosfatasa alcalina (ribete en cepillo) es liberada rápidamente por alteración del túbulo proximal. La &#945;1-microglobulina detectaría alteración asintomática y la necesidad de establecer terapia dereemplazo. La proteína quimioatractante de monocitos-1 evidencia infiltración inflamatoria y edema intersticial. Por activación de sus genes, aumenta la proteína de injuria renal-1 (membrana tubular proximal). La gelatinasa del neutrófilo asociada a lipocalina posee valor diagnóstico y pronóstico dentro de las 6 hs. de la agresión o 24-48 hs. previas al diagnóstico. La albuminuria sería útil, puesto que la insuficiencia renal aguda activa la expresión de su gen. El perfil proteico mediante SDS-PAGE es una técnica no invasiva que permite definir glomerulopatía vs. tubulopatía, permitiendo detectar perfiles glomerulares asociadosa peores evoluciones en insuficiencia renal aguda. Puesto que es difícil contar con la histopatología debido a los riesgos asociados a la biopsia renal, resultaría conveniente identificar un conjunto de biomarcadores urinarios en la injuria renal aguda, útiles como indicadores de un proceso patológico o de una respuesta farmacológica a una intervención terapéutica, tanto en su diagnóstico como en el seguimiento de su evolución.","palabras_clave":"insuficiencia renal aguda|biomarcadores|disfunción tubular"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18716,"idioma_id":4,"titulo":"The Thickening of the Thin Disk in the Third Galactic Quadrant","resumen":"In the third Galactic quadrant ()   of the Milky Way, the Galactic thin disk exhibits a significant   warp?shown both by gas and young stars?bending down a few kiloparsecs   below the formal Galactic plane (). This warp shows its maximum at ,   in the direction of the Canis Major constellation. In a series of   papers, we have traced the detailed structure of this region using open   star clusters, putting particular emphasis on the spiral structure of   the outer disk. We noted a conspicuous accumulation of young star   clusters within 2?3 kpc from the Sun and close to b = 0°, which   we interpreted as the continuation of the Local (Orion) arm toward the   outer disk. While most clusters (and young stars in their background)   closely follow the warp of the disk, our decade-old survey of the spiral   structure of this region led us to identify three clusters, Haffner 18   (1 and 2) and Haffner 19, which remain very close to b = 0° and   lie at distances (4.5, ~8.0, and 6.4 kpc) where most of the material is   already significantly warped. Here, we report on a search for clusters   that share the same properties as Haffner 18 and 19, and investigate the   possible reasons for such an unexpected occurrence. We present UBVRI   photometry of five young clusters, namely NGC 2345, NGC 2374, Trumpler   9, Haffner 20, and Haffner 21, which also lie close to the formal   Galactic plane. With the exception of Haffner 20, in the background of   these clusters we detected young stars that appear close to    and are located at distances up to ~8 kpc from the Sun, thus deviating   significantly from the warp. These populations define a structure that   distributes over almost the entire third Galactic quadrant. We discuss   this structure in the context of a possible thin disk flaring, similar   to the Galactic thick disk.","palabras_clave":"Galaxy|Structure|Milky|Way"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18717,"idioma_id":4,"titulo":"The nearby Galaxy structure toward the Vela Gum nebula","resumen":"We report on UBVI photometry and spectroscopy for MK classification purposes carried out in the fields of five open clusters projected against the Vela Gum in the Third Galactic Quadrant of the Galaxy. They are Ruprecht 20, Ruprecht 47, Ruprecht 60, NGC 2660 and NGC 2910. We could improve\/confirm the parameters of these objects derived before. Ruprecht 20 is not a real physical entity, in agreement with earlier suggestions. Ruprecht 47, a young cluster in the Galactic plane, at 4.4 kpc from the Sun is quite farther than in previous distance estimations and becomes, therefore, a member of the Puppis OB2 association. For the first time Ruprecht 60 was surveyed in UBVI photometry. We found it to be placed at 4.2 kpc from the Sun of about and 1 Gyr old. NGC 2660 is another old object in our survey for which distance and age are coincident with previous findings. NGC 2910 turns out to be a young cluster of Vela OB1 association at a distance of 1.4 kpc approximately and 60 Myr old. The spectroscopic parallax method has been applied to several stars located in the fields of four out of the five clusters to get their distances and reddenings. With this method we found two blue stars in the field of NGC 2910 at distances that make them likely members of Vela OB1 too. Also, projected against the fields of Ruprecht 20 and Ruprecht 47 we have detected other young stars favoring not only the existence of Puppis OB1 and OB2 but conforming a young stellar group at &#8764; 1 kpc from the Sun and extending for more than 6 kpc outward the Galaxy. If this is the case, there is a thickening of the thin Galactic disk of more than 300 pc at just 2-3 kpc from the Sun. Ruprecht 60 and NGC 2660 are too old objects that have no physical relation with the associations under discussion. An astonishing result has been the detection in the background of Ruprecht 47 of a young star at the impressive distance of 9.5 kpc from the Sun that could be a member of the innermost part of the Outer Arm. Another far young star in the field of NGC 2660, at near 6.0 kpc, may become a probable member of the Perseus Arm or of the inner part of the Local Arm. The distribution of young clusters and stars onto the Third Galactic Quadrant agrees with recent findings concerning the extension of the Local Arm as revealed by parallaxes of regions of star formation. We show evidences too that added to previous ones found by our group explain the thickening of the thin disk as a combination of flare and warp.","palabras_clave":"Milky|Way|Structure|Spiral|Arms"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18718,"idioma_id":4,"titulo":"Filling the gap: new precise Early Cretaceous radioisotopic ages from the Andes","resumen":"Two tuffs in the Lower Cretaceous Agrio Formation, Neuquén Basin, provided U?Pb zircon radioisotopic ages of 129.09±0.16 Ma and 127.42±0.15 Ma. Both horizons are well constrained biostratigraphically by ammonites and nannofossils and can be correlated with the ?standard? sequence of the Mediterranean Province. The lower horizon is very close to the base of the Upper Hauterivian and the upper horizon to the Hauterivian\/Barremian boundary, indicating that the former lies at c. 129.5 Ma and the latter at c. 127 Ma. These new radioisotopic ages fill a gap of over 8 million years in the numerical calibration of the currentglobal Early Cretaceous geological time scale.","palabras_clave":"NEUQUEN BASIN|HAUTERIVIAN|BIOSTRATIGRAPHY|AMMONOIDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18719,"idioma_id":4,"titulo":"POLYMORPHIC VARIANTS OF GSTM1, GSTT1 AND GSTP1 GENES IN CHILDHOOD ACUTE  LEUKEMIAS: A PRELIMINARY STUDY IN ARGENTINA","resumen":"Background and Aim: Despite recent major advances in leukemia research, the etiopathogenesis of childhood leukemias remains far elusive. Individual predisposing factors, including polymorphisms in  detoxification enzymes, have been implicated in the molecular pathogenesis and heterogeneity of the disease. Genetic polymorphisms of glutathione S-transferases (GSTs) that alter enzyme activity could be  an additional factor that increases the risk of acute leukemia, but data are lacking in Argentina. We assessed the association of GST polymorphisms and the susceptibility to childhood leukemia in Argentina  by conducting an exploratory case-control study and correlated patients? genotype to clinical and biological features.  Methods: Deletion polymorphisms in GSTM1 and GSTT1 genes and the single nucleotide polymorphism in GSTP1 c.319A>G (rs1695; p.105Ile>Val) were genotyped by PCR methods in 36 patients and 133 healthy  individuals.  Results: GSTM1-null genotype was associated with a lower risk of developing acute leukemia (P = 0.013; OR:0.31; CI: 0.12?0.80), while GSTP1-GG variants displayed an increased risk (P = 0.01; OR: 3.9; CI: 1.85?8.2).However, no differences were found for GSTT1 gene.  Conclusion: These preliminary results, to be validated in a larger population from Argentina, suggest that the development of pediatric leukemia may be differentially influenced by genotypic variants in GST genes","palabras_clave":"Polimorfismo|Leucemia Aguda|GST"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18720,"idioma_id":4,"titulo":"Isolation of Bordetella Species from  Unusual Infection Sites","resumen":"ntroduction:Bordetella hinzii has been isolated mainly from respiratory specimens and from blood of immunocompromised patients, and Bordetella trematumfrom ear infections or leg, arm and ankle wounds and from diabetic foot ulcers.Bordetella holmesii is instead associated with bactaeremia in young adults, mostly with underlying conditions. Only three septic arthritis cases due to this species have been described in the literature.Case presentation:Herein we describe four cases of infections due to Bordetellaspecies that have been recovered from unusual infection sites: two cases ofB. hinzii infections, one recovered from the urine of a patient with chronic prostatitis and the other from a liver cyst in an immunocompetent patient; oneB. trematum case from a bone biopsy of a patient with chronic osteomyelitis of the hip; and one B. holmesii case isolated from the joint fluid of animmunocompetent patient with diagnosed septic arthritis.The organisms were identified using standard biochemical tests, by API 20 NE version 6.0, by automated system VITEK 2, by mass spectrometry using the Bruker Daltonics MicroFlex LT spectrometer with MALDI Biotyper 3.1, and by PCR amplification of 16S rRNA. Antibiotic susceptibility testing was performed using the VITEK 2 system, except for B. holmesii, for which the epsilometric method (Etest technique; bioMerieux) was used. Conclusion:We highlight the importance of isolating Bordetella species from severe infections and unusual sites, and also of combining both phenotypic and genotypic methods for definitive identification","palabras_clave":"Bordetella infections|species-dependent antibiotic susceptibility|unusual infection sites"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18721,"idioma_id":5,"titulo":"ALGUNAS CONSIDERACIONES SOBRE LOS ROLES DE LA MUJER EN NUESTRA CULTURA ACTUAL. UNA ARTICULACIÓN ENTRE EL PSICOANALISIS Y LOS ESTUDIOS DE GENERO.","resumen":"Este trabajo se enmarca en el Proyecto de Investigación Consolidado N° 12-0614 y 22\/P407, que indaga la crisis de la edad media de la vida en la mujer a partir de la articulación entre las conceptualizaciones psicoanalíticas y los estudios de género.  El objetivo de la presente comunicación es analizar las características que adquieren los roles de ama de casa, trabajadora y madre durante la mediana edad en nuestra cultura. Se analizan además las variaciones en el desempeño de los mismos a lo largo de la historia, tomando en consideración la incidencia de los estereotipos sociales.   El desarrollo de la mente es el resultado no sólo de los vínculos familiares estrechos sino también de imaginarios sociales instituidos. Las determinaciones de género, articuladas con la etnia, la clase social, la edad, la religión y la orientación sexual, constituyen una referencia obligada para la comprensión de la subjetividad. Los roles de género le confieren a hombres y mujeres un lugar y una función en la sociedad.  En el contexto cultural actual las representaciones tradicionales de lo femenino y lo masculino atraviesan por un proceso de crisis que genera profundas ansiedades.  La mujer de hoy matiza cada vez más sus modelos identificatorios, recuperando aquellos emblemas de femineidad tradicional que resulten posibles de integrar con la condición ciudadana y con el despliegue de las potencialidades creativas individuales. Sin embargo, coexiste también un estilo de relaciones familiares en el que persiste la división sexual del trabajo, la complementariedad de los roles, la polarización de las identidades genéricas y el dominio masculino.","palabras_clave":"PSICOANALISIS|FEMINIDAD|ROLES DE GENERO|MEDIANA EDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18722,"idioma_id":4,"titulo":"Academic Performance Profiles: A Descriptive Model Based on Data Mining","resumen":"Academic performance is a critical factor considering that poor academic performance is often associated with a high attrition rate. This has been observed in subjects of the first level of Information Systems Engineering career (ISI) of the National Technological University, Resistencia Regional Faculty (UTN-FRRe), situated in Resistencia city, province of Chaco, Argentine. Among them is Algorithms and Data Structures, where the poor academic performance is observed at very high rates (between 60% and about 80% in recent years). In this paper, we propose the use of data mining techniques on performance information for students of the subject mentioned, in order to characterize the profiles of successful students (good academic performance) and those that are not (poor performance). In the future, the determination of these profiles would allow us to define specific actions to reverse poor academic performance, once detected the variables associated with it. This article describes the data models and data mining used and the main results are also commented.","palabras_clave":"ACADEMIC PERFORMANCE PROFILES|DATA WAREHOUSES|DATA MINING|KNOWLEDGE DISCOVERY IN DATABASES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18723,"idioma_id":5,"titulo":"Impactos de las políticas públicas de hábitat en la configuración del espacio urbano entre 2003 y 2013.  El caso del área metropolitana de Tucumán, Argentina-MP-","resumen":"En virtud de las transformaciones socioeconómicas que se producen con posterioridad a la crisis2001-2002, el Estado argentino implementó nuevas lógicas en materia de política habitacional.La provincia de Tucumán fue una de las principales receptoras de fondos en este sentido,por lo que se propone como ámbito de estudio de esta investigación al área metropolitana deTucumán, con un crecimiento urbano significativo en la última década. Este trabajo analizalas consecuencias urbanas, en particular, las producidas por el conjunto de programas sociohabitacionalesde producción de vivienda, a fin de comprobar las continuidades y rupturas conrespecto a planes anteriores. Se analiza el cumplimiento del rol del Estado como promotor delfortalecimiento y la integración comunitaria mediante dos escalas estudio: una metropolitanay otra barrial. En la primera se tuvieron en cuenta principalmente los efectos espaciales enla conformación del aglomerado metropolitano, y en la segunda, aspectos de carácter social.","palabras_clave":"POLITICAS PUBLICAS|VIVIENDA|AREA METROPOLITANA|DESIGUALDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18724,"idioma_id":4,"titulo":"Renal dopaminergic system: Pathophysiological implications and clinical perspectives","resumen":"Fluid homeostasis, blood pressure and redox balance in the kidney are regulated by an intricate interaction between local and systemic anti-natriuretic and natriuretic systems. Intrarenal dopamine plays a central role on this interactive network. By activating specific receptors, dopamine promotes sodium excretion and stimulates anti-oxidant and anti-inflammatory pathways. Different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome, hypertension and renal inflammation, can be associated with impaired action of renal dopamine including alteration in biosynthesis, dopamine receptor expression and signal transduction. Given its properties on the regulation of renal blood flow and sodium excretion, exogenous dopamine has been postulated as a potential therapeutic strategy to prevent renal failure in critically ill patients. The aim of this review is to update and discuss on the most recent findings about renal dopaminergic system and its role in several diseases involving the kidneys and the potential use of dopamine as a nephroprotective agent.","palabras_clave":"DOPAMINE|KIDNEY|OXIDATIVE STRESS|SIGNAL TRANSDUCTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18725,"idioma_id":4,"titulo":"Action of anti-M3 muscarinic acetylcholine receptor IgG of primary Sjögren's syndrome on the enzymatic antioxidant system in rat submandibular gland.","resumen":"BACKGROUND: We demonstrate that serum immonuglobulin G (IgG) directed against glandular M3 muscarinic acethylcholine receptors (M3 mAChR) and pilocarpine triggers the increment of superooxidase dismutase (SOD) and catalase (CAT) and the production of nitric oxide (NO) and prostaglandin E2 (PGE2). METHODS: Enzyme-linked immunoabsorbent assay (ELISA) was performed in the presence of the human M3 mAChR synthetic peptide as antigen to detect in serum of pSS patients the autoantibodies. Further, SOD and CAT specific activity and NO were determined chemically in the presence of anti-M3 mAChR IgG and pilocarpine. The level of PGE2 generation in the presence of autoantibody and pilocarpine was  determined by ELISA. RESULTS: An association between anti-M3 mAChR autoantibodies and pilocarpine given the increment of the specific activity of SOD and CAT in the serum of pSS patients and in the rat submandibular gland was observed. As a result of this action, M3 synthetic peptide and atropine abrogated the stimulatory action. The L-type calcium channel, calcium\/calmodulin complex and COX-2 inhibitors selectively blocked the increment of the specific activity of SOD and CAT in the rat submandibular gland. An increased production of NO and PGE2 by the cholinergic autoantibody and pilocarpine was also been detected.  CONCLUSION: On the basis of these results, the increment of the specific activity of SOD and CAT in pSS patients as compared to control healthy individuals may be seen as a defensive reaction to the increment of the amount of ROS in the body, which becoming uncontrollable, leads to irreversible cellular and tissue damage.","palabras_clave":"AUTOANTIBODIES|SJOGREN SYNDROME|SOD\/CAT|PGE2"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18726,"idioma_id":5,"titulo":"?\tRiesgo de contaminación del agua subterránea con plaguicidas en la cuenca del arroyo El Cardalito, Argentina","resumen":"La cuenca del arroyo El Cardalito (102.6 km2) se encuentra localizada en el sudeste de la provincia de Buenos Aires (Argentina) cerca de la ciudad de Mar del Plata, donde existe un importante cinturón hortícola con uso intensivo de agroquímicos. El objetivo del trabajo consistió en estimar el riesgo potencial de lixiviación de los herbicidas, insecticidas y fungicidas comúnmente utilizados en dicha cuenca. A tal fin, se utilizaron los índices conocidos como factor de retardo (RF) y factor de atenuación log-transformado (AFT). Tanto el RF como el AFT se calcularon para los horizontes A, B y C de las cinco series de suelo que integran esta cuenca, así como para el perfil completo, teniendo en cuenta sus propiedades y profundidad. Considerando el RF, la capacidad de lixiviar de los plaguicidas fue superior en el horizonte C de los suelos respecto de los horizontes A y B o el perfil. En ese horizonte, los insecticidas con mayor movilidad fueron carbofuran, pirimicarb, metamidofós, imidacloprid y tiametoxam mientras que en el caso de los fungicidas fueron fosetil aluminio, Captan, zineb y carbendazim. Por su parte, se estimó que 12 de 25 herbicidas considerados presentaron elevada movilidad, especialmente dicamba, picloram y naptalam. En el caso del AFT, se determinó, para la mayoría de los plaguicidas, que la capacidad de lixiviar varió según el horizonte considerado de acuerdo al orden C > A > B, mientras que para todos los horizontes la peligrosidad se incrementó al aumentar la recarga neta, siendo máxima a 2.3 mm día-1. Por último, considerando el perfil de suelo, se determinó que la lixiviación de la mayoría de los plaguicidas evaluados, a excepción de Picloram, sería improbable a muy improbable para las recargas estudiadas (0.3, 1.1 y 2.3 mm día-1). Si bien los índices utilizados constituyen valiosas herramientas para estimar la vulnerabilidad de los acuíferos por lixiviación de plaguicidas, resulta imprescindible la realización de monitoreos a campo que verifiquen el grado de asociación con la realidad.","palabras_clave":"Factor de retardo|Factor de atenuación|Lixiviación|Herbicidas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18727,"idioma_id":4,"titulo":"Theoretical study of the ionization of liquid water from its several initial orbitals by fast electron impact","resumen":"We theoretically study the single ionization of liquid water by energetic electrons through one active-electron first-order model. We analyze the angular ejected electron spectra corresponding to the most external orbitals 1B1, 2A1, 1B2 and 1A1 of a single water molecule. We work to create a realistic description of those orbitals corresponding to single molecules in the liquid phase. This goal is achieved by means of a Wannier orbital formalism. Multiple differential cross sections are computed and compared with previous calculations for both liquid and gas phases. In addition, our present results are integrated over all orientations and compared with experimental ones for randomly oriented vapour water molecules, as no experiments currentlyexist for the liquid phase. Moreover, we estimate the influence reaction by means of a model potential.","palabras_clave":"LIQUID WATER|IONIZATION|ELECTRON IMPACT|WANNIER ORBITALS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18728,"idioma_id":5,"titulo":"Las relaciones entre la actividad física, el trabajo y la salud","resumen":"Para poder reflexionar sin quedar reducidos solamente a la problemática recreativa y deportiva -o de mantenimiento del buen estado físico, cuidado de la estética y combate a la obesidad-, es conveniente adoptar una concepción holística y analizar de manera global las inter-relaciones entre la actividad física, el trabajo y la salud.  Nuestra tesis sería que la adecuada actividad física es una condición necesaria para poder trabajar de manera eficiente y con calidad, pero las condiciones y el medio ambiente en las que se efectúa el trabajo tienen repercusiones sobre la salud, no solo física sino también psíquica y mental, cuyas manifestaciones se somatizan.","palabras_clave":"ACTIVIDAD FÍSICA|TRABAJO|SALUD DE LOS TRABAJADORES|TRABAJO DECENTE|CONDICIONES Y MEDIO AMBIENTE DE TRABAJO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18729,"idioma_id":4,"titulo":"Development and characterization of new enzymatic modified hybrid calcium carbonate microparticles to obtain nano-architectured surfaces for enhanced drug loading","resumen":"Hypothesis: Biopolymer?CaCO3 hybrid microparticles exposed to hydrolytic enzymes can provide new surface tailorable architectures. Soluble Alginate Lyase hydrolyzed alginate chains exposed on microparticle surface are generating considerable matrix changes. The change of porosity and surface to volume ratio is expected to influence absorption of drugs, thereby affecting controlled release profiles. The developed hybrid system potentially shows interesting properties for lung drug administration.Experimental: Hybrid microparticles were developed by colloidal co-precipitation of CaCO3 in presence of biopolymers: alginate (Alg) or Alg?High Methoxylated Pectin (HMP), followed by treatment with Alginate Lyase (AL). Surface architectures were observed by SEM. The increase in area to volume ratio was confirmed by BET isotherms. Also, enzymatic changes were elucidated by biophysical methods (EDAX, DSC, FTIR, XRD) and determination of the total carbohydrates content. Levofloxacin (a fluoroquinolone antibiotic) as model drug was incorporated by absorption. The drug release profile and the antimicrobial activity of the microparticles were tested against Pseudomonas aeruginosa.Findings: After enzyme treatment, microspheres showed 4 lm diameter and increased porosity. While CaCO3-Alg microspheres resulted in a rougher surface, CaCO3-Alg-HMP ones exhibited ??nano-balloon?? patterns on surface. Both AL-treated microparticles showed up to 3 and 7 times higher Levofloxacin encapsulation than no treated ones. Microparticles showed controlled drug release profiles and enhanced antimicrobial effect. The present work demonstrates a significant progress in the development of new carriers with potential application for lung infections treatment.","palabras_clave":"Calcium carbonate|Hybrid systems|Alginate|Pectin|Microparticles|Alginate lyase|Levofloxacin| Drug loading| Controlled release"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18730,"idioma_id":4,"titulo":"Female reproductive biology of the lizards Liolaemus sarmientoi and L. magellanicus from the southern end of the world","resumen":"Lizards that live in the harsh climate of the Argentinean Patagonia (40°?53° S) are active for a period restricted to spring and summer when vitellogenesis, pregnancy and birth take place. Herein, we present data on the female reproductive cycle, body size at sexual maturity, litter size and fat-body cycle of one of the world´s southernmost reptiles, Liolaemus sarmientoi. We also provide preliminary data on the reproductive cycle of a sympatric species, L. magellanicus. Females of both species start vitellogenesis in late spring, probably arrested or continued at very low rates during brumation resumed in the spring of the next year. Pregnancy starts in spring and births of L. sarmientoi (2 to 7 offspring) and L. magellanicus (3 to 4 offspring) occur over a month in midsummer. Females that give birth earlier can start a new vitellogenic cycle before autumn and perform an annual reproductive cycle. However, females which give birth later delay the start of a new vitellogenic cycle until the next spring, performing a biennial reproductive cycle. Thus, females have the potential to adjust their frequency of reproduction according to the energetic restrictions imposed by environmental conditions in the southernmost lands of South America. ","palabras_clave":"LIZARDS REPRODUCTION|ANNUAL-BIENNAL CYCLE|COLD CLIMATE|SOUTHERN PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18732,"idioma_id":4,"titulo":"DNA damage induced by bare and loaded Microporous Coordination Polymers from their ground and electronic excited states","resumen":"We report on interactions of cell free double-stranded DNA (dsDNA)  with a selected subgroup of Microporous Coordination Polymers  (MCPs). In particular, we have studied the influence of different  metal ion constituents and chemically modified linkers using a set  of five benzene carboxylate-based MCPs. Our results suggest that  the DNA moiety can be structurally modified in two different ways:  by direct MCPs-dsDNA interaction and\/or through photosensitized  processes. The extent of the observed damage was found to be  strongly dependent on the charge density of the material. The  potential use of the MCPs tested as inert carriers of photosensitizers  was demonstrated by analyzing the interaction between dsDNA and  harmine-loaded Cr-based materials, both in the absence of light  and upon UVA irradiation.","palabras_clave":"DNA DAMAGE|MICROPOROUS COORDINATION POLYMERS|PHOTOSENSITIZERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18733,"idioma_id":4,"titulo":"Phylogeny and floral trait evolution in Jaborosa (Solanaceae)","resumen":"The genus Jaborosa (Solanaceae), which comprises 22 species endemic to southern South America, encompasses remarkable flower variation. To test if this interspecific variation is related to transitions in pollination mode and to major concomitant geological changes, phylogenetic relationships within the genus were reconstructed. To determine when such major transitions in flower traits occurred, divergence times were estimated and the evolution of relevant floral traits was studied. Sequences of four plastid spacer regions (trnH-pbsA, trnDGUC-trnTGGU, rpl32-trnLUAG, ndhF-rpl32) and one nuclear region (granule-bound starch synthase) were used to resolve relationships among 18 Jaborosa species, using species of the `Atropina clade´ as outgroup. Phylogenetic reconstruction strongly supports the monophyly of Jaborosa, with species resolved in two major clades: i) a ?Lowland clade? (L) comprised of three noticeably sphingophylous species distributed below 1,000 m and north of 36° S latitude, and ii) an ?Andean clade? (A) composed of the remaining species, which strongly differ in floral morphology and mainly occur at high altitudes (more than 3,000 m in the Puna desert) or high latitudes (up to 53° S latitude in the Patagonia steppe of Tierra del Fuego). Species in the Andean clade have flowers that range from black, rotate, deceptive, saprophilous fly-pollinated flowers to green, tubular, nectar-producing flowers with a mixed pollination system. Estimation of divergence times suggests a split of Jaborosa from its sister genus Atropa L. at ca. 16.69 million years ago (mya). The split between the L and A clades possibly occurred ca. 10 mya, with recent species diversification co-occurring with the uplift of the Andes during the Pleistocene (ca. 1 to 3 mya). Reconstruction of ancestral states of pollination mode, altitudinal distribution, and floral traits (corolla colour, flower morphology, presence of nectar) suggests that pollination by moths probably evolved once within the L clade, whereas brood-site deceptive pollination probably evolved once within the A clade. These contrasting pollination modes are associated with changes in corolla colour, flower morphology and loss of a functional nectary.","palabras_clave":"hawkmoth pollination|Jaborosa|phylogeny|Solanaceae|southern South America|saprophilous fly pollination"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18734,"idioma_id":4,"titulo":"An Energy-aware Performance Analysis of SWIMM: Smith-Waterman Implementation on Intel's Multicore and Manycore","resumen":"Alignment is essential in many areas such as biological, chemical and criminal forensics. The well-known Smith-Waterman (SW) algorithm is able to retrieve the optimal local alignment with quadratic time and space complexity. There are several implementations that take advantage of computing parallelization, such as many-cores, FPGAs or GPUs, in order to reduce the alignment effort. In this  research, we adapt, develop and tune the SW algorithm named SWIMM on a  heterogeneous platform based on Intel?s Xeon and Xeon Phi coprocessor. SWIMM is a free tool avaliable in a public git repository  https:\/\/github.com\/enzorucci\/SWIMM. We efficiently exploit data and thread-level  parallelism, reaching up to 380 GCUPS on heterogeneous architecture, 350 GCUPS for the isolated Xeon and 50 GCUPS on Xeon Phi. Despite the heterogeneous implementation obtaining the best performance, it is also the most energy demanding. In fact, we also present a trade-off analysis between performance and  power consumption. The greenest configuration is based on an isolated multicore system which exploits AVX2 instruction set architecture reaching 1.5 GCUPS\/Watts.","palabras_clave":"bioinformatics|HPC|Heterogeneous computing|green computing"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18735,"idioma_id":4,"titulo":"Analysis and Comparison of Biased Affine Estimators","resumen":"Affine biased estimation is particularly useful when there is some a-priori knowledge on the parameters that can be exploited in adverse situations (when the number of samples is low, or the noise is high). Three different affine estimation strategies are discussed, namely the Deepest Minimum Criterion (DMC), the Min-Max (MM), and the Linear Matrix Inequality (LMI) strategies, and closed form expressions are obtained for all of them, for the case when the a priori knowledge is given in the form of ellipsoidal constraints on the parameter space, and when the covariance matrix of the unbiased estimator is constant. A relationship between affine estimation and Bayesian estimation of the mean of a multivariate Gaussian distribution with Gaussian prior is established and it is shown how affine estimation theory can help in the choice of the Gaussian prior distribution","palabras_clave":"AFFINE BIAS|BAYESIAN ESTIMATION|BIASED ESTIMATION|CONSTRAINED ESTIMATORS|LEAST-SQUARES METHODS|NONLINEAR OPTIMIZATION|PARAMETER ESTIMATION|POSITIVE DEFINITE MATRICES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18736,"idioma_id":4,"titulo":"Clinal variability of oil and nectar rewards in Monttea aphylla (Plantaginaceae): relationships with pollinators and climatic factors in the Monte Desert","resumen":"Monttea aphylla flowers simultaneously produce oil and nectar, rewards known to differentially attract ecologically  and functionally distinct pollinators. We examined whether geographical differentiation occurred for rewards, and  whether this could be explained by spatially heterogeneous pollinator guilds and climate. Rewards were measured  across the entire species range. Geographical patterns of reward quantity and their relationships with biotic and  abiotic factors were examined using uni- and multivariate analyses. Latitude significantly explained population  variation in nectar and oils, although in contrasting ways. Pollinator assemblages showed a prevalence of  oil-collecting Centris bees.Centris vardyorum, specialized on M. aphylla, showed a latitudinal pattern of visits. Oil  production was not higher where plants associated with ecologically specialized bees (i.e.C. vardyorum), but this  occurred instead where they were less frequent and co-occurred with other bees that used many floral sources,  including other plant species that produce oil. The multivariate analysis showed that the prevalence of C. var-dyorumwas the factor that contributed most significantly to the combined patterns of rewards. We suggest that  large-scale variation in rewards involves local optima throughout the species range, related to processes that  operate in each ecoregion with their particular biotic and abiotic scenarios.","palabras_clave":"geographical variation|Phytogeography, |pollination | floral evolution"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18737,"idioma_id":4,"titulo":"Expression of E2 and E7 HPV16 proteins in pre-malignant and malignant lesions of the uterine cervix","resumen":"Continuous production of the E7 protein from different types of high risk human papilloma virus (HPV) is required for progression of malignancy. We developed antibodies against HPV type 16 E7 and E2 proteins to evaluate their utility as markers for diagnosis during early stages of cervical cancer. Forty biopsies from uterine cervices were diagnosed as low grade intraepithelial lesion (LSIL), high grade intraepithelial lesion (HSIL), squamous carcinoma (SC), in situ adenocarcinoma (ISA) and invasive adenocarcinoma (AC), all of which were infected with HPV 16. Immunohisto- chemistry was used to investigate the expressions of E7 and E2 (both from HPV 16) and p16. P16 was expressed in eight of 12 LSILs, in all HSILs, in 16 of 18 SC and in all ACs. E2 was expressed in six of 12 LSILs. E7 was positive in eight of 12 LSILs and in all HSIL and carcinomas. The expres- sions of E2 and E7 of HPV16 related to p16 expression confirmed the value of the viral oncogenic proteins as complementary to histology and support the carcinogenic model of the uterine cervix, because HPVDNA integration into cellular DNA implies the destruction of the gene encoding E2, which suppresses the expression of the E6 and E7 oncoproteins. E2 from HPV16 could be marker for LSILs, while E7 could be a marker for progression of LSILs to HSILs in patients infected by HPV16, because viral typing has little positive predictive value.","palabras_clave":"adenocarcinoma|papillomavirus|biomarkers|E2 E7"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18738,"idioma_id":4,"titulo":"Levels of Cytokines and Matrix Metalloproteinases 2 and 9 in the Synovial Fluid of Osteoarthritic Horses Treated with Pamidronate","resumen":"AbstractThe aim of this study was to evaluate the effect of pamidronate on the clinical score and the secretory profile of inflammatory biomarkers (interleukin [IL]-6, tumor necrosis factor alpha [TNF-&#945;], matrix metalloproteinase [MMP]-2, and MMP-9) in the synovial fluid in clinically healthy horses and in horses with joint disease. Healthy horses and horses with joint symptoms were examined and subjected to a standardized clinical evaluation of the locomotor system. The clinical condition was evaluated by a global score. Matrix metalloproteinases 2 and 9 were measured by gel zymography. The concentration of cytokines (IL-6 and TNF-&#945;) in synovial fluid was determined by enzyme linked immunosorbent assay (ELISA). Pamidronate treatment significantly improved the clinical condition of horses with osteoarthritis (OA). Values of IL-6 (pg\/mL) were similar (ns) in the healthy control group (102.2 ± 26.94) and at day 3 of treated (TD) group (113.9 ± 18.33). Tumor necrosis factor alpha level, at day 3 of treatment, was significantly lower in TD groups than in untreated osteoarthritis. Treated group registered a fast increase in MMP-9 activity but till days 21 and 60 it was not detectable. No significant differences were found in the MMP-2 activity between groups. We concluded that treatment with pamidronate has a beneficial effect on the clinical score of horses with OA and can reduce proinflammatory cytokines (IL-6 and TNF-&#945;) and MMP-9 at different stages after treatment.","palabras_clave":"Horse,  |Cytokine, |Matrix metalloproteinase,| Osteoarthritis|Pamidronate,"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18739,"idioma_id":4,"titulo":"Gene expression and enzyme function of two cytochrome P450 3A isoenzymes in rat and cattle precision cut liver slices","resumen":"1. Precision-cut liver slices are one of the in vitro models used in studies concerning xenobiotic metabolism. Sparse information on this field is actually available for cattle and other veterinary species.2. The aim of the current work was to study the effect of dexamethasone (DEX) on the gene expression and function of CYP3A23 (in rat), CYP3A28 (in cattle) and the transcriptional factors involved in their regulation.3. DEX (at 100 mM) up-regulated CYP3A23 mRNA (3.2-fold, p¼0.028) in rat liver slices after 12 h culture, whereas the gene expression profiles of transcriptional factors involved in CYP3A regulation were unaffected. A CYP3A-dependent enzyme activity (triacetyl-oleandomycin N-demethylase) increased 3.4-fold (p50.05) in rat liver slices cultured in the presence of DEX.4. The protocol used for rat liver slices was used as reference to study the expression of a CYP3A isoenzyme in cattle liver slices. Oppositely, DEX did neither affect the gene expression profile of CYP3A28 nor the CYP3A activity tested in cattle liver slices.5. The data reported here are a further contribution to demonstrate the usefulness of liver slices as an in vitro tool for studies on the expression and function of xenobiotic metabolizing enzymes in cattle and in other ruminant species.","palabras_clave":"CATTLE|CYTOCHROME P450|LIVER SLICES|RAT|XENOBIOTIC METABOLIZING ENZIMES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18740,"idioma_id":4,"titulo":"Novel protease inhibitor-loaded Nanoparticle-in-Microparticle Delivery System leads to a dramatic improvement of the oral pharmacokinetics in dogs","resumen":"With the advent of the Highly Active Antiretroviral Therapy, the morbidity and the mortality associatedto HIV have been considerably reduced. However, 35e40 million people bear the infection worldwide.One of the main causes of therapeutic failure is the frequent administration of several antiretrovirals thatresults in low patient compliance and treatment cessation. In this work, we have developed an innovativeNanoparticle-in-Microparticle Delivery System (NiMDS) comprised of pure drug nanocrystals ofthe potent protease inhibitor indinavir free base (used as poorly water-soluble model protease inhibitor)produced by nanoprecipitation that were encapsulated within mucoadhesive polymeric microparticles.Pure drug nanoparticles and microparticles were thoroughly characterized by diverse complementarytechniques. NiMDSs displayed an encapsulation efficiency of approximately 100% and a drug loadingcapacity of up to 43% w\/w. In addition, mucoadhesiveness assays ex vivo conducted with bovine gutshowed that film-coated microparticles were retained for more than 6 h. Finally, pharmacokineticsstudies in mongrel dogs showed a dramatic 47- and 95-fold increase of the drug oral bioavailability andhalf-life, respectively, with respect to the free unprocessed drug. These results support the outstandingperformance of this platform to reduce the dose and the frequency of administration of protease inhibitors,a crucial step to overcome the current patient-incompliant therapy.","palabras_clave":"HIV INFECTION|PROTEASE INHIBITORS|INDINAVIR FREE BASE|PURE DRUG NANOPARTICLE-IN-MICROPARTICLE DELIVERY SYSTEM|MUCOADHESION|ORAL BIOAVAILABILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18741,"idioma_id":4,"titulo":"From Occasional Consumption to Alcohol Abuse: Quantifying the Socio-economic Determinants in Argentina","resumen":"Per capita alcohol  consumption in Argentina is higher than the world and the Americas average,  being relevant in both moderate as well as abusive consumption categories. For  this reason, this study concentrates in the socio-economic determinants of  alcoholic beverages consumption, jointly analyzing different categories:  abstinence, occasional, moderate, excessive and abusive consumption. A  Generalized Ordered Logistic model is estimated with categories modelled  according to their different individual and household socio-economic and  demographic characteristics. Data come from the 2008 and 2011 National Survey  on Substance Use. Results show that most variables are statistically  significant, with differential effects, according to the category considered.  Whereas income and working hours are positively associated with all alcohol  consumption categories, education and the absence of some indicator of  unsatisfied basic needs (UBN) increase the probabilities of occasional and  moderate consumption, decreasing heavy drinking patterns. Considering the  socioeconomic status as a single index, the results are in line with these  latest findings.","palabras_clave":"Alcoholic beverages|Moderate Consumption|Episodic Excessive Drinking (EED)|Education|Income"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18742,"idioma_id":4,"titulo":"METAL-MODIFIED MESOPOROUS SILICATE (MCM-41) MATERIAL: PREPARATION, CHARACTERIZATION AND APPLICATIONS AS AN ADSORBENT","resumen":"Mesoporous silicate (MCM-41) materials, modified with Cu2+, Fe3+ or Al3+, were prepared by a hydrothermal method, and were characterized by nitrogen adsorption at 77 K, XRD, TEM, HRTEM, TPR, adsorption of pyridine as monitored by FTIR and n-butylamine titration. The degree of ordering of the mesoporous material was decreased by the presence of Cu, Fe, or Al. The added Fe or Cu gave rise to new acidic and oxidation-reduction sites, while Al resulted in new acidic sites. The hydrothermal stabilities of selected samples were studied as a function of temperature and pH. All the samples were stable in acidic and neutral media at temperatures from 303 to 363 K. Adsorption of phenol on MCM-41 at 303 K was strongly influenced by the pH, and by the modification with Cu, Fe, or Al. Phenol adsorption was particularly strong at the Al-modified material at pH 3, apparently due to the acidic character of phenol.","palabras_clave":"MCM-41|METAL MODIFICATION|AQUEOUS STABILITY|PHENOL ADSORPTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18743,"idioma_id":5,"titulo":"?Propagación de Solidago chilensis  especie nativa apta para uso en xerojardinería?.","resumen":"Solidago chilensis Meyen ?vara de oro? (Asteraceae-Astereae) es una hierba rizomatosa perenne de hojas simples.Posee atractivos racimos apanojados de capítulos amarillos con flores dimorfas (Ariza Espinar, 2005). Presenta una abundante floración durante el verano y otoño. Los rizomas pueden ser invasores de cultivos aunque no es maleza de primer orden. En condiciones naturales llama la atención la coloración de las panojas que contrasta con el verde del follaje y la uniformidad de la altura de floración (Cuesta et al., 2006).","palabras_clave":"solidago chilensis|Asteráceas|autóctonas|ornamentales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18744,"idioma_id":5,"titulo":"Kokori, un serious games. La perspectiva de los estudiantes ante una propuesta de aprendizaje innovadora","resumen":"Se presentan aquí los resultados de una experiencia de aprendizaje en la cual se propuso a los alumnos participar de un videojuego, como una actividad más en su proceso de aprender. El propósito del estudio fue indagar las razones por la cual los alumnos eligieron jugar\/no jugar así como sus creencias sobre los posibles beneficios para el aprendizaje. El análisis de los resultados se realizó poniendo el foco en los procesos motivacionales.Participaron de la experiencia alumnos que cursan el primer año del nivel superior, en carreras del área de Ciencias Biológicas. Los resultados pusieron de manifiesto que la participación en la actividad de jugar el videojuego parece haber respondido a metas extrínsecas, pero al indagar luego sobre la experiencia de aprendizaje, parecería que la misma ha generado una posterior motivación intrínseca. Jugaron para ganar un evaluativo, pero luego de haber vivido la experiencia de aprendizaje, la incorporaron como vivencia significativa y viable de replicar en otros contextos de aprendizaje. En la discusión se hace eferencia a aquellas cuestiones del entorno que podrían actuar como favorecedoras de la motivación, poniendo especial atención al diseño de las actividades académicas.","palabras_clave":"SERIOUS GAME|INNOVACIÓN|MOTIVACIÓN|APRENDIZAJE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18745,"idioma_id":5,"titulo":"Problemáticas Interniveles en la Enseñanza de las Ciencias Naturales que dificultarían las Trayectorias Escolares","resumen":"En la siguiente comunicación se presentan algunos de los resultados del Proyecto La enseñanza de las Ciencias Naturales en el tramo educativo 11 a 14 años de la educación obligatoria, en la localidad de Candelaria, Misiones desarrollado durante los años 2010-2012. El objetivo de la misma, es caracterizar las problemáticas que dificultarían las trayectorias de los estudiantes en 7º año del nivel primario y 1º año del nivel secundario.La metodología utilizada fue cualitativa con enfoque interpretativo. Los instrumentos fueron encuestas; entrevistas; observaciones de clases; análisis de material documental y talleres reflexivos.Las problemáticas identificadas que dificultarían las trayectorias escolares y el desarrollo de competencias científicas son: las propuestas curriculares jurisdiccionales, la exigencia de autonomía y autogestión de aprendizajes para primer año, escasas propuestas de enseñanza que favorezcan la alfabetización avanzada en el Área de las Ciencias Naturales, la repetición de contenidos de Biología, y la carga horaria reducida que se destina a la enseñanza de las Ciencias Naturales en el nivel primario.","palabras_clave":"Enseñanza|Ciencias Naturales|Trayectorias escolares|Articulación primaria y secundaria."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18746,"idioma_id":5,"titulo":"Linoleic acid binding properties of ovalbumin nanoparticles","resumen":"In the present work, ovalbumin (OVA) solutions (10 g\/L, 50 mM NaCl, pH 7.5) were heat-treated at 75, 80 and 85°C (namely, OVA-75, OVA-80 and OVA-85, respectively), from 0 to 25 min. OVA nanoparticles (OVAn) around 100 nm were obtained. For 3 min of heat treatment, OVAn sizes increased with temperature, but for a heating time longer than 10 min, OVA-75 showed the highest size values. OVAn surface hydrophobicity increased 6-8 folds in comparison with native OVA and wavelength blue shifts of 25-30 nm in maximum fluorescence intensity were registered. These results suggest that buried hydrophobic residues were exposed to the aqueous medium. Binding experiments with linoleic acid (LA) as polyunsatured fatty acid (PUFA) model were carried out. Firstly, binding ability of OVAn was determined from LA titration curves of intrinsic fluorescence measurements. OVA-85 at 5 min presented the highest binding ability and it was used for further binding properties studies (turbidity, particle size distribution -PSD- analysis and &#950;-Potential measurements). Turbidity measurement and PSD analysis showed that OVAn-LA nanocomplexes were formed, avoiding LA supramolecular self-assembly formation. The union of LA to OVAn surface confers them significant lower &#950;-Potential and larger size. Hence, fluorescence and &#950;-Potential results showed that LA would bind to OVAn by mean of hydrophobic interactions. Information derived from this work could be important for potential uses of OVAn for vehiculization of PUFA with applications in several industrial sectors (food, pharmaceutical, cosmetics, etc.).","palabras_clave":"OVALBUMIN|NANOPARTICLES|PUFAS|CARRIERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18747,"idioma_id":4,"titulo":"Determination of fracture toughness J on fiber-metal laminate type CARALL  with sheets of aluminium 6061","resumen":"La determinación de  la tenacidad a la fractura en materiales compuestos híbridos, laminados  fibra-metal, FML (Fiber Metal Laminates) resulta muy importante para poder  realizar un análisis de integridad estructural que permita estimar la  tolerancia al daño y la resistencia remanente del material frente a la  propagación de una fisura. Dicha evaluación debe realizarse tanto en  estructuras aeronáuticas como navales que utilizan compuestos FML del tipo  CARALL (CArbon Reinforced Aluminum Laminates). En este trabajo se presenta la determinación  experimental de la tenacidad a la fractura en términos de los parámetros J y  CTOD utilizando probetas compactas  C(T) en un material compuesto laminado 5\/4 con láminas de aluminio 6061-O y  fibras de carbono NCT-301 embebidas en resina epoxy. Los resultados indican que  la adaptación de las técnicas de ensayo de tenacidad&nbsp; a la fractura elasto-plástica utilizadas son  aceptables para la determinación de la tenacidad J en compuestos del tipo CARALL. También se efectúa un análisis de  las superficies de fractura utilizando técnicas de microscopía óptica y SEM lo  que ha que permitido observar la forma de propagación de la fisura, el puenteo  de fibra así como del proceso de delaminación y roturas de fibras, mecanismo  principal de la fractura en estos materiales. ","palabras_clave":"COMPUESTOS|CARALL|FRACTOMECANICA|ENSAYO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18748,"idioma_id":4,"titulo":"Natural Durability and Apparent Specific Weights of Acrocarpus fraxinifolius Wight & Arn (Pink cedar) Cultivated in the Province of Misiones, Argentina.","resumen":"The objectives of this study were to explore the natural durability of heartwood and sapwood facing the action of the fungusLaetiporus sulphureus BAFC: 205, and also to determinetheapparent specific weightsof twelve years old Acrocarpusfraxinifolius Wight & Arn tree woods (Pink cedar), grown in Misiones, Argentina. The selected trees werefelledand sectionedintologs, then sawed into strips from which the samples were obtained in order to carry out the durability testing following themodified European Norm No 113, and the apparent specific weight using theIRAM Argentine Norm No.9544. The resultsshowed that heartwood is non-resistant, sapwood is perishable, and also according to the apparent specific weight it must beclassified as half-heavy wood.We conclude that the A. fraxinifolius wood can be used mainly for interior constructions and forfurniture.","palabras_clave":"ACROCARPUS FRAXINIFOLIUS|LAETIPORUS SULPHUREUS|DURAMEN|ALBURA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18749,"idioma_id":5,"titulo":"Estudio de la Pureza Óptica del Citronelal presente en la Citronela y el Eucalipto Citriodora del Noreste Argentino Usando un Método Simple","resumen":"El objetivo del trabajo fue conocer la pureza óptica del citronelal presente en los aceites esenciales de citronela (Cymbopogon nardus (L.) Rendle) y eucalipto citriodora (Eucalyptus citriodora Hook), midiendo larotación óptica específica. Los aceites esenciales se extrajeron por destilación por arrastre con vapor de agua a partir de variedades botánicas autenticadas. El citronelal, de ambos aceites esenciales fue separadopor destilación fraccionada al vacío y el de Eucalyptus citriodora debió luego purificarse químicamente antes de realizar la medición de la rotación óptica específica. La identificación de los componentes de losaceites esenciales y la cuantificación del citronelal se realizaron por cromatografía gaseosa. La rotación óptica específica se determinó utilizando la Norma IRAM-SAIPA Nº18507-2002. En este estudio se obtuvoaproximadamente 95% de (+)-citronelal a partir de citronela, mientras que el citronelal del eucalipto citriodora es prácticamente racémico, lo cual está acuerdo con información de la literatura","palabras_clave":"CITRONELAL|MEZCLA RACEMICA|PUREZA OPTICA|CYMBOPOGON NARDUS (L) RENDLE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18750,"idioma_id":4,"titulo":"Ga and In promoters in bimetallic Pt based catalysts to improve the performance in the selective hydrogenation of citral","resumen":"In this paper, bimetallic PtGa and PtIn catalysts supported on multiwall carbon nanotubes and carbon Vulcan were used to study the hydrogenation of citral (&#945;,&#946;-unsaturated aldehyde) in liquid phase to produce nerol and geraniol (unsaturated alcohols, UA). The catalysts were prepared with different metallic loadings by conventional impregnation. All the catalysts contained a Pt loading of 5 wt%. Once reduced under hydrogen flow, the supported catalysts were characterized by test reactions of the metallic phase, H2 chemisorption, temperature programmed reduction (TPR), X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). Hydrogenation results showed that the addition of a second metal to Pt leads to important modifications of the selectivity to UA. The highest selectivities to UA were reached with different promoter\/Pt atomic ratios for Ga and In. The catalyst performances in the citral hydrogenation were related to the characteristics of each supported bimetallic phase. It was found that the PtGa catalysts have a typical behavior of an ionic promoter together with a contribution of the Ga reduced species, reaching high selectivities to UA. On the other hand, PtIn catalysts with a metallic phase composed mainly by zerovalent In species in contact with the metallic phase, also showed high activities and selectivities to UA. The best selectivity value to UA (about 97%) was found for PtIn(2.5 wt%)\/CN-P catalyst with an excellent activity.","palabras_clave":"MULTIWALL CARBON NANOTUBES|CARBON VULCAN XC-72|BIMETALLIC CATALYSTS|METALLIC PHASE CHARACTERIZATION|CITRAL HYDROGENATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18751,"idioma_id":5,"titulo":"Habilidades sociales en adolescentes. El estilo agresivo de vinculación","resumen":"El objetivo de este trabajo es argumentar  el valor de las habilidades sociales en el logro del bienestar personal del  adolescente y como recurso de inclusión en su grupo de referencia. Se  conceptualiza el estilo agresivo de vinculación como una disfunción cada vez  más frecuente en la consulta psicológica.            Se definen las habilidades sociales,  se detallan las  características, las  funciones que cumplen en la adolescencia y los estilos de las mismas.  Se enfatiza en el estilo agresivo y se  desarrolla el estado actual de algunas teorías explicativas.             Una precisa definición de los  constructos hará posible el diseño de instrumentos de evaluación, paso  imprescindible para posteriores intervenciones cuyo objetivo sea promover un  cambio saludable en el estilo de vinculación del adolescente.  ","palabras_clave":"HABILIDADES SOCIALES|ADOLESCENTES|AGRESIVIDAD|INCLUSION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18752,"idioma_id":4,"titulo":"The oil consumption chia (salvia hispanica) improvement alterations haematological generated by a rich diet cholesterol","resumen":"The aim of this study was to evaluate the effect of consuming chia oil (rich in &#969;3 fatty acids) in the morphological alterations and the fatty acid composition and membrane fluidity of an animal model of hypercholesterolemia caused by a diet high in cholesterol. The rabbits were divided into 4 groups: 1) Fed with control diet (CD), 2) DC supplemented with 1% cholesterol (DH), 3) DC added with chia oil 10% (DC-CH), 4) DH chia oil added with 10% (DH-CH) for 6 weeks. After this period blood was taken and analyzed for plasma triglycerides (TG) and cholesterol (TC, LDL, HDL). Erythrocyte membranes were removed and fatty acids were measured by gas chromatography and membrane fluidity by fluorescence polarization. The blood smear and leukocyte formula was performed. The chia oil decreased TG levels (mg \/ dl) (DH: 222.3 ± 32.6 vs DH-CH: 91.7 ± 14) and the presence of acanthocytes (2% vs 10.15%), echinocytes (23% vs 60.55%) and anisocytosis (55.6% vs 83.16%) in rabbits with DH. Also not characteristic of DH rouleaux were observed. Adding chia oil decreased the fluorescence polarization (DH: 0.385 ± 0.033 vs DH-CH: 0.305 ± 0,01vs DCH: 0.301 ± 0.008) and% saturated fatty acids (SFA) in erythrocyte membranes (DH: 70 vs DH-CH: 57 vs DC: 56) and increased the% of unsaturated fatty acids (UFA) (DC: 38 and DH-CH: 40 vs DH: 27) decreasing the SFA \/ UFA in DC: 1.5 and DH-CH: 1.6vs DH: 2.6 and atherogenic index (AI) in DC: 0.82 and DH-CH: 0.83 vs DH: 1.78. In conclusion, the addition of chia oil protects erythrocytes of deleterious changes induced by hypercholesterolemia increasing membrane fluidity by incorporating UFA to it. This improves the morphology of erythrocytes.","palabras_clave":"OIL|CHIA|ALTERATIONS | HAEMATOLOGICAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18753,"idioma_id":4,"titulo":"Metabolic, haematological and liver   alterations associated with fat diets","resumen":"A diet rich in fats (DG) produces alterations in plasma lipids profile with risk of cardiovascular disease. The aim of this work was to evaluate in young rabbits the effect of consumption of a DG with cholesterol added for a short period of time on cardiometabolic risk factors and their relation to hematologic and hepatic abnormalities. Male rabbits were fed: balanced food (DC), 2-enriched 1% cholesterol (DH), 3-enriched fat to 18% (DG), 4-enriched 18% fat and 1% cholesterol (DG-H) for 6 weeks. Tolerance test pre and post the glucose feed was performed, the animals were sacrificed, blood was drawn and the liver and the visceral fat were weighed. Total cholesterol (TC), HDL, LDL, TG, blood smears and leukocyte formula was performed. Increasing TC levels (mg \/ dl) (DH: 872±114, DG-H: 1016±240 vs DC: DH 59± 5.6) was observed; LDL (DH: 666±92, DG-H: 836±244 vs DC: 23.8±3.2) in DH and DG-H while TG increased all DG (DG-H: 641±371; DG: 182±57, DH: 222± 33 vs DC: 105.7±32.4). Was generated intolerance to glucose (mg \/ dl) in DG y DG-H (DG: 0´ pre 118±7.65 vs post 126.7±11; 60´: pre 172±12 vs post 208±13; 120´: pre 142±7 vs post 172±6 and DG-H: 0´: pre 127±4 vs post 136±4; 60´ pre 181±9 vs post 251±34; 120´ pre 153±7 vs post 184±9). DG-H: neutrophil increase was observed in 50%; DH: 38%; DG: 35% vs DC: 23.4%; lymphocytes decreased DG-H: 47% vs DC: 79.67%. Blood smears revealed alterations in the morphology of erythrocytes with increased echinocytes (%) in DH: 60.5; DG: 47.2 and DG-H: 26 vs DC: 3 and anisocytosis. The liver weight \/ body weight ratio increased in rabbits fed DH: 4.62±0.36; DG-H: 4.59±0.31; DG: 5.12±1 vs DC: 3.19±0.14 and had a close correlation with plasma TG: r = 0.99 in DG-H. Visceral fat \/ body weight ratio increased DG: 0.65±0.48 and DG-H: 0.43±0.06 vs DH: 0.11±0.003 and DC: 0.39±0.22. In conclusion, we observed that both DG and DG- H diet generated increased cardiometabolic risk factors accompanied by increased numbers of neutrophils, hepatomegaly, and alterations in the morphology of erythrocytes.","palabras_clave":"METABOLIC|HAEMATOLOGICAL|FAT DIETS|ALTERATIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18754,"idioma_id":4,"titulo":"Changing epidemiology of Hepatitis C Virus genotypes in the central region of Argentina","resumen":"The aim of this study was to analyze the prevalence of hepatitis C virus (HCV) genotypes in Córdoba province, Argentina, over a 12-year period and to study the changes at the molecular level. The HCV genotype was determined in 357 HCV-infected patients, and the phylogeny and demographic reconstruction for HCV-1 was assessed. A significant reduction in HCV-2 prevalence with respect to HCV-1 in Córdoba after 2003 was observed. These findings are consistent with the epidemiological changes observed in South America. Nevertheless, the consequences of these changes remain to be elucidated.","palabras_clave":"HCV|Epidemiology|Argentina|Genotypes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18755,"idioma_id":4,"titulo":"St. Louis Encephalitis virus mosquito vectors dynamics in three different environments in relation to remotely sensed environmental conditions","resumen":"tIn Argentina the St. Louis Encephalitis virus (SLEV) is an endemic and widely distributed pathogen trans-mitted by the cosmopolitan mosquito Culex quinquefasciatus. During two outbreaks in Córdoba city, in2005 and 2010, Culex interfor was also found infected, but its role as vector of SLEV is poorly known.This mosquito species is distributed from central Argentina to southern Brazil. The primary aim of thisstudy was to analyze the population dynamic of Cx. interfor and Cx. quinquefasciatus in three differentenvironments (urban, suburban and non-urban) in relation to remotely sensed environmental data forvegetation (NDVI and NDWI) and temperature (brightness temperature). Cx. quinquefasciatus and Cx.interfor were found at the three sampled sites, being both the most abundant Culex species, with peaks inearly and midsummer. Temporal distribution patterns of both mosquito species were highly correlatedin a non-urban area of high SLEV risk transmission. Cx. quinquefasciatus and Cx. interfor were associatedwith the most urbanized site and the non-urban environment, respectively; high significant correlationswere detected between vegetation indices and abundance of both mosquito species confirming theseassociations. These data provide a foundation for building density maps of these two SLEV mosquitovectors using remotely sensed data to help inform vector control programs.","palabras_clave":"St. Louis Encephalitis virus|mosquitoes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18756,"idioma_id":4,"titulo":"Toxicology of Organochlorines: Implications of Presence in Breast Milk","resumen":"Background: Organochlorine pesticides (OCPs) are compounds that have been widely used in  agriculture to control pests and also in the field of public health to control of paludism dissemination  and other vectors. Currently, they are banned in most countries because they constitute a great  threat to human health and ecosystems. The high affinity for adipose tissue and its slow  metabolism place OCPs in the group of bioacumulative substances. Hence, OCPs passage into  breast milk is high and involves a severe risk for infants.  Objective: Analyze the toxicity including toxicodynamic and toxicokinetic of organochlorine (OC)  and evaluate perinatal and infant toxicity after its exposure through breast milk.  Methods: A desk top systematic literature research was carried out to explore the toxicity of OCPs.  We conducted an extensive literature review using databases such as Web of Knowledge, Google  search engine, Science Direct, Medline, Scopus, Lilacs databases and involved observational studies on low-dose exposure in humans.  Results: 1) OCPs constitute a real threat to ecosystems and public health. 2) They are  concentrated in breast milk and breastfeeding contributes to worsen this exposure during the  lactation period. 3) They have severe effects on CNS and the immune system, inducing  mutagenesis, carcinogenesis, teratogenesis, metabolic and reproductive abnormalities 3) The  human fetus and infant exposure to OCPs cause learning disabilities, low intelligence quotient,  attention deficit and hyperactivity.  Conclusions: For children, the best way to determine the risk of OC exposure is the analysis of  breast milk samples and milk producing animals.","palabras_clave":"Organochlorine pesticides|toxicodynamic  |toxicokinetics|toxicity|breastfeeding"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18757,"idioma_id":5,"titulo":"Políticas institucionales de inclusión universitaria, dinámicas de expansión y cambios en la composición social de los estudiantes de educación superior en la Argentina","resumen":"En las últimas cuatro décadas, la expansión de la educación superior en América Latina constituye una poderosa tendencia que, con diferentes ritmos, abarca al conjunto de los países de la región. El Informe Educación Superior en Iberoamérica 2011, elaborado por el Centro Interuniversitario de Desarrollo (CINDA), da cuenta claramente de este notable crecimiento que se manifiesta en el pasaje de apenas 1.9 millones de estudiantes en 1970 a 8.4 millones en 1990, y cerca de 25 millones en 2011, los cuales se distribuyen en 4.000 universidades y cerca de 12.000 instituciones no universitarias de educación superior. Siguiendo la tradicional clasificación de Martín Trow (2005), podemos decir que la educación superior en la región ha dejado atrás la etapa de sistemas de élite (menos del 15 % de tasa de escolarización) para ubicarse en el tránsito desde el sistemas de masas (entre 15 y 80 %) hacia la universalización de este nivel (más del 80 %).  En particular, en el caso de la Argentina, con el retorno de la democracia y la eliminación de las restricciones al ingreso en 1983, las universidades recuperaron su tendencia histórica a la expansión matricular, que en los primeros años se manifiesta como una verdadera explosión del ingreso, al incrementarse la matrícula en un 30 % Suasnábar y Rovelli, 2011). En las siguientes dos décadas, el aumento se sostiene a tasas más o menos similares, para entrar en los últimos años en una meseta. Este proceso de ampliación del acceso se refleja en las tasas de escolarización universitaria (neta y bruta) que para el año 2011 alcanzan 37,8 % y 19,6 % respectivamente, mientras que la tasa bruta de escolarización superior se eleva al 52,6 % (Anuario de Estadísticas Universitarias, 2011) .  Planteada de esta manera, la presente investigación se propone tres líneas de indagación: la primera focaliza su interés en el análisis de las dinámicas de expansión reciente de la educación superior y su vinculación los patrones históricos de desarrollo educativo, que como fue señalado, supone explorar las relaciones entre educación universitaria y terciaria por un lado, y entre las dinámicas de expansión del nivel medio y las formas que asume la expansión del nivel superior, por el otro. La segunda línea de indagación se orienta al análisis de los cambios en la composición social de la matrícula de educación superior operados en la última década (2003-2013) con especial énfasis en la caracterización del perfil socio-económico y cultural de la población estudiantil de los sectores populares que acceden a este nivel de enseñanza. Y por último, plantea una tercera línea centrada en el relevamiento, análisis y caracterización de las políticas institucionales de inclusión educativa desarrolladas por las universidades nacionales, que posibilite la construcción de un mapa nacional de los diferentes programas, proyectos y acciones orientadas al mejoramiento del acceso, permanencia y graduación de los","palabras_clave":"INCLUSION|EXPANSIÓN|DISPOSITIVOS|UNIVERSIDADES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18758,"idioma_id":4,"titulo":"Ocular biocompatibility of Polyquaternium 10 gel: functional and morphological results","resumen":"This work deals with the characterization study of the topical and intraocular biocompatibility, security and toxicity of the cationic hydroxyethylcelluloses polyquaternium 10 (PQ10). We also evaluate the rheological properties of gels.The cytotoxicity assays were done in two cell lines: HEp-2 and VERO (human larynx epidermoid carcinoma cell and African green monkey kidney cells respectively) and for the in vivo study, New Zealand albino rabbits were used. The in-vitro cytotoxic activity of PQ10 shows no statistically significant differences with the control in any of the cell lines used in this study. Similarly, the signs of inflammation observed after treatment showed no significant difference between the problem group compared to controls. Normal histological characteristic were seen in both groups with no histological inflammatory reaction. After one month of the intracameral application of PQ10 at 2 % (treatment group) or 0,3% hydroxypropylmethylcellulose (HPMC)(control group), electroretinograms (ERGs) showed similar levels of a- and b-waves latencies and amplitude.In summary, PQ10 gel was well tolerated in these experiments, with proper monitoring could stand as a new alternative in the development of ophthalmic viscosurgical devices.","palabras_clave":"BIOPOLYMERS |CATIONIC CELLULOSE|OPHTHALMIC VISCOSURGICAL DEVICES|OPTHALMIC HIDROGELS|RETINAL DAMAGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18759,"idioma_id":4,"titulo":"Biochemical Characterization of Gm1 Micelles-Amphotericin B Interaction","resumen":"In this work a thorough characterization of the GM1 micelle-Amphotericin B (AmB) interaction was performed. The micelle formation as well as the drug loading occurs spontaneously, although influenced by the physicochemical conditions, pH and temperature. The chromatographic profile of GM1-AmB complexes at different molar ratios shows the existence of two populations. The differential absorbance of GM1, monomeric and aggregate AmB, allowed us to discriminate the presence  of all of them in both fractions. Thus, we noted that at higher proportion of AmB in the complex, increases the larger population which is composed mainly of aggregated AmB. The physical behavior of these micelles shows that both GM1-AmB complexes were stable in solution for at least 30 days. However upon freeze-thawing or lyophilization-solubilization cycles, only the smallest population, enriched in monomeric AmB, showed a complete solubilization. In vitro, GM1-AmB  micelles were significantly less toxic on cultured cells than other commercial micellar formulations as Fungizone, but had a similar behavior to liposomal formulations as Ambisome. Regarding the antifungal activity of the new formulation, it was very similar to that of other formulations. The characterization of these GM1-AmB complexes is discussed as a potential new formulation able to improve the antifungal therapeutic efficiency of AmB.","palabras_clave":"AGGREGATION-STATES|AMPHOTERICIN|DRUG-DELIVERY|GANGLIOSIDES|MICELLES|PHYSICOCHEMICAL CHARACTERIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18760,"idioma_id":4,"titulo":"Application of k-means Clustering, Linear Discriminant Analysis and Multivariate Linear Regression for the development of a predictive QSAR model on 5-lipoxygenase inhibitors","resumen":"n this work, we performed a quantitative structure activity relationship (QSAR) model for a family of 5-lipoxygenase (5-LOX) inhibitors using k-means clustering and linear discriminant analysis (LDA) for the selection of training and test sets and multivariate linear regression (MLR) for the independent variable selection. With the k-means clustering method, the total set of compounds (58 derivatives of 5-Benzylidene-2-phenylthiazolinones) was divided in two clusters according to a simple discriminant function. We found that piID (conventional bond order ID number) molecular descriptor discriminates correctly 100% of the compounds of each clusters. Thirty different models divided in three series were analyzed and the series with representative training and test sets (series 3) had the most predictive models. The statistical parameters of the best model are Rtrain = 0.811 and Rtest = 0.801. We found that a rational selection in the setting-up of training and test sets allows to obtain the most predictive models and the random selection is sometimes unsuitable, especially, when the total set of compounds can be classified in different clusters according to structural features.","palabras_clave":"QSAR|5-LIPOXYGENASE INHIBITORS|k-MEANS CLUSTERING|LINEAR DISCRIMINANT ANALYSIS|MULTIVARIATE LINEAR REGRESSION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18761,"idioma_id":4,"titulo":"QSAR and 3D-QSAR studies applied to compounds with anticonvulsant activity. A Review","resumen":"Introduction: Quantitative structure?activity relationships (QSAR and 3D-QSAR) have been applied in the last decade to obtain a reliable statistical model for the prediction of the anticonvulsant activities of new chemical entities. However, despite the large amount of information on QSAR, no recent review has published and discussed this data in detail.    Areas covered: In this review, the authors provide a detailed discussion of QSAR studies that have been applied to compounds with anticonvulsant activity published between the years 2003 and 2013. They also evaluate the mathematical approaches and the main software used to develop the QSAR and 3D-QSAR model.    Expert opinion: QSAR methodologies continue to attract the attention of researchers and provide valuable information for the development of new potentially active compounds including those with anticonvulsant activity. This has been helped in part by improvements in the size and performance of computers; the development of specific software and the development of novel molecular descriptors, which have given rise to new and more predictive QSAR models. The extensive development of descriptors, and the way by which descriptor values are derived, have allowed the evolution of the QSAR methods. This evolution could strengthen the QSAR methods as an important tool in research and development of new and more potent anticonvulsant agents.","palabras_clave":"ANTICONVULSANT ACTIVITY|QSAR|3D-QSAR|REVIEW"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18762,"idioma_id":4,"titulo":"The mathematics teacher s profession: the perspective of future","resumen":"We present partial results of the design and implementation of a study program for the Mathematics Teacher Training. The research is developed in the light of the Anthropological Theory of the Didactic. This paper we analyze what gestures of the research and world questioning pedagogy are identified in a group of future teachers that study an essential issue to the mathematics teacher profession: how to teach mathematical knowledge? The work was carried out with futures mathematics teachers of the third year of a careen university in Argentina. The main results indicate that the future teachers, at the beginning of the study program, do not seem to carry out the distinctive didactics gestures of the research and questioning the world pedagogy.","palabras_clave":"Teacher training|Anthropological Theory of the Didactic|Research and Study Path|Mathematics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18763,"idioma_id":4,"titulo":"Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line. Impact on sorafenib cytotoxicity","resumen":"Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide. Sorafenib isthe only drug available that improves the overall survival of HCC patients. P-glycoprotein(P-gp), Multidrug resistance-associated proteins 2 and 3 (MRP2 and 3) and Breast cancerresistance protein (BCRP) are efflux pumps that play a key role in cancer chemoresistance.Their modulation by dietary compounds may affect the intracellular accumulation and therapeuticefficacy of drugs that are substrates of these transporters. Genistein (GNT) is a phytoestrogenabundant in soybean that exerts its genomic effects through Estrogen-Receptors and Pregnane-X-Receptor (PXR), which are involved in the regulation of theabove-mentioned transporters. We evaluated the effect of GNT on the expression and activityof P-gp, MRP2, MRP3 and BCRP in HCC-derived HepG2 cells. GNT (at 1.0 and 10 &#956;M)increased P-gp and MRP2 protein expression and activity, correlating well with an increasedresistance to sorafenib cytotoxicity as detected by the methylthiazole tetrazolium(MTT) assay. GNT induced P-gp and MRP2 mRNA expression at 10 but not at 1.0 &#956;M concentrationsuggesting a different pattern of regulation depending on the concentration. Inductionof both transporters by 1.0 &#956;M GNT was prevented by cycloheximide, suggestingtranslational regulation. Downregulation of expression of the miR-379 by GNT could be associatedwith translational regulation of MRP2. Silencing of PXR abolished P-gp inductionby GNT (at 1.0 and 10 &#956;M) and MRP2 induction by GNT (only at 10 &#956;M), suggesting partialmediation of GNT effects by PXR. Taken together, the data suggest the possibility of nutrient-drug interactions leading to enhanced chemoresistance in HCC when GNT is ingestedwith soy rich diets or dietary supplements.","palabras_clave":"mrp2|sorafenib|hepg2|higado"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18765,"idioma_id":4,"titulo":"Anthocyanins as markers for the classification of Argentinean wines according to botanical and geographical origin. Chemometric modeling of liquid chromatography?mass spectrometry data","resumen":"A study of Argentinean red wines was performed by direct injection of untreated wine samples into aliquid chromatography?mass spectrometry system, processing the collected data with two chemometricalgorithms: multivariate curve resolution with alternating least-squares and discriminant unfolded partialleast-squares (D-UPLS). The objectives were: (1) the chemometric resolution of profiles in the modesrepresented by elution time and m\/z ratio, (2) the discrimination of samples according to varietal and\/orgeographical origin, and (3) the identification of key compounds helping to perform sample discrimination.The results indicate that all wine varietals can be adequately discriminated, and also three wineproducing regions (located in the east, south and north of the Cuyo region) were differentiated fromthe remaining regions. The applied chemometric models allowed the tentative identification of anthocyanincompounds as responsible for both type of discriminations, in the case of D-UPLS by employing theconcept of variables importance in the projection.","palabras_clave":"LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY|MULTIVARIATE CURVE RESOLUTION|DISCRIMINANT PARTIAL LEAST-SQUARES|WINE DISCRIMINATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18766,"idioma_id":5,"titulo":"MANIFESTACIONES BUCALES Y CUTANEAS DEL PENFIGO VULGAR","resumen":"El Pénfigo Vulgar es una patología de etiología autoinmune, que se caracteriza por la formación y aparición de ampollas que se rompen y dejan erosiones muy dolorosas tanto en las mucosas bucales como en zonas cutáneas de distintas partes del cuerpo y en especial en zonas de roce.  Se presenta en forma progresiva con fases de brote y exacerbación y de remisión muy dolorosas que desestabiliza a los pacientes que la padecen.  Es una enfermedad muy difícil de curar y de controlar y puede llevar a la muerte al paciente si no se lo controla.","palabras_clave":"PENFIGO|BUCAL|CUTANEO|MANIFESTACIONES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18767,"idioma_id":5,"titulo":"Estrategia de Detección de Fallas de Circuito Abierto en Semiconductores de Convertidores CC-CC Aislados","resumen":"En este trabajo se analiza la operación de un convertidor CC-CC cuando uno de los semiconductores de potencia presenta una condición de falla de circuito abierto. Se propone una nueva estrategia de diagnóstico de falla, la cual consiste en medir la caída de tensión a bornes de cada uno de los semiconductores de potencia utilizando la información disponible en los circuitos de activación. La tensión medida se compara con un valor de referencia para determinar si un semiconductor presenta una condición de circuito abierto. Esta estrategia tiene la ventaja de que puede llevarse a cabo sin incluir sensores adicionales. Se incluyen resultados experimentales para validar la teoría.","palabras_clave":"CONVERTIDOR CC-CC|PUENTES DUALES ACTIVOS|DIAGNÓSTICO|FALLAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18768,"idioma_id":4,"titulo":"Chlorine initiated photooxidation of (CH3)3CC(O)H in the presence of NO2 and photolysis at 254 nm. Synthesis and thermal stability of (CH3)3CC(O)OONO2","resumen":"zzzzzzz","palabras_clave":"Atmósfera|Peroxinitratos|Estabilidad térmica|(CH3)3CC(O)OONO2|(CH3)3CC(O)H"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18769,"idioma_id":4,"titulo":"Mycotoxin profile of Fusarium armeniacum isolated from natural grasses intended for cattle feed","resumen":"AbstractFusarium armeniacum has been found as a saprophyte on natural grasses devoted to cattle feed in Argentina. This species has been reported as highly toxigenic due to the production of trichothecenes type A, but the information available about its toxigenic profile is incomplete. Thus, the aim of the present study was to determine the toxigenic ability of 50 F. armeniacum isolates recovered from natural grasses using a multitoxin method based on LC-MS\/MS. In addition, morphological identification of 15 selected isolates was confirmed by sequencing the translation elongation factor 1&#945;. Out of the 327 metabolites analysed, only 10 were detected: T-2 toxin (T-2), T-2 triol, T-2 tetraol, HT-2 toxin (HT-2), diacetoxyscirpenol (DAS), monoacetoxyscirpenol (MAS), neosolaniol (NEO), aurofusarin (AUF), beauvericin (BEA) and zearalenone (ZEA). The most common group of mycotoxins produced by the isolates on rice under laboratory conditions was trichothecenes type A, and some minor Fusarium mycotoxins, such as BEA and AUF. Some isolates were also able to produce ZEA. Among the trichothecene type A, HT-2, T-2, NEO were clearly synthesised at the highest levels and frequency, followed by DAS and MAS. HT-2, T-2, NEO and DAS production was detected in 48 (96%), 47 (94%), 47 (94%) and 38 (76%) isolates, respectively. The ability of F. armeniacum, to produce ZEA and AUF has been demonstrated here for the first time. Given the new information provided about the toxigenic profile of this species, commonly associated with natural grasses in Argentina, the threat to animal health posed by this fungus should not be underestimated.","palabras_clave":"FUSARIUM|CATTLE FEED|MYCOTOXINS|TRICHOTHECENES TYPE A|ZEARELENONE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18770,"idioma_id":4,"titulo":"Role of 3 Lipoprotein Lipase Variants in Triglycerides in Children Receiving Highly Active Antiretroviral Therapy","resumen":"BACKGROUND: Lipoprotein lipase is a key enzyme in lipid metabolism, especially for plasma triglycerides (TGs). Genetic variants have been associated with lipid levels in healthy individuals, cardiovascular disease, obesity and diabetes. Our aim was to evaluate the influence of 3 polymorphisms: Hind III, Pvu II and S447X in plasma TG levels in human immunodeficiency virus-1-infected children under highly active antiretroviral therapy (HAART).METHODS: Fifty-two children diagnosed with human immunodeficiency virus-1 between 2005 and 2009 were retrospectively selected with at least 1 plasma TG level assessment. TG levels were examined before and after 1 year of HAART. Hypertriglyceridemia was defined as TG &gt; 150 mg\/dL. Hind III (H+\/H-), Pvu II (P+\/P-) and S447X (S\/X) were determined by polymerase chain reaction and restricted fragment length polymorphism. The Wilcoxon sum-rank test was used to compare median plasma TG among groups. Also, allelic frequencies were estimated for these variants in an Argentinean population.RESULTS: Allelic frequencies for human immunodeficiency virus-1-infected children were: H-, 0.21; P-, 0.53; and X, 0.05 with no significant differences to controls. After 1 year of HAART, median TG levels were significantly lower in P-\/P- (98.5 mg\/dL) when compared with P+\/P+ (180 mg\/dL) (P = 0.039). The presence of the P- allele was associated with an 11-fold lower risk of hypertriglyceridemia. Hind III and S447X were not associated with TG at the selected time points.CONCLUSIONS: Our findings suggest a protective effect of lipoprotein lipase polymorphisms against hypertriglyceridemia in children after 1 year of HAART. These results could endorse a prompt nutritional or pharmacological intervention in patients lacking the P- allele.","palabras_clave":"lipoprotein lipase|triglycerides|highly active antiretroviral therapy|children|human immunodeficiency virus-1 infection"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18771,"idioma_id":4,"titulo":"Mannose-binding lectin gene as a modifier of the cystic fibrosis phenotype in Argentinean pediatric patients","resumen":"Background:There is a considerable variation in the phenotype and course of the disease in cystic fibrosis (CF) even in patients with the same CFTR genotype, suggesting that other factors are important for prognosis. Mannose-binding lectin (MBL) has been proposed as one of these factors. We therefore investigated the influence of MBL2 gene variants on disease severity, age at acquisition of Pseudomonas aeruginosa, and survival in CF patients.Methods:MBL2 variants were studied in 106 Argentinean pediatric CF patients carrying two severe CFTR mutations. Clinical phenotype was defined according to the Shwachman score and lung function tests. Age at infection with P. aeruginosa and age at death were also recorded.Results: MBL insufficiency was associated with a 3.5-fold risk of having a severe phenotype (CI 95%: 1.2-10.3, p=0.03). It was also associated with an earlier onset of infection with P. aeruginosa (p=0.035). No statistically significant differences were found in FEV1 and survival.Conclusions: MBL insufficiency was associated with detrimental progression of the disease. These results together with previous findings suggest that the effect of MBL2 expression may be a major determinant of the severity of the clinical phenotype in patients with CF.","palabras_clave":"MBL|Fibrosis Quística|Pediatría"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18772,"idioma_id":4,"titulo":"Emergence of novel A\/G recombinant HIV-1 strains in Argentina","resumen":"The predominant circulating HIV-1 strains in South America are subtype B and B\/F recombinants with different distribution among countries. However, the emergence of other subtypes is a matter of concern and needs continuous monitoring. We identified three different A\/G recombinants in Argentina, two of them in vertically infected children from unlinked mothers and one in an adult female. HIV-1 pol sequences from the children showed novel A\/G recombination patterns and no phylogenetic relationship with previously reported South American A\/G sequences. The third A\/G recombinant was a CRF06_cpx with African origin. The detection of new or unusual subtypes is important to avoid false negative PCR HIV-1 early diagnosis due to detection failures and for future vaccine development.","palabras_clave":"HIV|epidemiología|evolución viral|diversidad"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18773,"idioma_id":5,"titulo":"El Banco Mundial  y tres décadas de reformas educacionales en América Latina","resumen":"El artículo estudia el papel del Banco Mundial en educación, en América Latina, entre 1980 y 2013. Se realiza una síntesis de los diagnósticos y recomendaciones del Banco a partir de la lectura de los documentos más relevantes del período. Hemos delimitado dos grandes etapas: una que, iniciada a fines de los 80, cobra fuerza a partir de la Conferencia Mundial sobre Educación para Todos, celebrada en 1990 en Jomtien y se extiende hasta fines de la década del 90. En ese periodo se desarrollan los principales planteos del organismo que orientaron las reformas de los sistemas educativos en la región. En la segunda desde 2000 a la actualidad- el Banco revisa algunas de las recomendaciones previas, en virtud de las críticas y de los nuevos desafíos que identifica a partir de sus lecciones aprendidas. Finalmente, analizamos la presencia del Banco en las políticas educacionales de México y Argentina a través de la consideración de los proyectos implementados con financiamiento del organismo.","palabras_clave":"BANCO MUNDIAL|REFORMA|EDUCACION|AMÉRICA LATINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18774,"idioma_id":5,"titulo":"El género en la relación entre clase social y estilo de vida: una mirada a través del tiempo libre","resumen":"El trabajo que aquí se presenta tiene como pregunta central ¿Cómo incide el género en la relación entre clase social y la práctica de actividades de tiempo libre ? Como principales resultados  puede decirse que la clase social incide en las diferentes actividades de tiempo libre, particularmente los períodos  vacacionales más extensos, en consumos más elevados de Internet y en la concurrencia al cine. Las mujeres de clase intermedia y más aún las de clase obrera realizan menos actividades de tiempo libre, afectadas las últimas también por la demanda de cuidado de los hogares a los que pertenecen. En tanto que  los varones obreros  en hogares con requerimientos de cuidado alto, también efectúan menos actividades de tiempo libre que los de otras clases sociales.","palabras_clave":"GENERO|CLASE SOCIAL|ESTILO DE VIDA|TIEMPO LIBRE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18775,"idioma_id":4,"titulo":"Transesterification of vinyl acetate with i-amyl alcohol catalyzed by nanostructured sulfated zirconia","resumen":"Due to enviromental concerns, it is highly desirable to replace liquid HF or SO4H2 by more benign solid acid such as sulfated zirconia (SZ). Sulfated zirconia materials have been demostrated to be a good catalyst for the isomerization of lineal alcanes at relatively low temperatures. Our objetive was:(1st)prepre nanostructurated materials either by controlled hydrolysis of zirconium alcoxide or by impregnation of tetragonal zirconia with H2SO4 1 M or ammonium sulfate, (2nd) carry out the characterization by conventional techniques (X ray diffraction, electron microscopy, N2 absorption, FT-IR spectroscopy, UV diffuse reflectance) and (3nd) evaluate the acidity through the transesterification reaction of vinyl acetate with i-amyl alcohol to give i-amyl acetate and acetaldehyde and using toluene as solvent.","palabras_clave":"SULFATED ZIRCONIA|SOLID ACIDS|FTIR-RAMAN SPECTROSCOPY|TRANSESTERIFICATION|VINYL ACETATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18776,"idioma_id":4,"titulo":"Rapid Synthesis of Nanometric Cellulose Hydroxyapatite","resumen":"Cellulose hydroxiapatite (Cel-Hap) nanometrics were prepared by microwave-assisted method in order to improve structural and morphological characteristics. The preparation of nanometric Cel-Hap was performed using different grades of cellulose (pharmaceutical aid and analytical reagent), CaCl2.4H2O and NaH2PO4.2H2O precursors. The mixture was heated in a microwave oven at low temperature (70ºC and 90ºC) for five minutes. This method is applied in order to reduce synthesis time as well as to obtain materials more efficient to remove pollutants ions. The solids were characterized by Electronic Spectroscopy (DRUV),X-ray diffraction, Vibrational Spectroscopy (FTIR,Raman) and SEM. FTIR and Raman spectra show the characteristic bands of carbonated hydroxyapatite and cellulose. X-ray diffraction shows the typical diffraction peacks of HAp and cellulose. SEM shows moephological differences between obtained solids: spicular (CelA-HAp, analytical reagent) and stacked layers (Cel1-HAp, pharmaceutical aid) respectively. From the SEM studies and applying Scherrer`s formula the materials were found to be nanometrics.","palabras_clave":"HYDROXIAPATITE|CELLULOSE SYNTHESIS|NANOMATERIALS|MICROWAVE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18777,"idioma_id":5,"titulo":"Determinación de la altura de la cobertura nubosa mediante visión estereoscópica digital","resumen":"Dentro de los parámetros que caracterizan a una nube, la altura de su base es un factor dominante en la  determinación de las propiedades radiativas infrarrojas de la misma y por lo tanto un parámetro fundamental a  cuantificar. Por ello, en el presente trabajo se desarrolló una metodología para la determinación de la altura de la  cobertura nubosa (Cloud Base Height: CBH). La misma consta de 3 etapas principales: 1. La caracterización del  sensor de cada cámara en laboratorio a través de un banco de calibración óptico; 2. Un procedimiento de  posicionamiento de las cámaras en el exterior para su correcta alineación y estabilización; 3. Un algoritmo de  procesamiento digital de imágenes en lenguaje MATLAB, el cual a partir de dos imágenes simultaneas estima la  CBH aplicando el principio de visión estereoscópica en distintos puntos de interés. Las mediciones obtenidas del  sistema, compuesto por un par de cámaras digitales emplazadas una distancia conocida entre sí (100m), fueron  contrastadas con un lidar para su validación. Analizando dos casos principales, uno con nubosidad alta  (8000~12000 m) y otro con múltiples capas de nubosidad baja (800~4000 m), se determinó para el primer caso  una incertidumbre máxima de altura de base de nubes menor al 38% y para el segundo caso una incertidumbre  máxima menor al 10%. Se pudo determinar que las principales fuentes de incerteza en esta metodología están  asociadas con factores provenientes de la caracterización de las cámaras y su alineación con la vertical en el  exterior del sistema. Los resultados de esta metodología aportan una herramienta alternativa para la  determinación de la CBH, constituyéndose en un sistema de relativo bajo costo con respecto a los ceilómetros  comerciales.","palabras_clave":"nubes|visión estereo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18778,"idioma_id":4,"titulo":"Experimental evidence of biological interactions among different isolates of Trypanosoma cruzi from the Chaco Region","resumen":"Many infectious diseases arise from co-infections or re-infections with   more than one genotype of the same pathogen. These mixed infections   could alter host fitness, the severity of symptoms, success in pathogen   transmission and the epidemiology of the disease. Trypanosoma cruzi,   the etiological agent of Chagas disease, exhibits a high biological   variability often correlated with its genetic diversity. Here, we   developed an experimental approach in order to evaluate biological   interaction between three T. cruzi   isolates belonging to different Discrete Typing Units (DTUs TcIII, TcV   and TcVI). These isolates were obtained from a restricted geographical   area in the Chaco Region. Different mixed infections involving   combinations of two isolates (TcIII + TcV, TcIII + TcVI and TcV + TcVI)   were studied in a mouse model. The parameters evaluated were number of   parasites circulating in peripheral blood, histopathology and genetic   characterization of each DTU in different tissues by DNA hybridization   probes. We found a predominance of TcVI isolate in blood and tissues   respect to TcIII and TcV; and a decrease of the inflammatory response in   heart when the damage of mice infected with TcVI and TcIII + TcVI   mixture were compared. In addition, simultaneous presence of two   isolates in the same tissue was not detected. Our results show that   biological interactions between isolates with different biological   behaviors lead to changes in their biological properties. The occurrence   of interactions among different genotypes of T. cruzi observed in our mouse model suggests that these phenomena could also occur in natural cycles in the Chaco Region.","palabras_clave":"BIOLOGICAL PROPERTIES|CHAGAS DISEASE|ISOLATES|INTERACTIOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18779,"idioma_id":4,"titulo":"Trypanosoma cruzi diversity in the Gran Chaco: Mixed infections and differential host distribution of TcV and TcVI","resumen":"The transmission cycles of Trypanosoma cruzi in the Gran Chaco are complex networks involving domestic and wild components, whose interrelationships are not well understood. Knowing the circuit of transmission of the different Discrete Typing Units (DTUs) of T. cruzi in the complex environment of the Chaco region is relevant to understanding how the different components (reservoirs, vectors, ecotopes) interact. In the present study we identified the DTUs infecting humans and dogs in two rural areas of the Gran Chaco in Argentina, using molecular methods which avoid parasite culture. Blood samples of humans and dogs were typified by PCR-DNA blotting and hybridization assays with five specific DNA probes (TcI, TcII, TcIII, TcV and TcVI). PCR analyses were performed on seropositive human and dog samples and showed the presence of T. cruzi DNA in 41.7% (98\/235) and 53% (35\/66) samples, respectively. The identification of infective DTUs was determined in 83.6% (82\/98) and 91.4% (32\/35) in human and dog samples, respectively. Single infections (36.7% - 36\/98) and a previously not detected high proportion of mixed infections (47.9% - 47\/98) were found. In a 15.3% (15\/98) of samples the infecting DTU was not identified. Among the single infections TcV was the most prevalent DTU (30.6% - 30\/98) in human samples; while TcVI (42.8% - 15\/35) showed the highest prevalence in dog samples. TcV\/TcVI was the most prevalent mixed infection in humans (32.6% - 32\/98); and TcI\/TcVI (14.3% - 5\/35) in dogs. Significant associations between TcV with humans and TcVI with dogs were detected. For the first time, the presence of TcIII was detected in humans from this region. The occurrence of one human infected whit TcIII (a principally wild DTU) could be suggested the emergence of this, in domestic cycles in the Gran Chaco.","palabras_clave":"ARGENTINA|DOMESTIC CYCLE|HYBRIDIZATION|PCR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18780,"idioma_id":4,"titulo":"Nuclear acridine orange fluorescence in Rhizoctonia isolates from rice","resumen":"This is the first time this methodology  has been applied to observe nuclei in cells of Rhizoctonia isolates  obtained from rice cultivars from Corrientes province,  Argentina.","palabras_clave":"NUCLEI IN CELLS|ORYZA SATIVA|RHIZOCTONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18781,"idioma_id":4,"titulo":"Association Between Methylation of SHP-1 Isoform I and SSTR2A Promoter Regions with Breast and Prostate Carcinoma Development","resumen":"Methylation pattern is presented here for first time as a potential molecular marker of changes on SSTR2A and SHP-1(I) gene promoter related to breast and prostate carcinoma. Our results have shown low concordances with SSTR2A and methylated state in prostate cancer andmoderate relationship with unmethylated CpG-27 in breast cancer.We found significant concordances for both cancers and SHP-1(I) unmethylation, and increased HER2 expression and SSTR2A methylation in breast cancer. Moreover, we found a correlation between methylation patterns of two genes in normal breast tissue. These datamight assist to select subgroups of patients for the administration of alternative therapies.","palabras_clave":"Prostate Cancer|Breast Cancer|Methylation Pattern|SSTR2 and SHP-1"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18782,"idioma_id":5,"titulo":"Animales ponzoñosos en La Pampa","resumen":"s\/r","palabras_clave":"ponzoñosos|accidentes|epidemiología"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18783,"idioma_id":4,"titulo":"Bio-inoculation of yerba mate seedlings (Ilex paraguariensis St. Hil.) with native plant growth promoting rhizobacteria: a sustainable alternative to improve crop yield","resumen":"In this study, the role of native plant growthpromoting rhizobacteria (PGPR) as bio-inoculants was assessed as an alternative to ameliorateIlex paraguariensis  St. Hill. growth in nursery comparing poorer (soil) versus richer (compost) substrates. Twelve rhizospheric strains isolated from yerba mate plantations were evaluated in vitro for their potential as PGPRs. Three isolates, identified as Kosakonia radicincitansYD4,Rhizobium pusenseYP3, and Pseudomonas putidaYP2, were selected on the basis of their N2fixation activity, IAA-like compound and siderophore production, and phosphate solubilization. A highly significant positive effect of bio-inoculation with the native isolates was observed in 5-month-old seedlings cultivated in soil. The highest increase was observed in seedlings inoculated with K. radicincitansYD4 with an increase of 183 % in the dry shoot weight and a 30 % increase in shoot N content. In contrast, in compost, no increment in the dry weight was observed; however, an increase in content in some macronutrients in shoots was observed. Remarkably, when plant biomass was compared between soil and compost, seedlings inoculated withK. radicincitansYD4 in soil produced the highest yields,even though higher yields could be expected in compost due to the richness of this substrate. In conclusion, bio-inoculation of yerba mate seedlings with native PGPR increases the yield of this crop in nursery and could represent a promising sustainable strategy to improve yerba mate growth in low-fertility soils","palabras_clave":"SOIL|MICROORGANIMS|YERBA MATE|BIOFERTILIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18784,"idioma_id":4,"titulo":"Genome Sequence of Kosakonia radicincitans Strain   YD4, a Plant Growth-Promoting Rhizobacterium Isolated from Yerba Mate (Ilex   paraguariensis St. Hill)","resumen":"Kosakonia radicincitansstrain YD4 is a rhizospheric isolate from yerba mate (Ilex paraguariensisSt. Hill.) with plant growthpromoting effects on this crop. Genes involved in different plant growth-promoting activities are present in this genome, suggesting its potential as a bioinoculant for yerba mate","palabras_clave":"genoma|rizobacter|ilex paraguariensis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18785,"idioma_id":4,"titulo":"Permutation min-entropy: An improved quantifier for unveiling subtle temporal correlations","resumen":"The aim of this letter is to introduce the permutation min-entropy as an improved symbolic tool for identifying the existence of hidden temporal correlations in time series. On the one hand, analytical results obtained for the fractional Brownian motion stochastic model theoretically support this hypothesis. On the other hand, analysis of several computer generated and experimentally observed time series illustrate that the proposed symbolic quantifier is a versatile and practical tool for identifying the presence of subtle temporal structures in complex dynamical systems. Comparisons against the results obtained with other tools confirm its usefulness as an alternative and\/or complementary measure of temporal correlations.","palabras_clave":"TIME SERIES ANALYSIS|ENTROPY|COMPLEX SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18786,"idioma_id":4,"titulo":"First report of Papaya ringspot virus W infecting Momordica charantia in Cuba","resumen":"During a survey conducted in July 2010, severe mosaic and  deformations were observed on the leaves of cerasee (Momordica  charantia) in Villa Clara, Cuba. The symptoms resembled  those induced by Papaya ringspot virus (PRSV) in papaya  (Carica papaya L.) plants (Olarte et al., 2011). Leaf samples were  ELISA positive when tested with a specific PRSV antiserum  (Agdia, USA). The presence of PRSV was confirmed by the  amplification of a 850 bp fragment by RT-PCR using primers  specific to the PRSV coat protein gene (unpublished information).  BLASTn analysis of the sequences from the RT-PCR amplified  product (GenBank accession No. KP019380) showed  94% identity with PRSV-W isolates from Citrullus lanatus in  the USA (GenBank accession Nos. JN132439 to JN132457)  and PRSV-P isolates (GenBank accession Nos. AF196839 and  EF189736). Crude sap extracts from symptomatic M. charantia  leaf samples were mechanically inoculated onto Cucurbita  moschata and papaya plants. Symptoms developed in the former  but not in the latter plants, suggesting the presence of  PRSV-W, since only PRSV-P is able to infect papaya plants  (Romay et al., 2014). In inoculated plants, the presence of this  virus was determined by ELISA. In Cuba, the first molecular  detection of PRSV-W was from Cucurbita pepo (Rodríguez-  Martínez, personal communication) and PRSV-P has only  been reported in papaya plants (Portal et al., 2006). To our  knowledge, this is the first report of PRSV-W infecting M.  charantia in Cuba. This finding is relevant for the epidemiology,  and management of this disease in cucurbits.","palabras_clave":"PAPAYA RINGSPOT VIRUS|MOMORDICA CHARANTIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18787,"idioma_id":4,"titulo":"H II Region G46.5-0.2: The Interplay between Ionizing Radiation, Molecular Gas, and Star Formation","resumen":"                    H ii regions are particularly interesting because they can generate dense layers of gas and dust, elongated columns or pillars of gas pointing toward the ionizing sources, and cometary globules of dense gas where triggered star formation can occur. Understanding the interplay between the ionizing radiation and the dense surrounding gas is very important to explain the origin of these peculiar structures, and hence to characterize triggered star formation. G46.5-0.2 (G46), a poorly studied galactic H ii region located at about 4 kpc, is an excellent target for performing this kind of study. Using public molecular data extracted from the Galactic Ring Survey (13CO J = 1?0) and from the James Clerk Maxwell Telescope data archive (12CO, 13CO, C18O J = 3?2, HCO+, and HCN J = 4?3), and infrared data from the GLIMPSE and MIPSGAL surveys, we perform a complete study of G46, its molecular environment, and the young stellar objects (YSOs) placed around it. We found that G46, probably excited by an O7V star, is located close to the edge of the GRSMC G046.34-00.21 molecular cloud. It presents a horse-shoe morphology opening in the direction of the cloud. We observed a filamentary structure in the molecular gas likely related to G46 and not considerable molecular emission toward its open border. We found that about 10' to the southwest of G46 there are some pillar-like features, shining at 8 &#956;m and pointing toward the H ii region open border. We propose that the pillar-like features were carved and sculpted by the ionizing flux from G46. We found several YSOs likely embedded in the molecular cloud grouped in two main concentrations: one, closer to the G46 open border consisting of Class II type sources, and another mostly composed of Class I type YSOs located just ahead of the pillar-like features, strongly suggesting an age gradient in the YSO distribution.                    ","palabras_clave":"HII REGIONS|ISM: CLOUDS|ISM: MOLECULES|STARS: FORMATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18788,"idioma_id":4,"titulo":"Glare by Light Emitting Diode (LED) vehicle traffic signals","resumen":"In this paper we analyze devices for traffic signals (traffic lights) with LED technology. The traditional measurements of luminous intensity were complemented with the luminance analysis of the devices, evaluated for diverse angular fields. The obtained results show a significant increase in the punctual luminance, for values of global emission comparable to those obtained in conventional devices. This effect together with the relatively high degree of coherence of the color lights could result in new kinds of glares not considered in the current standards.","palabras_clave":"Led|Vision|Color"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18789,"idioma_id":5,"titulo":"El Conservatorio Nacional de 1888: La Primera Fundación","resumen":"El Conservatorio Nacional de 1888 constituye un hito en la enseñanza musical argentina. Sin embargo, tal acontecimiento ha sido ignorado, desvirtuado  y desnaturalizado en la bibliografía. Los distintos autores han confundido esta institución con otras impulsadas por Juan Gutiérrez o pretiriéndola como institución privada con subvención estatal. Esta situación puede deberse a la nula consulta, por parte de los investigadores, de las normas que sucesivamente fueron dictadas para reglar su existencia. Los decretos presidenciales de 1888 y 1890 no dan lugar, de ninguna manera, a las dudas que se verifican en la bibliografía. Tampoco sería inocente en la configuración de ese escenario la visión que tenía Alberto Williams de los fundamentos que debían guiar la enseñanza musical en la Argentina. En efecto, con la autoridad que de él emanaba, pudo sostener como paradigma, su conservatorio, modelo que ostensiblemente resultaba antagónico al que por impulso de Gutiérrez y sostén del Estado Nacional plasmaba en el Conservatorio fundado en 1888. Los investigadores que se ocuparon del tema adoptaron esa visión y consideraron, como él, a Gutiérrez un predecesor suyo y no un pionero de un paradigma que triunfaría en 1924 con la fundación del Conservatorio Nacional de Música y Declamación.","palabras_clave":"Música|Conservatorio|Enseñanza|Fundación"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18790,"idioma_id":4,"titulo":"On the photooxidation of the multifunctional drug niclosamide.  A kinetic study in the presence of vitamin B2 and visible light","resumen":"Objectves: The multifunctional drug niclosamide (NSD), extensively employed therapeutically, is a frequent pollutant of surface waters. Considering the environmental importance of photodegradative processes for this type of contaminant, the kinetic and mechanistic aspects of the possible visible-light-mediated photooxidation of NSD were studied under naturalistic conditions. Methods: The visible-light absorber riboflavin (vitamin B2) was employed as a photosensitizer. The vitamin can usually be found in natural waters and is the most common endogenous photosensitizer in mammals. The interaction of NSD with electronically excited states of Rf and with photogenerated reactive oxygen species (ROS) was evaluated through conventional UV spectroscopy, laser flash photolysis, time-resolved phosphorescence detection of singlet molecular oxygen (O2( 1 Deltag)), and polarographic dosage of dissolved oxygen. Results: Ground state NSD quenched the long-lived triplet excited state of Rf (3 Rf*) and the photogenerated ROS (O2( 1 Deltag)) and superoxide radical anion (O?&#8722; 2 ). As a result, NSD was photooxidized. The rate constants for the interaction NSD?O2( 1 Deltag) are particularly low, in the order of 106 \/M\/s, although the whole interaction is attributable to a pure reactive process. The O2( 1 Deltag) quenching was faster in alkaline medium, favored by the ionization of the NSD phenolic group. Under Rf-photosensitization, NSD was degraded very much more rapidly than phenol, the latter being considered a paradigmatic water-contaminant model compound. NSD may behave as an antioxidant in bio-environments, as demonstrated employing the photooxidizable amino acid tryptophan as a relevant biological target. Discussion: The results indicate that a O?&#8722; 2 -mediated process is the main route for the Rf-sensitized photooxidation of NSD. Photodegradation of the biocide in the presence and absence of phenol and tryptophan was quantitatively evaluated, discussed, and interpreted in terms of competitive quenching processes of 3 Rf*, O2( 1 Deltag), and O?&#8722; 2 by the substrates.","palabras_clave":"NICLOSAMIDE|PHOTODEGRADATION|PHOTOOXIDATION|REACTIVE OXYGEN SPECIES|RIBOFLAVIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18791,"idioma_id":4,"titulo":"Identification of pyroxene minerals used as black pigments in painted human bones excavated in Northern Patagonia by Raman spectroscopy and XRD","resumen":"The skeletal remains of seven individuals were excavated in a secondary burial context in the site of Cima de los Huesos, in the San Matías Gulf (Río Negro, Argentina). AMS dating of two samples for this site to 1173 ± 45 and1225 ± 47 years BP make it one of the earliest burials of its kind uncovered so far in the Patagonian region. Among the findings, the skeleton of a male painted with parallel lines alternating red and black colors was uncovered. SEM-EDS elemental analysis of microsamples removed from the red and the black pigments showed the presence of Mn and Fe as the main components, respectively. Raman microspectroscopy combined with micro-X-ray diffraction analysis showed that the red pigment contains hematite and that the black pigment is composed of members of the pyroxene mineral group, ferrosilite (FeSiO3) and enstatite (MgSiO3) along with kanoite (MnMgSi2O6). This is, to our knowledge, the first report on the use of pyroxenes as black pigments to decorate human remains or archeological artifacts in South America. No organic compounds that could have been used as binders for the paints were detected by FTIR-ATR. Contamination due to quartz and aluminosilicates, mainly microcline and albite, from the burial environment did not allow determining whether clay minerals were used in the paints as binders and\/or extenders. The multitechnique approach used was crucial to overcome the limitations of the individual techniques to firmly identify Mn-containing black pigments.","palabras_clave":"RAMAN MICROSPECTROSCOPY|MICRO X RAY DIFFRACTION|PYROXENES|PAINTED BONES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18792,"idioma_id":5,"titulo":"El rol de la envidia benigna y maligna en la toma  de decisiones estratégicas","resumen":"Este trabajo se propuso examinar la influencia de la envidia benigna y maligna en las ofertas del proponente en condición de envidiado y envidioso en el Juego del Ultimátum en 172 estudiantes universitarios de Córdoba, Argentina. Se empleó un diseño factorial intersujetos 2 (tipo de envidia: maligna y benigna) X 2 (condición del participante: envidiado y envidioso) con un grupo adicional de control absoluto. Se compararon las ofertas en el Juego del Ultimátum según la condición experimental. No se observaron diferencias estadísticamente significativas entre las distintas condiciones. Sin embargo, se observó que la preocupación por ser envidiado se relacionó positivamente con las ofertas en el Juego.","palabras_clave":"envidia maligna|envidia benigna|juego del ultimátum"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18793,"idioma_id":5,"titulo":"REI codisciplinar a la Microeconomía para el último año del nivel secundario: preguntas generatrices y derivadas","resumen":"Este trabajo presenta un Recorrido de Estudio e Investigación (REI) implementado en el último año del nivel secundario argentino (estudiantes de 17-18 años). Se presentan las preguntas generatrices del REI y las preguntas derivadas durante la implementación, que se realizó en las sesiones de clases de Matemática habituales, no extraescolares ni paralelas al curso. La duración fue de 36 sesiones de clases. Las preguntas generatrices del REI refieren a la Microeconomía, a los modelos de oferta y de demanda de un único bien.","palabras_clave":"REI|TAD|Didactica de la matematica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18794,"idioma_id":5,"titulo":"VARIACIONES GEOGRÁFICAS DE LA ESTRUCTURA Y COMPOSICIÓN DE LA VEGETACIÓN LEÑOSA EN EL LÍMITE ENTRE EL ESPINAL Y EL MONTE EN EL NORESTE DE LA PATAGONIA (ARGENTINA)","resumen":"La definición de las ecorregiones incide sobre el uso de la tierra ya que éstas son tomadas como base para la formulación de políticas de manejo y conservación. Los disturbios provocan variaciones de la vegetación entre sitios cercanos dificultando el establecimiento de límites entre regiones. Con el objetivo de analizar un gradiente geográfico en un área transicional entre el Espinal y el Monte, se caracterizaron estructura y composición de la vegetación leñosa en el noreste de la Patagonia y se evaluó en qué medida sitios cercanos con diferencias estructurales presentaban diferencias composicionales asimilables a cada ecorregión. La variación de la composición florística presentó cambios más importantes en dirección E-O que en dirección N-S, reflejando un amplio gradiente de transición Espinal-Monte. Los cambios estructurales más claros fueron la disminución de la altura y cobertura arbórea en oposición a la cobertura arbustiva. Tales cambios resultaron menos asociados con la variación geográfica que los cambios composicionales, exhibiendo mayor variación en dirección N-S y en menor medida en la dirección E-O. Los disturbios promueven cambios más notables en la estructura que en la composición florística por lo que resulta poco probable que provoquen un corrimiento de límites geográficos entre las ecorregiones Monte y Espinal.","palabras_clave":"Limite fitogeográfico|Conservación|Ecorregiones |S.O. de Buenos Aires"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18795,"idioma_id":4,"titulo":"Support for full disclosure up front","resumen":"A commentary on 'Models of Consent to Return of Incidental Findings in Genomic Research' by Paul S. Appelbaum, Erik Parens, Cameron R. Waldman, Robert Klitzman, Abby Fyer, Josue Martinez, W. Nicholson Price II, and Wendy K. Chung, in the July-August 2014 issue. 'Models of Consent to Return of Incidental Findings in Genomic Research' by Paul Appelbaum et al. (July-August 2014), presents an interesting reconstruction of four models of consent to return incidental or secondary findings. We agree with the principles they use to evaluate the models: respect for persons, beneficence, and justice, principles set down in the Belmont Report. However, when drawing conclusions from their evaluation of these models, the authors focus too little on the importance of the ethical requirement of voluntary and autonomous choice and its precondition: full comprehension of the facts and circumstances prior to consenting (as Ruth Faden and Tom Beauchamp discuss in A History and Theory of Informed Consent). In genetic counseling and whole genome data collection, we always deal with the delicate topic of racism, discrimination, and eugenics, having seen in recent history the possible consequences of neglecting to respect individuals' autonomy. Genetic data, especially, demands an extensive information process prior to consenting, as it is linked to very personal, predictive, and determinative data.","palabras_clave":"WHOLE GENOME SEQUENCING|INFORMED CONSENT|INCIDENTAL FINDINGS|MODELS OF INFORMED CONSENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18796,"idioma_id":5,"titulo":"Comunicación y Gestión de Intangibles. Análisis de intangibles, imagen corporativa y sistemas de comunicación en MIPYMES del Conurbano Sur del Gran Buenos Aires","resumen":"El siguiente artículo tiene como objetivo conocer cuáles son las estrategias de las MIPymes del Conurbano Sur del Gran Buenos Aires para dar a conocer su marca en busca de potenciales clientes. Conocer cuáles son las herramientas, tanto del marketing como de la publicidad, utilizadas para promover sus productos y\/o servicios.  Se trabajó con una selección aleatoria no probabilística de 72 Microemprendimientos radicados en los partidos del Conurbano Sur del Gran Buenos Aires identificados dentro del ?Programa Capital Semilla?, de la SEPYME del año 2011.  Se podrá conocer con más precisión las necesidades y dificultades comunicacionales presentadas en las MIPYMES. Esto permitirá generar nuevas propuestas integrales para un sector emergente en la sociedad.","palabras_clave":"MIPYMES|COMUNICACION|ESTRATEGIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18797,"idioma_id":5,"titulo":"ENSAYOS EN LABORATORIO PARA EL CONTROL DE FLORACIONES ALGALES MEDIANTE ULTRASONIDO","resumen":"El mayor desarrollo de Cyanobacteriagenerado por la eutroficación de ambientes acuáticos produce, además deafloramientos y compuestos con olores y sabores desagradables, liberación demetabolitos tóxicos. El desarrollo excesivo de algas también es problema paraaguas que se pueden utilizar para consumo humano o procesos industriales, peroel tratamiento para su eliminación lleva a aumentos de los costosoperativos.&nbsp; En este trabajo se analizala utilización en laboratorio del ultrasonido como alternativa viable paracontrolar el desarrollo de algas, en particular de Cyanobacteria. Los resultados obtenidos (utilizando una frecuenciade 20 kHz y una potencia de 9 W) muestran que los organismospertenecientes a las Clases Chrysophyceae,Euglenophyceae y Chlorophyceae fueron eliminados a los5 minutos de exposición, y Raphidiopsismediterranea dentro de los primeros 10 minutos, en tanto que, luego de 60minutos, la reducción fue del 98% para M. aeruginosa y del 99% para Dolichospermum spiroides.","palabras_clave":"CALIDAD DE AGUAS|ULTRASONIDO|MICROALGAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18798,"idioma_id":4,"titulo":"In situ conservation of the wild relative of the common bean (Phaseolus vulgaris var. aborigineus) at the south of its neotropical distribution: environmental characterization of a population in central Argentina","resumen":"The common bean (Phaseolus vulgaris L.) is a food of worldwide vital importance. Like any crop, the conservation of its wild relatives is essential to maintain the genetic variability needed for plant breeding. In situ conservation of such population has the additional benefit of generating new variations through the evolution of its natural environment. In 2004, wild populations of P. vulgaris var. aborigineus were found in the province of Córdoba (Argentina), being the southernmost specimen of its current distribution. In order to study the state and characterize the environment of such populations, vegetation censuses were conducted along a stretch of the Tanti stream-arroyo Tanti-(Punilla, Córdoba). Results showed that the wild bean has an intermediate to high constancy throughout the watercourse and its presence decreases upstream and away from the stream. Most cover took place in plots with scarce slope, high incidence of light and intense magnitude of floods. Vegetation develops in an environment surrounded by forests, meadows and intermediate physiognomy. Besides adventitious species, the studied area still has native species of high conservation value. Based on the analysis of this work, and considering the biogeographical significance of this population of wild bean, we conclude that this stretch of the studied stream is a priority area for the in situ conservation of P. vulgaris var. aborigineus.","palabras_clave":"common bean (Phaseolus vulgaris L.)|neotropical distribution|characterization of a population in central Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18799,"idioma_id":5,"titulo":"BIOLOGIA REPRODUCTIVA Y COMPORTAMIENTOS DE CUIDADO PARENTAL DE DOS ESPECIES DE ATAJACAMINOS DE CÓRDOBA, ARGENTINA","resumen":"Los atajacaminos son aves insectívoras cuya coloración mimética y actividad nocturna los hace difícil de estudiar. El objetivo de este estudio fue describir aspectos poco conocidos de la biología reproductiva del Atajacaminos Chico (Setopagis parvulus parvulus) y el Atajacaminos Ñañarca (Systelluralongirostris patagonicus), dos especies comunes y simpátricas del Chaco Serrano en la provincia de Córdoba, Argentina. Observamos gran similitud en cuanto al nido y sitio de nidificación de las especies estudiadas, así como en caracteres reproductivos y comportamientos de cuidado parental. El tamaño denidada de ambas especies fue de dos huevos, y la incubación (monitoreada con sensores de temperatura y observaciones directas) estuvo a cargo principalmente de las hembras, mientras que los machos colaboraron en dicha tarea durante algunas horas del día. El período de incubación duró aproximadamente17 días y el porcentaje de atención al nido fue elevado en ambas especies (A. Chico incubó 92,81± 2,33% y A. Ñañarca incubó 92,39 ± 4,73% del día). No se documentó traslocación de huevos en ningún nido, pero se observaron desplazamientos de los pichones desde el nido a distancias que aumentaronprogresivamente a medida que los pichones aumentaban de edad. En ambas especies las curvas de crecimiento de pichones indicaron una diferencia de tamaño entre los pichones del mismo nido, posiblemente asociada a la eclosión asincrónica. Este estudio contribuye al conocimiento de las estrategias de historias de vida y comportamientos reproductivos de caprimúlgidos del Neotrópico, el cual hasta el momento es limitado y merece mayor atención.","palabras_clave":"incubation, parental care, reproduction, |Little Nightjar|Band-winged Nightjar"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18800,"idioma_id":4,"titulo":"Decrease in lactobacilli in the intestinal microbiota of celiac children with a gluten-free diet, and selection of potentially probiotic strains","resumen":"Abstract:The intestinal microbiota would be implicated in pathology associated withceliac disease caused by an abnormal immune system reaction against glutenpresent in cereal grains. The objectives of this work were to detect throughbasic methods the changes in the composition of the most common genera ofbacteria from the intestinal microbiota of symptom-free celiac disease childrenwith a gluten-free diet compared with healthy children from Tucumán and toselect lactobacilli (Lb)strains with probiotic potential from the feces ofhealthy children. Results demonstrated that the feces of celiac childrenwith&nbsp; a gluten-free diet showedsignificantly lower counts of Lb (P &lt; 0.05) compared with healthy children,while enterobacteria tended to increase in celiac children. On the basis ofthese results, isolation of some Lb from the feces of healthy children wascarried out. Thus, 5 Lb strains were selected because of their high resistancepercentages to gastrointestinal tract conditions. In addition, theirautoaggregation and hydrophobicity properties were evaluated: lactobacillusrhamnosus (LC4) showed the highest percentage of autoaggregation whileLactobacillus paracasei (LC9) showed high hydrophobicity. Based on theseresults, LC4 and LC9 were selected, and their use as potential probioticstrains to improve signs and symptoms associated with celiac disease isdiscussed. This is the first study performed in Argentina concerning therelationship between intestinal microbiota and celiac disease in celiacchildren with a gluten-free diet. In addition, the development of a probioticfood addressed towards celiac patients and designed with Lb isolated from thefeces of healthy children from our province represents a promising alternativeto improve the quality of life of celiac patients.  ","palabras_clave":"CELIAC DESEASE|LACTOBACILLUS|MICROBIOTA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18801,"idioma_id":4,"titulo":"Water Resources Management with Dynamic Optimization Strategies and Integrated Models of Lakes and Artificial Wetlands","resumen":"In this work, we propose an integrated mechanistic model for a freshwater eutrophic reservoir and an artificial wetland and within a dynamic optimization framework. A partial differential equation system results from dynamic mass balances for the main phytoplankton groups; two zooplankton groups and two size classes of zooplanktivorous fish in the reservoir, as well as dissolved oxygen and main nutrients in both the reservoir and wetland. Algebraic equations stand for forcing functions profiles, such as temperature, solar radiation, river inflows and concentrations, etc. The model is formulated as an optimal control problem within a control vector parameterization approach in gPROMS. Optimization variables are the fraction of nutrient rich water stream that is derived through the wetland and fish removal rates from the reservoir. The objective function is the minimization of a weighted sum of integrals along the entire time horizon: the quadratic difference between phytoplankton concentration and a desired value below eutrophication limits and the quadratic difference between phosphate concentration in the wetland outflows and a desired value. Numerical results provide optimal profiles for restoration actions and their effects on the studied ecosystem.","palabras_clave":"OPTIMAL CONTROL PROBLEM|EUTROPHICATION|RESTORATION|BIOMANIPULATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18802,"idioma_id":4,"titulo":"Simultaneous parameters identifiability and estimation of an E. coli metabolic network model","resumen":"This work proposes a procedure for simultaneous parameters identifiability and estimation in metabolic networks in order to overcome difficulties associated with lack of experimental data and large number of parameters, a common scenario in the modeling of such systems. As case study, the complex real problem of parameters identifiability of the Escherichia coli K-12 W3110 dynamic model was investigated, composed by 18 differential ordinary equations and 35 kinetic rates, containing 125 parameters. With the procedure, model fit was improved for most of the measured metabolites, achieving 58 parameters estimated, including 5 unknown initial conditions. The results indicate that simultaneous parameters identifiability and estimation approach in metabolic networks is appealing, since model fit to the most of measured metabolites was possible even when important measures of intracellular metabolites and good initial estimates of parameters are not available.","palabras_clave":"PARAMETER IDENTIFIABILITY|PARAMETER ESTIMATION|METABOLIC NETWORKS|ESCHERICHIA COLI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18803,"idioma_id":4,"titulo":"Male and female meiosis in the mountain scorpion Zabius fuscus (Scorpiones, Buthidae): Heterochromatin, rDNA and TTAGG telomeric repeats","resumen":"Allcytogenetically studied scorpions present male achiasmatic meiosis and lackheteromorphic sex chromosomes. In contrast, information about female meiosis inscorpions is scarce due to the difficulty of finding meiotic cells. The genusZabius includes three described species and no chromosome studies have been performedon it until now. We analyzed the constitutive heterochromatin distribution,NORs and telomeric sequences in mitosis and meiosis of males and females of differentpopulations of Zabius fuscus. All specimens presented 2n = 18 holokineticchromosomes that gradually decreased in size. Male meiosis presented ninebivalents and a polymorphism for one reciprocal translocation in one population.Telomeric signals were detected at every terminal region, confirming also thepresence of a (TTAGG)n motif in Buthidae. Constitutive heterochromatin wasfound in three chromosome pairs at a terminal region; moreover, NORs wereembedded in the heterochromatic region of the largest pair. Chromosome size andlandmarks allowed us topropose the chromosomes involved in the rearrangement. Infour females, cells at different prophase I stages were analyzed. We describe adiffuse stage and the presence of ring-shaped bivalents. We discuss thepossible origin of these bivalents in the framework of chiasmatic orachiasmatic female meiosis. These results contribute to increase the scarceevidence of female meiosis in scorpions and raise new questions about itsmechanism. ","palabras_clave":"HOLOKINETIC CHROMOSOMES|ACHIASMATIC MEIOSIS|FISH|FEMALE DIFFUSE STAGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18804,"idioma_id":5,"titulo":"MODELOS DE COMPORTAMIENTO  COMO MARCO DE ANALISIS DEL OBJETIVO EMPRESARIO","resumen":"El trabajo examina los distintos modelos de comportamiento, definidos por J. Pfeffer, y traza relaciones con la definición de objetivo empresario, en términos de la maximización del valor a largo plazo del capital propio.Los modelos de comportamiento económico, social, moral, racional retrospectivo y cognitivo, aportan cada uno elementos de análisis particulares y complementarios. Atravesando visiones de comportamiento racional y mercados sin fricciones, hasta aquellas que incorporan cuestiones morales y efectos de mecanismos perceptivos ? cognitivos, se rescatan elementos que son de utilidad para tomar decisiones y estructurar sistemas de metas congruentes con la definición del objetivo de la gestión empresarial. Se concluye que la definición de objetivo empresario en términos del valor de largo plazo del capital propio no precisa reformulación, en tanto unidad de medida y parámetro para establecer méritos relativos. Se reconoce que los aportes de las teorías críticas y de los modelos de comportamiento son fundamentales para lograr la necesaria orientación de largo plazo de la gestión. La última parte del trabajo relaciona el objetivo empresario y las teorías del comportamiento, desde el terreno de la práctica de la gestión.","palabras_clave":"OBJETIVO EMPRESARIO|MODELOS DE COMPORTAMIENTO|VALOR EMPRESA|STAKEHOLDERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18805,"idioma_id":4,"titulo":"Public Transport Priority for Multimodal Urban Traffic Control","resumen":"Abstract: In order to improve the travel time of surface public transport vehicles (bus, tramway, etc.), several cities use Urban Traffic Control  (UTC)systems enabling to give priority to public transport. This paper reviews these systems.   Further on after a debate on their insufficiencies in the global regulation of the urban traffic on a whole network, the paper proposes intermodal regulation   strategies, operating on intersection trafficlights to regulate the traffic, favouring the public transport. All these strategies are based on the Linear Quadratic (LQ) optimal control theory, but they are different in their ways of taking into account the public transport in the optimization problem. The simulation tests are carried out in a network of eight intersections and two public transport lines.","palabras_clave":"OPTIMIZATION|TRAFFIC CONTROL|LINEAR QUADRATIC|BUS PRIORITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18806,"idioma_id":5,"titulo":"Especies prevalentes de nemátodes gastrointestinales en ovinos en el sur de las provincia de Córdoba , Argentina","resumen":"Se muestrearon un total de 18 establecimientos ovinos con el objetivo de determinar la prevalencia de nemátodos gastrointestinales. Estableciéndose que los géneros Haemonchus y Teladorsagia fueron los predominantes.","palabras_clave":"ovinos|relevamiento|nematodos gastrointestinales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18807,"idioma_id":4,"titulo":"Promoted ceria catalysts for alkyne semi-hydrogenation","resumen":"CeO2 is a highly selective catalyst for the partial hydrogenation of alkynes. However, due to its limited H2 splitting ability, a high operating temperature is required for the reaction, hampering the practical exploitation of this abundant oxide. In this work, we demonstrate that gallium promotes the activity of CeO2 for the semi-hydrogenation of acetylene and methylacetylene, enabling a reduction of the operating temperature to 373 K, while maintaining an outstanding ethylene and propylene selectivity (80?97%), even in the presence of excess alkene in the feed. Oligomers comprised the main secondary product, while the selectivity to the corresponding alkane did not exceed 2%. The characterization of mixed Ce-Ga oxides reveals that the progressive incorporation of gallium into the ceria structure, forming a solid solution, boosts the oxygen storage capacity and the reducibility of the material. This is ascribed to the facilitated H2 activation on the Ga-promoted samples, as confirmed by in situ infrared spectroscopy and density functional theory simulations. The interplay between the advantage brought by the decreased barrier for H2 cleavage and the disadvantage due to the increased number of oxygen vacancies governs the reactivity of the CeGaOx catalysts in alkyne hydrogenation. The composition in the optimal catalyst, containing a molar Ce:Ga ratio of 95:5, was extrapolated to other trivalent cations. Indium incorporated in theceria lattice favored the low-temperature H2 activation and led to an activity enhancement that surpassed that of gallium. However, aluminum did not form a solid solution with ceria and caused no effect. This work comprises the first application of promoted cerias in hydrogenation catalysis and may prompt further developments in olefin purification.","palabras_clave":"Alkyne hydrogenation|Olefin production|Promoted ceria|H2 activation|Gallium|Indium"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18808,"idioma_id":4,"titulo":"Molecular Structure and Thermal Stability of Oxide-Supported Phosphotungstic Wells-Dawson Heteropolyacid","resumen":"We present, for the first time in the literature, a systematic study of the molecular structure of the Wells? Dawson heteropolyacid H6P2W18O62.24H2O (HPA) dispersed on TiO2, SiO2, ZrO2 and Al2O3. The heteropolyacidbased materials were synthesized through a conventional impregnation method (in aqueous and ethanol media) at a loading that corresponds to the theoretical ??monolayer?? coverage (dispersion limit loading). The combination of Raman and infrared studies demonstrates the presence of crystals of HPA (regardless of the nature of the medium used during the synthesis) suggesting that the dispersion limit loading was greatly exceeded. In situ temperature programmed spectroscopy analyses demonstrated that the Raman shift of the distinctive WQO Raman mode of the phosphotungstic Wells?Dawson heteropolyacid is sensitive to the local environment, that is, the amount of water molecules associated with the structure. Moreover, the aqueous based species associated with such structures are recognizable through infrared spectroscopy","palabras_clave":"supported HPA|FTIR|Raman|dioxonium"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18809,"idioma_id":4,"titulo":"Effects of surface topography on the collective diffusion of interacting adsorbed particles","resumen":"Collective diffusion of particles with repulsive nearest-neighbor interactions on bivariatesurfaces is studied through Monte Carlo simulation, in the framework of the Kubo?Greentheory. Shallow and deep adsorbing sites form l × l patches distributed at random or inchessboard-like ordered domains on a two-dimensional square lattice. The influence ofthe energetic correlation and the lateral interactions on the jump and collective diffusioncoefficients are analyzed by simulating the coverage fluctuations in the grand canonicalensemble and the mean-square displacements of particles in the canonical ensemble. Thecombination of topography and lateral coupling is shown to produce interesting effectssuch as different filling regimes as well as strong effects on the coverage dependence of thetransport coefficients.","palabras_clave":"Difussion|Adsorption|Heterogeneous surface|Monte Carlo simulations"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18810,"idioma_id":5,"titulo":"Caracterización de naranjo 'Valencia late' sobre diferentes portainjertos en Entre Ríos, Argentina","resumen":"El uso de portainjertos es una estrategiade producción en cultivos frutales, orientada a controlarfactores como porte de la planta, resistencia a plagas yenfermedades, precocidad en el ingreso a producción.Este trabajo tuvo como objetivos: evaluar el tamaño, laproducción y la eficiencia productiva de plantas de naranjo?Valencia Late? [Citrus sinensis (L.) Osbeck] sobre diferentesportainjertos, clasificarlos y determinar cuáles inducenplantas más eficientes para la región. La información decampo se obtuvo entre las campañas 1994 y 2010, en ensayosde naranjo ?Valencia Late? injertado sobre 17 portainjertosdiferentes, con 333 plantas por hectárea, en 'Entre Ríos',Argentina. Se registró la producción, se midieron variablesde crecimiento (altura de planta, diámetro de copa, diámetrode tronco por encima y por debajo del injerto) y se calculóel volumen de copa y la eficiencia productiva. Para describirel comportamiento de las variables de crecimiento y deproducción e identificar grupos de portainjerto, segúnel tamaño de las plantas, la producción y la eficienciaproductiva, se realizó Análisis de Componentes Principales,gráfico Biplot, Análisis de la Varianza Multivariado yprueba de Hotteling. Se pudieron identificar tres grupos deportainjertos; el primero incluyó plantas de mayor porte,mayor producción pero menor eficiencia productiva; elsegundo, con plantas de tamaño y productividad intermediay el tercero, con plantas de pequeño porte y mayor eficienciaproductiva. Los portainjertos del tercer grupo demostraronser más eficientes y pueden ser recomendados para la regiónen estudio con mayores densidades de plantación.","palabras_clave":"Frutales|Plantas|Producción|Eficiencia productiva"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18811,"idioma_id":4,"titulo":"'High Temperature Mechanical Behavior of Porous Cordierite-Based Ceramic Materials Evaluated Using 3-Point Bending?","resumen":"Cordierite-based ceramics are an important segment of the present ceramic industry. In the last years, cordierite-based porous ceramics have received great attention as light structural materials, thermal insulting and catalyst supports, among others. For these applications, a combination of high porosity and low weight of the component are required, together with mechanical stability even at high temperatures which might prevail in use. The combination of these requirements is a challenge due to the compromise existing among them. In this work, materials prepared from two precursor mixes of cordierite based on kaolin, talc and alumina by thermal consolidation (80 °C, 4 h) of stable aqueous suspensions mix-starch were evaluated. Two different native starches, potato and corn, were employed. The starch gel, which acted as binder in the green body, generated the pores when it was eliminated during a further thermal treatment (650 °C, 2 h). The transformation of the raw materials in cordierite was carried out by reaction-sintering at 1330 °C, 4 h. Cylindrical bars of 35-50 mm in length and 3.5-4.0 mm in diameter were prepared using this method, and then, they were mechanically tested from room temperature to 1100 °C using 3-point bending. A servohydraulic testing machine INSTRON 8501 and a SiC fixture (span: 30 mm) were used for the mechanical testing. The tests were performed in displacement control with a constant rate of 0.1 mm\/min. The difference observed in the behavior and the mechanical parameters (Young modulus and mechanical strength) of final materials were related with the characteristics of raw materials and their composition, texture and microstructure, especially porosity and the presence of glassy phase.","palabras_clave":"Mechanical Behavior|Porous Cordierite|3-Point Bending"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18812,"idioma_id":5,"titulo":"Patrimonio Geológico- Minero y Recreación en una Ciudad Intermedia: Tandil, Argentina","resumen":"El patrimonio, relacionado con la herencia, es un concepto dinámico que alude a la historia, que se enlaza con la esencia misma de la cultura y es asumido directamente por los grupos locales. Es la síntesis de los valores que dan identidad a una sociedad que los reconoce como propios. Ello implica un proceso de reconocimiento intergeneracional de unos elementos como parte del bagaje cultural y su vinculación a un sentimiento de grupo. Los lugares, convertidos hoy en espacios de destino turístico, deben sustentarse en la revalorización y refuncionalización del patrimonio en todas sus dimensiones. Esto debe vincularse a la propia comunidad, a su crecimiento, lo que implica un mejor nivel de vida y a su vez a la necesidad de un desarrollo integral que refuerce su identidad local. El objetivo del trabajo es analizar los vínculos actuales en el contexto de la oferta, entre turismo- recreación y patrimonio minero y geológico de Tandil, Argentina,  para establecer diferentes relaciones que permitan construir líneas de acción.","palabras_clave":"PATRIMONIO|MINERIA|GEOLOGIA|TURISMO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18813,"idioma_id":4,"titulo":"Novel compound heterozygous Thyroglobulin mutations c.745+1G>A\/c.7036+2T>A associated with congenital goiter and hypothyroidism in a Vietnamese family. Identification of a new cryptic 5' splice site in the exon 6.","resumen":"Several patients were identified with  dyshormonogenesis caused by mutations in the thyroglobulin (TG) gene. These defects are inherited in an  autosomal recessive manner and affected individuals are either homozygous or  compound heterozygous for the mutations. The aim of the present study was to  identify new TG mutations in a  patient of Vietnamese origin affected by congenital hypothyroidism, goiter and  low levels of serum TG. DNA  sequencing identified the presence of compound heterozygous mutations in the TG gene: the maternal mutation  consists of a novel c.745+1G&gt;A (g.IVS6 + 1G&gt;A), whereas the hypothetical  paternal mutation consists of a novel c.7036+2T&gt;A (g.IVS40 + 2T&gt;A). The  father was not available for segregation analysis. Ex-vivo splicing assays and  subsequent RT-PCR analyses were performed on mRNA isolated from the  eukaryotic-cells transfected with normal and mutant expression vectors.  Minigene analysis of the c.745+1G&gt;A mutant showed that the exon 6 is skipped  during pre-mRNA splicing or partially included by use of a cryptic 5?? splice  site located to 55 nucleotides upstream of the authentic exon 6\/intron 6 junction  site. The functional analysis of c.7036+2T&gt;A mutation showed a complete  skipping of exon 40. The theoretical consequences of splice site mutations,  predicted with the bioinformatics tool NNSplice, Fsplice, SPL, SPLM and  MaxEntScan programs were investigated and evaluated in relation with the  experimental evidence. These analyses predicted that both mutant alleles would  result in the abolition of the authentic splice donor sites. The c.745+1G&gt;A  mutation originates two putative truncated proteins of 200 and 1142 amino  acids, whereas c.7036+2T&gt;A mutation results in a putative truncated protein of  2277 amino acids. In conclusion, we show that the c.745+1G&gt;A mutation  promotes the activation of a new cryptic donor splice site in the exon 6 of the  TG gene. The functional  consequences of these mutations could be structural changes in the protein  molecule that alter the biosynthesis of thyroid hormones.","palabras_clave":"Congenital hypothyroidism|Thyroglobulin gene|Mutation|Compound heterozygous mutations|Cryptic splice site"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18814,"idioma_id":4,"titulo":"Hadron structure functions at small $ x $ from string theory","resumen":"Deep inelastic scattering of leptons from hadrons at small values of the  Bjorken parameter x is studied from superstring theory. In particular, we  focus on single-flavored scalar and vector mesons in the large N limit. This  is studied in terms of different holographic dual models with flavor Dp-branes  in type IIA and type IIB superstring theories, in the strong coupling limit of  the corresponding dual gauge theories. We derive the hadronic tensor and the  structure functions for scalar and polarized vector mesons. In particular, for  polarized vector mesons we obtain the eight structure functions at small values  of the Bjorken parameter. The main result is that we obtain new relations of  the Callan-Gross type for several structure functions. These relations have  similarities for all different Dp-brane models that we consider. This would  suggest their universal character, and therefore, it is possible that they hold  for strongly coupled QCD in the large N limit.  ","palabras_clave":"GAUGE\/STRING DUALITY|DIS|MESON STRUCTURE FUNCTIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18815,"idioma_id":5,"titulo":"'Así lo que me gusta: notas sobre la interfaz sintaxis-pragmática en el español paraguayo'","resumen":"En el presente trabajo nos centramos en un conjunto de estructuras focalizadoras propias del español paraguayo, que difieren del estándar peninsular y americano, como Así lo que me gusta o ¿Quién lo que llora? Estas construcciones tienen la intención pragmática de resaltar cierto elemento del discurso, a partir de una estrategia propia de las cláusulas hendidas, esto es, por medio de la separación de dos elementos con la forma invariable lo que. Para analizar esta construcción, contrastamos los datos del español paraguayo con distintos tipos de cláusulas (seudo) hendidas del español general (Fue Eva quien llamó \/ Eva fue quien llamó \/ Quien llamó fue Eva) y con las galicadas (Ahí es que nos vamos a reunir, Fue Juan que lo dijo). También comparamos los datos con los análogos en guaraní, lengua con la que el español paraguayo mantiene un intenso contacto debido al bilingüismo actual y a los siglos de coexistencia en la región. Para el análisis puntual de la construcción nos basamos en el trabajo ya clásico, dentro de la gramática generativa, de Rizzi (1997), quien propone descomponer el Sintagma de Complementante en tres proyecciones básicas relativas a la estructura informacional de la oración: el Sintagma de Foco, el Sintagma de Tópico y el Sintagma de Fuerza, que determina el tipo semántico de la cláusula (interrogativo, imperativo, etc.).","palabras_clave":"ESPAÑOL|GUARANÍ|HENDIDAS|FOCALIZACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18817,"idioma_id":4,"titulo":"Effects of Different PER Translational Kinetics on the Dynamics of a Core Circadian Clock Model","resumen":"Living beings display self-sustained daily rhythms in multiple biological processes, which persist in the absence of external cues since they are generated by endogenous circadian clocks. The period (per) gene is a central player within the core molecular mechanism for keeping circadian time in most animals. Recently, the modulation PER translation has been reported, both in mammals and flies, suggesting that translational regulation of clock components is important for the proper clock gene expression and molecular clock performance. Because translational regulation ultimately implies changes in the kinetics of translation and, therefore, in the circadian clock dynamics, we sought to study how and to what extent the molecular clock dynamics is affected by the kinetics of PER translation. With this objective, we used a minimal mathematical model of the molecular circadian clock to qualitatively characterize the dynamical changes derived from kinetically different PER translational mechanisms. We found that the emergence of self-sustained oscillations with characteristic period, amplitude, and phase lag (time delays) between per mRNA and protein expression depends on the kinetic parameters related to PER translation. Interestingly, under certain conditions, a PER translation mechanism with saturable kinetics introduces longer time delays than a mechanism ruled by a first-order kinetics. In addition, the kinetic laws of PER translation significantly changed the sensitivity of our model to parameters related to the synthesis and degradation of per mRNA and PER degradation. Lastly, we found a set of parameters, with realistic values, for which our model reproduces some experimental results reported recently for Drosophila melanogaster and we present some predictions derived from our analysis.","palabras_clave":"RELOJ CIRCADIANO|PERIODO|MODELADO MATEMATICO|TRADUCCION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18820,"idioma_id":4,"titulo":"Generation of large and locally aligned wormlike micelles in block copolymer\/epoxy blends","resumen":"A dispersion of wormlike micelles, empirically found in some block copolymer (BCP)\/epoxy blends, has been reported to produce a significant toughening of epoxy networks. In this study, a rationale procedure to generate and trap large and locally aligned wormlike micelles in an epoxy matrix is reported. A BCP\/epoxy\/hardener blend was selected that was homogeneous at the polymerization temperature but became nanostructured in the course of polymerization leading to hexagonally packed cylinders (HPC) domains. When a similar BCP with a molar mass about three times larger than the first one and with the same ratio between blocks was used, the nanostructuration into HPC domains was frustrated by diffusional limitations of the large cylindrical micelles generated. A morphology consisting of a dispersion of large and locally aligned wormlike micelles was trapped in the cross-linked epoxy. The selected BCP was polystyrene (PS)-b-poly(ethylene oxide) (PEO), with molar masses M = 43 kDa or 136 kDa and a mass fraction of PEO close to 25 wt%. The network precursors were based on diglycidylether of bisphenol A (DGEBA) and 4,4&#8242;-methylenebis(2,6-diethylaniline) (MDEA). Low- and high-molar-mass BCP generated, respectively, HPC domains and wormlike micelles, as supported by TEM images and SAXS spectra.","palabras_clave":"Block copolymer|Hexagonally packed cylinders|Polymerization-induced self-assembly|PS-b-PEO\/epoxy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18821,"idioma_id":4,"titulo":"Reprint of: Self-assembly of nanoparticles employing polymerization-induced phase separation","resumen":"Nanoparticles (NPs) may be homogeneously dispersed in the precursors of a polymer (reactive solvent) by an adequate selection of their stabilizing ligands. However, the dispersion can become metastable or unstable in the course of polymerization. If this happens, NP-rich domains can be segregated by a process called polymerization-induced phase separation (PIPS). This occurs mainly due to the decrease in the entropic contribution of the reactive solvent to the free energy of mixing (increase in its average size) and, for a reactive solvent generating a cross-linked polymer, the additional contribution of the elastic energy in the post-gel stage. The extent of PIPS will depend on the competition between phase separation and polymerization rates. It can be completely avoided, limited to a local scale or conveyed to generate different types of NPs? aggregates such as crystalline platelets, self-assembled structures with a hierarchical order and partitioning at the interface, and bidimensional patterns of NPs at the film surface. The use of a third component in the initial formulation such as a linear polymer or a block copolymer, provides the possibility of generating an internal template for the preferential location and self-assembly of phase-separated NPs. Some illustrative examples of morphologies generated by PIPS in solutions of NPs in reactive solvents, are analyzed in this feature article.","palabras_clave":"Block copolymers|Nanoparticle?polymer blends|Phase separation|Polymerization-induced phase separation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18822,"idioma_id":4,"titulo":"ASteCA - Automated Stellar Cluster Analysis","resumen":"We present the Automated Stellar Cluster Analysis package (\texttt{ASteCA}), a suit of tools designed to fully automate the standard tests applied on stellar clusters to determine their basic parameters. The set of functions included in the code make use of positional and photometric data to obtain precise and objective values for a given cluster´s center coordinates, radius, luminosity function and integrated color magnitude, as well as characterizing through a statistical estimator its probability of being a true physical cluster rather than a random overdensity of field stars.  \texttt{ASteCA} incorporates a Bayesian field star decontamination  algorithm capable of assigning membership probabilities using  photometric data alone. An isochrone fitting process based on the  generation of synthetic clusters from theoretical isochrones and  selection of the best fit through a genetic algorithm is also present,  which allows \texttt{ASteCA} to provide accurate estimates for a  cluster´s metallicity, age, extinction and distance values along with  its uncertainties.\\To validate the code we applied it on a large set of  over 400 synthetic \texttt{MASSCLEAN} clusters with varying degrees of  field star contamination as well as a smaller set of 20 observed Milky  Way open clusters (Berkeley 7, Bochum 11, Czernik 26, Czernik 30,  Haffner 11, Haffner 19, NGC 133, NGC 2236, NGC 2264, NGC 2324, NGC 2421,  NGC 2627, NGC 6231, NGC 6383, NGC 6705, Ruprecht 1, Tombaugh 1, Trumpler 1, Trumpler 5 and Trumpler 14) studied in the literature.  The results show that \texttt{ASteCA} is able to recover cluster parameters with an acceptable precision even for those clusters  affected by substantial field star contamination. \texttt{ASteCA} is  written in Python and is made available as an open source code which can be downloaded ready to be used from its official site.","palabras_clave":"CLUSTERS|STATISTICAL|PYTHON|AUTOMATIC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18823,"idioma_id":4,"titulo":"Identification and Control of a Cryogenic Current Comparator using Robust Control Theory","resumen":"Abstract?This paper presents the model identification of a  cryogenic current comparator (CCC). A dynamic model set is  computed and compared with experimental data in order to  provide a realistic dynamical behavior of the system. Due to the  fact that the final purpose is to improve the performance of the  CCC, an H1 optimal controller is designed, based on this model  set. In this framework, a robust stability theoretical guarantee is  provided and simulations of the closed loop system illustrate the  robustness improvement.","palabras_clave":"Control|Resistance|Metrology|Squid"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18824,"idioma_id":5,"titulo":"Debates y decisiones políticas en torno de la exhibición de restos humanos en el Museo de La Plata","resumen":"Desde  hace algunas décadas, el Museo de La Plata (Universidad Nacional de La Plata,  Argentina) ha recibido reclamos por parte de comunidades aborígenes que  solicitan la restitución de restos humanos, así como su retiro de las salas de  exhibición. Conjuntamente con la aparición de normativas que reconocen derechos  en los pueblos originarios y el debate de la propia comunidad académica, se ha  desarrollado en los últimos años una política integral en relación con el  manejo de restos humanos dentro de la institución. El objetivo de este trabajo  es presentar los acontecimientos, debates y decisiones acerca de la modalidad  de exhibición de restos humanos en el Museo de La Plata. El principal cambio se  produjo en 2006, cuando se decidió retirar de exhibición las momias y partes  esqueletarias de poblaciones aborígenes de América y, paralelamente, la  elaboración de mensajes a los visitantes según estas decisiones políticas. El  nuevo guión de la exposición gira en torno a la evolución humana, contemplando  la inclusión de un sector especialmente dedicado a la reflexión sobre el  significado de prácticas y representaciones sobre la muerte y los muertos, el  valor del estudio científico sobre este tipo de evidencias y los derechos de  las comunidades sobre sus muertos","palabras_clave":"política|comunidades aborigenes|visitantes |museos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18825,"idioma_id":4,"titulo":"Time Recovery for a Complex Process Using Accelerated Dynamics","resumen":"The hyperdynamics method (HD) developed by Voter [J. Chem. Phys. 106 (1996)11] sets the theoretical basis to construct an accelerated simulation scheme that holds the time scale information. Since HD is based on transition state theory, pseudo-equilibrium condition (PEC) must be satisfied before any system in a trapped state may be accelerated. As the system evolves, many trapped states may appear and the PEC must be assumed in each one to accelerate the escape. However, since the system evolution is a priori unknown, the PEC cannot be permanently assumed as true.Furthermore, the different parameters of the bias function used may need drastic recalibration during this evolution. To overcome this problems we present a general scheme to switch between HD and conventional molecular dynamics (MD) in an automatic fashion during the simulation. To decide when HD should start and finish, criteria based on the energetic properties of the system are introduced. On the other hand, a very simple bias function is proposed leading to a straightforward on-the-fly set up of the required parameters. A way to measure the quality of the simulation is proposed.The efficiency of the present hybrid HD-MD method is tested for a two-dimensional model potential and for the coalescence process of two nanoparticles. In spite of the important complexity of the latter system (165 degrees of freedoms), some relevant mechanistic properties were recovered within the present method.","palabras_clave":"accelerated dynamics|hyperdynamics|nanoparticle coalescence|hybrid method"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18826,"idioma_id":4,"titulo":"Synthesis and characterization of the new two-dimensional Heisenberg antiferromagnet double perovskite BaLaCuSbO6","resumen":"The BaLaCuSbO6 double perovskite has been successfully synthesized by solid state reaction under an air atmosphere. Its structure was refined using powder neutron diffraction in the monoclinic space group I2\/m with a 4% antisite disorder on the B cations. Magnetic measurements give signs of 2D-antiferro- magnetic behaviour with TN around 64 K. The Jahn?Teller distortion produced by Cu2+ ions favours a crystallographic tetragonal distortion and consequently the in-plane super?superexchange antiferro- magnetic interactions, J90°, are favoured over the in-plane J180° antiferromagnetic exchange interactions. Both, J and J? magnetic interactions have been evaluated according to a Heisenberg antiferromagnetic rectangular model using an approximation to Curie?s law in powers of J\/T, being |J| around 10 times stronger than |J?|.","palabras_clave":"Double Perovskites|Crystalline Structure|Magnetism"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18828,"idioma_id":4,"titulo":"The Parkinson-associated human P5B-ATPase ATP13A2 protects against the iron-induced cytotoxicity","resumen":"P-type ion pumps are membrane transporters that have been classified into five subfamilies termed P1-P5. The ion transported by the P5-ATPases is not known. Five genes named ATP13A1-ATP13A5 that belong to the P5-ATPase group are present in humans. Loss of function mutations in the ATP13A2 gene (PARK9, OMIM 610513) underlay a form of Parkinson?s disease (PD) known as Kufor Rakeb Syndrome (KRS), which belongs to the group of syndromes of neurodegeneration with brain iron accumulation (NBIA).   Here we report that the cytotoxicity induced by iron exposure was two-fold reduced in CHO cells stably expressing the ATP13A2 recombinant protein (ATP13A2). Moreover, the iron content in ATP13A2 cells was lower than control cells stably expressing an inactive mutant of ATP13A2. ATP13A2 expression caused an enlargement of lysosomes and late endosomes. ATP13A2 cells exhibited a reduced iron-induced lysosome membrane permeabilization (LMP). These results suggest that ATP13A2 overexpression improves the lysosome membrane integrity and protects against the iron-induced cell damage.","palabras_clave":"P-type ATPase|P5B ATP13A2|Iron|Lysosome membrane permeabilization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18829,"idioma_id":4,"titulo":"Characteristics of the extreme events observed in the Kerr-lens mode-locked Ti:sapphire laser","resumen":"Kerr-lens mode-locked Ti:sapphire lasers are known to display three coexistent modes of operation: continuous wave, transform limited pulses (P1), and positive chirped pulses (P2). Extreme events (sometimes also called optical rogue waves), in the form of pulses of high energy appearing much often than in a Gaussian distribution, are observed in the chaotic regime of the P2 mode, but not of P1. The extreme events in P2 appear unpredictably, but their separation (measured in number of round trips) is a simple combination of the numbers 11 and 12 (which were named ?magic numbers?). The existence of extreme events in P2 and not in P1, and also of the magic numbers, have been successfully reproduced by numerical simulations based on a five-variables iterative map, but the intuitive insight on the physical causes has been limited. In this paper, we present evidence that the extreme events in this laser appear if the amount of self phase modulation on the pulses is above a certain threshold, and also that the P1 mode becomes unstable before crossing that threshold. This explains why theextreme events are observed in P2, and not in P1. Remarkably, even though the values of self-phase modulation on all the pulses (in the chaotic regime) are widely spread, the values inside the set of extreme events are relatively well defined. Finally, the magic numbers are found to be the residuals of the periodical orbits of the ?cold? laser cavity when they are perturbed by the opposite effects of a dissipative term, due to the presence of transversal apertures, and an expansive term, due to the self-focusing.","palabras_clave":"DYNAMICS|NON LINEAR OPTICS|LASERS|ULTRAFAST PULSES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18830,"idioma_id":4,"titulo":"Sperm head ellipticity as a heat stress indicator in Australian Merino rams (Ovis aries) in Northern Patagonia, Argentina","resumen":"In Northern Patagonia, Argentina, the ovine mating season starts on March 15, which is the time when rams are submitted to summer temperatures. This study assessed the adaptability of 12 Australian Merino rams, six unshorn and six shorn, half of which were treated in a heat chamber for five days (09.00 hours to 17.00 hours) that gradually reached 40 C. In an attempt to quantify the effects of heat stress on sperm head morphology, ellipticity was analyzed to establish the relationship between the distributions of subpopulations, light hours, temperature and humidity. Ellipticitywasmeasured on 9224 sperm heads thatwere obtained over 12 weeks starting in the summer time. Four sperm head subpopulations (S) were identified by comparison with a sperm head population of ejaculates obtained in the late breeding season without the effect ofheat stress (S1¼heads withellipticity2.00; S2¼spermheadwithrange of ellipticity between 1.80 and 1.99; S3¼spermhead with range of ellipticity from1.60 to 1.79; and S4 ¼ sperm head with range of ellipticity from 1.30 to 1.59). The variable sperm head ellipticity for each ejaculatewas expressed as themeansandfrequencies of subpopulation. The results demonstrate changes in ram sperm head ellipticity in different conditions (control\/treated, unshorn\/shorn) throughout the experiment (P &lt; 0.05). Treated shorn rams had a highermean ellipticity and frequency of elliptical heads (mean ellipticity value ¼ 2.06 and S1 frequency ¼ 76.35%), peaking in the seventhweek posttreatment (on the basis of the action of heat stress on seminiferous tubules). According to this study, unshorn rams were better adapted to heat stress than the shorn ones.five days (09.00 hours to 17.00 hours) that gradually reached 40 C. In an attempt to quantify the effects of heat stress on sperm head morphology, ellipticity was analyzed to establish the relationship between the distributions of subpopulations, light hours, temperature and humidity. Ellipticitywasmeasured on 9224 sperm heads thatwere obtained over 12 weeks starting in the summer time. Four sperm head subpopulations (S) were identified by comparison with a sperm head population of ejaculates obtained in the late breeding season without the effect ofheat stress (S1¼heads withellipticity2.00; S2¼spermheadwithrange of ellipticity between 1.80 and 1.99; S3¼spermhead with range of ellipticity from1.60 to 1.79; and S4 ¼ sperm head with range of ellipticity from 1.30 to 1.59). The variable sperm head ellipticity for each ejaculatewas expressed as themeansandfrequencies of subpopulation. The results demonstrate changes in ram sperm head ellipticity in different conditions (control\/treated, unshorn\/shorn) throughout the experiment (P &lt; 0.05). Treated shorn rams had a highermean ellipticity and frequency of elliptical heads (mean ellipticity value ¼ 2.06 and S1 frequency ¼ 76.35%), peaking in the seventhweek posttreatment (on the basis of the action of heat stress on seminiferous tubules). According to this study, unshorn rams were better adapted to heat stress than the shorn ones.","palabras_clave":"Merino ram|Heat stress|Sperm head ellipticity|Unshorn\/shorn"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18831,"idioma_id":4,"titulo":"New method to evaluate the 7Li(p, n)7Be reaction near threshold","resumen":"In this work a complete description of the 7Li(p,n)7Be reaction near threshold is given using center-ofmass and relative coordinates. It is shown that this standard approach, not used before in this context, leads to a simple mathematical representation which gives easy access to all relevant quantities in the reaction and allows a precise numerical implementation. It also allows in a simple way to include proton beam-energy spread affects. The method, implemented as a C++ code, was validated both with numericaland experimental data finding a good agreement. This tool is also used here to analyze scattered published measurements such as (p,n) cross sections, differential and total neutron yields for thick targets. Using these data we derive a consistent set of parameters to evaluate neutron production near threshold. Sensitivity of the results to data uncertainty and the possibility of incorporating new measurements are also discussed.","palabras_clave":"7Li(p, n)7Be reaction near threshold Cross section  |Neutron yield  |Accelerator-based neutron source |Boron Neutron Capture Therapy (BNCT)"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18832,"idioma_id":4,"titulo":"A simple method for determining the lattice parameter and chemical composition in ternary bcc-Fe rich nanocrystals","resumen":"Charts containing lattice parameters of Fe1x(M,N)x ternary systems with M and N = Si, Al, Ge or Co, and 0 6 x 6 0.3,were developed by implementing a linear relationship between the respective binary alloys with the same solute content of the ternary one. Charts were validated with experimental data obtained from literature. For the Fe?Co?Si system, the linear relationship does not fit the experimental data. For the other systems (except the Fe?Co?Ge one where no experimental data was found), the lineal relationship constitute a very good approximation. Using these charts and the lattice parameter data obtained from X-ray diffraction technique combining with the solute content data obtained from Mössbauer spectroscopy technique it is possible to determine the chemical composition of nanograins in soft magnetic nanocomposite materials and some examples are provided.","palabras_clave":"Nanostructured materials|Metals and alloys|Crystal structure|Phase diagrams|X-ray diffraction|Mössbauer spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18833,"idioma_id":4,"titulo":"TOXIC TRACE ELEMENT CONTENTS IN GLUTEN-FREE CEREAL BARS MARKETED IN ARGENTINA","resumen":"Celiac disease is a food intolerance triggered by the ingestion of gluten-containing cereals; the only therapy is a strict gluten-free diet for life. In recent years, gluten-free cereal bars has achieved considerable attention as an interesting alternative food considering its several advantages, such as functional properties, nutritional contents, variety of presentations and flavors. The aim of this study was to determine the contents of three toxic trace elements (arsenic, cadmium and lead) in commercial gluten-free cereal bars marketed in Argentina by ICP-MS and assess the dietary intake of the three toxic elements compared with reference values. The results obtained indicated that the highest total concentration of arsenic is provided by the gluten-free cereal bars with green apple pomace (28.2 µg\/kg) and the levels of cadmium were lower than 10 µg\/kg or even below MDL in all samples. The lead contents in all bars with honey samples were exceptionally higher than in the other samples (levels greater than 130 µg\/kg). The intake of available gluten-free cereal bars are generally safe for consumers, but particular attention should be paid to monitor the content of arsenic and lead gluten-free cereal bars to ensure the quality of the product. Further studies are necessary to achieve an exact risk evaluation, concerning the bioavailability of trace elements in gluten-free food sources.","palabras_clave":"MINERAL|ICP-MS|LEAD|ARSENIC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18835,"idioma_id":4,"titulo":"Low X-ray luminosity galaxy clusters - III. Weak lensing mass determination at 0.18 < z < 0.70","resumen":"This is the third of a series of papers of low X-ray luminosity galaxy clusters. In this work we present the weak lensing analysis of eight clusters, based on observations obtained with the Gemini Multi-Object Spectrograph in the g', r' and i' passbands. For this purpose, we have developed a pipeline for the lensing analysis of ground-based images and we have performed tests applied to simulated data. We have determined the masses of seven galaxy clusters, five of them measured for the first time. For the four clusters with availably spectroscopic data, we find a general agreement between the velocity dispersions obtained via weak lensing assuming a singular isothermal sphere profile, and those obtained from the redshift distribution of member galaxies. The correlation between our weak lensing mass determinations and the X-ray luminosities is suitably fitted by other observations of the M-LX relation and models.","palabras_clave":"GRAVITATIONAL LENSING|DARK MATTER|X-RAY GALAXY CLUSTERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18836,"idioma_id":4,"titulo":"Disrupting Buchnera aphidicola, the endosymbiotic bacteria of Myzus persicae, delays host plant acceptance","resumen":"Myzus persicae Sulzer, like almost all aphids,associates with the endosymbiotic bacterium, Buchnera aphidicola. Although the accepted function of B. aphidicola is to complete the aphid diet with nutrients such as essential amino acids and vitamins, there is evidence that the bacteria may participate in the plant-insect interaction. Moreover, bacterial proteins with potential effector action on the metabolism of the host plant have been identified in the saliva of M. persicae. However, the possible involvement of B. aphidicola in relation to host plant acceptance by aphids needs further investigation. The aim of this study was to evaluate the effect that the disruption of the B. aphidicola-M. persicae symbiosis has on aphid feeding behaviour and on the expression of aphid salivary genes. The antibiotic rifampicin was administrated to adult aphids through artificial diets to disrupt the bacterial primary endosymbionts. Comparisons were made with control aphids, feeding from diet without rifampicin, as well as normal aphids fed on radish plants. Differences were found in the feeding behaviour of aposymbiotic aphids, which had delayed host acceptance and problems during stylet penetration into host plants. It was also found that B. aphidicola disruption down-regulated the expression of the Mp63 salivary protein gene. Together, these results indicate that B. aphidicola plays a role in plant-aphid interactions. The validity of the use of artificial diets in plant aphid studies is also discussed.","palabras_clave":"EPG TECHNIQUE|APHID PRIMARY ENDOSYMBIONT|GREEN PEACH APHID|ARTIFICIAL DIETS|APHID SALIVARY GENES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18837,"idioma_id":4,"titulo":"The influence of topography on vertical velocity of air in relation to severe storms near the Southern Andes Mountains","resumen":"On the basis of 180 storms which took place between 2004 and 2011 over   the province of Mendoza (Argentina) near to the Andes Range at southern   mid-latitudes, we consider those registered in the northern and central   crop areas (oases). The regions affected by these storms are currently   protected by an operational hail mitigation project. Differences with   previously reported storms detected in the southern oasis are   highlighted. Mendoza is a semiarid region situated roughly between 32S   and 37S at the east of the highest Andes top. It forms a natural   laboratory where different sources of gravity waves, mainly mountain   waves, occur. In this work, we analyze the effects of flow over   topography generating mountain waves and favoring deep convection. The   joint occurrence of storms with hail production and mountain waves is   determined from mesoscale numerical simulations, radar and radiosounding   data. In particular, two case studies that properly represent diverse   structures observed in the region are considered in detail. A continuous   wavelet transform is applied to each variable and profile to detect the   main oscillation modes present. Simulated temperature profiles are   validated and compared with radiosounding data. Each first radar echo,   time and location are determined. The necessary energy to lift a parcel   to its level of free convection is tested from the Convective Available   Potential Energy and Convection Inhibition. This last parameter is   compared against the mountain waves´ vertical kinetic energy. The time   evolution and vertical structure of vertical velocity and equivalent   potential temperature suggest in both cases that the detected mountain   wave amplitudes are able to provide the necessary energy to lift the air   parcel and trigger convection. A simple conceptual scheme linking the   dynamical factors taking place before and during storm development is   proposed.","palabras_clave":"Mountain waves|Storms|Andes    |Mendoza"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18838,"idioma_id":5,"titulo":"Impacto del cambio climático en Mendoza. Variación climática en los últimos 50 años. Mirada desde la fisiología de la vid","resumen":"El IPCC (Panel Intergubernamental sobre Cambio Climático) ha pronosticadocambios principalmente en las temperaturas, precipitaciones y eventos extremos. Ya se han detectado durante el siglo XX aumentos en la temperatura de la superficie del globo terrestre de 0,6°C±0,2°C. La fisiología, productividad y ciclo fenológico de las plantas depende de las condiciones climáticas. En este trabajo, se analizaron series meteorológicas de 50 años, en tres oasis productivos de Mendoza, Argentina, a través de índices climáticos y ecológicos. Se compararon estadísticamente estos índices, en dos décadas de la serie (una inicial y otra final) y se evaluó su variación en el tiempo mediante regresión lineal. El análisis comparativo de las dos décadas mostró diferentes cambios según la zona en estudio. En la zona Este mayor número de índices que podríanafectar la viticultura sufrieron variación. En la zona Norte y Sur, el número de índices climáticos y ecológicos que presentaron cambios fueron menores que en la zona Este. Conocer los cambios climáticos ocurridos a nivel local, su magnitud en los últimos 50 años y su tendencia permitirá evaluar sus posibles impactos en la fisiología vitícola, modificación de la fenología, acumulación de azúcares y compuestos fenólicos como también elaborar nuevos estudios y estrategias para mitigar los efectos negativos.","palabras_clave":"Cambio Climático|Temperatura, precipitaciones|Vid, Fisiología|Mendoza, Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18839,"idioma_id":4,"titulo":"Extemporaneous benznidazole oral suspension prepared from commercially available tablets for treatment of Chagas disease in paediatric patients.","resumen":"Purpose: The aim of this work was to develop an extemporaneous 1% BNZ suspension, with masked taste and adequate stability starting from available commercial tablets. The quality of compounding was evaluated though content uniformity measurement and physical and microbiological stability evaluation, under different storage conditions during 90 days.   Methods: Six batches of 1 % BNZ suspension were prepared using safe excipients currently available in a galenic area of Hospital Pharmacy, and then stored at 5 and 25 °C for 90 days. The BNZ content was determined by UV-spectrophotometry. Physical stability was defined as the absence of color, odor and\/or flavor changes and the re-suspension of solid phase by a reasonable amount of simple 15-second shaking. The compliance with microbiological attributes of non-sterile pharmaceutical products was also evaluated.   Results: An oral liquid suspension, containing 1 % of BNZ, was developed from commercially available BNZ tablets. The formulations stored during 90 days were easily re-dispersed after a simple 15-second shaking, ensuring the pouring of a liquid volume containing the desired dose of BNZ. All samples were within the acceptable range of BNZ concentration with minimal standard deviations. There were no detectable changes in color, odor, viscosity, pH and microbial growth, complying with official quality requirements. The quality attributes were not affected by storage, room or refrigeration conditions or by the frequent opening or closing of the multi-dose containers.   Conclusion: Pediatric oral liquid suspension containing 1.0 % of BNZ was easily prepared starting from commercial tablets, being an interesting alternative for optimizing the pediatric treatment of Chagas disease.","palabras_clave":"BENZNIDAZOLE|CHAGAS DISEASE|COMPOUNDING|ORAL PEDIATRIC SUSPENSION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18840,"idioma_id":4,"titulo":"Earthworm assemblages in different intensity of agricultural uses and their relation to edaphic variables","resumen":"  The   objective of this study was to relate earthworm assemblage structure   with three different soil use intensities, and to indentify the   physical, chemical, and microbiological soil variables that are   associated to the observed differences. Three soil uses were evaluated:   1-Fifty year old naturalized grasslands, low use intensity; 2-Recent   agricultural fields, intermediate use intensity, and 3-Fifty year old   intensive agricultural fields, high use intensity. Three different sites   for each soil use were evaluated from winter 2008 through summer 2011.   Nine earthworm species were identified across all sampling sites. The   sites shared five species: the native Microscolex dubius, and the introduced Aporrectodea caliginosa, A. rosea, Octalasion cyaneum, and O. lacteum,   but they differed in relative abundance by soil use. The results show   that the earthworm community structure is linked to and modulated by   soil properties. Both species abundance and diversity showed significant   differences depending on soil use intensity. A principal component   analysis showed that species composition is closely related to the   environmental variability. The ratio of native to exotic species was   significantly lower in the intensive agricultural system when compared   to the other two, lower disturbance systems. Microscolex dubius abundance was related to naturalized grasslands along with soil Ca, pH, mechanical resistance, and microbial respiration. Aporrectodea caliginosa   abundance was related to high K levels, low enzymatic activity,   slightly low pH, low Ca, and appeared related to the highly disturbed   environment. Eukerria stagnalis and Aporrectodea rosea,   commonly found in the recent agricultural system, were related to high   soil moisture condition, low pH, low Ca and low enzymatic activity.   These results show that earthworm assemblages can be good indicators of   soil use intensities. In particular, Microscolex dubius, Aporrectodea caliginosa, and Aporrectodea rosea,   showed different temporal patterns and species associations, due to the   changes in soil properties attributable to soil use intensity, defined   as the amount and type of agricultural operations.","palabras_clave":"Soil ecology|Earthworms"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18841,"idioma_id":4,"titulo":"Search for a CP-odd Higgs boson decaying to Zh in pp collisions at s&#8730;=8 TeV with the ATLAS detector","resumen":"A search for a heavy, CP-odd Higgs boson, A , decaying into a Z boson and a 125 GeV Higgs boson, h , with the ATLAS detector at the LHC is presented. The search uses proton?proton collision data at a centre-of-mass energy of 8 TeV corresponding to an integrated luminosity of 20.3 fb &#8722;1 . Decays of CP-even h bosons to &#964;&#964; or bb pairs with the Z boson decaying to electron or muon pairs are considered, as well as h&#8594;bb decays with the Z boson decaying to neutrinos. No evidence for the production of an A boson in these channels is found and the 95% confidence level upper limits derived for &#963;(gg&#8594;A)×BR(A&#8594;Zh)×BR(h&#8594;ff¯) are 0.098?0.013 pb for f=&#964; and 0.57?0.014 pb for f=b in a range of mA=220?1000&nbsp;GeV . The results are combined and interpreted in the context of two-Higgs-doublet models.","palabras_clave":"ATLAS|LHC|CERN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18842,"idioma_id":4,"titulo":"Search for charged Higgs bosons decaying via H±&#8594;&#964;±&#957; in fully hadronic final states using pp collision data at s&#8730; = 8 TeV with the ATLAS detector","resumen":"The results of a search for charged Higgs bosons decaying to a &#964; lepton and a neutrino, H±&#8594;&#964;±&#957;, are presented. The analysis is based on 19.5 \/fb  of proton--proton collision data at 8 TeV collected by the ATLAS experiment at the Large Hadron Collider. Charged Higgs bosons are searched for in events consistent with top-quark pair production or in associated production with a top quark. The final state is characterised by the presence of a hadronic &#964; decay, missing transverse momentum, b-tagged jets, a hadronically decaying W boson, and the absence of any isolated electrons or muons with high transverse momenta. The data are consistent with the expected background from Standard Model processes. A statistical analysis leads to 95% confidence-level upper limits on the product of branching ratios &#57902;(t&#8594;bH±)×&#57902;(H±&#8594;&#964;±&#957;), between 0.23% and 1.3% for charged Higgs boson masses in the range 80--160 GeV. It also leads to 95% confidence-level upper limits on the production cross section times branching ratio, &#963;(pp&#8594;tH±+X)×&#57902;(H±&#8594;&#964;±&#957;), between 0.76 pb and 4.5 fb, for charged Higgs boson masses ranging from 180 GeV to 1000 GeV. In the context of different scenarios of the Minimal Supersymmetric Standard Model, these results exclude nearly all values of tan&#946; above one for charged Higgs boson masses between 80 GeV and 160 GeV, and exclude a region of parameter space with high tan&#946; for H± masses between 200 GeV and 250 GeV.","palabras_clave":"ALTAS ENERGIAS|ATLAS|HIGGS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18843,"idioma_id":4,"titulo":"Search for the bb¯ decay of the Standard Model Higgs boson in associated (W\/Z)H production with the ATLAS detector","resumen":"search for the bb¯ decay of the Standard Model Higgs boson is performed with the ATLAS experiment using the full dataset recorded at the LHC in Run 1. The integrated luminosities used from pp collisions at s&#8730;=7 and 8 TeV are 4.7 and 20.3 fb&#8722;1, respectively. The processes considered are associated (W\/Z)H production, where W&#8594;e&#957;\/&#956;&#957;, Z&#8594;ee\/&#956;&#956; and Z&#8594;&#957;&#957;. The observed (expected) deviation from the background-only hypothesis corresponds to a significance of 1.4 (2.6) standard deviations and the ratio of the measured signal yield to the Standard Model expectation is found to be &#956;=0.52±0.32(stat.)±0.24(syst.) for a Higgs boson mass of 125.36 GeV. The analysis procedure is validated by a measurement of the yield of (W\/Z)Z production with Z&#8594;bb¯ in the same final states as for the Higgs boson search, from which the ratio of the observed signal yield to the Standard Model expectation is found to be 0.74±0.09(stat.)±0.14(syst.).","palabras_clave":"ATLAS|ALTAS ENERGIAS|HIGGS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18844,"idioma_id":4,"titulo":"Measurement of Spin Correlation in Top-Antitop Quark Events and Search for Top Squark Pair Production in pp Collisions at s&#8730;=8 TeV Using the ATLAS Detector","resumen":"A measurement of spin correlation in tt¯ production is presented using data collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 20.3 fb&#8722;1. The correlation between the top and antitop quark spins is extracted from dilepton tt¯ events by using the difference in azimuthal angle between the two charged leptons in the laboratory frame. In the helicity basis the measured degree of correlation corresponds to Ahelicity=0.38±0.04, in agreement with the Standard Model prediction. A search is performed for pair production of top squarks with masses close to the top quark mass decaying to predominantly right-handed top quarks and a light neutralino, the lightest supersymmetric particle. Top squarks with masses between the top quark mass and 191 GeV are excluded at the 95% confidence level.","palabras_clave":"HIGH ENERGY|ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18845,"idioma_id":4,"titulo":"Measurement of the WW+WZ cross section and limits on anomalous triple gauge couplings using final states with one lepton, missing transverse momentum, and two jets with the ATLAS detector at s&#8730;=7 TeV","resumen":"The production of a W boson decaying to e&#957; or &#956;&#957; in association with a W or Z boson decaying to two jets is studied using 4.6 fb&#8722;1 of proton--proton collision data at s&#8730;=7 TeV recorded with the ATLAS detector at the LHC. The combined WW+WZ cross section is measured with a significance of 3.4&#963; and is found to be 68±7 (stat.)±19 (syst.) pb, in agreement with the Standard Model expectation of 61.1±2.2 pb. The distribution of the transverse momentum of the dijet system is used to set limits on anomalous contributions to the triple gauge coupling vertices and on parameters of an effective-field-theory model.","palabras_clave":"HIGH ENERGY|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18846,"idioma_id":4,"titulo":"Search for invisible particles produced in association with single-top-quarks in proton-proton collisions at s&#8730; = 8 TeV with the ATLAS detector","resumen":"search for the production of single-top-quarks in association with missing energy is performed in proton--proton collisions at a centre-of-mass energy of s&#8730; = 8 TeV with the ATLAS experiment at the Large Hadron Collider using data collected in 2012, corresponding to an integrated luminosity of 20.3 fb&#8722;1. In this search, the W boson from the top quark is required to decay into an electron or a muon and a neutrino. No deviation from the Standard Model prediction is observed, and upper limits are set on the production cross-section for resonant and non-resonant production of an invisible exotic state in association with a right-handed top quark. In the case of resonant production, for a spin-0 resonance with a mass of 500 GeV, an effective coupling strength above 0.15 is excluded at 95% confidence level for the top quark and an invisible spin-1\/2 state with mass between 0 GeV and 100 GeV. In the case of non-resonant production, an effective coupling strength above 0.2 is excluded at 95% confidence level for the top quark and an invisible spin-1 state with mass between 0 GeV and 657 GeV.","palabras_clave":"ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18847,"idioma_id":4,"titulo":"Search for dark matter in events with heavy quarks and missing transverse momentum in pp collisions with the ATLAS detector","resumen":"This article reports on a search for dark matter pair production in association with bottom or top quarks in 20.3fb&#8722;1 of pp collisions collected at s&#8730;=8 TeV by the ATLAS detector at the LHC. Events with large missing transverse momentum are selected when produced in association with high-momentum jets of which one or more are identified as jets containing b-quarks. Final states with top quarks are selected by requiring a high jet multiplicity and in some cases a single lepton. The data are found to be consistent with the Standard Model expectations and limits are set on the mass scale of effective field theories that describe scalar and tensor interactions between dark matter and Standard Model particles. Limits on the dark-matter--nucleon cross-section for spin-independent and spin-dependent interactions are also provided. These limits are particularly strong for low-mass dark matter. Using a simplified model, constraints are set on the mass of dark matter and of a coloured mediator suitable to explain a possible signal of annihilating dark matter.","palabras_clave":"ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18848,"idioma_id":4,"titulo":"Mechanical stability of Zinc Oxide nanowires under tensile loading: Is Wurtzite stable at the nanoscale?","resumen":"The mechanical response of zinc oxide nanowires under uniaxial tensile loading is investigated by molecular dynamics and supported by density functional calculations. Previous theoretical works predict a stress- induced phase transition which has not been observed experimentally in zinc oxide nanowires up to date. Here, we report an explanation for such a discrepancy. Our simulations reveal brittle failure atroom temperature without phase transformation, in agreement with experiments. Interestingly, we also find that if the temperature is raised to 600 K, the phase transition occurs. A detailed reaction mechanism is proposed. For the first time, the associated rate constant has been calculated. Based on these results we propose an experimental procedure to finally observe the predicted phase transformation.","palabras_clave":"wurtzite|nanoscale|nanowires|nanochains"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18849,"idioma_id":4,"titulo":"Measurements of the W production cross sections in association with jets with the ATLAS detector","resumen":"This paper presents cross sections for the production of a W boson in association with jets, measured in proton--proton collisions at s&#8730;=7 TeV with the ATLAS experiment at the Large Hadron Collider. With an integrated luminosity of 4.6fb&#8722;1, this data set allows for an exploration of a large kinematic range, including jet production up to a transverse momentum of 1 TeV and multiplicities up to seven associated jets. The production cross sections for W bosons are measured in both the electron and muon decay channels. Differential cross sections for many observables are also presented including measurements of the jet observables such as the rapidities and the transverse momenta as well as measurements of event observables such as the scalar sums of the transverse momenta of the jets. The measurements are compared to numerous QCD predictions including next-to-leading-order perturbative calculations, resummation calculations and Monte Carlo generators.","palabras_clave":"ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18850,"idioma_id":4,"titulo":"Charge coupled devices for detection of coherent neutrino-nucleus scattering","resumen":"In this article the feasibility of using charge coupled devices (CCD) to detect low-energy neutrinos through their coherent scattering with nuclei is analyzed. The detection of neutrinos through this standard model process has been elusive because of the small energy deposited in such interaction. Typical particle detectors have thresholds of a few keV, and most of the energy deposition expected from coherent scattering is well below this level. The CCD detectors discussed in this paper can operate at a threshold of approximately 30 eV, making them ideal for observing this signal. On a CCD array of 500 g located next to a power nuclear reactor the number of coherent scattering events expected is about 3000 events\/year. Our results shows that a detection with a confidence level of 99% can be reached within 16 days of continuous operation; with the current 52 g detector prototype this time lapse extends to five months.","palabras_clave":"CCD|Neutrino|coherent enhancement"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18851,"idioma_id":4,"titulo":"Visual Analysis of Spatio-Temporal Data: Applications in Weather Forecasting","resumen":"Weather conditions affect multiple aspects of human life such as   economy, safety, security, and social activities. For this reason,   weather forecast plays a major role in society. Currently weather   forecasts are based on Numerical Weather Prediction (NWP) models that   generate a representation of the atmospheric flow. Interactive   visualization of geo-spatial data has been widely used in order to   facilitate the analysis of NWP models. This paper presents a   visualization system for the analysis of spatio-temporal patterns in   short-term weather forecasts. For this purpose, we provide an   interactive visualization interface that guides users from simple visual   overviews to more advanced visualization techniques. Our solution   presents multiple views that include a timeline with geo-referenced   maps, an integrated webmap view, a forecast operation tool, a   curve-pattern selector, spatial filters, and a linked meteogram. Two key   contributions of this work are the timeline with geo-referenced maps   and the curve-pattern selector. The latter provides novel functionality   that allows users to specify and search for meaningful patterns in the   data. The visual interface of our solution allows users to detect both   possible weather trends and errors in the weather forecast model.We   illustrate the usage of our solution with a series of case studies that   were designed and validated in collaboration with domain experts.","palabras_clave":"Picture\/Image GenerationViewing algorithms |Methodology and Techniques Interaction techniques|ApplicationsWeather Forecast Analysis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18852,"idioma_id":5,"titulo":"Lo que mueve la danza: representaciones y prácticas sociales de intervención en el espacio público para el cambio social","resumen":"Este artículo focaliza en las prácticas sociales de intervención en el espacio público promovidas en la capital bonaerense por la Asociación de Coreógrafos, Intérpretes y Afines de Danza Independiente Platense (ACIADIP) para dar a conocer e impulsar el proyecto por la Ley Nacional de Danzas.Se analizaron las representaciones sociales sobre las prácticas y los sentidos de cambio social construidos por los protagonistas en relación con su intervención.Para abordar este estudio se realizaron entrevistas, observaciones participantes y relevamiento de materiales en redes sociales.","palabras_clave":"INTERVENCIÓN|ESPACIO PÚBLICO|REPRESENTACIONES SOCIALES|CAMBIO SOCIAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18853,"idioma_id":4,"titulo":"Does edge effect and patch size affect the interaction between ants  and Croton lachnostachyus in fragmented landscapes of Chaco forest?","resumen":"Little is known about the role of ants visiting  extrafloral nectaries (EFNs) of plants in fragmented forests  of South America. The aim of this work was to determine  whether patch size and edge effect affect the composition  and frequency of ants that visit the EFNs of Croton lachnostachyus,  and how these changes may alter the reproductive  success of plants in a fragmented landscape of the  Chaco forest, Argentina. Data were analyzed considering  patch size and edge effects?as indicators of fragmentation?  on ant assemblages visiting plants and on plant reproductive  success through a field experiment. Ant species  composition differed between the edge and interior of  fragments, but not among fragments of different sizes.  Dolichoderinae species and some bigger ants as Camponotus  mus (Formicinae) were more abundant at the  edges, whereas Myrmicinae ants dominated the interior of  fragments. Foliar damage was higher in plants located at  interior than at edges of fragments. The ant-exclusion experiment  showed that seed mass, germinability, and foliar  damage did not differ between control and ant-excluded  plants. In contrast, fruit (year 2011) and seed production  (years 2010 and 2011) was higher in control plants. We  highlight the importance of studying ant?plant interactions  combining different attributes of biodiversity (composition,  structure, and function) to better understand ecological  processes in fragmented landscapes.","palabras_clave":"Extrafloral nectaries|Antplant interactions|Forest fragmentation|Foliar damage"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18854,"idioma_id":5,"titulo":"La noción de relaciones entre cálculos y la producción de explicaciones en la clase de matemática como nuevos objetos de enseñanza. Su configuración en el marco de un trabajo colaborativo entre investigadores y docentes","resumen":"Este estudio da cuenta del proceso a través del cual, en el marco de un trabajo colaborativo entre investigadores y docentes, se configuran dos objetos de enseñanza de la escuela primaria: la práctica de apelar a relaciones entre cálculos para obtener resultados y la de elaborar explicaciones en la clase de matemática. Intentamos mostrar vínculos entre la configuración de estos objetos -el análisis de su sentido y de condiciones favorables para su funcionamiento en el aula- y la construcción colectiva de una intencionalidad didáctica. Esta investigación se inscribe en un proyecto más amplio orientado a conocer el tipo de producción matemático-didáctica que puede tener lugar cuando un grupo de investigadores concurre periódicamente a una escuela para trabajar con sus maestros y directivos con el objetivo de pensar colaborativamente cuestiones de enseñanza de la matemática.","palabras_clave":"TRABAJO|COLABORATIVO|PRACTICAS|DOCENTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18855,"idioma_id":5,"titulo":"'Estudios sobre construcción de ciudadanía en la escuela secundaria argentina: tendencias y categorías en las investigaciones en la última década (2002-2012)'","resumen":"En este trabajo presentamos un estudio sobre las tendencias de la investigación social en Argentina en la temática de la construcción de la ciudadanía de los jóvenes en el nivel medio de educación. En la ponencia se analizan específicamente dos áreas de estudios: las investigaciones sobre cuerpo, género y sexualidades en la escuela, y las prácticas políticas y sus significados para los jóvenes. Nos interesa, no sólo dar cuenta de las principales investigaciones, sino fundamentalmente presentar las claves de análisis predominantes, las temáticas más abordadas así como las perspectivas desde las cuales los trabajos abordan las diversas cuestiones. El recorrido permite observar que la producción científica se concentra en la búsqueda de los sentidos que la política tiene para los sujetos, redefiniéndose en función de la perspectiva de los actores, las tendencias de las políticas educativas y las transformaciones sociales. Consideramos que este estudio puede contribuir a problematizar diferencias y similitudes entre países y la posible influencia de las problemáticas nacionales y regionales  en los estudios sobre juventud y educación.","palabras_clave":"CIUDADANÍA |JÓVENES|ESCUELA SECUNDARIA|ESTADO DEL ARTE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18856,"idioma_id":5,"titulo":"Descentrar la mirada Prácticas estatales y sistema médico en la Provincia de Río Negro, Argentina. Un aporte etnográfico para los equipos de salud.","resumen":"Los procesos y prácticas estatales producen efectos sociales, a saber: efecto de aislamiento (sujetos atomizados), efecto de identificación (subjetividades atomizadas en líneas colectivas, de pertenencia\/diferenciación), efecto de legilibilidad (producción de un saber, un lenguaje y herramientas empíricas que regulen relaciones entre colectividades) y efecto de espacialización (producción de límites y jurisdicciones) (Trouillot 2001:2).  Dentro del ámbito de la salud, estos efectos se logran, entre otras cosas, a partir de la supuesta neutralidad moral de la medicina, presumiendo que términos médicos como enfermedad y tratamiento son moralmente neutrales. Asimismo, se individualizan las dificultades humanas, ignorando o minimizando la dimensión sociocultural del comportamiento humano (Conrad 1982).   En este trabajo, nos proponemos describir y analizar desde un abordaje cualitativo -con énfasis en la perspectiva etnográfica- un reciente decreto de la Provincia de Río Negro referente a facultades de las Juntas Médicas y al ámbito de la medicina laboral. En dicho decreto se establece que si la indicación del médico tratante supera las 72 horas de licencia para un\/a empleado\/a público\/a, el 'certificado único de salud' provisto por el médico debe ser acompañado por el 'resumen de la historia clínica'.   Nuestro objetivo es analizar de qué manera la investigación cualitativa resulta una herramienta útil a la hora de develar tanto ciertas tensiones entre las normas establecidas por el mencionado decreto y las leyes de confidencialidad y de los derechos del paciente; como así también la redefinición en la relación médico - paciente al superponer a la del médico, la figura del 'contralor'.En definitiva analizaremos los aportes que la mirada etnográfica puede aportar a los equipos de salud a la hora de examinar determinados efectos de las prácticas estatales -como la creación de archivos que portan 'la fuerza de lo estatal' (Bourdieu 1996) o de novedosos vínculos entre las personas- vehiculizadas a través del sistema médico.","palabras_clave":"SISTEMA MÉDICO|APORTE ETNOGRÁFICO|PRÁCTICAS ESTATALES|PROVINCIA DE RIO NEGRO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18857,"idioma_id":4,"titulo":"On Fundamental Trade-offs of Device-to-Device Communications in Large Wireless Networks","resumen":"This paper studies the gains, in terms of served requests, attainable through out-of-band device to-device (D2D) video exchanges in large cellular networks. A stochastic framework, in which users are clustered to exchange files, is introduced, considering several aspects of this problem: the file-caching policy, user matching for exchanges, aspects regarding scheduling and transmissions. A family of admissible protocols is introduced: each protocol is composed of a clustering strategy induced by any hard-core point process, and any suitable in-cluster coordination strategy, which dictates the dynamics inside the clusters. Two metrics, quantifying the local and global fraction of video requests served  through D2D are defined, and relevant trade-off regions involving these metrics, as well as quality-of service constraints are identified. A simple coordination strategy is proposed and analyzed, to obtain  inner bounds to the trade-off regions, and draw conclusions on the performance attainable through D2D. To this end, an analysis of the time-varying interference that the nodes experience, and tight approximations of its Laplace transform are derived.","palabras_clave":"WIRELESS NETWORKS|COOPERATION|DEVICE-TO-DEVICE|STOCHASTIC GEOMETRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18859,"idioma_id":4,"titulo":". U?Pb zircon ages from the northern Austral basin and their correlation with the Early Cretaceous exhumation and volcanism of Patagonia.","resumen":"The end of the Early Cretaceous sag stage along the Southern Patagonian Andes is indicated by the sudden appearance of shallow marine to deltaic sandstones on top of deep marine facies. We studied the detrital and volcanic zircon U-Pb geochronology from the coarse-grained deposits represented by the Río Belgrano and Río Tarde formations at the northern end of the Austral or Magallanes basin. The maximum depositional age of the basal green sandstones of Río Belgrano Formation is marked by a ~122 Ma age peak. The youngest single zircon of the overlaying lower Río Tarde Formation yields an age of 118 ± 2 Ma, however the ~122 Ma age peak is equally present. The upper Río Tarde Formation yielded a 112 ± 2Ma U-Pb zircon age for a volcanic tuff. The ~122 Ma significant peak and 112 ± 2 Ma tuff represent volcanic ash fall coeval with plutonic activity dated between 125 and 110 Ma in the North Patagonian Batholith. An abundant detrital Mesozoic population is present in both units, including a 189-170Ma peak corresponding to the V1 Jurassic volcanic stage cropping out in the North Patagonian Massif. However, zircons of 153-157 Ma representing the age of Jurassic volcanism along the Patagonian basement domain to the west are scarce. Our data indicate a ~122 Ma age for the studied samples, during which the Southern Patagonian Andes received mixed basement and V1 Jurassic volcanic stage detritus. These combined sources are an outstanding characteristic of the North Patagonian and Deseado massifs, in agreement with the previously proposed Aptian uplift and exhumation of Patagonia.","palabras_clave":"PATAGONIA|EARLY CRETACEOUS|PATAGONIA ANDES|AUSTRAL BASIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18860,"idioma_id":5,"titulo":"LA INTERNACIONALIZACION Y EL MERCADO UNIVERSITARIO","resumen":"      En el contexto  Latinoamericano existen diversas investigaciones y estudios que ponen de  manifiesto que las políticas del sector universitario han variado su  conformación identitaria desde una concepción político social hacia una  concepción político mercantil. El concepto de internacionalización de la  educación superior suele abarcar una multitud de estrategias, entre ellas la  movilidad académica para estudiantes y profesores; la creación de redes  internacionales, asociaciones y proyectos; nuevos programas académicos e  iniciativas de investigación, &nbsp;la  transmisión de educación a otros países mediante universidades filiales o  franquicias, tanto presenciales o a distancia. En este sentido la  internacionalización universitaria va unida al concepto de mercantilización y  conjuntamente con ello a las necesidades de pensar las funciones de docencia,  investigación y extensión en forma global generando reformas curriculares  basadas en competencias y redefiniendo los campos según los requerimientos de  acreditación para un mercado global. En este sentido, diversos trabajos  describen cómo los diferentes campos disciplinares han sufrido fuertes  reinstitucionalizaciones de la mano de procesos de acreditación, certificación  y articulación que determinaron la fijación de estándares, así como de  criterios comunes para la formación y la habilitación profesional.      Estos procesos  actuales ponen en evidencia que los cambios ocurridos en las universidades  públicas, y por cierto de Argentina se vinculan con ese modelo imperante,  adecuando la calidad de sus acciones a una nueva cultura de interacción con el  sector productivo en busca de competitividad y excelencia.  A partir de ello, en nuestra investigación indagamos las formas en que  las culturas académicas se han ido acomodando a los cambios producidos por el  sistema de acreditación y evaluación externa, fundamentalmente en relación al  concepto de autonomía académica, elemento fuertemente incorporado a los  aspectos identitarios de la cultura universitaria argentina.","palabras_clave":"educación superior|mercantilización|reforma |internacionalización"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18861,"idioma_id":4,"titulo":"Description of safflower (Carthamus tinctorius) phenological growth stages according to the extended BBCH scale","resumen":"Safflower (Carthamus tinctorius) is an annual oilseed crop belonging to theAsteraceae family. It is adapted to semiarid growing conditions and could haveexpanded potential as an alternative, multipurpose crop in central Argentinaand other semiarid regions. Agronomic and ecophysiology research of saffloweris needed to promote its cultivation and economic potential. An accurate,standard scale describing phenological growth stages is needed to facilitate thecrop management and research. We describe phenological growth stages ofsafflower plants from seed germination to harvest maturity according to thecodes of the extended BBCH scale, a scale widely adopted throughout theworld for the description of growth developmental stages of weeds and crops.This scale uses a two-digit code, where the same code is applied to the samegrowth stages of different plant species. For each code, a description based oneasily observable external morphological characteristics is given. This work isthe first description of safflower growth stages according to the codes of theextended BBCH scale. The codification proposed here provides an accurate andsimplified approach to identify the safflower growth stages. This will provide auseful tool for farmers and researchers facilitating scientific communications atan international level.","palabras_clave":"BBCH SCALE|CARTHAMUS TINCTORIUS L.|OILSEED|PHENOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18862,"idioma_id":5,"titulo":"Los jóvenes argentinos y sus trayectorias laborales inestables: Mitos y realidades","resumen":"En el presente artículo ponemos en cuestión afirmaciones que, por su recurrencia, pasaron a conformar parte del sentido común de los estudios sobre jóvenes. La idea de mito como institución social nos aproxima a las afirmaciones que nos abocaremos a analizar, por tratarse de convenciones compartidas. En ese sentido, presentamos en estas páginas un ejercicio de contraposición de lo que denominamos mitos y realidades en torno a tres problemáticas centrales de los estudios laborales sobre jóvenes: los empleos a los que acceden, los recurrentes períodos de desocupación que atraviesan, y la configuración de sus trayectorias laborales. La amplia bibliografía sobre el tema nos ofrecerá la materia prima de lo que denominamos mitos, mientras que daremos cuenta de lo que expresamos como realidades a partir de resultados de nuestras investigaciones en curso, producto del procesamiento de datos primarios y secundarios. A tal fin, adoptamos una mirada que articula y complementa datos cuantitativos y cualitativos. Por un lado analizamos datos estadísticos de la Encuesta Permanente de Hogares del INDEC sobre el empleo de jóvenes de entre 15 y 24 años en el Gran Buenos Aires correspondientes al período 2006- 2010. Por otro lado procesamos información proveniente de un panel cualitativo longitudinal de seguimiento de trayectorias laborales de jóvenes realizado en la misma área geográfica y durante el mismo periodo.","palabras_clave":"JOVENES|DESEMPLEO|TRAYECTORIAS LABORALES|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18863,"idioma_id":4,"titulo":"In vitro assay for pre-screening resistance to Fusarium head blight in durum wheat","resumen":"      Fusarium head  blight (FHB), caused by Fusarium  graminearum Schwabe, is a wheat disease that causes yield losses and  mycotoxin accumulation in the grain. In durum wheat (Triticum turgidum L.  ssp.durum)  germplasm, genetic variability for resistance is scarce. To develop an improved  assay for FHB resistance in wheat, we evaluated the effect of F. graminearum inoculation on seed  germination and seedling growth and the relationship of these parameters with disease  severity following inoculation with the pathogen. For this we examined a genotype  set comprising ten durum wheats as well as two common wheats, including susceptible and introgressed resistant lines. Genotypes were additionally  screened using molecular markers linked to known FHB resistance QTLs. Significant differences were detected among  inoculated genotypes for germination, coleoptile length, coleoptile weight,  root weight and disease severity. Seedling variables were shown to be correlated  across experiments validating repeatability of the in vitro assay. Using multiple regression analysis, coleoptile length was significantly correlated with FHB severity (p &lt; 0.05) and explained 63% of head disease. Compared  to controls, introgressed genotypes carrying resistance alleles\/QTLs when  inoculated had nil or only slight reductions in seedling growth, and lower  disease severities than the corresponding original genotypes, suggesting that  seedling test can detect genetic differences in FHB resistance. Two genotypes  performed well in the seedling assay and also demonstrated low disease severity  even though they lacked the targeted QTLs, suggesting they harbor resistance  genes not screened herein. Based on relative coleoptile  length and Fisher statistical  significance, a ranking of genotypes consisting of three groups  with best, intermediate and poorest performance in relation to fungal  effect was established. The  advantageous features of this method reside in its statistical basis and  predictive ability of head disease. This study describes an in vitro assay that allows for rapid and  early determination of resistance\/susceptibility to F. graminearum, suitable for evaluating  germplasm collections or segregating progenies.   ","palabras_clave":"Fusarium graminearum|FHB|scab| in vitro screening|Triticum turgidum ssp. durum"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18864,"idioma_id":4,"titulo":"Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria","resumen":"Five dammarane-type triterpenoids, five pentacyclic triterpenoids (three of them carrying a carboxylic acid group), and two aromadendrane-type sesquiterpenoids were isolated from an Argentinian collection of the liverwort Lepidozia chordulifera. Compounds were characterized by comparison of their spectral data with those previously reported and tested in their ability to control bacterial growth, biofilm formation, bacterial Quorum Sensing process (QS), and elastase activity of Pseudomonas aeruginosa, as well as bacterial growth and biofilm formation of Staphylococcus aureus. The key role played by biofilm and elastase activity in bacterial virulence make them a potential target for the development of antibacterial agents. The aromadendrane-type sesquiterpenoid viridiflorol was the most potent biofilm formation inhibitor, producing 60% inhibition in P. aeruginosa and 40% in S. aureus at 50 &#956;g\/ml. Ursolic and betulinic acids (two of the pentacyclic triterpenoids isolated) were able to reduce 96 and 92% the elastase activity of P. aeruginosa at 50 &#956;g\/ml, respectively. Among the analyzed triterpenoids, those that carry a dammarane skeleton were the most potent inhibitors of the P. aeruginosa biofilm formation and were active against both P. aeruginosa and S. aureus. Subsequently, a computer-assisted study of the triterpenoid compounds was carried out for a better understanding of the structure-activity relationships.","palabras_clave":"Biofilm|Elastase|Lepidozia chordulifera|Pseudomonas aeruginosa|Staphylococcus aureus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18865,"idioma_id":4,"titulo":"Akt\/PKB: ONE KINASE, MANY MODIFICATIONS","resumen":"Akt\/PKB, a serine\/threonine kinase member of the AGC family of proteins, is involved in the regulation of a plethora of cellular processes triggered by a wide diversity of extracellular signals and thus considered a key signaling molecule in higher eukaryotes. Deregulation of Akt signaling is associated with a variety of human diseases, revealing Akt-­&#8208;dependent pathways as an attractive target for therapeutic intervention.  Since its discovery at the early 90?s, a large body of work has focus on Akt phosphorylation on two residues, threonine 308 and serine 473, and modification on these two sites has been established as equivalent to Akt activation. More recently, Akt has been identified as a substrate for many different post translational modifications, including not only phosphorylation of other residues but also acetylation, glycosylation, oxidation, ubiquitination and SUMOylation. These modifications could provide additional regulatory steps for fine tuning Akt function, Akt trafficking within the cell and\/or for determining the substrate specificity of this signaling molecule. In this review we will provide an overview of these different post translational modifications identified for Akt, focusing in their consequences on this kinase activity.","palabras_clave":"AKT|POST-TRANSLATIONAL MODIFICATION|PROTEIN FUNCTION|SIGNAL TRANSDUCTION|PROTEIN KINASE B"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18866,"idioma_id":4,"titulo":"TRACE ELEMENT CONCENTRATIONS IN COMMERCIAL GLUTEN-FREE AMARANTH BARS","resumen":"            Gluten-free foods are  specially designed to be consumed by people who suffer from celiac disease or  some type of gluten intolerance. Few studies are currently available about  trace element contents in gluten-free foods. This study aimed at analyzing the concentrations  of 15 trace elements in commercial gluten-free amaranth bars by inductively  coupled plasma optical emission spectrometry, after wet digestion by microwave  system. The accuracy of the method was determined by the use of a standard  reference material (NIST SRM 1570a Spinach Leaves) and recovery experiments,  obtaining satisfactory values in all cases. The contents of the investigated  trace elements in gluten-free amaranth bars were found to be in the range: Al  (3.7-8.1 µg\/g), Co (0.02-0.07 µg\/g), Cr (0.05-0.25 µg\/g), Cu (1.80-6.12 µg\/g),  Fe (7.0-14.5 µg\/g), Mn (6.5-10.6 µg\/g), Ni (0.30-0.78 µg\/g), Pb (0.25-1.12  µg\/g), Sr (1.4-2.7 µg\/g), and Zn (4.7-9.8 µg\/g). Some of the essential trace  elements were found to have good nutritional contribution in accordance to  daily nutrient recommendations for adults. The concentrations of non-essential  elements such as Al, Ni and Sr, were very low in all samples. The levels of  toxic elements such as As, Cd, Sb and Tl were not detected in any of the  samples, and do not pose any threat to consumers. However, the Pb  concentrations were above the safety limits in 8.9% of the studied samples. Therefore,  regular monitoring of this toxic metal should be conducted in the future, to  ensure the quality of the gluten-free products for human health.  ","palabras_clave":"SNACKS|PSEUDO-CEREALS|ICP-OES|NUTRITION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18867,"idioma_id":4,"titulo":"IMPACT OF PORCINE EPIDEMIC DIARRHEA ON PERFORMANCE OF GROWING PIGS","resumen":"The impact of porcine epidemic diarrhea virus (PEDv) infection on the US pork industry has mainly been attributed to the mortality that it causes in suckling piglets, and, consequently, much effort has been invested in the quantification of its effect in sow farms. However, no information on the performance of surviving pigs that were exposed to the PEDv as piglets is available. Here, a retrospective cohort study to evaluate the impact of porcine epidemic diarrhea virus (PEDv) infection on growing pigs' performance, as indicated by mortality, average daily gain (ADG), average daily feed intake (ADFI), and feed conversion ratio (FCR) was performed using production records from weaned pigs in nursery and wean-to-finish sites from sow farms that became PEDv-infected between May 2013 and June 2014. Production records from the first batch of growing pigs weaned in infected flows after the PEDv outbreak ('infected batches') were compared with those from pigs weaned within the previous 14 to 120 days ('control batches'). Performance records from infected and control batches, paired by flow, were compared using non-parametric paired tests. Mortality, ADG and FCR were significantly different in PEDv-positive (infected) compared with PEDv-negative (control) batches, with a mean increase of mortality and FCR of 11% and 0.5, respectively, and a decrease of ADG of 0.16 lb\/day. Our results demonstrate a poorer performance of growing pigs weaned after a PEDv outbreak compared with those weaned within the previous 14-120 days, suggesting that in addition to the mortality induced by PEDv in suckling pigs, the disease also impairs the performance of surviving pig. These findings help to quantify the impact of PEDv infection in the US and, ultimately, contribute to efforts to quantify the cost-effectiveness of disease prevention and control measures.","palabras_clave":"PORCINE EPIDEMIC DIARRHEA |IMPACT |PERFORMANCE|GROWING|PIGS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18868,"idioma_id":4,"titulo":"ASSOCIATION OF THE PRESENCE OF INFLUENZA A VIRUS AND PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS IN SOW FARMS WITH POST-WEANING MORTALITY","resumen":"Influenza A virus (IAV) and porcine reproductive and respiratory syndrome virus (PRRSV) are amongthe most important pathogens affecting pigs worldwide. Their effect on post-weaning mortality can besubstantial and may be potentiated by other concomitant factors. Here, the objective was to evaluatethe association between IAV and PRRSV infection at weaning with post-weaning mortality observed inwean-to-finish farms in order to better quantify the full impact of their presence in breeding herds.IAV and PRRSV presence was assessed by real time reverse transcription (RRT)?PCR on oral fluid sam-ples from suckling piglets in nine sow farms. Production data from 177 batches of growing pigs weanedone week before\/after IAV and PRRSV testing were analyzed to measure the association between IAVand\/or PRRSV test results and mortality recorded for a given batch through the use of Bayesian mixedeffects negative binomial multivariable regression model. The model accounted for potential confounderssuch as flow, date at weaning, days on feed and batch size. A statistically important association betweenIAV (incidence ratio (IR) = 1.18, 95% posterior probability interval 1.15?1.21) and PRRSV (IR = 1.41, 95%PPI 1.30?1.52) with post-weaning mortality was detected, with season and number of days on feed alsoassociated. Our results suggest that infection with IAV or PRRSV in the pre-weaning period is associatedwith an increase in post-weaning mortality. This association should be taken into consideration whenmeasuring the impact of IAV and PRRSV in breeding herds.","palabras_clave":"Swine|Influenza A virus|Porcine reproductive and respiratory syndrome virus|Post-weaning mortality|Bayesian modeling"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18869,"idioma_id":4,"titulo":"Salt Glands in the Poaceae Family and Their Relationship to Salinity Tolerance","resumen":"The Poaceae is one of the most important Angiosperm families, in terms of morphological diversity, ecology and economic importance. Species within this family show a very wide variation in terms of salinity tolerance. Salt secretion through salt glands plays a significant role in regulating ion balance, contributing to salinity tolerance. This review focuses on salt glands in the Poaceae family and their role in the salinity tolerance. In Poaceae microhairs have been observed in all subfamilies, except Pooideae, but functioning salt glands are reported only in genera belonging to the Chloridoideae subfamily. Structural, ultrastructural and physiological features of salt glands are summarized and discussed and the use of salt glands as potential target features for improving salt tolerance of crops is considered.","palabras_clave":"Salt gland|Poaceae|microhairs|salinity tolerance"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18870,"idioma_id":4,"titulo":"Effect of Hydrogen in Adsorption and Direct   Dissociation of CO on Fe (100) Surface: A   DFT Study","resumen":"Density functional theory was employed to investigate the effect of the hydrogen in the adsorptionand direct dissociation of CO on Fe (100) surface. The preadsorption of hydrogen with coveragesof 0, 1\/3 and 2\/3 monolayer (ML) was used in the present investigation. In the case of 1\/3 ML ofhydrogen, two configurations of adsorption were studied. The presence of hydrogen shows a ma-jor transference of electronic density from Fe surface to CO adsorbed, increasing the adsorptionenergy of CO from 2.00 eV in clean surface, to 2.76 eV in 2\/3 ML of hydrogen. Furthermore, the ac-tivation barrier for direct dissociation of CO was 1.13 eV and for the recombination energy 2.28 eVon clean Fe (100) surface. In the same way, the activation barrier for CO in the presence of coad-sorbed hydrogen was slightly affected presenting values of 1.06 eV and 1.16 eV to 1\/3 ML configu-rations and 0.98 eV for 2\/3 ML of hydrogen. Finally, the recombination energy decreases to 1.63eV and 1.49 eV for 1\/3 ML configurations and to 1.23 eV for 2\/3 ML of coadsorbed hydrogen. Theseresults indicate that the CO adsorption and dissociation are favored in the presence of hydroge-nated surfaces.","palabras_clave":"adsorption|dissociation|density functional theory|calculations"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18871,"idioma_id":4,"titulo":"Influence of coadsorbed H in CO dissociation and CH n formation on Fe (100): A DFT study","resumen":"Density Functional Theory (DFT) was employed to study the influence of coadsorbed hydrogen in CO dissociation and C hydrogenation on Fe(100). The formation of species CHn (n = 1, 2, 3) from the reaction CHn&#8722;1 + H as well as CO dissociation was analyzed in terms of hydrogen coverage. The active sites for the adsorption and reaction of each intermediate product on the catalytic surface and the reaction pathways of the products were determined. Mulliken population analysis was carried out to evaluate the charge transfer in the CHn\/Fe system. It was observed that carbon transfers charge in all cases, while the catalyst transfers charge principally in the adsorption of CH2 and CH3. To determine the effect of hydrogen on CO dissociation and CHn formation, coverages of 0, 0.25, 0.50 and 0.75 monolayers of hydrogen were employed. The CO adsorption energy shows slight variations in the presence of hydrogen, while in CO dissociation the variations of the barriers were negligible. In CHn adsorption, slight changes in the energies were observed. The reaction of C hydrogenation exhibited sensitivity to the presence of hydrogen, showing that CH and CH2 formation were endothermic processes, while CH3 formation showed an exothermic or endothermic behavior, depending on the final adsorption configuration.","palabras_clave":"heterogenous catalysis|fischer tropsch|coadsorption|DFT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18872,"idioma_id":4,"titulo":"Vitamin D Analogue: Potent Antiproliferative Effects on Cancer Cell Lines and Lack of Hypercalcemic Activity.","resumen":"The active form of vitamin D3, 1&#945;,25(OH)2D3, plays a major role in maintaining calcium\/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when effective antitumor doses are used. It has therefore been found necessary to synthesize new analogues that retain or even increase the antitumor effects but preclude hypercalcemia. This report presents the synthesis of a novel Gemini vitamin D analogue (UVB1) and its biological evaluation. We demonstrate that this compound has potent antitumoral effects over a wide panel of tumor cell lines while showing lack of hypercalcemic activity and toxicity effects in in vivo assays.","palabras_clave":"ANTIPROLIFERATIVE AGENTS|ANTITUMOR ACTIVITY|CANCER TREATMENT|GEMINI|CELL LINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18873,"idioma_id":4,"titulo":"On the irregular part of V-statistics multifractal spectra for systems with non-uniform specification","resumen":"Let (X,f) be a dynamical system with X a compact metric space. Let X^{r} be the product of r-copies of X, r&#8805;1, and &#934;:X^{r} &#8594;R. The multifractal decomposition for V-statistics for &#934;,f is defined as    E_{&#934;,f}(&#945;)={x:lim_{n&#8594;&#8734;}(1\/(n^{r}))&#8721;_{0&#8804;i&#8321;,...,i_{r}&#8804;n-1}&#934;(f^{i&#8321;}(x),...,f^{i_{r(x))=&#945;}.    The set of points x&#8712;X, for which the limit does not exist is called the irregular part, or historic set, of the spectrum. In this article we analyze the irregular part of the V-statistics for systems satisfying a weak form of the known Bowen specification property, called the non-uniform specification property. This concept was introduced by P. Varandas and allows to work in a nonuniformly hyperbolic context.","palabras_clave":"NON-UNIFORM SPECIFICATION|V-STATISTICS|MULTIFRACTAL SPECTRA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18875,"idioma_id":5,"titulo":"Evaluación del efecto de Saccharomyces cerevisiae sobre E coli en la cría de pollos","resumen":"Objetivos. Verificar la acción aglutinante de Saccharomyces cerevisiae sobredistintos géneros bacterianos y sobre E coli aisladas de materia fecal deanimales alimentados con y sin aditivos de Saccharomyces cerevisiae in vitro.Material y métodos. Se estudio la propiedad de aglutinación de E. coli yPseudomonas aeruginosa y de E coli aisladas de pollos alimentados con y sinaditivos, de Saccharomyces cerevisiae con la técnica de aglutinación enportaobjetos y observación microscópica.Resultados. Las E coli aisladas fueron positivas a la aglutinación in vitro y seobservó la reducción en el número de bacterias entéricas totales en el grupo deanimales tratados con aditivo con respecto al grupo no tratado.Conclusiones. En este estudio se demostró la capacidad de Saccharomycescerevisiae de aglutinar cepas bacterianas in vitro. La reducción en el númerode bacterias entéricas totales en el grupo de animales tratados con respecto algrupo control, sugiere que un fenómeno similar se estaría produciendo in vivo,evitando probablemente la unión de las bacterias a la pared intestinal.","palabras_clave":"prebiótico|polisacáridos bacterianos| suplementos dietéticos|pollos ( DeCs)"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18876,"idioma_id":4,"titulo":"Automatic design of interpretable fuzzy predicate systems for clustering using self-organizing maps","resumen":"In the area of pattern recognition, clustering algorithms are a family of unsupervised classifiers designed with the aim to discover unrevealed structures in the data. While this is a never ending research topic, many methods have been developed with good theoretical and practical properties. One of such methods is based on self organizing maps (SOM), which have been successfully used for data clustering, using a two levels clustering approach. Newer on the field, clustering systems based on fuzzy logic improve the performance of traditional approaches. In this paper we combine both approaches. Most of the previous works on fuzzy clustering are based on fuzzy inference systems, but we propose the design of a new clustering system in which we use predicate fuzzy logic to perform the clustering task, being automatically designed based on data. Given a datum, degrees of truth of fuzzy predicates associated with each cluster are computed using continuous membership functions defined over data features. The predicate with the maximum degree of truth determines the cluster to be assigned. Knowledge is discovered from data, obtained using the SOM generalization aptitude and taking advantage of the well-known SOM abilities to discover natural data grouping when compared with direct clustering. In addition, the proposed approach adds linguistic interpretability when membership functions are analyzed by a field expert. We also present how this approach can be used to deal with partitioned data. Results show that clustering accuracy obtained is high and it outperforms other methods in the majority of datasets tested.","palabras_clave":"Self-organizing maps|Clustering|Fuzzy logic|Fuzzy predicates|Degree of truth"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18877,"idioma_id":5,"titulo":"?Estructura productiva y reproducción de la fuerza de trabajo: la vigencia de los limitantes estructurales de la economía argentina?","resumen":"El artículo propone analizar la evolución del mercado del trabajo argentinoa la luz de las características estructurales de nuestro país.   Los capitales en Argentina presentan un rezago productivo creciente en relación a las condiciones medias de producción a nivel mundial por lo que requieren de fuentes de compensación para poder sobrevivir. Históricamente, este papel lo ha cumplido la renta de la tierra. Sin embargo, producto de las transformaciones ocurridas a escala mundial a mediados de los setentay del rezago creciente, la venta de la fuerza de trabajo por debajo de su valor y, coyunturalmente,el endeudamiento externoaparecen como fuentes complementarias. Así, las notables mejoras de los indicadores económicos y los laborales luego de la crisis de 2002, están sustentadas en salarios reales por debajo de sus mejores valores históricos y un flujo de renta nunca antes registrado. Es esto lo que explica que algunas variables no hayan podido recuperar los mejores valores históricos, a pesar del crecimiento reciente.","palabras_clave":"ESTRUCTURA PRODUCTIVA|VALOR|RENTA DE LA TIERRA|SALARIO REAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18878,"idioma_id":4,"titulo":"Biological nitrogen fixation in soybean in Argentina: relationships with crop, soil, and meteorological factors","resumen":"Aims  This study aims to (i) asses the contribution of biological N fixation (%Ndfa) in the soybean production area of Argentina, (ii) build a model for predicting %Ndfa using crop, soil, and meteorological variables, and (iii) estimate %Ndfa at the country level using values obtained in this study.  Methods  %Ndfa was assessed in paddocks and experimental plots located in an area 22?39° S and 56?66° W. %Ndfa was determined using the natural 15N abundance method. A complete data set of soil and meteorological variables (n?47) was used to develop a model for predicting %Ndfa.  Results  A median value of %Ndfa in aboveground biomass of 60 % (interquartile range 46?71 %) was estimated. Larger %Ndfa values were observed in areas with high crops yields. When seed yield was above 3.7 Mg ha&#8722;1, effective rainfall during fallow and mean temperature in the seed-filling period explained %Ndfa. Below 3.7 Mg ha&#8722;1, soil phosphorus content, pH, and effective rainfall in the vegetative period explicated %Ndfa.  Conclusions  Soybean production systems in Argentina showed larger %Ndfa than reported values in literature that may affect global N balances. Identified soil and meteorological variables may be useful for predicting %Ndfa in future studies, taking into account their spatial variation in the soil-plant system.  Keywords  Soybean BNF Nitrogen Argentina","palabras_clave":"Soybean|BNF|Nitrogen|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18879,"idioma_id":5,"titulo":"MICROABRASIÓN DE ESMALTE DENTARIO EN ODONTOLOGÍA RESTAURADORA","resumen":"La estética es el paradigma de la odontología restauradora. En la actualidad se utilizan procedimientos combinados por la exigencia sostenida de los pacientes por tener piezas dentarias blancas y brillantes. Es así que, para cumplir con esas expectativas clínicas, en algunos casos se utilizan técnicas de blanqueamiento dentario, mientras que en otros  se necesitan procedimientos como los de microabrasión o micro-macro abrasión para remover manchas oscuras o blancas del esmalte dentario buscando de esta manera la satisfacción en lo que a estética se refiere.  La microabrasión, es un procedimiento muy utilizado en la actualidad por los profesionales odontólogos por lo anteriormente expuesto o como técnica previa al uso de sistemas adhesivos.   Por lo anteriormente expuesto, se pretende con este documento presentar una revisión sobre conceptos actuales como así también los condicionantes al momento de seleccionar materiales o realizar el procedimiento de microabrasión.","palabras_clave":"microabrasión|abrasivos|estética|macroabrasión"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18880,"idioma_id":4,"titulo":"Co100-xFex magnetic thick films prepared by electrodeposition","resumen":"Co?Fe films are grown onto plane pre-treated Cu foils; the effects of the alloy composition on the morphology and the crystal texture of the electrodeposited films and their anisotropic magnetic hysteresis properties are explored. Nucleation and crystallization mechanisms in these Co-rich layers are also investigated  with pulse-reverse plating techniques, using the first cathodic pulse current?time transients. In  the diffusion controlled regime the deposition mechanism is found to involve progressive nucleation with  three-dimensional (3D) growth, except for the equiatomic Fe50Co50 solution where nucleation tends to  become instantaneous. The different morphologies and size scales observed are described and correlated  with coercivity. The films are electrodeposited onto electrochemically pre-treated Cu substrates from  feeds of nominal Fe\/Co mol ratios between 0\/100 and 50\/50. The composition of the deposited layers,  as determined by energy dispersive X-ray spectroscopy, are quite close to the nominal values. Cyclic voltammetry  determinations exhibit only a single reduction process on the cathode, indicating that a unique  (Co100xFex) phase grows. Depending on composition and on the substrate pre-treatment, these layers  exhibit textures with features of different sizes. X ray diffraction patterns indicate that the nanostructures  with Fe contents above 20 at.% crystallize in a body-centered cubic cell, while samples with Fe contents  below this value are fcc. Regarding the effect of composition on the morphology, Co and Co-rich  layers are compact, with large (100?300 nm) agglomerates of quite equiaxed, densely packed particles  (average 50 nm); as the iron content increases above 15 at.%, faceted particles 100 nm in size are  observed. All the electrodeposited layers are soft ferromagnetic at room temperature, with an in plane  easy axis; coercive fields\/forces between 10 mT and 71 mT are measured at 300 K.","palabras_clave":"Electrodeposition |Nanostructured layers|Nucleation| Growth mechanisms"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18881,"idioma_id":4,"titulo":"Ultra-small rhenium clusters supported on graphene","resumen":"The adsorption of very small rhenium clusters (2?13 atoms) supported on graphene was studied by high-angle annular dark field-scanning transmission electron microscopy (HAADF-STEM). The atomic structure of the clusters was fully resolved with the aid of density functional theory calculations and STEM simulations. It was found that octahedral and tetrahedral structures work as seeds to obtain more complex morphologies. Finally, a detailed analysis of the electronic structure suggested that a higher catalytic effect can be expected in Re clusters when adsorbed on graphene than in isolated ones.","palabras_clave":"RHENIUM|GRAPHENE|CATALYSIS|NANOPARTICLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18882,"idioma_id":4,"titulo":"Properties of NiMnGa alloys ultra rapidly solidified by suction casting","resumen":"Ni2MnGa alloys are obtained by suction casting in water chilled cylindrical copper moulds 50 mm long and 1-4 mm in diameter; the microstructure and the magnetic properties are then investigated as functions of the cylinder diameter. The solidification substructures are characterized by scanning electron microscopy and confocal microscopy. The martensitic transformation temperatures, determined by magnetization vs. temperature measurements, are lower than those measured in bulk Ni2MnGa single crystals (202 K). The demagnetization curves measured from saturation in the martensitic state show two steps: the first is at about+130 mT and the larger second one at relatively large inverse fields (about -300 mT), except in cylinders 4 mm in diameter, where these steps overlap at low inverse fields. These steps are likely to arise from a demagnetization mechanism involving field induced twin boundary motion in a few martensite variants, indicating a ferromagnetic shape memory effect in the cylinders.","palabras_clave":"Ni2MnGa alloy| Ultra rapid solidification| Magnetic shape memory |Martensític transformation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18883,"idioma_id":5,"titulo":"Dinámica del contenido de humedad de pastos y su relación con la ecología del fuego en región chaqueña occidental (Argentina)","resumen":"El fuego es un evento frecuente en la región chaqueña argentina. El contenido de agua (CH, %) es un factor que define la inflamabilidad de los combustibles vegetales y su dinámica temporal puede ser usada para comprender la ecología del fuego en una región, planificar su uso como prescripto; o como un indicador de riesgo para su prevención. En este trabajo se evaluó la dinámica de CH a través del tiempo en tres sitios ecológicos (&#8776; modelos de combustible) de la región chaqueña, en muestras con elionorus muticus como especie dominante (sitio bajo, sabana), Trichloris pluriflora y Pappopphorum pappipherum (sitio media loma, parques) y una especie exótica, Panicum máximum cv Gatton (sitio loma, bosque secundario rolado), respectivamente. El CH fue determinado en forma gravimétrica mensualmente en el bajo en 1992; y cada 10-15 días entre mayo 2008 y octubre 2009 en la media loma y la loma. Los datos fueron analizados en forma gráfica y mediante análisis de la varianza empleando estación climática, especie y tiempo cronológico como factores de clasificación. El CH promedio de las especies a través del tiempo presentó una amplitud estacional marcada, entre 4-5% en invierno-primavera y mayor al 150% en verano-otoño. Las especies nativas presentaron un CH significativamente menor que P. maximum y más bajo que el umbral de extinción teórico (CH=30%) indicando que en la región chaqueña, como en otros ecosistemas, las gramíneas y sus formaciones vegetales son el combustible por donde se propaga el fuego. La dinámica temporal de CH podría ser representada por una sinusoide. La correlación entre CH y la máxima humedad relativa entre fechas de muestreo fue significativa. Ambos resultados sugieren que es factible usar funciones matemáticas conocidas y métodos indirectos para predecir CH y la ?inflamabilidad? del combustible en las estaciones climáticas, facilitando la predicción del comportamiento de fuego","palabras_clave":"MANEJO DEL FUEGO|PASTIZALES|MODELOS DE COMBUSTIBLE|VEGETACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18884,"idioma_id":5,"titulo":"'Biocontrol con Trichoderma spp. de Fusarium oxysporum causal del ?mal de almácigos? en pre y post emergencia en cebolla'","resumen":"En Argentina, la ?podredumbre basal? y el ?mal de almácigos? causados por el complejo Fusarium spp.constituyen uno de los problemas más serios en cebolla. En este trabajo se estudió el uso de especies delgénero Trichoderma como agentes de control biológico (ACB) de F. oxysporum, causal del ?mal de almácigos?en cebolla. Se identificaron y caracterizaron morfológica, cultural y fisiológicamente a 10 aislamientos deTrichoderma spp. del cepario de Fitopatología. Por secuenciación del gen TEF-1&#945; se identificaron lasespecies de Trichoderma harzianum s.l. (7), T. atroviride (1), T. koningiopsis (1) y T. longibrachiatum (1). Losaislamientos nativos se compararon con una cepa de un biofungicida comercial (PHCTM T22, RootShield\/Plant Shield) en su capacidad antagonista de aislamientos de F. oxysporum. Se estudió in vitro elpotencial antagónico en cultivos duales y enfrentados. Además, se determinó la velocidad de crecimiento enplaca y la tolerancia a metabolitos volátiles producidos por Brassica oleracea. Aislamientos nativosseleccionados de Trichoderma y el comercial se evaluaron en ensayos de eficacia de biocontrol in vivo: (i) enalmácigo, aplicados sobre la semilla y (ii) en el trasplante, aplicados en raíces de plantines. Trichodermakoningiopsis (T13) y T. atroviride inhibieron en 50% al patógeno en cultivos duales. Sólo el crecimiento deTrichoderma sp. (T14) y del aislamiento comercial no fue afectado por los volátiles producidos por Brassicaoleracea. En el bioensayo de almácigo, el tratamiento de T. koningiopsis (T14) sobre las semillas y comoriego en suelo, consiguió el valor más alto de germinación de plántulas de cebolla (61%) y la mayorcolonización de las raíces de cebolla. Este mismo tratamiento aplicado en las raíces sobre plantines de 120días, produjo menor reducción de raíces afectadas de cebolla que con el aislamiento comercial.","palabras_clave":"ALLIUM CEPA|CONTROL BIOLOGICO|MAL DE ALMACIGOS|TRICHODERMA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18885,"idioma_id":4,"titulo":"A Cacti theoretical interpretation of the axioms of bialgebras and H-module algebras","resumen":"We establish a dictionary between the Cacti algebra axioms on a Cacti algebra structure with underlying free associative algebra, under suitable good behavior with degrees. Using these ideas, for an associative algebra A and a bialgebra H, we also translate Cacti algebra maps Omega \to C(A)(where Omega(H) stands for the cobar construction on H and C(A) is the Hochschild cohomology complex) with H-module algebra structures on A, and illustrate with examples of applications.","palabras_clave":"Cacti Operad|Hochschild cohomology|Cobar|Bialgebras"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18886,"idioma_id":4,"titulo":"Hip Height Measurements, Production and Reproduction in Adult Dairy Cows in Argentina Grazing Systems","resumen":"This study was aimed to characterize the measurement of the hip height as an indicator of body size,production and reproduction in dairy cows, kept in grazing systems in the Argentine humid Pampean region. Recordscorresponding to 210 third lactation Holstein cows, belonging to two dairies located on the area of Rosario city,Argentina, obtained in the period 2012-2013 were evaluated. The following variables were studied: milk yield (my),calving to conception interval (cci), number of services per conception (nsc) and hip height (hh). The results showedthat despite the significant differences (p&#8804;0. 05) in average height, which varied between 138 and 149 cm, animals didnot differ significantly in any of the productive and reproductive variables.  The results showed that adult cows coexistwith differences at the body structure level that would allow identifying different biotypes. The studied biotypesshowed no relation with production and reproduction levels.  A relation between production and reproduction wasfound. In this context, cows with less height would be the most appropriate for  milk production grazing systems inArgentine Pampas.","palabras_clave":"hip height measurements|production|reproduction|dairy cows|grazing systems"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18887,"idioma_id":4,"titulo":"On probe 2-clique graphs and probe diamond-free graphs","resumen":"Given a class G of graphs, probe G graphs are defined as follows. A graph G is probe G if there exists a partition of its vertices into a set of probe vertices and a stable set of nonprobe vertices in such a way that non-edges of G,whose endpoints are nonprobe vertices, can be added so that the resulting graph belongs to G. We investigate probe 2-clique graphs and probe diamond-free graphs. For probe 2-clique graphs, we present a polynomial-time recognition algorithm. Probe diamond-free graphs are characterized by minimal forbidden induced subgraphs. As a by-product, it is proved that the class of probe block graphs is the intersection between the classes of chordal graphs and probe diamond-free graphs.","palabras_clave":"2-clique graphs|diamond-free graphs|probe graphs"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18888,"idioma_id":4,"titulo":"Clique-perfectness of complements of line graphs","resumen":"A graph is clique-perfect if the maximum number of pairwise disjoint maximal cliques equals the minimum number of vertices intersecting all maximal cliques for each induced subgraph.  In this work, we give necessary and sufficient conditions for the complement of a line graph to be clique-perfect and an $O(n^2)$-time algorithm to recognize such graphs.  These results follow from a characterization and a linear-time recognition algorithm for matching-perfect graphs, which we introduce as graphs where the maximum number of pairwise edge-disjoint maximal matchings equals the minimum number of edges intersecting all maximal matchings for each subgraph.  Thereby, we completely describe the linear and circular structure of the graphs containing no bipartite claw, from which we derive a structure theorem for all those graphs containing no bipartite claw that are Class~2 with respect to edge-coloring.","palabras_clave":"clique-perfect graphs|edge-coloring|line graphs|matchings"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18889,"idioma_id":4,"titulo":"What season suits you best: seasonal light  changes and cyanobacterial competition","resumen":"Nearly all living organisms, including some bacterial species, exhibit biological processeswith a period of about 24 h called circadian (from the Latin circa, about and dies, day)rhythms. These rhythms allow living organisms to anticipate the daily alternation oflight and darkness. Experiments carried out in cyanobacteria have shown the adaptivevalue of circadian clocks. In these experiments, a wild type cyanobacterial strain (witha 24 h circadian rhythm) and a mutant strain (with a longer or shorter period) grow incompetition. In di\u000Berent experiments, the external light dark cycle was chosen to matchthe circadian period of the di\u000Berent strains, revealing that the strain whose circadian periodmatches the light-dark cycle has a larger tness. As a consequence, the initial populationof one strain grows while the other decays. These experiments were made under xedlight and dark intervals. In Nature, however, this relationship changes according to theseason. Therefore, seasonal changes in light could a\u000Bect the results of the competition.Using a theoretical model, we analyze how modulation of light can change the survivalof the di\u000Berent cyanobacterial strains. Our results show that there is a clear shift in thecompetition due to the modulation of light, which could be veried experimentally.","palabras_clave":"Cronobiologia |Cianobacterias|Ciclos circadianos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18890,"idioma_id":4,"titulo":"Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension","resumen":"Abstract  OBJECTIVE:  Inflammation has been proposed as a key component in the development of hypertension and cardiac remodeling associated with different cardiovascular diseases. However, the role of the proinflammatory cytokine interleukin-6 in the chronic stage of hypertension is not well defined. Here, we tested the hypothesis that deletion of interleukin-6 protects against the development of hypertension, cardiac inflammation, fibrosis, remodeling and dysfunction induced by high salt diet and angiotensin II (Ang II).  METHODS:  Male C57BL\/6J and interleukin-6-knock out (KO) mice were implanted with telemetry devices for blood pressure (BP) measurements, fed a 4% NaCl diet, and infused with either vehicle or Ang II (90&#8202;ng\/min per mouse subcutaneously) for 8 weeks. We studied BP and cardiac function by echocardiography at baseline, 4 and 8 weeks.  RESULTS:  Myocyte cross-sectional area (MCSA), macrophage infiltration, and myocardial fibrosis were also assessed. BP increased similarly in both strains when treated with Ang II and high salt (Ang II-high salt); however, C57BL\/6J mice developed a more severe decrease in left ventricle ejection fraction, fibrosis, and macrophage infiltration compared with interleukin-6-KO mice. No differences between strains were observed in MCSA, capillary density and MCSA to capillary density ratio.  CONCLUSION:  In conclusion, absence of interleukin -6 did not alter the development of Ang II-high salt-induced hypertension and cardiac hypertrophy, but it prevented the development of cardiac dysfunction, myocardial inflammation, and fibrosis. This indicates that interleukin-6 plays an important role in hypertensive heart damage but not in the development of hypertension.","palabras_clave":"IL-6|Hipertension|Daño de órgano blanco"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18891,"idioma_id":5,"titulo":"EFECTO DEL DÉFICIT DE GALECTINA-3 SOBRE EL REMODELAMIENTO VENTRICULAR POST-OCLUSION CORONARIA EN RATONES","resumen":"Background: Galectin-3 (Gal-3) is a lectin that regulates the immune response. However, its role in remodeling and ventricularfunction after myocardial infarction (MI) is unknown.Objective: The purpose of this study was to analyze whether Gal-3 deficit impairs remodeling and ventricular function afterMI in mice.Methods: Male Gal-3 KO mice and their respective C57 controls underwent anterior descending coronary artery ligation orsham operation. Animals were then divided into four experimental groups: 1) C57 sham; 2) Gal-3 KO sham; 3) C57 MI and4) Gal-3 KO MI. Seven days after surgery, an echocardiography was performed followed by euthanasia. Heart samples werecollected to measure MI size and fibrosis using Masson?s trichrome and picrosirius red, respectively, and assess macrophageinfiltration and IL-6 expression.Results: Left ventricular diameters were significantly increased in the C57 MI group compared with sham animals and theincrease was even higher in the Gal-3 KO MI group. Moreover, ejection fraction decreased to 47%±2% in C57 MI and 37%±3%in Gal-3 KO MI mice (p<0.02), and infarct size increased from 39.4%±5% in C57 MI to 66.8%±5% in Gal-3 KO MI animals(p=0.002). Macrophage infiltration and fibrosis in the MI area were significantly reduced in Gal-3 KO MI mice (p<0.001 C57MI vs. Gal-3KO MI) without changes of IL-6 concentration in the left ventricular free wall (p=ns).Conclusions: Gal-3 gene deletion is an important factor in repair kinetics, regulating macrophage infiltration and the degreeof fibrosis in the infarct area, as well as early remodeling after MI","palabras_clave":"Ventricular Remodeling| Galectin-3 -|Myocardial Infarction"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18892,"idioma_id":4,"titulo":"Creep behavior of ferritic steels after heat-treated","resumen":"The creep resistant ferritic steels have a microstructure with fine stable alloy carbides that impede the movement of thedislocations; however it is inevitable that during long periods of service or very critical conditions, microstructural changes occurthat are responsible for the loss of material strength.This type of steel is used for pressurized pipes, boiler tubes and heat exchangers at temperatures of up to 863 K. It exhibits goodmechanical strength at high temperature due to the precipitation of carbides but for the low content of chromium present lowcorrosion resistance at temperatures around 823 K.The objective of this work is to study the creep behavior of 1Cr 0.5Mo steel and compare the resistance when prior to service it issubjected to different heat treatments that improve its conditions of service.Tensile creep tests are performed at stresses between 131 and 205 MPa and temperatures between 843 and 923K.The microstructural variation of the original material is also analyzed, after heat treatment and test creep. Thereafter, some ofthese samples were selected for determining their chemical composition; light optical microscopy (LOM) and scanning electronmicroscopy (SEM). The micro hardness of the phases present in the different specimens is also measured.","palabras_clave":"Ferritic steel|creep|Mechanicals Properties"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18893,"idioma_id":4,"titulo":"Strong convergence of robust equivariant nonparametric functional regression estimators","resumen":"Robust nonparametric equivariant M-&#1048576;estimators for the regression function have been extensively studied when the covariates are in R^k. In this paper, we derive strong uniform convergence rates for kernel-based robust equivariant M&#1048576;regression estimator when the covariates are functional.","palabras_clave":"FUNCTIONAL DATA|KERNEL WEIGHTS| M-LOCATION FUNCTIONALS|ROBUST ESTIMATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18894,"idioma_id":4,"titulo":"Taq1B CETP Polymorphism and cardiovascular risk in an endogamous population of diabetic men: A study in Santa Rosa del Conlara, San Luis, Argentina","resumen":"ABSTRACTAims\/Introduction: Diabetic dyslipidemia is common in type 2 diabetes. TheTaqIBpolymorphism in cholesteryl ester transferprotein (CETP; B1 and B2 alleles; rs708272) isassociated with changes in enzyme activity and lipid concentrations. The aim of the present study was to assess associations ofCETPgenotypes with lipoprotein profile, oxidant\/anti-oxidant status and the plasma activityof paraoxonase-1 (PON-1) in a population ofdiabetic patients living in San Luis, Argentina.Materials and Methods: For oxidative stress status parameters, thiobarbituric acidreactive substances (TBARS) and nitric oxide (NO) levels, and catalase and PON-1 activitywere assessed in 40 patients with type 2 diabetes mellitus and 30 healthy participants.CETPpolymorphism was analyzed by polymerase chain reaction-based methods.Results: Type 2 diabetes mellitus had significantly higher concentrations of oxidativestress parameters: TBARS (P&lt;0.0001) and catalase activity (P&lt;0.0001). PON-1 activity andNO levels were significantly lower in diabetics (P=0.0002 andP=0.0008, respectively).TheCETPgenotypes distribution among study groups was not significantly different. TheB2 carriers of theTaqIB CETPpolymorphism are associated with higher high-density lipoprotein cholesterol levels and PON-1 activity in control and type 2 diabetes mellituspatients. Linear regression analysis showed that there was a significant and positivecorrelation between the changes of PON-1 activity and high-density lipoproteincholesterol levels in non-B1B1 (B2 carriers) in controls (r =0.83,P&lt;0.0001) and diabeticpatients (r =0.39,P=0.0003).Conclusions: The results of the current study showthat type 2 diabetes mellitus ischaracterized by intense oxidative stress, and that the alterations observed in the lipoprotein profile and PON-1 activity might be related to the higher CETP activity in diabeticpatients as a consequence of insulin resistance","palabras_clave":"Oxidative stress|Polymorphism|Type 2 diabetes mellitus|dyslipidemia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18895,"idioma_id":4,"titulo":"Identification and functional analysis of healing regulators in Drosophila","resumen":"Wound healing is an essential homeostatic mechanism that maintains the epithelial barrier integrity after tissue damage. Although we know the overall steps in wound healing, many of the underlying molecular mechanisms remain unclear. Genetically amenable systems, such as wound healing in Drosophila imaginal discs, do not model all aspects of the repair process. However, they do allow the less understood aspects of the healing response to be explored, e.g., which signal(s) are responsible for initiating tissue remodeling? How is sealing of the epithelia achieved? Or, what inhibitory cues cancel the healing machinery upon completion? Answering these and other questions first requires the identification and functional analysis of wound specific genes. A variety of different microarray analyses of murine and humans have identified characteristic profiles of gene expression at the wound site, however, very few functional studies in healing regulation have been carried out. We developed an experimentally controlled method that is healing-permissive and that allows live imaging and biochemical analysis of cultured imaginal discs. We performed comparative genome-wide profiling between Drosophila imaginal cells actively involved in healing versus their non-engaged siblings. Sets of potential wound-specific genes were subsequently identified. Importantly, besides identifying and categorizing new genes, we functionally tested many of their gene products by genetic interference and overexpression in healing assays. This non-saturated analysis defines a relevant set of genes whose changes in expression level are functionally significant for proper tissue repair. Amongst these we identified the TCP1 chaperonin complex as a key regulator of the actin cytoskeleton essential for the wound healing response. There is promise that our newly identified wound-healing genes will guide future work in the more complex mammalian wound healing response.","palabras_clave":"Wound healing|tissue repair|actins"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18896,"idioma_id":4,"titulo":"Is Ergodicity in an oxide glass ionic conductor a matter of time?","resumen":"From the results of molecular dynamic simulations of lithium metasilicate glass  at temperatures above and below their transition temperature (Tg )  we propose a simple graphical representation to search for the broken ergodicity in an ionic oxide glass. Knowing when ergodicity is lost is critical for the proper use of statistical mechanics as a tool for measuring dynamical and structural properties through molecular dynamic simulation. This work shows how an abrupt qualitative transformation occurs in the way the system explores its possible states when it goes down below the glass transition temperature range. We revise the broken ergodicity phenomena through its relationship with the observation time and the dynamic diversity of their atoms.","palabras_clave":"Broken ergodicity phenomena|Glass transition temperature|Molecular dynamic simulation|Lithium metasilicate glass"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18897,"idioma_id":4,"titulo":"Future sea level rise and changes on tides in the Patagonian Continental Shelf","resumen":"We investigate the effect of the future sea level rise (SLR) on the propagation of tides in the Patagonian Shelf by means of numerical simulations. Using a barotropic  implementation of the MARS model, we obtain solutions for scenarios which represent  the present condition and for potential future SLRs of 1, 2 and 10 m. The effect of  flooding of low-lying land areas is studied, and its influence on the propagation of tides in the region is discussed. Due to the coastal morphological features and the sense of propagation of the tidal wave in the Southern Hemisphere, inundation does not significantly modify the solution in the Patagonian Shelf; nevertheless, results are substantially changed in the much lower Northern Argentinean Shelf, north of 40º S, where dissipation is increased. The amplitude of M2 responds to SLR in a spatially non uniform manner. The response is non linear, particularly in the regions close to the amphidromic points. Tidal dissipation by bottom friction increases by 16% for the more extreme scenario consistently with a generalized increment of tidal amplitudes, and therefore currents, over the Patagonian Shelf. The changes in the extension and position of the tidal fronts are also explored. Results suggest that changes will be significant, with a reduction of the mixed areas in Cabo Blanco and San Sebastián and an increment of them in the vicinity of Península Valdés. The physical mechanisms which explain the observed modifications in the tidal regime are the changes with SLR of the speed of the tidal wave, the Rossby radius of deformation, the energy dissipation by bottom friction and the resonant properties of the basin. Similarly to numerical studies performed for other coastal areas of the world ocean, results indicate that important changes in the characteristics of the tides can occur if the SLR is large.","palabras_clave":"Patagonian Shelf|sea level rise|climate change|amphidromic points|tidal fronts|tides modeling."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18898,"idioma_id":5,"titulo":"Formación ética y ciudadana. Vicisitudes de la transformación curricular en la Patagonia argentina","resumen":"¿Qué tipo de educación ética y ciudadana ofrecen efectivamente las escuelas? En este artículo, se analizan las prescripciones curriculares de Formación Ética y Ciudadana en las escuelas de educación básica de la Patagonia argentina, y sus relaciones y contradicciones con las prácticas escolares de educación moral. Indaga el proceso de definición del área en el contexto de la reforma educativa de los años ?90 y busca reconstruir su modalidad de incorporación en el diseño curricular provincial de Santa Cruz, como expresión de las  intenciones explícitas e implícitas de esa política curricular. A través de grupos focales y entrevistas a docentes de diferentes escuelas públicas y privadas de tres localidades del norte santacruceño, se analizan las descripciones, valoraciones y expectativas de los docentes sobre sus prácticas de enseñanza en el terreno moral, como así también  las posibles causas de las distancias y contradicciones entre la políticas de enunciación curricular y las propuestas formativas que ofrecen las escuelas.","palabras_clave":"Etica|Educación ciudadana|Educación moral|curriculum"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18899,"idioma_id":5,"titulo":"Micorrizas vesículo-arbusculares, endófitos septados oscuros y anatomía radical en Fragaria ananassa var. Camino Real (Rosaceae), en la provincia de Tucumán","resumen":"En la provincia de Tucumán el cultivo de frutilla ocupa una superficie de 350 hectáreas. El mismo es invernal, con cosechas periódicas de fines de mayo a noviembre inclusive. Para evitar esta discontinuidad de producción, se incorporan al espectro de variedades precoces (Fortuna y Festival), variedades tardías, entre ellas Camino Real. Los objetivos de este trabajo fueron evaluar las micorrizas vesículo-arbusculares, los endófitos septados oscuros y caracterizar la anatomía radical en Fragaria ananassa var. Camino Real en cultivo comercial en la provincia de Tucumán. El muestreo fue realizado en el INTA-EEA Famaillá, Tucumán, Argentina. Se recolectaron los sistemas radicales correspondientes a un total de 20 individuos. Los que fueron tratados con técnicas convencionales. Los sistemas radicales de la variedad Camino Real presentan las células del parénquima cortical colonizadas por micorrizas vesículo-arbusculares con dos tipos morfológicos simultáneos: Arum y Paris, siendo la morfología Arum la de mayor frecuencia. Además, el tejido cortical presenta endófitos septados oscuros. La anatomía radical de la estructura primaria presenta una histología típica con estelas de tipo diarca a tetrarca. Mientras que la estructura secundaria de la raíz muestra diferentes estadios de crecimiento, con restos de epidermis y parénquima cortical adheridos a la polidermis en formación. Se describen por primera vez, para Argentina, las micorrizas vesículo-arbusculares, los endófitos septados oscuros y la anatomía radical en Fragaria ananassa var. Camino Real.","palabras_clave":"micorrizas arbusculares|septados oscuros|anatomía radical|Fragaria ananassa"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18900,"idioma_id":5,"titulo":"Crímenes anunciados: análisis de las coberturas mediáticas sobre femicidios en la Argentina","resumen":"En la Argentina, los medios masivos de comunicación han construido a lo largo de los años diferentes modos de exhibir el consumo del cuerpo de la mujer. Teorías críticas y teorías feministas han alertado sobre estas arquetipaciones y estereotipaciones estigmatizantes que ubican a la mujer en un lugar de recepción de diferentes tipos de violencias. En este artículo nos proponemos no solo pensar y analizar qué sucede con las coberturas mediáticas de diferentes casos de ?femicidios? que ocurrieron en los últimos años en la Argentina, sino también proponer analíticamente un modo de repensar las relaciones sociales de género en la cotidianeidad y en los medios masivos de comunicación. Pensamos que la perspectiva de género es central para poder desentrañar los vínculos de poder entre mujeres y varones y entre los medios masivos y la sociedad. Para ello realizaremos un recorrido con la intención de insistir en que no pueden hacerse lecturas, análisis, denuncias de los casos de femicidio si eso no conlleva una perspectiva de género acorde a los temas vinculados a la violencia social, incluso, puntualizar que las leyes aún resultan ambiguas a la hora de trabajar los crímenes de género. Las categorías y los casos que se estudiaron refieren a las búsquedas de las dos autoras en sus propias investigaciones vinculadas a la comunicación, la cultura y la problemática de género en la Argentina reciente que intentan dilucidar que, a veces, ciertas exposiciones referidas a la violencia de género no contemplan una perspectiva emancipadora del cuerpo de las mujeres, sino que, al contrario, intentan seguir manteniendo las relaciones desiguales y conservadoras resultantes del patriarcado. En este sentido, creemos que el modo de analizar la violencia de género es pensarla como una violencia social en su especificidad, con sus propias características y, fundamentalmente, no como un fenómeno que puede ser fácilmente consumido en el mercado mediático hegemónico.","palabras_clave":"FEMICIDIO|ARGENTINA|COMUNICACIÓN SOCIAL|CRÍTICA CULTURAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18901,"idioma_id":4,"titulo":"Synthesis and characterization of conjugated olygomers by acetone self-condensation end-functionalized with 4-hydroxycoumarin","resumen":" Abstract A conjugated olygomer with ending 4-hydroxycoumarin has been prepared by condensation of acetone using sulfuric acid as a catalyst. The resulting polymer was characterized by Matrix Assisted Laser desorption\/ionization Time-of-flight (MALDI-Tof) and Fourier Transformation Infrared Spectroscopy (FT-IR) methods. Keywords: acetone, 4-hydroxycoumarin, MALDI Tof, self-condensation, telechelic olygomers ","palabras_clave":"polymers|MALDI|EM|norHarmane matrix"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18902,"idioma_id":5,"titulo":"Aguas ajenas, tierras extrañas. Desigualdad hídrica al sur de la Cordillera de Los Andes en Mendoza (Argentina), a inicios del siglo XXI","resumen":"En Mendoza, el Valle de Uco ha sido elegido por grandes empresarios para la instalación de campos vitivinícolas irrigados con agua subterránea. Avalados por el Estado provincial por luchar contra el denominado desierto, el ingreso de estos empresarios modifica las áreas tradicionalmente irrigadas con agua superficial.Analizamos las políticas hídricas provinciales, la modificación de la estructura agraria y cómo productores locales atraviesan este proceso. Concluimos que hay una enajenación del agua, la tierra y la producción que sin embargo es difundida por el Estado como el triunfo del hombre frente al avance del desierto y la escasez hídrica.","palabras_clave":"Riego|Desigualdad|Identidades socio-culturales|Valle de Uco"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18903,"idioma_id":4,"titulo":"Altered Expression of Aromatase, Estrogen Receptors and Progesterone Receptors in Human Leydig Cell Hyperplasia","resumen":"Testicular function is regulated by pituitary hormones and also by paracrine and autocrine factors. A number of reports have pointed out the importance of estrogens and progesterone in male reproductive tract. Recently, we have reported in testicular biopsies from men with Sertoli Cell Only Syndrome (SCO) or Hypospermatogenesis (H) with Leydig cell hyperplasia (LCH) an increase in the expression of the TGFB1 and its receptors ALK1 and endoglin, which are involved in the proliferation of Leydig cells. The aim of the present work was to analyze the expression of aromatase, estrogen and progesterone receptors (ERs, PR) in pathological testicular biopsies with SCO or H with and without LCH. The ERs and CYP19 proteins were detected in the Leydig cells from all pathological biopsies analyzed. Biopsies with SCO or H with LCH showed an increment in the immunostaining of CYP19 and ERs in the Leydig cells respect to biopsies without LCH. The gene expression of CYP19 was increased in SCO or H biopsies with LCH respect to SCO and H biopsies without LCH. PR was localized in Leydig cells and showed a significant increment in biopsies with LCH respect from biopsies without LCH. The gene expression of both PRA and PRB was increased in biopsies with LCH respect to biopsies without LCH. In concussion, alterations in the gene expression of aromatase, ERs, and PR and the likely interactions of these systems with locally produced factors such as growth factors and cytokines, might lead to Leydig cell proliferation in testicular pathology.","palabras_clave":"AROMATASE |ESTROGEN|PROGESTERONE|LEYDIG"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18904,"idioma_id":5,"titulo":"Películas nanoestructuradas de polímeros hiperramificados como plantillas para la formación de estructuras metálicas","resumen":"La molécula Boltorn H30 es un polímero hiperramificado polihidroxilado de tercera generación de origen comercial con forma aproximadamente globular de diámetro promedio de 3.3 nm y tiene una cavidad endoreceptora que puede ser aprovechada para la incorporación de iones u otras moléculas pequeñas. En este caso, se analiza la adsorción espontánea de Boltorn H30 sobre sustratos de carbono para generar superficies nanoestructuradas capaces de captar o retener cationes cobre (II) en su interior. Posteriormente, las películas formadas se llevan a una celda electroquímica con el fin de reducir electroquímicamente el catión y generar estructuras metálicas usando el polímero hiperramificado como plantilla o molde. Las plataformas desarrolladas con cobre electrodepositado han mostrado ser útiles para la electrocatálisis de peróxido de hidrógeno. Las superficies estudiadas en este trabajo han sido caracterizadas mediante diferentes técnicas espectroscópicas, microscópicas y electroquímicas.","palabras_clave":"POLÍMERO HIPERRAMIFICADO|SUPERFICIES FUNCIONALIZADAS|CARBONO|COBRE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18905,"idioma_id":4,"titulo":"Absorption of waves by large-scale winds in stratified turbulence","resumen":"The atmosphere is a nonlinear stratified fluid in which internal gravity waves are present. These waves interact with the flow, resulting in wave turbulence that displays important differences with the turbulence observed in isotropic and homogeneous flows. We study numerically the role of these waves and their interaction with the large-scale flow, consisting of vertically sheared horizontal winds. We calculate their space- and time-resolved energy spectrum (a four-dimensional spectrum) and show that most of the energy is concentrated along a dispersion relation that is Doppler shifted by the horizontal winds. We also observe that when uniform winds are let to develop in each horizontal layer of the flow, waves whose phase velocity is equal to the horizontal wind speed have negligible energy. This indicates a nonlocal transfer of their energy to the mean flow. Both phenomena, the Doppler shift and the absorption of waves traveling with the wind speed, are not accounted for in current theories of stratified wave turbulence.","palabras_clave":"STRATIFIED FLOWS|WAVE TURBULENCE|CRITICAL LAYER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18906,"idioma_id":4,"titulo":"Trypanosoma cruzi trans-Sialidase Prevents Elicitation of Th1 Cell Response via Interleukin 10 and Downregulates Th1 Effector Cells","resumen":"The trans-sialidases (TSs) from Trypanosoma cruzi, the agent of Chagas disease, are virulence factors shed to the bloodstream that induces strong alterations in the immune system. Here we report that enzymatically active TS (aTS) or its lectin-like isoform (iTS) disturb CD4 T cell physiology inducing downregulation of Th1 cell functionality and in vivo cell-expansion. By using ovalbumin-specific DO11.10 cells as tracers of Th1-phenotype developing clones, we found that the infection induced significant amounts of IFN-&#947; but low IL-2 and increased IL-4 production in vivo, in agreement with a mixed T helper response. Production of cytokines associated with Th2-phenotype was prevented by passive transference of TS-neutralizing antibodies. TSs also reduced the T cell receptor signaling, assayed by Zap-70 phosphorylation.TSs also reduced IL-2 and IFN-&#947; secretion with a concomitant increased IL-4 production, then unbalancing the CD4 T cell response towards the Th2 phenotype. This effect was prevented withIL-10-neutralizing antibodies or by using IL10-\/- antigen-presenting cells, supporting the subversion of this regulatory pathway. In support, TSs stimulated IL-10 secretion by antigen-presenting cells during their interaction with CD4 T cells. When polarized cells were stimulated in the presence of TSs, secretion of IL-2 and IFN-&#947; was strongly downregulated in Th1 while IL-2 production was upregulated in Th2 cells. Although Th1 response is associated with host survival, it may simultaneously induce extensive damage to infected tissues. Thus, by delaying the elicitation of Th1-response and limit its effector properties, TSs restrain cell response supporting T. cruzi colonization and persistence while favoring host survival.","palabras_clave":"TRYPANOSOMA CRUZI|TRANS SIALIDASE|Th1 CELL RESPONSE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18907,"idioma_id":4,"titulo":"Use of computer vision to determine leaf damage caused by Diaphania hyalinata in Santiago del Estero, Argentina","resumen":"Diaphania hyalinata (L.) is a major pest of agriculture for cucurbits that causes different  percentages of defoliation. In this context and to determine precisely the consumed area  during the larval stage, we developed a method that uses computer vision techniques.  Programs use digitized images of the leaves before and after inserting the larvae to  determine the consumed area. The programs work with binarized and thresholded images,  first processing the leaf without damage, then the one that presents decrease in the  surface, and the damaged area is found by relating the constituent elements of each image.  Resulting values were similar to those mentioned and measured for this specie using other  techniques. It is considered an important contribution for its accuracy and short time spent  in processing.","palabras_clave":"computer vision|leaf damage|Diaphania hyalinata"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18908,"idioma_id":4,"titulo":"Correlation between martensitic phase transformation and magnetic Barkhausen noise of AISI 304 steel","resumen":"The movement of magnetic domain walls can be disturbed by material defects, also named pinning sites. When the magnetic  field is changing, the domain walls move by ?jumps? over these pinning sites. These jumps produce the so named magnetic  Barkhausen noise (MBN). During walls movements also low amplitude and high frequency elastic waves are generated, they are  called magnetic acoustic emission (MAE). Both MBN and MAE are technological and efficient alternatives of low cost in the  study of ferromagnetic materials which suffer degradation by plastic deformation, presence of inclusions, different stresses  configurations, etc., depending on their micro structural characteristics. For austenitic metastable stainless steel (no magnetic),  plastic deformation induces martensitic phase transformation (ferromagnetic). The aim of this work is to correlate the MBN with  the plastic deformation and martensitic phase transformation of AISI 304 stainless steel. Standard test samples were submitted to  uniaxial tensile strength with different load schedules up to rupture. At every instant the MBN produced was registered. Then  MBN was correlated with the steel microstructure when the martensitic phase was growing.","palabras_clave":"magnetic Barkhausen noise|austenitic steel|martensitic transfomation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18909,"idioma_id":4,"titulo":"Inhibitory Effect of the Hybrid Bacteriocin Ent35-MccV on the Growth of Escherichia coli and Listeria monocytogenes in Model and Food Systems","resumen":"Bacteriocins are being used as new food  biopreservative agents. In general, bacteriocins produced  by Gram-positive bacteria are active against other Grampositive.  Basically, the same principle applies to those produced  by Gram-negative bacteria. They have a restricted  spectrum of action against related bacteria to those that  produce the bacteriocin. Therefore, other hurdles or chemical  preservatives are necessary to apply to broaden the  spectrum of action of bacteriocins in foods. This is a further  and deeper study of the possible application of the hybrid  wide-spectrum bacteriocin named Ent35-MccV in food. Its  antimicrobial activity was assayed in skim milk and patties  as food models against Listeria monocytogenes and  Escherichia coli. The influence of the temperature and digestive  proteases on its biological activity and its antimicrobial  activity was tested in vitro on a variety of pathogenic  and food spoilage bacteria. The results showed that  Ent35-MccV could inhibit the growth of both the Grampositive  L. monocytogenes and the Gram-negative E. coli  in model food, and its activity was not affected by heating  conditions including autoclaving. E. coli strains and  Listeria spp. are the most affected bacteria, but Ent35-  MccV showed antimicrobial activity against some strain  of Salmonella spp., Staphylococcus epidermidis, Enterobacter  aerogenes, Morganella morgani, Proteus mirabilis,  Shigella boydii, Shigella flexneri, and Shigella sonnei.","palabras_clave":"MICROCIN|BACTERIOCIN|BIOPRESERVATION|HYBRID BACTERIOCIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18910,"idioma_id":4,"titulo":"BIOPRODUCTION  OF  RIBAVIRIN  BY  GREEN  MICROBIAL  BIOTRANSFORMATION","resumen":"Ribavirin is an antiviral compound widely used in   Hepatitis C Virus therapy. Biotransformation of this nucleoside analogue   using Escherichia coli ATCC 12407 as biocatalyst is herein   reported. Reaction parameters such as microorganism amounts, substrate   ratio and temperature were optimized reaching conversion yields of 86%.   Biocatalyst stability was enhanced by immobilization in agarose matrix.   This immobilized biocatalyst was able to be reused for more than 270&nbsp;h   and could be stored during more than 4 months without activity loss.   Batch and packed-bed reactors based on a stabilized biocatalyst were   assayed for bioprocess scale-up. A continuous sustainable bioprocess was   evaluated using a prototype packed-bed reactor, which allowed to   produce 95&nbsp;mg of ribavirin.  Finally, in this work an efficient green bioprocess for ribavirin bioproduction using a stabilized biocatalyst was developed.","palabras_clave":"BIOCATALYSIS|ANTIVIRAL AGENT|IMMOBILIZATION|SCALE-UP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18911,"idioma_id":4,"titulo":"Purification of substances from Achyrocline satureioides with inhibitory activity against Paenibacillus larvae, the causal agent of American foulbrood in honeybees larvae","resumen":"Abstract Achyrocline satureioides extracts were tested in vitro against the growth of  Paenibacillus larvae. Four different extracts were obtained by liquid-liquid extraction from  an aqueous-ethyl alcohol macerate of the aerial parts of the plant. The biological activity was  tested by the broth microdilution technique. Hexane extract showed the highest activity  (minimum inhibitory concentration=0.060±0.037 mg\/mL). Transmission electron microscopy  experiments showed that the main effect exerted by the hexane extract on the cell was at the  cellular membrane level. The hexane extract was analyzed by thin-layer chromatography, and  the activity of its components was tested by bioautography. Four growth inhibition zones were  observed in the bioautographic experiments (using hexane-acetone (7:3) as mobile phase),  with that at Rf=0.57 showing the largest zone of inhibition. High-performance liquid chromatographic  experiments, using ultraviolet and electrospray ionization coupled to tandem  mass spectrometric detection, showed the presence of one compound with a m\/z ratio of  442, which may be related to phloroglucinols &#945;-pyrone compounds recently discovered. The  high antibacterial activity of the hexane extract and of the isolated compound determined in  this work may be useful for the development of future new alternatives for the treatment of  American foulbrood.","palabras_clave":"Achyrocline satureioides .|Paenibacillus larvae .| Antibacterial activity . | Bioautography"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18912,"idioma_id":4,"titulo":"Ultradeformable phospholipid vesicles as a drug delivery system: a review","resumen":"Ultradeformable vesicles are highly deformable (elastic\/flexible) liposomes made of phospholipids plus highly mobile hydrophilic detergents capable of penetrating the intact skin across the stratum corneum and reach the viable epidermis. Ultradeformable vesicles are more effective than conventional liposomes in delivering drugs into and across the mammalian skin, and have been tested for local delivery of non-steroidal anti-inflammatory agents against musculoskeletal-articular disorders such as osteoarthritis, to treat atopic dermatitis, to deliver anti-infective drugs against epithelial infections and to avoid the first pass effect of oral antihypertensive drugs. Currently a single ultradeformable vesicle anti-inflammatory formulation has reached phase III clinical trials, but no commercial product based on this technology is yet available.","palabras_clave":"ELASTIC LIPOSOMES|ANTI-INFLAMMATORY AGENTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18913,"idioma_id":5,"titulo":"Estancamiento secular, Causas  Estructurales  del  Exceso  de  Ahorro Corporativo en Países Desarrollados","resumen":"Recientemente se inició un debate acerca de la hipótesis de `estancamiento secular´. Según esta hipótesis, la frágil situación económica imperante desde 2009 en los países industriales obedece a causas estructurales que impiden un crecimiento sostenible en el largo plazo.  El principal obstáculo estaría dado por el exceso de ahorro por sobre la inversión agregada en dichos países. Por su parte, un exceso de ahorro tendió a aparecer específicamente en el ámbito corporativo en los últimos años, aunque este hecho puntual es pasado por alto en la explicación predominante del `estancamiento secular´. En este trabajo mostramos la importancia del exceso de ahorro corporativo y exploramos dos hipótesis acerca de sus causas, a saber: que éste es ocasionado por el avance de la globalización económica y el progreso tecnológico desde 1980. La evidencia empírica analizada permite afirmar que se trata de dos hipótesis muy plausibles.","palabras_clave":"ahorro |inversión|sector corporativo|estancamiento"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18914,"idioma_id":5,"titulo":"División del trabajo y mecanismos de coordinación: Dinámica del desarrollo de los estudios del trabajo en la Argentina.  Una aproximación","resumen":"Las ciencias sociales latinoamericanas en general y los Estudios del Trabajo de la región enparticular, han recorrido diversas etapas a lo largo de su historia. La bibliografía existente y lasentrevistas llevadas a cabo a referentes de la disciplina sugieren que la agenda deinvestigaciones subcontinental se ha visto permeada por fenómenos macrosociales que fuerondelineando el clima social, político y económico de cada uno de los respectivos períodos. Desdeuna perspectiva histórica, este artículo se propone realizar un recorrido por el desarrollo de losEstudios de Trabajo en la Argentina dando cuenta de los diferentes mecanismos decoordinación y formas de ejercicio del trabajo sociológico preponderantes en cada una de susetapas de desarrollo.","palabras_clave":"Estudios del trabajo|Mecanismos de coordinación|División del trabajo."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18915,"idioma_id":4,"titulo":"Dielectric Permittivity Calculation of Composites Based on Electrospun Barium Titanate Fibers","resumen":"On the basis of theoretical predictions and experimental results, an empirical method using upper bound equation of the rule of mixtures (ROM) is reported to predict the dielectric permittivity of barium titanate nanofibers. In addition, composites with low volume fraction of BaTiO3 fiber layers embedded in epoxy resin were prepared and characterized. The relative permittivities of composites with perpendicular and parallel configurations, with respect to the electrodes, were calculated by means of the ROM model. The predicted permittivities matched precisely the obtained experimental values.","palabras_clave":"Polymer-matrix composites (PMCs) |Ceramic fiber|Electrical properties|Analytical modeling"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18916,"idioma_id":4,"titulo":"Redox Properties of Nanostructured Lanthanide- Doped Ceria Spheres Prepared by Microwave Assisted Hydrothermal Homogeneous Coprecipitation","resumen":"In this work, nanostructured LnxCe1-xO2-ä (Ln: Gd and Pr; x = 0.1 and 0.2) spheres weresynthesized by microwave assisted hydrothermal homogeneous co-precipitation and theirproperties were characterized by synchrotron radiation XRD, X-ray absorption near-edgespectroscopy (XANES) and scanning and high resolution electron microscopy (SEM andHRTEM). In situ XRD and XANES experiments were carried out under reducing andoxidizing conditions in order to investigate the redox behaviour of these materials. Thenanostructured mixed oxide spheres were found to have a cubic crystal structure (Fm3m space group). The spheres were composed of nanoparticles with an average crystallite size of about 10 nm. The Ln0.1Ce0.9O2-ä compositions exhibited the highest specific surface area (~60 m2g-1).In situ XRD experiments showed an increase in lattice parameters on reduction which wasattributed to the reduction of Ce4+ and Pr4+cations to Ce3+ and Pr3+, which have larger radii, and to the associated increase in VO concentration. This increase in lattice parameter was much more pronounced for PrDC than GDC, and was explained by the much larger change in ionic radius for Pr on reduction. XANES absorption experiments at the Ce and Pr L3-edge showed that the changes observed on reduction of the Pr-containing samples resulted mostly from the formation of Pr3+ rather than Ce3+, and supported the previously-reported proposal that Pr3+ has a stabilizing effect on Ce4+.","palabras_clave":"Lanthanide-doped ceria|redox properties|XANES|XRD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18917,"idioma_id":4,"titulo":"Immunohistochemical distribution of Early Pregnancy Factor in ovary, oviduct and placenta of pregnant gilts","resumen":"Early pregnancy factor (EPF) is an  immunosuppressant that promotes maternal immune system          tolerance of the allogenic fetus.  Little is known about localization of this factor in different tissues          and nothing has been reported  about localization in swine reproductive and placental tissues. We determined  the concentration of EPF in serum of gilts and porcine placenta conditioned  medium (PPCM). We also analyzed the expression of EPF in different reproductive  tissues of pregnant gilts at 10, 30, 60 and 90 days of pregnancy. EPF  concentration in serum and PPCM was determined by western blot and  densitometry. EPF expression in reproductive tissue was assessed by  immunohistochemistry. The highest concentration of EPF was observed at 30 days  in serum and PPCM; the concentration was higher in PPCM than in serum at the  stages we evaluated. All reproductive tissues from the gestational stages  analyzed showed specifi c labeling of EPF, but this labeling did not appear in  non-pregnant gilts. At 30 days pregnancy, the EPF expression in the ovary was predominantly  in follicular lutein cells, probably owing to its function as a luteotrophic  factor. In the oviduct, EPF was expressed in unciliated secretory epithelial  cells and in the cilia of ciliated cells. In the placenta, EPF was expressed in  the fetal portion (mesoderm chorioallantois and epithelium of endoderm). EPF  acts as an autocrine and paracrine growth factor for the trophoblast during the  peri-implantation period.","palabras_clave":"early pregnancy factor|immunolocalization|ovary|oviduct|placenta|swine"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18918,"idioma_id":4,"titulo":"In Vitro Toxicity Evaluation of Hydrogel Carbon Nanotubes Composites on Intestinal Cells","resumen":"          Composite materials based on carbon nanotubes (CNT) and polymeric hydrogels have become the subject matter of          major interest for use as carriers in drug delivery research. The aim of this study was to evaluate the in vitro cytotoxicity of the          hydrogel?carbon nanotube?chitosan (hydrogel?CNT?CH) composites on intestinal cells. Oxidized CNT were wrapped with chitosan          (CH), Fourier transform infrared (FT-IR) analysis suggest that oxidized CNT interact with CH. Transmission electron microscopy          (TEM) images show a CH layer lying around CNT. Chitosan wrapped CNT were incorporated to poly (acrylamide-co-acrylic acid)          hydrogels. Swelling behavior in buffers at different pH were evaluated and revealed a significantly lower swelling when it is exposed          to a acid buffer solution (pH 2.2). Mechanical properties were evaluated by measurements of elasticity and the material with CNT          showed better mechanical properties. The incorporation and liberation of Egg Yolk Immunoglobulin from hydrogel?CNT?CH were          also assessed and it revealed an improved performance. To evaluate the effect of these nanocomposites on cellular redox balance,          intestinal cells were exposed to hydrogel?CNT?CH composites and antioxidant enzymes were assessed. Cytotoxicity and apoptosis          were also evaluated. Hydrogel?CNT?CH composites induce no oxidative stress and there were no evidence of cytotoxicity or cell          death. These preliminary findings suggest that hydrogel?CNT?CH composites show improved properties and good biocompatibility          in vitro making these biomaterials promising systems for drug delivery purposes.","palabras_clave":"BIOCOMPATIBILITY|COMPOSITES|GELS|GRAPHENE AND FULLERENES|NANOTUBES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18919,"idioma_id":4,"titulo":"Dietary and anthropometric indicators of nutritional status in relation to  Helicobacter pylori  infection in a paediatric population","resumen":"It has been postulated that Helicobacter pylori infection could affect growth and appetite, consequently influencing body weight. Therefore, the association between H. pylori infection and the dietary and anthropometric indicators of nutritional status of a paediatric populationwere investigated. A total of 525 children (aged 4?16 years) who were referred to the gastroenterology unit of the Sor Maria Ludovica Children?s Hospital from Buenos Aires, Argentina, were enrolled and completed an epidemiological questionnaire. H. pylori infection wasdiagnosed using the 13C-urea breath test (13C-UBT). Height and weight were assessed for calculation of anthropometric indicators. Energy and macronutrient intakes were estimated by 24 h dietary recall. Data analysis was performed using a x 2 test, a Student?s t test, a Mann?Whitney U test and linear and logistic regressions. The prevalence of H. pylori infection was 25·1% (with a mean age of 10·1 (SD 3·1) years). A tendency towards lower energy, carbohydrate, protein and fat intakes was observed in infected patients; however, it was not associated with H. pylori infection in any of the evaluated age groups (4?8, 9?13 and 14?16 years). Underweight, stunting, overweight and obesity were also not associated with the infection. Although height-for-age and BMI-for-age Z scores tended to be lower in infected patients, thedifferences between H. pylori-positive and H. pylori-negative children were not statistically significant. In conclusion, H. pylori infection was not associated with dietary intake or with anthropometric indicators in the present population of children with gastrointestinal symptoms;however, an increased sample size would be needed to confirm the observed tendency towards lower dietary intake and lower anthropometric indicators of nutritional status in H. pylori-infected children.&nbsp;","palabras_clave":"Helicobacter pylori|Children|Dietary Intake|Anthropometric indicators"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18920,"idioma_id":5,"titulo":"EFECTOS DE LA IMPULSIVIDAD Y EL CONSUMO DE ALCOHOL SOBRE LA  TOMA DE DECISIONES EN LOS ADOLESCENTES","resumen":"Background: adolescence is a period associated with the onset  and  progression  of  alcohol  consumption.  At  this stage  are  also  frequent  impulsive  behaviors  and  risky decision-making (DM). Aim: To evaluate pattern of alcohol consumption (PAC) in male and female adolescents, their different  levels  of  impulsivity  and  how  these  variables affect decision-making. Methodology: Using a latent class analysis  several  PAC  of  230  adolescents  aged  14  to  17 years  were  determined.  Design:  A  prospective  ex  post facto crossover design with Positive Urgency (Low \/ High), PCA (Moderate \/ Binge) and Sex (Female \/ Male) as factors was used. DM was assessed in 78 participants who joined the  study  groups.  Results:  binge  male  consumers, compared  with  moderate,  performed  better,  but  their performance declined at the end of the test. Within the group  of  participants  with  low  positive  urgency,  those with  a  binge  PAC,  made  more  advantageous  DM. Conclusions: PAC and impulsivity trait appear to influence DM in adolescents.","palabras_clave":"Alcohol|Impulsividad|Adolescencia|Toma de Decisiones"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18921,"idioma_id":4,"titulo":"Single stage H2 production, purification and heat supply by means of Sorption-enhanced Steam Reforming of Glycerol. A thermodynamic analysis","resumen":"                          The effect of CO2 removal with CaO in the production and purification of fuel cell-grade H2 by glycerol steam reforming is studied from a thermodynamic point of view. Results obtained with the non-stoichiometric method show that CaO enables some improvements to the conventional steam reforming since four simultaneous processes take place at the same stage: H2 production, CO2 separation, CO elimination and heat supply: by separating the CO2 from the gaseous mixture, CaO also shifts the equilibrium towards the production of H2 compared to conventional reforming, and the operating temperature is lowered with respect to conventional steam reforming. The removal of CO2 not only enables higher H2 purity (close to 100% on dry basis) but reduces the amounts of CO as well. For temperatures below ca. 750K, a level lower than 20 ppm (on dry basis) can be reached, thus avoiding the need of a purification stage. Since the reaction of CaO with CO2 is exothermic, the heat is supplied within the reactor. Finally, it was found that the system behavior was strongly dependent on the presence of Ca(OH)2.This four-in-one process can be a way of enhancing the efficiency of the overall system of production-purification of H2.   ","palabras_clave":"GLYCEROL STEAM REFORMING|SORPTION-ENHANCED PROCESS|HIDROGEN PRODUCTION|PURIFICATION|PEM FUEL CELL|NON-STOICHIOMETRIC METHOD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18922,"idioma_id":4,"titulo":"Prenatal Exposure to Continuous Constant Light Alters Endochondral Ossification of the Tibiae of Rat Pups.","resumen":"Clinical and experimental studies suggest that prenatal exposure to stress can impact the growth and development of offspring. The effect of prenatal exposure to constant light, applied as a chronic stressor, on endochondral ossification of the tibiae of 3-day-old and 15-day-old pups was histomorphometrically evaluated. Pregnant rats were divided into 2 groups: mothers chronically exposed to a 12:12-hour light\/light cycle (LL) and control mothers maintained on a 12:12-hour light\/dark cycle on days 10-20 of pregnancy. On postnatal days 3 and 15, the pups were weighed and euthanized. The tibiae were resected and histologically processed to obtain sections for hematoxylin and eosin staining (HE) and tartrate-resistant acid phosphatase (TRAP) histochemistry, in order to perform histomorphometric determinations. The data were statistically analyzed. A significant decrease in hypertrophic cartilage thickness was observed in the tibiae of the 3-day-old (LL: 0.134 ± 0.02 vs.CONTROLS:0.209 ± 0.023 mm; p < 0.01) and 15-day-old (LL: 23.32 ± 3.98 vs.CONTROLS:22.96 ± 1.93 mm; p < 0.05) prenatally stressed pups. The subchondral bone volume was significantly lower in the tibiae of the 3-day-old LL pups (38.83 ± 6.14%) than in the controls (62.83 ± 10.67%; p < 0.01). The decrease in subchondral bone volume and hypertrophic cartilage thickness shows that the normal growth process of the tibia is impaired in prenatally stressed pups.© 2015 S. Karger AG, Basel.","palabras_clave":"PRENATAL STRESS|OSSIFICATION|BONE VOLUME|GROWTH PLATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18923,"idioma_id":4,"titulo":"Iterative double cyclization reaction by SRN1 mechanism. A theoretical interpretation of the regiochemical outcome of diazaheterocycles","resumen":"In this report, we present a synthetic and mechanistic study of novel iterative double cyclization intramolecular SRN1 reactions from diamides bearing two aryl iodide moieties. This cyclization affords aromatic diazaheterocyclic compounds in good yields. Two synthetic strategies were employed for their preparation: intramolecular SRN1 and Homolytic Aromatic Substitution. The mechanism is non-trivial and we propose that radicals are intermediates. The regiochemistry was studied using computational calculations, employing the DFT method and the B3LYP functional. It was found that the distribution of products depends on the cyclization activation energies, proportion of neutral conformers, and the type of the electron transfer reaction","palabras_clave":"Heterociclos|Transferencia Electrónica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18924,"idioma_id":4,"titulo":"Tidal effects on short-term mesozooplankton distribution in small channels of a temperate-turbid estuary, South West Atlantic","resumen":"The shortterm variability of mesozooplankton distribution in terms of geomorphology, dynamics and anthropogenic influence was examined in two differents channels of the Bahia Blanca Estuary (BBE) along two tidal cycles. All the physicochemical measurements and mesozooplankton sampling were performed at a fixed site during approximately 22-23h at 3h intervals. Pumps were used to obtain surface and bottom mesozooplankton samples and the water speed of each stratum was measured with an Acoustic Doppler Current Profiler (ADCP). In total, 23 mesozooplanktonic taxa belonging to four phyla (Arthropoda, Annelida, Echinodermata and Chordata) were identified. The most abundant taxa along the two tidal cycles were Balanus glandula larvae, Eurytemora americana and Acartia tonsa. A discernible variability in the water conditions was found in the two selected channels. Vertical mesozooplankton distribution was also found to vary along the tidal cycle in both channels in accordance with the channel´s geomorphology and dynamic characteristics. The variation of the abundace of the different taxa during ebb and flood currents might indicate the existence of a tidal vertical migration (TVM) of the mesozooplankton as a response to particular dynamic water conditions.","palabras_clave":"ZOOPLANKTON|ESTUARY|TIDAL CURRENTS|VERTICAL DISTRIBUTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18925,"idioma_id":4,"titulo":"Order Evolution in Iron-Based Alloys Viewed through Amplitude Dependent Damping Studies","resumen":"Amplitude dependent damping and neutron thermo-diffraction studies were performed in Fe-Al-Si, Fe-Al-Cr and Fe-Si alloys. Resultsshow that the behaviour of the strength of the amplitude dependent damping as a function of temperature is a suitable tool for determining theorder changes as a function of temperature. A decrease in the order degree leads to an increase in the strength of the amplitude dependentdamping, due to the dislocation mobility increases","palabras_clave":"order degree|dislocation mobility|iron-based alloys |amplitude dependent damping|neutron thermodiffraction"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18926,"idioma_id":4,"titulo":"Study of the inactivation of spoilage microorganisms in apple juice by pulsed light and ultrasound","resumen":"The aim of this study was to evaluate the effect of ultrasound (US) (600 W, 20 kHz and 95.2 mm wave amplitude; 10 or 30 min at 20, 30 or 44 ± 1 C) and pulsed light (PL) (Xenon lamp; 3 pulses\/s; 0.1 m distance; 2.4 J\/cm2e71.6 J\/cm2; initial temperature 2, 30, 44 ± 1 C) on the inactivation of Alicyclobacillus acidoterrestris ATCC 49025 spores and Saccharomyces cerevisiae KE162 inoculated in commercial (pH: 3.5; 12.5 Brix) and natural squeezed (pH: 3.4; 11.8 Brix) apple juices. Inactivation depended on treatment time, temperature, microorganism and matrix. Combination of these technologies led up to 3.0 log cycles of spore reduction in commercial apple juice and 2.0 log cycles in natural juice; while for S. cerevisiae, 6.4 and 5.8 log cycles of reduction were achieved in commercial and natural apple juices, respectively. In natural apple juice, the combination of US þ 60 s PL at the highest temperature build-up (56 ± 1 C) was the most effective treatment for both strains. In commercial apple juice, US did not contribute to further inactivation of spores, but significantly reduced yeast population. Certain combinations of US þ PL kept on good microbial stability under refrigerated conditions for 15 days.","palabras_clave":"ULTRASOUND |PULSED LIGHT|HURDLE TECHNOLOGY|FRUIT JUICES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18927,"idioma_id":4,"titulo":"Inactivation kinetics and growth dynamics during cold storage of Escherichia coli ATCC 11229, Listeria innocua ATCC 33090 and Saccharomyces cerevisiae KE162 in peach juice using aqueous ozone","resumen":"The effect of ozone (10 and 18 ppmin the gas supply) on the inactivation of Escherichia coli ATCC 11229, Listeriainnocua ATCC 33090 and Saccharomyces cerevisiae KE 162 inoculated in peach juice using a bubble column wasinvestigated. Microorganism growth dynamics in decontaminated juice during 14 days storage (5 ± 1 °C)were also assessed. The highest ozone concentration resulted in lower counts of E. coli ATCC 11229 duringmost part of the treatment; however, after 12 min exposure, coliform counts were reduced by approximately4.3 log-cycles in peach juice exposed to both ozone levels. L. innocua ATCC 33090 counts decreased 3.9 and 4.9log-cycles after a 12-min exposure using 10 or 18 ppm ozone, respectively. For S. cerevisiae KE162, the treatmentwas less effective and only 1 log-cycle of reduction was achieved regardless of ozone concentration. Nonlinearinactivation curves were successfully fitted with Weibull type and modified Coroller models. Growth dynamicsin ozone treated juice during cold storage depended on inoculated microorganism and ozone level applied, butsurviving microorganisms faced more difficulties to grow than in unprocessed juice, especially at the highestozone concentration. Ozone exposure (18 ppm) coupled with low temperature storage conditions seemed tobe a good option for preserving peach juice.Industrial relevance: Ozone processingwhich can be an alternative pasteurization technology has been studied forobtaining ready-to-drink ?fresh-like? juiceswith aminimumof nutritional, physicochemical, functional or organolepticchanges. Present results indicated that ozone exposure in a bubble column could reduce pathogenic microorganisms´populations and inhibited yeast growth in decontaminated peach juice.","palabras_clave":"ozone |inactivation kinetics|peach juice|Weibull and Coroller models|microorganism?s recovery"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18928,"idioma_id":4,"titulo":"Increase in Visibility of Light Signals","resumen":"Abstract   This work describes a study of perception of light signals used in aeronautics. Devices known as ?obstruction   light? (L-810 type, according to the Organization of International Civil Aviation OACI and the Federal Aviation   Administration FAA) with LED technology were fed with square pulses of voltage, attaining flashes with   imperceptible rise times. The lights were presented to observers, simulating the habitual vision  conditions  for   these devices.   With this diagram, perceptive comparisons for different flash frequencies were carried out, exploring especially   the transition zone between flickering and steady vision of light. The test showed that an important number of   people experienced a perceptive increase in such transition zone. The phenomenon, which can be related with to   Broca-Sulzer effect, could be used in order to improve the signal visibility.","palabras_clave":"VISUAL|PERCEPTION|PULSING|LIGHT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18929,"idioma_id":4,"titulo":"The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets","resumen":"In this review paper we aim at presenting the current knowledge on structural aspects of soluble lipid binding proteins (LBPs) found in parasitic helminths and to discuss their potential role as novel drug targets. Helminth parasites produce and secrete a great variety of LBPs that may participate in the acquisition of nutrients from their host, such as fatty acids and cholesterol. It is also postulated that LBPs might interfere in the regulation of the host&#1523;s immune response by sequestering lipidic intermediates or delivering bioactive lipids. A detailed comprehension of the structure of these proteins, as well as their interactions with ligands and membranes, is important to understand host-parasite relationships that they may mediate. This information could also contribute to determining the role that these proteins may play in the biology of parasitic helminths and how they modulate the immune systems of their hosts, and also towards the development of new therapeutics and prevention of the diseases caused by these highly pathogenic parasites.","palabras_clave":"LIPID BINDING PROTEINS|PARASITIC HELMINTHS|NEMATODES|FATTY ACIDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18931,"idioma_id":4,"titulo":"Dopamine bioavailability in the mPFC modulates operant learning performance in rats: An experimental study with a computational interpretation","resumen":"Abstract  Dopamine encodes reward and its prediction in reinforcement learning. Catechol-O-methyltransferase (COMT) activity in the medial prefrontal cortex (mPFC) has been shown to influence cognitive abilities by modifying dopamine clearance. Nevertheless, it is unknown how COMT in the mPFC influences operant learning. Systemic entacapone (50mg\/kg), as well as local entacapone (3 pg) and recombinant COMT (17 &#956;g) in the mPFC were administered to male Long Evans rats prior to training in an operant conditioning task. We found that systemic and local administration of the COMT inhibitor entacapone significantly improves learning performance. Conversely, recombinant COMT administration totally impaired learning. These data have been interpreted through a computational model where the phasic firing of dopaminergic neurons was computed by means of a temporal difference algorithm and dopamine bioavailability in the mPFC was simulated with a gating window. The duration of this window was selected to simulate the effects of inhibited or enhanced COMT activity (by entacapone or recombinant COMT respectively). The model accounts for an improved performance reproducing the entacapone effects, and a detrimental impact on learning when the clearance is increased reproducing the recombinant COMT effects. The experimental and computational results show that learning performance can be deeply influenced by COMT manipulations in the mPFC.","palabras_clave":"Computational model;|Dopamine; |Entacapone|Neural network"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18932,"idioma_id":4,"titulo":"Characterization of pectinase activity for enology from yeasts occurring in Argentine Bonarda grape","resumen":"Pectinolytic enzymes are greatly important in winemaking due to their ability to degrade pectic polymers from grape, contributing to enhance process efficiency and wine quality. This study aimed to analyze the occurrence of pectinolytic yeasts during spontaneous fermentation of Argentine Bonarda grape, to select yeasts that produce extracellular pectinases and to characterize their pectinolytic activity under wine-like conditions. Isolated yeasts were grouped using PCR-DGGE and identified by partial sequencing of 26S rRNA gene. Isolates comprised 7 genera, with Aureobasidium pullulans as the most predominant pectinolytic species, followed by Rhodotorula dairenensis and Cryptococcus saitoi. No pectinolytic activity was detected among ascomycetous yeasts isolated on grapes and during fermentation, suggesting a low occurrence of pectinolytic yeast species in wine fermentation ecosystem. This is the first study reporting R. dairenensis and Cr. saitoi species with pectinolytic activity. R. dairenensis GM-15 produced pectinases that proved to be highly active at grape pH, at 12 ºC, and under ethanol and SO2 concentrations usually found in vinifications (pectinase activity around 1.1 U\/mL). This strain also produced cellulase activity at 12 ºC and pH 3.5, but did not produce &#946;-glucosidase activity under these conditions. The strain showed encouraging enological properties for its potential use in low-temperature winemaking.","palabras_clave":"AUREOBASIDIUM PULLULANS|CRYPTOCOCCUS SAITOI|PECTINOLYTIC ACTIVITY|RHODOTORULA DAIRENENSIS|WINEMAKING TECHNOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18933,"idioma_id":4,"titulo":"Formation of Cu and Ni Nanowires by Electrodeposition","resumen":"In this work we analyzed the formation of Cu and Ni nanowires by electrodeposition inside alumina templates. The deposits were performed from CuSO4 + H2SO4 and NiSO4 + NiCl2 + H3BO3 + H2SO4 solutions for the electrodeposition of Cu and Ni, respectively. To allow the cations deposition, sufficiently negative potentials were used. The experience time was ranged between 500s and 1h. After the metal electrodeposition, the sample was immersed in NaOH to dissolve the alumina membrane and to expose the generated deposit. The obtained nanostructures were characterized by SEM (scanning electron microscopy) and EDX (energy dispersive microanalysis X-ray). Deposits were corresponded with nanowires having an average diameter of 300 nm. The length of the nanostructures was about 10 microns. EDX analysis confirmed the nature of deposits.","palabras_clave":"NANOWIRES|ELECTRODEPOSITION|ALUMINIUM OXIDE TEMPLATE|COPPER|NICKEL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18934,"idioma_id":5,"titulo":"Prevalence of Chlamydia trachomatis infection and factors with the risk of acquiring sexually transmitted infections in college students","resumen":"Resumen La infección genital por Chlamydia trachomatis es considerada en la actualidad una  de las causas más frecuentes de infecciones transmisibles sexualmente (ITS) a nivel mundial  y afecta principalmente al grupo de jóvenes menores de 25 anos. ? El objetivo de este estudio  fue determinar la prevalencia de la infección por C. trachomatis en alumnos ingresantes a la  Universidad Nacional del Sur (Bahía Blanca, Argentina) y evaluar los factores de riesgo para  la adquisición de ITS. Participaron en el estudio 204 jóvenes de edad media de 19 anos, ? que  remitieron una muestra de orina de primera micción y respondieron a una encuesta anónima.  La investigación de C. trachomatis se realizó sobre 114 muestras válidas mediante una técnica  de amplificación génica, cuyo blanco molecular es el gen ompA. Se detectaron 4 casos de infección  por C. trachomatis, lo que implicó una prevalencia del 3,5 %. Los factores de riesgo que  demostraron estar asociados con la adquisición de esta ITS fueron un historial de 7 o más parejas  desde el comienzo de las relaciones sexuales y el contacto con una nueva pareja sexual en  los últimos 4 meses. La prevalencia de infección por C. trachomatis reflejó una moderada circulación  de este microorganismo en la población estudiada. Si bien algunos aspectos revelados  en las encuestas sugieren una población de bajo riesgo para la adquisición de ITS en general,  otros datos evidencian lo contrario y alertan sobre la necesidad de incrementar la vigilancia y  desarrollar acciones de concienciación y prevención en esta población.","palabras_clave":"Infecciones sexualmente transmisibles|Chlamydia trachomatis|factores de riesgo|poblacion vulnerable para ITS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18935,"idioma_id":4,"titulo":"Milk fermented with selected strains of lactic acid bacteria is able to improve folate status of deficient rodents and also prevent folate deficiency","resumen":"Folate deficiencies are common in many parts of the world. The use of folate producing food grade microorganisms has been proposed as a more natural alternative to fortification with the chemical folic acid. The aim of this study was to evaluate the effectiveness of a novel fermented milk elaborated with adequately selected folate producing lactic acid bacteria. This product was tested using both a rodent depletion-repletion model and a complete deficient model. The folate bioenriched fermented milk was able to increase plasma folate concentrations and decrease homocysteine levels. This is the first report demonstrating that a naturally folate bio-enriched fermented milk, elaborated with folate-producing starter cultures, not only is effective to improve folate status but can also prevent folate deficiency. Consumers also would obviously benefit from this type of product because they could increase their folate intakes while consuming foods that form part of their normal diets.","palabras_clave":"FOLATE|VITAMIN DEFICIENCY|LACTIC ACID BACTERIA|RODENT MODELS|HOMOCYSTEINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18936,"idioma_id":5,"titulo":"Tipos de apoyo y la digitalización de las redes personales. El uso de Facebook de adolescentes rururbanos de Mendoza (Argentina)","resumen":"El objetivo de este trabajo es analizar la red social virtual (en este caso Facebook) de adolescentes que asisten a un colegio rururbano marginal de Mendoza (Argentina), y estudiar las percepciones que ellos manifiestan sobre los tipos de apoyo que les brinda. Se tomó a un curso del último año de una escuela secundaria compuesto por 23 alumnos de una edad promedio de 17 años (el 67% eran mujeres). En su mayoría provienen de familias cuyos padres no poseen ingresos estables.La metodología utilizada es la propia del análisis de redes sociales (realización de grafos con el software TouchGraph, análisis de centralidad, subgrupos y nodos de la red), aplicación de métodos estadísticos y metodología cualitativa (entrevistas individuales y Focus group).Con respecto al estudio de las redes personales a través del uso de Facebook, se apreció una masividad en el uso de esta red (sólo dos casos no lo utilizan), no existiendo diferencias significativas según el género, en el número de amigos. Finalmente desde la percepción de los estudiantes, Facebook sirve para reforzar el apoyo informacional, tangible y afectivo, pero no tanto el apoyo axiológico.","palabras_clave":"REDES PERSONALES|FUENTES DE APOYO|MEDIO RURURBANO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18937,"idioma_id":5,"titulo":"INFLUENCIA AMBIENTAL SOBRE MOVIMIENTO Y COMPORTAMIENTO DE VACAS EN PASTOREO EXTENSIVO","resumen":"El movimiento animal en pastoreo extensivo, se relaciona, entre otras cosas, con el grado de utilización de la vegetación existente. En diversas situaciones se observa que la distancia recorrida diariamente presenta importantes variaciones y en distintos días las vacas no se aproximan a la bebida, por lo tanto no consumen agua.   Se plantea el interrogante la influencia de las condiciones ambientales sobre éste comportamiento, sobre todo en pastoreos estivales donde el consumo de agua resulta imprescindible para enfrentar las elevadas temperaturas de ambientes semiáridos y poder satisfacer la demanda fisiológica de vacas que se encuentran finalizando su gestación o en periodo de lactancia, sobre recursos forrajeros nativos.  El 29% de los días registrados, los vientres monitoreados no se aproximaron a la bebida y por lo tanto no consumieron agua; de modo individual presentan variaciones entre 19 y 36% sobre el total de los días. La distancia caminada por los animales cuando no accedieron al agua de bebida fue significativamente menor, en un 30.4% (p<0.0001; Cuadro 1).  No se detectan diferencias estadísticas entre animales, siendo la distancia media recorrida diariamente por las vacas monitoreadas de 5827,7 m (EE: 96,6), alcanzando valores máximos superiores a 10000 m.   Las condiciones meteorológicas predominantes de los días en que los animales no consumieron agua fueron una menor temperatura, con disminución en la intensidad de radiación solar. También se registraron pero de modo eventual, precipitaciones, aumentos de la humedad atmosférica, o vientos persistentes a lo largo del día. Las vacas consideradas permanecieron entre 2 y 5 días consecutivos sin acercarse a la bebida, siendo el factor coincidente para todos los casos la disminución de temperaturas y de radiación solar incidente. Se registran distintos eventos meteorológicos, pero en los días señalados ocurre la conjunción de factores, que podrían estar condicionando el comportamiento animal en pastoreo. Dado el estado fisiológico de los vientres monitoreados, en algún momento puede haber ocurrido la parición, pero no fue posible identificarla.  del presente trabajo se puede concluir que los vientres de cría bovinos en pastoreo extensivo no consumen agua de manera diaria, y pueden permanecer varios días sin acceder al agua de bebida, aún en estaciones críticas tanto por las condiciones climáticas como por su estado fisiológico.   De acuerdo al análisis realizado, las condiciones meteorológicas estivales que permiten que las vacas en pastoreo extensivo no consuman agua y eviten trasladarse hasta la bebida, son el efecto combinado de una disminución de temperatura asociada a incrementos de la nubosidad (disminución de la radiación solar). Bajo esas características, la distancia caminada diariamente es menor.","palabras_clave":"COMPORTAMIENTO ANIMAL|INFLUENCIA CLIMATICA|EFECTO AMBIENTAL|MONITOREO GPS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18938,"idioma_id":5,"titulo":"EFECTO DE LA HELADA TEMPRANA EN PLANTAS DE SORGO PARA SILAJE","resumen":"En la región semiárida, el cultivo de sorgo resulta una alternativa forrajera más segura que el de maíz debido a su mayor tolerancia al estrés hídrico, situación frecuente en dicho ambiente. La siembra de sorgo se planifica para generar forraje en pie o como reserva. Cuando se lo utiliza como silaje, la planta, puede verse afectada por heladas tempranas que superan la crítica letal (-2,-3°C, según (Snyder y de Melo-Abreu, 2005) antes de ser picada y ensilada. Posteriormente deviene la senescencia, aumento de MS  y disminución de la calidad del forraje a ensilar (Gallardo, 2013). Ante ésta situación, se planteó evaluar el efecto poshelada en plantas de sorgo ulteriormente microensiladas, sobre características organolépticas, pH, temperatura y MS.  Resultados y discusión  Todos los tratamientos (testigo y helados) presentaron características sensoriales, pH y MS acordes a un buen silaje. La temperatura (20 °C) se mantuvo próxima a la ambiental. En el análisis multivariado se consideraron las variables aroma, color, MS, pH y textura. Se diferenciaron dos grupos (Figura 1), uno correspondiente al Testigo (GT) y otro conformado por los 5 tratamientos realizados con material helado (GH). No hubo diferencias en aroma, color y textura entre grupos. Las diferencias estuvieron dadas, principalmente, por la MS (GT: 33 %; GH: 38 %). Entre MS y días desde helada se describió un modelo de ajuste lineal con buen coeficiente de correlación (MS: 34,84 + 0,37.días, r= 0,65). La MS y pH (GT: 4,5 y GH: 4,2) de los microsilos siempre estuvieron dentro del rango recomendado para un buen silaje (MS: 32-42 % y pH: <4,5), resultados que concuerdan con lo indicado por Piñeiro (2010) y Gallardo (2013).   Conclusión  Bajo las condiciones planteadas, es factible esperar hasta 12 días posteriores a la ocurrencia de la primera helada para cortar, picar y ensilar un cultivo de sorgo, sin que se manifiesten alteraciones importantes de MS, pH y características organolépticas.","palabras_clave":"HELADAS|SILO DE SORGO|MICROSILOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18939,"idioma_id":4,"titulo":"Signature of consciousness in the dynamics of resting-state brain activity","resumen":"At rest, the brain is traversed by spontaneous functional connectivity patterns. Two hypotheses have been proposed for their origins: they may reflect a continuous stream of ongoing cognitive processes as well as random fluctuations shaped by a fixed anatomical connectivity matrix. Here we show that both sources contribute to the shaping of resting-state networks, yet with distinct contributions during consciousness and anesthesia. We measured dynamical functional connectivity with functional MRI during the resting state in awake and anesthetized monkeys. Under anesthesia, the more frequent functional connectivity patterns inherit the structure of anatomical connectivity, exhibit fewer small-world properties, and lack negative correlations. Conversely, wakefulness is characterized by the sequential exploration of a richer repertoire of functional configurations, often dissimilar to anatomical structure, and comprising positive and negative correlations among brain regions. These results reconcile theories of consciousness with observations of long-range correlation in the anesthetized brain and show that a rich functional dynamics might constitute a signature of consciousness, with potential clinical implications for the detection of awareness in anesthesia and brain-lesioned patients.","palabras_clave":"consciousness|functional connectivity|structural connectivity|dynamics|anesthesia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18940,"idioma_id":5,"titulo":"Incidencias de la Ley Nacional de Salud Mental en los dispositivos de guardia desde la perspectiva de los profesionales psicólogos y psiquiatras","resumen":"En el siguiente artículo nos proponemos indagar sobre la incidencia de la Ley Nacional de Salud Mental N° 26.657, en los dispositivos de guardia de distintos hospitales de la Ciudad Autónoma de Buenos Aires y Provincia de Buenos Aires. Tomaremos como referencia para ello  los resultados obtenidos en la investigación UBACyT 2012-2015 ?Los dispositivos para alojar la urgencia en Salud Mental, desde la  mirada de los profesionales, psiquiatras y psicólogos, que intervienen en ellos?.  Para el análisis de los mismos seleccionaremos, en cada uno de los protocolos que integran la muestra, las respuestas relacionadas con el tema en cuestión.","palabras_clave":"SALUD|MENTAL|DERECHO|GUARDIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18941,"idioma_id":4,"titulo":"Method to Reduce Complexity and Response Time in a Web Search","resumen":"Living in times of technological changes that alter our daily activities, involving tasks such as reading the newspaper, following the weather, scheduling a trip, are usually executed after perusal of the gigantic repository of information, commonly known as the World Wide Web. However some problems are still associated with the information found in such a vast amount of information: heterogeneity, availability, distribution, quality and quantity of irrelevant information. Recent work has suggested different ways of grouping similar information sources, trying to give solutions to these problems. However, some domains are more complex than others. For example, a person looking for tourist information, is generally overwhelmed by visiting various websites. This paper proposes the implementation of a method to retrieve and group web information sources, depending on the services they offer; thereby allowing the user to get accurate answers; thus reducing the time and complexity in the search.","palabras_clave":"Information Retrieval|Internet|Tourism|Web Information Sources"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18942,"idioma_id":4,"titulo":"A protocol for the micropropagation and in vitro polyploidization of an interspecific hybrid of Glandularia (G. peruviana x G. scrobiculata)","resumen":"tThe genus Glandularia (Verbenaceae) has more than 50 species and it holds great ornamental poten-tial due to its colorful flowers, long flowering period and low water requirements. Since the floriculturemarket avidly seeks novelties, increasing the diversity within the genus would increase its commercialvalue. Some of the traits that should be improved in these species are their architecture and the sizeand colors of the flowers and leaves. In this sense, obtaining polyploid individuals is an interesting strat-egy to achieve this objective. In this paper a hybrid of Glandularia peruviana × Glandularia scrobiculatawas cultured under in vitro conditions. Different plant growth regulators and their combinations weretested to obtain appropriate multiplication rates. The best results were obtained with the combination of6.6 M thidiazuron\/0.03 M -naphthalenacetic acid, with a multiplication rate of 19 shoots per explant.The plantlets were first rooted and then acclimatized by transferal to an 8.0 cm diameter pot containingGrowing mix®, and maintenance inside a humidity chamber. For poliploydization, the explants wereexposed to colchicine in concentrations of 0.001% and 0.01% for 24 and 48 h. The 40 recovered plantswere characterized according to their DNA content. There were 21 diploids, 14 solid tetraploids, 1 solidoctoploid, 3 chimera tetraploids and 1 chimera octoploid. Phenotypically, the size of the flowers, inflo-rescences, pollen grains and stomata were significantly larger in polyploid individuals. Surprisingly, stemdiameter, leaf size and color intensity of the leaves and flowers were not significantly different betweendiploid and tetraploid individuals. Due to the size of the inflorescences, the tetraploid individuals are apromising starting material for a Glandularia breeding program.","palabras_clave":"Plant Biotechnology|tissue culture|ornamental plants|breeding"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18943,"idioma_id":4,"titulo":"Immunization with Brucella VirB Proteins Reduces Organ Colonization in Mice through a Th1-Type Immune Response and Elicits a Similar Immune Response in Dogs","resumen":"    VirB proteins from Brucella spp. constitute the Type IV secretion  system, a key virulence factor mediating the intracellular survival of these  bacteria. Here we assessed whether a  Th1-type immune response against VirB proteins may protect mice from Brucella infection, and whether such  response can be induced in the dog, a natural host for Brucella. Splenocytes from mice immunized with VirB7 or  VirB9 responded to their respective antigens with a significant and specific  production of IFN-&#947;, whereas IL-4 was not detected. Thirty days after  intraperitoneal challenge with live B.  abortus the spleen load of bacteria was almost one log lower in mice  immunized with VirB proteins than in unvaccinated animals. As colonization  reduction seemed to correlate with a Th1-type immune response against VirB  proteins, we decided to assess whether such response could be elicited in the  dog. PBMCs from dogs immunized with VirB proteins (three subcutaneous doses in  QuilA adjuvant) produced significantly higher leves of IFN-&#947; than cells from  control animals upon in vitro  stimulation with VirB proteins. A skin test to assess specific delayed-type  hypersensitivity was positive in 4 out of 5 dogs immunized with either VirB7 or  VirB9. As both proteins are predicted to locate in the outer membrane of Brucella, the ability of anti-VirB  antibodies to mediate complement-dependent bacteriolysis of B. canis was assessed in vitro. Sera from dogs immunized with  either VirB7 or VirB9, but not from those receiving PBS, produced a significant  bacteriolysis. These results suggest that VirB-specific responses that reduce organ  colonization by B. canis in mice can  be also elicited in dogs.","palabras_clave":"INMUNIZACION|BRUCELLA|RATON|PERRO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18944,"idioma_id":5,"titulo":"La regulación del contrato de comodato en el Código Civil y Comercial","resumen":"Luego del recorrido efectuado por el conjunto de disposiciones del nuevo Código Civil y Comercial de la Nación que delimitan el tipo legal del comodato, es posible concluir que la modernización  que ellas entrañan  no resulta sólo del empleo de una técnica legislativa cuidada y prolija,  ni de la simplificación  del régimen normativo, sino que las transformaciones más profundas  resultan, en última instancia, consecuencia del sentido general de la recodificación. Al respecto, parece que las consecuencias emergentes de la unificación del régimen legal de obligaciones y contratos civiles y comerciales  que caracteriza a la metodología del Código, como así también el régimen específico que se adopta para los contratos de consumo, impactan de manera significativa en  funcionamiento del  comodato en el marco de la contratación contemporánea.","palabras_clave":"CONTRATO|COMODATO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18945,"idioma_id":4,"titulo":"Chemical Stability toward O 2 and H 2 O of Si(111) Grafted with - CH 3 , - CH 2 CH 2 CH 3 , - CHCHCH 3 , and - CCCH 3","resumen":"The chemical stability of compact monolayers on silicon toward oxidizing agents is a key issue for the use of such monolayers in devices such as solar cells or in the electronics industry. In this work, we investigated the reactivity toward H2O, O2, and OH species of monolayers terminated with a methyl group to unveil the mechanisms that prevent the oxidation of the underlying silicon. Density functional theory calculations were performed to investigate the reaction pathways for the two competing processes involved: diffusion through the monolayer and reaction with the terminal methyl group. Activation energy barriers for the diffusion of H2O and O2 are very sensitive to the monolayer structure, and they increase in the order ?CH2?CH2?CH3 &lt; ?C&#8801;C?CH3 &lt; ?CH&#9552;CH?CH3 with energy barriers of 0.0 kcal\/mol (0.0 kcal\/mol), 35.0 kcal\/mol (42.5 kcal\/mol), and 57.0 kcal\/mol (64.1 kcal\/mol), respectively, for H2O (O2). This agrees with ordering of stabilities reported experimentally for these monolayers. The oxidation of the terminal methyl group by O2 is less affected by steric constraints. The formation of the ?CH2OOH species has an energy barrier of 56.5 kcal\/mol on the rigid ?CH3 monolayer, whereas this barrier decreases to 40.7 kcal\/mol on the ?C&#8801;C?CH3 monolayer. In the case of the methyl monolayer, the abstraction of a H atom of the ?CH3 group has smaller energy barriers with singlet O2 and OH reactants, with values of 38.4 and 3.5 kcal\/mol, respectively. The high energy barriers of all of the processes investigated indicate that compact monolayers hinder the oxidation of the underlying substrate. The passivating capability of the monolayers correlates with the steric constraints for H2O and O2 diffusion.","palabras_clave":"silicon surfaces|stability|oxidation|DFT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18946,"idioma_id":5,"titulo":"EVALUACIÓN COMPARATIVA DE DOS MÉTODOS DE VALIDACIÓN PARA INTERPOLACIÓN DE ONDULACIONES DE LA SUPERFICIE GEOIDAL","resumen":"El empleo de modelos de ondulaciones geoidales se ha generalizado a  partir del advenimiento del  posicionamiento satelital. Estos modelos son generados mediante procedimientos  de interpolación entre valores de ondulación medida, dentro de la zona que se  pretende modelar. La calidad del modelo obtenido depende, entre otros factores,  de la calidad de la interpolación. Para conocer la calidad del modelo estos son  sometidos a procesos de validación que en general contrastan los valores  predichos por el modelo con el valor medido en determinados puntos de  control. Este trabajo presenta la  comparación entre dos de los métodos más utilizados para la validación de  procesos de interpolación. Trabajando con una totalidad de 50 puntos se  generaron modelos de ondulaciones geoidales con 7 diferentes métodos de  interpolación. Los modelos resultantes fueron sometidos a dos procesos de  validación, utilizando la validación cruzada dejando uno fuera y el método de  tabla de aprendizaje y tabla de prueba. Del análisis comparativo de los  resultados que arrojaron las validaciones de los modelos generados con los  diferentes métodos, surge claramente que con la validación cruzada dejando uno  fuera, se obtienen mejores resultados que cuando se emplea el enfoque tabla de  aprendizaje y tabla de prueba.","palabras_clave":"EVALUACION|VALIDACION|INTERPOLACION|GEOIDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18947,"idioma_id":4,"titulo":"Re-storying violence and its aftermath through film","resumen":"For many years, psychologists and psychoanalysts have ?interpreted? films, including the private lives of directors, believing that they would thereby discover the key to these works of art.  In this review, two psychologists ask the opposite question: What can film teach those who work in health and mental health? And, more particularly, what do these films teach us about violence in Guatemala.  We suggest here that the contrasting aesthetics of the filmmakers helps us appreciate two complementary faces of violence: On the one hand, that of beauty subjugated by ?progress? (the angel of History) - beauty rescued in the film through the recovery of singular stories. On the other hand, the realistic, even crude reality of violence visualized through damaged bodies, treated as garbage. Yet the camera is a rudiment of mediation, revealing words ? a confession ? of an executioner. Film becomes, thus, an intervention strategy as much for those who make it, the protagonists, as for those who submerge themselves in the horror through the light emerging on a screen in a darkened theater.","palabras_clave":"CINE|ETICA|VIOLENCIA|NARRATIVAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18948,"idioma_id":4,"titulo":"Amaranth protein films reinforced with maize starch nanocrystals","resumen":"The effect of the addition of starch nanocrystals e prepared from waxy and normal maize starch granules e to amaranth protein formulations on the physicochemical and structural properties of the resulting nanocomposite films was studied. All nanocomposites films were homogeneous, translucent and had similar thickness and optical properties than the neat protein film due to the good dispersion of the nanoreinforcements in the protein matrix and the good chemical affinity between both components. Nevertheless, the presence of nanocrystals affected differently the way in which protein matrix  stabilized,according to the origin of the reinforcement: mainly by disulfide bonds for waxy maize nanocrystals and by hydrogen bonds for normal maize nanocrystals. This induced a different reinforcing effect for amaranth protein films, being more significant for normal maize nanocrystals that however presented a lower crystallinity. Moreover, nanocomposite films presented improved water vapor permeability (WVP), water uptake (WU), surface hydrophobicity and mechanical behavior than proteins filmsand also a delay in their weight loss in soil.","palabras_clave":"Bionanocomposites|biodegradable films|starch nanocrystals|botanical origen| amaranth proteins"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18949,"idioma_id":5,"titulo":"Cambios académicos e institucionales en la escuela secundaria bonaerense durante el primer ciclo de reformas","resumen":"Entre los años 1993 y 2006, en Argentina se aprobaron dos leyes orgánicas de educación. Ellas reformaron el sistema educativo en distintos sentidos, no congruentes entre sí: modificaron la estructura académica, introdujeron cambios institucionales, curriculares y administrativos. Si algo tuvieron en común estas reformas fue la ausencia de una planificación integral y la ejecución diferencial en las distintas jurisdicciones del país. La primera de ellas, la Ley Federal de Educación (1993), se enmarcó en una serie de políticas de descentralización del sistema educativo que dieron lugar a formas de organización institucional diferentes a las vigentes hasta entonces. Es su aplicación en la Provincia de Buenos Aires la que guía el presente trabajo, analizando las reformas en el plano administrativo, institucional y académico del nivel secundario entre los años 1994 y 2005 así como los problemas que se derivaron.","palabras_clave":"REFORMA EDUCATIVA|CAMBIOS CURRICULARES|ESTRUCTURA ACADÉMICA|PROVINCIA DE BUENOS AIRES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18950,"idioma_id":4,"titulo":"Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity.","resumen":"We explored the role of transmembrane 6 superfamily member 2 (TM6SF2)rs58542926 C\/T nonsynonymous (p.Glu167Lys) variant in genetic susceptibility to nonalcoholicfatty liver disease (NAFLD) and disease severity. A total of 361 individuals(135 control subjects and 226 patients with histologically proven NAFLD) wereincluded in a sample with 97% power for the additive genetic model. A discrete traitanalysis of NAFLD showed that rs58542926 was associated with a modest risk of fattyliver (P50.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless,conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect. We did not observe an interaction between rs738409 andrs58542926 variants on the risk of NAFLD. We observed a significant association ofrs58542926 and disease severity (P50.027), but not lobular inflammation or fibrosis;rs58542926 was not associated with levels of liver enzymes. An allelic test showed thatthe T (Lys167) allele was significantly associated with disease progression (P50.021;OR, 1.66; 95% CI: 1.08-2.55). A significant association was found with the histologicaldegree of liver steatosis (b, 0.15; standard error: 0.06; P50.0299) that was independentof rs738409. Homozygous carriers of the C (Glu167) allele showed increased risk forcardiovascular disease. TM6SF2 protein expression was decreased markedly in liver ofNAFLD patients, compared to controls. In addition, TM6SF2 immunoreactivity wasreduced in subjects carrying at least one copy of the T allele, consistent with a differencein liver allele-specific transcript abundance. Conclusion: rs58542926 is a low-frequencyvariant with a modest effect on NAFLD, suggesting that carriers of the T allele areslightly more likely to accumulate fat in the liver and develop nonalcoholic steatohepatitisthan those without. TM6SF2 appears to play a significant role in disease biology.TM6SF2)rs58542926 C\/T nonsynonymous (p.Glu167Lys) variant in genetic susceptibility to nonalcoholicfatty liver disease (NAFLD) and disease severity. A total of 361 individuals(135 control subjects and 226 patients with histologically proven NAFLD) wereincluded in a sample with 97% power for the additive genetic model. A discrete traitanalysis of NAFLD showed that rs58542926 was associated with a modest risk of fattyliver (P50.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless,conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect. We did not observe an interaction between rs738409 andrs58542926 variants on the risk of NAFLD. We observed a significant association ofrs58542926 and disease severity (P50.027), but not lobular inflammation or fibrosis;rs58542926 was not associated with levels of liver enzymes. An allelic test showed thatthe T (Lys167) allele was significantly associated with disease progression (P50.021;OR, 1.66; 95% CI: 1.08-2.55). A significant association was found with the histologicaldegree of liver steatosis (b, 0.15; standard error: 0.06; P50.0299) that was independentof rs738409. Homozygous carriers of the C (Glu167) allele showed increased risk forcardiovascular disease. TM6SF2 protein expression was decreased markedly in liver ofNAFLD patients, compared to controls. In addition, TM6SF2 immunoreactivity wasreduced in subjects carrying at least one copy of the T allele, consistent with a differencein liver allele-specific transcript abundance. Conclusion: rs58542926 is a low-frequencyvariant with a modest effect on NAFLD, suggesting that carriers of the T allele areslightly more likely to accumulate fat in the liver and develop nonalcoholic steatohepatitisthan those without. TM6SF2 appears to play a significant role in disease biology.P50.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless,conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect. We did not observe an interaction between rs738409 andrs58542926 variants on the risk of NAFLD. We observed a significant association ofrs58542926 and disease severity (P50.027), but not lobular inflammation or fibrosis;rs58542926 was not associated with levels of liver enzymes. An allelic test showed thatthe T (Lys167) allele was significantly associated with disease progression (P50.021;OR, 1.66; 95% CI: 1.08-2.55). A significant association was found with the histologicaldegree of liver steatosis (b, 0.15; standard error: 0.06; P50.0299) that was independentof rs738409. Homozygous carriers of the C (Glu167) allele showed increased risk forcardiovascular disease. TM6SF2 protein expression was decreased markedly in liver ofNAFLD patients, compared to controls. In addition, TM6SF2 immunoreactivity wasreduced in subjects carrying at least one copy of the T allele, consistent with a differencein liver allele-specific transcript abundance. Conclusion: rs58542926 is a low-frequencyvariant with a modest effect on NAFLD, suggesting that carriers of the T allele areslightly more likely to accumulate fat in the liver and develop nonalcoholic steatohepatitisthan those without. TM6SF2 appears to play a significant role in disease biology.PNPLA3)-rs738409 abolished this effect. We did not observe an interaction between rs738409 andrs58542926 variants on the risk of NAFLD. We observed a significant association ofrs58542926 and disease severity (P50.027), but not lobular inflammation or fibrosis;rs58542926 was not associated with levels of liver enzymes. An allelic test showed thatthe T (Lys167) allele was significantly associated with disease progression (P50.021;OR, 1.66; 95% CI: 1.08-2.55). A significant association was found with the histologicaldegree of liver steatosis (b, 0.15; standard error: 0.06; P50.0299) that was independentof rs738409. Homozygous carriers of the C (Glu167) allele showed increased risk forcardiovascular disease. TM6SF2 protein expression was decreased markedly in liver ofNAFLD patients, compared to controls. In addition, TM6SF2 immunoreactivity wasreduced in subjects carrying at least one copy of the T allele, consistent with a differencein liver allele-specific transcript abundance. Conclusion: rs58542926 is a low-frequencyvariant with a modest effect on NAFLD, suggesting that carriers of the T allele areslightly more likely to accumulate fat in the liver and develop nonalcoholic steatohepatitisthan those without. TM6SF2 appears to play a significant role in disease biology.P50.027), but not lobular inflammation or fibrosis;rs58542926 was not associated with levels of liver enzymes. An allelic test showed thatthe T (Lys167) allele was significantly associated with disease progression (P50.021;OR, 1.66; 95% CI: 1.08-2.55). A significant association was found with the histologicaldegree of liver steatosis (b, 0.15; standard error: 0.06; P50.0299) that was independentof rs738409. Homozygous carriers of the C (Glu167) allele showed increased risk forcardiovascular disease. TM6SF2 protein expression was decreased markedly in liver ofNAFLD patients, compared to controls. In addition, TM6SF2 immunoreactivity wasreduced in subjects carrying at least one copy of the T allele, consistent with a differencein liver allele-specific transcript abundance. Conclusion: rs58542926 is a low-frequencyvariant with a modest effect on NAFLD, suggesting that carriers of the T allele areslightly more likely to accumulate fat in the liver and develop nonalcoholic steatohepatitisthan those without. TM6SF2 appears to play a significant role in disease biology.P50.021;OR, 1.66; 95% CI: 1.08-2.55). A significant association was found with the histologicaldegree of liver steatosis (b, 0.15; standard error: 0.06; P50.0299) that was independentof rs738409. Homozygous carriers of the C (Glu167) allele showed increased risk forcardiovascular disease. TM6SF2 protein expression was decreased markedly in liver ofNAFLD patients, compared to controls. In addition, TM6SF2 immunoreactivity wasreduced in subjects carrying at least one copy of the T allele, consistent with a differencein liver allele-specific transcript abundance. Conclusion: rs58542926 is a low-frequencyvariant with a modest effect on NAFLD, suggesting that carriers of the T allele areslightly more likely to accumulate fat in the liver and develop nonalcoholic steatohepatitisthan those without. TM6SF2 appears to play a significant role in disease biology.b, 0.15; standard error: 0.06; P50.0299) that was independentof rs738409. Homozygous carriers of the C (Glu167) allele showed increased risk forcardiovascular disease. TM6SF2 protein expression was decreased markedly in liver ofNAFLD patients, compared to controls. In addition, TM6SF2 immunoreactivity wasreduced in subjects carrying at least one copy of the T allele, consistent with a differencein liver allele-specific transcript abundance. Conclusion: rs58542926 is a low-frequencyvariant with a modest effect on NAFLD, suggesting that carriers of the T allele areslightly more likely to accumulate fat in the liver and develop nonalcoholic steatohepatitisthan those without. TM6SF2 appears to play a significant role in disease biology.Conclusion: rs58542926 is a low-frequencyvariant with a modest effect on NAFLD, suggesting that carriers of the T allele areslightly more likely to accumulate fat in the liver and develop nonalcoholic steatohepatitisthan those without. TM6SF2 appears to play a significant role in disease biology.","palabras_clave":"TM6SF2|NAFLD|NASH|FIBROSIS|GENETICS|LIVER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18951,"idioma_id":4,"titulo":"Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis","resumen":"&nbsp;        Objectives:  We used a screening strategy of global  serum miRNA profiling, followed by a second stage of  independent replication and exploration of liver expression of selected miRNAs  to study: (1) the circulating miRNA  signature associated with nonalcoholic fatty liver disease (NAFLD) progression  and predictive power, (2) the role of miRNAs in disease biology, and (3) the association between circulating miRNAs  and features of the metabolic syndrome.         Methods: The  study used a case-control design and included patients with NAFLD proven through biopsy and healthy controls.         Results: Among 84 circulating miRNAs analyzed,  miR-122, miR-192, miR-19a and 19b, miR-125b, and miR-375 were up-regulated  &gt;2-fold (p&lt;0.05) either in simple steatosis (SS) or nonalcoholic steatohepatitis (NASH). The most  dramatic and significant fold changes were observed in the serum levels of miR-122 (7.2-fold  change in NASH versus controls and  3.1-fold change in NASH versus SS) and miR-192 (4.4-fold change in NASH versus  controls); these results were replicated in the validation set. The majority of serum miR-122 circulates in argonaute2-free  forms. Circulating miR-19a\/b and miR-125b were correlated with biomarkers of  atherosclerosis. Liver miR-122 expression was 10-fold (p&lt;0.03) down-regulated in NASH compared with  SS and was preferentially expressed at  the edge of lipid-laden hepatocytes. In vitro exploration showed that overexpression of miR-122  enhances alanine aminotransferase activity.         Conclusion: miR-122 plays a role of  physiological significance in the biology of NAFLD; circulating miRNAs mirror  the histologic and molecular events occurring in the liver. NAFLD has a  distinguishing circulating miRNA profile associated with a global dysmetabolic  disease state and cardiovascular risk.","palabras_clave":"MIRNAS|NAFLD|DISEASE SEVERITY|BIOMARKERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18952,"idioma_id":4,"titulo":"Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension","resumen":"We tested the hypothesis that leukocyte telomere length (LTL) is   associated with birth weight in both extremes of abnormal fetal growth:   small (SGA) and large for gestational age newborns (LGA). Clinical and   laboratory variables of the mothers and the neonates were explored; 45   newborns with appropriate weight for gestational age (AGA), 12 SGA and   12 LGA were included. Whether the differences might be explained by   variation in OBFC1 (rs9419958) and CTC1 (rs3027234) genes associated   with LTL was determined. A significant association between birth weight   and LTL was observed; LTL was significantly shorter in LGA newborns   (1.01 ± 0.12) compared with SGA (1.73 ± 0.19) p &lt; 0.005, mean ± SE.   Maternal (Spearman R = -0.6, p = 0.03) and neonatal LTL (R = -0.25, p =   0.03) were significantly and inversely correlated with maternal history   of arterial hypertension in previous gestations. Neonatal LTL was not   significantly associated with either rs9419950 or rs3027234, suggesting   that the association between neonatal LTL and birth weight is not   influenced by genetic variation in genes that modify the interindividual   LTL. In conclusion, telomere biology seems to be modulated by abnormal   fetal growth; modifications in telomere length might be programmed by an   adverse environment in utero.","palabras_clave":"METABOLIC SYNDROME|TELOMERE LENGHT|FETAL PROGRAMMING|OBESITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18953,"idioma_id":4,"titulo":"Structure-from-Motion Approach for Characterization of Bioerosion Patterns Using UAV Imagery","resumen":"The aim of this work is to evaluate the applicability of the 3D model obtained through Structure-from-Motion (SFM) from unmanned aerial vehicle (UAV) imagery, in order to characterize bioerosion patterns (i.e., cavities for roosting and nesting) caused by burrowing parrots on a cliff in Bahía Blanca, Argentina. The combined use of SFM-UAV technology was successfully applied for the 3D point cloud model reconstruction. The local point density, obtained by means of a sphere of radius equal to 0.5 m, reached a mean value of 9749, allowing to build a high-resolution model (0.013 m) for resolving fine spatial details in topography. To test the model, we compared it with another point cloud dataset which was created using a low cost do-it-yourself terrestrial laser scanner; the results showed that our georeferenced model had a good accuracy. In addition, an innovative method for the detection of the bioerosion features was implemented, through the processing of data provided by SFM like color and spatial coordinates (particularly the y coordinate). From the 3D model, we also derived topographic calculations such as slope angle and surface roughness, to get associations between the surface topography and bioerosion features.","palabras_clave":"Structure-from-Motion Approach| unmanned aerial vehicle|3D point cloud;|topography"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18954,"idioma_id":4,"titulo":"PNPLA3 I148M variant is associated with metabolic stress-response phenotype in patients with nonalcoholic fatty liver disease","resumen":"In this case series, we report a novel observation in patients with nonalcoholic fatty liver disease and show a significant association between the PNPLA3 rs738409 (I148M) variant and the lactate-to-pyruvate ratio, confirming the complex liver metabolic regulatory pathway in which PNPLA3 is involved.","palabras_clave":"PNPLA3|LACTATE|PYRUVATE|GENETICS|I148M|METABOLOMICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18955,"idioma_id":4,"titulo":"Atypical Cystic Echinococcosis in a young child","resumen":"An almost 4-year-old Argentinian girl had abdominal pain and daily fevers of 38.5°C for 5 days. She appeared to be in good general condition except for petechiallesions on the anterior trunk. She also had a painful and tense abdomen on light palpation. Abdominal ultrasonography revealed a large intraperitoneal cystic lesion measuring 11.56 cm × 10.5 cm × 4.18 cm with thin walls and liquid in the cavity (See Figure, Supplemental Digital Content 1, http:\/\/ links.lww.com\/INF\/B990). Laboratory tests showed slight eosinophilia. Preoperative diagnosis was a congenital cystic mass of the mesenterium. Laparotomy showed liquid in the cavity and a flaccid cyst of very thin walls surrounded by the small intestine, the stomach and the omentum. During removal, it was damaged and it resembled a hydatid membrane. The abdominal cavity was washed with physiologic solution and hypertonic saline solution-soaked pads were used. The patient had an uneventful recovery and received albendazole treatment (15 mg\/kg\/day). She was discharged after the third postoperative day when abdominal ultrasonography and chest radiography were normal. Outpatient follow-up included abdominal ultrasonography bimonthly and albendazole treatment. Histopathological examination confirmed hydatid cyst showing laminated and germinal layers with abundant eosinophils, multinucleated giant cells and scoleces (See Figure, Supplemental Digital Content 2, http:\/\/links.lww.com\/ INF\/B991, which shows a histophatological section of hydatic cyst. Laminal layer, germinal layer and vesicle with 2 scoleces are seen. HE stain).Intraperitoneal hydatid cysts usuallydevelop secondary to spontaneous or iatrogenic rupture of hepatic, splenic or mesenteric cysts. Rarely, an isolated primary cyst can develop in the peritoneum without evidence of cysts in other intra-abdominal organs.1 The growth rate of a hydatid cyst has been variably reported at 1?16 cm per year in abdomen.2 Abdominal cystic echinococcosis had been infrequently reported and only in adults.3 If the girl ingested the oncosphere in the first semester of life, an estimated minimum growth rate of the cyst was 2.5?3 cm per year. Canine coproparasitological researchin the environment where the family was living showed a dog with Taenia spp. Thesefindings confirm the persistence of the habit of feeding dogs with raw offal and theexistence of hosts involved in the parasite life cycle, which represent risk factors to develop cystic echinococcosis or other parasitic diseases.","palabras_clave":"INTRAPERITONEAL HYDATID CYST |SURGERY|CANINE ZOONOTIC PARASITES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18956,"idioma_id":4,"titulo":"Metal coordination study at Ag and Cd sites in Crown Thioether complexes through DFT calculations and hyperfine parameters","resumen":"Structural and electronic properties of  [C12H24S6X], [C13H26S6OX], and [C14H28S6OX] (X: Ag+  ,  Cd2+) crown thioether complexes were investigated within  the framework of the density functional theory (DFT) using  the projector augmented wave (PAW) method. The theoretical  results were compared with time-differential perturbed &#947;?&#947;  angular correlations (TDPAC) experiments reported in the literature  using the 111Ag&#8594;111Cd probe. In the case of X=Ag+  , a  refinement of the structure was performed and the predicted  equilibrium structures compared with available X-ray diffraction  experimental data. Structural distortions induced by replacing  Ag+ with Cd2+ were investigated as well as the  electric-field gradient (EFG) tensor at the Cd2+ sites. Our results  suggest that the EFG at Cd2+ sites corresponds to the Ag+  coordination sphere structure, i.e., before the structural relaxations  of the molecule with X=Cd2+ are completed. The results  are discussed in terms of the characteristics of the  TDPAC 111Ag&#8594;111Cd probe and the time window of the  measurement, and provide an interesting tool with which to  probe molecular relaxations.","palabras_clave":"ab initio|hyperfine parameters|crown thioether|Metal coordination"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18957,"idioma_id":4,"titulo":"Population Pharmacokinetic Study of Vancomycin in Preterm Neonates","resumen":"The aim was to characterize the population pharmacokinetics of vancomycin in preterm neonates and identify related covariates. 140 preterm neonates received a 1-h infusion of vancomycin at Hospital JP Garrahan between 2008-2012 and were subjected to therapeutic monitoring. Pharmacokinetic data was analyzed by means of nonlinear mixed-effects modeling. A total of 31 demographic and patientcharacteristics were analyzed as covariates. A one-compartment model with combined residual error was fit to vancomycin concentrations. Large between-subject variability was observed in elimination rate constant (ke, 64%) and volume of distribution (V, 58%). The covariate analysis indicated that the most significant covariates were body weight and serum creatinine, explaining in total 16% and 40% of the betweensubject variability for vancomycin ke and V, respectively. We developed a population pharmacokinetic model identifying patient covariates related to vancomycin disposition in preterm neonates. The model may be translated into the clinics to aid individualizing vancomycin dosing.","palabras_clave":"VANCOMICINA|MODELO POBLACIONAL|NEONATOS|PRETERMINO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18958,"idioma_id":5,"titulo":"Acerca del criterio de optimización basado en la maximización de la utilidad esperada","resumen":"En este trabajo se analizan la validez y los alcances de la definición de esperanza matemática y las condiciones formales que debe satisfacer la función de utilidad a fin de garantizar la validez del criterio de optimización basado en la maximización de la utilidad esperada. En particular, se realiza un análisis crítico de las justificaciones de la aparente preferencia por la violación del axioma de independencia de Von Neumman?Morgenstern y una corrección a los postulados del teorema de Menger a partir de las funciones de preferencias suavizadas.","palabras_clave":"UTILIDAD ESPERADA|PROBABILIDAD |PARADOJA DE SAN PETESBURGO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18959,"idioma_id":4,"titulo":"Thermosensing via transmembrane protein-lipid interactions","resumen":"Cell membranes are composed of a lipid bilayer containing proteins that cross and\/or interact with lipids oneither side of the two leaflets. The basic structure of cell membranes is this bilayer, composed of two opposinglipidmonolayerswith fascinating properties designed to performall the functions the cell requires. To coordinatethese functions, lipid composition of cellularmembranes is tailored to suit their specialized tasks. In this review,we describe the general mechanisms of membrane?protein interactions and relate them to some of the molecularstrategies organisms use to adjust the membrane lipid composition in response to a decrease in environmentaltemperature. While the activities of all biomolecules are altered as a function of temperature, thethermosensors we focus on here are molecules whose temperature sensitivity appears to be linked to changesin the biophysical properties of membrane lipids. This article is part of a Special Issue entitled: Lipid?proteininteractions.","palabras_clave":"Bilayer|Bacteria|Thermosensor|Kinase"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18960,"idioma_id":4,"titulo":"The novel desmopressin analogue [V4 Q5 ]dDAVP inhibits angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models","resumen":"Desmopressin (dDAVP) is a safe haemostatic agent with previously reported antitumour activity. It acts as a selective agonist for the V2 vasopressin membrane receptor (V2r) present on tumour cells and microvasculature. The purpose of this study was to evaluate the novel peptide derivative [V4Q5]dDAVP in V2r-expressing preclinical mouse models of breast cancer. We assessed antitumour effects of [V4Q5]dDAVP using human MCF-7 and MDA-MB-231 breast carcinoma cells, as well as the highly metastatic mouse F3II cell line. Effect on in vitro cancer cell growth was evaluated by cell proliferation and clonogenic assays. Cell cycle distribution was analysed by flow cytometry. In order to study the effect of intravenously administered [V4Q5]dDAVP on tumour growth and angiogenesis, breast cancer xenografts were generated in athymic mice. F3II cells were injected into syngeneic mice to evaluate the effect of [V4Q5]dDAVP on spontaneous and experimental metastatic spread. In vitro cytostatic effects of [V4Q5]dDAVP against breast cancer cells were greater than those of dDAVP, and associated with V2r-activated signal transduction and partial cell cycle arrest. In MDA-MB-231 xenografts, [V4Q5]dDAVP (0.3 &#956;g\/kg, thrice a week) reduced tumour growth and angiogenesis. Treatment of F3II mammary tumour-bearing immunocompetent mice resulted in complete inhibition of metastatic progression. [V4Q5]dDAVP also displayed greater antimetastatic efficacy than dDAVP on experimental lung colonisation by F3II cells. The novel analogue was well tolerated in preliminary acute toxicology studies, at doses &#8805;300-fold above that required for anti-angiogenic\/antimetastatic effects. Our data establish the preclinical activity of [V4Q5]dDAVP in aggressive breast cancer, providing the rationale for further clinical trials.","palabras_clave":"PEPTIDE ANALOG|TREATMENT|METASTASIS|TUMOR VACULARIZATION|BREAST CARCINOMA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18961,"idioma_id":4,"titulo":"New records of Aedes aegypti at the southern limit of its distribution in Buenos Aires province, Argentina","resumen":"Aedes aegypti is the main vector of dengue in the Americas, and its continuously expanding distribution may be a critical factor involved in the constant increase in the incidence and geographic range of dengue disease. The aim of this study was to update the southern distribution of Ae. aegypti in Buenos Aires province, Argentina. We sampled tire deposits in 27 cities in the center and south east of Buenos Aires province, and detected Ae. aegypti in 13 cities. Among them, 10 represent new records for this species, thus expanding the distribution range of Ae. aegypti towards the south in Buenos Aires province. The lowest mean annual temperature where the species was detected was 14.5ºC in Villa Gesell, the most southwards location so far in Buenos Aires province.","palabras_clave":"USED TIRES|GEOGRAPHIC EXPANSION|TEMPERATE REGION|THERMAL LIMITS|DISTRIBUTION|CLIMATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18962,"idioma_id":4,"titulo":"Using Crystallographic Water Properties for the analysis and prediction of Lectin- Carbohydrate complex structures","resumen":"Understanding protein-ligand interactions is a fundamental question in basic biochemistry, andthe role played by the solvent along this process is not yet fully understood. This fact isparticularly relevant in lectins, proteins that mediate a large variety of biological processesthrough the recognition of specific carbohydrates. In the present work, we have thoroughlyanalyzed a non-redundant and well curated set of lectin structures looking for a potentialrelationship between the structural water properties in the apo-structures, and thecorresponding protein-ligand complex structures. Our results show that solvent structureadjacent to the binding sites mimics the ligand oxygen structural framework in the resultingprotein-ligand complex, allowing us to develop a predictive method using a Naive BayesClassifier. We also show how these properties can be used to improve docking predictions oflectin-carbohydrate complex structures both in terms of accuracy and precision, thus developinga solid strategy for the rational design of glycomimetic drugs. Overall our results not onlycontribute to the understanding of protein-ligand complexes, but also underscore the role of thewater solvent in the ligand recognition process. Finally, we discuss our findings in the context oflectin specificity and ligand recognition properties.","palabras_clave":"Cristallography|Lectin carbohydrate structures"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18963,"idioma_id":4,"titulo":"Reference Values of Pulse Wave Velocity in South America: A Call to Action","resumen":"The measurement of pulse wave velocity (PWV) is a wellknown technique currently considered the gold standard of arterial stiffness quantification due to its simplicity, accuracy, reproducibility, and predictive valueHowever, the available contemporary PWV normal values come mostly from multicenter registries obtained in Asia, USA and Europe. In South America, the reference values  used are those derived from a European population, published by the Arterial Stiffness Collaboration Group. Finally, it is important to emphasize the need for  epidemiological studies in South America, to provide reliable  reference values of arterial stiffness, which still remains a  challenge for our region.","palabras_clave":"Pulse Wave Velocity|Epidemiology|South America"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18964,"idioma_id":5,"titulo":"Detección de Brachyspira pilosicoli  y otras especies de Brachyspira en granjas avícolas Argentinas","resumen":"Algunas especies del género Brachyspira como Brachyspira pilosicoli, Brachyspira intermedia y Brachyspira alvinipulli son especies patógenas capaces de producir enfermedad en gallinas ponedoras. En nuestro país la presencia de B. pilosicoli y otras especies de Brachyspira ha sido informada en cerdos y en perros, pero no existen antecedentes de su presencia en aves de corral. Muestras de materia fecal y contenido de ciego de 34 gallinas ponedoras de 4, 12 y 24 meses de edad provenientes de dos establecimientos fueron analizados por medio de aislamiento, pruebas bioquímicas y PCR. B. pilosicoli y Brachyspira spp fueron identificadas en muestras de aves de 12 y 24 meses de edad. Según el conocimiento de los autores este es el primer informe acerca de la presencia del genero Brachyspira y de la especie B. pilosicoli en gallinas ponedoras en nuestro país.","palabras_clave":"Gallinas ponedoras|Brachyspira spp|Brachyspira pilosicoli|diagnóstico|aislamiento|PCR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18965,"idioma_id":4,"titulo":"Polycystin-2 (TRPP2) Regulation by Ca2+ Is Effected and Diversified by Actin-Binding Proteins","resumen":"ABSTRACT Calcium regulation of Ca2+-permeable ion channels is an important mechanism in the control of cell function. Polycystin-2 (PC2, TRPP2), a member of the transient receptor potential superfamily, is a nonselective cation channel with Ca2+ permeability. The molecular mechanisms associated with PC2 regulation by Ca2+ remain ill-defined. We recently demonstrated that PC2 from human syncytiotrophoblast (PC2hst) but not the in vitro translated protein (PC2iv), functionally responds to changes in intracellular (cis) Ca2+. In this study we determined the regulatory effect(s) of Ca2+-sensitive and -insensitive actinbinding proteins (ABPs) on PC2iv channel function in a lipid bilayer system. The actin-bundling protein a-actinin increased PC2iv channel function in the presence of cis Ca2+, although instead was inhibitory in its absence. Conversely, filamin that shares actin-binding domains with a-actinin had a strong inhibitory effect on PC2iv channel function in the presence, but no effect in the absence of cis Ca2+. Gelsolin stimulated PC2iv channel function in the presence, but not the absence of cis Ca2+. In contrast, profilin that shares actin-binding domains with gelsolin, significantly increased PC2iv channel function both in the presence and absence of Ca2+. The distinct effect(s) of the ABPs on PC2iv channel function demonstrate that Ca2+ regulation of PC2 is actually mediated by direct interaction(s) with structural elements of the actin cytoskeleton. These data indicate that specific ABP-PC2 complexes would confer distinct Ca2+-sensitive properties to the channel providing functional diversity to the cytoskeletal control of transient receptor potential channel regulation.","palabras_clave":"calcium|polycystin-2|actin binding proteins"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18966,"idioma_id":4,"titulo":"Poly(amide-triazole)s obtained by regioselective, microwave-assisted click polymerization of bio-based monomers","resumen":"The Cu(I)-catalyzed, microwave-assisted click polymerization of bio-based -azide--alkyne monomers  afforded, with high regioselectivity, stereoregular poly(amide-triazole)s. The monomers were prepared  starting from d-glucono-1,5-lactone as a renewable resource. The synthetic route involves the selective  protection of this sugar lactone with formaldehyde to give a gluconic acid derivative, which was  subjected to amidation of the carboxylic acid function with alkynylamines (2-propynyl, 3-butynyl,  and 4-pentynylamines) and substitution of the primary hydroxyl group by azide. The regioselective  click polymerization of these AB-type alkyne\/azide monomers led to a series of linear biosourced  poly(amide-triazole)s containing mostly (>95%) 1,4-disubstituted triazole linkages. In contrast, the thermal,  metal-free click polymerization led to random distribution of 1,4- and 1,5-disubstituted triazoles  in the polymer backbone. The length of the methylene chain linked to the amide of the monomer and  the cycloaddition regioselectivity strongly affected the properties of the materials, mainly the Tg values,  which were unexpectedly high.","palabras_clave":"Biomaterials|Click polymerization|Polytriazole|Carbohydrate"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18967,"idioma_id":4,"titulo":"Occurrence of Epichloë fungal endophytes in the sheep-preferred grass Hordeum comosum from Patagonia","resumen":"Grazing by exotic herbivores on native vegetation in Patagonian steppes has led to the deterioration of forage resources, where grasses are replaced by shrubs and preferred grasses by non-preferred ones. In this region, Hordeum comosum is one of the widely spread native-grasses highly preferred by sheep. Contrary to other preferred grasses, H. comosum establishes symbiosis with vertically-transmitted fungi of genus Epichloe. However, the level of incidence of the fungus and the phylogenetic diversity of the endophyte remained unclear. We found that endophyte incidence ranged from 0 to 100%, with higher incidence in populations from more arid sites. This would suggest an endophyte-conferred drought tolerance to host. Although the isolates presented several morphological differences, phylogenetic analyses of tubB and tefA genes separated them into only two lineages. One of these lineages was Epichloe tembladerae, the most common endophyte in temperate grasses of southern South America. Strikingly, the other lineage was a hybrid between Epichlo?e typhina and Epichlo?e amarillans detected for the first time in this part of the world and opening new questions about the grass-endophyte co-evolution. These results represent a starting-point in the potential use of fungal endophytes in breeding programs and natural grassland restoration in marginal environments.","palabras_clave":"NATIVE FORAGE SPECIES|PATAGONIA|PHYLOGENY|INCIDENCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18968,"idioma_id":4,"titulo":". Small mammals along SW-Atlantic marshes: diversity correlates with inland habitats but abundance correlates with marsh characteristics","resumen":"Tidal marshes arenarrow wetlands distributed worldwide between the ocean and a variety ofinland-habitats. The high diversity of interacting terrestrial habitats mayinfluence terrestrial species composition and abundance in marshes. Weinvestigated if characteristics of small mammal assemblages inhabiting theSouth-West-Atlantic (SWA) marshes are influenced by marsh characteristics, orif they vary in relation to changes in the inland biogeographic context. Samplingat five-Spartina marshes across the SWA-coast showed that plant cover, richness andheight (ANOVA analysis) and small mammal assemblages (PERMANOVA analysis) differedbetween habitats (marsh or inland) depending on the site. Generalized LinearModels (GLMs) showed that abundance of small mammals in marshes is related tovegetation cover and diversity. However, its richness was related to therichness of small mammal at the inland habitats. In fact, species present ineach marsh were also recorded in adjacent inland habitats. Species compositiondiffered among similar marshes surrounded by different landscapes, while thosein the same landscape did not. Consequently, regional abundance of smallmammals in SWA-marshes is consistent with ecological sorting of abundance rangesalong environmental gradients (e.g., plant-cover and richness). In contrast,landscape composition and configuration strongly affect marsh small mammalspecies assemblages, even if the marsh habitats are quite similar.","palabras_clave":"BIODIVERSITY|SPARTINA MARSHES|SMALL MAMMAL|SOUTHWEST ATLANTIC COASTLINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18969,"idioma_id":4,"titulo":"Effect of Spartina alterniflora Loisel, 1807 on growth of the stout razor clam Tagelus plebeius (Lightfoot, 1786) in a SW Atlantic estuary","resumen":"        Aquatic organisms that produce epibenthic structures  such as saltmarsh plants play key roles in habitat functioning through their  ecosystem engineering effects. Intertidal Spartina species are well  known for modifying tidal hydrodynamic and sediment processes, affecting  cohabiting infaunal organisms. The stout razor clam Tagelus plebeius is  an infaunal filter-feeding species that inhabits a broad range of mudflats (MF)  and Spartina saltmarshes (SM) along the American Atlantic coast. Through  descriptive and experimental approaches conducted at the Bahía Blanca estuary  (Argentina, 38º 47?S, 62º 20?W),  we evaluated ecosystem engineer effects of Spartina alterniflora (due to  changes in sediment and water characteristics) on somatic and shell growth of T.  plebeius. Comparison of bulk sediment parameters indicated that the sediment  is more easily eroded in the SM than in the MF, but softer in the latest. In  addition, food supply for clams (i.e., total particulate organic matter) was  higher in the MF although food quality (i.e., percentage of organic matter in  the water column) was in general higher in SM. Shell growth was higher but clam  condition index (CI) was lower in the MF, and the opposite pattern was found in  the SM. These results represent an uncoupling between shell and somatic growth  with a positive effect of S. alterniflora on the CI of clams. Nevertheless,  results of field experiments manipulating stems and roots of plants separately  suggested that the effect of Spartina on clam?s CI was not due to the  structural changes generated by plant presence itself, although a better food  quality in the SM may be related to the larger clams CI.  ","palabras_clave":"Spartina alterniflora|Tagelus plebeius|ecosystem engineering|shell growth|somatic growth"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18970,"idioma_id":4,"titulo":"Modeling the interference effect in X-ray coherent scattering by the inclusion of experimental form factors in PENELOPE","resumen":"In this work we assess a simple strategy for having at one?s disposal a reliable Monte Carlo simulation tool based on the PENELOPE code, for modeling the interference effects of coherent scattering. We implemented an approach based on the inclusion of experimental values of form factors in the definition of the differential cross section for coherent scattering, without changing the source code. In this sense, theoretical-experimental hybrid tables of form factors have been constructed for materials of biomedical interest: water, PMMA, glandular tissue and adipose tissue. A self-consistency test to assess the use of the constructed hybrid tables was performed successfully. The results of this work are also in good agreement with numerical and experimental results reported in the literature. As a conclusion, the use of hybrid tables in PENELOPE is a suitable approach to improve the description of X-ray coherent scattering in cases where structure effects are relevant like in low-energy X-ray imaging.","palabras_clave":"EXPERIMENTAL FORM FACTORS|HYBRID TABLES OF FORM FACTORS|PENELOPE CODE|XRAY COHERENT SCATTERING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18971,"idioma_id":4,"titulo":"Energetic topography effects on the collective motion of interacting adsorbed particles","resumen":"Collective diffusion of particles with repulsive nearest-neighbor interactions on bivariate surfaces is studied through Monte Carlo simulation, in the framework of the Kubo?Green theory. Shallow and deep adsorbing sites form l×ll×l patches distributed at random or in chessboard-like ordered domains on a two-dimensional square lattice. The influence of the energetic correlation and the lateral interactions on the jump and collective diffusion coefficients are analyzed by simulating the coverage fluctuations in the grand canonical ensemble and the mean-square displacements of particles in the canonical ensemble. The combination of topography and lateral coupling is shown to produce interesting effects such as different filling regimes as well as strong effects on the coverage dependence of the transport coefficients.","palabras_clave":"Adsorsión|Difusión|Simulación por Monte Carlo|Superficies Heterogéneas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18972,"idioma_id":4,"titulo":"Pharmacokinetics of cefuroxime after intravenous, intramuscular and subcutaneous administration to dogs","resumen":"Cefuroxime pharmacokinetic profile was investigated in 6 Beagle dogs after single intravenous, intramuscular and subcutaneous administration at a dose rate of 20 mg\/kg. Blood samples were withdrawn at predetermined times over a 12 hours period. Cefuroxime plasma concentrations were determined by HPLC. Peak plasma concentration (Cmax), time to peak plasma concentration (Tmax) and bioavailability for the intramuscular and subcutaneous administration were 22.99±7.87 µg\/mL, 0.43±0.20 h and 79.70±14.43% and 15.37±3.07 µg\/mL, 0.99±0.10 h and 77.22±21.41%, respectively. Elimination half-lives and mean residence time for the intravenous, intramuscular and subcutaneous administration were 1.12±0.19 h and 1.49±0.21 h; 1.13±0.13 and 1.79±0.24 h; and, 1.04±0.23 h and 2.21±0.23 h, respectively. T>MIC, considering a MIC of 1 µg\/mL was 11 h for intravenous and intramuscular administration and 12h for the subcutaneous route. When a MIC of 4 µg\/mL is considered, T>MIC for intramuscular and subcutaneous administration was estimated in 8 h.","palabras_clave":"Antimicrobials|Cephalosporins|Cefuroxime|Pharmacokinetics|Dogs"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18973,"idioma_id":4,"titulo":"Biocatalytic approaches applied to the synthesis of nucleoside prodrugs","resumen":"Nucleosides are valuable bioactive molecules, which display antiviral   and antitumour activities. Diverse types of prodrugs are designed to   enhance their therapeutic efficacy, however this strategy faces the   troublesome selectivity issues of nucleoside chemistry. In this context,   the aim of this review is to give an overview of the opportunities   provided by biocatalytic procedures in the preparation of nucleoside   prodrugs. The potential of biocatalysis in this research area will be   presented through examples covering the different types of nucleoside   prodrugs: nucleoside analogues as prodrugs, nucleoside lipophilic   prodrugs and nucleoside hydrophilic prodrugs.","palabras_clave":"BIOCATALYSIS|NUCLEOSIDES|NUCLEOTIDES|PRODRUGS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18974,"idioma_id":4,"titulo":"Analysis and Selection of Operating Parameters of an Evolutionary Algorithm for Muscle and Bone Segmentation","resumen":"In the field of medical image segmentation, musclessegmentation is a problem that has not been fully resolvedyet. This is due to the fact that the basic assumption of imagesegmentation, which asserts that a visual distinction should existbetween the different structures to be identified, is infringed.As the tissue composition of two different muscles is the same,it becomes extremely difficult to distinguish one another if theyare near. We have developed an evolutionary algorithm whichselects the set and the sequence of morphological operators thatbetter segments muscles and bones from an MRI image. Theoperation of evolutionary algorithms is influenced by a numberof working parameters which determine the efficiency as well asthe quality of the results obtained.The objective of this work is toselect the set of working parameters which allows the developedevolutionary algorithm to obtain the set of morphological operatorsthat segment muscles and bones with the higher qualityand efficiency. The working parameters selected for each muscleand bone were able to obtain high matching values betweenthe segmented regions using the developed algorithm and thesame regions segmented manually by a medical expert. In furtherwork it is expected to perform the segmentation of a set ofmagnetic resonance images with the developed evolutionary algorithmand the working parameters selected in this work, thiswill allow to identify more accurately the ability of the evolutionaryalgorithm to obtain the set of morphological operatorsthat accurately segment muscles and bones from an mri image.","palabras_clave":"Image Segmentation|Evolutionary Algorithms|MRI|Anatomic Musculoskeletal Models"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18975,"idioma_id":4,"titulo":"The social value of biodiversity and ecosystem services from the perspectives of different social actors","resumen":"        Ecology and Society está indizada en: Thompson Scientific (ISI),Web of Science, Expanded Science Citation Index, Current Contents, Thompson ScientificBIOSIS, Biological Abstracts and Zoological Records, Public Affairs InformationService International (PAIS), Cambridge Scientific Abstracts, BiologicalSciences Database, DOAJ, CAB Abstracts, EBSCO Publishing, Online Access toResearch in the Environment (OARE).------------------------------A vast literature is  now available on ecosystem services (ES), their potential as a tool for  analyzing intertwined processes of ecological and social change, and their  monetary valuation. Much less is known about the social value of different ES  for different social actors (SA), and their links with specific components of  biodiversity. Here we unpack the social aspects of an interdisciplinary and  multi-SA methodology that allows us to assess how different SA perceive and  value different ES, and how they associate them with different components of  biodiversity, ecological attributes and ecosystem types. We apply the  methodology to a study area in the Great Chaco region of South America,  presenting original social-ecological information from the field. Being affected  by the rapid and widespread expansion of agribusiness over the woody ecosystems  of Southern South America, this location provides a policy-relevant context in  which to test our approach. We  identified six major ecosystem types and five relevant social actors. We  carried out 163 individual in-depth interviews and ran seven single-actor focus  groups. We identified 116 ES which were then aggregated into 22 more general  categories. Although all SA perceived all ecosystem types as  multifunctional, they showed markedly different perceptions of and interests in  the ES provided by them. Subsistence farmers and extension officers valued a  large number of ES primarily provided by the most pristine ecosystems. Members  of conservation agencies and policymakers also identified a wide range of ES,  spanning all ecosystem types. However, large farmers and cattle ranchers  recognized a dependency on only a small number of ES. Therefore, the rapid  expansion of agribusiness occurring in this region is a threat to a large  number of ES considered valuable by a wide range of SA. Without necessarily  having to resort to monetary valuation, our methodology provides a rigorous  quantitative-qualitative way to compare the perspective of different SA,  including scientists, and is thus useful for social-ecological assessment and  action.  ","palabras_clave":"ecosystem services|land use change|social valuation|interdisciplinary research"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18976,"idioma_id":5,"titulo":"Test de Raven: actualización de baremos en adolescentes argentinos y análisis del Efecto Flynn","resumen":"    Se  presentan los resultados obtenidos en la construcción de normas actualizadas  del Test de Matrices Progresivas de Raven, Escala General, para la ciudad de La  Plata, Argentina; y su comparación con las obtenidas en los años 1964 y 2000.    Se seleccionó  una muestra de 1049 sujetos de ambos sexos, de 13 a 18 años de edad, alumnos de  educación secundaria. El instrumento fue administrado colectivamente y sin  límite de tiempo.    Los resultados  se analizaron en tres grupos de edad y se compararon con los baremos anteriores.    En relación a  la tipificación del año 2000, en la que se constató el efecto Flynn respecto de  las normas de 1964, se observó un amesetamiento y leve descenso de los puntajes  directos necesarios para alcanzar el rendimiento promedio. La variabilidad de  los puntajes es similar en los grupos de edad. Se constató que a mayor edad de  los sujetos, mejor es su rendimiento.   ","palabras_clave":"RAVEN|BAREMO|EFECTO.FLYNN|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18977,"idioma_id":4,"titulo":"Chromatographic Characterization and Process Performance of Column-Packed Anion Exchange Fibrous Adsorbents for High Throughput and High Capacity Bioseparations","resumen":"Fibrous materials are prominent among novel chromatographic supports for the separation and purification of biomolecules. In this work, strong anion exchange, quaternary ammonium (Q) functional fibrous adsorbents were evaluated with regards to their physical and functional characteristics. A column packed with Q fibrous adsorbent illustrated the good column packing efficiency of theoretical plate height (H) values and higher permeability coefficients (>0.9 × 10&#8722;7 cm2) than commercial adsorbents. For pulse experiments with acetone and lactoferrin as tracers under nonbinding conditions, the total porosity (for acetone) and the interstitial porosity (for lactoferrin) measured 0.97 and 0.47, respectively. The total ionic capacity of the chemically-functionalized Q fiber was 0.51 mmol\/mL. The results indicated that the Q fiber had a static binding capacity of 140 mg\/mL and a dynamic binding capacity (DBC) of 76 mg\/mL for bovine serum albumin (BSA) and showed a linearly-scalable factor (~110 mL) for a column volume with high capacity and high throughput. Furthermore, this adsorptive material had the ability to bind the high molecular weight protein, thyroglobulin, with a capacity of 6 mg\/mL. This work demonstrated the column-packed Q fibrous adsorption system as a potential chromatography support that exhibits high capacity at higher flow rates.","palabras_clave":"FIBROUS ADSORBENT|COLUMN PACKING|PERMEABILITY COEFFICIENT|DYNAMIC BINDING CAPACITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18978,"idioma_id":5,"titulo":"Lina Bo Bardi, cuando el racionalismo toca tierra (americana)","resumen":"La ortodoxia elabora reglas y regimenta las artes, pero nunca brinda comodidad. Ser ortodoxo ayuda a entrar en los libros de historia en cualquiera de las artes, pero rara vez una obra clásica es amable con el ciudadano. Hay que ser un verdadero maestro para entender a fondo las leyes formales de cualquier movimiento y saber cómo distorsionarlas para lograr ese confort que hace que una casa sea vivible, para encontrar el umbral entre la racionalidad universal que viene proponiéndose desde la Ilustración y la belleza proveniente de las particularidades de cada región del planeta.Lina Bo Bardi, arquitecta nacida en Roma en 1914 y  emigrada a Brasil en 1946, supo cruzar ese umbral. Como caso ejemplar de esa actitud podemos hablar de la Casa de Vidrio diseñada y construida por y para ella y su esposo en San Pablo en 1951, solamente un año posterior a la casa Farnsworth de Mies ?el paradigma de la casa de cristal- y que antecede en cinco años a la fusión musical que iba a poner a Brasil en el centro del mundo, la bossa nova, con quien comparte un ?espíritu de la época? brasilero: la encantadora mezcla entre universal y particular.El artículo explora a través de una serie de ejemplos arquitectónicos la obra de Lina Bo Bardi","palabras_clave":"arquitectura |regionalismo|Bo Bardi|Brasil"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18979,"idioma_id":4,"titulo":"Mechanical Effects on the Electronic Properties of a Biphenyl Based Molecular Switch","resumen":"Using a combination of density functional theory and non-equilibrium Green function calculations, the effect of mechanically stretching a biphenyl-based molecular switch bonded to Au electrodes is studied. Thermodynamic and transport properties of the high and low conducting species are analyzed. A disulfide functionality bridging the aromatic rings is used to switch between the high and low conducting species. The potential of such a system as a molecular device has already been proved [J. Phys. Chem. C 2013, 117, 25724]. Mechanically stretching the molecular junction has major effects on both the thermodynamics of the switching reaction and the conductance ratio between the high and low conducting species involved in the molecular switch. It is also shown that the conductance of each individual species can be modulated by means of an external mechanical force, thus providing a dual switching mechanism for the proposed system.","palabras_clave":"BIPHENYL|MOLECULAR ELECTRONICS|DFT|MECHANOCHEMISTRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18980,"idioma_id":5,"titulo":"Activación de polimorfonucleares neutrófilos por UDP-Glucosa extracelular","resumen":"Los nucleótidos purinérgicos extracelulares juegan roles importantes en la señalización celular mediante la activación de sus receptores específicos, expresados en la mayoría de las células. El receptor P2Y14 responde a la señalización por UDP-glucosa extracelular pero no por otros nucleótidos \/nucleósidos purinérgicos libres. Si bien, los polimorfonucleares neutrófilos normales presentan altos niveles de transcriptos del receptor P2Y14,, su función en dichas células ha sido poco investigada. El objetivo de este trabajo fuedemostrar si UDP-Glucosa extracelular induce la quimiotaxis y adhesividad de los neutrófilos. Para ello, se midió la quimiotaxis en polimorfonucleares eutrófilos de: a) pacientes con leucocitosis y neutrofilia (n=10), b) individuos sanos (n=10), c) neutrófilos normales pre-incubados con suero de individuos sanos(n=20) y d) neutrófilos normales pre-incubados con suero de pacientes con artritis reumatoidea (n=17). El control basal se realizó con neutrófilos preincubados con RPMI. También se ensayó la adhesividad de neutrófilosnormales al vidrio. En ambos procedimientos se utilizaron como agonistas, UDP-Glucosa y fMLP. Los resultados obtenidos indicaron que, en los grupos a y b los valores de quimiotaxis inducida por fMLP fueron similares, mientras que, la inducida por UDP-Glucosa fue superior en el grupo a. En el grupo c, fMLP mostrómayor estimulación que UDP-Glucosa, en tanto que, en neutrófilos normales preincubados con suero de pacientes con artritis reumatoidea (grupo d) la quimiotaxis inducida por ambos agonistas fue similar. Cabe destacar que UDP-Glucosa presentó mayor actividad quimiotáctica en neutrófilos normales preincubados con suero de pacientes con artritis reumatoidea, respecto a los preincubados con suero normal. La adhesividad al vidrio de neutrófilos normales, fue mayor con UDP-Glucosa que con fMLP. En conclusión, estos resultados sugieren que la UDP-Glucosa como agonista extracelular, tiene capacidad de generar respuestas fisiológicas en los neutrófilos, tales como la activación de la quimiotaxis y la adhesividad, donde la quimiotaxis se hace más evidente frente a condiciones inflamatorias previas.","palabras_clave":"UDP-Glucosa|PMN|Quimiotaxis|Inflamacion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18981,"idioma_id":5,"titulo":"Protocolo IPv6 para la realización de Video Conferencias","resumen":"Esta línea de Investigación y Desarrollo se basa en la construcción de una solución integral en la que se combina el desarrollo de un software específico para Videoconferencias nativo para Ipv6, implementado en un hardware dedicado. El objetivo es contar con una solución autónoma que permita ser conectada a cualquier monitor o televisor para ser utilizada al momento de hacer una Videoconferencia sin necesidad de contar con equipamiento adicional. La ventaja además de la autonomía será el tamaño y costo final de la solución, en el presente artículo se expondrá la forma en que se propone implementarse.","palabras_clave":"IPV6|STREAMING DE VIDEO|RASPBERRY PI|VIDEOCONFERENCIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18982,"idioma_id":4,"titulo":"AFLP characterization of three argentine Coprotus species","resumen":"AFLP methodology was applied to characterize three Coprotus species (C. lacteus, C. niveus, C. sexdecimsporus) so as to estimate the levels of polymorphism within species, to analyze the phenetic relationships among them, and to contrast the AFLP findings to those of a previous RAPD study. The high number of AFLP bands obtained with the six assayed primers allowed us to detect intra-specific variability. The genetic variability within species obtained using AFLP (measured in terms of percentage of polymorphic loci) was two to three times higher than those obtained by RAPD. The phenograms generated by AFLP markers grouped all strains of the same species into three defined clusters, and a higher association between C. lacteus and C. sexdecimsporus was also observed. The AFLP technique could become a powerful tool for genera such as Coprotus, in which a high intra-specific homogeneity does not allow detection of genetic variability using other PCR-based markers.","palabras_clave":"ASCOMYCOTA|MOLECULAR MARKERS|COPROPHILOUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18983,"idioma_id":4,"titulo":"Role Of Probiotics And Functional Foods In Health: Gut Immune Stimulation By Two Probiotic Strains And A Potential Probiotic Yoghurt","resumen":"There are numerous reports that show the benefices on the health attributed to the probiotic consumptions. Most of the studies were performed using animal models and only some of them were validated in controlled human trials. The present review is divided in two sections. In the first section we describe how the probiotic microorganisms can interact with the intestinal epithelial cells that are the first line of cell in the mucosal site. Then we describe same beneficial effects attributed to of the probiotic administration, principally on the immune system and the intestinal barrier in different experimental mice models like enter pathogen infection, malnutrition, cancer and intestinal inflammation. In the last section there is a brief revision of some controlled trials and prospective investigations showing the effectiveness of probiotics or fermented products in different pathologies reported during the last years (2009- 2013).&nbsp;","palabras_clave":"MUCOSAL IMMUNITY|PROBIOTIC|PROBIOTIC CLAIMS|PROBIOTIC FERMENTED MILK|SYSTEMIC IMMUNITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18984,"idioma_id":4,"titulo":"Fucosylated clusterin in semen promotes the uptake of stress-damaged proteins by dendritic cells via DC-SIGN","resumen":"ABSTRACTStudy question: Could semen clusterin play a role in the uptake of stress-damaged proteins by dendritic cells? Summary answer: Semen clusterin, but not serum clusterin, promotes the uptake of stress-damaged proteins by dendritic cells via DC-SIGN.What is known already: Clusterin is one of the major extracellular chaperones. It interacts with a variety of stressed proteins to prevent their aggregation, guiding them for receptor-mediated endocytosis and intracellular degradation. The concentration of clusterin in semen is almost 20-fold higher than those found in serum, raising the question about the role of semen clusterin in reproduction. No previous studies have analyzed whether semen clusterin has chaperone activity. We have previously shown that semen clusterin, but not serum clusterin, expresses an extreme abundance of fucosylated glycans. These motifs enable semen clusterin to bind DC-SIGN with very high affinity. Study design, size, duration: In vitro experiments were performed to evaluate the ability of semen clusterin to inhibit the precipitation of stressed proteins, promoting their uptake by dendritic cells via DC-SIGN. Moreover, the ability of semen clusterin to modulate the phenotype and function of dendritic cells were also assessed.Participants\/materials, setting, methods: Clusterin was purified from human semen and human serum. Catalase, bovine serum albumin, glutathione S-transferase, and normal human serum were stressed and the ability of semen clusterin to prevent the precipitation of these proteins guiding them to DC-SIGN expressed by dendritic cells was evaluated by FACS. Endocytosis of stressed proteins was analyzed by confocal microscopy and the ability of semen-clusterin-treated dendritic cells to stimulate the proliferation of CD25+FOXP3+CD4+ T cells was also evaluated by FACS.Main results and the role of chance: Semen clusterin interacts with stressed proteins, inhibits their aggregation and efficiently targets them to dendritic cells via DC-SIGN. Dendritic cells efficiently endocytosed clusterin-client complexes and sorted them to degradative compartments involved in antigen processing and presentation. Moreover, we also found that the interaction of semen clusterin with DC-SIGN did not change the phenotype of dendritic cells, but stimulates their ability to induce the expansion of CD25+FOXP3+CD4+ T lymphocytes (p<0.05).Limitations, reasons for caution: All the experiments were performed in vitro, hence the relevance of our observations should be validated in vivo.  Wider implications of the findings: Our results suggest that by inducing the endocytosis of stress-damaged proteins by dendritic cells via DC-SIGN, semen clusterin might promote a tolerogenic response to male antigens contributing to female tolerance to seminal antigens.  Study funding\/competing interest(s): The present research was supported by the Consejo Nacional de Investigaciones Científicas y Técnicas, the Buenos Aires University School of Medicine, and the Agencia Nacional de Promoción Científica y Tecnológica (Argentina). The authors have no conflicts of interest to declare.","palabras_clave":"CLUSTERINA|DENDRITIC|SEMEN|DC-SIGN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18985,"idioma_id":5,"titulo":"La cooperacion del Ejército argentino y brasileño desde fines del siglo XX","resumen":"Este trabajo tiene como objetivo analizar ejercicios combinados del Ejército Argentino y el Ejército Brasileño desde fines del siglo XX. Nos proponemos: 1) Identificar políticas que orientaron su concepción y concreción. 2) Mostrar que en una primera etapa se produjeron ejercicios clásicos o convencionales contra un enemigo estatal que controla un espacio geográfico y, posteriormente, se incorporaron operaciones de apoyo a la comunidad o de asistencia en catástrofes. Sostendremos que desde la década de 1990 la política de defensa argentina se ha manifestado en favor de la construcción de una integración regional en el Mercosur y, más recientemente, en la UNASUR; mientras que la política del Brasil ha promovido la cooperación regional en defensa, procurando con ello preservar una mayor autonomía. Pero esa vocación argentina por la integración ha sido inconstante en sus realizaciones prácticas. En tanto que la más limitada cooperación del Brasil, por el contrario, sostuvo los compromisos asumidos, al menos, en relación con los ejercicios efectuados con el Ejército Argentino.","palabras_clave":"Ejercicios|Cooperación|Enseñanzas|Doctrinas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18986,"idioma_id":4,"titulo":"Multifractal characterisation and classification of bread crumb digital images","resumen":"Adequate models of the bread crumb structure can be critical for understanding flow and transport processes in bread manufacturing, creating synthetic bread crumb images for photo-realistic rendering, evaluating similarities, and establishing quality features of different bread crumb types. In this article, multifractal analysis, employing the multifractal spectrum (MFS), has been applied to study the structure of the bread crumb in four varieties of bread (baguette, sliced, bran, and sandwich). The computed spectrum can be used to discriminate among bread crumbs from different types. Also, high correlations were found between some of these parameters and the porosity, coarseness, and heterogeneity of the samples. These results demonstrate that the MFS is an appropriate tool for characterising the internal structure of the bread crumb, and thus, it may be used to establish important quality properties it should have. The MFS has shown to provide local and global image features that are both robust and low-dimensional, leading to feature vectors that capture essential information for classification tasks. Results show that the MFS-based classification is able to distinguish different bread crumbs with very high accuracy. Multifractal modelling of the underlying structure can be an appropriate method for parameterising and simulating the appearance of different bread crumbs. ","palabras_clave":"Fractal|Multifractal|Image analysis|Feature extraction"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18987,"idioma_id":4,"titulo":"Acoustic Repertoire of Melanophryniscus cupreuscapularis (Ce´spedez and ´Alvarez 2000) (Anura: Bufonidae): Advertisement, Encounter, and Release Calls","resumen":"We describe the vocal repertoire of Melanophryniscus cupreuscapularis, a bufonid toad of the Melanophryniscus stelzneri speciesgroup, which has been recently listed as ??Vulnerable?? by the Asociacio´ n Herpetolo´ gica Argentina. Recordings were obtained in ??Paraje ElPericho´ n,?? a relict of Schinopsis balansae ??quebracho?? forest near Corrientes City, Argentina, in September 2007. We provide data on thestructure and frequency of three kinds of vocalization: the advertisement, the encounter, and the release calls. We found that the advertisementcall is formed by two distinct sections: a first segment consisting of short emissions, usually grouped, and a fast trill. We found that theencounter call is also composed of two segments but that the number of simple emissions in the first segment is greater and more variable (6?60)than in the advertisement call, and the emissions are ungrouped. Although the dominant frequency was similar to the advertisement call, theencounter call frequency was 2,184 Hz (range: 1,832?2,482). The release call is composed of isolated emissions emitted at a lower frequency(1,798 Hz, range: 1,712?1,926) than are the other calls. The structure of the advertisement call was similar to that of other species of the stelzneri?1 group.","palabras_clave":"AMPHIBIANS|BIOACOUSTIC|MELANOPHRYNISCUS CUPREUSCAPULARIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18988,"idioma_id":4,"titulo":"Oil biogenesis and antioxidant compounds from 'Arauco' olive (Olea europaea L.) cultivar during fruit development and ripening","resumen":"'Arauco' is the only olive (Olea europaea L.) cultivar recognized from Argentina in the World Catalogue of Olive Varieties. Drupes from this cultivar were handpicked at different stages of fruit development and ripening-referred to as days after full flowering (DAFF)-and analyzed to assess the oil accumulation pattern, and the dynamic of the changes in fatty acid, tocopherol, squalene, and phenolic compositions. The most intense oil accumulation period occurred approximately between 80 DAFF (pit hardening) and 150 DAFF (beginning of fruit maturation). Oleic acid content increased rapidly until reaching the maximum concentration (71.4%) approximately 80 DAFF, thus indicating that the most active biosynthesis period occurred at early fruit growth stages. Later, oleic acid content decreased gradually, almost linearly, to 62% at the final sampling point (215 DAFF). The dynamic of tocopherol accumulation showed a trend characterized by high amounts of the &#945;- and &#947;-isoforms in very young drupes, a pronounced decrease during fruit development, and little or no change during the fruit maturation period. The developing drupes were found to accumulate significant amounts of squalene (up to 12 500mg\/kg of dry weight at 96 DAFF), but squalene dropped strongly after the beginning of fruit ripening. Whatever the stage of fruit development, secoiridoids were the major phenolic components. On the basis of the evolution of the analytical parameters studied, the best stage for processing 'Arauco' fruits for oil production seems to be that where maturity index is higher than 1 and lower than 2. Practical applications: The study focuses on biochemical aspects of oil biogenesis and minor antioxidant compounds from the cv. 'Arauco' during fruit ontogeny. The results show that this cultivar has profitable characteristics for commercial production of VOO. From a practical standpoint, results also contribute to better assessment of harvest time. Findings remark on the convenience of harvesting early (at a low fruit maturity index) to get the best combination of oil quantity and quality.","palabras_clave":"Antioxidant compounds|Fatty acid composition|Fruit ontogeny|Oil biogenesis|Olive (cv. 'Arauco')"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18989,"idioma_id":5,"titulo":"Distribución espacial de la evapotranspiración del cultivo de referencia y de la precipitación efectiva para las provincias del centro-noreste de Argentina","resumen":"Este trabajo se enmarca en el Acuerdo FAO-INA Identificación de potenciales nuevas áreas de regadíos y áreas de riego complementario en la cuencas de la zona nordeste de Argentina?. Sus objetivos: conocer la evapotranspiración mensual del cultivo de referencia (ETo), analizar su variabilidad y representarla espacialmente. El estudio comprendió el centro-noreste de Argentina, utilizó el programa CROPWAT 8.0 - FAO y los datos climáticos fueron obtenidos de la base CLIMWAT 2.0. La información se volcó en formato gráfico utilizando Arc View 3.2ª y las variables de interés se interpolaron mediante el método Kriging. Los resultados muestran: (a) la estación con mayor ETo anual es Santiago del Estero: 1767 mm.año-1; la mínima ETo (1150 mm.año-1) se observa en Loreto (Misiones), (b) la ETo media del área de estudio para enero varía entre 160 y 200 mm.mes-1 y la de julio está comprendida entre 35 y 90 mm.mes-1, (c) en el NE de Córdoba la ETo media de enero varía entre 165 y 185 mm.mes-1, mientras que en julio, la variabilidad es menor y (d) la lluvia para un año hidrológico medio varía entre 605 y 1825 mm.año-1 con una precipitación efectiva comprendida entre 500 y 1400 mm.año-1 aumentando hacia el noreste.","palabras_clave":"necesidad de riego|demanda hídrica de los cultivos|planificación del uso del agua|riego complementario\/suplementario|productividad"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18990,"idioma_id":4,"titulo":"Label-free and redox proteomic analyses of the triacylglycerol-accumulating Rhodococcus jostii RHA1","resumen":"The bacterium Rhodococcus jostii RHA1 synthesizes large amounts of triacylglycerols (TAG) under conditions of nitrogen starvation. To better understand the molecular mechanisms behind this process, we performed proteomic studies in this oleaginous bacterium. Upon nitrogen starvation, we observed a re-routing of the carbon flux towards the formation of TAG. Under these conditions, the cellular lipid content made up more than half of the cell?s dry weight. On the proteome level, this coincided with a shift towards non-glycolytic carbohydrate-metabolizing pathways. These pathways (Entner-Doudoroff and pentose-phosphate shunt) contribute NADPH and precursors of glycerol-3-phosphate and acetyl-CoA to lipogenesis. The expression of proteins involved in the degradation of branched-chain-amino acids and the methyl malonyl-CoA pathway probably provided propionyl-CoA for the biosynthesis of odd-numbered fatty acids, which make up almost 30% of RHA1 fatty acid composition. Additionally, lipolytic and glycerol-degrading enzymes increased in abundance, suggesting a dynamic cycling of cellular lipids. Conversely, abundance of proteins involved in consuming intermediates of lipogenesis decreased. Furthermore, we identified another level of lipogenesis regulation through redox-mediated thiol modification in R. jostii. Enzymes affected included acetyl-CoA carboxylase and a &#946;-ketoacyl-[ACP] synthase II (FabF). An integrative metabolic model for the oleaginous RHA1 strain is proposed based on our results.","palabras_clave":"lipids|proteomics|Rhodococcus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18991,"idioma_id":4,"titulo":"CLIMATIC DROPLET KERATOPATHY: AN OLD DISEASE IN NEW CLOTHES","resumen":"Climatic droplet keratopathy (CDK) is an acquired and potentially handicapping cornea degenerative disease that is highly prevalent in certain rural communities around the world. It predominantly affects males over their forties. It has many other names such as Bietti?s band-shaped nodular dystrophy, Labrador keratop- athy, spheroidal degeneration, chronic actinic keratopathy, oil droplet degener- ation, elastoid degeneration and keratinoid corneal degeneration. CDK is characterized by the haziness and opalescence of the cornea?s most anterior layers which go through three stages with increasing severity. Globular deposits of different sizes may be histopathologically observed under the corneal epithelium by means of light and electron microscopy. The coalescence and increased volume of these spherules may cause the disruption of Bowman?s membrane and the elevation and thinning of the corneal epithelium. The exact aetiology and pathogenesis of CDK are unknown, but they are possibly multifactorial. The only treatment in CDK advanced cases is a corneal transplantation, which in different impoverished regions of the world is not an available option. Many years ago, the clinical and histological aspects of this disease were described in several articles. This review highlights new scientific evidence of the expanding knowledge on CDK?s pathogenesis which will open the prospect for new therapeutic interventions.","palabras_clave":"CLIMATIC DROPLET KERATOPATHY|ASCORBATE|ENVIRONMENT|HUMAN|UV-B"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18992,"idioma_id":4,"titulo":"Climatic droplet keratopathy in Argentina: Involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions","resumen":"Climatic droplet keratopathy (CDK) is a degenerative corneal disease of unknown etiology. We described CDK for the  rst time in Latin America in the Argentinean Patagonia (El Cuy). A deeper knowledge of CDK pathogenic mechanisms will provide new therapeutic strategies. For that reason we investigated the prevalence of CDK in El Cuy and its existence in other 3 provinces with similar climate. Patients eyes were examined, habits throughout lives were inquired about, and serum ascorbate (sAA) was determined. All individuals work outdoors for most of the day. All regions had normal O3 levels. Individuals from regions 1, 2, and 3 had very low consumption of vegetables\/fruits and low sAA levels. Conversely, region 4 individuals had balanced diet and higher sAA concentrations. CDK was only found in region 3 where individuals had partial de ciency of sAA and did not use eye protection. No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection. No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection. To summarize, the CDK existence was related not only to climate but also to the dietary habits and lack of protection from sunlight.","palabras_clave":"CLIMATIC DROPLET KERATOPATHY|ASCORBIC ACID|ARGENTINA|UV-B RADIATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18993,"idioma_id":5,"titulo":"El rol de las creencias en los modelos de aprendizaje auto-regulado y su relación con el aprendizaje del dibujo","resumen":"Resumen  El rol de las creencias en los modelos de aprendizaje auto-regulado y su relación con el aprendizaje del dibujo  Se evaluó el nivel de objetividad del juicio que los alumnos hacen acerca de su habilidad para el dibujo a mano alzada, al comienzo de sus estudios y la relación entre la creencia y los componentes del aprendizaje auto-regulado.  La muestra de 300 sujetos está compuesta por alumnos que cursan el Ciclo Básico Común en la Facultad de Arquitectura Diseño y Urbanismo de la Universidad de Buenos Aires. La objetividad de la creencia en la propia habilidad se ha verificado parcialmente, para el caso del grupo de sujetos que se manifiestan negativamente al respecto. En el grupo que se evaluó erróneamente como bueno o muy bueno, este error parece ligarse con un estilo de aprendizaje superficial, lo que hace pensar que estos sujetos tienen menos conciencia de sus límites. A partir de los resultados se discute la relación entre agentividad y creencia de autoeficacia específica y se señalan líneas de intervención pedagógica.","palabras_clave":"CREENCIAS|APRENDIZAJE AUTORREGULADO|DIBUJO|EDTILOS DE APRENDIZAJE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18994,"idioma_id":5,"titulo":"Rebeliones indígenas, movimientos socioreligiosos y procesos de territorialización. El Dios Luciano y la Iglesia Evangélica Unida en Argentina","resumen":"El objetivo de este trabajo es analizar los movimientos socioreligiosos que tuvieron lugar en el Gran Chaco a principios del siglo XX y el proceso de gestación, consolidación y vigencia de la Iglesia Evangélica Unida a partir de la década de 1940, como momentos significativos en la serie de respuestas al sometimiento de los pueblos indígenas del Chaco argentino, producto de la conquista y la colonización. Para ello se reflexiona sobre el modo en que lo religioso y lo político, lo mítico y lo racional se articulan en relación a estrategias de reconstrucción identitaria y redimensionalización territorial en el contexto de la búsqueda de concreción de los derechos indígenas. Proponemos pensar las rebeliones indígenas en el contexto de los denominados movimientos sociales, resaltando su contenido político y sin limitarnos a la idea de nuevos movimientos sociales.","palabras_clave":"PUEBLOS INDÍGENAS|RELIGIÓN|TERRITORIOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18995,"idioma_id":4,"titulo":"ON THE SEARCH OF MORE STABLE SECOND-ORDER LATTICE-BOLTZMANN SCHEMES IN CONFINED FLOWS","resumen":"The von Neumann linear analysis, restricted by a heuristic selection of wave-number vectors was applied to the search of explicit lattice Boltzmann schemes which exhibit more stability than existing methods. The relative stability of the family members of quasiincompressible collision kernels, for the Navier-Stokes equations in confined flows, was analyzed. The linear stability analysis was simplified by assuming a uniform velocity level over the whole domain, where only the wave numbers of the first harmonic normal to the flow direction were permitted. A singular equilibrium function that maximizes the critical velocity level was identified, which was afterwards tested in particular cases of confined flows of interest, validating the resulting procedure.","palabras_clave":"Lattice Boltzmann|Stability|Confined flows"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18996,"idioma_id":4,"titulo":"Aquatic Coleoptera from El Cristal Natural Reserve (Santa Fe Province, Argentina)","resumen":"A list of the aquatic Coleoptera collected in El Cristal Natural Reserve is presented. Seventy-eight species included in 36 genera and six families were recorded. Eleven genera are first cited for Santa Fe Province: Copelatus Erichson, Anodocheilus Babington, Bidessodes Régimbart, Bidessonotus Régimbart, Pachydrus Sharp, Laccomimus Toledo & Michat (Dytiscidae), Mesonoterus Sharp (Noteridae), Pelonomus Erichson (Dryopidae), Chaetarthria Stephens, Oocyclus Sharp and Paracymus Thomson (Hydrophilidae). In addition, 18 species are recorded for the first time: Thermonectus succinctus (Aubé), Anodocheilus maculatus Babington, Bidessonotus obtusatus Régimbart, Pachydrus globosus (Aubé), P. obesus Sharp, (Dytiscidae), Hydrocanthus paraguayensis Zimmermann, Mesonoterus laevicollis Sharp, Suphis freudei Mouchamps, Suphisellus curtus (Sharp), S. grammicus (Sharp), S. nigrinus (Aubé) and S. remator (Sharp) (Noteridae), Chaetarthria bruchi Balfour-Browne, Enochrus sublongus (Fall), Berosus paraguayanus Knisch, Derallus altus (Leconte), Oocyclus schubarti Orchymont and Phaenonotum regimbarti Bruch (Hydrophilidae).","palabras_clave":"AQUATIC COLEOPTERA|INVENTORY|HUMID CHACO|BIODIVERSITY|NEOTROPICAL REGION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18997,"idioma_id":5,"titulo":"COSTRUCCION, ADAPTACION Y AJUSTE DEL EXTENSOMETRO LONGITUDINAL","resumen":"SE PROPONE LA CONSTRUCCION Y ADAPTACION DE UN EXTENSOMETRO PARA MEDIR LAS TENSIONES DE CRECIMIENTO DE LAS ESPECIES MADERERAS","palabras_clave":"CONSTRUCCION|ADAPTACION|EXTENSOMETRO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18998,"idioma_id":5,"titulo":"Las redes de parentesco y el gobierno de la ciudad (Mendoza, siglo XVIII). Acerca de 'Las tres casas reinantes de Cuyo' del Prof. Jorge Comadrán Ruiz","resumen":"El artículo Las Tres Casas reinantes de Cuyo, del Prof. Jorge Comadrán Ruiz, prestigioso historiador de la Universidad Nacional de Cuyo y reconocido internacionalmente, sigue siendo un trabajo de referencia, tanto para los estudiosos que realizan una historia social de Mendoza en el siglo XVIII, como para los que se dedican a la historia institucional, y más teniendo en cuenta que las nuevas miradas en la historia jurídico institucional han incorporado a los análisis las prácticas institucionales y sociales, por permitir un conocimiento más acabado de las dinámicas institucionales. Es por esta razón que hemos decidido recuperar Las tres casas reinantes de Cuyo, y reeditarlas con  un estudio introductorio sobre sus aportes a la historia de las redes sociales y a la de las instituciones.","palabras_clave":"POLITICA|SOCIEDAD|REDES|PARENTESCO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":18999,"idioma_id":4,"titulo":"Categorical foundations for structured specifications in Z","resumen":"In this paper we present a formalization of the Z notation and its structuring mechanisms. One of the main features of our formal framework, based on category theory and the theory of institutions, is that it enables us to provide an abstract view of Z and its related concepts. We show that the main structuring mechanisms of Z are captured smoothly by categorical constructions. In particular, we provide a straight- forward and clear semantics for promotion, a powerful structuring technique that is often not presented as part of the schema calculus. Here we show that promotion is already an operation over schemas (and more generally over specifications), that allows one to promote schemas that operate on a local notion of state to operate on a subsuming global state, and in particular can be used to conveniently define large specifications from collections of simpler ones. Moreover, our proposed formalization facilitates the combination of Z with other notations in order to produce heterogeneous specifications, i.e., specifications that are obtained by using various different mathematical formalisms. Thus, our abstract and precise formulation of Z is useful for relating this notation with other formal languages used by the formal methods community. We illustrate this by means of a known combination of formal languages, namely the combination of Z with CSP.","palabras_clave":"Formal Specification|Structured Specifications|Model Based Formal Specification|Category Theory"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19000,"idioma_id":4,"titulo":"Highlights from the 1st ISCB Latin American Student Council Symposium 2014","resumen":"This report summarizes the scientific content and activities of the first edition of the Latin American Symposium organized by the Student Council of the International Society for Computational Biology (ISCB), held in conjunction with the Third Latin American conference from the International Society for Computational Biology (ISCB-LA 2014) in Belo Horizonte, Brazil, on October 27, 2014.","palabras_clave":"-"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19001,"idioma_id":4,"titulo":"Novel Insights into the Evolution and Structural Characterization of Dyskerin Using Comprehensive Bioinformatics Analysis","resumen":"Dyskerin is a conserved nucleolar protein. Several related genetic diseases are caused by defects in dyskerin. We hypothesized that having a comprehensive bioinformatic analysis of dyskerin will help to develop new drugs for this diseases. We predicted protein domains and compared sequences and structures to detect the universe of dyskerin-like proteins. We identified conserved features of shared domains in the three superkingdoms. We analyzed the phylogenetic diversity, confirming that there is a strong structural conservation. Also, we studied the relationship of dyskerin-like proteins with other proteins through an integrative protein&#8722;protein interaction approach. Most of them are conserved among homologous eukaryotic and archaeal proteins. Our results highlighted the preservation of proteins interacting with dyskerin. We identified conserved dyskerin interactor proteins between the different eukaryotes organisms. Furthermore, we studied the existence of dyskerin-like proteins in different species. Also, we compared and analyzed the secondary structure with the hydrophobic profile, confirming that all have hydrophilic properties highly conserved among proteins. The greatest difference was observed in the NTE and CTE regions. Another aspect studied was the comparison and analysis of tertiary structures. In our knowledge, this is the first time that these analyses were performed in such a comprehensive manner.","palabras_clave":"DKCLD|PUA|TruB_N|dyskerin phylogeny|dyskerin-like protein"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19002,"idioma_id":4,"titulo":"'ANALYSIS OF THE RUMEN BACTERIAL DIVERSITY OF CREOLE GOATS UNDER TWO DIFFERENT DIET CONDITIONS USINGq-PCR'","resumen":"Quantitative real time (qPCR) assays was used to determine both the abundance and diversity of bacterialcommunity characterizing rumen of Creole goats for which the diet was switched from alfalfa hay\/corn (AH\/C) tonative forages (NF). Two fistulated goats were routinely fed with AH\/Cdiet for a period of 21 days. Then, goatswere switched to the NF diet for others 21 days. The ruminal contents were sampled at 2 (Day 0), 10 (Day 10) and21 (Day 21) days after the beginning of each diet. One sample per animal was collected after feeding and wasstored for later DNA extraction. Total bacteria, Firmicutes, Actinobacteria, Bacteroidetes and &#947;-Proteobacteriawere quantified by qPCR using primers targeting 16S rRNA gene specific. In relation to diet, total ruminalbacteria were significantly higher in goats fed NF diet (11.75 ± 1.46 x 1010 bacteria g-1) than in those fed AH\/Cdiet (6.39 ± 2.67 x 1010 bacteria g-1). Not significantly differences in concentrations of Firmicutes, Bacteroidetesor &#61543;-Proteobacteria concentrations were observed during feeding experiment. However, Actinobacteria concentration was significantly higher in goats fed FN diet (24.65 ± 5.95 x 105 bacteria g-1 ) than in those fed AH\/C diet (1.73 ± 0.28 x 105 bacteria g-1 ). Within this bacterial phylum, Actinomyces sp, lavobacterium sp and Bifidobacterium sp have been described in the ruminal ecosystem, which could be selected at a high number in goats fed NF diet. Findings from q-PCR analysis suggest that rumen bacterial community of Creole goats was influenced by diet. New bacterial species have been associated with the degradation of the nutritional components in diets in the rumen of these animals.","palabras_clave":"bacterias ruminales|dieta"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19003,"idioma_id":4,"titulo":"Scaling-up from species to ecosystems: How close can we get to actual decomposition?","resumen":"Predicting global changes and their effects on ecosystem functioning has been a central issue of ecology  during the last decades. Scaling-up from species characteristics to ecosystem processes is a common  approach to achieve that goal. However, ecosystem processes are shaped by complex interactions between  biotic and abiotic components, complicating their predictability. We evaluated how close we can  get to ecosystem-level decomposition (i.e. in situ litter mixtures decomposition) based on aggregated  functional traits (calculated as weighted averages of species litter quality and decomposability) in  mountain grasslands patches of central Argentina. We found that aggregated functional traits were not  significantly correlated to in situ decomposition; i.e. contrary to other works, in our system it is not  possible to scale up from species characteristics to ecosystem-level decomposition. This pattern was  consistent when litter quality and decomposability were weighted by either species standing biomass or  by litter input. These two ways of aggregation were highly correlated, indicating that standing biomass  was a good proxy of the contribution that species make to litter layer. Aggregated functional traits were  strongly associated to litter mixtures decomposability (a proxy for community-level decomposition),  indicating that there are no strong interactions among litters of the species decomposing together.  However, litter mixtures decomposability was not correlated to in situ decomposition, showing that  community-level and ecosystem-level decomposition were not related. We suggest that the soil environment  generated by vegetation structure of the different grassland patches could be controlling in situ  decomposition. The prediction of decomposition and nutrient cycling changes associated to land-use  change calls for the consideration of variables which integrate different controls; i.e. not only species  identity and abundance, but also climate and microclimate. In particular, studies combining decomposability  and in situ decomposition could help to more accurately understand and predict the different  mechanisms involved in nutrient and carbon cycling.","palabras_clave":"AGGREGATED FUNCTIONAL TRAITS|IN SITU DECOMPOSITION|LITTER INPUT|MASS RATIO HYPOTHESIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19004,"idioma_id":4,"titulo":"Evaluation of olive flowering at low latitude sites in Argentina using a chilling requirement model","resumen":"Olive production has expanded significantly from the Mediterranean Basin into the New World over the last two decades. In some cases, cultivars of European origin have been introduced at a large commercial scale with little previous evaluation of potential productivity. The objective of this study was to evaluate whether a temperature-driven simulation model developed in the Mediterranean Basin to predict normal flowering occurrence and flowering date using cultivar-specific thermal requirements was suitable for the low latitude areas of Northwest Argentina. The model was validated at eight sites over several years and a wide elevation range (350-1200 m above mean sea level) for three cultivars (?Arbequina?, ?Frantoio?, ?Leccino?) with potentially different chilling requirements. In ?Arbequina?, normal flowering was observed at almost all sites and in all years, while normal flowering events in ?Frantoio? and ?Leccino? were uncommon. The model successfully predicted if flowering would be normal in 92% and 83% of the cases in ?Arbequina? and ?Frantoio?, respectively, but was somewhat less successful in ?Leccino? (61%). When flowering occurred, the predicted flowering date was within ± 7 days of the observed date in 71% of the cases. Overall, the model results indicate that cultivar-specific simulation models may be used as an approximate tool to predict whether individual cultivars will be successful in new growing areas. In Northwest Argentina, the model could be used to identify cultivars to replace ?Frantoio? and ?Leccino? and to simulate global warming scenarios.","palabras_clave":"CHILLING UNIT |DORMANCY|OLEA EUROPAEA|TEMPERATURE|THERMAL TIME"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19005,"idioma_id":4,"titulo":"Iron cycling during the autocatalytic decomposition of benzoic acid  derivatives by Fenton-like and photo-Fenton techniques","resumen":"In the context of our work on the oxidative degradation of a series of hydroxyl derivatives of benzoic acid (HBAs) by Fenton-like and photo-Fenton processes, we present a comprehensive study of the factors that affect the reduction of Fe(III) species, the rate limiting step in the Fenton reaction. We have investigated: (i) the formation of Fe(III)-HBA complexes, (ii) the ability of these complexes to participate in reductive pathways, and (iii) the formation of intermediate products capable of reducing ferric species.  The results show that salicylate-like HBAs form stable bidentate ferric complexes in aqueous solutions at pH 3.0 and that Fe(III) complexation significantly decreases the overall degradation rates in Fenton systems by slowing down Fe(II) production through both dark and photo-initiated pathways. Interestingly, in contrast to ferric complexes of aliphatic carboxylates that undergo a photo-induced decarboxylation upon excitation in the 300?400 nm wavelength range, ferric-salicylate complexes yield Fe(II) and hydroxyl radicals by oxidation of water molecules in the coordination sphere of the metal center. However, their efficiencies are significantly lower than that of the Fe(III) aqua complex. Moreover, Fe(III)-HBA complexes are inert upon excitation of the LMCT bands involving the organic ligand (i.e., 400?600 nm).  As observed for other aromatic compounds, Fe(III)-reducing intermediates formed during the Fenton oxidation of HBAs play a key role in iron cycling. The analysis of the primary oxidation\/hydroxylation products as well as Fe(III)-reduction studies showed that, among dihydroxy aromatic derivatives, hydroquinone-like structures were much more efficient than catechol-like structures for reducing Fe(III). Although all trihydroxy derivatives produced Fe(II), ring opening reactions prevailed under the conditions of the Fenton reaction.  The results of our investigation on the Fenton oxidation of HBA derivatives show that, in each particular case, the complex interplay of the aforementioned factors should be carefully evaluated for developing optimal applications of Fenton processes at a technological level.","palabras_clave":"Hydroxyl radicals|Iron (III) reduction|Iron (III) complexation|Benzoic acid derivatives"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19006,"idioma_id":5,"titulo":"ENSAYOS DE SIMULACIÓN DE DIGESTIÓN GÁSTRICA DE PULPA DE FRAMBUESA FERMENTADA CON DIFERENTES CEPAS DE Lactobacillus plantarum","resumen":"XXXX","palabras_clave":"DIGESTIÓN GÁSTRICA|PULPA DE FRAMBUESA|Lactobacillus plantarum|FERMENTACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19007,"idioma_id":5,"titulo":"EL VOLUNTARIADO COMO EXPERIENCIA INTERDISCIPLINARIA EN LA CONSTRUCCIÓN DE UNA RED SOCIAL PARA PROTECCIÓN DE NIÑOS NACIDOS EN CONDICIONES DE RIESGO","resumen":"RESUMEN  La sobrevida de niños nacidos en condiciones de riesgo bio-psico-social se convirtió en una problemática emergente y compleja  que trasciende el ámbito médico y  requiere un abordaje interdisciplinario para concientizar a la familia y comunidad de su vulnerabilidad.    Un proyecto de voluntariado universitario (VU) permitió realizar intervenciones con docentes y alumnos de distintas facultades. Los resultados no fueron preconcebidos, resultaron de la construcción permanente de los actores. Los propósitos fueron: conciliar la razón científica con la realidad social, fomentar el desarrollo de capacidades funcionales en familias con minusvalías socio-económico-culturales y con un niño nacido en condición de riego (NNCR), fortaleciendo además, redes comunitarias que las protejan.  METODOLÓGIA: Se utilizó el modelo de Investigación-Acción Participativa en un barrio con pobreza y exclusión. Los destinatarios directos fueron NNCR, < de 2 años (N=30), y sus familias; indirecto fue la comunidad. Efectores en terreno fueron estudiantes y docentes universitarios y el equipo de salud del barrio. La población fue identificada en el registro del servicio de seguimiento y del centro médico barrial. Los actores sociales se identificaron con la técnica ?en bola de nieve?. Las actividades comunitarias fueron consensuadas. RESULTADOS: Se logró movilizar y sensibilizar a la comunidad con este grupo de riesgo, haciéndola partícipe de actividades multidisciplinarias con profesionales y estudiantes universitarios. Se valorizó  la importancia del estímulo para el crecimiento y desarrollo infantil. Se establecieron vínculos fuertes con instituciones claves que proyectarán hacia una mejor calidad de vida de esta población. CONCLUSIONES: El VU, al contactar con la realidad social, es generador de valores éticos y solidarios que enriquecen al futuro profesional con una cosmovisión más equitativa. Docentes y estudiantes universitarios pueden aportar a la construcción  interdisciplinar y a la participación social. Se trabajó para despertar conciencia comunitaria respecto  al riesgo de la prematurez,  y de los derechos de estos niños  a un seguimiento especializado.","palabras_clave":"RED SOCIAL|PROTECCIÓN|VOLUNTARIADO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19008,"idioma_id":4,"titulo":"Critical coupling to Tamm plasmons","resumen":"The conditions of critical coupling of light to Tamm plasmons are investigated with  comprehensive numerical simulations, highlighting the parameters that maximize absorption of  incident light in the metal layer. The asymmetric response in reflection and absorption with  respect to the direction of incidence is discussed, the two cases yielding different optimal  coupling conditions. These findings are relevant for the design of optimized Tamm structures,  particularly in applications such as narrow-band thermal emitters, field-enhanced spectroscopy  and refractive-index sensing.","palabras_clave":"Tamm plasmons|photonic crystals|critical coupling"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19009,"idioma_id":4,"titulo":"Neuroanatomical and Functional Characterization of CRF Neurons of the Amygdala using a Novel Transgenic Mouse Model","resumen":"The corticotropin-releasing factor (CRF)-producing neurons of the amygdala have been implicated in behavioral and physiological responses associated with fear, anxiety, stress, food intake and reward. To overcome the difficulties in identifying CRF neurons within the amygdala, a novel transgenic mouse line, in which the humanized recombinant Renilla reniformis green fluorescent protein (hrGFP) is under the control of the CRF promoter (CRF-hrGFP mice), was developed. First, the CRF-hrGFP mouse model was validated and the localization of CRF neurons within the amygdala was systematically mapped. Amygdalar hrGFP-expressing neurons were located primarily in the interstitial nucleus of the posterior limb of the anterior commissure, but also present in the central amygdala. Secondly, the marker of neuronal activation c-Fos was used to explore the response of amygdalar CRF neurons in CRF-hrGFP mice under different experimental paradigms. C-Fos induction was observed in CRF neurons of CRF-hrGFP mice exposed to an acute social defeat stress event, a fasting\/refeeding paradigm or lipopolysaccharide (LPS) administration. In contrast, no c-Fos induction was detected in CRF neurons of CRF-hrGFP mice exposed to restraint stress, forced swimming test, 48-h fasting, acute high-fat diet (HFD) consumption, intermittent HFD consumption, ad libitum HFD consumption, HFD withdrawal, conditioned HFD aversion, ghrelin administration or melanocortin 4 receptor agonist administration. Thus, this study fully characterizes the distribution of amygdala CRF neurons in mice and suggests that they are involved in some, but not all, stress or food intake-related behaviors recruiting the amygdala.","palabras_clave":"CRF|AMYGDALA|NEURONS|MICE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19010,"idioma_id":4,"titulo":"Ghrelin's orexigenic effect is modulated via a serotonin 2C receptor interaction","resumen":"Understanding the intricate pathways modulating appetite and subsequent   food intake is of particular importance considering the rise in obesity   incidence across the globe. The serotonergic system, specifically the   5-HT2C receptor, has shown to be of critical importance in the   regulation of appetite and satiety. The GHS-R1a receptor is another key   receptor well-known for its role in the homeostatic control of food   intake and energy balance. We recently showed compelling evidence for an   interaction between the GHS-R1a receptor and the 5-HT2C receptor in an   in vitro cell line system heterologously expressing both receptors.   Here, we investigated this interaction further. First, we show that the   GHS-R1a\/5-HT2C dimer-induced attenuation of calcium signalling is not   due to coupling to G&#945;S, as no increase in cAMP signalling is observed.   Next, flowcytometry fluorescence resonance energy transfer (fcFRET) is   used to further demonstrate the direct interaction between the GHS-R1a   receptor and 5-HT2C receptor. In addition, we demonstrate co-localized   expression of the 5-HT2C and GHS-R1a receptor in cultured primary   hypothalamic- and hippocampal rat neurons, supporting the biological   relevance of a physiological interaction. Furthermore, we demonstrate   that when 5-HT2C receptor signalling is blocked, ghrelin?s orexigenic   effect is potentiated in vivo. In contrast, the specific 5-HT2C receptor   agonist lorcaserin, recently approved for the treatment of obesity,   attenuates ghrelin-induced food intake. This underscores the biological   significance of our in vitro findings of 5-HT2C receptor-mediated   attenuation of GHS-R1a receptor activity. Together, this study   demonstrates, for the first time, that the GHS-R1a\/5-HT2C receptor   interaction translates into biological significant modulation of   ghrelin?s orexigenic effect. This data highlights the potential   development of a combined GHS-R1a and 5-HT2C receptor treatment strategy   in weight management.","palabras_clave":"GHRELIN|GROWTH HORMONE SECRETAGOGUE RECEPTOR|SEROTONIN 2C RECEPTOR|LORCASERIN|FOOD INTAKE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19011,"idioma_id":4,"titulo":"Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom","resumen":"The nervous and endocrine systems act together to regulate all physiological processes essential for the body homeostasis control. Given the strict communication restrictions that the brain-blood barrier (BBB) imposes, the interplay between these two systems requires a variety of delicate anatomical interfaces and physiological mechanisms that guarantee the precise function of the neuroendocrine system as a whole. The study of the mechanisms by which hormones act in the brain in order to&nbsp; regulate specific neuronal populations is a research topic rather neglected. Our group studies the neuronal circuitries and molecular mechanisms by which the stomach produced hormone ghrelin regulates appetite and other physiological functions. A clear notion of the brain targets of peripheral ghrelin is essential for the comprehensive understanding of the physiological role of this hormone. Ghrelin is called ?the hunger hormone? since it is the only known orexigenic peptide hormone. The target for ghrelin orexigenic actions is the brain, which contains a variety of ghrelin-responsive nuclei; however, several evidences suggest that the accessibility of peripheral ghrelin to the brain is strikingly low. Here, we briefly summarize the current knowledge in this topic and discuss this intriguing neuroendocrinological issue.","palabras_clave":"FOOD INTAKE|APPETITE|BRAIN ACCESSIBILITY|ARCUATE NUCLEUS|HYPOTHALAMUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19012,"idioma_id":4,"titulo":"Solving a Big- Data Problem with GPU: The Network Traffic Analysis.","resumen":"The number of devices connected to the Internet has increased significantly and will grow exponentially in the near future, it is due to the lower costs. It is expected that next years, data traffic via Internet increases up to values around zettabyte. As a consequence of this increase, it can be observed that the data traffic is growing faster than the capacity of their processing.In recent years, the identification of Internet traffic generated by different applications has become one of the major challenges for telecommunications networks. This characterization is based on understanding the composition and dynamics of Internet traffic to improve network performance.To analyse a huge amount of data generated by networks traffic in real time requires more power and capacity computing. A good option is to apply High Performance Computing techniques in this problem, especifically use Graphics Processing Unit (GPU). Its main characteristics are high computational power, constant development and low cost, besides provides a kit of programming called CUDA. It offers a GPUCPU interface, thread synchronization, data types, among others.In this paper we present the causes of increasing data volumes circulating on the network, data analysis and monitoring current techniques, and the feasibility of combining data mining techniques with GPU to solve this problem and speed up turnaroundtimes.","palabras_clave":"Big Data|GPGPU|Network Traffic|Analyzing Information"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19013,"idioma_id":5,"titulo":"ACTIVIDADES PROPUESTAS EN CURSOS BÁSICOS DE QUÍMICA: ¿QUÉ HABILIDADES COGNITIVO LINGÜÍSTICAS PROMUEVEN?","resumen":"En este trabajo se analizan las actividades de la guía de estudio deun curso básico de química universitaria para determinar las habilidades cognitivo lingüísticas que promueven. Se compara este análisis con el realizado previamente sobre actividades propuestas en evaluaciones escritas. Se utiliza una caracterización que, respondiendo a un criterio didáctico, diferencia entre actividades con énfasis en: 1) memorización de información y cálculo y 2) manejo significativo de teorías y conceptos. Ambas requieren la movilización de las habilidades cognitivo lingüísticas: definir, describir y justificar, en diferente grado. Las decategoría 1, se relacionan más con definir y describir. Las   Correspondientes a la 2 favorecerían el desarrollo de la habilidad de justificar. Los resultados muestran que las características de las actividades de la guía de estudio no se corresponden con la promoción de la habilidad de justificar, que es la más valorada según los objetivos de aprendizaje implícitos en las evaluaciones escritas.","palabras_clave":"ACTIVIDADES|QUÍMICA|HABILIDADES COGNITIVOLINGÜISTICAS|UNIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19014,"idioma_id":4,"titulo":"Comparison of Imazalil Removal onto Montmorillonite and Nanomontmorillonite and Adsorption Surface Sites Involved: An Approach for Agricultural Wastewater Treatment","resumen":"To remove fungicide Imazalil (IMZ) (commercial formulation) from agricultural wastewater, adsorption was  performed and compared among montmorillonite (Mt) and four organo-Mts (OMts), with different octadecyltrimethylammonium  (ODTMA) loadings. The agglomerates size increase of OMts with respect to Mt found encourages the use of the former in  agricultural wastewater treatment. Characterization of the OMts adsorbents by powder X-ray diffraction, infrared spectroscopy,  and thermogravimetric analyses, indicated that ODTMA was present in the interlayer with different molecular arrangements, a  diminution of the thermal stability of the OMts and an increase of ODTMA loading being observed at the same time. Zeta  potential measurements showed electric surface charge reversion from negative to positive when the surfactant loading exceeded  100% of the clay cation exchange capacity (CEC). The IMZ adsorption on the raw Mt showed high pH dependence and affinity  toward the fungicide, while OMts showed best IMZ adsorption capacity at high IMZ concentrations inversely related with the  ODTMA loading. The characterization of IMZ&#8722;adsorbed samples indicated that for IMZ&#8722;Mt the interaction between IMZH+  and the siloxane surface was electrostatic. For IMZ&#8722;OMt samples the presence of new XRD and FTIR peaks suggested different  IMZ interlayer arrangements and direct interaction with the surface, respectively. Analysis of zeta potential measurements  indicated synergetic effects between the ODTMA and IMZ molecules at the external surface.","palabras_clave":"Montmorillonite|Imazalil|Adsorption"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19015,"idioma_id":4,"titulo":"The activity of propolis in the scavenging of Vitamin B2-photogenerated ROS","resumen":"Se adjunta Resumen en .pdf","palabras_clave":"PROPOLIS|VITAMIN B2 PHOTOGENERATE|ANTIOXIDANT|PHOTODEGRAGATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19016,"idioma_id":4,"titulo":"Lindane remov al using Streptomyces strains and maize plants: a biological system for reducing pesticides in soils","resumen":"Background and AimsPlants and contaminant-degrading microbes are a suitable combination for theremediation of pesticides. The aim of this study was to evaluate the effectiveness ofStreptomyces strains cultured with maize plants in relation to lindane removal.MethodsFour Streptomyces strains were cultured and added as both single and mixed cultures,along with maize plants, to artificially polluted hydroponic systems and soils. Theeffectiveness of the resulting soil bioremediation was then evaluated throughphytotoxicity testing using lettuce seedlings.ResultsIn the hydroponic and soil experiments, similar levels of lindane removal were recordedin the inoculated and non-inoculated systems where maize plants were introduced.However, the vigor index (VI) of the maize plants was highest when grown ininoculated and artificially polluted soil. In the phytotoxicity assay, the VI of the lettuceseedlings increased with increasing bioremediation time for the soils, thus indicatingthe effectiveness of the process.ConclusionsSimilar levels of lindane removal were recorded in both inoculated and non-inoculatedplanted systems, indicating that pesticide removal was not significantly affected by thebacterial inoculant. However, inoculation an actinobacteria consortium led to anincrease in the VI of the maize and protected the plants against the existing toxicity.Furthermore, maize plants may attenuate the transient toxic effects of microbial lindanedegradation.","palabras_clave":"LINDANE|STREPTOMYCES STRAINS|MAIZE PLANTS|PHYTOREMEDIATION|PHYTOTOXICITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19017,"idioma_id":4,"titulo":"Self-Organizing Maps for Imputation of Missing Data in Incomplete Data Matrices","resumen":"The problem of incomplete data matrices is repeatedly found in large databases, posing a significant obstacle for an effective treatment of data. This paper examines a self-organizing-map (SOM) based method of data imputation under the concept of distance object per one weight, to predict physicochemical parameters ofwater samples in a data setwhere concentrations of different analyteswere missed. The methodwas evaluated according to two different possibilities: (a) including vectors of sampleswith andwithoutmissing data in the training data set and (b) pre-training a SOM for a data set with no missing values and then making imputations for a second data set (prediction set) of samples with missing values. Evaluations were made using a surface water data set of 270samples from Reconquista River, in Buenos Aires Province, Argentina, by artificially setting a range of 17% to 39% of the data to missing. Results were compared to imputations made through professional criteria. SOMs gave reasonable estimates, with no statistically significant differences fromestimates made through professional criteria, proving thus to be a suitable time-saving imputation method.","palabras_clave":"Chemometrics|Artificial neural network|Missing data imputation|Environmental data set"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19018,"idioma_id":4,"titulo":"Comparison between Principal Component Analysis and Wavelet Transform 'Filtering Methods for Lightning Stroke Classification on Transmission Lines","resumen":"This paper presents an assessment between Principal Component Analysis (PCA) and Wavelet Transform (WT) signal processing techniques applied for Transmission Lines (TLs) lightning stroke classification. In this work, the atmospherics discharges signals are analyzed in two steps. The first step objective is patterns extraction, which is developed through Principal Component Analysis and the Wavelet Transform. The second step objective is pattern classification, which is developed using three different techniques: Artificial Neural Network (ANN), k-Nearest Neighbors (k-NN) and Support Vector Machine (SVM).  This work presents as assessment of lightning stroke classification, providing useful information, especially in extraction and selection of mother functions and the use of PCA. Both methodologies are assessed under different lightning stroke conditions. Features as extraction, speed, orthogonal functions and others are comparatively assess.  Resu lts show that by using PCA, optimal mother functions can be extracted, presenting a new alternative for relaying protection.","palabras_clave":"Orthogonal functions|Lightning disturbances|Comparative evaluation|Filters"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19019,"idioma_id":4,"titulo":"Evaluation of the content of phenolic compounds and antioxidant activity of wines. Effect of malolactic fermentation","resumen":"EVALUATION OF THE CONTENT OF PHENOLIC COMPOUNDS AND ANTIOXIDANT ACTIVITY OF WINES. EFFECT OF MALOLACTIC FERMENTATION. Saguir, F.M., Rivero, L.V., Maturano, C. y Rodríguez Vaquero, M.J. Facultad de Bioquímica, Química y Farmacia. Universidad Nacional de Tucumán. Ayacucho 471. Tucumán, Argentina. fabianasaguir@fbqf.unt.edu.ar Red wine is a source of phenolic compounds which are recognized by their antioxidant properties and their probable role in the prevention of various diseases associated with oxidative stress. Malolactic fermentation (MLF) conducted by lactic acid bacteria can produce changes in its composition. In this study we investigated the changes in the content of phenolic compounds and antioxidant activity of red wine Malbec variety, obtained by micrvinification after MLF induced by Oenococus oeni MS46 isolated from fermented must of our region. At the same time, we compared the results obtained with commercial red wines made from grapes of the same variety. The phenolic compounds, expressed as mg\/l of equivalent of Gallic acid (GAE) were determined by the Folin-Ciocalteu method and the antioxidant capacity by measuring the reducing activity of ferric iron (FRAP) and capture of free radicals 2, 2-diphenyl-1-picrilhidracilo (DPPH) and 2,2-azino-di-3-etilbenzotiazolin sulfonic acid (ABTS). At the end of MLF the MS46 strain grew 1.58 logarithmic units and L-malic acid (2 g\/l) was completely consumed. At this time the total phenolic compounds content (2670 mgGAE\/ml) increased 15% compared with the alcoholic fermentation end and it was similar to the concentrations found in the commercial wines. In all cases the flavonoid fraction was majority. FRAP, DPPH, ABTS methods showed that, in general, the wine obtained by microvinification had the highest antioxidant activity, which was superior than that obtained in commercial wines (among 15 and 25%). In conclusion, the FML induced by the MS46 strain increased the content of phenolic compounds which was related to its higher antioxidant activity, representing this property a benefit to the health of the consumer.","palabras_clave":"Oenococcus oeni, phenolics compounds , wine, malolactic fermentation."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19020,"idioma_id":4,"titulo":"Estimation of the Particle Size Distribution of Colloids from Multiangle Dynamic Light Scattering Measurements with Particle Swarm Optimization","resumen":"In this paper particle Swarm Optimization (PSO) algorithms are applied to estimate the particle size distribution (PSD) of a colloidal system from the average PSD diameters, which are measured by multi-angle dynamic light scattering. The system is considered a nonlinear inverse problem, and for this reason the estimation procedure requires a Tikhonov regularization method. The inverse problem is solved through several PSO strategies. The evaluated PSOs are tested through three simulated examples corresponding to polysty-rene (PS) latexes with different PSDs, and two experimental examples obtained by simply mixing 2 PS standards. In general, the evalu-ation results of the PSOs are excellent; and particularly, the PSO with the Trelea?s parameter set shows a better performance than other implemented PSOs.","palabras_clave":"PSD|NANOPARTICLES|LIGHT SCATTERING|PSO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19021,"idioma_id":5,"titulo":"El Laboratorio Virtual como Estrategia para la Enseñanza -Aprendizaje del Concepto de Mol","resumen":"xx","palabras_clave":"laboratorio virtual |mol|química"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19022,"idioma_id":5,"titulo":"Procesos socioculturales y educación en equidad de género. Entre las marcas de género y los debates por la justicia en el mundo escolar","resumen":"Título: Procesos socioculturales y educación en equidad de género. Entre las marcas de género y los debates por la justicia en el mundo escolar   Autoras: Ferrucci Susana; Bocco Graciela C.; Buffa Silvina; Castro Marcela A.y Gómez, Ma.Marta  Título abreviado: Procesos socioculturales y educación en equidad de género.  Fecha de envío del manuscrito: 31 de mayo de 2013  Grupo de investigación al que pertenece el trabajo: Antropología y Género   Correos electrónicos de las autoras: ferruccisusana@gmail.com gcbocco@hotmail.com; silbuffa@gmail.com; marcelacastro05@hotmail.com;  mariamgomez40@hotmail.com   Fecha de finalización de la redacción del trabajo: 31 de mayo de 2013  Filiación académica de las autoras: Cátedra Antropología Cultural Contemporánea y Latinoamericana. Facultad de Psicología. UNC.    Resumen  Los desarrollos de la teoría social y de género destacan la estrecha relación del género con el poder y la violencia. Por eso, para producir las transformaciones tendientes a lograr un orden de género que no refuerce la jerarquía de lo masculino y la heterosexualidad es indispensable el papel de las instituciones y organizaciones sociales para avanzar en el camino a la equidad entre géneros. Este trabajo analiza acciones, argumentos y significados  asociados a la educación en equidad de género que sustentan docentes y autoridades de instituciones educativas de diferentes niveles y modalidades de gestión. Por ?educación en equidad de género? entendemos al proceso educativo integral que incorpora la perspectiva de género en la educación orientada a reducir y eliminar las inequidades entre géneros.  El estudio se realizó con metodología cualitativa mediante la realización de entrevistas y observación participante. Las conclusiones del trabajo muestran que la educación en equidad de género es aún una dimensión incipiente entre autoridades y docentes. Los puntos más aceptados refieren a una parcial igualdad de trato entre varones y mujeres heterosexuales; la diversidad sexual, en cambio, es aceptada desde lo discursivo aunque genera incertidumbre, temor o rechazo. No obstante, la normativa jurídica orientada hacia una educación en equidad de género posibilita nuevas construcciones de género que promuevan vidas libres de violencia para los grupos mencionados.  Palabras clave: Género, equidad, educación.    Abstract  Socio-cultural processes and education in gender equality    Abstract    Advances in social and gender theory stress the close relationship of gender with power and violence. Hence, to produce the necessary transformations tending to achieve a gender order that does not rely on masculine hierarchy and heterosexuality, the role of institutions and social organization, among other factors, is essential to make progress on the way to gender equality. This work analyzes actions, arguments and meanings associated with education from a gender equality perspective held by educators and authorities of education institutions of different levels and administration modes. By ?education from a gender equality perspective? we understand the integrative educational process that incorporates gender perspective in student education aimed at reducing and eradicating gender inequalities. The study was conducted using a qualitative methodology, borrowing from the contributions of the ethnographic method regarding interviews and participant observation. The conclusions of our work show that education from a gender equality perspective is still an incipient dimension among authorities and professors of educational institutions. The most widely accepted issues are those referring to a partial equality in treatment between heterosexual men and women; sexual diversity, however, is accepted at a discursive level although it generates uncertainty, fear or rejection. Nevertheless, the legal framework oriented to gender equality education acts an engine generating new gender constructions that promote violence-free and fair lives.         Key words: Gender- Equality- Education","palabras_clave":"Género|Equidad|Educación"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19023,"idioma_id":4,"titulo":"Valley properties of doped graphene in a magnetic field","resumen":"The aim of this work is to describe the electronic properties of graphene in a constant magnetic field in the long wavelength approximation with random binary disorder, by solving the Soven equation self-consistently. Density of state contributions for different valleys in each sublattice sites are obtained for different values of magnetic field strength showing remarkable differences between K and K? valleys. A band gap is obtained by an asymmetric on-site impurity concentration and the graphene electrons acquire an anomalous magnetic moment, which is opposite in different valleys, which depend highly in the interplay between the impurity band, the band edges and the broadening of the Landau levels. In turn, magnetization as a function of B for different on-site random impurities is computed showing that by decreasing the on-site impurity energy values, maximum magnetization is shifted towards higher values of B which can be used to create and manipulate polarized valley currents. Finally, conductivity and local vertex function are obtained as a function of energy showing that scattering contributions from A and B sublattices differ significantly. Effective medium local two-irreducible vertex is computed showing that scattering from sublattices A and B do not contribute equally, which can be related to weak antilocalization. From these results, it could be possible to explore how the valley pseudospin can be used to create polarized currents by populating asymmetrically the sublattice sites, where the population can be tuned with the applied magnetic field strength.","palabras_clave":"GRAPHENE|MAGNETIC FIELD|ELECTRONIC PROPERTIES|LONG WAVELENGTH APPROXIMATION|SOVEN EQUATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19024,"idioma_id":4,"titulo":"Chlorogenic acid biosynthesis appears linked with suberin production in potato tuber (Solanum tuberosum)","resumen":"Potato (Solanum tuberosum L.) is a good source of dietary antioxidants. Chlorogenic acid (CGA) and caffeic acid (CA) are the most abundant phenolic acid antioxidants in potato and formed by the phenylpropanoid pathway. A number of CGA biosynthetic routes that involve hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase (HQT) and\/or hydroxycinnamoyl-CoA shikimate\/quinate hydroxycinnamoyl transferase (HCT) have been proposed but little is known in potato. CA production requires a caffeoyl shikimate esterase (CSE) and serves as substrate of lignin precursor ferulic acid, via the action of caffeic\/5-hydroxyferulic acid O-methyltransferase (COMT I). CGA is precursor of caffeoyl-CoA and, via caffeoyl-CoA O-methyltransferase (CCoAOMT), of feruloyl-CoA. Feruloyl-CoA is required for lignin and suberin biosynthesis, crucial for tuber development. Here, metabolite and transcript levels of mentioned and related enzymes, such as cinnamate 4-hydroxylase (C4H), were determined in flesh and skin of fresh and stored tubers. Metabolite and transcript levels were higher in skin than in flesh, irrespective of storage. CGA and CA production appear to occur via p-coumaroyl-CoA, using HQT and CSE, respectively. HCT is likely involved in CGA remobilization towards suberin. The strong correlation between CGA and CA, the correspondence with C4H, HQT, CCoAOMT2 and CSE, and the negative correlation of HCT and COMT I in potato tubers, suggest a major flux towards suberin.","palabras_clave":"ANTIOXIDANT|CAFFEIC ACID|FLAVONOID METABOLISM|PHENOLICS ACID METABOLISM|SOLANUM TUBEROSUM|STORAGE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19025,"idioma_id":4,"titulo":"Polycyclic aromatic hydrocarbons (PAHs) survey on tea (Camellia sinensis) commercialized in Argentina","resumen":"Polycyclic aromatic hydrocarbons (PAHs) occurrence in fifty-four samples   of tea marketed in the main supermarkets from Argentina was described   for the first time. A high performance liquid chromatography (HPLC)   method was applied with fluorescence detector (FLD) and UV-VIS diodes   array detector (DAD) for the analysis of sixteen PAHs in tea (camellia sinensis),   with percentages recoveries higher than 84.5%. Contamination expressed   as the sum of sixteen analysed PAHs was between 509.7 and 2746.5&nbsp;&#956;g&nbsp;kg&#8722;1 on dry mass and the mean was 930.4&nbsp;&#956;g&nbsp;kg&#8722;1 on dry mass.","palabras_clave":"Polycyclic aromatic hydrocarbons|Tea| Camellia sinensis|Benzopyrene"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19026,"idioma_id":4,"titulo":"Efficiency and stability in subtropical beef cattle grazing systems in the northwest of Argentina","resumen":"The objective of this work was to evaluate the efficiency and stability of cow-calf, fattening and whole cycle beef cattle agro-ecosystems from the subtropical region of Argentina. For this purpose, an agro-ecosystem model consisting of a production and a management system was developed. Flexible management rules were incorporated. This simulation-based study compare potential trends of different agro-ecosystems under different animal body sizes and several management options traditionally applied in the region. The experiment aimed at estimating productive, energetic and economic efficiency and stability. The results showed that whole cycle and cow-calf systems were more stable but less productive than fattening systems. Within each agro-ecosystem, as body size increased, energetic and economic efficiency and stability decreased. Systems dynamics and multi-criteria approaches allowed recognizing tradeoffs among indicators, and main differences between agro-ecosystems. Further investigation is required to generalize these findings to other system structures, particularly when economic aspects are taken into account in decision making processes.","palabras_clave":"EFFICIENCY|STABILITY|FRAME SIZE|SYSTEM DYNAMICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19027,"idioma_id":4,"titulo":"Antibacterial activity of extracts and compounds isolated from the Andean medicinal plant Azorella cryptantha (Clos) Reiche, Apiaceae","resumen":"tAzorella cryptantha (Clos) Reiche, Apiaceae, vernacular name ?yerba del soldado or cuerno de cabra?is a medicinal herb that grows in the Andean mountains (Argentina). An infusion or decoction of theleaves is employed as cholagogue and digestive, usually to treat food-borne illnesses associated withenterobacteria. Extracts and compounds from two Argentinean populations were subjected to antibac-terial assays against pathogenic bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidisand Yersinia enterocolitica) and Gram (+) Staphylococcus aureus methicillin-sensitive and methicillin-resistant microorganisms. The antibacterial activity-guided fractionation against a panel of ATCC andclinically isolated bacteria was done according to CLSI protocols. The petroleum ether extracts fromboth populations showed strong antibacterial activity against S. enteritidis with MIC values from 125to 250 g\/ml, and also towards methicillin-sensitive Staphylococcus aureus, and Gram negative strainsE. coli, P. aeruginosa, Salmonella sp. and Yersinia enterocolítica-PI, (MICs between 400 and 1000 g\/ml).Fractions from the petroleum extracts showed strong antimicrobial activity, against Escherichia coliATCC 25922, E. coli-LM1, E. coli-LM2, and Salmonella enteritidis-MI, with MICs values between 31.2 and125 g\/ml. The bioassay-guided fractionation of the petroleum ether extracts led to the isolation ofnine terpenes: azorellolide (1), mulinol (2), stachytriol (3),1,10,4,5-diepoxy-7-germacran-6-ol(4), 1,10,4,5-diepoxy-7-germacran-6-ol (5), 1,2,3,3,4,5,6,7,8,8-decahydro-7-(1-hydroxy-1-methylethyl)-1,4-dimethylazulene-3,8-diol (6), madreporanone (7), yaretol (8) and chrysotol or6,10-epoxy-4-hydroxyguaiane (9). Compounds 3, 5, 6 and 9 are reported here for the first timefrom A. cryptantha. Their structures and relative configurations have been determinated by means 1Dand 2D NMR techniques. Chrysothol (9), madreporanone (7), and stachytriol (3) showed strong antimi-crobial activities (MICs = 50?100 g\/ml) against enterobacteria E. coli and S. enteritidis. The antibacterialactivity found for some of the isolated compounds supports least in part, the commercial exploited ofthis species to treat food-borne illnesses associated with Gram negative pathogenic bacteria.","palabras_clave":"AZORELLA CRYPTANTHA|ANTIBACTERIAL ACTIVITY|CHRYSOTHOL|MADREPORANONE|STACHYTRIOL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19028,"idioma_id":4,"titulo":"The E. coli Thioredoxin Folding Mechanism: The Key Role of the C-terminal Helix","resumen":"In this work, the unfolding mechanism of oxidized Escherichia Coli thioredoxin (EcTRX) was investigated experimentally and computationally. We characterized seven point mutants distributed along the C-terminal &#945;-helix (CTH) and the preceding loop. The mutations destabilized the protein against global unfolding while leaving the native structure unchanged. Global analysis of the unfolding kinetics of all variants revealed a linear unfolding route with a high-energy on-pathway intermediate state flanked by two transition state ensembles TSE1 and TSE2. The experiments show that CTH is mainly unfolded in TSE1 and the intermediate and becomes structured in TSE2. Structure-based molecular dynamics are in agreement with these experiments and provide protein-wide structural information on transient states. In our model, EcTRX folding starts with structure formation in the &#946;-sheet, while the protein helices coalesce later. As a whole, our results indicate that the CTH is a critical module in the folding process, restraining a heterogeneous intermediate ensemble into a biologically active native state and providing the native protein with thermodynamic and kinetic stability.","palabras_clave":"PROTEIN STRUCTURE|THIOREDOXIN|PROTEIN FOLDING|MOLECULAR DYNAMICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19029,"idioma_id":4,"titulo":"Physiological, structural and molecular traits activated in strawberry plants after inoculation with the plant growth promoting bacterium Azospirillum brasilense REC3","resumen":"The plant growth-promoting strain REC3 of Azospirillum brasilense, isolated fromstrawberry roots, prompts growth promotion and systemic protection againstanthracnose disease in this crop. Hence, we hypothesised that A. brasilense REC3 caninduce different physiological, structural and molecular responses in strawberryplants. Therefore, the aim of this work was to study these traits activated in Azospirillum-colonised strawberry plants, which have not been assessed until now. Healthy,in vitro micropropagated plants were root-inoculated with REC3 under hydroponicconditions; root and leaf tissues were sampled at different times, and oxidative burst,phenolic compound content, malondialdehyde (MDA) concentration, callose deposition,cell wall fortification and gene expression were evaluated. Azospirillum inoculationenhanced levels of soluble phenolic compounds after 12 h post-inoculation (hpi),while amounts of cell wall bound phenolics were similar in inoculated and controlplants. Other early responses activated by REC3 (at 24 hpi) were a decline of lipid peroxidationand up-regulation of strawberry genes involved in defence (FaPR1), bacterialrecognition (FaFLS2) and H2O2 depuration (FaCAT and FaAPXc). The last mayexplain the apparent absence of oxidative burst in leaves after bacterial inoculation.Also, REC3 inoculation induced delayed structural responses such as callose depositionand cell wall fortification (at 72 hpi). Results showed that A. brasilense REC3 iscapable of exerting beneficial effects on strawberry plants, reinforcing their physiologicaland cellular characteristics, which in turns contribute to improve plantperformance.","palabras_clave":"Azospirillum brasilense|Fragaria ananassa|Callose|Wall fortification"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19030,"idioma_id":4,"titulo":"Factors Affecting Fruit Quality in Strawberries Grown in a Subtropical Environment","resumen":"Variations of strawberry fruit quality due to year, harvest date,  cultivar, and nutrition were studied in Tucumán, Argentina.  ?Camarosa?, ?Camino Real?, ?Candonga?, and ?Ventana? were fertilized  with ?C? (control; 120 kg N\/ha, 70 kg P2O5\/ha, 220 kg  K2O\/ha, 40 kg CaO\/ha, and 20 kg MgO\/ha) and ?1.5C? in 2006,  ?C?, ?1.33C?, and ?1.66C? in 2007, and ?C?, ?1.5C?, and ?2C?  in 2008, without affecting fruit quality. Fruit weight decreased  with temperature and crop load. Firmness decreased with rainfall  and temperature. Redness increased with temperature and  decreased with rainfall. Soluble solids content decreased with crop  load. Titratable acidity increased with temperature.","palabras_clave":"FRUIT WEIGHT|FIRMNESS|SKIN COLOR|SOLUBLE SOLIDS CONTENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19031,"idioma_id":4,"titulo":"Variation of Creep resistance in Ferritic Steels by a Heat Treatment","resumen":"In the power plants, boiler pipes and heaters, made of ferritic steels low creep resistant alloy used. These steels have a microstructure with fine stable alloy carbides that impede the movement of the dislocations, however it is inevitable that during long periods of service or very critical conditions, microstructural changes occur that are responsible for the loss of material strength. In the past decades the 1Cr0.5Mo steel was used, but it has been replaced by ferritc steels containing higher amounts of Cr and Mo, with the addition of other micro alloying elements such as niobium, titanium and vanadium to increase their mechanical strength.The objective of this work is to study the creep behavior of 1Cr 0.5Mo steel and to compare its strength when prior to service it is subjected to different heat treatments that improve its conditions of service, as that is beneficial from the economical point of view. Tensile creep tests are performed at a temperature range between 843 and 893 K, and applied stresses between 131 and 205 MPa in the material reception conditions comparing its behavior with other that previously has undergone different heat treatments. From experimental data the characteristic parameters are calculated such as the creep coefficient of stress and activation energy.The microstructural variation of the original material is also analyzed, after heat treatment and creep samples were characterized by optical microscopy, scanning electron microscopy (SEM) and analysis by dispersive X- ray spectroscopy (EDX), to evaluate the effects of kinetics changes occurred in the precipitated phases and the presence of microstructural damage, such as nucleation, growth and coalescence of micro cavities. The microhardness of the phases present in the different samples are also measured.","palabras_clave":"1 Cr - 0,5Mo steels|Microestructure|Creep|Characteristics parameter"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19032,"idioma_id":4,"titulo":"Quantitative trait loci (QTL) identification for resistance to Mal de Rio Cuarto virus (MRCV) in maize based on segregate population","resumen":"xxx","palabras_clave":"Zea mays L. |Quantitative trait locus (QTL)|segregant population |Mal de Río Cuarto virus (MRCV)"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19033,"idioma_id":4,"titulo":"Tl2C2O4.H2C2O4, a new crystalline form of thallium(I) oxalate","resumen":"&nbsp;&nbsp;&nbsp;&nbsp; The title compound was prepared byreaction, in aqueous solution, of Tl2CO3 and H2C2O4×2H2O in a 1:2 molar ratio. Its crystal structure was solvedby X-ray diffraction methods. It crystallizes in the monoclinic space group P21\/awith Z = 2 molecules per unit cell. The oxalic acid molecule and theoxalate anion are planar, at crystallographic inversion centers, and linked toeach other by strong OH.....O hydrogen bondsgiving rise to a polymeric structure. The Tl(I) ion is in a distortedpolyhedral coordination with nine neighboring O-atoms, five of oxalate anionsand four others of oxalic acid molecules. The FTIR and FT-Raman spectra of thecompound were also recorded and are briefly discussed.","palabras_clave":"Crystal structure|FTIR spectra|FT-Raman spectra|Synthesis|Thallium(I)oxalate-oxalic acid"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19034,"idioma_id":4,"titulo":"Quaternary refugia and secondary contact in the southern boundary of the Brazilian subregion: comparative phylogeography of freshwater fish","resumen":"Freshwater fish are an ideal model to illustrate how climate-tectonic changes affect the distribution of genetic variation. Freshwater bodiesare extensively affected by environmental changes, with streams even changing their courses in the most extreme cases. Fortunately,this situation is reflected in the genetic composition of populations and may currently be inferred from the study of mitochondrial DNAmolecular markers. Here we analyze and compare the phylogeographic patterns of the species Corydoras paleatus and Jenynsia multidentataat the southern limit of the Brazilian subregion. These basins are isolated in the current hydrogeographic pattern due to geologic andpaleoclimatic changes. Our results support a concurrent pattern for both species. Some lineages have persisted in the area under adverseclimate conditions, possibly in environmental refuges, while other lineages may have colonized the area later by means of paleodrainagesconnections. In addition, the presence of independent, greatly diverging lineages, even within the same watercourses, suggests secondarycontact between these lineages. This work represents a first approach to understand how geologic and paleoclimatic changes have affectedthe distribution of genetic variation in the Southern Pampean Area.Key words","palabras_clave":"filogeografia|peces|Subregion Brasilica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19035,"idioma_id":4,"titulo":"Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation","resumen":"Stress in pregnant rats caused by chronic immobilization alters the pattern of secretion of corticosterone and modifi es the hypothalamic-pituitary-adrenal axis (HPA) of the fetus. Early postnatal handling, however, may reverse the effects of increased secretion of corticosterone. We investigated the effects of prenatal stress and postnatal handling on the activity of the HPA axis of male offspring of stressed female rats. Male 90-day-old rats from four groups were investigated: prenatally stressed animals without postnatal handling, prenatally stressed animals with postnatal handling, unstressed control animals with postnatal handling, and unstressed control animals without postnatal handling. After sacrifi ce, the adrenal glands were weighed to determine the adrenal-somatic index. Apoptosis was evaluated by TUNEL assay and active caspase 3 expression. We found that the adrenal gland cortex:medulla ratio increased in animals with prenatal stress and that eventually the stress caused apoptosis. Handling newborns to simulate maternal activity ameliorated the some of the negative effects of prenatal stress.","palabras_clave":"Adrenal gland|Apoptosis|Handling|Hypothalamic-pituitary-adrenal axis|Immobilization|Prenatal stress|Rats"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19036,"idioma_id":4,"titulo":"An RVE-based multiscale theory of solids with micro-scale inertia and body force effects","resumen":"Ver listado de trabajos completos en Latteshttp:\/\/lattes.cnpq.br\/2207239537360072           Web of Science  Total de trabalhos:20  Total de citações:261  Fator H:9  Blanco, Pablo J&nbsp;&nbsp;Data:&nbsp;22\/04\/2015           SCOPUS  Total de trabalhos:37  Total de citações:345  Blanco, P.J.&nbsp;&nbsp;Data:&nbsp;22\/04\/2015A multiscale theory of solids based on the concept of representative   volume element (RVE) and accounting for micro-scale inertia and body   forces is proposed. A simple extension of the classical Hill?Mandel   Principle together with suitable kinematical constraints on the   micro-scale displacements provide the variational framework within which   the theory is devised. In this context, the micro-scale equilibrium   equation and the homogenisation relations among the relevant macro- and   micro-scale quantities are rigorously derived by means of   straightforward variational arguments. In particular, it is shown that   only the fluctuations of micro-scale inertia and body forces about their   RVE volume averages may affect the micro-scale equilibrium problem and   the resulting homogenised stress. The volume average themselves are   mechanically relevant only to the macro-scale.","palabras_clave":"Multiescala|Inertia; Body forces; RVE; |Hill?Mandel Principle|Homogenisation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19037,"idioma_id":4,"titulo":"Mechanical response of fiber reinforced concrete overlays over asphalt concrete substrate: Experimental results and numerical simulation","resumen":"Fiber reinforced concrete overlays are nowadays an alternative for repairing and reinforcing pavements. The contribution of concrete overlays strongly depends on the bond with the substrate. The fibers help sewing contraction joints and eventual cracks and, in this way prevent the propagation of cracks along the substrate overlay interface. Therefore, the addition of fibers to the overlay allows reducing repair thickness, increasing service life and improving pavements general performance. Some experimental tests performed for the development of a method to assess different fibers efficiency in this type of applications are presented in this paper. Substrate overlay composite beams are tested under flexure. The beams consist of overlays of plain and fiber reinforced concretes, containing steel and macro-synthetic fibers, applied over an asphalt concrete substrate. The numerical simulation of the beams is also included in the paper. Fiber reinforced concrete is considered as a composite material made of a concrete matrix and fibers and its mechanical behavior is modeled with a simple homogenization approach based on modified mixture theory. The numerical simulation can accurately reproducematerial characterization tests and predict the bearing capacity of the composite beams. Furthermore, other substrate\/overlay alternatives are numerically studied. The numerical results could be useful to improve the design of these intervention techniques.","palabras_clave":"Fiber reinforced concrete|Overlay|Whitetopping|Pavement reinforcement|Numerical model|Composite|Fiber pull out"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19038,"idioma_id":4,"titulo":"Inexact Restoration method for nonlinear optimization without derivatives","resumen":"A derivative-free optimization method is proposed for solving a general nonlinear programming problem. It is assumed that the derivatives of the objective function and the constraints are not available. The new method is based on the Inexact Restoration scheme, where each iteration is decomposed in two phases. In the first one, the violation of the feasibility is reduced. In the second one, the objective function is minimized onto a linearization of the nonlinear constraints. At both phases, polynomial interpolation models are used in order to approximate the objective function and the constraints. At the first phase a derivative-free solver for box constrained optimization can be used. For the second phase, we propose a new method ad-hoc based on trust-region strategy that uses the projection of the simplex gradient on the tangent space. Under suitable assumptions, the algorithm is well defined and convergence results are proved. A numerical implementation is described and numerical experiments are presented to validate the theoretical results.","palabras_clave":"Inexact restoration methods|Derivative free optimization|trust region methods|polynomial interpolation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19039,"idioma_id":4,"titulo":"Diverging biological roles among human monocyte subsets in the context of tuberculosis infection","resumen":"Circulating monocytes (Mo) play an essential role in the host immune response to chronic infections. We previously demonstrated that CD16pos Mo were expanded in TB (tuberculosis) patients, correlated with disease severity and were refractory to dendritic cell differentiation. In the present study, we investigated whether human Mo subsets (CD16neg and CD16pos) differed in their ability to influence the early inflammatory response against Mycobacterium tuberculosis. We first evaluated the capacity of the Mo subsets to migrate and engage a microbicidal response in vitro. Accordingly, CD16neg Mo were more prone to migrate in response to different mycobacteria-derived gradients, were more resistant to M. tuberculosis intracellular growth and produced higher reactive oxygen species than their CD16pos counterpart. To assess further the functional dichotomy among the human Mo subsets, we carried out an in vivo analysis by adapting a hybrid mouse model (SCID\/Beige, where SCID is severe combined immunodeficient) to transfer each Mo subset, track their migratory fate during M. tuberculosis infection, and determine their impact on the host immune response. In M. tuberculosis-infected mice, the adoptively transferred CD16neg Mo displayed a higher lung migration index, induced a stronger pulmonary infiltration of murine leucocytes expressing pro- and anti-inflammatory cytokines, and significantly decreased the bacterial burden, in comparison with CD16pos Mo. Collectively, our results indicate that human Mo subsets display divergent biological roles in the context of M. tuberculosis infection, a scenario in which CD16neg Mo may contribute to the anti-mycobacterial immune response, whereas CD16pos Mo might promote microbial resilience, shedding light on a key aspect of the physiopathology of TB disease.","palabras_clave":"Bacterial Infection|Cell Movement|Monocytes|Mycobacterium Infections|Pulmonary Tuberculosis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19040,"idioma_id":4,"titulo":"Non-Hermitian oscillators with Td symmetry","resumen":"We analyse some PT-symmetric oscillators with Td symmetry thatdepend on a potential parameter g. We calculate the eigenvaluesand eigenfunctions for each irreducible representation and for arange of values of g. Pairs of eigenvalues coalesce at exceptionalpoints gc ; their magnitude roughly decreasing with the magnitudeof the eigenvalues. It is difficult to estimate whether there is aphase transition at a nonzero value of g as conjectured in earlier pa-pers. Group theory and perturbation theory enable one to predictwhether a given space?time symmetry leads to real eigenvalues forsufficiently small nonzero values of g.","palabras_clave":"PT-symmetry|Space-time symmetry|Non-hermitian hamiltonian|Multidimensional systems"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19041,"idioma_id":4,"titulo":"THE FIRING STEPS AND PHASES FORMED IN Mg-Zr-Al REFRACTORY DOLOMITE-BASED MATERIALS","resumen":"Due totheopenporemicrostructure,MgO?CaZrO3 refractory compositesareconsideredusefulmaterialsinvariousindustrialapplications.However, thereactivityoftheMgOlimitsitsutilizationinacidconditions.ThechemicalinertnessandmorebalancedmechanicalpropertiesofMgAl2O4 in comparisonwithMgObringforwardCaZrO3?MgAl2O4 refractories aspromisingalternativematerials.The presentstudywascarriedoutinordertodeterminethefeasibilityofusingArgentinedolomitesinthepreparationofCaZrO3?MgAl2O4 bysolid statereaction.Thethermalandstructuralchangeswhichoccurduringthe firing ofthebatchesupto1425 1C werestudiedbythecombination ofdiffractometricandinfraredspectroscopicdataatthemostremarkablereactionsteps.Thestudyofphasechangeswithintheinvestigated thermalrangeallowedestablishingthemaindifferencesinthecompositionofthemixturesineach firing step.Accordingtotheseresults, the final productiscomposedmainlybyMgAl2O4, CaZrO3, andCa2SiO4 phases andtheoptimalsynthesistemperaturewouldbe1425 1C. AccordingtoSEMmicroscopy,theexistenceofceramicbondingbetweenCaZrO3 and MgAl2O4 could beconfirmed.& 2014 ElsevierLtdandTechnaGroupS.r.l.Allrightsreserved","palabras_clave":"Dolomite refractories|CaZrO3MgAl2O4|FTIR spectroscopy|X-ray diffraction|SEMEDS microscopy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19042,"idioma_id":4,"titulo":"Toxoplasma gondii infection modulate systemic allergic immune response in BALB\/c mice","resumen":"The increased prevalence of allergies in developed countries has been attributed to a reduced exposure to some microbes. In agreement with epidemiological studies, we previously showed that Toxoplasma gondii infection prevents allergic airway inflammation. The mechanisms would be related to the strong Th1 response induced by the parasite and to regulatory cell induction. Herein we further characterized whether T. gondii allergy modulation extents to a systemic level or if it is limited to the lung. Parasite infection before allergic sensitization resulted in a diminished Th2 cytokine response and, when sensitized during acute infection, an increased in TGF-&#946; production was detected. Allergen specific T cell proliferation was also reduced. Sensitization during both acute and chronic phases of infection resulted in a decreased anaphylaxis reaction. Our results extend earlier work and show that, in addition to lung airway inflammation, T. gondii infection can suppress allergic responses at systemic level. These results open the possibility that this protozoan infection could modulate other allergic disorders such as atopic dermatitis or oral allergies. Understanding the mechanisms by which different microorganisms regulate inflammation may potentially lead to the development of strategies aimed to control atopic diseases","palabras_clave":"ALLERGY|TOXOPLASMA GONDII|IMMUNE-MODULATION|INFECTION|ANAPHYLAXIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19043,"idioma_id":4,"titulo":"Fabrication of TiO2 Crystalline Coatings by Combining Ti-6Al-4V Anodic Oxidation and Heat Treatments","resumen":"The bio- and hemocompatibility of titanium alloys are due to the formation of a TiO 2 layer. This natural oxide may have fissures which are detrimental to its properties. Anodic oxidation is used to obtain thicker films. By means of this technique, at low voltages oxidation, amorphous and low roughness coatings are obtained, while, above a certain voltage, crystalline and porous coatings are obtained. According to the literature, the crystalline phases of TiO 2 , anatase, and rutile would present greater biocompatibility than the amorphous phase. On the other hand, for hemocompatible applications, smooth and homogeneous surfaces are required. One way to obtain crystalline and homogeneous coatings is by heat treatments after anodic oxidation. The aim of this study is to evaluate the influence of heat treatments on the thickness, morphology, and crystalline structure of the TiO 2 anodic coatings. The characterization was performed by optical and scanning electron microscopy, X-ray diffraction, and X-ray reflectometry. Coatingswith different colors of interference were obtained. There were no significant changes in the surface morphology and roughness after heat treatment of 500 &#8728; C. Heat treated coatings have different proportions of the crystalline phases, depending on the voltage of anodic oxidation and the temperature of the heat treatment.","palabras_clave":"Coatings"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19044,"idioma_id":5,"titulo":"Comparación entre Modelos en Diferencias Finitas Aplicados a la Infiltración en Suelos","resumen":"La infiltración es el proceso por el cual penetra agua en un medio poroso, está descripta por la ecuación de Richards. Esta ecuación y las ecuaciones constitutivas asociadas son marcadamente no lineales. En este trabajo se resuelve la ecuación de Richards usando distintas aproximaciones en diferencias finitas, se analiza la velocidad de cálculo y la sensibilidad en los resultados para diferentes valores de paso de tiempo.Para la resolución se utilizaron tres métodos de cálculo; método explicito (ME), método implícito simple (MIS) y el método de Crank-Nicolson (MCN). En el problema planteado, se tomaron condiciones de frontera de Dirichlet,Se obtuvo que los tres modelos convergen a la misma solución por el análisis de sensibilidad para la variable &#916;t y que el modelo de Crank-Nicolson presenta los menores errores relativos en la zona del frente húmedo el cual, a pesar de su mayor complejidad, requiere un tiempo de cómputo reducido.","palabras_clave":"INFILTRACIÓN|SUELOS|MODELIZACIÓN|ECUACIÓN DE RICHARDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19045,"idioma_id":4,"titulo":"Inflorescence structure in koyamaeae  and its relationship with  sclerieae, bisboeckelereae, cryptagieae and trilepideae tribes (cyperoideae-cyperaceae)","resumen":"This paper aims to interpret and characterize the inflorescence of Koyamaeae tribe from the typological point of view in order to establish homologies and promote comparative studies and the use of inflorescence characters in future phylogenetic studies. The Koyamaeae tribe is comprised of one monotypic Koyamaea W. Thomas & Davidse genus, with K. neblinensis W. Thomas & Davidse. Koyamaea neblinensis has a synflorescence type II and\/or type III made up by a many-noded culm, covered by sheaths, usually unbranched (synflorescence type II), but occasionally with 1?2 branches from the upper half (synflorescence type III). The inflorescence of Koyamaea shows a main axis leading to a terminal spikelet (main florescence) and a primary branch (primary paraclade) arising from the axillary bud of the single involucral bract. Accordingly, the inflorescence is composed of the main florescence and a highly reduced paracladial zone. This paracladial zone is reduced to one node where a single primary paraclade is inserted. This primary paraclade consists of a short hypopodium, a prophyll, an epipodium and a terminal spikelet (or coflorescence). The axillary bud of the prophyll develops a secondary branch (secondary paraclade) with a similar structure to that of the primary paraclade. All subsequent higher-order branches also arise in the axils of prophylls. Inflorescence characters of this tribe are discussed in relation to related tribes","palabras_clave":"Koyamaea |Cyperoideae |Cyperaceae |Inflorescence"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19046,"idioma_id":4,"titulo":"QUANTUM CHEMICAL STUDIES ON MOLECULAR STRUCTURE, SPECTROSCOPIC (IR, RAMAN, UV-VIS), NBO AND HOMO-LUMO ANALYSIS OF 1-BENZYL-3-(2-FUROYL) THIOUREA","resumen":"Vibrational and electronic spectra for 1-benzyl-3-(2-furoyl) thiourea were calculated by using densityfunctional method (B3LYP) with different basis sets. The complete assignment of all vibrational modeswas performed on basis of the calculated frequencies and comparing with the reported IR and Ramanspectra for that thiourea derivative. UV?visible absorption spectra of the compound dissolved in methanolwere recorded and analyzed using time dependent density functional theory (TD-DFT). The calculatedvalues for the geometrical parameters of the title compound are consistent with the ones reported fromXRD studies. The stability of the molecule, related to hyper-conjugative interactions, and electrondelocalization were evaluated using natural bond orbital (NBO) analysis. Intra-molecular interactionswere studied by AIM approach. The HOMO and LUMO analysis are used to determine the charge transferwithin the molecule. Molecular electrostatic potential map was performed by the DFT method. 2015 Elsevier B.V. All rights reserved.","palabras_clave":"1-BENZYL-3-(2-FUROYL) THIOUREA|DFT CALCULATIONS|IR AND RAMAN SPECTROSCOPY|AIM APPROACH|NBO ANALYSIS|HOMO-LUMO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19047,"idioma_id":4,"titulo":"Vibrational studies (FTIR and Raman), conformational analysis, NBO, HOMO-LUMO and reactivity descriptors of S-methyl thiobutanoate, CH3CH2CH2C(O)SCH3","resumen":"In the present article, the molecular structure of S-methyl thiobutanoate, CH3CH2CH2C(O)SCH3 was determined by ab initio (MP2) and DFT calculations using different basis sets. The infrared and Raman spectra for the liquid phase were also recorded and the bands observed were assigned to the vibrational normal modes. The experimental and calculations confirm the presence of two most stable conformers, one with pseudo anti - syn conformation and another with gauche - syn conformation. The study was completed using natural bond orbital (NBO) and AIM analysis. The molecular properties like dipole moment, molecular electrostatic potential surface (MEP) and HOMO-LUMO molecular orbitals were calculated to get a better insight of the properties of the title molecule. Global and local reactivity descriptors were computed in order to predict reactivity and reactive sites on the molecule for nucleophilic, electrophilic and radical attacks.","palabras_clave":"S-METHYL THIOBUTANOATE|DFT CALCULATIONS|INTERNAL BARRIER TO ROTATION|INFRARED AND RAMAN SPECTROSCOPY|GLOBAL AND LOCAL DESCRIPTORS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19048,"idioma_id":4,"titulo":"Pharmacokinetics, safety, and efficacy of intravitreal digoxin in preclinical models for retinoblastoma","resumen":"PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two retinoblastoma and three endothelial cell types were exposed to increasing concentrations of digoxin in a conventional (72-hour exposure) and metronomic (daily exposure) treatment scheme. Cytotoxicity was defined as the digoxin concentration that killed 50% of the cells (IC50) and was assessed with a vital dye in all cell types. Induction of apoptosis and cell-cycle status were evaluated by flow cytometry after both treatment schemes. Ocular and systemic disposition after intravitreal injection as well as toxicity was assessed in rabbits. Electroretinograms (ERGs) were recorded before and after digoxin doses and histopathological examinations were performed after enucleation.RESULTS:Digoxin was cytotoxic to retinoblastoma and endothelial cells under conventional and metronomic treatment. IC50 was comparable between both schedules and induced apoptosis in all cell lines. Calculated vitreous digoxin Cmax was 8.5 &#956;g\/mL and the levels remained above the IC50 for at least 24 hours after intravitreal injection. Plasma digoxin concentration was below 0.5 ng\/ml. Retinal toxicity was evident after the third intravitreal dose with considerable changes in the ERG and histologic damage to the retina.CONCLUSIONS:Digoxin has antitumor activity for retinoblastoma while exerting antiangiogenic activity in vitro at similar concentrations. Metronomic treatment showed no advantage in terms of dose for cytotoxic effect. Four biweekly injections of digoxin led to local toxicity to the retina but no systemic toxicity in rabbits.","palabras_clave":"DIGOXIN|RETINOBLASTOMA|EFFICACY|INTRAVITREAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19049,"idioma_id":4,"titulo":"Characterization of wet granular avalanches in controlled relative humidity conditions","resumen":"This work focuses on the influence of the relative humidity (essentially due to atmospheric conditions) on the many granular media behaviours. To this end, the experimental evolution of the avalanche characteristic angles of continually tilted granular packing was studied for a wide range of relative humidities in very well controlled conditions (between 5 and 90%). The stability angles were measured for fully developed avalanches. The relationship between the relative humidity (&#981;) and cohesion of granular media (directly related to cohesion forces between grains) was then established to identify the different cohesive states of a wet granular medium using a reliable and reproducible testing methodology. Finally, a relationship between the hygroscopic equilibrium time and the stability of the granular packing is discussed.","palabras_clave":"GRANULAR|AVALANCHES|HUMIDITY|ANGLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19050,"idioma_id":4,"titulo":"Potential of High Pressure Homogenization on probiotic Caciotta cheese quality and functionality","resumen":"The functional Lb. paracasei A13, treated at 50 MPa sub-lethal High Pressure  Homogenization (HPH), was used as co-starter for producing Caciotta cheese. The cell HPH treatment  was used because proven to increase the in vitro strain functionality. The starters and Lb. paracasei  A13 viability, the cheese hydrolytic patterns and organoleptic profiles were monitored. After  cheesemaking and during ripening, the Lactobacillus paracasei A13 gastric acid resistance in cheese  and the ability of the cheese, containing HPH-treated or untreated cells, to modulate the gut mucosal  immune system in mice were evaluated. Traditional Caciotta was used as controls. The HPH-treated  probiotic strain maintained high viability for 14 days while the physico-chemical analyses on Caciotta  cheese containing HPH-treated cells showed a faster ripening, compared to other cheeses. For  functional properties, the 50 MPa treatment increased the Lb. paracasei gastric resistance in Caciotta,  maintaining high strain viability, but IL-10 producing capacity was lost by HPH-treatment while IgA  production was not modified.","palabras_clave":"FUNCTIONALITY|CACIOTTA CHEESE|HIGH PRESSURE HOMOGENIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19051,"idioma_id":4,"titulo":"Bacterial biofilms formed in arsenic-containing water: Biodeterioration of water network materials","resumen":"Theimmersion of any material in a water system triggers a surface microbialcolonization which simultaneously influences the corrosion behavior of thesubstratum. The present study was focused on the As(V) influence on the biofilmformation and their consequences on the corrosion behavior of differentsubstrata. Commercial materials used in water distribution networks: alloysbased on Fe, Zn and Cu and polypropylene (as blank) were tested in laboratorywater closed circuits either in the absence or presence of 5 mg L_1 As(V).Microbial sessile counting, microscopic techniques (SEM, ESEM, CSLM), andanodic polarization curves were performed. All the materials revealed very differentbehaviors. Except for copper, bacterial counts were higher for those couponsexposed to the water with As(V). The morphology of the corrosion products aswell as the development of the corrosion process were highly influenced by thecharacteristics of the microbial biofilm, the nature of the substrata, and thepresence or not of As(V).","palabras_clave":"ARSENIC|BIOFILM|VORROSION BEHAVIOUR|MICROBIAL INFLUENCED CORROSION|WATER NETWORK MATERIALS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19052,"idioma_id":5,"titulo":"Entornos Virtuales 3D, una propuesta educativa innovadora","resumen":"La incorporación cada vez más acelerada de las Tecnologías de la Información y la Comunicación (TIC) a la educación está generando una serie de cambios y transformaciones en el modo en el que se llevan a cabo los procesos de enseñanza y aprendizaje. Estos cambios se pueden observarse en los entornos tradicionales de la educación formal, pero también en la aparición de nuevos entornos educativos basados total o parcialmente en las TIC. Este documento se centra en el diseño, creación y coordinación de un entorno virtual 3D [EV3D] de enseñanza y aprendizaje. En él se plantea la definición e implantación de un modelo de entorno virtual 3D, haciendo enfoque no sólo en el plano técnico y pedagógico, sino que también en una metodología de transición que permita mejorar la calidad de los métodos y técnicas de enseñanza.","palabras_clave":"EV3D|PACIE|E-LEARNING|OPENSIM|TIC|SBS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19053,"idioma_id":4,"titulo":"Use of Borom and Lithium Oxides as a Replacement of Fluoride Compounds in Mold Powders","resumen":"Abstract: The demands on the care of the environment, has impulsed the researchers to develop new mold powders without fluor content in their composition. Nevertheless, the new products need cover the important process requirements and avoid metallurgical problems. The main reason of the substitution of fluoride compounds is associated with emissions of fluorinated gases that cause health problems in operators. Also, provoke environment contamination and cooling water that could cause serious damage or corrosion on the equipment in the industrial plants. In the steel continuous casting process, the presence of a lubricant layer between the oscillating mold and the steel shell formed (during the first stage of solidification) is essential to ensure the good quality of the product. This layer should permit the transfer of heat from the liquid steel to the cooling water in the mold and ensure good physical properties in order to achieve the required lubrication. The use of mold powder, which forms a liquid slag film in the space between the steel shell and the mold, is now standard practice in the continuous casting process. That is why the design of these products acquires a significant importance. This paper presents a comparative characterization of a commercial mold powder and a synthetic slag without fluor compounds, designed in the laboratory. The oxides used in order to replace fluorine are B2O3 and Li2O. The results include physical properties such as viscosity at different process temperatures. These values obtained, by theoretical calculus using Riboud model, were compared with results estimated applying the software Fact Sage. In order to predict heat transfer behavior of both slags, the crystallization tendency was studied by experimental tests. The crystalline and glassy phases identification, were carried out by light and scanning electron microscopy (SEM\/EDS) and checked by X ray diffraction (XRD). A thermodynamic simulation of the systems using Fact Sage corroborated the information obtained.","palabras_clave":"MOULD POWDER|VISCOSITY|CRYSTALLIZATION TENDENCY|ENVIROMENT|CONTINUOUS CASTING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19054,"idioma_id":4,"titulo":"Preparation and characterization of grafted cellulosic fibers and their  applications in protein purification","resumen":"Fibrous adsorbents were subjected either to chemical treatment or gamma   irradiation to introduce epoxide groups onto their cellulosic backbone   using glycidyl methacrylate. These epoxide moieties were modified to   have diethylaminoethanol (DEAE) as well as quaternary ammonium (Q)   functionalities. The resulting anion-exchange adsorbents were   characterized by their FTIR spectra and ionic capacities. The   fiber-based adsorbent systems showed similar packing efficiency to the   commercially available adsorbents, where the Péclet number values were   &#10878;60, suggesting near-plug-flow conditions. The total ionic capacities   obtained for these chemically grafted adsorbents were ca. 400&nbsp;mmol\/L. These adsorbents showed dynamic binding capacities (DBC) of ca.   48&nbsp;mg\/mL for bovine serum albumin (BSA). Protein binding capacities   obtained from chemical grafting initiation techniques were   18-fold-higher than radiation-induced techniques. The advantage of these   adsorbents lies in their high operational flow rates while maintaining   their high binding capacities.","palabras_clave":"CHROMATOGRAPHY|PURIFICATION|RADIATION|GRAFTING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19055,"idioma_id":4,"titulo":"Glycerol oxidation in liquid phase: Highly stable Pt catalysts supported on ion exchange resins","resumen":"tThe glycerol oxidation reaction in liquid phase was studied using platinum supported on ion exchangeresin as catalysts, with the objective of obtaining glyceric acid. In particular, the effect of the competitoranion, which is the ion used during the support pre-treatment, was addressed. It was found that thecompetitor ion affects the radial distribution of the active metal in the resin sphere. As the adsorptionequilibrium constant of the competitor ion increases, the penetration of platinum in the resin particle alsoincreases. Nevertheless, this difference did not affect the catalytic performance. However, the presence ofiodide as competitor ion affected the platinum chemical environment, thus modifying the platinum activesites in this catalyst. Such effect was not observed when chloride or citrate ions were used for the resinpretreatment. Therefore, the competitor ion effect on the platinum catalysts performance is related withthe ion nature more than with its affinity for the resin exchange sites. Iodide is adsorbed by platinum, andconsequently, it affects its electronic state improving the selectivity. These catalysts showed very goodactivity, and what is also very important, very good stability, being possible to maintain the conversionand selectivity for many reaction cycles.","palabras_clave":"GLYCEROL|GLYCERIC ACID|PLTINUM|ION EXCHANGE RESIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19056,"idioma_id":4,"titulo":"Estimation of ecosystem metabolism from diel oxygen technique in a saline shallow lake: La Salada (Argentina)","resumen":"Studies based on continuous monitoring of diel changes in dissolved oxygen concentration allow the estimation of ecosystem metabolism and provide a measure of the overall trophic processes of an ecosystem. In this study, net ecosystem production (NEP), community\/ecosystem respiration (R), and gross primary production (GPP) rates were estimated in relation to physicochemical and climatic variables for 18 months in La Salada, a saline shallow lake. Net  autotrophic conditions prevailed during the study period (NEP: 64.05 ± 44.22 mmol O2 m-2 day-1).  GPP and R were positively correlated and were synchronized on a daily timescale, with GPP typically greater than R. Principal component analysis revealed that monthly rates of GPP, R, and NEP responded, as expected, to temperature and light seasonal patterns.  Water level and conductivity fluctuations, because of apo concentration and water management, were relevant as a driver of the physicochemical and biological characteristics of the lake. In saline lakes as La Salada, an adequate management of water resources will be relevant to maintain the ecosystem equilibrium and the quality of its resources.","palabras_clave":"SHALLOW LAKES|LA SALADA|METABOLISMO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19057,"idioma_id":4,"titulo":"Cytokine-Enhanced Vaccine and Interferon-b plus Suicide Gene Therapy as Surgery Adjuvant Treatments for Spontaneous Canine Melanoma","resumen":"We present here a nonviral immunogene therapy trial for canine malignant melanoma, an aggressive diseasedisplaying significant clinical and histopathological overlapping with human melanoma. As a surgery adjuvantapproach, it comprised the co-injection of lipoplexes bearing herpes simplex virus thymidine kinase and canineinterferon-b genes at the time of surgery, combined with the periodic administration of a subcutaneous geneticvaccine composed of tumor extracts and lipoplexes carrying the genes of human interleukin-2 and humangranulocyte-macrophage colony-stimulating factor. Following complete surgery (CS), the combined treatment(CT) significantly raised the portion of local disease-free canine patients from 11% to 83% and distant metastases-free (M0) from 44% to 89%, as compared with surgery-only-treated controls (ST). Even after partialsurgery (PS), CT better controlled the systemic disease (M0: 82%) than ST (M0: 48%). Moreover, comparedwith ST, CT caused a significant 7-fold (CS) and 4-fold (PS) rise of overall survival, and > 17-fold (CS) and> 13-fold (PS) rise of metastasis-free survival. The dramatic increase of PS metastasis-free survival ( > 1321days) and CS recurrence- and metastasis-free survival (both > 2251 days) demonstrated that CT was shifting arapidly lethal disease into a chronic one. In conclusion, this surgery adjuvant CT was able of significantlydelaying or preventing postsurgical recurrence and distant metastasis, increasing disease-free and overall survival,and maintaining the quality of life. The high number of canine patients involved in CT (301) and theextensive follow-up ( > 6 years) with minimal or absent toxicity warrant the long-term safety and efficacy of thistreatment. This successful clinical outcome justifies attempting a similar scheme for human melanoma.","palabras_clave":"IL-2|GM-CSF|HSV-TK|IFN-B|MELANOMA-VACCINE|LIPOFECTION|DMRIE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19058,"idioma_id":4,"titulo":"Physicochemical properties of Films Based on Bovine Gelatin Cross-linked with 1,4-butanediol Diglycidyl Ether.","resumen":"The effectiveness of 1,4­butanediol diglycidyl ether (BDDGE) as a crosslinking agent of bovine gelatin films plasticized with D­sorbitol intended for  food  packaging  is  reported.  Free­standing  films  were  produced  by casting gelatin film­forming solutions containing D­soritol 30 % (g\/100 g dry gelatin) and variable amounts of BDDGE (0?3 g\/100 g dry gelatin). The addition of 1 % BDDGE (g\/100 g dry gelatin) positively influenced the solubility,  water  vapor  permeability,  and  mechanical  properties  of  the produced films. Water solubility decreased about 77 %&#894; the water vapor permeability enhanced 20 %, and the stretching ability increased 11 times while the tensile strength was reduced up to 7­fold with regard to the noncross­linked  counterpart.  A  simple  extraction  procedure  was  applied  to remove the potential un­reacted BDDGE and its hydrolysis products from BDDGE­treated  gelatin  films.  Quantification  was  performed  by  gas chromatography combined with mass spectrometry (GC\/MS), being lower than  0.25  &#956;g\/kg  (below  the  limit  of  detection,  0.30  &#956;g\/L).  Results  suggested  that  water­soluble  BDDGE  may  provide  an  effective  crosslinking  alternative  to  the  usual  aldehyde­based  strategy  to  manufacture gelatin films with potential use as biodegradable food packaging materials","palabras_clave":"GELATIN FILMS|CROSS-LINKING|FUNCTIONAL PROPERTIES|QUANTIFICATION OF RESIDUAL CROSS-LINKING AGENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19059,"idioma_id":4,"titulo":"Oregano and lavender essential oils as antioxidant and antimicrobial additives of biogenic gelatin films","resumen":"tThe chemical composition of the essential oils obtained by hydrodistillation from fully-formed, driedoregano leaves (Origanum vulgareOriganum vulgare) and lavender leaves and flowers (Lavandula offic-inalis) were analyzed by GC\/MS. The effectiveness of oregano (OEO) and lavender (LEO) essentialoils and a mixture LEO:OEO (50:50) in inhibiting Escherichia coli and Staphylococcus aureus growthwere determined. Both essential oils inhibited the growth of the microorganisms tested, being moresensitive to gram-positive bacteria. OEO yielded the lowest values of minimum inhibitory con-centration (MICOEO= 1600?1800 ppm vs. MICLEO= 2000 ppm against E. coli; MICOEO= 800?900 ppm vs.MICLEO= 1000?1200 ppm against S. aureus), due to the higher content of phenolic compound, which alsoprovides antioxidant capacity (IC50OEO= 297 ± 89 ppm vs. IC50LEO» 6000 ppm). Mixture results indicatedan antagonist antimicrobial effect between OEO and LEO. Gelatin-based films added with OEO or LEO,were prepared by casting (2000?6000 ppm). Mechanical, optical and water vapor barrier properties weredetermined to observe film functionality. OEO effect on the functional properties of gelatin films was notsignificant. LEO, in the highest concentration analyzed, promotes a slight change in water vapor perme-ability of Ge-based films (1.46 × 10&#8722;13to 6.8 × 10&#8722;14Kg.m\/Pa.s.m2), due to its high hydrophobic nature.Oregano containing gelatin films exhibited the highest antimicrobial and antioxidant properties.","palabras_clave":"ACTIVE FILMS|ESSENTIAL OILS|GELATIN|ANTIMICROBIAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19060,"idioma_id":5,"titulo":"ESTUDIO DE LA ESTRUCTURA DE QUESOS FUNCIONALES CON EL ADICIONADO DE SEMILLAS DE CHÍA MEDIANTE EL ANÁLISIS DIGITAL DE IMÁGENES","resumen":"En los últimos años, en la industria quesera las aplicaciones se han centrado en el estudio de las relaciones entre la microestructura, la textura y las propiedades sensoriales, que constituyen un parámetro de interés para la optimización de las prácticas de fabricación. El reto es cómo disminuir o eliminar el colesterol de estos productos, sin eliminar totalmente la grasa, que aporta vitamina A y D, ácidos grasos esenciales, flavor y propiedades texturales. Por esta razón, en el presente trabajo se evaluó la microestructura en quesos tipo untables reducidos en grasa y en colesterol, adicionados con harina de semillas de chía, mediante el análisis digital de imágenes. Al comparar la microestructura en función del mayor o menor contenido en grasa pero igual porcentaje de harina de chía, se pudo concluir que los quesos con mayor contenido en grasa (10%MG) mostraban cavidades libres de mayor tamaño y una matriz más heterogénea que los quesos con menor contenido en grasa (6%MG). Por otro lado, al comparar los parámetros de textura de las imágenes se observó, que para un mismo contenido de chía, la entropía de la escala de grises aumentaba y la uniformidad disminuía con el contenido de materia grasa, lo cual podría estar relacionado con una mayor variabilidad en el tamaño de las cavidades. Esto tiene relación con los datos obtenidos previamente mediante el análisis del perfil de textura, donde se observó que a medida que aumentaba el % de materia grasa también se incrementaba el parámetro Dureza y el valor de Consistencia.","palabras_clave":"MICROESTRUCTURA|ANALISIS DE IMAGENES|SEMILLAS DE CHIA|QUESOS FUNCIONALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19061,"idioma_id":4,"titulo":"Soil ecotoxicity assessment of glyphosate  use under field conditions: microbial activity  and community structure of Eubacteria  and ammonia-oxidising bacteria","resumen":"BACKGROUND: A plot-scale experiment was conducted to assess the impact of field application rates of glyphosate on soil microbial communities by taking measurements of microbial activity (in terms of substrate-induced respiration and enzyme activity) in parallel with culture-independent approaches to assessing both bacterial abundance and diversity. Two rates of glyphosate, alone or in a mixture with 2,4-dichlorophenoxyacetic acid, were applied directly onto the soil surface, simulating normal use in chemical fallow in no-till systems.RESULTS: No consistent rate-dependent responses were observed in the microbial activity parameters investigated in the field plots that were exposed to glyphosate. Denaturant gradient gel electrophoresis (DGGE) of the overall bacterial community (Eubacteria) and ammonia-oxidising bacteria (AOB) revealed no effects of the high rate of glyphosate on the structure of the communities in comparison with the control. No treatment effects were observed on the abundance of Eubacteria shortly after treatment in 2010, while a small but significant difference between the high rate and the control was detected in the first sampling in 2011. The abundance of AOB was relatively low during the study, and treatment effects were undetectable.CONCLUSIONS: The absence of negative effects on soil microbial communities in this study suggests that glyphosate use at recommended rates poses low risk to the microbiota.","palabras_clave":"GLYPHOSATE|SOIL MICROBIAL COMMUNITY|MICROBIAL ACTIVITY|QUANTITATIVE PCR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19062,"idioma_id":5,"titulo":"Estructura y composición del fitoplancton de Mina Piquitas (Jujuy, Argentina","resumen":"--","palabras_clave":"taxonomía|bioindicadores|acidificación|minería"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19063,"idioma_id":4,"titulo":"Rock magnetism in two loess-paleosol sequences in Córdoba, Argentina","resumen":"This work presents new rock magnetic resultsalong two loess?paleosol profiles in nearby locations inArgentina. The main objective of this study is to comparethe magnetic signals and mineral content of two profiles anddetermine if the climate during Marine Isotope Stage 5(MIS 5) and MIS 3 were similar to the present one. The twoprofiles are located in two different geomorphological settings,with effects on the water saturation characteristicsand seasonality. Selected samples taken at these profileswere analyzed using laboratory procedures and environmentalmagnetism parameters to determine the climaticinfluence during the Late Pleistocene. Despite their proximitythere are several differences between both profiles,such as their depth and geomorphological positions amongothers. The results of these analyses led to the followingconclusions: climate conditions during MIS 5 were verysimilar to those of the present conditions. The hypothesisfor this area suggests a slight increase in the magnetic signal","palabras_clave":"Rock magnetic properties|loess and paleosol sequences"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19064,"idioma_id":4,"titulo":"Chitosan molecular weight effect on starch-composite film properties","resumen":"The aim of this work was to prepare and characterize composite films based on chitosan (CH) and corn starch (CS), analyzing the in&#64258;uence of the chitosan molecular weight (MW) on film structure and functional properties. Three chitosan products were characterized and classified as low (LMW), medium (MMW) and high (HMW) according to its MW. Rheological behavior of filmogenic solutions depend on CH-MW from Newtonian to pseudoplastic one. Chitosan based film physicochemical properties were strongly affected by its molecular weight: the lower the MW the higher the color differences and film solubility. SEM observations demonstrated that plasticized chitosan films exhibited homogeneous structures, the higher the MW the more compact is the structure and the lower is the water vapor permeability (WVP, 4.55&nbsp;±&nbsp;0.6&nbsp;×&nbsp;10&#8722;11&nbsp;g\/m&nbsp;s&nbsp;Pa.). Likewise, CH and CS were compatible polymers which led to the development of homogeneous blend films. Polymer interactions were evidenced in FTIR spectra by the shifts observed within the region of 1500?1700&nbsp;cm&#8722;1, which reduce the hydrophilic groups? availability of chitosan matrices, leading to a reduction in WVP of composite films. Mechanical properties of the developed films were performed through different complementary tests. Chitosan MW affects both the type and number of interactions, which determine the matrix structure and characteristics. In HMW-CH matrix polymer?polymer interactions are favored, leading to strong and resistant matrices with high dynamic elastic modulus values. Meanwhile, in LMW-CH one, polymer-plasticizer and polymer?solvent interactions became important and the development of high extensible and soluble materials is privileged.","palabras_clave":"CHITOSAN MOLECULAR WEIGHT|STARCH|MECHANICAL PROPERTIES|WATER VAPOR PERMEABILITY|PHYSICO-CHEMICAL PROPERTIES|MICROSTRUCTURAL ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19065,"idioma_id":4,"titulo":"Hamming Graph based Image Compression with variable Threshold","resumen":"In this paper a lossy image compression methodusing the adjacency matrix of a graph is proposed.We instantiate the method using the Hamming graph,which gives rise to an image compression algorithmthat uses a Hadamard Matrix together with a thresholdapproach. In threshold methods, selection of thecorrect (static) threshold value is difficult. In our approachwe use a new threshold determination thatchanges from block to block obtaining an algorithmthat uses only integer and modular operations andobtains good results in some standard images. Thenew method has better stability under recompressioniteration than jpg.","palabras_clave":"Hamming Graph |Image Compression"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19066,"idioma_id":4,"titulo":"Ab-initio Studies of Structure, Electronic Properties and Relative Stability of SnO2 Nanoparticles as a Function of Stoichiometry, Temperature and Oxygen Partial Pressure","resumen":"   Relative stability of nanocrystals of rutile SnO$_2$ with defined sizes and controlled stoichiometry was studiedallowing the full relaxations of nanoparticle (NP) atoms.Once stabilized in energy, the structure was analyzed by a refinement of the pair distribution function (PDF) of the Sn-Sn and Sn-O pairs. The calculated pair distribution functions G$_{calc}$(r), of our NP´s larger than 3 nm, indicate a rutile crystalline core of 2.4 nm size, which are well compared with recent G$_{exp}$(r) determined from XRD experiments. Therefore distorted surface layers are decreased to 0.25-0.30 nm width, for stoichiometric and oxygen in excess NP´s.  This finding is confirmed by the inspection of the core electronic density of states (DOS), determined withthe projected density of states (PDOS) of atoms included in radii sizes of 0.5, 0.7, 0.9. 1.1, and 1.5 nm.  The deviation of the NP total DOS from the bulk total DOS is analyzed inspecting the PDOS contributions of cation and anion sublattices, for atoms placed in the core, in the distorted layer and in the NP surface. In particular, oxygen atoms at the surface can bound forming dimers and trimers whose electronic states can fix the NP Fermi levels and then acting as active centers. The dependence of thermodynamic stability of the NP´s with oxygen pressure and temperature is studied. It was found that at normal O$_2$ pressures and T350K, the stable NP is the defficient in oxygen one. We also studied the changes of Mulliken populations of Sn and O atoms with respect to the bulk. We found more important variations in those atoms located close or at the surface. These changes strongly depends on NP stoichiometry. This study therefore help to improve the understanding of the electronic and thermodynamic properties of SnO$_2$ nanocrystals  at actual environment conditions of operations in gas sensor devices.","palabras_clave":"Nanoparticles|Ceramics Semiconductors|Ab-initio Calculations|Gas Sensors"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19067,"idioma_id":4,"titulo":"THERMAL DECOMPOSITION OF CYCLIC GLUTARALDEHYDE DIPEROXIDE. UV.SPECTROSCOPIC ANALYSIS","resumen":"The thermal decomposition reaction of Cyclic GlutaraldehydeDiperoxide (3,6-dibutanal-1,2,4,5-tetroxane) in solution of methanol in the temperature range of 130.0-166.0ºC and initial concentration of 1.69 x10-3mol\/L, follows first-order kinetic laws. Under the experimental conditions, the activation parameters of the reaction are bigger than the obtained ones for other tetroxanos with different substituent's in the same solvent, which indicates us that the substituents stabilize the condition of transition decreasing the energetic barrier.","palabras_clave":"DPG|DECOMPOSITION |SOLVENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19068,"idioma_id":4,"titulo":"Metallothionein and lipid peroxidation as markers to assess health status of chronically oiled Magellanic penguins in Argentina","resumen":"Chronic oiling affects seabirds, with short (individual survival) and long term (dynamics of population) effects. Magellanic penguin is the most affected species in Argentina. The aim was to evaluate the use of blood biochemical-molecular biomarkers (MT and TBARs) to assess health status of Magellanic penguin exposed to chronic environmental oiling, in addition with routine hematological analyses (differential WBC count and PCV). Oiled specimens presented significant higher RBC, metallothionein and TBARs concentrations than those from shelter; while routine hematological parameters were within normal levels for penguins and did not show any difference between both groups. These results demonstrated the higher sensibility of both biomarkers, evidencing effects on health status by chronic oiling; furthermore, they are the first report in blood metallothionein and oxidative stress in S. magellanicus. These studies will be useful for a better assessment of the health condition in rehabilitation centers (short term); and, as early warning signals in natural colonies (long term).","palabras_clave":"Metallothionein|S. magellanicus|Chronic oiling affects"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19069,"idioma_id":4,"titulo":"Expertise, Working Memory and Articulatory Suppression Effect: their relation with Simultaneous Interpreting Performance","resumen":"Simultaneous interpreting is a complex bilingual verbal activity that involves the auditory perception of an oral communication and the production of a coherent discourse. One of the cognitive functions underlying simultaneous interpreting is working memory. The aim of this work was to study the relationship among expertise, working memory capacity and articulatory suppression effect with the ability to perform simultaneous interpreting. For this purpose, four working memory tasks and one simultaneous interpreting task were administered to thirty Spanish-speaking professional English interpreters. Results showed that simultaneous interpreting ability might be supported by the capacity of working memory to store or process information, but also by the ability of the interpreter to cope with the articulatory suppression effect.  We conclude that interpreters may either have or develop a resource to support the effect caused by articulatory suppression.        Con Referato. ISSN: 1895-1171.   Indexada en: Thomson Reuters, Scopus, PsychINFO, Medline, EBSCO, Ministry of Science and Higher Education list of scored journals, Directory of Open Access Journals (DOAJ), ERIH PLUS","palabras_clave":"WORKING MEMORY|ARTICULATORY SUPRESSION|SIMULTANEOUS INTERPRETING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19070,"idioma_id":5,"titulo":"Estructura de la memoria de trabajo en jóvenes adultos y su relación con 'g'","resumen":"En la década del ?80 muchos investigadores comenzaron a aseverar que la memoria de trabajo (MT) y ?g? se encuentran estrechamente relacionadas. Estas afirmaciones comenzaron a partir de los estudios de Daneman y Carpenter (1980) y se consolidaron con los trabajos de Kyllonen y Christal (1990). El objetivo general de este trabajo es estudiar si los componentes pasivos de la MT tienen un rol mediador en la relación entre los componentes de almacenamiento y procesamiento concurrente y ?g?, explorando primero la estructura de la MT en jóvenes adultos. Para ello trabajó con una muestra de 170 estudiantes universitarios con una media de edad de 22.42 años (DE = 3.95), a los que se les administró la Batería Automatizada de Memoria de Trabajo (Alloway, 2007; Injoque-Ricle, Calero, Alloway, & Burin, 2011), las tareas de Razonamiento Abstracto y Razonamiento Verbal del Test de Aptitudes Diferenciales (Bennett, Seashore, & Wesman, 1992). En cuanto a la estructura de la MT, los resultados muestran que en jóvenes adultos tiene una conformación de cuatro componentes: dos de almacenamiento, y dos de almacenamiento y procesamiento concurrente, separados en función de la modalidad de la información que manejan. Con respecto a la Relación entre la MT y ?g?, el modelo propuesto arrojó un efecto indirecto de mediana intensidad entre la MT viso-espacial y ?g? mediado por la memoria de corto plazo viso-espacial. El efecto indirecto de la MT verbal sobre ?g? mediado por la memoria de corto plazo verbal es de baja intensidad. Indexada en: Latindex (Catálogo), RedALyC, Dialnet, PSICODOC, LILACS, BVS, EBSCO (Publishing), IMBIOMED, DOAJ, e-Revistas, Núcleo Básico de Revistas Científicas Argentinas","palabras_clave":"MEMORIA DE TRABAJO|G|ANALISIS FACTORIAL CONFIRMATORIO|ANALISIS DE SENDEROS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19071,"idioma_id":5,"titulo":"Diferencias Individuales en la Comprensión de Textos Expositivos Revisados","resumen":"El objetivo de este trabajo fue estudiar el rol de la memoria de trabajo en la comprensión de información literal e inferencial de textos revisados bajo dos métodos: el procedimiento basado en la repetición de términos y el procedimiento basado en el incremento de la densidad de relaciones. Para ello, 48 estudiantes universitarios identificados previamente como de alta y baja capacidad de memoria de trabajo, leyeron textos expositivos revisados bajo los dos métodos mencionados, y respondieron a preguntas acerca del contenido literal e inferencial. Los resultados indicaron que en la comprensión del contenido literal del texto revisado bajo el método de incremento de la densidad de relaciones, los sujetos de alta y baja capacidad de memoria de trabajo no se diferenciaron entre sí, como ocurre en el texto original y revisado con el método de repetición de términos. En las preguntas inferenciales, los lectores de alta capacidad se desempeñan mejor que los de baja capacidad en todas las versiones.  Los hallazgos de este estudio sugieren que el método de incremento de la densidad de relaciones facilita la comprensión de información literal, pero la memoria de trabajo tiene un rol importante en cuanto a la generación de inferencias. Indexada en: Latindex (Catálogo), PSICODOC, LILACS, IUPsyS,","palabras_clave":"MEMORIA DE TRABAJO|REVISION DE TEXTOS|COMPRENSIÓN|TEXTO EXPOSITIVO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19072,"idioma_id":4,"titulo":"TERPENE KETONES AS NATURAL INSECTICIDES AGAINST SITOPHILUS ZEAMAIS","resumen":"The eleven terpene ketones, thymoquinone, (R)-carvone, (S)-carvone, pulegone, dihydrocarvone, men-thone, verbenone, ocimenone, camphor, -thujone and piperitenone, were tested as contact and fumigantinsecticides against adults of Sitophilus zeamais Motschulsky under laboratory conditions. The resultsshow that thymoquinone was found to be more toxic than the other ketones, with lethal doses valuesbeing LC5016.5 g\/cm2and LC5013.8 L\/L air (24 h after treatment). These ketones were also subjectedto multiple regression analysis and the results derived from the quantitative structure activity relation-ship (QSAR) model suggested two topological indicators, the Balaban and Randic indices, were the bestdescriptors of insecticidal activity of the ketones. However, orbital electronegativity of the carbonyl groupwas the main parameter that connected the inhibition activity of ketones on acetylcholinesterase (AChE).Thus, the insecticidal activity of terpene ketones was primarily explained by the shape of molecules andthe branching of the carbon-atom skeleton, while inhibition of activity of AChE was mainly due to theelectronic descriptors.","palabras_clave":"TERPENE KETONE|INSECTICIDE|ACETYLCHOLINESTERASE|QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19073,"idioma_id":4,"titulo":"Effect of fungal volatile organic compounds on a fungus and an insect that damage stored maize","resumen":"The silo is an environment where a large number of biological interactions take place such as: insect-microorganism-grain interactions, which can generate great economic losses due to the deterioration in quality of the grain and the presence of mycotoxins. In recent years, particular interest has been focused on the search for environmentally friendly insecticides that will provide pest control in stored grains. The volatile organic compounds (VOCs), of a fungal origin, were evaluated for the control of maize grain pests: the insect Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae), the fungus Fusarium verticillioides and its mycotoxin, fumonisin B1 (FB1). The most active fumigant compound tested was 1-octen-3-ol (LD50 = 27.7 µL\/L air), followed by 3-octanol and 3-octanone (LD50 = 43.2 and 219.7 µL\/L air, respectively). The fungal VOCs also showed repellent activity against S. zeamais, with antifugal activity against F. verticillioides growth being inhibited at concentrations greater than 0.53 mM, while its mycotoxin production capacity was inhibited depending on the compound concentration. At the repellent concentration, the fungal VOCs showed low phytotoxicity activities. The results presented in this paper demonstrate the potential of fungal VOCs as biopesticides, because they may control granivorous insects, fungal growth and FB1 production, which consequently is of economic importance and might improve food safety of stored grains.","palabras_clave":"VOLATILE|SITOPHILUS ZEAMAIS|FUSARIUM VERTICILLIOIDES|FUMONISIN|INSECTICIDE|FUNGICIDE ACTIVITIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19074,"idioma_id":4,"titulo":"A bayesian approach to inferring the genetic population structure of sugarcane accessions from INTA (Argentina)","resumen":"Understanding the population structure and genetic diversity in sugarcane accessions from INTA (Instituto Nacional de Tecnología Agropecuaria) germplasm bank (Argentina) will be of great importance for germplasm collection and breeding improvement as it will identify diverse parental combinations to create segregating progenies with maximum genetic variability for further selection. A Bayesian approach, ordination methods (PCoA, Principal Coordinate Analysis) and clustering analysis (UPGMA, Unweighted Pair Group Method with Arithmetic Average) were applied to this purpose. Sixty three INTA sugarcane hybrids were genotyped for 107 SSR and 136 AFLP loci. Given the low probability values found with AFLP for individual assignment (4.7%), microsatellites seemed to perform better (54%) for STRUCTURE analysis that revealed the germplasm to exist in five optimum groups with partly corresponding to their origin. However clusters shown high degree of admixture, mean FST values confirmed the existence of differences among groups. Dissimilarity coefficients ranged from 0.079 to 0.651. PCoA separated sugarcane in groups that did not agree with those identified by STRUCTURE. The clustering including all genotypes neither showed resemblance to populations find by STRUCTURE, but clustering performed considering only individuals displaying a proportional membership > 0.6 in their primary population obtained with STRUCTURE showed close similarities. The Bayesian method indubitably brought more information on cultivar origins than classical PCoA and hierarchical clustering method.","palabras_clave":"AFLP|Bayesian clustering|Sugarcane"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19075,"idioma_id":4,"titulo":"Gross Nitrogen Mineralization and Immobilization in Temperate Maize-Soybean Intercrops","resumen":"Background and aims Reliance on nitrogen (N) fertilizers to maintain crop productivity requires a thorough understanding of the transformation of this nutrient within the soil-plant system. Organic matter input from a mixture of crop residues, such intercrop systems, influence N transformations differently compared to sole crops. We tested the hypothesis that N mineralization  and immobilization differ between cereal-legume intercrops and sole crops.  Methods A short-term experiment using 15N isotopic pool dilution was conducted in 2007 and 2012 in maize (Zea mays L.) and soybean (Glycine max L. Merr.) sole  crops and 1:2 (1 row maize:2 rows soybean) and 2:3 (two rows maize:3 rows soybean) intercrops. Soil characteristics, grossmineralization and immobilization, and net immobilization to a 10 cm depth were quantified.  Results Soil characteristics (pH, bulk density, soil organic carbon (C), total N, and C:N) were not significantly different (P<0.05) among treatments,  but differed significantly (P<0.05) between years (2007 vs. 2012). Soil NH4  +-N was significantly lower (P<0.05) in the maize sole crop. Gross N mineralization, immobilization and net immobilization, were significantly  different (P<0.05) among treatments and between years. Relative NH4  +-N immobilization was significantly different (P<0.05) among treatments and  between years, showing the lowest values in the intercrops.  The amount of NH4 +-N mineralized per day was significantly greater (P<0.05) in the 2:3 intercrop and was significantly different (P<0.05) between years  in the 2:3 intercrop. Residence time of NH4 +-N was significantly longer (P<0.05) in the soybean sole crop and 1:2 intercrop followed by the 2:3 intercrop and the maize sole crop.  Conclusions Intercropping contributed to the long-term immobilization of N and therefore was a more sustainable land-management practice than sole cropping. The adoption of cereal-legume intercrops will curb our currently growing reliance on N fertilizers.","palabras_clave":"Argentina pampas|cereal-legume|crop residue|isotope techniques"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19076,"idioma_id":5,"titulo":"La modelización algebraica como una vía de entrada para los negativos","resumen":"Esta investigación se inicia a partir del reconocimiento de la brecha que existe entre ?la teoría y la práctica?.  Se propuso adaptar  ?en  forma colaborativa profesores e investigadores?  una propuesta de enseñanza en relación a la introducción de los números negativos en un entorno algebraico, para ser puesta en aula con alumnos de primer año de la escuela secundaria. Para que resultados de investigaciones se conviertan en insumos  para la enseñanza y los docentes se apropien de los mismos, es importante un proceso-acompañamiento que abra el juego a la explicitación de las ideas y de las acciones. En este caso, la modelización algebraica y el estudio de los programas de cálculo algebraicos requirieron de un proceso de sucesivas aproximaciones que  llevó a la reformulación de actividades para implementarlas en el aula. Se muestra parte de esta adaptación, con la intención de echar luz sobre las nociones involucradas.","palabras_clave":"colaborativo|números negativos|modelización algebraica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19077,"idioma_id":4,"titulo":"Color and Bioactive Compounds Characteristics on Dehydrated Sweet Cherry Products","resumen":"Abstract It is widely known that quality properties of fruits  can be affected by drying processes. The approach was the  quality improvement of dried cherry products through the application  of combined technologies of drying and pretreatments.  The objective of this work was to analyze the effect  of blanching or sugar infusion prior to air-drying or freezedrying  on quality properties such as color, bioactive compounds,  and antiradical power of two cherry products (discs  and dices). Air-drying caused darkening, whereas freezedrying  provoked higher lightness of discs compared to fresh  fruit (p&lt;0.05). Cherry dices were lighter than the fresh fruit. A  high retention of total anthocyanin (ACY) and phenolic content  (TPC) was obtained in blanched freeze-dried discs  (ACY=165±22 mg Cyd-3-glu\/100 g d.w.; TPC=739±  55 mg GAE\/100 g d.w.). Sugar infusion pretreatment caused  an important decrease in ACY (31?89 mg Cyd-3-glu\/100 g  d.w.) and TPC (222?271 mg GAE\/100 g d.w.). When  blanching was applied prior to air-drying, samples presented  the highest antiradical power, similar to that observed in fresh  fruit. In dices, the best quality attributes in terms of superficial  color were found in control freeze-dried samples since they  presented minor shifts in hue angle and a greater preservation  of anthocyanin pigments (ACY=211±30 mg Cyd-3-glu\/  100 g d.w.). However, control air-dried dices presented the  highest phenolic content (TPC=771±65 mg GAE\/100 g d.w.).  Regarding the possible application of the dry cherry products,  discs could be directly consumed as snacks,while dices could be  incorporated as ingredients in fruit bars, cookies, or muffins.","palabras_clave":"SWEET CHERRY|AIR-DRYING|FREEZE-DRYING|BLANCHING|SUGAR INFUSION|COLOR|BIOACTIVE COMPOUNDS|ANTIRADICAL POWER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19078,"idioma_id":4,"titulo":"Phospholipase A2 enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis","resumen":"Microvessel disruption leading to hemorrhage stands among the most dangerous consequences of envenomings by snakes of the family Viperidae. A PIII metalloproteinase (SVMP), balteragin, purified from the venom of the snake Bothrops alternatus, displays a potent hemorrhagic effect, and a moderate myotoxicity in vivo. Previous studies described the ability of this SVMP to induce the detachment of C2C12 myoblasts in culture, without causing cytolysis. Surprisingly, a purified acidic phospholipase A2 (PLA2) from the same venom was found to increase this detaching activity of the SVMP on myoblasts. Since endothelial cells are a natural target of SVMPs in vivo, the possibility that this synergistic effect is also observed on this cell type was explored in the present work. In addition, a first approach of the mechanism of action of this effect was studied. Results clearly confirm that the acidic PLA2, despite lacking toxicity towards endothelial cells, significantly enhances the detaching effect of the SVMP even at a concentration as low as 1 &#956;g\/mL. Inhibition of enzymatic activity of the PLA2 by chemical modification with p-bromophenacyl bromide did not affect the synergistic activity, suggesting that this effect is not dependent on phospholipase enzymatic activity and may instead be the consequence of an interaction of the PLA2 with endothelial cell plasma membrane. To our knowledge, this is the first report of a synergistic action of a non toxic PLA2 in enhancing the detachment of endothelial cells induced by a metalloproteinase.","palabras_clave":"METALLOPROTEINASE|PHOSPHOLIPASE A2|ENDOTHELIAL CELLS|SYNERGISM|SNAKE VENOM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19079,"idioma_id":5,"titulo":"Ingeniería inversa en el contexto de ADM","resumen":"El proceso de analizar los artefactos de sistemas de software existentes para extraer información y proveer vistas de alto nivel del sistema (ingeniería inversa) es unaetapa crucial de la modernización de software. La iniciativa Architecture?Driven Modernization (ADM) fue propuesta por OMG (Object Management Group) con elobjetivo de definir estándares para soportar el proceso de modernización en el contexto de desarrollos dirigidos por modelos. Dentro de los estándares se definieron metamodelos relevantes para la ingeniería inversa tales como Knowledge Discovery Metamodel (KDM) y Abstract Syntax Tree Metamodel (ASTM). Se propone en este trabajo aplicar los principios de ADM para proveer vistas de alto nivel de sistemas heredados. Se describe un framework para la ingeniería inversa de código orientado a objetos a fin de extraer modelos UML. Se ejemplifica la propuesta con un caso de estudio que muestra cómo recuperar diagramas de casos de uso y de interacción a partir de código Java. La propuesta fue validada utilizando el framework de modelado Eclipse y la plataforma MoDisco que puede considerarse como laimplementación oficial de los estándares ADM.","palabras_clave":"MODERNIZACION DE SOFTWARE|ADM|MDA|REVERSE ENGINEERING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19080,"idioma_id":4,"titulo":"Influence of vascular endothelial growth factor and Cysteamine on in vitro bovine oocyte maturation and subsequent embryo development","resumen":"The objective of this study was to investigate the effect of VEGF and Cysteamine during in vitro maturation (IVM) of bovine oocytes on GSH content and developmental competence. For this purpose, experiments were designed to evaluate the effect of 0, 100, 300, and 500 ng\/mL VEGF in IVM medium on: GSH content in oocytes and cumulus cells (Exp. 1) and subsequent embryo development (Exp. 2). Also, influence of adding 500 ng\/mL VEGF and 100 mMCysteamine to IVM medium on GSH content in oocytes and cumulus cells (Exp. 3) and oocyte developmental capacity (Exp. 4) were evaluated. Oocytes were matured in: a) Control; b) VEGF 0?3 h; c) Cysteamine 4?24 h; d) VEGF 0?3hþCysteamine 4?24 h; and e)VEGFþCysteamine 24 h. The results showed that: i) VEGF did not alter GSH content in oocytes and cumulus cells; (ii) supplementation of 300 and 500 ng\/mL VEGF increased blastocyst yield; (iii) the presence of VEGF + Cysteamine simultaneously during 24 h improved GSH content but not embryo development; and (iv) the presence of VEGF during the first 3 hþCysteamine from 4 to 24 h increased GSH concentrations and subsequent embryo development. In conclusion, the addition of VEGF and Cysteamine in two sequential steps to maturation medium result in an improvement of cytoplasmic maturation, with a positive impact on oocyte developmental capacity by increasing the efficiency of in vitro blastocyst production. However, the effect was detrimental when both VEGF and Cysteamine were present during 24 of IVm.","palabras_clave":"BLASTOCYST|BOVINE|EMBRYO DEVELOPMENT|VASCULAR ENDOTHELIAL GROWTH FACTOR|GLUTATHIONE|OOCYTE MATURATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19081,"idioma_id":4,"titulo":"An inexact restoration derivative-free filter method for nonlinear programming","resumen":"An inexact restoration derivative-free filter method for nonlinear programming is introduced in this paper. Each iteration is composed of a restoration phase, which reduces a measure of infeasibility, and an optimization phase, which reduces the objective function. The restoration phase is solved using a derivative-free method for solving underdetermined nonlinear systems with bound constraints, developed previously by the authors. An alternative for solving the optimization phase is considered. Theoretical convergence results and some preliminary numerical experiments are presented.","palabras_clave":"Derivative-free|Nonlinear programming |Filter method|Inexact restoration methods"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19082,"idioma_id":4,"titulo":"Nuclear localization of MUC1 extracellular domain in breast, head and neck, and colon cancer","resumen":"BACKGROUND:The glycoprotein MUC1 is overexpressed and underglycosylated in cancer cells. MUC1 is translated as a single polypeptide that undergoes autocleavage into 2 subunits (the extracellular domain and the cytoplasmic tail), and forms a stable heterodimer at the apical membrane of normal epithelial cells. The MUC1 cytoplasmic tail localizes to the cytoplasm of transformed cells and is targeted to the nucleus.AIMS:To study the expression of the MUC1 extracellular subunit in cell nuclei of neoplastic breast, head and neck, and colon samples.MATERIALS AND METHODS:330 primary tumor samples were analyzed: 166 invasive breast carcinomas, 127 head and neck tumors, and 47 colon tumors; 10 benign breast disease (BBD) and 40 normal specimens were also included. A standard immunohistochemical method with antigen retrieval was performed. Nuclear fractions from tissue homogenates and breast cancer cell lines (ZR-75, MDA-MB-231, MCF7, and T47D) were obtained and analyzed by Western blotting (WB). The anti-MUC1 extracellular subunit monoclonal antibody HMFG1 was used for immunohistochemistry.RESULTS:37\/166 breast cancer specimens, 5\/127 head and neck cancer specimens, 2\/47 colon cancer samples, and 3\/10 BBD samples showed immunohistochemical staining at the nuclear level. No nuclear reaction was detected in normal samples. By WB, breast and colon cancer purified nuclear fractions showed reactivity at 200 kDa in 3\/30 breast and 3\/20 colon cancer samples as well as purified nuclear fractions obtained from breast cancer cell lines.CONCLUSIONS:This study shows that the MUC1 extracellular domain might be translocated to the cell nucleus in breast, head and neck, and colon cancer as well as BBD","palabras_clave":"MUC1-N|Cáncer|Expresión nuclear"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19083,"idioma_id":5,"titulo":"Características estructurales y fisiológicas de Petunia axillaris relacionadas con su baja sensibilidad a glifosato","resumen":"La utilización repetida de glifosato como herbicida, entre otros aspectos, aumenta la frecuencia de individuos con baja sensibilidad al mismo. Entre los numerosos casos reportados de especies de malezas que han presentado algún inconveniente para su adecuado manejo se encuentra Petunia axillaris. En este trabajo se evalúa su sensibilidad y se estudian posibles mecanismos involucrados. Se analizó la retención, absorción y translocación con herbicida radiomarcado, así como también la modificación estructural producida por la aplicación del herbicida. Los análisis comprueban que Petunia axillaris es una especie tolerante a glifosato, no mostrando inhibición de la ruta metabólica del ácido shikímico. La menor sensibilidad al herbicida podría estar relacionada con una menor retención foliar de glifosato y un mayor tiempo de absorción; lo cual retarda el ingreso y movimiento del herbicida. Desde el punto de vista estructural se afecta el desarrollo del eje principal, mateniendo sin embargo una elevada producción de flores y semillas. Petunia axillaris muestra una combinación de características morfológicas-estructurales y fisiológicas que determinan su ventaja adaptativa para permanecer y aumentar su población en sistemas con uso intensivo de glifosato.","palabras_clave":"malezas, | tolerancia,|forma de crecimiento| capacidad reproductiva"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19084,"idioma_id":4,"titulo":"Impact of pollination on sunflower yield: is pollen amount or pollen quality what matters?","resumen":"tLocal and international information on sunflower pollination indicate that crop yield may be limited bythe quality of the pollination service. This work focuses on the response of commercially-grown sunflowerhybrids to variations in the amount and quality of the pollen delivered to stigmas, measured in termsof grain set, unit grain weight, grain oil concentration, and oil yield per plant as a way to assess theimportance of entomophilous pollination for this crop. Three consecutive experiments including 2?8experimental treatments each were conducted between 2004 and 2007 in Argentina. The results (a)demonstrate for the first time that the pollen amount and pollen quality that arrive to the stigma havea joint effect on sunflower grain set, (b) suggest that some yield crop components could be sensitive tothis joint effect, and (c) remark the probable positive effect of the pollen redistribution across the head.Overall, results underline the importance of pollinators for the crop, and point out to possible mechanismsthat explain their beneficial effect.","palabras_clave":"sunflower|reproduction"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19085,"idioma_id":4,"titulo":"Assessment of the level of damage to the genetic  material of children exposed to pesticides in the  province of Córdoba","resumen":"Introduction. In the past decades, several authorshave investigated the genotoxicity caused byexposure to chemicals, but there are no reportson studies analyzing such effects on childrenin Argentina. The objective of this study wasto establish the micronucleus frequency inexfoliated buccal mucosa cells in children fromurban areas with environmental exposure(through inhalation) and to compare it with themicronucleus frequency in children from urbanregions far from areas subjected to spraying.Population and Methods. Fifty children living inthe town of Marcos Juárez (Córdoba) at differentdistances from pesticide spraying areas andtwenty-five children from the city of Río Cuarto(Córdoba), who are considered not exposed topesticides, were studied; the micronucleus assayin buccal mucosa cells was used.Results. A significant difference was observedbetween exposed children living less than 500 mfrom areas subjected to spraying and those whowere not exposed. Forty percent of exposedchildren suffer some type of persistent condition,which may be associated with chronic exposureto pesticides.Conclusions. Results indicate that genotoxicityis present in a group of children compared tothe other one, and highlight the importance ofthe micronucleus assay in buccal mucosa cellsfor genetic biomonitoring and public healthsurveillance. This assay is capable of detectinga level of damage that can be reversible.Key words: micronuclei, genotoxic induction, buccalmucosa, pesticide exposure, monitoring.","palabras_clave":"BIOMONITOREO|GENOTOXICIDAD|PLAGUICIDAS|NIÑOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19086,"idioma_id":4,"titulo":"SPATIOTEMPORAL TRENDS OF CASES OF INFLUENZA A H1N1 PANDEMIC IN ARGENTINA, 2009-2012","resumen":"The aim of this paper was to analyze the spatiotemporal variations of cases of influenza A (H1N1) pandemic in Argentina. A space-time permutation scan statistic was performed to test the non-randomness in the interaction between space and time in reported influenza A (H1N1) cases. In 2009, two clusters were recorded in the east of Buenos Aires province (May and June) and most central and northern Argentina (July and August). During 2011 and 2012 clusters near areas bordering other countries were recorded. Within the clusters, in 2009 first high notification rates were observed in school-age population and then extended to older population (15-59 years). From 2011 onwards, higher rates of reported cases of influenza H1N1 occurred in children under 5 years in center of the country. We could characterize two-stage spatio-temporal transmission of influenza A H1N1. The first stage with high rates of notification and a possible interaction with individuals from other countries through the major cities of Argentina (pattern of hierarchy). The second stage showed increased interaction in some border areas without a clear pattern of hierarchy.  These results suggest the need for greater co-ordination in the Southern Cone countries, in order to implement joint prevention and vaccination policies.Key words: Influenza A virus, cluster analysis, spatio-temporal analysis, Argentina.","palabras_clave":"PANDEMIA|GEOREFERENCIAMIENTO|EPIDEMIOLOGIA|INFLUENZA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19087,"idioma_id":4,"titulo":"A method to estimate missing AERONET AOD values based on artificial neural networks","resumen":"In this work, we present a method to predict missing aerosol optical depth (AOD) values at an AERONET station. The aim of the method is to fill gaps and\/or to extrapolate temporal series in the station datasets, i.e. to obtain AOD values under cloudy sky conditions and in other situations where there is a temporary or permanent lack of data. To accomplish that, we used historical AOD values at two stations, air mass trajectories passing through both of them (calculated by using the HYSPLIT model) and ANN calculations to process all the information. The variables included in the neural network training were the station numbers, parameters representing the annual average trend of meteorological conditions, the number of hours and the distance traveled by the air mass between the stations, and the arrival height of the air mass. The method was firstly applied to predict AOD at 440nm in 9 stations located in the East Coast of the US, during the years 1999-2012. The coefficient of determination r2 between measured and calculated AOD values was 0.855, which show the good performance of the method. Besides, this result represents a remarkable improvement compared to three simple approaches. To further validate the method, we applied it to another region (Iberian Peninsula) with different characteristics (lower density of AERONET stations, different meteorology, and lower wind field spatial resolution). Although the results are still good (r2=0.67), the performance of the method was affected by these characteristics. Considering the obtained results, this method can be used as a powerful tool to predict AOD values in several conditions. The methodology can also be easily adapted to predict AOD values at other wavelengths or other aerosol optical properties.","palabras_clave":"AOD PREDICTION|EASTERN US REGION|IBERIAN PENINSULA REGION|HYSPLIT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19088,"idioma_id":4,"titulo":"Towards high-throughput immunomics for infectious diseases:      use of next-generation peptide microarrays for rapid discovery and mapping of antigenic determinants","resumen":"Complete characterization of antibody specificities   associated to natural infections is expected to provide a rich source of   serologic biomarkers with potential applications in molecular   diagnosis, follow-up of chemotherapeutic treatments, and prioritization   of targets for vaccine development. Here, we developed a   highly-multiplexed platform based on next-generation high-density   peptide microarrays to map these specificities in Chagas Disease, an   exemplar of a human infectious disease caused by the protozoan   Trypanosoma cruzi. We designed a high-density peptide microarray   containing more than 175,000 overlapping 15mer peptides derived from T.   cruzi proteins. Peptides were synthesized in situ on microarray slides,   spanning the complete length of 457 parasite proteins with fully   overlapped 15mers (1 residue shift). Screening of these slides with   antibodies purified from infected patients and healthy donors   demonstrated both a high technical reproducibility as well as epitope   mapping consistency when compared with earlier low-throughput   technologies. Using a conservative signal threshold to classify positive   (reactive) peptides we identified 2,031 disease-specific peptides and   97 novel parasite antigens, effectively doubling the number of known   antigens and providing a tenfold increase in the number of fine mapped   antigenic determinants for this disease. Finally, further analysis of   the chip data showed that optimizing the amount of sequence overlap of   displayed peptides can increase the protein space covered in a single   chip by at least ~3 fold without sacrificing sensitivity. In conclusion,   we show the power of high-density peptide chips for the discovery of   pathogen-specific linear B-cell epitopes from clinical samples, thus   setting the stage for high-throughput biomarker discovery screenings and   proteome-wide studies of immune responses against pathogens.","palabras_clave":"Infectious diseases|B-cell epitope|Chagas disease|peptide chip"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19089,"idioma_id":5,"titulo":"Patología en una vivienda unifamiliar de tres plantas construída sobre una ladera","resumen":"El empleo de óptimos materiales de construcción si nos es acompañado de una eficiente supervisión , puede conducir a patalogías importantes en las construcciones.Ese es el caso de una vivienda unifamiliar construída en tres plantas sobre un faldeo compuesto por una secuencia de lutitas y areniscas. Apoyada en terreno natural la vivienda poseía un contrapiso en una de sus plantas, el mismo requirió el empleo de material de relleno. La mala supervisión trajo como consecuencia la rotura de varios elementos construcctivos.","palabras_clave":"patología|material de relleno|supervisión"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19090,"idioma_id":4,"titulo":"Pathogenic interaction between Escovopsis weberii and Leucoagaricus sp: Mechanism involved and virulence levels","resumen":"Attini are the only ants that use freshplant material to cultivate species of Leucoagaricus,which are their source of nutrition. Escovopsisspecies are specialized mycoparasites of Leucoagaricus sp.and Escovopsis parasitism has anegative impact on the health of the ants' colonies. The goals of this workwere: to test if the virulence of different isolates of Escovopsis weberi were the sameacross Leucoagaricus sp. and to analyze ifstructural mechanisms were related to variation in the virulence of E. weberi isolates. All E. weberi isolates were able toparasitize isolates of Leucoagaricusspp. but with striking differences in virulence, and it was shown that thecontact between hyphae of both fungi was the main process that generates thedegradation of Leucoagaricus isolates.Additionally, the two most virulent isolates produced hook-like protuberances,increasing the damage caused to its target. Finally, E. weberi was re-classified as adestructive biotrophic parasite.","palabras_clave":"Ascomycota|Hooks|Leaf-cutters ants|Mycoparasitism"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19091,"idioma_id":4,"titulo":"Identifying Genetic Hotspots by Mapping Molecular Diversity of Widespread Trees: When Commonness Matters","resumen":"Conservation planning requires setting priorities at the same spatial scale at which decision-making processes are undertaken considering all levels of biodiversity, but current methods for identifying biodiversity hotspots ignore its genetic component. We developed a fine-scale approach based on the definition of genetic hotspots, which have high genetic diversity and unique variants that represent their evolutionary potential and evolutionary novelties. Our hypothesis is that wideranging taxa with similar ecological tolerances, yet of phylogenetically independent lineages, have been and currently are shaped by ecological and evolutionary forces that result in geographically concordant genetic patterns. We mapped previously published genetic diversity and uniquevariants of biparentally inherited markers and chloroplast sequences for 9 species from 188 and 275 populations, respectively, of the 4 woody dominant families of the austral temperate forest, an area considered a biodiversity hotspot. Spatial distribution patterns of genetic polymorphisms differed among taxa according to their ecological tolerances. Eight genetic hotspots were detected and we recommend conservation actions for some in the southern Coastal Range in Chile. Existing spatially explicit genetic data from multiple populations and species can help to identify biodiversity hotspots and guide conservation actions to establish science-based protected areas that will preserve the evolutionary potential of key habitats and species.","palabras_clave":"AUSTRAL FORESTS|GENETIC DIVERSITY|HAPLOTYPE DIVERSITY|PATAGONIA|UNIQUE ALLELES|UNIQUE HAPLOTYPES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19092,"idioma_id":5,"titulo":"?Las organizaciones empresariales en la era de los agronegocios: una caracterización de AAPRESID y AACREA","resumen":"En el presente artículo realizamos una caracterización de las dos entidades técnicas más representativas del sector agropecuario argentino: AAPRESID y AACREA. Visibilizamos los elementos comunes que las definen, y aquellos que las diferencian en su función, sus vinculaciones institucionales y su trama organizativa. A su vez, a  través del análisis de sus discursos, vislumbramos la convergencia de ambas entidades en un conjunto de  ideas comunes sobre el estado, la naturaleza, la tecnología y la sociedad. A partir de este recorrido concluimos analizando  la ampliación del perfil y los terrenos de intervención de estas entidades que evolucionan de ser organizaciones técnicas a referentes políticos e ideológicos para amplios sectores del mundo agrario.","palabras_clave":"entidades tecnicas|agronegocios|ideología|aparatos ideológicos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19093,"idioma_id":4,"titulo":"Structural flexibility of the heme cavity in the cold-adapted truncated hemoglobin from the Antarctic marine bacterium Pseudoalteromonas haloplanktis TAC125","resumen":"Truncated hemoglobins build one of the three branches of the globin protein superfamily. They display a characteristic two-on-two &#945;-helical sandwich fold and are clustered into three groups (I, II and III) based on distinct structural features. Truncated hemoglobins are present in eubacteria, cyanobacteria, protozoa and plants. Here we present a structural, spectroscopic and molecular dynamics characterization of a group-II truncated hemoglobin, encoded by the PSHAa0030 gene from Pseudoalteromonas&nbsp;haloplanktis TAC125 (Ph-2\/2HbO), a cold-adapted Antarctic marine bacterium hosting one flavohemoglobin and three distinct truncated hemoglobins. The Ph-2\/2HbO aquo-met crystal structure (at 2.21 Å resolution) shows typical features of group-II truncated hemoglobins, namely the two-on-two &#945;-helical sandwich fold, a helix &#934; preceding the proximal helix F, and a heme distal-site hydrogen-bonded network that includes water molecules and several distal-site residues, including His(58)CD1. Analysis of Ph-2\/2HbO by electron paramagnetic resonance, resonance Raman and electronic absorption spectra, under varied solution conditions, shows that Ph-2\/2HbO can access diverse heme ligation states. Among these, detection of a low-spin heme hexa-coordinated species suggests that residue Tyr(42)B10 can undergo large conformational changes in order to act as the sixth heme-Fe ligand. Altogether, the results show that Ph-2\/2HbO maintains the general structural features of group-II truncated hemoglobins but displays enhanced conformational flexibility in the proximity of the heme cavity, a property probably related to the functional challenges, such as low temperature, high O2 concentration and low kinetic energy of molecules, experienced by organisms living in the Antarctic environment.","palabras_clave":"haloplanktis|extreme environment|hemeprotein"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19094,"idioma_id":5,"titulo":"LA COMUNIDAD EDUCATIVA ANTE EL DESAFIO DE INCLUSIÓN EN EL MARCO DE LAS POLÍTICAS EDUCATIVAS Y SOCIALES Y LAS EXPECTATIVAS DE LAS FAMILIAS","resumen":"El presente artículo es el resultado de la articulación del producto de dos investigaciones llevadas a cabo entre los años 2009-2010 y 2011-2013 en la ciudad de Posadas Misiones   En la primer investigación ?Análisis de los efectos de la aplicación de programas compensatorios en las instituciones educativas de Posadas y en las condiciones laborales docentes. Período 2005-2010 se registraron las diferentes representaciones que directivos y docentes tenían acerca de los sujetos de aprendizaje y sus familias lo que motivó a efectuar la segunda investigación ?Importancia que le asignan las familias en condición de pobreza a la educación?, a los efectos de obtener la mirada de las familias en relación a la escuela, docentes y directivos, así como sobre los planes sociales.","palabras_clave":"Representaciones sociales |Educación |Familia |Escuela"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19095,"idioma_id":4,"titulo":"rDNA loci and heterochromatin positions support a distinct genome type for 'x=9 species' of section Arachis (Arachis, Leguminosae)","resumen":"Most species of the genus Arachis (Leguminosae; 80 spp.) are diploid with x=10 and only four species have x=9 chromosomes. Three of these x=9 species belong to section Arachis and are morphologically and chromosomally similar. To study the homeology of the genomes of x=9 species and their relation to other genomes in section Arachis we applied fluorescence in situ hybridization (FISH) of 18S-26S and 5S rDNA and 4´, 6-diamidino-2-phenylindole (DAPI) banding. FISH revealed for these  three species one pair of 5S rDNA sites interstitially within the short arm of the metacentric pair 6 and one pair of 18S-26S rDNA sites in the proximal region of the long arm of the SAT chromosomes. Conspicuous DAPI+ bands were detected pericentromerically in all nine chromosome pairs of A. decora and A. praecox and in all but one pair of A. palustris. Our results suggest that all three species with x=9 of section Arachis share the same genome type and are different from the other genome  types A, B, D, F, and K described for this section. Apparently, the x=9 species of section Arachis form a monophyletic group characterized by a genome type that we propose to call G genome.","palabras_clave":"ARACHIS X=9|FISH|CHROMOSOMES|rDNA sites"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19096,"idioma_id":4,"titulo":"Microplankton dynamics under heavy anthropogenic pressure. The case of the Bahía Blanca Estuary, southwestern Atlantic Ocean","resumen":"Quantifying biotic feedbacks in response to environmental signals is fundamental to assess ecosystem perturbation. We analyzed the joint effects of eutrophication, derived from sewage pollution, and climate at the base of the pelagic food web in the Bahía Blanca Estuary (SW Atlantic Ocean). A two-year survey of environmental conditions and microplankton communities was conducted in two sites affected by contrasting anthropogenic eutrophication conditions. Under severe eutrophication, we found higher phytoplankton abundance consistently dominated by smaller sized, non siliceous species, while microzooplankton abundance remained lower and nutrient stoichiometry showed conspicuous deviations from the Redfield ratio. Phytoplankton growth in such conditions appeared controlled by phosphorous. In turn, microplankton biomass and phytoplankton size ratio (20µm) displayed a saturation relationship with nutrients in the highly eutrophic area, although mean phytoplankton growth was similar in both eutrophic systems. The strength of links within the estuarine network, quantified through path analysis, showed enhanced relationships under larger anthropogenic eutrophication, which fostered the climate influence on microplankton communities. Our results show conspicuous effects of severe sewage pollution on the ecological stoichiometry, i.e., N and P excess with respect to Si, altering nutrient ratios for microplankton communities. This warns on wide consequences on food web dynamics and ultimately in ecosystem assets of coastal pelagic environments.","palabras_clave":"MICROPLANKTON|EUTROPHICATION|ESTUARIES|NUTRIENT STOICHIOMETRY|CLIMATE|PATH ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19097,"idioma_id":4,"titulo":"Altimeter-derived seasonal circulation on the southwest Atlantic shelf: 27°?43°S","resumen":"Altimeter sea surface height (SSH) fields are analyzed to define and discuss the seasonal circulationover the wide continental shelf in the SW Atlantic Ocean (278?438S) during 2001?2012. Seasonal variabilityis low south of the Rio de la Plata (RdlP), where winds and currents remain equatorward for most ofthe year. Winds and currents in the central and northern parts of our domain are also equatorward duringautumn and winter but reverse to become poleward during spring and summer. Transports of shelf waterto the deep ocean are strongest during summer offshore and to the southeast of the RdlP. Details of theflow are discussed using mean monthly seasonal cycles of winds, heights, and currents, along with analysesof Empirical Orthogonal Functions. Principle Estimator Patterns bring out the patterns of wind forcing andocean response. The largest part of the seasonal variability in SSH signals is due to changes in the wind forcing(described above) and changes in the strong boundary currents that flow along the eastern boundaryof the shelf. The rest of the variability contains a smaller component due to heating and expansion of thewater column, concentrated in the southern part of the region next to the coast. Our results compare wellto previous studies using in situ data and to results from realistic numerical models of the regionalcirculation.","palabras_clave":"COASTAL PROCESSES|DIURNAL, SEASONAL AND ANNUAL CYCLES|WESTERN BOUNDARY CURRENTS|VARIATIONS AND MEAN|INSTRUMENTS AND TECHNIQUES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19098,"idioma_id":4,"titulo":"Stability, Redox Parameters and Electrocatalytic Activity of a Cytochrome Domain from a New Subfamily","resumen":"We report a spectroscopic, electrochemical and spectroelectrochemical characterization of the soluble cytochrome c domain (Cyt-D) from the Rhodothermus marinus caa3 terminal oxygen reductase and its putative electron donor, a high potential [4Fe?4S] protein (HiPIP). Cyt-D exhibits superior stability, particularly at the level of the heme pocket, compared to archetypical cytochromes in terms of thermal and chemical denaturation, alkaline transition and oxidative bleaching of the heme, which is further increased upon adsorption on biomimetic electrodes. Therefore, this protein is proposed as a suitable building block for electrochemical biosensing. As a proof of concept, we show that the immobilized Cyt-D exhibits good electrocatalytic activity towards H2O2 reduction. Relevant thermodynamic and kinetic electron transfer parameters for Cyt-D and HiPIP are also reported, including reorganization energies of 0.33 eV and 0.42 eV, respectively.","palabras_clave":"Heme proteins|Iron-sulfur proteins|Protein electron transfer|Hydrogen peroxide sensing|SERR spectroelectrochemistry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19099,"idioma_id":4,"titulo":"Simultaneous biodegradation of bisphenol a and a biogenic substrate in semi-continuous activated sludge reactors","resumen":"In this work, the simultaneous degradation of BPA and cheese whey (CW) in semi-continuousactivated sludge reactors was studied. The acclimation process and microbial growth on BPA, CW and BPA and CW were analyzed. In addition, the effect of increasing CW concentration on the BPA degradation by acclimated activated sludge was also studied. Inorder to reduce the factors involved in the analysis of the simultaneous degradation of BPA and CW, the effect of bisphenol A (BPA) on activated sludge not previously exposed to BPA (native activated sludge) was studied. Results demonstrate that BPA concentrationslower than 40 mg l-1 had a negligible effect on the growth of native activated sludge. In the semicontinuous reactors, the presence of CW increased the acclimation time to 40 mg l-1 of BPA. Once the capability of degrading BPA was acquired, the removal of BPA was not affected by the presence of CW. Increasing the CW concentration did not affectthe removal of BPA by the acclimated activated sludge. Additionally, the CW consumption was not modified by the presence of BPA. Kinetic and stoichiometric coefficients reported in the present work can be useful in developing mathematical models to describe the simultaneous aerobic biodegradation of a biogenic substrate, such as CW, and BPAby activated sludge","palabras_clave":"Bisphenol A|Activated sludge|Acclimation|Growth yield"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19100,"idioma_id":5,"titulo":"Mitos y verdades acerca de los mosquitos","resumen":"Se describe la importancia de los mosquitos como vectores de enfermedades, las especies de ambientes urbanos, en particular de la ciudad de Rosario, y se discute la validez de las principales creencias populares acerca de estos insectos.","palabras_clave":"Mosquitos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19101,"idioma_id":4,"titulo":"Grazing increases below-ground biomass and net primary production in a temperate grassland","resumen":"Grazing can affect the stock and flow of C between above and below-ground vegetation layers. Components of below-ground stratum are one of the less studied. The goals of this research were: 1) to characterize and estimate the vertical distribution of below-ground biomass in grazed and ungrazed areas during a growing season, and 2) to evaluate grazing effects on below-ground net primary production (BNPP). Below-ground biomass was cored four times to 100 cm depth during a growing season on three paired grazed-ungrazed areas in South-central Uruguayan grasslands. BNPP was estimated using both field data and CENTURY model. On average, below-ground biomass was higher in grazed (1417 g\/m2) than in ungrazed areas (945 g\/m2) and showed a marked reduction in relation with soil depth. Turnover rates were 0.40 and 0.37 years in grazed and ungrazed areas respectively. Field data and CENTURY simulation showed higher BNPP in grazed areas (1.86; 0.77 g\/m2.day respectively) than in ungrazed areas (1.07; 0.67 g\/m2.day respectively). Grazed areas showed higher below-ground biomass, BNPP and turnover that ungrazed areas. Grazing has an important role in regulating both stock and dynamics of C in grassland ecosystems.","palabras_clave":"roots|biomass"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19102,"idioma_id":4,"titulo":"Platelets interact with Coxsackieviruses B and have a critical role in the pathogenesis of virus-induced myocarditis","resumen":"To further understand the role of platelets in the pathogenesis of viral infections we explored platelet interaction with Coxsackieviruses B (CVB) 1 and 3. CVB is a group of viruses that cause the majority of human enterovirus-related viral myocarditis; their receptor (CAR) is expressed on the platelet surface and there is a well-characterized CVB3-induced myocarditis murine model.    METHODS:  Human platelets were infected with CVB1 and 3 and viruses were detected in pellets and in supernatants. C57BL\/6J mice with or without platelet depletion were inoculated with CVB3 and peripheral blood and heart samples collected at different times post-infection.    RESULTS:  CVB1 and 3 RNA and a capsid protein were detected in infected platelets. Despite the fact that titration assays in Vero cells showed increasing infectivity titers over time, supernatants and pellets from infected platelets showed similar levels, suggesting that platelets were not susceptible to a replicative infectivity cycle. CVB binding was CAR-independent and resulted in P-selectin and phosphatidylserine (PS) exposure. CVB3-infected mice showed a rapid thrombocytopenia that correlated with an increase in platelet PS exposure and platelet-leukocyte aggregates without modification of platelet P-selectin expression or von Willebrand factor levels. Mortality, viremia, heart viral titers and myocarditis were significantly higher in platelet-depleted than normal animals. Type I IFN levels were not changed but IgG levels were lower in infected and platelet-depleted mice.    CONCLUSIONS:  Our data reveal that platelets play a critical role in host survival and immune response against CVB3 infection.","palabras_clave":"Human-enterovirus B|pathogenesis|platelets|thrombocytopenia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19103,"idioma_id":4,"titulo":"Myoepithelial and luminal breast cancer cells exhibit different responses to all-trans retinoic acid","resumen":"Purpose: Breast cancer is the leading cause of death among women worldwide. The exact role of luminal epithelial (LEP) and myoephitelial (MEP) cells in breast cancer development is as yet unclear, as also how retinoids may affect their behaviour. Here, we set out to evaluate whether retinoids may differentially regulate cell type-specific processes associated with breast cancer development using the bi-cellular LM38-LP murine mammary adenocarcinoma cell line as a model.   Materials and methods: The bi-cellular LM38-LP murine mammary cell line was used as a model throughout all experiments. LEP and MEP subpopulations were separated using inmunobeads, and the expression of genes known to be involved in epithelial to mysenchymal transition (EMT) was assessed by qPCR after all-trans retinoic acid (ATRA) treatment. In vitro invasive capacities of LM38-LP cells were evaluated using 3D Matrigel cultures in conjunction with confocal microscopy. Also, in vitro proliferation, senescence and apoptosis characteristics were evaluated in the LEP and MEP subpopulations after ATRA treatment, as well as the effects of ATRA treatment on the clonogenic, adhesive and invasive capacities of these cells. Mammosphere assays were performed to detect stem cell subpopulations. Finally, the orthotopic growth and metastatic abilities of LM38-LP monolayer and mammosphere-derived cells were evaluated in vivo.  Results: We found that ATRA treatment modulates a set of genes related to EMT, resulting in distinct gene expression signatures for the LEP or MEP subpopulations. We found that the MEP subpopulation responds to ATRA by increasing its adhesion to extracellular matrix (ECM) components and by reducing its invasive capacity. We also found that ATRA induces apoptosis in LEP cells, whereas the MEP compartment responded with senescence. In addition, we found that ATRA treatment results in smaller and more organized LM38-LP colonies in Matrigel. Finally, we identified a third subpopulation within the LM38-LP cell line with stem\/progenitor cell characteristics, exhibiting a partial resistance to ATRA.  Conclusions: Our results show that the luminal epithelial (LEP) and myoephitelial (MEP) mammary LM38-P subpopulations respond differently to ATRA, i.e., the LEP subpopulation responds with increased cell cycle arrest and apoptosis and the MEP subpopulation responds with increased senescence and adhesion, thereby decreasing its invasive capacity. Finally, we identified a third subpopulation with stem\/progenitor cell characteristics within the LM38-LP mammary adenocarcinoma cell line, which appears to be non-responsive to ATRA.","palabras_clave":"MYOEPITHELIAL CELLS|LUMINAL CELLS|BREAST CANCER|ATRA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19104,"idioma_id":5,"titulo":"Evaluación por competencias en EVA","resumen":"En el presente trabajo se referencian las principales competencias desarrolladas en los EVA","palabras_clave":"COMPETENCIAS|EVALUACION|TIC|ENTORNOS VIRTUALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19105,"idioma_id":5,"titulo":"El Conocimiento como  relación y la relación con el conocimiento en la formación universitaria de grado: Nuevas tendencias y nuevos desafíos","resumen":"El trabajo gira alrededor de la pregunta sobre las concepciones que circulan al interior de la vida universitaria en lo que respecta a la producción y transmisión de información y conocimientos en relación con la formación profesional de grado, indagando las posturas de los actores centrales involucrados en este campo problemático con el objetivo de complejizar y enriquecer las refexiones sobre los nuevos desafíos que la UNTREF enfrenta en este siglo. Particularmente se concentran en las exigencias de producción de conocimiento y su condicionamiento mercantilista y en las demandas cambiantes del mercado laboral en un nuevo contexto productivo que promueven una formación meramente técnica que garantice rápidamente las condiciones mínimas de acreditación requeridas para acceder a un puesto laboral determinado.   La investigación busca generar un aporte pedagógico, instrumental, para la mejora de la práctica áulica y el abordaje de los desafíos que enfrenta la educación superior.","palabras_clave":"Conocimiento como relación|Estudiantes|Sociedad de consumo|Docentes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19106,"idioma_id":4,"titulo":"In Plane Vortex Dynamic Anisotropy in the Iron Deficient Fe1-ySe Superconductor","resumen":"PROCEEDINGS OF ADVANCED TOPICS IN MAGNETISM AND SUPERCONDUCTIVITY (AToMS-2014): We present electrical transport measurements in the superconducting dissipative state of crystalline iron deficient FeFe1-ySe samples. These iron deficient samples were synthesized using NaCl\/KCl flux and are characterized by the presence of correlated defects. The dissipation in electrical transport experiments, when the driving current is perpendicular or parallel to the crystal planes, depends strongly on the direction of the applied magnetic field , (H=12 T), within the sample plane. There is a dissipation modulation each 60&#8728; due to the presence of the correlated defects. We correlate these angular dependent features with the variation of the critical currents (Jc) changing the direction of H confined in the crystals planes. Jc was measured from magnetization loops at fixed temperatures and angles of H always within the basal planes.","palabras_clave":"IRON-BASED SUPERCONDUCTORS|ELECTRICAL TRANSPORT|CRITICAL CURRENTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19107,"idioma_id":4,"titulo":"Optimization of fermentation parameters to study the behavior of selected lactic cultures on soy solid state fermentation","resumen":"The use of solid fermentation substrate (SSF) has been appreciated by the demand for natural and healthy products. Lactic acid bacteria and bifidobacteria play a leading role in the production of novel functional foods and their behavior is practically unknown in these systems. Soy is an excellent substrate for the production of functional foods for their low cost and nutritional value. The aim of this work was to optimize different parameters involved in solid state fermentation (SSF) using selected lactic cultures to improve soybean substrate as a possible strategy for the elaboration of new soy food with enhanced functional and nutritional properties. Soy flour and selected lactic cultures were used under different conditions to optimize the soy SSF. The measuredresponses were bacterial growth, free amino acids and &#946;-glucosidase activity, which were analyzed by applying response surface methodology. Based on the proposed statistical model, different fermentation conditions were raised by varying the moisture content (50?80%) of the soy substrate and temperature of incubation (31?43 °C).The effect of inoculum amount was also investigated. These studies demonstrated the ability of selected strains (Lactobacillus paracasei subsp. paracasei and Bifidobacterium longum) to grow with strain-dependent behavior on the SSF system. &#946;-Glucosidase activity was evident in both strains and L. paracasei subsp. paracasei was ableto increase the free amino acids at the end of fermentation under assayed conditions. The used statistical model has allowed the optimization of fermentation parameters on soy SSF by selected lactic strains. Besides,the possibility towork with lower initial bacterial amounts to obtain resultswith significant technological impact was demonstrated.","palabras_clave":"Solid state fermentation|Soy flour|Lactic cultures|Response surface methodology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19108,"idioma_id":4,"titulo":"Open clusters. II. Fundamental parameters of B stars in Collinder 223, Hogg 16, NGC 2645, NGC 3114, and NGC 6025","resumen":"Context. The knowledge of accurate values of effective temperature, surface gravity, and luminosity of stars in open clusters is very important not only to derive cluster distances and ages but also to discuss the stellar structure and evolution. Unfortunately, stellar parameters are still very scarce.Aims. Our goal is to study five open clusters to derive stellar parameters of the B and Be star population and discuss the cluster properties. In a near future, we intend to gather a statistically relevant samples of Be stars to discuss their origin and evolution.Methods. We use the Barbier-Chalonge-Divan spectrophotometric system, based on the study of low-resolution spectra around the Balmer discontinuity, since it is independent of the interstellar and circumstellar extinction and provides accurate Hertzsprung-Russelldiagrams and stellar parameters.Results. We determine stellar fundamental parameters, such as effective temperatures, surface gravities, spectral types, luminosity classes, absolute and bolometric magnitudes and colour gradient excesses of the stars in the field of Collinder 223, Hogg 16,NGC2645, NGC3114, and NGC6025. Additional information, mainly masses and ages of cluster stellar populations, is obtained using stellar evolution models. In most cases, stellar fundamental parameters have been derived for the first time. We also discuss the derived cluster properties of reddening, age and distance.Conclusions. Collinder 223 cluster parameters are E(B &#8722; V) = 0.25 ± 0.03 mag and (mv &#8722; Mv)0 = 11.21 ± 0.25 mag. In Hogg 16, we clearly distinguish two groups of stars (Hogg 16a and Hogg 16b) with very different mean true distance moduli (8.91 ± 0.26 mag and 12.51 ± 0.38 mag), mean colour excesses (0.26 ± 0.03 mag and 0.63 ± 0.08 mag), and spectral types (B early-type and B late-\/Atype stars, respectively). The farthest group could be merged with Collinder 272. NGC2645 is a young cluster (<14 Myr) with E(B &#8722; V) = 0.58±0.05 mag and (mv &#8722; Mv)0 = 12.18±0.30 mag. The cluster parameters of NGC 3114 are E(B &#8722; V) = 0.10 ± 0.01 mag and (mv &#8722; Mv)0 = 9.20 ± 0.15 mag. This cluster presents an important population of Be star, but it is difficult to define the cluster membership of stars because of the high contamination by field stars or the possible overlapping with a nearby cluster. Finally, we derive the following cluster parameters of NGC6025: E(B &#8722; V) = 0.34 ± 0.02 mag, (mv &#8722; Mv)0 = 9.25 ± 0.17 mag, and an age between 40 Myr and 69 Myr. In all the cases, new Be candidate stars are reported based on the appearance of a second Balmer discontinuity.","palabras_clave":"CLUSTERS|STARS|ASSOCIATIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19109,"idioma_id":4,"titulo":"Stimulation of PAR-1 or PAR-4 promotes similar pattern of  VEGF and endostatin release and pro-angiogenic responses mediated by human platelets","resumen":"Abstract  BACKGROUND:  Platelets mediate angiogenesis through the secretion of several factors, including the pro-angiogenic vascular endothelial growth factor (VEGF) and the anti-angiogenic endostatin. Although previous findings indicated that these molecules are packed into different alpha-granules and selectively released by specific stimulation of protease-activated receptor (PAR)-1 or PAR-4, recent evidences are against this hypothesis.    OBJECTIVES:  To elucidate the controversies about the VEGF and endostatin release and the overall angiogenic effect of PARs-stimulated platelets.    METHODS:  VEGF and endostatin were quantified by enzyme linked-immunosorbent assay (ELISA). Endothelial proliferation (pNPP assay), wound healing (scratch assay) and tubule formation (matrigel) of human microvascular endothelial cells (HMEC-1) and endothelial progenitor cells (EPC) were determined using supernatants from PAR-1- or PAR-4-stimulated platelets.    RESULTS:  Activation of washed platelets (WPs) by PAR-1- or PAR-4-activating peptide (AP) promoted the VEGF and endostatin secretion in a concentration-dependent manner, being PAR-1-AP more potent than PAR-4-AP. The release of both molecules was abrogated by pre-incubation of platelets with PAR antagonists. Activation of platelet-rich plasma (PRP) with either PAR-1-AP or PAR-4-AP induced a significant VEGF secretion. Quantification of platelet-endostatin secretion was not possible in PRP due to the high levels of plasmatic endostatin vs. platelet content. Releasates from PAR-1- or PAR-4-activated WPs promoted similar pattern of angiogenic responses of HMEC-1 or EPC. Moreover, proliferation of HMEC-1 mediated by PAR-stimulated PRP releasates was delayed and significantly lower compared with that induced by PAR-stimulated WPs.    CONCLUSIONS:  Our results are in contrast with the previously described differential release of VEGF and endostatin induced by the selective PAR-1 or PAR-4 stimulation, and support the notion that while circulating endostatin accounts for the maintenance of a systemic anti-angiogenic state, locally, the release of platelet alpha-granule content promotes angiogenesis.","palabras_clave":"Platelets|VEGF|angiogenesis|thrombin"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19110,"idioma_id":4,"titulo":"The effect of mare's age on multiple ovulation rate, embryo recovery, post-transfer pregnancy rate, and interovulatory interval in a commercial embryo transfer program in Argentina","resumen":"Advanced maternal age is an important predisposing factor on the reduction of reproductive efficiency. The aim of this study was to evaluate the effect of donor´s age on several reproductive parameters in a commercial equine embryo transfer program. Donors were classified into 3 age groups: Group 1 = fillies (3 and 4 years old), Group 2 = middle age mares (aged 5-10) and Group 3 = old mares (aged 13-25). Embryo recovery, multiple ovulation and pregnancy rates and interovulatory intervals were compared amongst age groups. Group 1 (171\/244, 70.1%) and Group 2 (774\/1081, 71.6%) had a higher (P  0.05). The interovulatory intervals length was influenced by individual mare (P  0.05), but was shorter than the one of Group 3 (17.4 ± 0.15 days; P < 0.04). The embryo recovery rate of flushings from Groups 1 and 2 was influenced by the length of the previous interovulatory interval (P = 0.03).","palabras_clave":"MARE |AGE|EMBRYO RECOVERY|INTERVAL OVULATION RATE|PREGNANCY RATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19111,"idioma_id":4,"titulo":"Draft Genome Sequence of Halomonas sp. KHS3, a Polyaromatic Hydrocarbon-Chemotactic Strain","resumen":"The draft genome sequence of Halomonas   sp. KHS3, isolated from seawater from Mar del Plata harbor, is   reported. This strain is able to grow using aromatic compounds                       as a carbon source and shows strong chemotactic   response toward these substrates. Genes involved in motility,   chemotaxis,                       and degradation of aromatic hydrocarbons were   identified.","palabras_clave":"GENOME|AROMATIC|DEGRADATION|CHEMOTAXIS|HYDROCARBONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19112,"idioma_id":4,"titulo":"Genome sequence of Bradyrhizobium japonicum E109, one of the most agronomically used nitrogen fixing rhizobacteria in Argentina","resumen":"We present here the complete genome sequence of Bradyrhizobium japonicum strain E109, one of the most used rhizobacteria for soybean inoculation in Argentina since the 1970s. The genome consists of a 9.22-Mbp single chromosome and contains several genes related to nitrogen fixation, phytohormone biosynthesis, and a rhizospheric lifestyle.","palabras_clave":"RHIZOBACTERIA|BRADYRHIZOBIUM|GENOME|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19113,"idioma_id":4,"titulo":"Effects of saliva on early post-tooth extraction tissue repair in rats","resumen":"AbstractThe aim of the present study was to perform a biochemical, histological, and histomorphometrical evaluation of the mechanisms involved in tissue repair in rats subjected to submandibulectomy-induced hyposialia, 24, 48, and 72 hours of post-tooth extraction. We studied the correlation between the lack of submandibular saliva and the modulation of inflammatory mediators involved in tissue repair, such as prostaglandin E2 , nitric oxide (NO), and tumor necrosis factor alpha (TNF-&#945;). Rats with hyposialia showed a delay in socket healing, slow replacement of the clot with granulation tissue, and fewer cells and collagen fibers, concomitant with a longer inflammatory process, as compared to controls. The lack of saliva induced by submandibulectomy modified the levels of prostaglandin E2 , NO, and TNF-&#945;, and tissue response in the early stages of wound healing compared to controls, and could thus determine alterations in later osteogenic response. Our results allow concluding that hyposialia modulates the parameters of inflammation studied here, and that it is essential for optimal healing. Therefore, these findings provide evidence for the importance of submandibular saliva to final bone socket healing.© 2015 by the Wound Healing Society.","palabras_clave":"saliva|glándulas salivales|exodoncia|reparación tisular"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19114,"idioma_id":4,"titulo":"N-Acetylated Gemini Surfactants: Synthesis, Surface-Active Properties, Antifungal Activity, and Ecotoxicity Bioassays","resumen":"A series of N-acetylated cationic gemini surfactants (3a-e) having dimeric structures derived from tertiary amines were synthesized. Their antifungal potency and surface properties were determined. It also studied the acute toxicity of the molecule with the best performance and the best water solubility  (3e) through Chlorella vulgaris and Daphnia magna bioassays. The results were compared to those obtained for a commercially available reference compound 2-(thiocyanomethylthio) benzothiazole (TCMTB). Parameters such as surface tension (&#947;CMC), critical micelle concentration (CMC), surface excess concentration (&#915;), and area per molecule (A) were determined. The resulting values indicated that the five gemini surfactants are characterized by good surface-active and self-aggregation properties. All surfactants were tested to evaluate their antifungal activity. Six fungal strains were used to conduct the study. The minimum inhibitory concentration (MIC) value was measured by the fungal growth inhibition. The results of the MICs were compared with two commercially available reference compounds (Fluconazole and TCMTB). The least active molecule  was 3e, but 3b and 3d were found to be the most potent compounds with a similar activity for all strains. Candida albicans was the most sensitive one. In contrast, Aspergillus niger was resistant. Ecotoxicity of gemini 3e was assessed: the commercial formulation (TCMTB) was between three and four orders of magnitude more toxic than the gemini one for the biological species tested.","palabras_clave":"GEMINI SURFACTANTS|SURFACE-ACTIVE PROPERTIES|ANTIFUNGAL ACTIVITY|ECOTOXICITY BIOASSAYS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19115,"idioma_id":4,"titulo":"Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats.","resumen":"The aim of this experimental work was to evaluate deposition of titanium dioxide (TiO2 ) microparticles and nanoparticles, which could originate from titanium bioimplants, in the gingiva. Wistar rats were injected intraperitoneally (i.p.) with a suspension of TiO2 particles of different sizes (150, 10, or 5 nm). The rats were killed 12 months post-injection, and the buccal and lingual gingivae were resected and evaluated using light and scanning electron microscopy. Energy-dispersive X-ray spectroscopy (EDS) was used to confirm the presence of titanium in deposits of microparticles and nanoparticles, and the concentration of titanium in tissues was measured using inductively coupled plasma-mass spectrometry (ICP-MS). Histological examination showed that all experimental groups exhibited agglomerates, in the gingiva, of titanium particles of micrometer size range, with no associated inflammatory response. Higher concentrations of titanium traces were shown, by ICP-MS, in both buccal and lingual tissues of all experimental groups compared with their matched controls. Titanium concentrations were significantly higher in the buccal gingiva than in the lingual gingiva, and after injection with 5-nm particles than with 10-nm particles in both localizations. Titanium microparticles and nanoparticles deposit in the gingiva, and mostly on the buccal side. Gingival deposition of titanium could be considered a tissue indicator of tribocorrosion processes of titanium bioimplants.","palabras_clave":"CORROSION|GINGIVA|MICROPARTICLES|NANOPARTICLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19116,"idioma_id":4,"titulo":"The single-item lot-sizing polytope with continuous start-up costs and uniform production capacity","resumen":"In this work we consider the uniform capacitated single-item singlemachinelot-sizing problem with continuous start-up costs. A continuous startupcost is generated in a period whenever there is a nonzero production in theperiod and the production capacity in the previous period is not saturated.This concept of start-up does not correspond to the standard (discrete) startupconsidered in previous models, thus motivating a polyhedral study of thisproblem. In this work we explore a natural integer programming formulationfor this problem. We state some general properties, study the facetness propertiesof the model constraints, and present an exponentially-sized family ofvalid inequalities. We analyze the structure of the extreme points of the convexhull of its feasible region, their adjacency and bounds for the polytopediameter. Finally, we study the particular case when the demands are highenough in order to require production in all the periods. We provide a completedescription of the convex hull of feasible solutions in this case and showthat all the inequalities in this description are separable in polynomial time,thus proving its polynomial time solvability.","palabras_clave":"LOT-SIZING |CONTINUOUS START-UP|POLYHEDRAL COMBINATORICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19117,"idioma_id":4,"titulo":"Sex in the cold: taxonomic reorganization of psychrotolerant yeasts in the order Leucosporidiales","resumen":"Species of Leucosporidiales are a group of psychrotolerant yeasts with biotechnological potential. In the present work,we studied the phenotypic, genetic and sexual characteristics of three species of this genus (Leucosporidium scottii,Leucosporidiella creatinivora and Le. yakutica) to clarify the evolutionary relationship among these closely related taxa. Fromthe results obtained, it becomes clear that these yeasts can interbreed. Although genetic delimitation is possible for thethree species, the extent of nucleotide substitutions and phenotypic differences observed between them are lower thanthat expected for species that have ended the speciation process. Our taxonomic conclusion is to maintain the three taxauntil further genomic data are gathered. However, the concept of L. scottii species complex is proposed for this group ofspecies. Finally, we transfer all Leucosporidiella and Mastigobasidium species to Leucosporidium (Leucosporidiales), and, inorder to end the polyphyly condition of these taxa, we propose the new genus Pseudoleucosporidium gen. nov. and the newcombination Peudoleucosporidium fasciculatum comb. nov.","palabras_clave":"SEXUAL REPRODUCTION|YEAST|BASIDIOMYCETES|SYSTEMATICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19118,"idioma_id":4,"titulo":"Study of the influence of genes related to muscle oxidative processes on beef color","resumen":"The biochemical bases of meat color are determined by the concentration and redox state of  myoglobin, haemoglobin, cytochromes, and other pigments. Post mortem depletion of cellular   oxygen results in oxidative stresses that consume NADH and affects reducing activity, while   enzymatic detoxification influences the cellular oxidative processes, both affecting meat color. The   aim of this work was to study the influence of several genes related to cellular oxidative processes  that could affect CIELAB meat color parameters. The study was performed in steers that received a   grass-based diet combined with different supplements (grains, hays and silages). A possible   association of SNP with colorimetric parameters (a*, b* and chroma) in GSTP1 and LDHA genes   was detected (P < 0.05). Although the influence of these enzymes on meat color has been suggested   in previous studies performed at biochemical and protein expression level, further association   studies in different populations and functional studies of proteins are needed to confirm these   results.","palabras_clave":"OXIDATIVE PROCESSES|GSTP1|LDH|MEAT COLOR|SNP|GENETICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19119,"idioma_id":4,"titulo":"Nutrients in fruits as determinants of resource tracking by birds","resumen":"ruit pulp is an important source of nutrients for many bird species. Fruit-eating birds use a variety of strategies to cope with changes in the availability of fruits, exhibiting a remarkable ability to track resources. We assessed the role of nutrient availability in the fruiting environment as a factor driving resource tracking by fruit-eating birds. Fruit con- sumption by the four most common frugivorous species in a 6-ha plot in the Southern Yungas montane forest of Argentina was assessed. We determined the content of selected nutrients (soluble carbohydrates, proteins, phenols, ascorbic acid and essential minerals) in 22 fruiting plant species eaten by birds, and measured fruit?frugivore inter- actions and the availability of nutrients and dry fruit pulp mass over 2 years. There was strong temporal covariation in the availability of the selected nutrients in fruits across the study period. Similarly, the availability of nutrients in the fruiting environment co- varied with pulp mass. Fruit consumption by the four commonest bird species and the abundance of most species were positively associated with nutrient availability and dry pulp mass. Nutrient availability was a good predictor of temporal fruit tracking by three of the four commonest frugivores. Despite large differences in particular nutrient con- centrations in fruits, overall nutrient (and pulp) quantity in the fruiting environment played a greater role in fruit tracking than did the nutritional quality of individual fruits. While overall nutrient availability (i.e. across fruit) and total pulp mass were important determinants of fruit tracking, we suggest that plant species-specific differences in fruit nutrient concentration may be important in short-term foraging decisions involved in fruit choice and nutritional balance of birds.","palabras_clave":"ANDEAN MONTANE FOREST|FOOD AVAILABILITY|FORAGING STRATEGIES|FRUGIVORES|FRUIT NUTRIENT AVAILABILITY|FRUIT TRACKING|NEOTROPICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19120,"idioma_id":4,"titulo":"Expression of the tetrahydrofolate-dependent nitric oxide synthase from the green alga Ostreococcus tauri increases tolerance to abiotic stresses and influences stomatal development in Arabidopsis","resumen":"Nitric oxide (NO) is a signaling molecule with diverse biological functions in plants. NO plays a crucial role in growth and development, from germination to senescence, and is also involved in plant responses to biotic and abiotic stresses. In animals, NO is synthesized by well-described nitric oxide synthase (NOS) enzymes. NOS activity has also been detected in higher plants, but no gene encoding an NOS protein, or the enzymes required for synthesis of tetrahydrobiopterin, an essential cofactor of mammalian NOS activity, have been identified so far. Recently, an NOS gene from the unicellular marine alga Ostreococcus tauri (OtNOS) has been discovered and characterized. Arabidopsis thaliana plants were transformed with OtNOS under the control of the inducible short promoter fragment (SPF) of the sunflower (Helianthus annuus) Hahb-4 gene, which responds to abiotic stresses and abscisic acid. Transgenic plants expressing OtNOS accumulated higher NO concentrations compared with siblings transformed with the empty vector, and displayed enhanced salt, drought and oxidative stress tolerance. Moreover, transgenic OtNOS lines exhibited increased stomatal development compared with plants transformed with the empty vector. Both in vitro and in vivo experiments indicate that OtNOS, unlike mammalian NOS, efficiently uses tetrahydrofolate as a cofactor in Arabidopsis plants. The modulation of NO production to alleviate abiotic stress disturbances in higher plants highlights the potential of genetic manipulation to influence NO metabolism as a tool to improve plant fitness under adverse growth conditions.","palabras_clave":"NITRIC OXIDE|NITRIC OXIDE SYNTHASE|TETRAHYDROFOLATE|ARABIDOPSIS THALIANA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19121,"idioma_id":4,"titulo":"Nitric oxide is an ubiquitous signal for maintaining redox balance in plant cells: regulation of ascorbate peroxidase as a case study","resumen":"Oxidative and nitrosative stresses and their respective antioxidant responses are common metabolic adjustments operating in all biological systems. These stresses result from an increase in reactive oxygen species (ROS) and reactive nitrogen species (RNS) and an imbalance in the antioxidant response. Plants respond to ROS and RNS accumulation by increasing the level of the antioxidant molecules glutathione and ascorbate and by activating specific antioxidant enzymes. Nitric oxide (NO) is a free radical considered to be toxic or protective depending on its concentration, combination with ROS compounds, and subcellular localization. In this review we focus on the mechanisms of NO action in combination with ROS on the regulation of the antioxidant system in plants. In particular, we describe the redox post-translational modifications of cytosolic ascorbate peroxidase and its influence on enzyme activity. The regulation of ascorbate peroxidase activity by NO as a redox sensor of acute oxidative stress or as part of a hormoneinduced signalling pathway leading to lateral root development is presented and discussed.","palabras_clave":"ASCORBATE PEROXIDASE|REACTIVE OXYGEN SPECIES|REACTIVE NITROGEN SPECIES|NITRIC OXIDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19123,"idioma_id":4,"titulo":"Whole genome sequencing reveals a de novo SHANK3 mutation in familial autism spectrum disorder","resumen":"Introduction  Clinical genomics promise to be especially suitable for the study of etiologically heterogeneous conditions such as Autism Spectrum Disorder (ASD). Here we present three siblings with ASD where we evaluated the usefulness of Whole Genome Sequencing (WGS) for the diagnostic approach to ASD.    Methods  We identified a family segregating ASD in three siblings with an unidentified cause. We performed WGS in the three probands and used a state-of-the-art comprehensive bioinformatic analysis pipeline and prioritized the identified variants located in genes likely to be related to ASD. We validated the finding by Sanger sequencing in the probands and their parents.    Results  Three male siblings presented a syndrome characterized by severe intellectual disability, absence of language, autism spectrum symptoms and epilepsy with negative family history for mental retardation, language disorders, ASD or other psychiatric disorders. We found germline mosaicism for a heterozygous deletion of a cytosine in the exon 21 of the SHANK3 gene, resulting in a missense sequence of 5 codons followed by a premature stop codon    Conclusions  We reported an infrequent form of familial ASD where WGS proved useful in the clinic. We identified a mutation in SHANK3 that underscores its relevance in Autism Spectrum Disorder.","palabras_clave":"SHANK3|autism"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19124,"idioma_id":4,"titulo":"Early-type galaxies in the Antlia Cluster: A deep look into scaling relations","resumen":"We present the first large-scale study of the photometric and structural relations followed by early-type galaxies (ETGs) in the Antlia cluster. Antlia is the third nearest populous galaxy cluster after Fornax and Virgo (d ? 35 Mpc). A photographic catalogue of its galaxy content was built by Ferguson &amp; Sandage in 1990 (FS90). Afterwards, we performed further analysis of the ETG population located at the cluster centre. Now, we extend our study covering an area four times larger, calculating new total magnitudes and colours, instead of isophotal photometry, as well as structural parameters obtained through Sérsic model fits extrapolated to infinity. This work involves a total of 177 ETGs, out of them 56 per cent have been catalogued by FS90 while the rest (77 galaxies) are newly discovered ones. Medium-resolution GEMINI and Very Large Telescope (VLT) spectra are used to confirm membership when available. Including radial velocities from the literature, 59 ETGs are confirmed as Antlia members. Antlia scaling relations mainly support the existence of unique functions (linear and curved) that join bright and dwarf ETGs, excluding compact ellipticals (cEs). Lenticular galaxies are outliers only with respect to the curved relation derived for effective surface brightness versus absolute magnitude. The small number of bright ellipticals and cEs present in Antlia, prevents us from testing if the same data can be fitted with two different linear sequences, for bright and dwarf ETGs. However, adding data from other clusters and groups, the existence of such sequences is also noticeable in the same scaling relations.","palabras_clave":"GALAXY CLUSTERS|DWARF GALAXIES|ELLIPTICALS AND LENTICULARS|FUNDAMENTAL PARAMETERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19125,"idioma_id":4,"titulo":"Pterional transsylvian-transinsular approach in three cavernomas of the left anterior mesiotemporal region","resumen":"tObjective: To describe the pterional transsylvian?transinsular approach for cavernomas of the left anteriormesiotemporal region in three patients.Methods: A retrospective analysis of patients who underwent surgery for cavernous angiomas in thetemporal lobe was performed via the left mesiotemporal lobe (MTL). The technique was as follows:using the pterional approach, the Sylvian fissure was widely opened, distally to proximally. The temporalbranch of the middle cerebral artery was displaced medially, and once the limiting sulcus of the insulawas located, an 8 mm long corticotomy was performed, just behind the limen insulae. The dissection wasextended through the white matter until the anterior portion of the temporal horn was reached. Finally,lesion resection was performed.Results: Three patients presented with cavernomas in the anterior sector of the MTL and underwentthe transsylvian?transinsular approach. There were no deaths in this series. One patient sustained apermanent postoperative deficit, a right homonymous quadrantanopia.Conclusion: The pterional transsylvian?transinsular approach allows for selective resection of lesionslocated in the anterior mesiotemporal region (MTR) of the dominant hemisphere, while avoiding damageto the lateral or basal cortex of the temporal lobe or to structures in the dominant hemisphere.","palabras_clave":"CAVERNOMA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19126,"idioma_id":4,"titulo":"Heat treatment of calcium alginate films obtained by ultrasonic atomizing: physicochemical characterization","resumen":"Planar films of calcium alginate were obtained using an ultrasonic atomizing device. Sodium alginate solutions of 0.6% and 0.9% (w\/v) were nebulized with calcium gluconolactate solutions (gelling agent) of 0, 1, 2 and 3% (w\/v) at a flow rate of 0.3 mL min-1 for 20 min. After drying, thickness and mechanical  properties were determined. In view of the results of mechanical properties, manageability and flexibility, calcium alginate films obtained using 0.9% sodium alginate and 2% calcium gluconolactate wereselected as ?optimum dry film? samples. These samples were cut into rectangular pieces and heated at 180 C for 0, 4, 8, 12, 20 and 24 min. Thickness, mechanical and optical properties, differential scanning calorimetry (DSC) thermograms, Fourier transform infrared spectroscopy (FTIR) spectra, and scanning electron microscopy (SEM) micrographs were analyzed in order to characterize the physicochemical properties of heat-treated samples. The heat treatment produced thickness reduction, a yellow ochre  color development and an increase in the brittleness of the films. DSC, FTIR and SEM studies suggested that heat treatment produced further dehydration of dry films and thermal dehydrationedegradation ofalginate macromolecules.","palabras_clave":"CALCIUM ALGINATE FILMS|ULTRASONIC ATOMIZING|HEAT TREATMENT|PHYSICOCHEMICAL CHARACTERIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19127,"idioma_id":5,"titulo":"Implicaciones de la urbanización en la presencia, distribución y ecología reproductiva de la fauna de anuros de una ciudad del área central de Argentina","resumen":"La urbanización perturba el ecosistema natural y es causa del declinamiento de las 14 poblaciones de anfibios. En este trabajo se realizó un inventario de especies de anuros 15 presentes en una ciudad del área central de Argentina y se analizó sus aspectos reproductivos, 16 asociados a ambientes urbanos y periurbanos. Se seleccionaron 18 sitios de muestreo, que por 17 la estabilidad del cuerpo de agua, fueron clasificados en ambientes permanente, 18 semipermanente, semitemporal y temporal. Para determinar la actividad reproductiva se 19 registraron las emisiones acústicas y la presencia de estadios larvales. Se registraron 8 20 especies de anuros pertenecientes a 5 familias, que presentaron 3 modos reproductivos. La 21 mayor actividad reproductiva fue entre noviembre y febrero, meses donde las precipitaciones 22 fueron más frecuentes. Las especies L. gracilis, L. latinasus y R. arenarum ocuparon la mayor 23 cantidad de sitios, a diferencia de H. pulchellus que se encontró en un único sitio. Los 24 ambientes utilizados en mayor proporción fueron los temporales y semitemporales. En los 25 ambientes permanentes se encontraron larvas solo de R. arenarum. Debido a las exigencias 26 particulares de las especies, la diversidad de ambientes con hidroperiodos distintos, es un 27 factor clave para la conservación de una comunidad de anuros urbanos.","palabras_clave":"Urbanización |Comunidad de anuros |Ecología reproductiva |Argentina."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19128,"idioma_id":5,"titulo":"An approach for side scan sonar acoustic images segmentation using programmable logic","resumen":"In applications related to maintenance of underwater infrastructure in harbour installations, cables and pipelines, it is necessary to separate the relevant objects of study from the rest of the acoustic image obtained by sonar. Current acoustic image processing techniques require a high computational effort and time consumption due to the manipulation of large volumes of data generated by these devices. Motivated by this problem, in this paper we present an alternative for segmenting acoustic images, proposing a framework for use with programmable logic technology. We propose to perform data segmentation into three types of regions, acoustic highlight, seafloor reverberation and acoustic shadow areas, by using programmable logic and VHDL hardware description language. Finally, results obtained over seafloor images with pipeline presence and acquired with a side scan sonar from a vessel in Salvador de Bahía, Brazil are presented.","palabras_clave":"SIDE SCAN SONAR|ACOUSTIC IMAGE|PROGRAMMABLE LOGIC|HARDWARE DESCRIPTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19129,"idioma_id":5,"titulo":"Redes de energía en la Argentina del siglo XXI. Proyectos locales innovadores","resumen":"En Argentina se construyeron de forma pionera, extensas redes de electricidad, gas y combustibles. El 98% de los hogares están conectados a la red eléctrica y el 51% de la población tiene acceso al gas natural por red (INDEC 2012). A pesar de la cobertura energética amplia, aún persisten en el país algunas regiones -como el Noroeste de la Provincia de Buenos Aires NOBAdonde las redes no llegan o tienen menor densidad. La región NOBA, situada entre las ciudades de Rosario y Buenos Aires, que cuentan con infraestructura considerable para su aprovisionamiento, presenta redes eléctricas y gasíferas poco densas -especialmente hacia el interior- y escaso desarrollo de fuentes de energías alternativas. En materia de gas, faltan gasoductos troncales o regionales. En el sistema eléctrico, hay poca capacidad de generación y se necesita mayor interconexión. Desde distintos niveles se han promovido alternativas en materia de producción, transporte y distribución de energía, pero los avances aún no alcanzan para asegurar la resiliencia energética en la región NOBA. En un contexto de esta índole, actores locales se han organizado para satisfacer sus necesidades energéticas con proyectos nuevos de transporte de gas y de aprovechamiento de recursos locales renovables, con un potencial que aún no ha sido puesto en valor. Abordando proyectos energéticos locales y regionales, este trabajo propone reflexionar acerca de la nueva geografía que podría delinearse en la producción y circulación de la energía, más flexible, fiable y sustentable, fomentando la innovación y la productividad, así como la equidad regional.","palabras_clave":"ENERGIA|TERRITORIO|REDES|PROYECTO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19130,"idioma_id":4,"titulo":"Using the Web as part of the classroom in Numerical Analysis Courses","resumen":"Virtual environments are highlighted as a good option to be used as part of the classes and to extend classes outside the classroom. The research group GIE at Facultad Regional San Nicolás from the Universidad Tecnológica Nacional of Argentina, has designed and published several websites of issues of different subjects. The use of these tools in the learning process allows students to become more active, autonomous and reflective. This fact generates adequate conditions for students to understand the basic ideas presented.The aim of this paper is to present the different sites designed for Numerical Analysis Courses and the impact they had on the subject during 2014.","palabras_clave":"WEBSITES|NUMERICAL ANALYSIS|LEARNING PROCESS|EVALUATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19131,"idioma_id":4,"titulo":"Glutamate neurotransmission is affected in prenatally stressed offspring","resumen":"Previous studies from our laboratory have shown that male adult offspring of stressed mothersexhibited higher levels of ionotropic and metabotropic glutamate receptors than control rats. Theseoffspring also showed long-lasting astroglial hypertrophy and a reduced dendritic arborisation withsynaptic loss. Since metabolism of glutamate is dependent on interactions between neurons andsurrounding astroglia, our results suggest that glutamate neurotransmitter pathways might be impaired in the brain of prenatally stressed rats. To study the effect of prenatal stress on the metabolism and neurotransmitter function of glutamate, pregnant rats were subjected to restrain stress during the last week of gestation. Brains of the adult offspring were used to assess glutamate metabolism, uptake and release as well as expression of glutamate receptors and transporters. While glutamate metabolism was not affected it was found that prenatal stress (PS) changed the expression of the transporters, thus, producing a higher level of vesicular vGluT-1 in the frontal cortex (FCx) and elevated levels of GLT1 protein and messenger RNA in the hippocampus (HPC) of adult male PS offspring. We also observed increased uptake capacity for glutamate in the FCx of PS male offspring while no such changes were observed in the HPC. The results show that changes mediated by PS on the adult glutamatergic system are brain region specific. Overall, PS produces long-term changes in the glutamatergic system modulating the expression of glutamate transporters and altering synaptic transmission of the adult brain.","palabras_clave":"GLUTAMATE RELEASE|GLUTAMATE TRANSPORTERS|NMDA RECEPTOR|AMPA RECEPTOR|HIPPOCAMPUS|FRONTAL CORTEX"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19132,"idioma_id":4,"titulo":"Phase transition for the dilute clock model","resumen":"We prove that phase transition occurs in the dilute ferromagnetic nearest-neighbour q-state clock model in &#8484;d, for every q &#8805; 2 and d &#8805; 2. This follows from the fact that the Edwards-Sokal random-cluster representation of the clock model stochastically dominates a supercritical Bernoulli bond percolation probability, a technique that has been applied to show phase transition for the low-temperature Potts model. The domination involves a combinatorial lemma which is one of the main points of this article.","palabras_clave":"PHASE|TRANSITION|DILUTE|CLOCK"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19133,"idioma_id":4,"titulo":"Morphological and genetic confirmation of Jassa slatteryi (Crustacea: Amphipoda) in a harbour of Argentina","resumen":"Jassa slatteryi is reported for the first time in Mar del Plata harbour, Argentina. A morphological comparison with the originaldescription and a genetic analysis are made to corroborate the identification of specimens. The report of range expansionalong the South-western Atlantic coast is discussed.","palabras_clave":"anfipodos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19134,"idioma_id":4,"titulo":"Comparison of TCATA and TDS for dynamic sensory characterization of food products","resumen":"Temporal Check-All-That-Apply (TCATA) has recently been introduced as a method for temporal sensory product characterization. Building on the standard CATA question format, assessors select all the terms they consider applicable for describing the sensations they perceive ? and they do so at each moment of the evaluation process. Hereby, a detailed description of how the sensory characteristics of products change during consumption is obtained. This research further investigates the TCATA method, through application to products of varying complexity (yogurt, salami, cheese, orange juice, French bread, and marinated mussels) using consumers and trained panelists as assessors. More importantly, to deliver new methodological insights we compare TCATA to TDS (Temporal Dominance of Sensations). This will aid researchers to select the temporal method best suited to their needs. Across three countries, six studies were conducted. Within-subjects experimental designs were used in Studies 1-3 and involved trained panelists using both TCATA and TDS on the same set of products. In Studies 4-6, between-subjects experimental designs were used, and the assessors, who were consumers, evaluated samples using either TCATA or TDS. The results confirmed that TCATA is suitable for measuring the temporal sensory characteristics of products. By enabling identification of several sensory characteristics that are concurrently perceived in products, the results from this research also suggests that TCATA may provide a more information-rich dynamic description of the sensory characteristics of products. The TDS concept of dominance appears to hinder simultaneous multi-attribute product characterization. In terms of ability to discriminate between samples, evidence of superiority by TCATA relative to TDS was established.","palabras_clave":"temporal methods;  |sensory characterization;|check-all-that-apply questions|trained and consumers assessors"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19135,"idioma_id":4,"titulo":"Host response to respiratory syncytial virus infection","resumen":"Purpose of review. Respiratory syncytial virus (RSV) infection is the leading cause of bronchiolitis and hospitalization in young infants and causes 100,000-200,000 deaths annually. There is still no licensed vaccine against RSV infection and the therapeutic options are mainly supportive. Despite almost six decades of research, important knowledge gaps remain with respect to the characterization of immune mechanisms responsible for protection and pathogenesis, as well as to the identification of risk factors that predict the severity of infection. Recent findings  observations made in mouse models and young children suggest that the early innate immune response play a major role in the pathogenesis of bronchiolitis due to RSV infection. Recent studies have improved our understanding of the role of the adaptive immune response mediated by TH1, TH2, TH17, regulatory T cells, and CD8+ T cells, in the pathogenesis and resolution of RSV infection. Moreover, investigations performed in the last years have made important contributions to our knowledge of the immune response in young children, the principal risk group for severe disease. Summary. A comprehensive understanding of how is induced the protective and deleterious immune response during the course of RSV infection is young children remain a challenge over the coming years.","palabras_clave":"Immune Response|Neonate|RSV"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19136,"idioma_id":4,"titulo":"Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate","resumen":"During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55Gag is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly. We show that Rab27a controls the trafficking of late endosomes carrying phosphatidylinositol 4-kinase type 2 &#945; (PI4KII&#945;) toward the PM of CD4+ T cells. Hence, Rab27a promotes high levels of PM phosphatidylinositol 4-phosphate and the localized production of PI(4,5)P2, therefore controlling Pr55Gag membrane association. Rab27a also controls PI(4,5)P2 levels at the virus-containing compartments of macrophages. By screening Rab27a effectors, we identified that Slp2a, Slp3, and Slac2b are required for the association of Pr55Gag with the PM and that Slp2a cooperates with Rab27a in the recruitment of PI4KII&#945; to the PM. We conclude that by directing the trafficking of PI4KII&#945;-positive endosomes toward the PM, Rab27a controls PI(4,5)P2 production and, consequently, HIV-1 replication.","palabras_clave":"RAB27A|HIV-1|CD4+ T CELLS|EXOSOMES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19137,"idioma_id":4,"titulo":"Annotation, Phylogeny and Expression Analysis of the Nuclear Factor Y Gene Families in Common Bean (Phaseolus vulgaris)","resumen":"In the past decade, plant nuclear factor Y (NF-Y) genes have gained major interest due to their roles in many biological processes in plant development or adaptation to environmental conditions, particularly in the root nodule symbiosis established between legume plants and nitrogen fixing bacteria. NF-Ys are heterotrimeric transcriptional complexes composed of three subunits, NF-YA, NF-YB, and NF-YC, which bind with high affinity and specificity to the CCAAT box, a cis element present in many eukaryotic promoters. In plants, NF-Y subunits consist of gene families with about 10 members each. In this study, we have identified and characterized the NF-Y gene families of common bean (Phaseolus vulgaris), a grain legume of worldwide economical importance and the main source of dietary protein of developing countries. Expression analysis showed that some members of each family are up-regulated at early or late stages of the nitrogen fixing symbiotic interaction with its partner Rhizobium etli. We also showed that some genes are differentially accumulated in response to inoculation with high or less efficient R. etli strains, constituting excellent candidates to participate in the strain-specific response during symbiosis. Genes of the NF-YA family exhibit a highly structured intron-exon organization. Moreover, this family is characterized by the presence of upstream ORFs when introns in the 5' UTR are retained and miRNA target sites in their 3' UTR, suggesting that these genes might be subjected to a complex post-transcriptional regulation. Multiple protein alignments indicated the presence of highly conserved domains in each of the NF-Y families, presumably involved in subunit interactions and DNA binding. The analysis presented here constitutes a starting point to understand the regulation and biological function of individual members of the NF-Y families in different developmental processes in this grain legume.","palabras_clave":"CCAATbox|gene regulation,|legumes|transcription factors|Symbiosis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19138,"idioma_id":4,"titulo":"An historical record for the distribution of Euphractus sexcinctus (Xenarthra, Cingulata, Dasypodidae) in Argentina","resumen":"The early distribution of Euphractus sexcinctus in central southwestern Argentina is here confirmed through an historical record from La Rioja Province that was found at the Buenos Aires Museo Argentino de Ciencias Naturales Bernardino Rivadavia, and neglected since 1935.  The specimen corresponds to a complete head, with skull included, preserved in alcohol, collected by Dr. Salvador Mazza.","palabras_clave":"Mamíferos|Xenarthra|Distribución|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19139,"idioma_id":4,"titulo":"Redescription of Neotyphloceras crassispina hemisus jordan (Siphonaptera: Ctenophthalmidae: Neotyphloceratini)","resumen":"Neotyphloceras crassispina hemisus Jordan is redescribed from male and female specimens collected at the type locality (Otro Cerro, Catamarca Province, Argentina) and nearby localities. New diagnostic morphological characters for both sexes are provided, which include the shape of the upper lobe of the fixed process of clasper, the crochet of the aedeagus and the shape and chaetotaxy of the distal arm of sternum IX for males, and the contour of the distal margin of sternum VII for females.","palabras_clave":"REDESCRIPTION|NEOTYPHLOCERAS|TOPOTYPE|OTRO CERRO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19140,"idioma_id":4,"titulo":"Composite films based on chitosan and nanomagnetite","resumen":"Magnetic chitosan nanocomposite films were prepared by a simple one-step method based on the  in situ co-precipitation of nanomagnetite. Both plasticized and no-plasticized films were obtained and characterized by means of X-ray diffraction (XRD), transmission electron microscopy(TEM), scanning electron microscopy (SEM), Fourier Transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA) and mechanical (tensile) and dynamic mechanical characterization. Nanomagnetite particles formed inside chitosan films were spherical with diameters ranging from 5 to 13 nm. The film surface and morphology and mechanical behavior were greatly affected by nanoparticles concentration, leading to increasing roughness, stiffness and fragility as the iron oxide content increases. The nanoparticles interact strongly with thechitosan matrix, as was corroborated by TGA, FTIR and DRX. Even though, particles retain their magnetic characteristics and thus, composites containing more than 2 % wt. NMP exhibit magnetic behavior.","palabras_clave":"CHITOSAN|MAGNETITE|FILMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19141,"idioma_id":4,"titulo":"Profiles and technological requirements of urogenital probiotics","resumen":"Probiotics, defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host, are considered a valid and novel alternative for the prevention and treatment of female urogenital tract infections. Lactobacilli, the predominant microorganisms of the healthy human vaginal microbiome, can be included as active pharmaceutical ingredients in probiotics products. Several requirements must be considered or criteria fulfilled during the development of a probiotic product or formula for the female urogenital tract. This review deals with the main selection criteria for urogenital probiotic microorganisms: host specificity, potential beneficial properties, functional specifications, technological characteristics and clinical trials used to test their effect on certain physiological and pathological conditions. Further studies are required to complement the current knowledge and support the clinical applications of probiotics in the urogenital tract. This therapy will allow the restoration of the ecological equilibrium of the urogenital tract microbioma as well as the recovery of the sexual and reproductive health of women.","palabras_clave":"PROBIOTICS|PHARMABIOTICS|FEMALE UROGENITAL TRACT|UROGENITAL TRACT INFECTIONS|POTENTIAL BENEFICIAL PROPERTIES|TECHNOLOGICAL CHARACTERISTICS|CLINICAL ASSAYS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19142,"idioma_id":4,"titulo":"Structural factors of annonaceous acetogenins and their semisynthetic analogues related with the toxicity on Spodoptera frugiperda","resumen":"Toxic and nutritional effects of annonaceous acetogenins and their semisynthetic analogues on Spodoptera frugiperda were evaluated. Structural modification of the natural ACG, blocking the OH flanking THF with MOM, allowed us to suggest the mode of action of ACG in the membrane. Our study emphasizes the role of the flanking OH and acetyl groups of THF with the membrane hydrophilic polar head groups. They are essential structural factors in the ACG that facilitate the intermolecular interaction that dehydrates the membrane and makes it potentially toxic against Spodoptera frugiperda.","palabras_clave":"Annonaceous Acetogenins|Semisynthetic Analogues|toxicity|Spodoptera frugiperda"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19143,"idioma_id":4,"titulo":"Native fish larvae take advantage of introduced mussel larvae: field evidence of feeding preferences on veligers of the introduced freshwater bivalve Limnoperna fortunei","resumen":"Previous work has shown that the invasive bivalve Limnoperna fortunei has had a measurable impact on local food webs, but knowledge of the trophic interactions involved is still very limited. On the basis of samples collected along the lower Paraguay-middle Parana´ rivers, we studied the feeding behavior and selectivity of larval fish, with emphasis on veligers of the introduced bivalve L. fortunei. Among feeding larvae (i.e., without a yolk sac), 16.5% had only Limnoperna veligers in their guts, while 15.6% had veligers and some other prey. Half of the fish taxa recorded (8 out of a total of 16) consumed Limnoperna veligers. The Paraguay and Parana´ rivers differed strongly in the proportions of fish larvae that consumed veligers: 14 and 68%, respectively. This difference paralleled the availability of veligers in the water column, which was significantly lower in the Paraguay (0.8 ± 0.5 ind. l-1) than in the Parana´ River (5.5 ± 2.3 ind. l-1). Conversely, cladocerans, originally  the staple food of fish larvae, were more abundant in the Paraguay (consumed by 48% of the individuals) than in the Parana´ River (26%). These results indicate that, when widely available, Limnoperna veligers largely replace the original prey of fish larvae, especially in their younger stages (protolarvae).","palabras_clave":"Limnoperna fortunei|Invasive species|Prey selection|Fish larvae"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19145,"idioma_id":4,"titulo":"Silica@proton-alginate microreactors: a versatile platform for cell encapsulation","resumen":"As an alternative approach to the well known Ca(II)-alginate encapsulation process within silica hydrogels, proton-driven gelation was investigated in order to establish its capacity as a culture carrier, both isolated and embedded in an inorganic matrix. Control over the velocity of the proton-gelation front allows the formation of a hydrogel shell while the core remains liquid, allowing bacteria and microalgae to survive the strongly acidic encapsulation process. Once inside the inorganic host, synthesized by a sol-gel process, the capsules spontaneously redissolve without the aid of external complexing agents. The entrapped cells survive the two-step process to a significant extent; culture´s growth restores the initial cell count in less than two weeks. Biosynthesis of Au nanoparticles mediated by the entrapped microalgae illustrates the preservation of the biosynthetic abilities supported by this platform.","palabras_clave":"encapsulation|alginate"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19146,"idioma_id":4,"titulo":"Enhanced photocatalytic properties of core@shell SiO2@TiO2 nanoparticles","resumen":"SiO2@TiO2 core@shell nanoparticles (CSNs) have recently attracted great attention due to their unique and tunable optical and photocatalytic properties and higher dispersion of the supported TiO2. Thus, development of facile, reproducible and effective methods for the synthesis of SiO2@TiO2 CSNs and a fundamental understanding of their improved properties, derived from combination of different core and shell materials, is of great importance. Here we report a very facile and reproducible method for the synthesis of CSNs with a control of particle morphology, crystallinity and phase selectivity, and provide important insight into the effect of core@shell configuration on the photocatalytic and optical properties of SiO2@TiO2 CSNs. For this purpose, synthesis of highly dispersed anatase nanocrystals (&#8764;5 nm) of high surface area was carried out by supporting these nanocrystals on silica sub-micron spheres in the form of a porous shell of controlled thickness (10&#8213;30 nm). The amorphous TiO2 shell was crystallized into anatase using a low temperature (105 °C) hydrothermal treatment. The resulting CSNs were characterized by scanning electron microscopy, transmission electron microscopy, energy dispersive spectroscopy, x-ray photoelectron spectroscopy, x-ray diffraction, vibrational spectroscopy, zeta-potential measurements, BET surface area and electron paramagnetic resonance measurements. Both experimental data and theoretical simulations showed that due to the size of the complete particle (SiO2@TiO2), the general optical response of the system is regulated by Rayleigh scattering, exhibiting a red-shift of the extinction spectra as shell-thickness increases. The SiO2@TiO2 configuration leads to efficient light harvesting by increasing the optical path inside the core@shell particles. An enhanced photoactivity and good recyclability of SiO2@TiO2 CSNs was demonstrated compared to unsupported TiO2. Together with BET surface area measurements, direct assessment of the density of photocatalytic sites probed by electron paramagnetic resonance measurements was used to provide insight into the enhanced photocatalytic activity of CSNs, which is also understood as a consequence of Rayleigh scattering, relative enhancement of the adsorption of organic molecules on the core@shell photocatalyst surface and increased optical path inside the SiO2@TiO2 particles. All these aspects are directly influenced by the core@shell configuration of SiO2@TiO2 samples.","palabras_clave":"silica-supported anatase (SiO2@TiO2)|hydrothermal synthesis|photocatalysis|light scattering"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19147,"idioma_id":4,"titulo":"Presence of antibodies against Leptospira serovars in Chaetophractus villosus (Mammalia, Dasypodidae), La Pampa province, Argentina","resumen":"ABSTRACT: Leptospirosis is a zoonosis of worldwide distribution. The aim of this study was to examine the presence of antibodies against 21 Leptospira reactive serovars in Chaetophractus villosus in La Pampa province, Argentina, using the microscopic agglutination test (MAT). Pathologic changes compatible with leptospirosis and in situ detection of the agent by immunohistochemistry were studied in 24 and 3 individuals respectively. Only 35\/150 (23.3%) serum samples had antibodies against Leptospira sp. Six percent of the samples reacted with serovar Canicola, 4.7% with serovar Castellonis, 1.3% with serovar Icterohemorrhagieae and 0.7% with serovar Hardjo. Sixteen (10.6%) serum samples agglutinated with Castellonis-Icterohemorrhagiae and Canicola-Castellonis serovars, both with 4.7%, and Canicola-Hardjo and Castellonis-Canicola-Icterohemorrhagiae both with 0.6%. Fourteen animals had variable degrees of lesions, which were more severe in animals with higher serological titers (3200), and Leptospira sp. was detected in 3 animals by immunohistochemistry. These results represent the first record of the presence of Leptospira in C. villosus in La Pampa. Copyright © 2015 Asociación Argentina de Microbiología. Publicado por Elsevier España. All rights reserved.","palabras_clave":"LEPTOSPIRA|SEROVARS|WILDLIFE|XENARTHRA|CHAETOPHRACTUS VILLOSUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19148,"idioma_id":4,"titulo":"Chemoselective hydrogenation of unsaturated nitriles to  unsaturated primary amines: Conversion of cinnamonitrile  on metal-supported catalysts","resumen":"The liquid-phase hydrogenation of cinnamonitrile to selectively obtain the unsaturated primary amine (cinnamylamine) was studied at 383 K and 13 bar on Ni, Co, Ru and Cu metals supported on a commercial silica. Ni\/SiO2 and Co\/SiO2 were the most active catalysts for cinnamonitrile conversion but formed only small amounts of cinnamylamine. In contrast, Cu\/SiO2 and Ru\/SiO2 presented low activity for cinnamonitrile hydrogenation but formed selectively cinnamylamine in the liquid phase; nevertheless, on both samples the carbon balance was only about 40%. In an attempt of promoting the rate and yield to cinnamylamine, additional catalytic runs were carried out at higher temperatures and H2 pressures on a highly dispersed Cu(11%)\/SiO2 catalyst prepared by the chemisorption-hydrolysis method. Results showed that when cinnamonitrile hydrogenation was performed at 403 K and 40 bar on Cu(11%)\/SiO2, the yield to  cinnamylamine  was 74% giving as by-product only the unsaturated secondary amine (dicinnamylamine).","palabras_clave":"cinnamonitrile|selective hydrogenation|cinnamylamine|unsaturated nitriles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19149,"idioma_id":4,"titulo":"Impact of solvent on Co\/SiO2 activity and selectivity for the synthesis of n-butylamine from butyronitrile hydrogenation","resumen":"The impact of solvent on Co(9.8%)\/SiO2 activity and selectivity for the synthesis of n-butylamine from butyronitrile hydrogenation was investigated using methanol, benzene, toluene and cyclohexane as solvents. In non-polar solvents, the yield of n-butylamine increased from 60% to 79% following the order cyclohexane < toluene < benzene.  Nevertheless, the highest n-butylamine yield (91%) was obtained in methanol, a protic solvent. The solvent effect on the catalyst performance was interpreted by considering: i) the solvent-catalyst interaction strength; ii) the solvent polarity and its ability for H-bond formation with n-butylamine","palabras_clave":"selective hydrogenation|butyronitrile|n-butylamine|solvent effect"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19150,"idioma_id":4,"titulo":"A tale of a tail: variation during the early ontogeny of Haddadus binotatus (Brachycephaloidea: Craugastoridae) as compared to other direct-developers","resumen":"The New World direct-developing frogs (Brachycephaloidea = Terrarana) comprise nearly a thousand species that share direct development among other putative synapomorphies, yet embryonic development in this group has been thoroughly described only in about 20 species. Here we describe the early ontogeny of the craugastorid Haddadus binotatus, making specialemphasis on tail structure and development, and its differences and similarities with that of other terraranans. The morphological changes during embryonic development of H. binotatus and those of other Neotropical direct-developing species are alike, with some variation including the absence of external gills, timing of limb differentiation, and tail configuration. The tail with a rotated core axis and lateral and asymmetric fins that cover the posterior half of the embryo represents an outstanding case of developmental repatterning. We present some interpretations of the evolution of the tail and its three major aspects, the rotation of the core axis, and the origin and extensions of the fins, and pinpoint that those mechanisms underlying fin development should be fairly plastic as to allow the ontogenetic and evolutionary variation within the Brachycephaloidea clade.","palabras_clave":"ANURA|EMBRYO|DEVELOPMENTAL REPATTERNING|TAIL FINS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19151,"idioma_id":4,"titulo":"Interaction of glycine, lysine, proline and histidine with dipalmitoylphosphatidylcholine lipid bilayers: a theoretical and experimental study","resumen":"The interaction of unblocked glycine, lysine, proline and histidine (in their three forms, namely two tautomers and the protonated form) with a dipalmitoylphosphatidylcholine (DPPC) bilayer was assessed using extensive atomistic molecular dynamics simulations.","palabras_clave":"Computer Simulations|Lipid Bilayers|Amino-acids"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19152,"idioma_id":4,"titulo":"Comparison of life history traits of Tanais dulongii (Tanaidacea: Tanaididae) in natural and artificial marine environments of the south-western Atlantic","resumen":"Tanaidaceans are small benthic crustaceans  with a strictly benthic life cycle and low dispersion rates,  so they are good candidates to evaluate the effects of environment  over life history strategies and reproductive biology.  In this work, we studied two populations of Tanais  dulongii (Audouin, 1826) that live in two contrasting  habitats in order to determine whether they differ in life  history traits. The animals were obtained by systematic  sampling in a rocky shore with a lower anthropic impact  (La Estafeta: LE) and a polluted area (Mar del Plata harbour:  MdP) from March 2011 to March 2012. Seawater  temperature and salinity did not differ between sites, but  MdP showed more acid and hypoxic conditions than LE.  Population density was homogeneous and lower in MdP  (ca. 20 ind\/100 gr) than that in LE where density varied  between 250 and 800 ind\/100 gr. Reproductive individuals  and juveniles were always present, and both populations  showed two main recruitment periods: the first in spring in  both populations, and the second in summer in MdP but in  autumn?winter in LE. In both populations, sex ratio was  strongly female-biased. Juveniles, females and males from  LE had larger sizes than that from MdP and reached their  sexual differentiation at larger sizes. The estimated lifespan  was about 9 and 12 months in MdP and LE, respectively.  This study suggests that the differences observed between  populations of T. dulongii in life history traits are intimately  related to environmental differences in pH and  dissolved oxygen between habitats, but should not be discarded  a synergistic effect of temperature, organic pollution,  food availability and predation pressure.","palabras_clave":"Impacted environment \u0002 |Life history|Population dynamics|Pristine environment"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19153,"idioma_id":4,"titulo":"Outbreak of a neurotoxic side-gilled sea slug (Pleurobranchaea sp.) in  Argentinian coasts","resumen":"From 2009 to date we have been registering the outbreak of an unknown side  14 gilled sea-slug of the genus Pleurobranchaea in coastal waters of Argentina,  15 southwestern Atlantic Ocean. Examination of both external macroscopic features  16 and internal structures via electron microscopy did not allow us to conclusively  17 identify the species. Nevertheless, since Argentinian specimens closely resemble  18 Pleurobranchaea maculata (a species native from Australia and New Zealand  19 known to contain a potent neurotoxin) we performed a bioassay in our specimens  20 that was positive for neurotoxins.  21 The presence of this pleurobranch in Argentinian waters is of concern beyond  22 the ecological effects of the outbreak of a marine predator and requires urgent  23 attention. This work provides a guide to distinguish between this unidentified  24 species and the sympatric cryptogenic P. inconspicua, based on features that are  25 readily observable in fresh and preserved specimens. We discuss the potential  26 effects of this outbreak on local communities.","palabras_clave":"Gastropoda|Marine neurotoxins|Population Outbreak| Southwestern Atlantic"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19154,"idioma_id":4,"titulo":"Genomic and functional characterization of a methoprene-tolerant gene in the kissing-bug Rhodnius prolixus","resumen":"Metamorphosis, which depends upon a fine balance between two groups of lipid-soluble hormones such as juvenile hormones (JHs) and ecdysteroids, is an important feature in insect evolution. While it is clear that the onset of metamorphosis depends on the decrease of JH levels, the way in which these hormones exert their activities is not fully understood in Triatominae species. The discovery of a Drosophila melanogaster mutant resistant to the treatment with the JH analog methoprene, led finally to the description of the methoprene-tolerant gene in Tribolium castaneum (TcMet) as a putative JH receptor. Here we present the genomic and functional characterization of an ortholog of the methoprene-tolerant gene in the hemimetabolous insect Rhodnius prolixus (RpMet). The analysis of the R. prolixus gene showed that the exonic structure is different from that described for holometabolous species, although all the critical protein motifs are well conserved. Expression analysis showed the presence of RpMet mRNA in all the tested tissues: ovary, testis, rectum, Malpighian tubules and salivary glands. When juvenile individuals were  treated with RpMet specific double strand RNA (dsRNA), we observed abnormal molting events that resulted in individuals with morphological alterations (adultoids). Similarly, treatment of newly emerged fed females with dsRNA resulted in an abnormal development of the ovaries, with eggs revealing anomalies in size and accumulation of yolk, as well as a decrease in the amount of heme-binding protein. Altogether, our results validate that RpMet is involved in the transduction of JH signaling, controlling metamorphosis and reproduction in R. prolixus.","palabras_clave":"METHOPRENE-TOLERANT GENE|RHODNIUS PROLIXUS|JUVENILE HORMONE|CHAGAS DISEASE|METAMORPHOSIS|REPRODUCTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19155,"idioma_id":4,"titulo":"Experimental optic neuritis induced by the microinjection of lipopolysaccharide into the optic nerve","resumen":"Optic neuritis (ON) is a condition involving primary inflammation, demyelination, and axonal injury in the optic nerve which leads to retinal ganglion cell (RGC) loss, and visual dysfunction. We investigated the ability of a single microinjection of bacterial lipopolysaccharide (LPS) directly into the optic nerve to induce functional andstructural alterations compatible with ON. For this purpose, optic nerves from male Wistar rats remained intact or were injected with vehicle or LPS. The effect of LPS was evaluated at several time points post-injection in terms of: i) visual pathway and retinal function (visual evoked potentials (VEPs) and electroretinograms,(ERGs), respectively), ii) anterograde transport from the retina to its projection areas, iii) consensual pupil light reflex (PLR), iv) optic nerve histology, v) microglia\/macrophage reactivity (by Iba-1- and ED1- immunostaining), vi) astrocyte reactivity (by glial fibrillary acid protein-immunostaining), vii) axon number(by toluidine blue staining), vii) demyelination (by myelin basic protein immunoreactivity and luxol fast blue staining), viii) optic nerve ultrastructure, and ix) RGC number (by Brn3a immunoreactivity). LPS induced a significant and persistent decrease in VEP amplitude and PLR, without changes in the ERG. In addition, LPS induced a deficit in anterograde transport, and an early inflammatory response consisting in an increased cellularity, andIba-1 and ED1-immunoreactivity in the optic nerve, which were followed by changes in axonal density, astrocytosis, demyelination, and axon and RGC loss. These results suggest that the microinjection of LPS into the optic nerve may serve as a new experimental model of primary ON","palabras_clave":"Optic nerve|Lipopolysacharide|Optic neuritis|Visual Evoked Potentials"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19156,"idioma_id":4,"titulo":"Neogene structure of the Andean Precordillera, Argentina: insights from analogue models","resumen":"ABSTRACT. Analogue models combining different sets of preexisting structural weaknesses were developed to understand their evolution during regional ~ENE shortening. Strain analysis of simulations was performed with the GEODEF 1.1 software, a tool that allows to quantify deformation in plan view on the basis of displacement fields. Results showed up that regional NNE heterogeneities are reactivated as dextral reverse-slip structures, though NNE neoformed thrusts are also present. Likewise, dominant sinistral strike-slip motions have been obtained for reactivated second-order WNW structures whereas sinistral reverse-slip has been recorded for NW ones. Comparison of these results with structural, kinematic and paleomagnetic data supports partitioned dextral transpression for the northern Andean Precordillera since the Miocene. Moreover, models not only confirm sinistral strike-slip motions for WNW structures of the Precordillera but also suggest that they would represent preexisting crustal fabrics that were reactivated during the Andean orogeny. These cross-strike structures have played a significant role in the construction and evolution of the fold and thrust belt as they segmentate the activity of orogen-parallel structures.","palabras_clave":"Transpression|Cross-strike structures|Strain partitioning|Inherited crustal fabrics|Flat-slab subduction|GEODEF software"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19157,"idioma_id":4,"titulo":"Las Cargas: Characterization of a Southern Andean Obsidian Source and Its Prehistoric Use","resumen":"The importance of obsidian from the northern Patagonian source at Las Cargas is reflected in its early use (c. 8000 BP) and extensive geographic diffusion, but is nonetheless surprising in light of the source?s location high in the Andes Cordillera, which makes it both difficult to access under ideal conditions and inaccessible for much of the year. Given that primary obsidian sources are typically localized?often in inhospitable, hard-to-reach places?and that obsidian was a preferred material for prehistoric manufacture of some tool types, understanding how such sources were used is of particular importance to archaeologists. In northern Patagonia, more specifically, understanding prehistoric use of Las Cargas obsidian can inform interpretations of relative mobility, subsistence choices, economics of stone consumption, trade relations and territoriality. Here we present the results of various lines of evidence (surface survey, geochemical and artifact morphometric analyses, obsidian hydration dating) to characterize obsidian from Las Cargas and its prehistoric use throughout the Holocene.","palabras_clave":"GEOARCHAEOLOGY|OBSIDIAN SOURCE|SOUTHERN ANDES|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19158,"idioma_id":4,"titulo":"Histological and histochemical study of the hepatopancreas of two estuarine crab species, Cyrtograpsus angulatus and Neohelice granulata (Grapsoidea, Varunidae): influence of environmental salinity","resumen":"The aim of this study was to analyze the histology and the histochemical distribution of glycoproteins (GPs) and lipids of the hepatopancreas of Cyrtograpsus angulatus and Neohelice granulata acclimated to salinities of 10 psu (hyperregulation) and 35 psu (osmoconformation). Sections of the hepatopancreas of adult male crabs were treated with hematoxylin-eosin; Masson trichrome; Alcian Blue (pHs 2.8, 1.0, 0.5); Toluidine Blue (pHs 5.6, 4.2); periodic acid Schiff; Sudan Black and Red. At salinity 35 psu, the hepatopancreas of both species exhibited typical histological features, whereas at salinity 10 psu, detachment of the basal lamina, desquamated epithelium, disrupted brush border, loss of intercellular cohesion, hypertrophied tubular lumen, hemolymph infiltration between cells were observed in some zones. Resorptive cells (R-cells) and vacuoles of blister-like cells (B-cells) of both species show a higher glycogen content at 35 psu than at 10 psu. At lower salinities, the cytoplasm of the different cell types evidence higher contents of carboxylated GPs in N. granulata and of sulfated GPs in C. angulatus. At both salinities, and at the two pHs in N. granulata and at pH 5.6 in C. angulatus, the brush border, the vacuoles of B-cells and the peritrophic membrane show metachromasia.  R-cell vacuoles and the cytoplasm of all cell types --except for the E-cells-- at all salinities in both species show abundant lipid droplets. The results of the present study contribute significant data to the histophysiology of crustacean decapods, favoring the comprehension of the complex adjustment mechanisms facing saline stress in euryhaline crabs.","palabras_clave":"HEPATOPANCREAS|HISTOLOGY|GLYCOPROTEINS|LIPIDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19159,"idioma_id":4,"titulo":"Histochemical characterization of oocytes in the pink cuskeel (Genypterus blacodes)","resumen":"In the present study we histochemically and lectinhistochemically characterized the growing oocytes of the pink cuskeel (Genypterus blacodes). We used histochemical methods for the localizationand characterization of glycoconjugates (GCs) and lectin histochemical techniques for the identification of specific sugar residues. We analyzed presence and distribution of GCs in the differentstructures of the growing follicles (cortical alveoli, globules, yolk granules and zona radiata). During the initial stage of vitellogenesis, the oocytes presented small yolk granules composed of GCs that gradually increased during exogenous vitellogenesis. These GCs contained moderate quantities of &#945;&#945;-D-mannose, D- glucose, N-acetylglucosamine and N-acetyl-neuraminic acid. The cortical alveoli contained both neutral and carboxylated GCs, and lectin techniques detected N-acetylgalactosamine, galactose and L-fucose. The zona radiata showed a strong positive reaction to PAS and it reacted weakly with more specific techniques, such as KOH\/PA*S and PA\/Bh\/KOH\/PAS. This structure showed GCs with oxidizable vicinal diols, O-acyl sugars and sialic acid residues with different substitution types and presented N-acetylgalactosamine and L-fucose specific residues. The oocytes follicular envelope evidenced neutral and acidic non-sulfated GCs and high concentrations of &#945;&#945;-D-mannose, D-glucose, galactose and N-acetylgalactosamine. The intergranularcytoplasmic GCs were mainly rich in &#945;&#945;-D-mannose, D-glucose, N-acetylgalactosamine, N-acetilglucosamine and N-acetil-neuraminic acid. These results enhance the comprehension of the structure and functionality of the pink cuskeel ovarian follicles, and provide a useful tool for the study of this tissue in other teleost species.","palabras_clave":"Genypterus blacodes|Oocytes|Histochemistry|Glycoconjugates|Lectins"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19160,"idioma_id":4,"titulo":"Effects of size and surface functionalization of zinc oxide (ZnO) particles on interactions with bovine serum albumin (BSA)","resumen":"In this work, the behavior of bovine serum albumin (BSA) interacting with zinc oxide (ZnO) particles functionalized with 3-mercaptopropionic acid (3-MPA) and without any coating has been investigated. Two kinds of ZnO particles of different size and morphology were obtained: microwires (MW) and nanoparticles (NP). The effect of surface modification on the fluorescence properties of ZnO was studied. Typical ZnO green emission due to defects was not observed in the functionalized NP spectrum. Structure alterations of the protein interacting with ZnO particles were evaluated by fluorescence spectroscopy and circular dichroism (CD). Though BSA structure was not significantly perturbed in any case, some conformational changes were observed for BSA interacting with not functionalized MW.","palabras_clave":"zinc oxide|surface curvature|3-mercaptopropionic acid|bovine serum albumin"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19161,"idioma_id":5,"titulo":"Reglas de asociación en el cómputo de utilización de libros en una biblioteca universitaria","resumen":"Este trabajo recrea una propuesta destinada a evaluar la utilización de diferentes códigos de libros en una biblioteca universitaria. A partir de los datos de circulación de materiales almacenados en el sistema de biblioteca, el modelo aplica un mecanismo de estadísticas de utilización y un mecanismo de descubrimiento de reglas de asociación. Las estadísticas de utilización son computadas en base al grado de importancia, o pertinencia, de cada código respecto a un área de conocimiento, mientras que las reglas de asociación brindan apoyo para determinar la utilización final de los diferentes códigos. En el proceso se tiene en cuenta que los datos almacenados en el sistema corresponden a ejemplares solicitados en calidad de préstamo, renovación o consulta. El estudio introduce una alternativa de descubrimiento de conocimiento en datos, tendiente a enriquecer la gestión de una biblioteca universitaria.","palabras_clave":"Minería de Datos;|Reglas de Asociación;|Estadísticas de uso;|Biblioteca Universitaria Código Dewey"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19162,"idioma_id":4,"titulo":"Short Term Stability Using Phase Plane","resumen":"One of the most important problems in the study of transient stability of power systems is the determination of perturbation?s maximum time of permanence without losing the synchronism of the generators that feed the network. The problem is generally solved by either the application of the equal-area criterion or through numerical integration methods. In the present work, the phase-plane is proposed as an alternative tool to solve the above-mentioned problem with greater efficiency.","palabras_clave":"Short Term Stability|Phase Plane|Swing Equation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19163,"idioma_id":4,"titulo":"X-ray doses to safely release the parasitoid Diachasmimorpha longicaudata (Hymenoptera: Braconidae) reared on Anastrepha fraterculus larvae (Diptera: Tephritidae)","resumen":"Diachasmimorpha longicaudata is a koinobiont larval parasitoid that is currentlyused to control fruit flies of the genera Anastrepha, Ceratitis and Bactrocera. Inthe rearing process, a fraction of the host larvae that are exposed to parasitoidsescape from parasitism and develop into viable and fertile flies. This creates theneed to eliminate emerging flies before the parasitoids are shipped for release,increasing costs due to additional handling steps. Exposure of fly eggs or larvae to gamma-irradiation before they are parasitised has been used to reproductively sterilise hosts, or even inhibit their emergence. Our aim was to determine whether X-ray radiation applied to Anastrepha fraterculus third instar larvae before they are exposed to parasitoids, inhibits fly emergence in non-parasitised larvae without affecting the performance of the parasitoids that emerge from parasitised larvae. Three X-ray doses: 6250.2 R, 8333.6 R and 10417 R (equivalent to 60, 80 and 100 Gy, respectively) and one ã -ray dose (100 Gy) were tested. Fly emergence decreased with increasing doses of radiation, showing null values for the higher X-ray dose and the dose of 100 Gy. Irradiation showed either no impact or a positive effect on parasitism rate and fecundity. Sex rate was biased towards females in almost every dose. We conclude that the two types of radiation evaluated here were equally effective in suppressing fly emergence with no detrimental effects on the biological quality of the produced parasitoids. X-rays offer an alternative method of irradiation than the conventional radiation source, i.e. ã -rays. These results represent a significant improvement in the development of a biological control programme against A. fraterculus.","palabras_clave":"ANASTREPHA FRATERCULUS|DIACHASMIMORPHA LONGICAUDATA|X-RAY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19164,"idioma_id":4,"titulo":"A molecular contribution to the controversial taxonomical status of some freshwater snails (Caenogastropoda: Rissooidea, Cochliopidae) from the Central Andes desert to Patagonia","resumen":"For over 40 years malacologists have been discussing the taxonomical status of Heleobia species, an enigmatic genus from Cochliopidae family (Caenogastropoda: Rissooidea). As with other rissooidean families, the considerable character convergence and the paucity of anatomical synapomorphies has proved to be a problem in resolving cochliopid phylogenetic relations and establishing the validity of several nominal cochliopid species. Here we present a molecular contribution to solve the taxonomical status of one of the most abundant Southern South America cochliopid genera which has many endemic species. We report molecular evidence that supports three of the four Heleobia groups described for this region, the ?australis?, ?parchappii? and ?piscium? groups. The fourth, the ?hatcheri? group, belongs not to Heleobia but to a different genus which itself should not be considered as part of the family Cochliopidae but closely related to genus Potamolithus Pilsbry & Rush, 1896.","palabras_clave":"Cochliopidae|Heleobia|Taxonomical status|South America"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19165,"idioma_id":4,"titulo":"Complete genome sequence and integrated protein localization and interaction map for alfalfa dwarf virus, which combines properties of both cytoplasmic and nuclear plant rhabdoviruses","resumen":"We have determined the full-length 14,491-nucleotide genome sequence of a new plant rhabdovirus, alfalfa dwarf virus (ADV). Seven open Reading frames (ORFs) were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, in the order 3´-N-P-P3-M-G-P6-L-5´ . The ORFs are separated by conserved intergenic regions and the genome coding región is flanked by complementary 3´ leader and 5´ trailer sequences. Phylogenetic analysis of the nucleoprotein aminoacid sequence indicated that this alfalfa-infecting rhabdovirus is related to viruses in the genus Cytorhabdovirus. When transiently expressed as GFP fusions in Nicotiana benthamiana leaves, most ADV proteins accumulated in the cell periphery, but unexpectedly P protein was localizede xclusively in the nucleus. ADV P protein was shown to have a homotypic, and heterotypic nuclear interactions with N, P3 and M proteins by bimolecular fluorescence complementation. ADV appears unique in that it combines properties of both cytoplasmic and nuclear plant rhabdoviruses.","palabras_clave":"Alfalfa|Alfalfa dwarf virus|Cytorhabdovirus|Nucleorhabdovirus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19166,"idioma_id":4,"titulo":"Morphological and histochemical characterization of the pectoral fin muscle of the stripped weakfish, Cynoscion guatucupa","resumen":"The fibers of superficial and deep abductor muscles of the  pectoral fins of Cynoscion guatucupa  have been studied using histochemical techniques: succinic dehydrogenase (SDH)  for mitochondria, periodic acid Schiff (PAS) for glycogen, Sudan Black for  lipids, myosin-adenosintriphosphatase (mATPase) to identify different fiber  types based on the contraction speed and modified ATPase to evidence capillaries. The  fiber diameters were measured and the capillaries of the main fiber types --  red, pink and white? were counted. The two muscles showed both macroscopically  and microscopically two well differentiated zones with predominant white  fibers. The area of insertion of muscles into the fin rays had red, pink and  white fibers. The origin zone of the muscle into the bone was composed by white  fibers only. Both zones of white muscle evidenced a mosaic of small, medium and  large polygonal white fibers. Red, pink and white muscles showed a wide  histochemical diversity of fiber subtypes. The area per peripheral capillary  increased from the red to the white muscles. Because of the predominance of  white fibers, the pectoral fins of the stripped weakfish could be mainly  involved in rapid movements in order to stop\/discontinue and stabilize the body  during swimming.","palabras_clave":"PECTORAL MUSCLE|MORPHOLOGY|HISTOCHEMISTRY|CYNOSCION GUATUCUPA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19167,"idioma_id":4,"titulo":"Application of peptidases from Maclura pomifera fruit for the production of active biopeptides from whey protein","resumen":"A crude extract containing serine peptidases, was prepared from latex of Maclura pomifera fruits. Peptidases were isolated by precipitation with one volume of ethanol with a yield of 5.4 ¡¾ 0.2 Ucas per milligram of protein. This extract was employed to hydrolyse bovine whey proteins at 45 ¡ÆC and pH 6.5. Proteolytic activity was 99% inactivated after 5 minutes of heat treatment (100 ¨¬C). Major whey proteins degradation profile was analyzed by tricine SDS-PAGE. After 180 min of hydrolysis ¥á-LA and ¥â-LG were almost completely degraded. Hydrolysis degree was 31.3 ¡¾ 1.7% at 180 min of reaction and produced peptides smaller than 3 kDa were analyzed by RP-HPLC. Angiotensin-converting enzyme (ACE) inhibitory activity and antioxidant capacity were detected in the hydrolysates and IC50 values for 180 min of hydrolysis were 0.53 ¡¾ 0.02 and 4.44 ¡¾ 0.44 mg\/ml, respectively. One peptide sequence deduced from peptide masses in the 180 min filtered hydrolysate, coincided with an ACE-inhibitory peptide reported by other author. The results support the conclusion that, by the presence of ACE-inhibitory and antioxidant peptides, it would be possible to use these whey protein hydrolysates to functional food manufacture.","palabras_clave":"PLANT PEPTIDASA|MACLURA POMIFERA|WHEY HYDROLYSATE|BIOACTIVE PEPTIDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19168,"idioma_id":4,"titulo":"Metabolic dependence of phytoplankton species richness","resumen":"Aim: To analyse the dependence of phytoplankton species richness on temperature within the framework of the metabolic theory of ecology (MTE) with explicit consideration of its assumptions and predictions.  Location Lakes from the Southern Hemisphere ? South America (Argentinean  Pampa to Tierra del Fuego) and Antarctica ? and Northern Hemisphere ? North America (USA) and Europe (Denmark to Spain).  Methods: The MTE proposes that natural logarithm of species richness and the inverse of temperature are linearly related, with a slope equal to the activation energy. The MTE assumes that the total community abundance, average body size and per species average community productivity are independent of the temperature.  These predictions and assumptions are here evaluated using c. 660 phytoplankton lake communities and a literature review of 281 experimental measures of growth rate. Linear, curvilinear and segmented models were contrasted with empirical trends.  Results: Temperature?richness relationships showed a three-phase segmented form in two of the three continents. Generally, at temperatures above 17 °C and below 11 °C there was a weak relationship or none. Intermediate temperatures showed the expected positive association with richness, but with steeper slopes (c. 1) than MTE expectations (c. 0.3). Statistical models including total community  abundance and average body size explained up to 64% of the variance in richness.  Main conclusions: In its original formulation the MTE is not a satisfactory model for large-scale richness patterns in phytoplankton. However, the MTE is able to better explain richness patterns when the temperature dependence of abundances and body size are explicitly accounted for in the model. These temperature dependences improve the performance of MTE predictions but question the interpretation  of the richness?temperature slope as a measure of activation energy. The  balance among activation energy, abundance and body size produced the observed segmented pattern in temperature?richness relationships for lake phytoplankton.","palabras_clave":"PHYTOPLANCTON|METABOLIC THEORY|DIVERSITY|LATITUDINAL GRADIENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19169,"idioma_id":4,"titulo":"Bacteriocins and other bioactive substances of probiotic lactobacilli as biological weapons against  Neisseria gonorrhoeae","resumen":"n the search of new antimicrobial agents against Neisseria gonorrhoeae, the bacteriocins-producing probiotic lactobacilli deserve special attention. The inhibitory effects of biosubstances such as organic acids, hydrogen peroxide and each bacteriocin-like inhibitory substance (BLIS) L23 and L60 on the growth of different gonococcal strains were investigated. Different non-treated and treated cell-free supernatants of two probiotic lactobacilli containing these metabolites were used. The aims of this work were (i) to evaluate the antimicrobial activity of the biosubstances produced by two probiotic lactobacilli, estimating the proportion in which each of them is responsible for the inhibitory effect, (ii) to define their minimum inhibitory concentrations (MICs) and, (iii) to determine the potential interactions between these biosubstances against N. gonorrhoeae. The main antimicrobial metabolites were the BLIS-es L23 and L60 in comparison with other biosubstances. Proportionally, their contributions to the inhibition on the gonococcal growth were 87.28% and 80.66%, respectively. The MIC values of bacteriocins were promising since these substances, when diluted, showed considerable inhibitory activity for all gonococci. In the interaction between bacteriocins, 100% of synergism was found on the gonococcal growth. In summary, this study indicates that both L23 and L60 could potentially serve to design new bioproducts against N. gonorrhoeae.","palabras_clave":"BACTERIOCIN|NEISSERIA GONORRHOEAE|SUBSTANCES BIOACTIVE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19171,"idioma_id":4,"titulo":"Pharmacological effect of one icv dose of allopregnanolone in the female rat: behavioral profile","resumen":"Pharmacological effect of one icv dose of allopregnanolone in the female rat: behavioral profileLaura Tatiana Pelegrina, Carla Escudero, Fernando Alfredo Giuliani, Sebastián Marcelo Manuel García, Ricardo Jorge Cabrera and Myriam Raquel Laconi*Instituto de Medicina y Biologia Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), e Instituto de Investigaciones Biomédicas (IMBIOMED), Universidad de Mendoza. Paseo Emilio Descote 720, 5500 Mendoza, Argentina. *Corresponding author: Email: mlaconi@yahoo.com.Abstract. We have previously observed that intracerebroventricular allopregnanolone (ALLO) injection produced an anxiolytic effect and inhibited sexual receptivity when the test was performed in a separate manner. Also, ALLO reverts learning deficit in female rats in the hippocampi. To study the behavioral effects of an acute treatment with ALLO in the right lateral ventricle we used two approaches: a- A battery test to analyze the anxiety and mating behavior. And b- The avoidance test and novel object recognition test to evaluate its effect on memory and learning. Ovariectomized rats were injected with estrogen and progesterone. After it ALLO or vehicle were administered into the right lateral ventricle. To reach the objective (a) rats were put in a sequential battery test in the next order: 1-Open field. 2- Plus maze task. 3- Mating behavior. For the aim (b) it was performed a Novel Object Recognition Test and Step-down Inhibitory Avoidance Task. ALLO did not affect locomotors-exploratory behavior. Animals treated with ALLO, spent more time and had more entries into the open arm in a plus maze task and lordosis quotient was lower than in the control group. ALLO increased the latency in step down test and had no effects on discrimination index test in NORT. Here we demonstrated that one pharmacological dose of ALLO in ovariectomized primed rats is enough to generate all changes observed in the battery test. Moreover, the acute treatment with ALLO in lateral ventricle enhanced the memory acquisition in an avoidance task.","palabras_clave":"ALLOPREGNANOLONE|BEHAVIORAL|NEUROSTEROIDS|MEMORY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19172,"idioma_id":4,"titulo":"Proposal to conserve the name Bartramia curvata (Philonotis curvata) against B. fontanoides (P. fontanoides) (Bryophyta)","resumen":"Philonotis curvata (Hampe) A. Jaeger is based on Bartramia curvata Hampe, described by Hampe (l.c.) in 1862 from Colombia. It is a widespread species in South America that occurs on wet soil or rocky slopes, along roadsides, usually covered with vegetation, and is frequently found bearing sporophytes. It is a small to medium size acrocarpous plant, with stems branched by numerous sub-floral innovations, leaves lanceolate to ovate-lanceolate, with acuminate apex, margin serrate, slightly recurved below, costae sub-percurrent to percurrent, upper laminal cells rectangular to sub-linear, papillae at distal angles, basal cells quadrate to rectangular, weakly prorate at proximal angles. The sexual condition varies from dioicous, synoicous or paroicous; and the sporophyte is characterized by a horizontal capsule, striate and globose to sub-globose. Propagules (microphyllous branches) are abundant in the leaf axils. The main character to recognize this taxon is the presence of papillose-prorate cells distributed differentially in the lamina from the apex to the base. The lectotype designated here is composed of well conserved and complete plants with abundant sporophytes. The epithet curvata has been consistently applied to this species since its publication in 1862, generally as Philonotis curvata, and widely used in the bryological literature since its publication in 1875, e.g. by Hermann, Sehnem (1976), Yano (1981), Delgadillo & al. (1995), Churchill & al. (2000), Matteri (2004), O?Shea & Price (2008), and Churchill & al. (2009).  During the ongoing taxonomic revision of Philonotis Brid. in southern South America, we found that Philonotis fontanoides (Gillies ex Grev.) A. Jaeger (l.c.: 88), a neglected species from Argentina, was synonymous with P. curvata, and its basionym, Bartramia fontanoides Gillies ex Grev. predates Bartramia curvata, the basionym of P. curvata. The type material of P. fontanoides, housed at E, consists of two sheets, one with three envelopes, one labelled as being from the Greville Herbarium, and the other two labelled as from ?South America?. The other sheet came from the ?Arnott Collection? (formerly GLA) and has one specimen (E00268391). The specimen selected as the lectotype of the species is the sample barcoded E00246418 from Greville?s own herbarium, which consists of complete and well-preserved plants, and is labelled with the information detailed in the original description. Until now the identity of P. fontanoides has remained unknown and the name has been listed only in a few catalogues, e.g. in He (1998), Matteri (2003) and Greene (1986), and considered as an insufficiently known species by Crosby & al. (1999).  As the name P. fontanoides has scarcely been used and insufficiently known since its description, and in order to avoid disadvantageous nomenclatural changes (Art. 14.1 of the ICN, McNeill & al. in Regnum Veg. 154. 2011) conserving the name B. curvata, the basionym of P. curvata, against B. fontanoides, the basionym of P. fontanoides, as is here proposed, seems desirable. If this proposal is declined, the name P. fontanoides would have to replace the widely used P. curvata, which would be highly undesirable.","palabras_clave":"Proposal |Philonotis |P. fontanoides|P. curvata"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19173,"idioma_id":4,"titulo":"Interplay between endometriosis and pregnancy in a mouse model","resumen":"Objectives: to evaluate the effect of endometriosis on fertility and the levels of the IL-2 and IFN-&#947; in the peritoneal fluid in a mouse model; to evaluate the effect of pregnancy on endometriotic lesion growth, apoptosis and cell  proliferation.  Study Design: Two month old C57BL\/6 female mice underwent either a surgical procedure to induce endometriosis or a sham surgery. Four weeks after surgery mice were mated and sacrificed at day 18 of pregnancy. Number of implantation sites, fetuses and fetal weight were recorded. Endometriotic lesions were counted, measured, excised and fixed. Apoptosis and cell proliferation were evaluated in lesions by TUNEL and immunohistochemistry for PCNA respectively. Levels of IL-2 and IFN-&#947; were assessed by ELISA in the peritoneal fluid.  Results: Pregnancy rate (i.e. pregnant mice\/N) decreased in mice with endometriosis. However there were no significant differences in resorption rate, litter size and pup weight between groups.  IFN-&#947; augmented in endometriosis mice independently of pregnancy outcome. Additionally IFN-&#947; increased in pregnant endometriosis mice compared to pregnant sham animals. While IFN-&#947; increased in non pregnant versus pregnant mice in the sham group, IL-2 was increased in non pregnant mice in the endometriosis group. The size of endometriotic lesions increased in pregnant mice while apoptosis increased in the stroma and cell proliferation decreased in the epithelium of these lesions. Additionally, leukocyte infiltration, necrosis and decidualization were increased in the same lesions.  Conclusions: Pregnancy rate is reduced in this mouse model of endometriosis. Levels of IL-2 are increased in the peritoneal fluid of mice with endometriosis suggesting a role of this cytokine in infertility related to this disease. The size of endometriotic lesions is increased in pregnant mice; however pregnancy has a beneficial effect on lesions by decreasing cell proliferation and by  increasing apoptosis, decidualization and necrosis.","palabras_clave":"ENDOMETRIOSIS|PREGNANCY|INFERTILITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19174,"idioma_id":4,"titulo":"A Lindenstrauss theorem for some classes of multilinear mappings","resumen":"Under some natural hypotheses, we show that if a multilinear mapping belongs to some Banach multlinear ideal, then it can be approximated by multilinear mappings emph{belonging to the same ideal} all whose Arens extensions attain their norms at the same point. We prove a similar result for the class of symmetric  multilinear mappings. We see that the quantitative (Bollob´as-type) version of these results fails in every multilinear ideal.","palabras_clave":"integral formula|norm attaining multilinear mappings and polynomials|Lindentrauss-type theorems"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19175,"idioma_id":4,"titulo":"Bounded holomorphic functions attaining their norms in the bidual","resumen":"Under certain hypotheses on the Banach space X, we prove that the  set of analytic functions in Au(X) (the algebra of all holomorphic and uniformly continuous functions in the ball of X) whose Aron-Berner extensions attain their norms, is dense in Au(X). This Lindenstrauss type result holds also for functions with values in a dual space or in a Banach space with the so-called property (eta).  We show that the Bishop-Phelps theorem does not hold for Au(c_0;Z´´) for a certain Banach space Z, while our Lindenstrauss theorem does. In order to obtain our results, we first handle their polynomial cases.","palabras_clave":"INTEGRAL FORMULA|NORM ATTAINING HOLOMORPHIC FUNCTIONS|LINDENSTRAUSS-TYPE THEOREMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19176,"idioma_id":4,"titulo":"Draft genome sequence of Lactobacillus delbrueckii subsp. bulgaricus CRL871, a folate producing strain isolated from a Northwestern Argentinean yogurt","resumen":"Lactobacillus (L.) delbrueckii subsp. bulgaricus CRL871, is the first strain of L. bulgaricus reported as a folate-producing strain. We report the draft genome sequence of L. bulgaricus CRL871 (2,063,981 bp, GC 49.1%). This strain is of great biotechnological importance in dairy industry since constitutes an alternative to folic acid fortification.","palabras_clave":"LACTOBACILLUS BULGARICUS|FOLATE SYNTHESIS|LACTIC ACID BACTERIA|GENOME SEQUENCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19177,"idioma_id":4,"titulo":"Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5&#945;-dihydroprogesterone (5&#945;P) and can be suppressed by the 5&#945;-reductase inhibitor, finasteride","resumen":"AbstractProgesterone has long been linked to breast cancer but its actual role as a cancer promoter has remained in dispute. Previous in vitro studies have shown that progesterone is converted to 5&#945;-dihydroprogesterone (5&#945;P) in breast tissue and human breast cell lines by the action of 5&#945;-reductase, and that 5&#945;P acts as a cancer-promoter hormone. Also studies with human breast cell lines in which the conversion of progesterone to 5&#945;P is blocked by a 5&#945;-reductase inhibitor, have shown that the in vitro stimulation in cell proliferation with progesterone treatments are not due to progesterone itself but to the metabolite 5&#945;P. No similar in vivo study has been previously reported. The objective of the current studies was to determine in an in vivo mouse model if the presumptive progesterone-induced mammary tumorigenesis is due to the progesterone metabolite, 5&#945;P. BALB\/c mice were challenged with C4HD murine mammary cells, which have been shown to form tumors when treated with progesterone or the progestin, medroxyprogesterone acetate. Cells and mice were treated with various doses and combinations of progesterone, 5&#945;P and\/or the 5&#945;-reductase inhibitor, finasteride, and the effects on cell proliferation and induction and growth of tumors were monitored. Hormone levels in serum and tumors were measured by specific RIA and ELISA tests. Proliferation of C4HD cells and induction and growth of tumors was stimulated by treatment with either progesterone or 5&#945;P. The progesterone-induced stimulation was blocked by finasteride and reinstated by concomitant treatment with 5&#945;P. The 5&#945;P-induced tumors expressed high levels of ER, PR and ErbB-2. Hormone measurements showed significantly higher levels of 5&#945;P in serum from mice with tumors than from mice without tumors, regardless of treatments, and 5&#945;P levels were significantly higher (about 4-fold) in tumors than in respective sera, while progesterone levels did not differ between the compartments. The results indicate that the stimulation of C4HD tumor growth in BALB\/c mice treated with progesterone is due to the progesterone metabolite 5&#945;P formed at elevated levels in mammary cells as a result of the 5&#945;-reductase action on progesterone. The results provide the first in vivo demonstration that stimulation of breast cell tumorigenesis and tumor growth accompanying progesterone treatment is due to the progesterone metabolite 5&#945;P, and that breast tumorigenesis can be blocked with the 5&#945;-reductase inhibitor, finasteride. Copyright © 2015 Elsevier Ltd. All rights reserved.KEYWORDS: 5alpha-Dihydroprogesterone; 5alpha-Reductase; Breast cancer inhibition; Finasteride; Progesterone metabolites; Tumorigenesis","palabras_clave":"Metabolites|Progesterone|Breast cancer"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19178,"idioma_id":4,"titulo":"Geographic scale and zooarchaeological analysis of Late Holocene foraging adaptations in western Argentina","resumen":"Previous research on intensification in hunter gatherer strategies from Central West Argentina ca. 2000 years BP states that human demographic packing and overhunting of guanacos (Lama guanicoe) may have caused resource depression of this large prey animal. As a result, people broadened their diet to include smaller prey animals. Evidence supporting this conclusion includes an increase in Shannon diversity Index and a decrease in the abundance of artiodactyl remains over time in southern Mendoza. However, these studies about change in diet breadth did not consider the importance of spatial scale on analysis of prey choice and diet breadth and used the entire region as a unit of analysis. This is problematic because southern Mendoza has a heterogeneous landscape. In this paper we analyze different faunal abundance indices considering different spatial scales and the representativeness of the zooarchaeological samples. The results of the analyses show distinctive patterns of resource use over time at the macro- and sub-regional scales. Some of the difference can be explained by environmental differences between subregions and others might relate to differences in sample representativeness between subregions.","palabras_clave":"Intensificación|Zooarqueología|Sur de Mendoza|Cazadores-recolectores"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19179,"idioma_id":4,"titulo":"Application of green seaweed biomass for MoVI sorption from contaminated waters. Kinetic, thermodynamic and continuous sorption studies","resumen":"Spongomorpha Pacifica biomass was evaluated as a new sorbent for the removal of Mo(VI) from aqueous solution. The maximum sorption capacity was found to be 1280 ± 10 mg\/g at pH = 2.0 and T = 20 ºC. Sorption kinetics and equilibrium studies;  followed pseudo-second order and Langmuir adsorption isotherm models. FTIR analysis revealed that carboxyl and hydroxyl groups were mainly responsible for the sorption of Mo(VI). SEM images shows that morphological changes occurs at the surface after Mo(VI) sorption. Activation parameters and mean free energies obtained with Dubinin- Radushkevich isotherm model demonstrate that the mechanism of sorption process was chemical sorption. Thermodynamic parameters demonstrate that the sorption process was spontaneous, endothermic and the driven force was entropic. The isosteric heat of sorption decreases with surface loading, indicating that Spongomorpha Pacifica has an energetically non-homogeneous surface. Experimental breakthrough curves were simulated by Thomas and Modified Dose- Response models. The bed depth service time (BDST) model was employed to scale- up the continuous sorption experiments. The critical bed depth, Z0 was determined to be 1.7 cm. Spongomorpha Pacifica biomass results a good sorbent for Mo(VI) and it can be used in continuous treatment of effluent polluted with molybdates.  Keywords: Molybdate, Adsorption, Green Alga, Contamination","palabras_clave":"MOLYBDENUM|SORPTION|SEAWEED|CONTAMINATIO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19180,"idioma_id":4,"titulo":"Revision of Campsurus violaceus species group (Ephemeroptera: Polymitarcyidae) with new synonymies and nomina dubia in Campsurus Eaton, 1868","resumen":"The violaceus species group (formerly notatus species group) of Campsurus Eaton is revised. All the species in the violaceus  group are diagnosed. A new species, C. molinai sp. nov. is described based on male imagos from Bolivia, characterized  by their large and sclerotized penes. The violaceus group is proposed to include the following species: C. assimilis  Traver, C. truncatus Ulmer (=C. mahunkai Puthz = C. melanocephalus Pereira & da Silva, new synonyms), C. violaceus  Needham & Murphy (= C. meyeri Navás = C. notatus Needham & Murphy = C. paranensis Navás, new synonyms), C.  emersoni Traver, C. decoloratus (Hagen), and C. molinai sp.nov. Additionally we consider the following species as nomina  dubia: C. longicauda Navás, C. pfeifferi Navás, C. zikani Navás, C. albicans (orig. Ephemera albicans Percheron in  Guerin & Percheron), C. burmeisteri Ulmer, C. dallasi Navás, C. quadridentatus Eaton, C. claudus Needham & Murphy,  C. corumbanus Needham & Murphy, C. dorsalis (Burmeister), C. mutilus Needham & Murphy, and C. striatus Needham  & Murphy. Given the results presented herein (five species synonymized and 12 proposed as nomina dubia), only 28 valid  species remain in the genus Campsurus. Additionally, the nymphal stages of C. violaceus and C. truncatus are described  and illustrated. Female adult genitalia (sockets) and eggs of C. decoloratus are described for the first time. Diagnoses, new  country records, and redescriptions of selected characters of the imagos for the species of the violaceus group are given.","palabras_clave":"Campsurinae|Ephemeroidea|burrowing mayfly|taxonomy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19181,"idioma_id":4,"titulo":"Phylogeny and biogeography of Asthenopodinae with a revision of Asthenopus, reinstatement of Asthenopodes, and the description of the new genera Hubbardipes and Priasthenopus (Ephemeroptera, Polymitarcyidae)","resumen":"The Neotropical species of Asthenopodinae are revised in a formal phylogenetic context. The five knownspecies of Asthenopus Eaton, 1871, together with other five new species were included in a cladistic analysisusing morphological characters (continuous and discretes). Representatives of the Afro-Oriental groupof the subfamily (Povilla Navás, 1912 and Languidipes Hubbard, 1984) were also included to test themonophyletic hypothesis traditionally accepted for the group. Additional taxa representing the othersubfamilies of Polymitarcyidae were incorparated: Ephoron Williamson, 1802 (Polymitarcyinae) andCampsurus Eaton, 1868, Tortopus Needham & Murphy, 1924 and Tortopsis Molineri, 2010 (Campsurinae).A matrix of 17 taxa and 72 characters was analyzed under parsimony resulting in a single tree supportingthe monophyly of the subfamily Asthenopodinae. Other results include the monophyly of the Afro-Oriental taxa (Povilla and Languidipes), the paraphyletic nature of Neotropical Asthenopodinae, and therecognition of four South American genera: Asthenopus (including A. curtus (Hagen), 1861, A. angelae deSouza & Molineri, 2012, A. magnus sp. n., A. hubbardi sp. n., A. guarani sp. n.), Asthenopodes Ulmer, 1924,stat. n. (including A. picteti Hubbard, 1975, stat. n., A. traverae sp. n., A. chumuco sp. n.), Priasthenopusgen. n. (including P. gilliesi (Domínguez), 1988, comb. n.), and Hubbardipes gen. n. (including H.crenulatus (Molineri et al.), 2011, comb. n.). Descriptions, diagnoses, illustrations and keys are presented for all Neotropical taxa of Asthenopodinae (adults of both sexes, eggs and nymphs). Additionally a keyto the subfamilies and genera of Polymitarcyidae is included. A quantitative biogeographic analysis ofvicariance is presented and discussed through the study of the ?taxon history? of the group.","palabras_clave":"Ephemeroptera|Ephemeroidea|Fossoriae|vicariance"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19182,"idioma_id":4,"titulo":"Dormancy in cereals (not too much, not so little): about the mechanisms behind this trait","resumen":"As in other cultivated species, dormancy can be seenas a problem in cereal production, either due to itsshort duration or to its long persistence. Indeed, cerealcrops lacking enough dormancy at harvest can beexposed to pre-harvest sprouting damage, while along-lasting dormancy can interfere with processesthat rely on rapid germination, such as malting or theemergence of a uniform crop. Because the ancestorsof cereal species evolved under very diverseenvironments worldwide, different mechanisms havearisen as a way of sensing an appropriate germinationenvironment (a crucial factor for winter or summerannuals such as cereals). In addition, different species(and even different varieties within the same species)display diverse grain morphology, allowing somestructures to impose dormancy in some cereals butnot in others. As in seeds from many other species, theantagonism between the plant hormones abscisic acidand gibberellins is instrumental in cereal grains forthe inception, expression, release and re-induction ofdormancy. However, the way in which this antagonismoperates is different for the various species andinvolves different molecular steps as regulatory sites.Environmental signals (i.e. temperature, light qualityand quantity, oxygen levels) can modulate thishormonal control of dormancy differently, dependingon the species. The practical implications of","palabras_clave":"Cereals|dormancy|pre-harvest sproutinng"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19183,"idioma_id":4,"titulo":"S-SAD phasing of monoclinic histidine kinase from Brucella abortus combining data from multiple crystals and orientations: an example of data collection strategy and a posteriori analysis of different data combinations","resumen":"The histidine kinase (HK) domain belonging to the light-oxygen-voltage histidine kinase (LOV-HK) from Brucella abortus is a member of the HWE family, for which no structural information is available and with low sequence identity (20%) to the closest HK present in the PDB. The ?off edge? S-SAD method in macromolecular X-ray crystallography was used to solve the structure of the HK domain from LOV-HK at low resolution from crystals in a low symmetry space group (P21) and with four copies in the asymmetric unit (ca. 108 kDa). Data were collected both from multiple crystals (diffraction limit varying from 2.90 to 3.25 Å) and from multiple orientations of the same crystal, using the kappa geometry goniostat on SOLEIL beamline PROXIMA 1, to obtain ?true redundancy?. Data from three different crystals were combined for structure determination. An optimized HK construct, bearing a shorter cloning artifact, yielded crystals that diffracted X-rays to 2.51 Å and that were used for the final refinement of the model. Moreover, a thorough a posteriori analysis using several different combinations of datasets allowed us to investigate the impact of the data collection strategy on the success of the structure determination.","palabras_clave":"EXPERIMENTAL PHASING|ANOMALOUS SIGNAL|TWO-COMPONENT SYSTEM|HWE FAMILY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19184,"idioma_id":4,"titulo":"LOV histidine kinase modulates the General Stress Response system and affects the virB operon expression in Brucella abortus","resumen":"Brucella is the causative agent of the zoonotic disease brucellosis, and its success as an intracellular pathogen relies on its ability to adapt to the harsh environmental conditions that it encounters inside the host. The Brucella genome encodes a sensor histidine kinase containing a LOV domain upstream from the kinase, LOVHK, which plays an important role in light-regulated Brucella virulence. In this report we study the intracellular signaling pathway initiated by the light sensor LOVHK using an integrated biochemical and genetic approach. From results of bacterial two-hybrid assays and phosphotransfer experiments we demonstrate that LOVHK functionally interacts with two response regulators: PhyR and LovR, constituting a functional two-component signal-transduction system. LOVHK contributes to the activation of the General Stress Response (GSR) system in Brucella via PhyR, while LovR is proposed to be a phosphate-sink for LOVHK, decreasing its phosphorylation state. We also show that in the absence of LOVHK the expression of the virB operon is down-regulated. In conclusion, our results suggest that LOVHK positively regulates the GSR system in vivo, and has an effect on the expression of the virB operon. The proposed regulatory network suggests a similar role for LOVHK in other microorganisms.","palabras_clave":"BRUCELLA|GENERAL STRESS RESPONSE|HISTIDINE KINASE|VIRB"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19185,"idioma_id":4,"titulo":"Reproductive biology of Sporobolus phleoides Hack. (POACEAE) an endemic halophyte grass of Argentina.","resumen":"Sporobolus phleoides is an endemic grass of Argentina considered an important genetic resource for saline environments due to its salinity tolerance. Basic information about its reproductive biology is needed to adequately preserve its genetic variability. Hence, we studied its breeding system through phenology, embryological analysis, and self-pollination versus open-pollination treatments in six populations collected from four provinces of Argentina. The results indicated that S. phleoides is mainly autogamous with a high fertility rate. Cleistogamous and chasmogamous spikelets are isomorphic and occur simultaneously on the inflorescence, with higher percentages of cleistogamy found in the basal region of the panicle. The average percentage of cleistogamy during the study period was 23 % for all populations evaluated. The development of the embryo sac follows the typical pattern of grasses and indicates normal sexual reproduction. This study provides the basis for programming genotype collections for gene banks and future plans of domestication.","palabras_clave":"AUTOGAMY|BREEDING SYSTEM|CLEISTOGAMY|SPOROBOLUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19186,"idioma_id":4,"titulo":"Magnetic, chemical and radionuclide studies of river sediments and their variation with different physiographic regions of Bharathapuzha River, southwestern India","resumen":"Bharathapuzha River is the second longest river in southwest India, where three physiographic regions show a distinctive spatial variation and Their bed sediments can be considered environmental hosts for end-products generated by human activities and natural radionuclide components. Thus, the study of this river sediments in SW India is important not only because they are recorders of adverse human impacts (e.g., intense agricultural activities and urban pollution), but also because of their potential health hazards due to their common use as construction materials. Magnetic (e.g., magnetic susceptibility, anhysteretic remanent magnetisation and isothermal remanent magnetisation), radionuclide (226Ra, 232Th and 40K) and chemical (trace and major elements) measurements were carried out in bed sediment samples along 33 sites from the uppermost catchment downstream. Magnetic measurements show the dominance of ferrimagnetic minerals; their concentration ranges widely along the river and between regions, showing up to 7-fold higher values for concentration-dependent magnetic parameters, e.g., mean values of saturation of isothermal remanent magnetisation acquisition are 67.9 and 9.4 10 (-3)Am2 kg-1 for highland and lowland regions, respectively. Multivariate statistical analyses show the existence of relationships between magnetic, radioactivity and chemical variables. In particular, magnetic concentration-dependent parameters are significantly correlated with radioactivity variables 40K and 226Ra (with concentrations about 20% higher than the worldwide mean values), as well aswith some elements: Fe, Ca and P. Such analyses also show differences betweenphysiographic regions where samples from the highland (and lowland) region are wellgrouped showing higher (lower) magnetic concentrations and lower (higher) coercivityminerals. The spatial variation of magnetic parameters along the river can be related tothe influence of both natural sources and human activities, i.e. urbanisation and intense agricultural activities. In this sense, environmental magnetism data provide very useful tools to investigate adverse human activities occurring in the riverine environment.","palabras_clave":"magnetic parameters|major and trace elements|multivariate statistical"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19187,"idioma_id":4,"titulo":"Reproductive biology of Ziziphus mistol Griseb. (Rhamnaceae), a wild fruit tree of saline environments","resumen":"Ziziphus comprises important fruit trees that inhabit arid environments of tropical and subtropical regions of the world and are able to adapt to drought and salt stress. Species of this genus are characterized by synchronous protandrous dichogamy and self-incompatibility; however, reduced seed set after hand self-pollination indicates that self-fertilization is possible and that it causes a strong inbreeding depression. We characterize the reproductive biology of Ziziphus mistol, a species typical of saline environments of Chaco American forests. For this purpose, we studied floral biology, observed foraging behavior and pollen load of captured floral visitors, and tested the breeding system through the assessment of fruit and seed set and pollen tube growth following self-, cross-, and open pollinations treatments. In addition, the dependence of a pollinator and autonomous self-pollination were evaluated by excluding floral visitors and airborne pollen. Cross-compatibility between individuals was tested through controlled hand pollinations. Results indicate that Z. mistol is predominantly outcrossing and depends on its pollinators to produce fruits and seeds. We observed high synchrony of flowering between individuals, as well as in floral anthesis between\/within inflorescences within individuals. The flowers exhibit complete intrafloral dichogamy that fully prevents autonomous self-pollination, while sexual phases overlap within inflorescence; thus geitonogamy can easily occur. Manipulative experiments show that Z. mistol can set fruits and seeds after self- as well as cross-pollinations. However, reduction in fruit set and seed set after selfing and\/or cessation of pollen tube growth in the style suggest a self-incompatible system. From reciprocal crosses tested (N=95), we have identified only 32.6% compatible crosses via fruit and seed trials. We suggest that in Z. mistol, as well as in other species of the genus, both synchrony in floral development and partial self-incompatibility would be evolved to reduce the costs of inbreeding.","palabras_clave":"DICHOGAMY|INBREEDING DEPRESSION|SELF-INCOMPATIBILITY|RHAMNACEAE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19188,"idioma_id":4,"titulo":"Acute toxicity of Arsenic and oxidative stress responses in the embryonic development of the common South American toad Rhinella arenarum","resumen":"Arsenic, a natural element of ecological relevance, is found in natural water sources throughout Argentina in concentrations between 0.01 and 15 mg\/L. The autochthonous toad Rhinella arenarum was selected to study the acute toxicity of As and the biochemical responses elicited by the exposure to As in water during its embryonic development. The LC50 value averaged 24.3 mg\/L As and remained constant along the embryonic development. However, As toxicity drastically decreased when embryos were exposed from ?heartbeat?-stage on (4 d of development), suggesting the onset of detoxification mechanisms. Given the environmental concentrations of As in Argentina, there is a probability of exceeding lethal levels at 1 percent of sites. Arsenic at sublethal concentrations caused a significant decrease in the total antioxidant potential, but generated an increase in endogenous GSH content and GST activity. This protective response might prevent a deeper decline in the antioxidant system and further oxidative damage. Alternatively, it might be linked to As conjugation with GSH for its excretion. The authors conclude that toad embryos are more sensitive to As during early developmental stages and that relatively high concentrations of this toxic element are required to elicit mortality, but oxidative stress maybe an adverse effect at sublethal concentrations.","palabras_clave":"AMPHIBIANS|AQUATIC TOXICOLOGY|BIOMARKERS|GLUTATHIONE-S-TRANSFERASE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19189,"idioma_id":4,"titulo":"NEW AND LITTLE-KNOWN BRYOZOANS FROM MONTE LEÓN FORMATION (EARLY MIOCENE, ARGENTINA) AND THEIR PALEOBIOGEOGRAPHIC RELATIONSHIPS","resumen":"The bryozoan fauna from the South American Cenozoic is poorly known. The study of new material collected in the Monte León Formation (early Miocene), gave us the opportunity to describe four new species: Valdemunitella canui n. sp., Foveolaria praecursor n. sp., Neothoa reptans n. sp., and Calyptotheca santacruzana n. sp.Two of them (V. canui and C. santacruzana) were first recorded by F. Canu and interpreted as recent species from the Australian bryozoan fauna, but are herein described as new species. The stratigraphic range of Otionella parvula (Canu,1904) is extended to the early Miocene. The present study emphasizes the close relationships between the South American neogene bryozoan faunas and those of other Gondwanan sub-continents such as New Zealand and Australia.","palabras_clave":"BRYOZOA|EARLY MIOCENE|MONTE LEÓN FORMATION|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19190,"idioma_id":4,"titulo":"The fusion of Toxoplasma gondii SAG1 vaccine candidate to Leishmania infantum heat shock protein 83-kDa improves expression levels in tobacco chloroplasts","resumen":"  Chloroplast transformation technology has emerged as an alternative platform offering many  advantages over nuclear transformation. SAG1 is the main surface antigen of the intracellular parasite  Toxoplasma gondii and a promising candidate to produce an anti-T. gondii vaccine. The aim  of this study was to investigate the expression of SAG1 using chloroplast transformation technology  in tobacco plants. In order to improve expression in transplastomic plants, we also expressed  the 90-kDa heat shock protein of Leishmania infantum (LiHsp83) as a carrier for the SAG1 antigen.  SAG1 protein accumulation in transplastomic plants was approximately 0.1?0.2 ìg per gram of  fresh weight (FW). Fusion of SAG1 to LiHsp83 significantly increased the level of SAG1 accumulation  in tobacco chloroplasts (by up to 500-fold). We also evaluated the functionality of the  chLiHsp83-SAG1. Three human seropositive samples reacted with SAG1 expressed in transplastomic  chLiHsp83-SAG1 plants. Oral immunization with chLiHsp83-SAG1 elicited a significant  reduction of the cyst burden that correlated with an increase of SAG1-specific antibodies. We propose  the fusion of foreign proteins to LiHsp83 as a novel strategy to increase the expression level  of the recombinant proteins using chloroplast transformation technology, thus addressing one of  the current challenges for this approach in antigen protein production.","palabras_clave":"Chloroplast transformation|Hsp83|Leishmania infantum|Toxoplasma gondii"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19191,"idioma_id":4,"titulo":"Revision of the fleas of the genus Plocopsylla belonging to the complex ?angusticeps-lewisi? in the Andean region in Argentina, with the description of a new species'.","resumen":"In Argentina, the Andean biogeographic region comprises the greatest  diversity of fleas of the country. Craneopsyllinae is one of the best  represented subfamilies in this region, with some endemisms and a high  diversity. Plocopsylla is the most diverse genus of Craneopsyllinae,  including ten species that are mainly distributed in the Patagonian  subregion, parasitizing sigmodontine rodents (Cricetidae). We describe and  illustrate the morphology of the aedeagus of the species of Plocopsylla that  belongs to the angusticeps-lewisi complex. This character has diagnostic  value to differentiate species. A new species of this complex, Plocopsylla  (Plocopsylla) linardii sp. n., is described and recognized by the shape and  chaetotaxy of the distal arm of sternite IX, as well as by the shape of the  median dorsal lobe of the aedeagus. We report new host associations for  this complex, and range extensions for most of its species. Plocopsylla (P.)  silewi is reported for the first time in Argentina, and P. (P.) lewisi and P.  (P.) wilesi extend the southern limit of their distribution to Santa Cruz  Province. The ?angusticeps- lewisi? complex is found for the first time in  San Juan Province. The information may be useful in epidemiological  studies of flea-borne diseases.","palabras_clave":"Plocopsylla|Siphonaptera|Andean Region|Rodents"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19192,"idioma_id":4,"titulo":"Shape and size variations of Aegla uruguayana (Anomura, Aeglidae) under laboratory conditions: A geometric morphometric approach to the growth","resumen":"Crustacean growth studies typically use modal analysis rather than focusing on the growth of individuals. In the present work, weuse geometric morphometrics to determine how organism shape and size varies during the life of the freshwater crab, Aegla uruguayana Schmitt,1942. A total of 66 individuals from diverse life cycle stages were examined daily and each exuvia was recorded. Digital images of the dorsalregion of the cephalothorax were obtained for each exuvia and were subsequently used to record landmark configurations. Moult increment andintermoult period were estimated for each crab. Differences in shape between crabs of different sizes (allometry) and sexes (sexual dimorphism;SD) were observed. Allometry was registered among specimens; however, SD was not statistically significant between crabs of a given size. Theintermoult period increased as size increased, but the moult frequency was similar between the sexes. Regarding ontogeny, juveniles had short andblunt rostrum, robust forehead region, and narrow cephalothorax. Unlike juveniles crabs, adults presented a well-defined anterior and posteriorcephalothorax region. The rostrum was long and stylised and the forehead narrow. Geometric morphometric methods were highly effective for theanalysis of aeglid-individual- growth and avoided excessive handling of individuals through exuvia analysis.","palabras_clave":"CRUSTACEA|CEPHALOTHORAX|ONTOGENY|INTERMOULT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19193,"idioma_id":4,"titulo":"Structure and density population of the invasive mollusc Limnoperna fortunei associated with Eichhornia crassipes in lakes of the Middle Paraná floodplain","resumen":"The roots of Eichhornia crassipes provide different microhabitats for invertebrates, including substrate for the Asian invasive bivalve Limnoperna fortunei. This work evaluated the density and size structure of L. fortunei on the roots of E. crassipes in lentic water bodies associated with the Middle Paraná floodplain. The field work was carried out between November 2009-2010, covering different phases of the hydrological regime. Floating meadows of E. crassipes were sampled monthly in two lakes with different degrees of connection to the main channel of the Paraná River. Bivalve densities were not associated with variations of the biomass of E. crassipes roots and the highest mussel densities were recorded during months of high temperature. The maximum size recorded in both lakes corresponded to individuals approximately 2.5 years old; however, up to 75% of the molluscs were represented by pre-reproductive individuals (up to 6 months old). In these lakes with soft bottom and limited hard substrates, E. crassipes is an important site for the mussel attachment during its early stages of development and could not be the final site of settlement during its lifecycle.","palabras_clave":"GOLDEN MUSSEL|INVASIONS|AQUATIC MACROPHYTES|SUBSTRATE|HYDROLOGICAL REGIME|POPULATION DINAMICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19194,"idioma_id":4,"titulo":"Aggregation of mummified adult crabeater seals (Pinnipedia: Phocidae) in the eastern Antarctic Peninsula: age and sex structure,  taphonomy and cause of death","resumen":"      During  austral spring of 2012 and 2013   a group of 80 mummified crabeater seals found inland  near Cabo Bodman\/Bodman Cape in Marambio\/Seymour island was examined and necropsies were performed in order to determine  the reasons of this unusual accumulation. The group can be divided into two  subgroups, one lies on the Quebrada Larga stream and the second one is composed  by mummified seals dispersed at the base of the cliff. Age, gender, signs of  trauma, stomach and intestinal contents and evidence of viral infection were  determined for 28 seals.&nbsp; Around 82% of  the seals examined were adult individuals (79% were females). Pregnant females  and also recently born pups were found; these findings differ from most of the  previous reports since mummified seals in other sites were sub adult. Given  that all individuals sampled were negative for Morbillivirus we suppose that this group of seals  was not affected by the  mass mortality reported nearby in Prince Gustav Channel during 1955. Moreover,  since most seals found  inland at Quebrada Larga present empty stomach and slim blubber we concluded  that they died by starvation; while those dispersed at the base of the cliff  present multiple bone fractures and\/or trauma as a result of falling out from  Quebrada Larga.    ","palabras_clave":"Lobodon carcinophaga,|Marine mammal stranding|seal disorientation,|Seymour Island|virology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19195,"idioma_id":4,"titulo":"A link between Notch and progesterone maintains the functionality of the rat corpus luteum","resumen":"                We  investigated the interaction between the Notch pathway and progesterone (P) to  maintain the functionality of the corpus luteum (CL). When Notch signaling is  activated, the &#947;-secretase complex releases the active intracellular domains  (NICD) of their receptors, which exert survival effects. We designed studies to analyze whether the in vitro  inhibition of Notch affects P production, steroidogenic regulators, apoptotic parameters and signaling transduction  pathways in cultures of CL isolated from pregnant and  superovulated rats. We detected a decrease in P production when corpora lutea (CL)  were incubated with DAPT, a gamma secretase inhibitor. This effect could be in  part due to the decrease detected in the CL protein levels of P450scc since  StAR and 3&#946;-HSD were not affected by Notch inhibition. Besides, the addition of  aminoglutethimide to the CL culture medium decreased NICD of NOTCH 1. We  observed an increase in the expression of active CASPASE3 (CASP3) after Notch  inhibition which was reversed by the presence of P. The BAX\/BCLXL  ratio was increased in CL treated with DAPT and the presence of P reversed this  effect. In addition, AKT phosphorylation was inhibited in CL treated with DAPT but  had no effect on ERK activation. To demonstrate that the action of DAPT is  specifically related to the inhibition of Notch, CL were incubated with DLL4  antibody and a decrease in P production was detected. These results suggest the  existence of a novel link between P and the Notch signaling pathway to maintain  the functionality of the CL.      ","palabras_clave":"CORPUS LUTEUM|NOTCH|PROGESTERONE|OVARY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19196,"idioma_id":4,"titulo":"Inhibition of platelet-derived growth factor (PDGF) receptor affects follicular development and ovarian proliferation, apoptosis and angiogenesis in prepubertal eCG-treated rats","resumen":"The platelet-derived growth factor (PDGF) system is crucial for blood vessel stability. In the present study, we evaluated whether PDGFs play a critical intraovarian survival role in gonadotropin-dependent folliculogenesis. We examined the effect of intrabursal administration of a selective platelet-derived growth factor receptor (PDGFR) inhibitor (AG1295) on follicular development, proliferation, apoptosis and blood vessel formation and stability in ovaries from rats treated with equine chorionic gonadotropin (eCG). The percentages of preantral follicles (PAFs) and early antral follicles (EAFs) were lower in AG1295-treated ovaries than in control ovaries (p&lt;0.01-0.05). The percentage of atretic follicles (AtrFs) increased in AG1295-treated ovaries compared to control (p&lt;0.05). The ovarian weight and estradiol concentrations were lower in AG1295-treated ovaries than in the control group (p&lt;0.01 and p&lt;0.05, respectively), whereas progesterone concentrations did not change. AG1295 decreased the proliferation index in EAFs (p&lt;0.05) and increased the percentage of nuclei positive for cleaved caspase-3 and apoptotic DNA fragmentation (p&lt;0.01-0.05). AG1295 increased the expression of Bax (p&lt;0.05) without changes in the expression of Bcl-2 protein. AG1295-treated ovaries increased the cleavage of caspase-8 (p&lt;0.05) and decreased AKT and BAD phosphorylation compared with control ovaries (p&lt;0.05). AG1295 caused a decrease not only in the endothelial cell area but also in the area of pericytes and vascular smooth muscle cells (VSMCs) in the ovary (p&lt;0.05). Our findings suggest that the local inhibition of PDGFs causes an increase in ovarian apoptosis through an imbalance in the ratio of antiapoptotic to proapoptotic proteins, thus leading a larger number of follicles to atresia. PDGFs could exert their mechanism of action through an autocrine\/paracrine effect on granulosa and theca cells mediated by PDGFRs. In conclusion, these data clearly indicate that the PDGF system is necessary for follicular development induced by gonadotropins.","palabras_clave":"OVARY|PLATELET-DERIVED GROWTH FACTOR|FOLLICULOGENESIS|APOPTOSIS|ANGIOGENESIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19197,"idioma_id":5,"titulo":"Disponibilidad de rocas y costos de aprovisionamiento en el extremo austral de Patagonia meridional: integración de resultados en una escala regional","resumen":"Nuestro trabajo en el sur de Patagonia meridional estuvo orientado al estudio de la disponibilidad de rocas para la manufactura de artefactos con el objetivo de evaluar las estrategias de aprovisionamiento y explotación de las materias primas líticas implementadas por los grupos humanos durante el Holoceno tardío. Nuestro foco de trabajo ha sido el campo volcánico Pali Aike (CVPA, Santa Cruz, Argentina) y áreas vecinas, sumando un total de 84 fuentes potenciales de aprovisionamiento que han sido muestreadas. El presente trabajo persigue tres objetivos: por un lado, se presenta una síntesis de los análisis petrográficos y geoquímicos realizados, y de las principales conclusiones derivadas; por otro lado, se integran los resultados sobre la abundancia, riqueza, tamaño y calidad de las rocas para la talla por fuente potencial de aprovisionamiento en una escala regional mediante un análisis de componentes principales. Finalmente, se comparan los radios de distancia implicados en la obtención de las rocas representadas en los contextos arqueológicos por sectores del espacio y se evalúa el ajuste de diferentes modelos espaciales a través de regresión múltiple. De esta forma se discuten los costos vinculados a la obtención de los recursos líticos con el fin de ofrecer una visión integrada de la movilidad y uso del espacio por parte de las poblaciones cazadoras-recolectoras que ocuparon el sur de Patagonia meridional.","palabras_clave":"MATERIAS PRIMAS LÍTICAS|DISPONIBILIDAD|COSTOS DE APROVISIONAMIENTO|SUR DE PATAGONIA MERIDIONAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19198,"idioma_id":4,"titulo":"Variation of body size and degree of melanism in the Liolaemus goetschi lizards clade: Is it driven by latitudinal and climatic gradients?","resumen":"                    Body size (BS) varies in response to  several selective pressures. In ectotherms, thermal inertia may 5 affect  thermoregulation, since larger BS increase heat conservation as Bergmann  originally stipulated for endotherms. However, Bergmann?s rule is controversial  in ectotherms. The heat balance hypothesis states that ectotherms?  thermoregulatory capability is relevant for trends in BS. In cold climates,  larger BSs would be advantageous for small thermorregulating ectotherms, by  increasing heat conservation. However, BS implies a delaying effect on heating  too, therefore ectotherms may need another trait to compensate the later effect.  Thermal melanism hypothesis posits that melanism increases heat gain, and may  be adaptive for animals inhabiting cold climates. We propose that the higher  solar radiation absorption from increased melanism may be such a compensatory  trait. We expect BS and melanism to increase with latitude in response to  seasonal temperatures and solar radiation. To test this, we studied the  monophyletic Liolaemus goetschi group of lizard species across its 2200 km  (32-48° S latitude) range. We used phylogenetically  informed analyses to study geographic variation of BS and melanism (dorsal,  ventral and total) in relation to temperatures, thermal amplitude, cloudiness,  and net solar radiation. Our results show that lizards? BS increases latitudinally  in relation to thermal amplitude and temperature. Only ventral melanism varied latitudinally,  but all melanism variables varied in response to cloudiness and net radiation.  The relationship between BS and melanism was significant and positive in all  cases. We suggest thermal inertia may be a fair candidate mechanism explaining  geographic variation in BS (heat balance hypothesis), while melanism may  influence heat gain according to the thermal melanism hypothesis. Although, it  remains unclear why latitudinal variation is related to ventral instead of  dorsal melanism, and further investigation is needed to clarify the  relationship between BS and melanism in light of cold climates.  ","palabras_clave":"THERMAL MELANISM HYPOTHESIS|HEAT BALANCE HYPOTHESIS|BODY SIZE|BERGMANN´S RULE|ECTOTHERMS|LIZARD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19199,"idioma_id":4,"titulo":"Thermal sensitivity of cold climate lizards and the importance of distributional ranges","resumen":"One of the fundamental goals in macroecology is to understand the relationship among species? geographic ranges, ecophysiology, and climate; however, the mechanisms underlying the distributional geographic patterns observed remain unknown for most organisms. In the case of ectotherms this is particularly important because the knowledge of these interactions may provide a robust framework for predicting the potential consequences of climate change in these organisms. Here we studied the relationship of thermal sensitivity and thermal tolerance in Patagonian lizards and their geographic ranges, proposing that species with wider distributions have broader plasticity and thermal tolerance. We predicted that lizard thermal physiology is related to the thermal characteristics of the environment. We also explored the presence of trade-offs of some thermal traits and evaluated the potential effects of a predicted scenario of climate change for these species. We examined sixteen species of Liolaemini lizards from Patagonia representing species with different geographic range sizes. We obtained thermal tolerance data and performance curves for each species in laboratory trials. We found evidence supporting the idea that higher physiological plasticity allows species to achieve broader distribution ranges compared to species with restricted distributions. We also found a trade-off between broad levels of plasticity and higher optimum temperatures of performance. Finally, results from contrasting performance curves against the highest environmental temperatures that lizards may face in a future scenario (year 2080) suggest that the activity of species occurring at high latitudes may be unaffected by predicted climatic changes.","palabras_clave":"ECOPHYSIOLOGY|LIOLAEMUS|PATAGONIA|PERFORMANCE|SPECIES' DISTRIBUTION RANGES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19200,"idioma_id":5,"titulo":"Propiedades antioxidantes de mezclas de extractos acuosos de especies aromáticas de zonas áridas de Jujuy","resumen":"Se utilizó un diseño Simplex Centroide para investigar el efecto de la mezcla sobre la actividad antioxidante de extractos obtenidos por decocción a partir de Aphyllocladus spartioides, Acantholippia salsoloides y Schinus areira. Las mezclas más activas resultaron cuando el extracto de hojas de S. areira está presente en mayor proporción.","palabras_clave":"Antioxidantes, medicinales, mezclas"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19201,"idioma_id":4,"titulo":"Costs of dental rehabilitation. State Policies to reduce inequalities","resumen":"In Latin American countries, oral health is often seen by health?s authorities as a luxury good since high costs for health system.  In Argentina 33 % of population had lost teeth when they reach young adults age. Our group previous demonstrated that lack of teeth marginalizes and exclude young people them from job?s opportunities.  Objective: To determinate the impact of a public health program for population with severe dental problems.   Methods: We conducted a prospective study where dental health status, type of prostheses, cost of prosthetic rehabilitation, quality of life and patient?s socio-economic conditions were considered as variables. Patient?s selection was randomized performed among volunteers with dental pieces missed. Two groups were considered: those patients in whom prostheses were provided by a public health program (group A); and another group where prostheses were accessed in the private sector. 300 patients were enrolled in the study.  A bivariate analysis was performed.  Results: the average cost to provide prostheses and oral rehabilitation per patient was ? 1785.38 in the private sector while for the state program was ? 268.51, which meant over 85% of saving. High satisfaction of users and an increased self-confidence of patients were achieved.  Conclusion: Missing teeth causes social and economic exclusion. This paper evidences a low-cost State program that reduced 85% the regular prices for dental prostheses. This experience can provide the groundwork for massively increase access to oral health care, thereby fulfilling with the State´s duty to ensure overall health for vulnerable populations.","palabras_clave":"Cost|Dental|Care"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19202,"idioma_id":5,"titulo":"'P 96 (Punta Entrada, Santa Cruz): un sitio arqueológico costero al sur del río Santa Cruz?.","resumen":"P 96 es un sitio arqueológico costero en la desembocadura del río Santa Cruz, conformado por restos de vertebrados y artefactos líticos en un sustrato arenoso, con fechados correspondientes al Holoceno tardío. Los restos de fauna muestran la explotación exhaustiva de un apostadero reproductivo de lobos marinos y el aprovechamiento ocasional de cormoranes y guanacos. La tecnología lítica, expeditiva y confeccionada en materias primas locales e inmediatamente disponibles, con gran cantidad de filos activos descartados y de piezas agotadas pero con tamaños que permitirían ser reactivados, evidencia el conocimiento previo que tenían los cazadores recolectores sobre los recursos que ofrecía este sector de la costa. Las ocupaciones humanas fueron cortas, temporalmente espaciadas entre sí y testimonian el uso recurrente de este sector a lo largo de 800 años con el propósito de explotar los apostaderos de pinnípedos.","palabras_clave":"CAZADORES RECOLECTORES|HABITATS COSTEROS|ZOOARQUEOLOGÍA|ESTRATEGIAS TECNOLOGICAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19203,"idioma_id":4,"titulo":"Human Predation and Natural History of Huemul (Cervidae; Hippocamelus bisulcus Molina) in Patagonia: a Zooarchaeological Analysis","resumen":"We use published zooarchaeological evidence to discuss the various hypotheses concerning the past distribution of huemuls in Patagonia, southern South America. We then use these data to evaluate the interactions between this cervid and hunter-gatherers during the Holocene. The zooarchaeological record showsthat huemul mainly inhabited forested and forest?steppe ecotonal environments during the Holocene. Huemul were hunted in exceptional circumstances during the early occupation of Patagonia. Its presence in the zooarchaeological record of South Patagonia increases after 9500 BP and is more frequent after 2200 BP.However, the taxonomic contribution of the species? bone remains to the archaeological record is always low. The few assemblages where there are a high number of huemul bones would have been the result of opportunistichunting episodes. This in turn suggests that hunting of huemul had little or no influence on the animal?s regional distribution over time. However, the progressively greater human presence in some forested areas towards the end of the Holocene could have affected huemul populations at the local scale. The zooarchaeological information presented in this paper illustrates interspecific and long-term relationships and, hence, could serve as essential information in future management strategies for huemul in Argentina and Chile.","palabras_clave":"zooarchaeology|Hippocamelus bisulcus|Patagonia|conservation biology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19204,"idioma_id":4,"titulo":"The Absortion Theory - The dream of eating without gaining weight","resumen":"Obesity is classically considered a worldwide epidemic disease and as one of the most important causes of morbid-mortality in many countries.Medical science explains obesity and bases its treatment in the following mathematical equation that enunciates Calories consumed from food as a consequence of calories expended and calories transformed in fat and stored.This work puts challenged this equation and proposes arguments based on the evolution of the human beings which includes the importance of the relation between hunger and satiety.Like in any other endocrine systems, it is proposed the existence of an hypothalamic hormone that regulates the volume of the adipose tissue through the leptin action.Regulation of the body weight should be based on the equilibrium of the energetic saving capacity, nutrient absorption and nutrient storage.Our proposal is that the energetic system of abundance regulates the relationship between hunger and satiety; and explains why slim people that eat large amounts of food do not gain weight, why people that have harmful eating habits gain weight and why some people maintain a stable overweight along vast periods of time.Following these precepts it is propose that treatments for obesity should be based on the physiological model that includes not only the calories ingested-expended ratio, but also aspects that regulates satiety and modulate the size of the adipose tissue as happened with our ancestors.","palabras_clave":"Nutrition|Absortion|Weight|Formula"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19205,"idioma_id":4,"titulo":"EFFECT OF DIFFERENT TYPES OF SESQUITERPENE LACTONES ON THE MATURATION OF Rhinella arenarum OOCYTES","resumen":"The sesquiterpene lactones (STLs) are a large class of plant secondary metabolites that are generally found in the Asteraceae family and that have high diversity with respect to chemical structure as well as biological activity. STLs have been classified into different groups, such as guaianolides,germacranolides, and melampolides etc., based on their carboxylic skeleton. In amphibians, fully grown ovarian oocytes are arrested at the beginning of meiosis I. Under the stimulus of progesterone, this meiotic arrest is released and meiosis progresses to metaphase II, a process known as oocyte maturation. The purpose of this work was to determine whether sesquiterpene lactones from thegermacranolide and melampolide groups act as inhibitor agents on the meiosis of amphibian oocytes in vitro. Results for germacranolides indicated that the addition of deoxyelephantopins caused a high degree of inhibition and that minimolide showed a moderate inhibitory effect, whereas glaucolide A was inactive. Furthermore, the addition of melampolides (uvedalin, enhydrin, polymatin A and polymatin B) showed inhibitory effects. For enhydrin and uvedalin, inhibitory effects were observed at the higher concentrations assayed. The results of this study suggest that the inhibitory activity of thetested sesquiterpene lactones on the meiosis of Rhinella arenarum oocytes is not dependent on the group to which they belong, i.e. not on the carboxylic skeleton, but probably due to the arrangement and type of function groups present in the molecules. All assayed lactones in the germacranolide group showed low toxicity. In contrast, important differences in toxicity were observed for lactones from the melampolide group: enhydrin and uvedalin showed low toxicity, but polymatin A and B were highly toxic.","palabras_clave":"AMPHIBIAN |MEIOSIS|OOCYTE MATURATION|SESQUITERPENE LACTONES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19206,"idioma_id":4,"titulo":"Geographic distribution of the short-tailed river stingray (Potamotrygon brachyura): assessing habitat loss and fishing as threats to the world?s largest obligate freshwater elasmobranch","resumen":"Freshwater elasmobranchs are threatened but little is known about them. Potamotrygon brachyura is theworld?s largest obligate freshwater elasmobranch. This makes it popular among fishermen and suggests a susceptibility toanthropogenic threats. We collected records of P. brachyura (n¼70) from media, fishermen and scientific sampling, toestimate its global geographic distribution (using both generalised additive and MaxLike models). Then, we estimated thespecies? exposure to habitat modification and fishing pressure, by applying multinomial ordinal models with threat levelsas response and the presence or absence of P. brachyura as an independent variable. Distance to coast, depth, watertemperature range, salinity range and mean water temperature were the main determinants of the distribution in the R&#305;´o dela Plata. This resulted in a narrow coastal distribution. In the Uruguay and Parana´ River basins, the probability ofoccurrence was positively associated with flow accumulation, percentage of open water and submerged vegetation, andlowland ecoregions, and negatively to wetness index and altitude. This limited the distribution to large lowland rivers.Approximately 41% of the range of P. brachyura in the R&#305;´o de la Plata was subject to high habitat modification. In theUruguay and Parana´ River basins, this percentage reached 7%; however, the overlap with high fishing pressure was 59%.For conservation purposes, P. brachyura may function as an umbrella species.","palabras_clave":"CHONDRICHTHYES|PANTANAL|PARANA RIVER|RIO DE LA PLATA BASIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19207,"idioma_id":4,"titulo":"Limited infant exposure to benznidazole through breast milk during maternal treatment for Chagas disease","resumen":"BACKGROUND: Benznidazole (BNZ) is safe and effective for the treatment of paediatric Chagas disease. Treatment of adults is also effective in many cases, but discouraged in breastfeeding women because no information on BNZ transfer into breast milk is available. We aimed to evaluate the degree of BNZ transfer into breast milk in lactating women with Chagas disease.PATIENTS AND METHODS: Prospective cohort study of lactating women with Chagas disease treated with BNZ administered for 30&#8197;days. Patients and their breastfed infants were evaluated at admission, the 7th and 30th day of treatment (and monthly thereafter, for 6&#8197;months). BNZ was measured in plasma and milk by high performance liquid chromatography. The protocol was registered in ClinicalTrials.gov (#NCT01547533).RESULTS: 12 lactating women with chronic Chagas disease were enrolled (median age 28.5&#8197;years, range 20-34). Median BNZ dose was 5.65&#8197;mg\/kg\/day twice daily. Five mothers had adverse drug events (45%), but no adverse drug reactions or any untoward outcomes were observed in the breastfed infants. Median milk BNZ concentration was 3.8&#8197;mg\/L (range 0.3-5.9) and 6.26&#8197;mg\/L (range 0.3-12.6) in plasma. Median BNZ milk to plasma ratio was 0.52 (range 0.3-2.79). Median relative BNZ dose received by the infant (assuming a daily breast milk intake of 150&#8197;mL\/kg\/day) was 12.3% of the maternal dose per kg (range 5.5%-17%).CONCLUSIONS: The limited transference of BNZ into breast milk and the reassuring normal clinical evaluation of the breastfed babies suggest that maternal BNZ treatment for Chagas disease during breast feeding is unlikely to present a risk for the breastfed infant.TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT01547533.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http:\/\/group.bmj.com\/group\/rights-licensing\/permissions.","palabras_clave":"CHAGAS DISEASE|BENZNIDAZOLE|BREASTFEEDING|PEDIATRIC CLINICAL PHARMACOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19208,"idioma_id":4,"titulo":"Pulmonary function of a paediatric cohort of patients with postinfectious bronchiolitis obliterans. A long term follow-up","resumen":"BACKGROUND:     Postinfectious   bronchiolitis obliterans (BO) is a chronic respiratory disease that   usually follows a severe adenovirus infection.    OBJECTIVE:     To determine the evolution of pulmonary function and clinical outcome of children with postinfectious BO during childhood.    METHODS:     The   study included patients diagnosed with postinfectious BO in whom at   least two spirometries were performed within a minimum interval of   3&#8197;months.    RESULTS:     46   met the inclusion criteria. The mean (±SD) follow-up period was 12.5   (±3.5) years. 197 spirometries and 41 plethysmographies were performed.   Initial (9±3&#8197;years old) lung function was as follows (z score, mean±SD):   forced vital capacity (FVC) -3.8±1; forced expiratory volume in 1 s   (FEV1) -4.4±1; FEV1\/FVC -2.2±1; forced expiratory flow (FEF)(25-75)   -3.7±1; total lung capacity (TLC) 120±26%; residual volume (RV)   309±108%; and RV\/TLC 55±13. During childhood, FVC and FEV1 increased by a   mean of 11%\/year (95% CI 9.3% to 12.6%; p&lt;0.0001) and 9%\/year (95%   CI 7.7% to 10.2%; p&lt;0.0001), and the FEV1\/FVC ratio decreased by   1.9%\/year (95% CI 1% to 2.8; p&lt;0.001). The z score for FVC, FEV1 and   FEV1\/FVC decreased by 0.07 z score\/year (95% CI 0.1 to 0.01; p&lt;0.05),   0.09 z score\/year (95% CI 0.1 to 0.05; p&lt;0.01) and 0.04 z score\/year   (95% CI 0.09 to 0.001; p&lt;0.02), respectively. During the follow-up   period, 69% of patients required at least one hospital readmission and   five required mechanical ventilation. Nine patients developed a thoracic   deformity, and seven whose bronchiectasis did not respond to clinical   treatment underwent a lobectomy.    CONCLUSIONS:     After   a 12 year follow-up period, pulmonary function remained severely   impaired, showing an obstructive pattern with air trapping that slowly   improved during childhood. An unequal growth of lung parenchyma over the   airways suggests dysinaptic growth. Patients required frequent   readmission due to recurrent respiratory infections, and hypoxaemia   improved slowly over time.","palabras_clave":"PEDIATRIC LUNG DISEASE|PEDIATRIC CLINICAL PHARMACOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19209,"idioma_id":4,"titulo":"Prevention of congenital Chagas through treatment of girls and women of childbearing age","resumen":"It is currently unknown whether treatment of Chagas disease decreases the risk of congenital transmission from previously treated mothers to their infants. In a cohort of women with Chagas disease previously treated with benznidazole, no congenital transmission of the disease was observed in their newborns. This finding provides support for the treatment of Chagas disease as early as possible.","palabras_clave":"Trypanosoma cruzi|Chagas disease|treatment|prevention|congenital transmission"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19210,"idioma_id":4,"titulo":"First report of Bean common mosaic virus, peanut strain, infecting peanut in Argentina","resumen":"Peanut or groundnut (Arachis hypogaea) is an important oilseed crop in Argentina, where it is used primarily for direct human consumption (confectionery peanut). In the 2009-10 and 2010-11 cropping seasons, peanut plants with virus-like symptoms were detected in the growing area of Jujuy and Salta provinces, northwestern Argentina, in fields sown with seeds from Bolivia. Leaf symptoms included systemic mild or severe mottling, blotching and stripes along the lateral veins, sometimes with the presence of chlorotic rings, suggesting the presence of Peanut mottle virus (PeMoV) or peanut strain of Bean common mosaic virus (BCMV-PST). A total of 47 symptomatic young leaf samples were collected during both cropping seasons. Serological assays revealed that 21 samples were positive for BCMV, 16 were PeMoV-positive, and 3 were coinfected with the two viruses. RT-PCR assay showed that a single band of the expected size (~234 bp) was obtained from serologically BCMV-positive samples, whereas samples infected with PeMoV yielded a ~327-bp fragment. Both fragments were amplified in mixed infections. Total nucleic acids from two samples positive for BCMV were purified using CTAB extraction method and total RNA was sequenced. High-quality sequences were de novo assembled and the identity of contigs was analysed. BLAST analyses successfully identified several contigs corresponding to BCMV-PST genome. This is thought to be the first report of BCMV-PST infecting peanut in Argentina. The virus is transmitted by aphids in a nonpersistent manner and by seeds","palabras_clave":"POTYVIRUS|MOLECULAR IDENTIFICATION|PEANUT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19211,"idioma_id":4,"titulo":"Fasting enhances pyroglutamyl peptidase II activity in tanycytes of the mediobasal hypothalamus of male adult rats","resumen":"Fasting down-regulates the hypothalamus-pituitary-thyroid (HPT) axis activity through a reductionof thyrotropin releasing hormone (TRH) synthesis in neurons of the parvocellular paraventricularnucleus of the hypothalamus (PVN). These TRH neurons project to the median eminence (ME),where TRH terminals are close to the cytoplasmic extensions of 2 tanycytes. Tanycytes expresspyroglutamyl peptidase II (PPII), the TRH-degrading ectoenzyme that controls the amount of TRHthat reaches the anterior pituitary. We tested the hypothesis that regulation of ME PPII activity isanother mechanism by which fasting affects the activity of the HPT axis. Semi-quantitative in situhybridization histochemistry data indicated that PPII and deiodinase 2 mRNA levels increased intanycytes after 48 h of fasting. This increase was transitory, followed by an increase of PPII activityin the ME, and a partial reversion of the reduction in PVN pro-TRH mRNA levels and the numberof TRH neurons detected by immunohistochemistry. In fed animals, adrenalectomy and corticosterone treatment did not change ME PPII activity 72 h hour later. Methimazole-induced hypothyroidism produced a profound drop in tanycytes PPII mRNA levels, which was reverted by 3 days of treatment with T4. The activity of thyroliberinase, the serum isoform of PPII, was increased at most fasting time points studied. We conclude that delayed increases in both the ME PPII as well as the thyroliberinase activities in fasted male rats may facilitate the maintenance of the deep down-regulation of the HPT axis function, in spite of a partial reactivation of TRH expression in the PVN.","palabras_clave":"THYROID|TRH|TSH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19212,"idioma_id":4,"titulo":"Role of the Pseudomonas quinolone signal (PQS) in sensitising Pseudomonas aeruginosa to UVA radiation","resumen":"One of  the most important stress factors that bacteria must face in the environment is  solar ultraviolet-A (UVA) radiation, leading to lethal effects through  oxidative damage. The aim of this work was to investigate the role of the  2-heptyl-3-hydroxi-4-quinolone (the Pseudomonas  quinolone signal or PQS) in the response of P.  aeruginosa to UVA radiation. PQS  is an intercellular quorum sensing signal associated to membrane vesicles that,  among other functions, regulates genes related to iron acquisition, forms  stable complexes with this metal and participates in oxidative phenomena. UVA  exposure of the wild-type PAO1 strain and a pqsA  mutant unable to produce PQS revealed a sensitizing role for this signal. The  studies aimed to investigate the mechanism involved in this phenomenon revealed  that catalase, an essential factor in the UVA defense, is not related with the  PQS-mediated UVA sensitivity. Absorption of UVA by PQS produces its own  photo-degradation, oxidation of the probe 2?,7?-dichlorofluorescein and generation  of singlet oxygen and superoxide anion, suggesting that this signal could be  acting as an endogenous photosensitizer. The results presented in this study could  explain the high sensitivity to UVA of P.  aeruginosa when compared to enteric bacteria","palabras_clave":"pseudomonas|Ultraviolet-A|UVA|PQS|2-heptyl-3-hydroxi-4-quinolone|quorum sensing"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19213,"idioma_id":4,"titulo":"Introducing Simple Detection of Bioavailable Arsenic by Using the ARSOlux Biosensor in Rafaela, Santa Fe Province in Argentina","resumen":"Numerous articles have reported the occurrence of arsenic in drinking water in Argentina, and the resulting health effects in severely affected regions of the country. Arsenic in drinking water in Argentina is largely naturally occurring due to elevated background content of the metalloid in volcanic sediments, although, in some regions, mining can contribute. While the origin of arsenic release has been discussed extensively, the problem of drinking water contamination has not yet been solved. One key step in progress towards mitigation of problems related with the consumption of As-containing water is the availability of simple detection tools. A chemical test kit and the ARSOlux biosensor were evaluated as simple analytical tools for field measurements of arsenic in the groundwater of Rafaela (Santa Fe, Argentina), and the results were compared with ICP-MS and HPLC-ICP-MS measurements. A survey of the groundwater chemistry was performed to evaluate possible interferences with the field tests. The results showed that the ARSOlux biosensor performed better than the chemical field test, that the predominant species of arsenic in the study area was arsenate and that arsenic concentration in the studied samples had a positive correlation with fluoride and vanadium, and a negative one with calcium and iron.","palabras_clave":"BIOAVAILABLE ARSENIC|BIOSENSOR|GROUNDWATER|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19214,"idioma_id":4,"titulo":"Adrenal steroids modulate the immune response during B. abortus infection by a mechanism that depends on the regulation of cytokine production","resumen":"Human brucellosis is a protean disease with a diversity of clinical signs and symptoms resulting from infection with Brucella species. Recent reports suggest a cross-regulation between adrenal steroids (cortisol and dehydroepiandrosterone [DHEA]) and the immune system. Monocytes and macrophages are the main replication niche for Brucella. Therefore, we investigated the role of adrenal hormones on the modulation of the immune response mediated by macrophages in B. abortus infection. Cortisol treatment during B. abortus infection significantly inhibits cytokine, chemokine, and MMP-9 secretion. In contrast, DHEA treatment had no effect. However, DHEA treatment increases the expression of costimulatory molecules (CD40, CD86), the adhesion molecule CD54, and major histocompatibility complex class I (MHC-I) and MHC-II expression on the surface of B. abortus-infected monocytes. It is known that B. abortus infection inhibits MHC-I and MHC-II expression induced by gamma interferon (IFN-&#947;) treatment. DHEA reverses B. abortus downmodulation of the MHC-I and -II expression induced by IFN-&#947;. Taken together, our data indicate that DHEA immune intervention may positively affect monocyte activity during B. abortus infection.","palabras_clave":"BRUCELLA ABORTUS|ADRENAL HORMONES|MONOCYTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19215,"idioma_id":4,"titulo":"TRENDS IN PREVALENCE OF HYPERTENSION IN ARGENTINA IN THE LAST 25 YEARS.  A SYSTEMATIC REVIEW OF OBSERVATIONAL STUDIES.","resumen":"Objective: We aimed to estimate the pooled prevalence of hypertension in Argentina and to analyze the trends in the level of awareness, treatment and control in the last 25 years.    Methods: A bibliographic search was conducted in MEDLINE, SCIELO and LILACS databases from 1988 to 2013. This study include population based studies and surveys in which prevalence of hypertension in adults were measured reported.   Results: Twenty peer reviewed publications were identified that reported the prevalence of hypertension over 33.397 patients. The crude hypertension prevalence reported from Argentina was 32.34% (95% CI: 30 ? 34.1%). The prevalence of hypertension in people aged 60 years and older was 71%. Only 12 studies assessed the levels of awareness, treatment and control of hypertension (57.9%, 49.5% and 20.5% respectively). The most prevalent cardiovascular risk factor was sedentary habits (54.4%), abdominal obesity (47%), overweight (43.1%), dyslipidemia (34.7%), smoking (27.4%) and diabetes (5.3%).  Conclusion: Hypertension is of public health importance in Argentina, with evidence of considerable under-diagnosis, treatment, and control. There is an urgent need to develop strategies to prevent, detect, treat, and control hypertension effectively in this region.","palabras_clave":"Epidemiology|Hypertension|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19216,"idioma_id":4,"titulo":"Landscape integration of North Patagonian mountain lakes: a first approach using characterization of dissolved organic matter","resumen":"North-western   Patagonia contains a variety of glacially formed mountain  lakes   located at different positions from the treeline in the Andean   Patagonian  forest region. Water chemistry of six North Patagonian lakes   located in an  altitudinal gradient, above, at and below the treeline   (~41°S) were analysed in  this study. The relative importance of   allochtonous to autochthonous carbon  inputs along a marked catchment   vegetation gradient encompassing altoandino  vegetation and Nothofagus   forests was addressed. The dissolved organic carbon  (DOC) concentration   varied among the study lakes, with the lakes located higher  in the   landscape exhibiting lower DOC concentrations (&lt;1 mg L_1) than lakes    located at or below the treeline (&gt;2 mg L_1). Analysis of coloured   and  fluorescent dissolved organic matter (CDOM and FDOM, respectively)   followed the  DOC pattern, despite the contrasting catchments of the   study lakes. The results  indicated the CDOM in all the lakes had low   molecular weight and low aromaticity.  The excitation?emission matrices   (EEMs) high- lighted three distinctive  fluorophores in the FDOM,   including two humic-like (peak A and peak C)  revealing the presence of   humic terrestrial material, and a protein-like  fluorophore (peak T)   generally associated with autochthonous DOM. The increased  intensities   of the humic fluorophores in the lakes located below the treeline    suggest higher allochtonous carbon inputs from their catchments. This   evidence  collectively suggests that mountain lakes exhibit some   heterogeneity in terms  of DOM, likely attributable to their position in   relation to the treeline,  which determines the contribution of the   catchment. As remote lakes are  extremely sensitive to changes in their   catchments, these North Patagonian mountain  lakes may accurately track   the impact of climate and anthropogenic changes on  the landscape.","palabras_clave":"DISSOLVED ORGANIC MATTER|FLUORESCENCE EXCITATION-EMISSION MATRix|MOUNTAIN LAKES|WATER CHEMISTRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19217,"idioma_id":4,"titulo":"Using Species Distribution Modeling to Assess Factors that Determine the Distribution of Two Parapatric Howlers (Alouatta spp.) in South America","resumen":"Through presence-only data, ecological niche modeling can use environmental variables to generate maps of areas that are potentially suitable for the presence of a species, improving our knowledge of its niche requirements and extending our understanding of its geographic distribution. We used the ecological niche model MaxEnt to predict the potential distribution of black-and-gold howlers (Alouatta caraya) and brown howlers (Alouatta guariba clamitans) in South America, as well as the potential sympatry area between both species. We modeled distributions of Alouatta caraya (196 presence localities, 8 bioclimatic variables) and A. guariba clamitans (74 presence localities, 13 bioclimatic variables) using bioclimatic variables from WorldClim with habitat suitability categorized as low, moderate, or high. Alouatta caraya showed a broader potential distribution, occupying a wide variety of habitats in a broad range of temperatures. Temperature annual range (Bio 7) was the bioclimatic variable with most influence in modeling the potential distribution of this species. Alouatta guariba clamitans was more restricted to rainy areas of mature forests at higher altitudes with low minimum temperatures. Mean temperature of coldest quarter (Bio 11) was the bioclimatic variable with the highest influence in this model. The predicted area of potential sympatry of both species was a relatively small area in the interior Atlantic Forest ecoregion, and a new syntopy locality occurred within the predicted area of sympatry. This narrow zone of overlap could be maintained, among other causes, by the role of the Paraná River as a natural barrier for dispersion, differences in niche requirements, potential interspecific competition, and hybridization.","palabras_clave":"ALOUATTA CARAYA|ALOUATTA GUARIBA CLAMITANS|MAXENT|POTENTIAL GEOGRAPHIC DISTRIBUTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19218,"idioma_id":4,"titulo":"Sr hexaferrite\/Ni ferrite nanocomposites: magnetic behavior and microwave absorbing properties in the X-band","resumen":"      Nickel ferrite nanoparticles were synthesized by a  self-combustion method over nanocrystalline powders of Nd-Co substituted  strontium hexaferrite with nominal composition Sr0.5Nd0.5Co0.5Fe10.5O19, at different  mass relations. The samples were structurally characterized by X-ray  diffractometry (XRD), scanning electron microscopy (SEM), and energy dispersive  X-ray analysis (EDX). The M vs. H loops of the composites were determined with  a vibrating sample magnetometer (VSM) and the interaction with the X-band  microwave radiation of the nanocomposites dispersed in epoxy resin was measured  with a vector network analyzer (VNA). The hysteresis loops showed strong  exchange-coupling between the two magnetic phases for the 30:70 and 50:50 Sr0.5Co0.5Nd0.5Fe10.5O19\/NiFe2O4nanocomposites,  while a weak interaction was observed for the 70:30 mass ratio. The  nanocomposite with an equal amount of hard and soft phase shows the highest  performance both in reflectivity and in bandwidth, reaching a maximum in reflectivity  of 34.4 dB at 11.1 GHz while the bandwidth below 10 dB is 3.5 GHz.  ","palabras_clave":"COMPOSITE MATERIALS|MAGNETIC MATERIALS|NANOSTRUCTURES|MICROWAVE ABSORPTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19219,"idioma_id":4,"titulo":"Magnetization mechanisms in ordered arrays of polycrystalline Fe100-x Cox nanowires","resumen":"Magnetization reversal processes and coercivity mechanisms in polycrystalline Fe100-x Cox nanowire arrays, resulting from an AC electrodeposition process, are investigated. The array coercivity is described on the basis of polarization reversal mechanisms operating in individual wires, under the effect of inter-wire dipolar interactions described by a mean field approximation. For individual wires, a reversal mechanism involving the nucleation and further expansion of domain-wall like spin configuration is considered. The wires have a mean grain size larger than both the nanowire diameter and the exchange length, so localized and non cooperative nucleation modes are considered. As the Co content increases, the alloy saturation polarization gradually decreases, but the coercive field and the relative remanence of the arrays increase, indicating that they are not controlled by the shape anisotropy in all the composition range. The coercive field dependence on the angle between the applied field and the wire long axis is not well described by reversal mechanisms involving nucleation and further displacement of neither vortex nor transverse ideal domain walls. On the contrary, the angular dependence of the coercive field observed at room temperature is well predicted by a model considering nucleation of inverse domains by localized curling, in regions smaller than the grain size, exhibiting quite small aspect ratios as compared to those of the entire nanowire. In arrays with higher Co contents, a transition from an initial (small angle) localized curling nucleation mechanism to another one, involving localized coherent rotation is observed at about pi\/4.","palabras_clave":"NANOWIRES|NUCLEATION|MAGNETIC ANISOTROPY|MAGNETIZATION MECHANISMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19220,"idioma_id":4,"titulo":"HAG3, a Histone Acetyltransferase, Affects UV-B Responses by Negatively Regulating the Expression of DNA Repair Enzymes and Sunscreen Content in Arabidopsis thaliana","resumen":"Histone acetylation is regulated by histone acetyltransferases and deacetylases. In Arabidopsis, there are 12 histone acetyltransferases and 18 deacetylases, histone acetyltransferases are organized in 4 families: the GNAT\/HAG, the MYST, the p300\/CBP and the TAFII250 families. Previously, we demonstrated that Arabidopsis mutants in the two members of the MYST acetyltransferase family show increased DNA damage after UV-B irradiation. To further investigate the role of other histone acetyltransferases in UV-B responses, a putative role of enzymes of the GNAT family, HAG1, HAG2 and HAG3, was analyzed. HAG transcripts are not UV-B regulated; however, hag3 RNAi transgenic plants show a lower inhibition of leaf and root growth by UV-B, higher levels of UV-B absorbing compounds and less UV-B induced DNA damage than Ws plants, while hag1 RNAi transgenic plants and hag2 mutants do not show significant differences with WT plants. Transcripts for UV-B regulated genes are highly expressed under control conditions in the absence of UV-B in hag3 RNAi transgenic plants, suggesting that the higher UV-B tolerance may be due to increased levels proteins that participate in UV-B responses. Together, our data provide evidence that HAG3, directly or indirectly, participate in UV-B induced-DNA damage repair and signaling.","palabras_clave":"histonas acetiltransferasas|UV-B|Arabidopsis|cromatina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19221,"idioma_id":4,"titulo":"First solid-state NMR spectroscopy evaluation of complexes of benznidazole with cyclodextrin derivatives","resumen":"Complexation of benznidazole (BZL), a drug of choice for the treatment of Chaga&#347;neglected disease, with cyclodextrin (CD) derivatives was analyzed by solid-state NMR. 13C cross polarization\/magic angle spinning spectra were recorded from BZL and from BZL:&#946;-CD, BZL:methyl &#946;-CD and BZL:hydroxypropyl &#946;-CD complexes, which were obtained by the solvent evaporation technique. No significant evidence was obtained on BZL inclusion complexes involving either &#946;-CD or hydroxypropyl &#946;-CD. Conversely, BZL:methyl &#946;-CD displayed BZL resonances characteristic of an amorphous drug and data analysis confirmed the presence of stable BZL:methyl &#946;-CD inclusion complexes, with benzene encapsulated into the host cavity. Further evidences on complex structure and dynamics were obtained from proton and carbon spin-lattice relaxation times in the rotating frame. These data are consistent with a common guest-host spin reservoir. The BZL interaction with methyl &#946;-CD provided a route to stabilize amorphous BZL. Physical mixtures with identical BZL and CD compositions were also studied for comparison.","palabras_clave":"SOLID STATE NMR|BENZNIDAZOLE|CYCLODEXTRINS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19222,"idioma_id":4,"titulo":"Counterclockwise post emplacement evolution of metatroctolites from Aluminé Igneous metamorphic Complex, neuquén Argentina","resumen":"Post-crystallization evolution of the metatroctolites of the Ñorquinco lake zone, Aluminé Igneous-Metamorphic Complex, is analyzed. These mafic rocks show coronas around olivine, composed of Opx, Cpx, Spl and Amp  (Hbl1and Hbl2). The temporal evolution of these rocks was evaluated via petrographic analysis and the construction of a suitable pseudosection based on the whole-rock chemical composition. This analysis was complemented with classic geothermobarometry, from which four stages on the P-T path were established: A. Starting point lies in the stability field of the Pl-Ol-Opx-Cpx-H2O, with P-T of 936 ºC and 2.7 kbar, respectively, indicative of granulite facies conditions;B. Another point in the trajectory is represented by first appearance of amphibole. P-T conditions for Hbl1-Pl are 780 °C and 5.9 Kbar, respectively.; C. The third point is characterized by the presence of Hbl2  and Spl and the disappearance of Ol, leading to the association Pl-Opx-Cpx-Hbl2-Spl-H2O. Equilibrium temperature and pressure for this stage are 780 ºC and 5.69 Kbar, respectively; and D. The last point in the path implies the disappearance of Cpx and the retrogression of the phases to Chl with, a concomitant consumption of excess water. Both the equilibrium temperature (694.2 ºC) for the stable association Pl-Opx-Hbl2-Spl-Chl, and the narrow stability pressure range (4.5-5.2 Kbar), are constrained by the absence of olivine and garnet. The defined portion of the P-T path indicates cooling from granulite to amphibolite facies with a concomitant pressure increment, defining a counter-clockwise P-T path. U-Pb zircon ages determined for basement xenoliths in metatroctolites and gabbroic inclusions in granodiorites, allows constraining the emplacement of Ñorquinco lake metatroctolites to Upper Paleozoic times.","palabras_clave":"metatroctolites|reaction coronas|geothermobarometry|P-T path"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19223,"idioma_id":4,"titulo":"Polyethylene film incorporation into the horticultural soil of small periurban production units in Argentina","resumen":"Horticulture makes intensive use of soil and extensive use of polyethylene (PE) sheeting and pesticides, producing an environment where the dynamics between soil and plastics can affect pesticide fate. We have determined that the presence of plastic residues in the horticultural soil of small production units equals 10 % of the soil area, being meso and macro-sections the predominant fragment sizes. All soil samples were taken from different plots located in Cuartel V, Moreno district, in the suburbs of Buenos Aires city, Argentina. Laboratory experiments were conducted to see the relations among pesticide, soil and PE film. Endosulfan recovery from LDPE films (25 mm and 100 mm) was studied, observing evidence that indicated migration to the inside of the plastic matrix. To further analyze the dynamics of pesticide migration to soil and atmosphere, experiments using chlopyrifos, procymidone and trifluralin were performed in soil-plastic-atmosphere microenvironments, showing that up to 24 h significant amounts of pesticides moved away from the PE film. To determine whether PE residues could act as potential pesticide collector in soil, column elution experiments were done using chlorpyrifos, procymidone and trifluralin. Results showed an important pesticide accumulation in the mulch film (584 mg-2284 mg pesticide\/g plastic) compared to soil (13 mg-32 mg pesticide\/g soil). Finally, chemical and photochemical degradation of deltamethrin adsorbed in PE film was studied, finding a protective effect on hydrolysis but no protective effect on photodegradation.             We believe that a deeper understanding of the dynamics among soil, plastic and pesticides in horticultural productive systems may contribute to alert for the implications of PE use for plastic sheeting.           ","palabras_clave":"Polyethylene film|Mulching|Greenhouses|Horticultural soil|Pesticides"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19224,"idioma_id":4,"titulo":"Overexpression of the carbohydrate binding module  of  strawberry expansin2 in Arabidopsis thaliana modifies plant  growth and  cell wall metabolism","resumen":"Several&nbsp; cell&nbsp; wall&nbsp; enzymes&nbsp; are&nbsp; carbohydrate&nbsp; active&nbsp; enzymes&nbsp; that&nbsp; contain&nbsp; a&nbsp; putative&nbsp; Carbohydrate Binding Module (CBM) in their structures. The main function of these non-catalitic modules is to facilitate&nbsp; the&nbsp; interaction&nbsp; between&nbsp; the&nbsp; enzyme&nbsp; and&nbsp; its&nbsp; substrate.&nbsp; Expansins&nbsp; are&nbsp; non-hydrolytic proteins present in the cell wall, and their structure includes a CBM in the C-terminal that bind to cell&nbsp; wall&nbsp; polymers&nbsp; such&nbsp; as&nbsp; cellulose,&nbsp; hemicelluloses&nbsp; and&nbsp; pectins.&nbsp; We&nbsp; studied&nbsp; the&nbsp; ability&nbsp; of&nbsp; the Expansin2 CBM (CBMFaEXP2) from strawberry (Fragaria x ananassa, Duch) to&nbsp; modify the cell wall&nbsp; of&nbsp; Arabidopsis&nbsp; thaliana.&nbsp; Plants&nbsp; overexpressing&nbsp; CBMFaEXP2&nbsp; were&nbsp; characterized phenotypically and biochemically. Transgenic plants were taller than wild type, possibly owing to a faster&nbsp; growth&nbsp; of&nbsp; the&nbsp; main&nbsp; stem.&nbsp; Cell&nbsp; walls&nbsp; of&nbsp; CBMFaEXP2-expressing&nbsp; plants&nbsp; were&nbsp; thicker&nbsp; and contained&nbsp; higher&nbsp; amount&nbsp; of&nbsp; pectins.&nbsp;&nbsp;&nbsp; Lower&nbsp; activity&nbsp; of&nbsp; a&nbsp; set&nbsp; of&nbsp; enzymes&nbsp; involved&nbsp; in&nbsp; cell&nbsp; wall degradation (PG, &#946;-Gal, &#946;-Xyl)&nbsp; was&nbsp; found,&nbsp; and&nbsp; the&nbsp; expression&nbsp; of&nbsp; the&nbsp; corresponding&nbsp; genes&nbsp; (AtPG, At&#946;-Gal, At&#946;-Xyl5)&nbsp; was&nbsp; reduced&nbsp; also.&nbsp; In&nbsp; addition,&nbsp; a&nbsp; decrease&nbsp; in&nbsp; the&nbsp; expression&nbsp; of&nbsp; two A.&nbsp; thaliana Expansin&nbsp; genes&nbsp; (AtEXP5 and AtEXP8)&nbsp; was&nbsp; observed.&nbsp; Transgenic&nbsp; plants&nbsp; were&nbsp; more&nbsp; resistant&nbsp; to Botrytis&nbsp; cinerea infection&nbsp; than&nbsp; wild&nbsp; type,&nbsp; possibly&nbsp; as&nbsp; a&nbsp; consequence&nbsp; of&nbsp; higher&nbsp; cell&nbsp; wall&nbsp; integrity. Our results support the hypothesis that the overexpression of a putative CBM is able to modify plant cell wall structure leading to modulation of wall loosening and plant growth. These findings might offer a tool to controlling physiological processes where cell wall disassembly is relevant, such as fruit softening. ","palabras_clave":"A. THALIANA|CARBOHYDRATE BINDING MODULE|CELL WALL|EXPANSIN|PECTIN|STRAWBERRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19225,"idioma_id":4,"titulo":"Postharvest senescence of florets from primary and secondary broccoli inflorescences","resumen":"The shelf-life of fresh-cut vegetables may be markedly affected by the type and quality of the raw  materials. In this work we evaluated the influence of the type of inflorescence used for processing  (primary and lateral) on the postharvest senescence of refrigerated fresh-cut broccoli. Florets from  primary and lateral heads were cut and washed with chlorinated water, rapidly cooled to 4 C, packed in  plastic trays covered with perforated PVC and stored at 4 C for 0, 14 or 21 d. During storage we evaluated  floret deterioration, respiration rate, weight loss, color, chlorophyll content, sugars (glucose, fructose and  sucrose), antioxidant capacity against ABTS+ and DPPH radicals, ascorbic acid and Folin?Ciocalteu-  reacting substances. Florets from lateral inflorescences were more perishable than fresh-cut broccoli  obtained from primary heads. Terminal  florets retained higher chlorophyll levels and showed delayed  yellowing. Already at harvest primary-broccoli showed lower respiration rate. Florets form terminal  heads showed lower weight and sugar loss during storage and maintained higher visual quality  throughout the storage period at 4 C. The inflorescence type also had large impact in the initial level of  antioxidants as well as in their metabolism during storage. This information may be useful for vegetable  processors.","palabras_clave":"Postharves|broccoli|senescence|chlorophyll"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19226,"idioma_id":4,"titulo":"Matching spatial scales of variation in mussel recruitment and adult densities across southwestern Atlantic rocky shores","resumen":"The recruitment of aquatic invertebrate larvae often differs in space and time thus contributing to variation in the abundance of adults. In the present study, we examined spatial scales of variation in mussel (Brachidontes spp.) recruitment and adult abundance across rocky intertidal areas in the Southwestern Atlantic. Recruitment and adult densities were compared between two regions separated ca. 700 km from each other, two locations (10?20 km from each other) within each region, and two sites (100?500 m from each other) within each location.Variance components analysis indicates that most variation in mussel recruitment and adult densities occurs at the scale of locations, irrespective of ifmussel recruitment is quantified onmussel bed samples or artificial substrates (plastic mesh collectors). Increased mussel recruitment and adult densities at this scale are associated with higher time-averaged chlorophyll a concentration andwave exposure,which can potentially affect the supply of larvae to rocky shores by increasing their survival and delivery rates. There was close correspondence between the spatial patterns of variation in cumulative recruitment on natural substrates during the study period and the density of adults at its end. This suggests that differences in mussel abundance along Southwestern Atlantic rocky shores could be primarily determined by larval recruitment.","palabras_clave":"INTERTIDAL|MUSSEL |RECRUITMENT|ROCKY SHORE|SOUTHWESTERN ATLANTIC|SPATIAL VARIATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19227,"idioma_id":4,"titulo":"A comparative study of Pleurosigma subrectum and P. acus (Bacillariophyta)","resumen":"In continuation of an earlier paper on Pleurosigma species with an (almost) non-sigmoid valve and raphe sternum, a comparative study was made in LM and SEM of Pleurosigma subrectum and P. acus. For P. subrectum, slides and a subsample of the type material were examined. For P. acus no unmounted material permitting SEM investigation is extant; a sample containing specimens fully matching the type in LM was therefore used as epitype material for SEM. The original data on striation of P. acus are emended. No morphological differences indicating separate specific status of these two taxa were observed and P. acus is therefore here designated a heterotypic synonym of P. subrectum. From the data now available, this is a very widely distributed species. The study demonstrates the indispensable role of collections for investigations on the diversity and distribution of diatom species.","palabras_clave":"Diatoms|Pleurosigma|P. acus|P. subrectum|taxonomy|Type material"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19228,"idioma_id":4,"titulo":"Valence fluctuations in a lattice of magnetic molecules: Application to iron(II) phtalocyanine molecules on Au(111)","resumen":"We study theoretically a square lattice of the organometallic Kondo adsorbate iron(II) phtalocyanine (FePc) deposited on top of Au(111), motivated by recent scanning tunneling microscopy experiments. We describe the system by means of an effective Hubbard-Anderson model, where each molecule has degenerate effective d-orbitals with xz and yz symmetry, which we solve for arbitrary occupation and arbitrary on-site repulsion U. To that end, we introduce a generalized slave-boson mean-field approximation (SBMFA) which correctly describes both the non-interacting limit (NIL) U = 0 and the strongly interacting limit $U   ightarrow infty$ , where our formalism reproduces the correct value of the Kondo temperature for an isolated FePc molecule. Our results indicate that while the isolated molecule can be described by an SU(4) Anderson model in the Kondo regime, the case of the square lattice corresponds to the intermediate-valence regime, with a total occupation of nearly 1.65 holes in the FePc molecular orbitals. Our results have important implications for the physical interpretation of the experiment.","palabras_clave":"Efecto Kondo|Fluctuaciones de valencia|Compuestos organometalicos en superficies|Microscopia de efecto tunel"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19229,"idioma_id":4,"titulo":"Mapping Antigenic Motifs in the Trypomastigote Small Surface Antigen from Trypanosoma cruzi","resumen":"The trypomastigote small surface antigen (TSSA) is a mucin-like molecule from Trypanosoma cruzi, the etiological agent of Chagasdisease, which displays amino acid polymorphisms in parasite isolates. TSSA expression is restricted to the surface of infectivecell-derived trypomastigotes, where it functions as an adhesin and engages surface receptors on the host cell as a prerequisitefor parasite internalization. Previous results have established TSSA-CL, the isoform encoded by the CL Brener clone, as an appealingcandidate for use in serology-based diagnostics for Chagas disease. Here, we used a combination of peptide- and recombinantprotein-based tools to map the antigenic structure of TSSA-CL at maximal resolution. Our results indicate the presenceof different partially overlapping B-cell epitopes clustering in the central portion of TSSA-CL, which contains most of the polymorphismsfound in parasite isolates. Based on these results, we assessed the serodiagnostic performance of a 21-amino-acidlongpeptide that spans TSSA-CL major antigenic determinants, which was similar to the performance of the previously validatedglutathione S-transferase (GST)-TSSA-CL fusion molecule. Furthermore, the tools developed for the antigeniccharacterization of the TSSA antigen were also used to explore other potential diagnostic applications of the anti-TSSA humoralresponse in Chagasic patients. Overall, our present results provide additional insights into the antigenic structure of TSSA-CLand support this molecule as an excellent target for molecular intervention in Chagas disease.","palabras_clave":"Trypanosoma cruzi|TSSA|mucin|antigen"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19230,"idioma_id":4,"titulo":"Multi-season Regional Analysis of Multi-species Occupancy: Implications for Bird Conservation in Agricultural Lands in East-Central Argentina","resumen":"Rapid expansion and intensification of agriculture create challenges for the conservation of biodiversity and associated ecosystem services. In Argentina, the total row crop planted area has increased in recent decades with the expansion of soybean cultivation, homogenizing the landscape. In 2003 we started the first long-term, large-scale bird monitoring program in agroecosystems of central Argentina, in portions of the Pampas and Espinal ecoregions. Using data from this program, we evaluated the effect of land use and cover extent on birds between 2003-2012, accounting for imperfect detection probabilities using aBayesian hierarchical, multi-species and multi-season occupancy model. We tested predictions that species diversity is positively related to habitat heterogeneity, which in intensified agroecosystems is thought to be mediated by food availability; thus the extent of land use and cover is predicted to affect foraging guilds differently. We also infer about ecosystem services provisioning and inform management recommendations for conservation of birds.Overall our results support the predictions. Although many species within each guild responded differently to land use and native forest cover, we identified generalities for most trophic guilds. For example, granivorous gleaners, ground insectivores and omnivores responded negatively to high proportions of soybean, while insectivore gleaners and aerial foragers seemed more tolerant. Habitat heterogeneity would likely benefit most species in an intensified agroecosystem, and can be achieved with a diversity of crops, pastures, and natural areas within the landscape. Although most studied species are insectivores, potentially beneficial for pest control, some guilds such as ground insectivores are poorly represented, suggesting that agricultural intensification reduces ecological functions, which may be recovered through management. Continuation of the bird monitoring program will allow us to continue to inform for conservation of birds in agroecosystems, identify research needed to reduce key uncertainties, and anticipate the effects of changes in agriculture incentral Argentina.","palabras_clave":"BIRDS|MONITORING|LAND USE|AGRICULTURE|ECOSYSTEM SERVICES|TRENDS|MANAGEMENT|CONSERVATION|ESPINAL|PAMPAS|BAYESIAN ANALYSIS|HIERARCHICAL MODELING|OCCUPANCY|COMMUNITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19231,"idioma_id":4,"titulo":"'Magnetite nanoparticles prepared by co-precipitation method in different conditions'","resumen":"Magnetic nanoparticles (MNPs) of pure magnetite (Fe3O4) were prepared in an aqueous solution (sample M&#8722;I) and in a water-ethyl alcohol mixture (sample M&#8722;II) by the co-precipitation method. The structure and magnetic properties of both samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), magnetic (M&#8722;H) and microwave measurements (FMR). The mean average particle diameter and particle size distribution was evaluated by the Dynamic Light Scattering (DLS) and Brunauer- Emmett-Teller techniques (BET). The Quantitative chemical analysis of iron was performed by Inductively Coupled Plasma (ICP)- Atomic Emission Spectroscopy (AES) technique. The MNPs prepared in aqueous solution show a higher grain than those prepared in the water-ethyl alcohol mixture. The type of phase structure in both cases can be defined as ?defective spinel?. The shape of the majority of M&#8722;I MNPs is octahedral. The shape of the majority of M&#8722;II MNPs is cubic. The specific surface area of MNPs was as high as 14.4 m2\/g for M&#8722;I sample and 77.8 m2\/g for sample M?II. The obtained saturation magnetization values of 75 emu\/g (M&#8722;I) and 68 emu\/g (M&#8722;II) are consistent with expected values for magnetite MNPs of observed sizes. Ferromagnetic resonance (FMR) measurements confirmed that MNPs of both types are magnetically homogeneous materials. FMR lines´ position and line widths can be understood by invoking the local dipolar fields, deviations from sphericity, magnetocrystalline anisotropy and stresses. M&#8722;I sample shows sizeable zero field microwave absorption which is absent in the M&#8722;II case. The differences in microwave behaviour of M&#8722;I and M&#8722;II MNPs can be used in the design of microwave radiation absorbing multilayers.","palabras_clave":"Magnetic materials|Nanostructures|Chemical synthesis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19232,"idioma_id":4,"titulo":"Screen-printed electrodes modified with carbon nanotubes or graphene for simultaneous determination of melatonin and serotonin","resumen":"Single-walled carbon nanotubes (SWCNT), multiwalledcarbon nanotubes (MWCNT) and graphene havebeen tested as carbon allotropes for the modification of carbonscreen-printed electrodes (CSPEs) to simultaneously determinemelatonin (MT) and serotonin (5-HT). Two groupsof CSPEs, both 4 mm in diameter, were explored: The firstincludes commercial SWCNT, MWCNT and graphene, thesecond includes SWCNT, MWCNT, graphene oxidenanoribbons and reduced nanoribbons that were drop castedon the electrodes. The carbon nanomaterials enhanced theelectroactive area in the following order: CSPE ","palabras_clave":"Screen-printed electrode|Carbon nanomaterials|Single andmulti-walled carbon nanotubes|Graphene"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19233,"idioma_id":4,"titulo":"Confined Gold Nanoparticles Enhance the Detection of Small Molecules in Label Free Impedance Aptasensors.","resumen":"A controlled architecture of nanoelectrodes, of a similar size to small molecule-binding aptamers, is synthesized inside nanoporous alumina. Gold nanoparticles with a controlled size (about 2 nm) are electrogenerated in the alumina cavities, showing a fast electron transfer process toward ferrocyanide. These uncapped nanoparticles are easily modified with a thiol-containing aptamer for label-free detection of adenosine monophosphate by electrochemical impedance spectroscopy. Our results show that the use of a limited electrical conducting surface inside an insulating environment can be very sensitive to conformational changes, introducing a new approach to the detection of small molecules, exemplified here by the direct and selective detection of adenosine monophosphate at the nanomolar scale.","palabras_clave":"NANOELECTRODES|APTASENSORS|ELECTROCHEMISTRY|EXAFS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19234,"idioma_id":4,"titulo":"Exploring the Use of a Guanine-Rich Catalytic DNA for Sulfoxide Preparation","resumen":"A guanine-rich DNA oligonucleotide complexed with heminwas used to catalyze controlled oxygen transfer reactions to different sulfidesfor sulfoxide preparation in the presence of H2O2.Comparable activities were obtained when using fully modified L-DNA. Inaddition, oligonucleotide immobilization led to an active catalyst which couldbe successfully recovered and reused without loss of activity. ","palabras_clave":"DNAZYMAS|SULFOXIDES|OXIDATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19235,"idioma_id":4,"titulo":"Molecular typing of Argentinian Mycobacterium avium subsp. paratuberculosis isolates by multiple-locus variable number-tandem repeat analysis","resumen":"Multiple-locus variable number-tandem repeat analysis (MLVA) of Mycobacterium avium subspecies paratuberculosis (MAP) isolates may contribute to the knowledge of strain diversity in Argentina. Although the diversity of MAP has been previously investigated in Argentina using IS900-RFLP, a small number of isolates were employed, and a low discriminative power was reached. The aim of the present study was to test the genetic diversity among MAP isolates using an MLVA approach based on 8 repetitive loci. We studied 97 isolates from cattle, goat and sheep and could describe 7 different patterns: INMV1, INMV2, INMV11, INMV13, INMV16, INMV33 and one incomplete pattern. INMV1 and INMV2 were the most frequent patterns, grouping 76.3% of the isolates. We were also able to demonstrate the coexistence of genotypes in herds and co-infection at the organism level. This study shows that all the patterns described are common to those described in Europe, suggesting an epidemiological link between the continents.","palabras_clave":"PARATUBERCULOSIS|MOLECULAR TYPING|MIRU-VNTR|MLVA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19236,"idioma_id":4,"titulo":"Full-state feedback equivalent controller for active damping in LCL filtered Grid Connected Inverters using a reduced number of sensors","resumen":"This paper presents a method for the active damping of a grid-tie LCL inverter. This method is based solely on the feedback of the injected current into the grid, and is applicable to any linear current controller. It requires a low additional computational load over that required to control a grid-tie L inverter, and the same measurements. A general design methodology for the current controller, which allows positioning all the closed loop poles of the system at arbitrary locations (even unstable modes of the LCL filter), is proposed. Stability and robustness of the resulting system is analyzed. Simulation and experimental results that validate the proposal are presented.","palabras_clave":"LCL filter|Resonance Damping|Active Damping"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19237,"idioma_id":5,"titulo":"ESTUDIO EXPERIMENTAL SOBRE LA DINÁMICA POSTDEPOSITACIONAL EN RASTROS DE USO: INTEGRIDAD ARTEFACTUAL DEL COMPONENTE 1 DE CUEVA MARIPE (SANTA CRUZ, ARGENTINA)","resumen":"Los materiales recuperados de excavaciones arqueológicas han sido afectados por diversos procesos post-depositacionales; ya sea de carácter natural como así también antrópico. Estos procesos ocasionan traslados y reorganización de los objetos alterando, en gran medida, la integridad de los mismos. En tal sentido, la evaluación de los múltiples procesos culturales y naturales que intervienen en la formación de los depósitos arqueológicos, es una herramienta fundamental para inferir las condiciones que contribuyeron a la formación de los sitios arqueológicos en general. Los objetos líticos tallados son el indicio material, a partir del cual, se puede comenzar el estudio de los procesos de formación y comportamiento del registro arqueológico mediante análogos experimentales. En este sentido, el objetivo del trabajo ha sido profundizar los conocimientos acerca de estos procesos y de su accionar sobre los rastros de uso detectados en los artefactos líticos del sitio arqueológico Cueva Maripe (Santa Cruz, Argentina), con ocupaciones humanas desde inicios del Holoceno. La acción del agua como agente corrosivo pudo haber influenciado las modificaciones de las superficies y filos del material lítico, afectando diferencialmente el grado de preservación de los microrrastros en los distintos sectores de la cueva. Para evaluar la variabilidad funcional de artefactos, presentamos los resultados obtenidos de la aplicación de dos vías analíticas independientes: análisis funcional y análisis diatomológico.","palabras_clave":"Cazadores-recolectores| procesos post-depositacionales|análisis funcional |diatomeas."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19238,"idioma_id":5,"titulo":"Estrategias bacterianas de supervivencia como herramientas en Biotecnología Ambiental","resumen":"Las diversas actividades humanas, desde industriales hasta   agropecuarias, generan desechos que al ser vertidos al ambiente provocan   serios desequilibrios en los diversos ecosistemas. Las comunidades   microbianas son las involucradas en la recuperación de suelos y cuerpos   de agua gracias a su versatilidad de respuestas. Pseudomonas veronii   2E es una bacteria aislada a partir de sedimentos del río Reconquista,   el curso de agua más importante de la zona noroeste del Área   Metropolitana de Buenos Aires, cuya cuenca recibe las descargas de las   principales actividades industriales y agropecuarias de la zona. El   objetivo general de nuestro proyecto es explotar las estrategias   adaptativas de P. veronii 2E para el desarrollo de sistemas de   tratamiento de efluentes industriales. Algunas de estas estrategias   aplicables a la biotecnología ambiental son: su capacidad de formación   de biopelículas, la reducción microbiana de Cr(VI) y la producción de   sideróforos.","palabras_clave":"biotratamiento|efluentes de galvanoplastías|interacciones metal-microorganismos|Pseudomonas veronii."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19239,"idioma_id":4,"titulo":"Digestive flexibility in a euryhaline crab from a SW Atlantic coastal lagoon: alkaline phosphatase activity sensitive to salinity in the hepatopancreas","resumen":"We studied biochemical characteristics and the response to low salinity at short and long-term after feeding of alkaline  phosphatase (AP) activity in hepatopancreas of the osmoregulator crab Neohelice granulata from Mar Chiquita coastal  lagoon (Buenos Aires Province, Argentina) (37832&#8242; ?37845&#8242;S 57819&#8242; ?57826&#8242;W). The hepatopancreas exhibited a  levamisole-insensitive and a levamisole-sensitive AP activity with distinct characteristics. Levamisole-insensitive activity  was similar within the range of pH 7.4?9.0 and exhibited a Michaelis?Menten kinetics. Levamisole-sensitive AP activity  appeared to be maximal at pH 8.5 and appeared to exhibit an allosteric kinetics. In crabs acclimated to 10 psu (hyperregulation  conditions) levamisole-insensitive and levamisole-sensitive AP activity increased (about 16-fold) over time from  short term (2?4 h) to long term (120 h) after feeding while no changes occurred in crabs acclimated to 35 psu (osmoconforming  conditions). The changes of AP activity along with the higher values at 120 h after feeding in 10 psu compared with those  in 35 psu, and the concomitant changes in proteolytic activity, suggest a role of AP in digestive and metabolic adjustments at  the biochemical level upon hyper-regulatory conditions.","palabras_clave":"Digestive flexibility|Alkaline phosphatase,|Hepatopancreas|Crabs"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19240,"idioma_id":4,"titulo":"The Early Cretaceous Megaflora of the Springhill Formation, Patagonia. Paleofloristic and Paleonvironmental Inferences","resumen":"The Springhill Formation (Lower Cretaceous) is considered as one of the most important oil producer units within the Austral Basin in Argentina. However, knowledge regarding this formation?s plant community composition is still very scarce. In this work a thorough survey of the outcrops of the Springhill Formation was conducted regarding both geological and paleobotanical aspects. Abundant fossil plant material was collected at the Estancia El Salitral and Río Correntoso localities in Santa Cruz Province, Argentina, consisting primarily of compressions of leafy shoots with several branching orders, completely to partially preserved fronds, simple to pinnate leaves and fertile scales. Analysis of these materials made it possible to describe 20 new taxa which add to the already known flora of the Springhill Formation; nine of these taxa were found in Estancia El Salitral, and the remaining 11 were found in Río Correntoso. The floristic diversity of the unit has increased through the discovery of the first megafossils of ginkgophytes (Baiera sp. 1 and Baiera? sp. 2), whereas new taxa have been described within the divisions of Pteridophyta, Pteridospermophyta, Cycadophyta and Pinophyta. Analysis of the vegetative and reproductive epidermal structures of the various groups included within this megaflora has been demonstrated to be a valuable tool for the recognition and differentiation of species. Analysis has also made it possible to suggest paleoenvironmental inferences. Finally, the megaflora from the Springhill Formation was compared to other relevant plant assemblages from the Lower Cretaceous of Western Gondwana. The megaflora was determined to be most similar to that of the well-known Patagonian Anfiteatro de Ticó Formation and most different from that of the Brazilian Crato Formation.","palabras_clave":"Megaflora|Cuticle|Springhill Formation|Paleoenvironment|Lower Cretaceous|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19241,"idioma_id":4,"titulo":"Detection and location of Lr11 and other leaf rust resistance genes in the durably resistant wheat cultivar Buck Poncho","resumen":"Three race-specific genes were identified in a  cross between the durable leaf rust resistant wheat cultivar Buck Poncho (BP)  and the leaf rust susceptible cultivar Purple Straw (P). Two seedling  resistance genes, temporarily named LrBP1  and LrBP2, and one adult plant  resistance gene named LrBP3 were  identified. Multi-pathotype tests on seedlings of BP and Thatcher near-isogenic  lines carrying single resistance genes indicated that Lr10 and Lr11 were  candidates for LrBP1 and LrBP2, respectively. The identification  of LrBP1 as Lr10 was corroborated by markers previously reported to be linked  to Lr10. LrBP2 was linked to 12 markers located on the short arm of  chromosome 2D, the closest of which was SCAR32\/35 at 0.3 cM. Lr11 was previously located in  chromosome 2A, but monosomic analysis and telocentric mapping indicated that Lr11 was distally located in chromosome  2DS. The presence of the expected PCR fragment of SCAR32\/35 in BP and wheat  lines carrying Lr11, and results from  an allelism test between a stock carrying LrBP2  with one carrying Lr11, indicated  that these two genes are more likely the same. Thirteen markers located in  chromosome 6A were loosely linked to LrBP3.  Lines carrying the three resistance genes were evaluated for leaf rust response  in the field. None of the gene combinations showed infection severities as low  as BP, indicating that the three genes only partially explained the observed  level of resistance in BP.","palabras_clave":"BUCK PONCHO|LINKAGE MAPS|LR11|PUCCINIA TRITICINA|TRITICUM AESTIVUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19242,"idioma_id":4,"titulo":"Muscular anatomy of the forelimbs of the lesser grison (Galictis cuja), and a functional and phylogenetic overview of Mustelidae and other Caniformia","resumen":"The extrinsic and intrinsic forelimb musculature of the lesser grison (Galictis cuja), a short-legged mustelid of southern South America, is studied for the first time. We present descriptions, muscular maps, and weight data. Muscular anatomy description of the lesser grison provides the framework for discussing the myological diversity of  mustelids and other caniforms, for addressing nomenclatural problems (such as synonymy and homonymy), and for highlighting some functional and phylogenetically informative traits.We recognize in the lesser grison features shared by all mustelid species, and some other caniforms, especially mephitids, such as the presence of rhomboideus profundus, an angular head of triceps brachii, and, apparently, the absence of a flexor digitorum brevis manus. An unexpected record of articularis humeri, a proximal origin of the brachioradialis, and the absence of the tensor fascia antebrachii are recorded for this species. As other ictonychines and mustelines, Galictis cuja possesses stronger and subdivided protractors and sagittal rotators of the forelimbs, as well as shoulder and elbow extensors. These features allow for resistance in landing during bounds and increase the stride length during epigean and subterranean crouched locomotion. Powerful neck musculature assists during hunting and carrying of prey. Weakness of some retractors and intrinsic flexors is related to a relatively minor importance of the forelimbs as propellers during bounding and the lack of other specializations. The configuration of the rhomboideus and the absence of coracobrachialis seem to be informative at the subfamiliar level within Mustelidae. The comprehensive and comparative review of available information leads us to propose possible solutions to old nomenclatural problems and of identification. This allows us to reassess of some myological features as diagnostic of caniform clades.","palabras_clave":"Caniformia|Forelimb|Galictis|Mustelidae"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19243,"idioma_id":4,"titulo":"Reading shell shape: implications for palaeoenvironmental reconstructions. A case study for bivalves from the marine Quaternary of Argentina (South Western Atlantic).","resumen":"Most research on bivalves from the south-western Atlantic used morphological (shell) characters for taxonomic discriminations. Dominant Veneroids from Argentinian Quaternary coastal deposits exhibit wide morphological variation ? often making objective discriminations difficult\/impossible, which could be objectively described and compared through geometric morphometrics techniques. This work focuses on comparison of geometric morphometrics methods applied to fossil and modern shells, to assess inter- and intra-generic variations. Three approaches were considered: landmarks (L), semi-landmarks (SL) and outlines. Shell shape analyses for different time spans (Pleistocene, fossil Holocene and modern) and areas (Patagonia and Bonaerensian) showed that Elliptic Fourier analysis (EFA), Landmarks and Landmarks plus Semilandmarks (L+SL) can discriminate at generic levels: Mactra, Mulinia (Mactridae) vs. Pitar, Protothaca, Eurhomalea, Clausinella (Veneridae). L and L+SL are powerful for inter\/intraspecific distinctions of Mactra. Variability of Mactra isabelleana includes the remaining nominal ?species? (transitional morphs). Causal environmental factors of (phenotype) variation could be addressed for modern environments (substrate, salinity and energy). Subtrigonal-inflated shells predominate in muddy, quieter, shallow mixo-polyhaline waters; ovate-elongate-compressed in sandy, poly-euhaline, deeper habitats. Differential spatial distribution (and abundance) across time responds to Late Quaternary high sea-level stands: transgressive maxima allowed higher salinity in marginal-marine areas and optimal conditions for Mactra isabelleana contrasting with scarcer records in the Mar Argentino today.","palabras_clave":"MOLLUSCS|HOLOCENE|PLEISTOCENE|GEOMETRIC MORPHOMETRICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19244,"idioma_id":4,"titulo":"First approach to the paleobiology of extinct Prospaniomys (Rodentia, Hystricognathi, Octodontoidea) through head muscle reconstruction and the study of cranio-mandibular shape variation","resumen":"?Prospaniomys is a basal octodontoid recorded in  the early Miocene in Patagonia (Argentina; Colhuehuapian  SALMA). Nearly complete cranial and mandibular remains  known for this genus provide a unique opportunity to explore  its paleobiology. For this, masticatory muscles were reconstructed  and craniomandibular shape variation assessed.  While such reconstruction indicates that most masticatory  muscles would have presented moderate development, both  the masseter lateralis and posterior muscles were poorly developed.  In contrast, we found that the temporalis muscle was  well developed, while conspicuous postorbital constriction,  postorbital processes, and superior temporal lines revealed a  substantial orbital portion of this muscle. According to geometric  morphometric results, craniomandibular shape was  interpreted as generalized. Features such as shortened palate,  narrower bizygomatic width, orthodont incisors, enlarged  incisive foramina, and a shallow jaw could be linked to  epigean habits. The moderate development of auditory bullae  in Prospaniomys suggests that it is unlikely that it may  have lived in extreme arid environments. Additionally,  based on its generalized dental morphology, an omnivorous or  generalized herbivorous diet that may have included leaves,  fruit, and potentially animal matter was inferred. By the early  Miocene, Patagonia experienced the initial expansion stage of  arid-adapted vegetation, with grasses present in low amounts  and abundant forests. Generalized habits and soft and nonabrasive  diet suggest that Prospaniomys was possibly associated  with more closed environments. Morphology alone cannot  be used as an environmental proxy, but it could undoubtedly  contribute to the interpretations based on data provided by  paleobotanical and geological frameworks in studies on the  evolution of environments.","palabras_clave":"Geometric morphometrics|Masticatory muscles|Caviomorphs|early Miocene"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19245,"idioma_id":4,"titulo":"The role of evolutionary integration in the morphological evolution of the skull of caviomorph rodents (Rodentia: Hystricomorpha)","resumen":"The mammalian cranium is a complex structure composed by three partially independent modules: face, cranial base and cranial vault. At the same time, it interactswith the mandible by sharing the masticatory function. Since these units develop and work together, their function and evolution may occur through correlated changes. Here, weassessed the patterns of evolutionary shape variation and covariation (i.e. integration) of cranial modules and mandible among the highly ecomorphologically diversecaviomorph rodents, and the potential evolutionary consequences on the morphological evolution of this clade. Three dimensional geometric morphometrics was used to describecranio-mandibular shape. The phylogenetic signal and evolutionary allometric component of morphometric variables were analyzed; in addition, evolutionary covariation amongcranial modules and mandible was assessed using phylogenetic comparative methods. Significant phylogenetic signal and evolutionary allometry were detected. Large covariancevalues, involving coordinated breadth increase as the main shape change, were recorded between cranial vault and base, followed by cranial vault and face, and face and mandible.Since the basicraniummay be the main cranial integrator, the overall widening of the cranial base, derived from the enlargement of the auditory bullae, could be influencing the integrated evolution of skull. In caviomorphs, the craniomandibular morphological evolution would be the outcome of a tight covariation among the modular units, and this could be driven by several factors such as allometry and specializations to environmental niches.","palabras_clave":"Caviomorph rodents|Evolutionary allometry|Morphological integration"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19246,"idioma_id":4,"titulo":"Comparison of different fertilisation media for an in vitro maturation-fertilisation-culture system using flow-cytometrically sorted X chromosome-bearing spermatozoa for bovine embryo production","resumen":"High demand exists for in vitro-derived bovine embryos fertilized with female sex-sorted sperm by high value breeding stock among commercial cattle producers. This study was conducted to evaluate three fertilization media: M199, synthetic oviductal fluid (SOF) and Tyrode´s Albumin-Lactate-Pyruvate (TALP) on in vitro fertilization (IVF) performance using female sex-sorted sperm. A total of 1,143, 1,220 and 1,041 cumulus-oocyte complexes were fertilized in M199, SOF and TALP, respectively. Cleavage (M199=57%, SOF=71% and TALP=72%), blastocyst formation (M199=9%, SOF=20% and TALP=19%), proportion of grade 1 blastocysts (M199=15%, SOF=52% and TALP=51%), proportion of grade 3 blastocysts (M199=58%, SOF=21% and TALP=20%), and hatching rates (M199=29%, SOF=60% and TALP=65%) were significantly (p","palabras_clave":"INVITRO|FERTILIZATION|EMBRYO|BOVINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19247,"idioma_id":4,"titulo":"Llama (Lama glama) semen collection via thermo-electric artificial vagina: Effect of seasonality and collection interval on ejaculate characteristics","resumen":"Adult male Llamas (Lama glama) (n = 6) were collected using a receptive female and a thermo-electric artificial vagina assembled with a polyethylene collection bag with the following objectives: a) to develop a reliable and repeatable semen collection technique for Llama, b) validate semen evaluation tests for Llama, and c) to determine the effect of collection frequency and season on Llama semen characteristics. First, the semen and sperm variables were recorded and validated through their own repeatability. Semen collection intervals tested were: 1X\/week during three weeks and 3X\/week during another three weeks, the second collection period occurring after two weeks of sexual rest. The collection frequency of 3X\/week significantly reduced (P&lt;0.05) the sperm viability, motility, concentration, Total Sperm\/Ejaculate, Total Motile Sperm\/Ejaculate and Total Live Sperm\/Ejaculate, but improved Total Sperm\/Week and Total Live Sperm\/Week. All recorded variables were significantly higher during summer in comparison to spring with the exception of morphology abnormalities, volume, and viability. Also, the 1X\/week versus the 3X\/week semen collection frequencies did not produce a significant difference in the percent of total motile sperm\/week. Based on semen and sperm characteristics evaluated herein, Llama semen collected in the summer time was better (P &lt; 0.05), with regard to the majority of the variables analyzed, than semen collected in the spring. ","palabras_clave":"LLAMA|SEMEN|COLLECTION|EVALUATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19248,"idioma_id":4,"titulo":"MORPHOLOGY AND ULTRASTRUCTURE OF SCHIZAEA FISTULOSA (SCHIZAEACEAE) SPORES FROM CHILE.","resumen":"Resumen: Morfología y ultraestructura de las esporas de Schizaea fistulosa (Schizaeaceae) de Chile. Se estudiaron las esporas de Schizaea fistulosa de Chile con microscopía óptica (MO), electrónica de barrido(MEB) y transmisión (MET). Las esporas son monoletes y elípticas en vista polar. El diámetro ecuatorial mayor es de 71-85 &#956;m y el diámetro polar de 54-61 &#956;m. Las lesuras son de 50-60 &#956;m de longitud y en algunos casos están bifurcadas. La ultraestructura de la esporodermis se describe por primera vez. El exosporio en sección posee dos capas y es verrucoso-tuberculado con elementos aislados o fusionadosformando lomos cortos. El perisporio posee una sola capa, de 10-30 nm de espesor y solamente es visible con microscopía electrónica de transmisión. Sobre la superficie de la espora, se observan numerosos esferoides y nanoesferoides de diferentes tamaños, adheridos a la superficie. Se discuten los resultados y se los compara con estudios previos en Schizaea.","palabras_clave":"Schizaea fistulosa| spores| morphology|ultrastructure"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19249,"idioma_id":4,"titulo":"Outcomes of competitive interactions after a natural increment of resources: the assemblage of aphid-tending ants in northern Patagonia","resumen":"Ant-aphid relationships provide excellent opportunities to study how changes in resource availability may affect the outcome of competitive interactions. Variations in soil fertility may affect host plant quality, with concomitant effects on aphid abundance and the amount\/quality of aphid honeydew. This may determine the intensity at which tending ants defend aphids against natural enemies and competing ants. In a shrub-steppe of northern Patagonia, aphid-infested thistles naturally grow on contrasting fertility substrates: organic waste piles of leaf-cutting ants (refuse dumps) and nutrient-poor steppe soils. Thistles growing on refuse dumps have much larger aphid colonies than thistles growing on steppe soils. We took advantage of the co-occurrence in the field of plants with contrasting aphid density to study the effect of natural variation in food availability (aphid density) on aphid-tending ant species richness and agonistic interactions among them. Enhanced aphid density did not promote the coexistence of aphid-tending ant species. Although all ant species are potential colonizers of the study plants, thistles were often monopolized by a single ant species, regardless of aphid density. Field experiments showed that increased aphid density did not modify aggressiveness toward an intruder ant, nor the probability of coexistence between two rival ant species after the invasion of a host plant. We discuss several hypotheses to explain why increased resource availability does not necessarily reduce competitive interactions in ant-aphid relationships.","palabras_clave":"Aggressive behavior|Ant communities|Competitive interactions|Resource availability"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19250,"idioma_id":4,"titulo":"Climate change and lizards: changing geographic range in Patagonia","resumen":"Ectothermic organisms strongly depend on temperature, making them an27 excellent model to study the impact of Global Climatic Change (GCC). Under global28 warming, species may be forced to move toward colder environments, such as higher29 latitudes, higher elevations or both. However, several studies show that responses may30 vary significantly in different groups of species. Therefore, it is unclear if species´31 current distribution range sizes will be affected in future climatic scenarios. In addition32 to the specific possible effect of range size changes, the potential consequences of33 distributional range shifts also should be considered. Here, our aim is to assess whether34 GCC may affect a group of Liolaemus lizard species based on their current geographic35 distribution range size and if the effect is uniform across all species using Species36 Distribution Models (SDMs). Our results show that range boundaries of the fourteen37 species switch toward higher altitude and latitude in future scenarios. Additionally, there38 is not a unique pattern in terms of increase or decrease in potential range for lizards in39 Patagonia in future scenarios. Finally, our results show that the original distribution40 range size is determinant for the resultant SDMs projections, suggesting that species41 with a high degree of endemicity may be susceptible to a greater impact of GCC.","palabras_clave":"Patagonia|Lizards|Species distribution models|Liolaemus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19251,"idioma_id":4,"titulo":"'Thermal and mechanical properties of commercial MgO-C bricks'","resumen":"MgO-C (magnesia-carbon) refractories are widely used in several steelmaking linings. These refractories are exposed to extreme stress due to high temperatures (T > 1600 °C) required to cause the metallurgical reactions. These working conditions produced refractory wear through various related processes. The different types of degradation that the material suffers can be from thermochemical or thermomechanical origin. In this work, the Young's modulus, the fracture resistance and the thermal expansion coefficient of three commercial magnesia-carbon bricks (A, B, and C) were measured to evaluate their resistance to thermomechanical degradation. These data provided an estimation of the thermomechanical stresses that they can withstand. According to the results, the lowest fracture toughness is developed by brick C. This behavior is associated to a higher porosity and quality of the binder and magnesia used. Furthermore, while the brick B has the highest resistance to crack initiation due to thermal shock, the brick A proves to be the most suitable, taking into account the relationship between resistance to the initiation and propagation of cracks. A greater degree of strain to the level of the fracture stress is also presented in the bricks A and B. This is connected to their higher content of graphite (9-12 %) compared to brick C (~ 4 %).","palabras_clave":"REFRACTORIES|MgO-C|MECHANICAL PROPERTIES|THERMAL PROPERTIES|MICROSTRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19252,"idioma_id":4,"titulo":"A new way of quantifying the production of poly(hydroxyalkanoate)s using FTIR","resumen":"Conventional techniques used for determination of extractable poly(hydroxyalkanoate)s (PHAs) present in cells are laborious and destructive. Fourier transform infrared (FTIR) spectroscopy is an indirect analytical method to study molecular structures and has been used for the detection and quantification of PHA in intact cells. However, obtain a fine powder with pure PHA to prepare KBr pellets is a difficult task. The objective of this study was to develop a cheap alternative for quantifying the extractable intracellular PHA, based on a pulverizable solid as a standard material (PEM: Pre Extraction Material) produced by Bacillus megaterium BBST4 strain, instead of pure PHA produced by the same strain. Through statistical analysis the correlation between sample content and its FTIR spectra were determined. The proposed methodology employs typical MID-FTIR equipment and KBr pellets for spectra determination.","palabras_clave":"poly(hydroxyalkanoate)s|quantification|Bacillus megaterium"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19253,"idioma_id":4,"titulo":"Global change effects on biogeochemical processes of Argentinian estuaries: an overview of vulnerabilities and ecohydrological adaptive outlooks","resumen":"The aims of this work are to provide an overview of the current stresses of estuaries in Argentina and to propose adaptation strategies from an ecohydrological approach. Several Argentinian estuaries are impacted by pollutants, derived mainly from sewage discharge and agricultural or industrial activities. Anthropogenic impacts are expected to rise with increasing human population. Climate-driven warmer temperature and hydrological changes will alter stratification, residence time, oxygen content, salinity, pollutant distribution, organism physiology and ecology, and nutrient dynamics. Good water quality is essential in enhancing estuarine ecological resilience to disturbances brought on by global change. The preservation, restoration, and creation of wetlands will help to protect the coast from erosion, increase sediment accretion rates, and improve water quality by removing excess nutrients and pollutants. The capacity of hydrologic basin ecosystems to absorb human and natural impacts can be improved through holistic management, which should consider social vulnerability in complex human-natural systems.","palabras_clave":"POLLUTANTS|NUTRIENTS|EXOTIC SPECIES|ADAPTATION|WETLANDS|ECOHYDROLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19254,"idioma_id":4,"titulo":". Insights on ecological and reproductive aspects of two cryptogenic peracarid crustaceans from Argentinean coasts.","resumen":"Peracarid crustaceans belong to the most important agglomerating macrofauna in sedimentary habitats. The amphipod Monocorophium insidiosum Crawford, 1937 and  the tanaid Tanais dulongii Audouin, 1926 are listed as invasive species. In the present study we investigated the ecology of M. insidiosum and T. aff. dulongii at the Argentinean coast. We breeded both crustaceans to study their fecundity and growth, and investigated their behavior and potential interspecific  relations in four different laboratory experiments. We evaluated tube  building capabilities (experiment 1), and tested gender specific responses of M. insdiosum to empty (experiment 2 and 3), and housed T. aff. dulongii tubes (experiment 4). Our results showed a high fecundity (three generations within four weeks) and growth rates (duplication of body lengths in two weeks) for M.  insidiosum. Two tube construction strategies were distinguished: a tube changing behavior for M. insidiosum, showing higher construction activities for  females, and a tube keeping behavior for T. aff. dulongii. Overall tanaid tubes were frequently claimed by M. insidiosum demonstrating a close interspecific relation and resulting in decreased sediment aggregating activity. Due to our observations it is likely that these invasive species are frequently distributed along the Patagonian Atlantic coast and will spread in future.","palabras_clave":"MONOCOROPHIUM INSIDIOSUM|TANAIS AFF: DULONGII|AMPHIPODS|EPIBENTHOS|NORTH PATAGONIA|ALGAL-CRUSTACEAN INTERACTIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19255,"idioma_id":4,"titulo":"Aggregation dynamics and magnetic properties of magnetic micrometer-sized particles dispersed in a fluid under the action of rotating magnetic fields","resumen":"We present a dynamic study of soft magnetic, commercial Fe and Ni micrometer-sized particles dispersed in oleic acid and subjected to a variable (rotating) magnetic field in the horizontal plane. A very complex structure is formed after the particles decant towards the bottom liquid?solid interface and the magnetic field is applied for several minutes. The dynamics of structure formation was studied by means of the registration and analysis of microscopic video images, through a Matlab image analysis script. Several parameters, such as the number of clusters, the perimeter-based fractal dimension and circularity, were calculated as a function of time. The time evolution of the number of clusters was found to follow a power-law behavior, with an exponent consistent with that found in other studies for magnetic systems, whereas the typical formation time depends on the particle diameter and field configuration. Complementarily, the magnetic properties of the formed structure were studied, reproducing the experiment with liquid paraffin as the containing fluid, and then letting it solidify. The sample obtained was studied by vibrating sample magnetometry. The magnetization curves show that the material obtained is a planar magnetically anisotropic material, which could eventually be used as an anisotropic magnetic sensor or actuator.","palabras_clave":"MATERIA|CONDENSADA|BLANDA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19256,"idioma_id":4,"titulo":"DESERTIFICATION RESEARCH IN ARGENTINA","resumen":"In Latin America, Argentina is second - behind Brazil - in extent of drylands: 55% of its territory. Research on desertification and dryland degradation has a lengthy tradition, being undertaken even prior to the establishment of the United Nations Convention to Combat Desertification. The paper aims to analyse desertification research in Argentina, the disciplines from which its knowledge arises and the topics receiving greater attention. The work focuses on the results from descriptive, bibliometric and social network analyses of a sample of articles on desertification in scientific journals indexed in Web of Science. A visual representation of citation relationships was created considering keywords such as ´desertification´, ´dry*land*´, ´*arid´ and ´development´, ´policy´ or ´economy´ among others, in ´Argentina´. According to this search, the number of papers per year dealing with desertification in Argentina is only 4·3. National knowledge, usually categorized as traditional knowledge, is barely captured by international databases. The challenge for the scientific community is to make traditional knowledge visible and disseminate the findings. Results demonstrate that desertification research in Argentina is in a great proportion related to studies of soil erosion and soil degradation, and only in a minor proportion to socioeconomic issues. However, desertification problems are the outcome of interactions among physical-biological, socioeconomic and political dimensions, and therefore, the science summoned to analyse them must not only be a science centred on isolated themes but also one resulting from interdisciplinary studies and integrated approaches.","palabras_clave":"desertification research|bibliometrics|social network analysis|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19257,"idioma_id":4,"titulo":"EGFR participates downstream of ER&#945; in estradiol-17&#946;-d-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets","resumen":"Estradiol-17&#946;-d-glucuronide (E17G) induces acute endocytic internalization of canalicular transporters, including multidrug resistance-associated protein 2 (Abcc2) in rat, generating cholestasis. Several proteins organized in at least two different signaling pathways are involved in E17G cholestasis: one pathway involves estrogen receptor alpha (ER&#945;), Ca2+-dependent protein kinase C and p38-mitogen activated protein kinase, and the other pathway involves GPR30, PKA, phosphoinositide 3-kinase\/AKT and extracellular signal-related kinase 1\/2. EGF receptor (EGFR) can potentially participate in both pathways since it interacts with GPR30 and ER&#945;. Hence, the aim of this study was to analyze the potential role of this receptor and its downstream effectors, members of the Src family kinases in E17G-induced cholestasis. In vitro, EGFR inhibition by Tyrphostin (Tyr), Cl-387785 or its knockdown with siRNA strongly prevented E17G-induced impairment of Abcc2 function and localization. Activation of EGFR was necessary but not sufficient to impair the canalicular transporter function, whereas the simultaneous activation of EGFR and GPR30 could impair Abcc2 transport. The protection of Tyr was not additive to that produced by the ER&#945; inhibitor ICI neither with that produced by Src kinase inhibitors, suggesting that EGFR shared the signaling pathway of ER&#945; and Src. Further analysis of ER&#945;, EGFR and Src activations induced by E17G, demonstrated that ER&#945; activation precedes that of EGFR and EGFR activation precedes that of Src. In conclusion, activation of EGFR is a key factor in the alteration of canalicular transporter function and localization induced by E17G and it occurs before that of Src and after that of ER&#945;.","palabras_clave":"EGFR|ER ALPHA|E17G|IRHC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19258,"idioma_id":4,"titulo":"Azospirillum brasilense increased salt tolerance of jojoba during in vitro rooting","resumen":"          Jojoba and Azospirillum  brasilense can survive at high NaCl concentrations but with some  undesirable effects. The aim of this work was to evaluate whether A. brasilense inoculation reduced the negative  effects of salinity on several clonal lines of the jojoba plant. Shoots were induced  in half-strength Murashige-Skoog medium with 24.6 mM or 49.2 µM indole-3-butyric acid for 6 days and grown  in an auxin-free medium with 0, 40, 80, 120 or 160 mM NaCl and inoculated  or not with 107 cfu of A. brasilense  Cd or Az39 for 45 days. Rooting percentage, shoot and root biometric parameters,  and root index were determined. Regressions of rooting percentage and root  index with respect to NaCl  concentration were performed for each combination of bacterization and indole-3-butyric  acid induction, and the 50% inhibitory concentration (IC50) was  determined. A. brasilense Cd and Az39 promoted rhizogenesis and  increased root index and IC50, reducing the undesirable effects of NaCl  on jojoba rooting. Both strains were successfully reisolated at the end of the  experiment. Here, we establish a useful model for evaluating plant-bacteria  interactions and selecting strains that promote plant growth under saline  conditions.  ","palabras_clave":"PLANT GROWTH-PROMOTING RHIZOBACTERIA|SALT STRESS|SIMMONDSIA CHINENSIS|ROOT INDEX|MICROPROPAGATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19259,"idioma_id":4,"titulo":"Energy management strategy based on receding horizon for a power hybrid system","resumen":"This paper presents an energy managementstrategy to operate a hybrid power system with renewable sources (wind andsolar), batteries, and polymeric electrolyte membrane fuel cells. The fuelcells are fed with hydrogen from bioethanol reforming. The energy managementstrategy uses the concept of receding horizon with predictions of the futuregeneration from the renewable sources, the future load, and the state of chargein the battery bank. Several tests are done in order to analyze the performanceof the proposed methodology. The results, compared with the case without predictions,show a reduction in the loss of power supply probability (LPSP) up to 88%.","palabras_clave":"RENEWABLE ENERGY SOURCES|BIOETHANOL|WIND ENERGY|SOLAR ENERGY|PEM FUEL CELLS|AUTOREGRESSIVE MODELS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19260,"idioma_id":5,"titulo":"Producción, Consumo y Espacialidad en Cueva Túnel, Meseta Central de Santa Cruz, Argentina","resumen":"En el presente artículo estudiamos la tecnología lítica del Componente Inferior del sitio Cueva Túnel, ubicado en la Meseta Central de Santa Cruz, Patagonia Argentina, datado en el Pleistoceno final. Centramos nuestro análisis en los procesos de producción y consumo de artefactos y en su articulación con la estructuración del espacio. Los resultados indican que la selección de las materias primas se vincula con una planificación de las tareas productivas en función a las actividades a realizar. El sitio habría funcionado principalmente como un sector de procesamiento primario de presas, dentro del marco de un circuito de movilidad regional.","palabras_clave":"PATAGONIA|LITICO|PRODUCCION-CONSUMO|PLEISTOCENO FINAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19261,"idioma_id":4,"titulo":"Contemporary topics and propositions in the study of procurement sources in ancient societies from Argentina","resumen":"During the last few years, there has been a notable increase inthe number of archaeological investigations focused on mineraloutcrops and sources in Argentina, taking into account differentchronological periods and the peculiarities of each geographical region in the country. Empirical references present novel characteristics, so there has been a growing sophistication of themethodological tools, and original techniques are being used fortheir identification. In this context, there has been an update inthe research questions and a greater emphasis on the developmentof theoretical concepts and perspectives.These tendencies and innovations aim to reconstruct the dynamics of the management of mineral resources in different social,chronological, and spatial scales. Technological and economictopics are being discussed. These include different strategies forthe procurement, transport, storage, conservation, transformation,use, and discard of the artifacts. Similarly, other social issues such asmobility, the circulation of raw materials and artifacts, and the useof the landscape are being addressed. Symbolic aspects related tothe life of the societies which used these resources are alsoanalyzed","palabras_clave":"propositions|procurement sources|ancient societies|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19262,"idioma_id":4,"titulo":"Characterization of the seascape used by juvenile and wintering adult Southern Giant Petrels from Patagonia Argentina","resumen":"The characterization of the seascape used by marine top predators provides a wide perspective of pelagic habitat use and it is necessary to understand the functioning of marine systems. The goal of this study was to characterize the oceanographic and biological features of marine areas used by adult and first year juvenile southern giant petrels (SGP, Macronectes giganteus) from northern Patagonian colonies (Isla Arce and Gran Robredo) during the austral fall and winter (2005, 2006, 2007, and 2008). The marine environment exploited by the SGP was characterized using sea surface temperature (SST), SST gradients, chlorophyll-a concentration, water depth, oceanographic regimes, and ocean surface winds. In addition, the biological seascape was defined by considering the distribution of squid during the months of study. Juveniles SGP exploited a wide range of environments focusing mainly on productive neritic waters using a variety of oceanographic regimes. Juveniles were exposed to eutrophic and enriched waters, probably because of the frequent presence of thermal fronts in their utilization areas. Adults' environments lacked of thermal fronts remaining the majority of their time within the oceanographic regime ?Continental Shelf?, in water depths of 100?200 m, exploiting mesotrophic and eutrophic environments, and remaining in areas of known food resources related to the presence of squid. For the most part, juveniles were exposed to westerly winds, which may have helped them in their initial flight to the shelf break, east of the colony. Wintering adults SGP also explored areas characterized by westerly winds but this did not play a primary role in the selection of their residence areas. Juveniles during their first year at sea have to search for food exploring a variety of unknown environments. During their search, they remained in productive environments associated to fronts and probably also associated to fisheries operating in their foraging areas. The understanding of pelagic birds' habitat selection and preferences through the year is crucial for the monitoring of anthropogenic impacts over these species. Further studies should focus on the prediction of variables that determine the distribution of these species though the year and during different life stages.","palabras_clave":"Southern Giant Petrel| Argentine Shelf|Oceanographic Characterization|First-year juveniles"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19263,"idioma_id":4,"titulo":"Lipase activity sensitive to dopamine, glucagon and cyclic AMP in the hepatopancreas of the euryhaline burrowing crab Neohelice granulata (Dana, 1851) (Decapoda, Grapsidae)","resumen":"We studied the biochemical characteristics and modulation by dopamine, glucagon and cAMPof lipase activity in hepatopancreas of the euryhaline crab Neohelice granulata (Dana, 1851),considered to be an emergent model for biochemical, physiological and ecological research.Lipase activity was maximum at pH 8.5; it exhibited Michaelis-Menten kinetics (apparent K=0.018 mM), was highest at 37°C but appeared to be cold- and heat-tolerant, since it was high at4°C and at 45°C. Lipase activity was enhanced upon incubation of hepatopancreas with 10Mdopamine (about 100%), 2 × 10&#8722;3M glucagon (about 250%) and 10&#8722;4m&#8722;4M cAMP (about 150%)suggesting a role of these chemical messengers in mechanisms of regulation of lipolytic activitiesand its direct effect on the hepatopancreas. The concomitant decrease in triglycerides content upondopamine and cAMP treatment suggests a link between enhanced lipase activity by these messengersand triglycerides catabolism.","palabras_clave":"LIPASE|DOPAMINE|GLUCAGON |CYCLIC AMP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19264,"idioma_id":4,"titulo":"Biochemical characteristics and modulation by external and internal factors of aminopeptidase-N activity in the hepatopancreas of a euryhaline burrowing crab","resumen":"Abstract Strikingly, in spite of its physiological importance,information about occurrence, biochemical characteristicsand mechanisms of regulationof aminopeptidaseN(APN)inthehepatopancreasofintertidaleuryhalinecrabsisstilllacking.Inthiswork,we determinedtheoccurrence,biochemical characteristics, response to environmentalsalinity and dopamine of APNin the hepatopancreas oftheeuryhalinecrabNeohelicegranulata(Dana1851)fromtheopen mudflat of Mar Chiquita coastal lagoon (BuenosAiresprovince,Argentina).APNactivitywasmaximal atpHand temperature range of 7.6?9.0 and 37?45°C,respectively.APNactivityexhibitedMichaelis?Menten kinetics(apparent Km=0.19±0.10mM)(pH 7.6, 37°C)andappeared to be sensitiveto bestatin (I&nbsp;= 15 mM)and EDTA (I5050&nbsp;= 9 mM). In crabs acclimated to 10 psu(hyper-regulation conditions) and 37 psu (hypo-regulationconditions), APNactivitywasabout 45 and 160%higher,respectively,thanin35psu(osmoconformation).APNactivityin the hepatopancreas wasstimulated in vitro(about137%)by 10&#8722;4&nbsp;M dopamine. Higher dopamineconcentrations produced a similar extent of increase. Theresponses of APN activity to salinity and dopamine in vitrosuggest the role of APN in digestive adjustments uponhyper and hypo-regulatory conditions and its modulationvia direct mechanisms on hepatopancreas by dopamine.","palabras_clave":"AMINOPEPTIDASE N|HEPATOPANCREAS|ENVIRONMENT|DOPAMINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19265,"idioma_id":4,"titulo":"Study of Galectins in Tumor Immunity: Strategies and Methods","resumen":"During the past decade, a better understanding of the cellular and molecular mechanisms underlying tumor immunity has provided the appropriate framework for the development of therapeutic strategies for cancer immunotherapy. Under this complex scenario, galectins have emerged as promising molecular targets for cancer therapy responsible of creating immunosuppressive microenvironments at sites of tumor growth and metastasis. Galectins, expressed in tumor, stromal, and endothelial cells, contribute to thwart the development of immune responses by favoring the expansion of T regulatory cells and contributing to their immunosuppressive activity, driving the differentiation of tolerogenic dendritic cells, limiting T cell viability, and maintaining T cell anergy. The emerging data promise a future scenario in which the selective blockade of individual members of the galectin family, either alone or in combination with other therapeutic regimens, will contribute to halt tumor progression by counteracting tumor-immune escape. Here we describe a selection of methods used to investigate the role of galectin-1 in tumor-immune escape.","palabras_clave":"galectins|tumors"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19266,"idioma_id":4,"titulo":"Regulation of Galectins by Hypoxia and Their Relevance in Angiogenesis: Strategies and Methods","resumen":"Formation of an aberrant and heterogeneous vascular network is a key pathological event in the multistep process of tumor growth and metastasis. Pro-angiogenic factors are synthesized and released from tumor, stromal, endothelial, and myeloid cells in response to hypoxic and immunosuppressive microenvironments which are commonly found during cancer progression. Emerging data indicate key roles for galectins, particularly galectin-1, -3, -8, and -9 in the regulation of angiogenesis in different pathophysiologic settings. Each galectin interacts with a preferred set of glycosylated receptors, triggers different signaling pathway, and promotes sprouting angiogenesis through different mechanisms. Understanding the role of galectins in tumor neovascularization will contribute to the design of novel anti-angiogenic therapies aimed at complementing current clinical approaches. Here we describe selected strategies and methods used to study the galectin-1 regulation by hypoxia and its role in blood vessel formation.","palabras_clave":"Galectin|Hypoxia|Angiogenesis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19267,"idioma_id":4,"titulo":"Antagonistic and synergistic responses to solar ultraviolet radiation and increased temperature of phytoplankton from cenotes (sink holes) of the Yucatán Peninsula, México","resumen":"Cenotes (sink holes) are karstic formations characteristic of the Yucatán Peninsula and are the main source of fresh water in the region. Because of their tropical location, they receive high levels of solar radiation and are exposed to high temperatures. However, the effect of these global-change-related variables on phytoplankton in cenotes is unknown. We carried out experiments with phytoplankton communities collected from 2 cenotes differing in their penetration of solar radiation (Leona Vicario [LV]: turbid, Las Mojarras [LM]: clear) to assess the combined effect of solar ultraviolet radiation (UVR; 280?400 nm) and increased temperature on their photosystem (PS) II photochemistry. We exposed samples in microcosms to solar radiation (with and without UVR) and 2 temperatures (ambient = 25°C and increased by 3°C) and analyzed photochemical performance over daily cycles. A significant antagonistic interaction between UVR and temperature in LV caused a combined inhibition of the effective photochemical quantum yield (&#934;PSII) that was smaller (63%) than the sum of the 2 individual effects of UVR and temperature (116%). In contrast, a significant synergistic interaction between UVR and temperature in LM caused the combined inhibition of &#934;PSII (172%) to be higher than the sum of the individual effects of the 2 variables (134%). Differences in the size distribution and taxonomic composition of the phytoplankton communities, with smaller cells in LV than in LM, seem to account for much of the variability in responses to UVR and increased temperature between the 2 communities. Our results suggest that phytoplankton communities from clear cenotes will be more affected by the combined effects of solar UVR and increased temperature that those from turbid cenotes.","palabras_clave":"CENOTES|PHYTOPLANKTON"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19268,"idioma_id":4,"titulo":"Physio-ecological responses of Patagonian coastal marine phytoplankton in a scenario of global change: Role of acidification, nutrients and solar UVR","resumen":"The aim of our study was to experimentally determine the future combined effects of solar UVR (280?400 nm), nutrient enrichment and acidification on a natural phytoplankton community (late phase of the bloom) of the Chubut River estuary (Patagonia, Argentina). We exposed the community to two radiation conditions(i.e., with and without UVR) under a future scenario of global change as compared to present conditions, using a cluster environmental approach. We combined short- (hours) and mid-term (days) incubations under solar radiation of the two clusters (present vs. future) to focus on changes in phytoplankton photosynthesis, growth and biodiversity. Our results indicate that the future conditions of increased nutrient availability and acidification, together with solar radiation, would shape the coastal phytoplankton community of Patagonia. The observed change for future conditions was towards a community dominated by relatively large diatoms, with high growth rates, little or no UVR-inhibition of photosynthesis, and better light-utilization efficiency. Given the speciesspecificity in responses, our results should not be generalized, especially considering that open waters of Patagonia are characterized by recurrent blooms of coccolithophorids that could be severely affected by acidification process. This future global change scenario in coastal waters, however, will produce significant increases in primary production, with phytoplankton communities that may sequester significant carbon amounts and thus they might sustain important secondary production (including fisheries) if their nutritional quality is not compromised.","palabras_clave":"CO2|PHYTOPLANKTON"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19269,"idioma_id":4,"titulo":"Fibulin-2 is a key mediator of the pro-neurogenic effect of TGF-beta1 on adult neural stem cells","resumen":"Transforming growth factor beta 1 (TGF-beta1), an anti-inflammatory   cytokine, has been shown to have pro-neurogenic effects on adult Neural   Stem Cells (aNSC) from the dentate gyrus and in vivo models. Here, we   expanded the observation of the pro-neurogenic effect of TGF-beta1 on   aNSC from the subventricular zone (SVZ) of adult rats and performed a   functional genomic analysis to identify candidate genes to mediate its   effect. 10 candidate genes were identified by microarray analysis and   further validated by qRT-PCR. Of these, Fibulin-2 was increased 477-fold   and its inhibition by siRNA blocks TGF-beta1 pro-neurogenic effect.   Curiously, Fibulin-2 was not expressed by aNSC but by a GFAP-positive   population in the culture, suggesting an indirect mechanism of action.   TGF-beta1 also induced Fibulin-2 in the SVZ in vivo. Interestingly, 5   out of the 10 candidate genes identified are known to interact with   integrins, paving the way for exploring their functional role in adult   neurogenesis. In conclusion, we have identified 10 genes with putative   pro-neurogenic effects, 5 of them related to integrins and provided   proof that Fibulin-2 is a major mediator of the pro-neurogenic effects   of TGF-beta1. These data should contribute to further exploring the   molecular mechanism of adult neurogenesis of the genes identified and   the involvement of the integrin pathway on adult neurogenesis.","palabras_clave":"ADULT NEURAL STEM CELLS|ADULT NEUROGENESIS|FIBULIN-2|GENOMICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19270,"idioma_id":4,"titulo":"Exfoliative cytology as a tool for monitoring pre-malignantand malignant lesions based on combined stains andmorphometry techniques","resumen":"Background: prevention and early diagnosis have the greatest potential for public health  and are the most effective method in the long-term to control oral cancer. The aim was to  apply PAP staining together with AgNOR staining and morphometric analysis in oral  exfoliative cytology, in order to determine the sensitivity and specificity of these methods  in the detection of malignant changes for the purposes of both initial population monitoring  and follow-up.  Methods: AgNOR, Papanicolau, and morphometric tests were conducted in samples of  patients with oral cancer, oral potentially malignant disorders and controls (opposite side of  lesions). Specificity and sensitivity values for each stain method and the curve under ROC  area were estimated.  Results: The diagnostic variables which allowed greatest accuracy in identifying  malignancy relative to the healthy control were cluster (76.92%), satellite (75.64%) and  total (90%). The diagnosis was seen to be associated with PAP and total AgNOR, total  AgNOR and PAP, total AgNOR and satellites and clusters, and total AgNOR nuclear area  \/cytoplasmic area ratio.  Conclusions: the total number of AgNOR is a reliable marker for detecting neoplastic  cells; this method increases sensitivity and specificity by decreasing the likelihood of false  negatives or positives, as the accuracy obtained was 90%. It is also a low-cost, noninvasive,  simple methodology that can be recommended to help the early detection of oral  cancer and monitoring of patients with a first diagnosis of cancer","palabras_clave":"CYTOLOGY|PAP|AgNOR|ORAL CANCER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19271,"idioma_id":4,"titulo":"Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina","resumen":"Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina","palabras_clave":"SWINE|TUBERCULOSIS|INFECTION|ARGETNINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19272,"idioma_id":4,"titulo":"From a lag in vector activity to a constant increase of translocations: invasion of Callosciurus squirrels in Argentina","resumen":"Arboreal squirrels of the Asiatic genus Callosciurus have shown high likelihood of establishmentfrom few released animals, in particular, C. erythraeus has established wild populations in Argentina,Belgium, France, Hong Kong, Japan, and The Netherlands. We report the invasion process of C.erythraeus in Argentina in the last four decades and suggest management actions for each foci. BetweenFebruary 2011 and November 2014 we conducted field surveys and interviews in nine sites in centralArgentina to confirm the presence of C. erythraeus, describe their history of introduction, and estimaterange expansion and squirrel relative abundance. We report a two decades lag-phase until the onset oftranslocations of C. erythraeus within national boundaries that resulted in a constant increase of thecumulative number of releases. We confirm nine new release events between 1995 and 2012 and six new invasion foci that yields a total of 13 deliberate releases and 10 invasion foci established in rural andurban areas of Argentina. Spread rate ranged from 0.12 to 0.66 km\/year. An intermediate relative density of squirrels (2?7 ind\/ha) was found close to release sites except in one case. All introduction events involved squirrels translocated from the first, 40 yearsold invasion focus, occasionally involving illegal trade. The rate of introduction events in the lastdecades and the translocation-lag phase described in this study should call the attention in all countriesdealing with charismatic, introduced species. Translocationdisruption requires urgent attention to slowdown the invasion of this and other species","palabras_clave":"animal translocation|introduced squirrels|callosciurus erythreus|lag phase"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19273,"idioma_id":4,"titulo":"Acceleration of Reggianito cheese ripening. Effect of increased initial ripening temperatures on biochemical and sensory characteristics","resumen":"The acceleration of cheese ripening is of major interest in the cheese industry because it is related to both product characteristics and production costs. In this study, different temperature-time combinations using elevated temperatures of 20°C within the first month of maturation were applied during Reggianito cheese ripening. Data obtained from proteolysis, lipolysis, analysis of volatile compounds and sensory analysis were considered to establish optimal ripening conditions. Principal component analysis showed that the two first principal components explained 56.4% of data variability. Ripening at 20°C during the first month followed by 12°C resulted in 4-month-old cheeses with characteristics similar to Reggianito cheese traditionally ripened for 6 months at 12°C.","palabras_clave":"REGGIANITO CHEESE|RIPENING|ACELERATION|ELEVATED TEMPERATURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19274,"idioma_id":4,"titulo":"Seasonal changes and endocrine regulation of pejerrey (Odontesthes bonariensis) spermatogenesis in the wild","resumen":"The endocrine mechanisms that regulate spermatogenesis and their interacti on with environmental cues have been poorly studied compared w ith oogenesis in &#64257;sh. The aim of this work was to study the sper-matogenesis in pejerrey under the in&#64258;uence of photoperiod and water temperature &#64258;uctuation in the wild, evaluating the transcript leve ls of brain Gnrh variants and cyp19a1b , pituitary Gth subunits, gonadal&nbsp; the receptors, 11b -hsd , and 11-KT plasma levels. Males at spermiogenic stage were observed during spring and autumn, under a photoperiod above 11 h of light and a water temperature below 23 C. Most arrested males were observed in summer when w ater temperatures increased above 23  C. Males at sper-matogon ial stage w ere mainly observed in autumn, while most males at spermatocytary stage were caught in winter. An increase of gnrh-I , cyp19a1b , fshb , gpha and 11 b-hsd transcripts and 11-KT plasma levels was observed during spermatogonial and\/or spermatocytary stage (early spermatogenesis). The spermiogenic stag e was associated to the maximum gnrh-I gene expression level and a signi&#64257;cant increase of Gth receptors transcripts, being this fact more evident for lhcgr . During this last gonadal stage, cyp19a1b transcript level remained high, while fshb mRNA and 11-KT plasma levels showed a signi&#64257;cant decreased compared to that occurred at the sperma tocytary stage. Also, gpha and 11b -hsd gene expres-sion levels fell during spermiation up to similar values to those observed in arrested males. A signi&#64257;cant correlation between 11-KT and gnrh-I , cyp19a1b , gph a, fshb , 11 b-hsd transcripts, and the number of sperma tocytes was observed during spermatogenesis. All these &#64257;ndings suggested that in pejerrey, the sperma tocyte proliferation occurs mainly during winter under the stimulation of 11-KT induced by FSH through the stimulation of speci&#64257;c enzymes, including the 11b -hsd while spermiation occurs after photoperiod increase and with temperatures of the water below 23 C, through the stimulation of gnrh-I , cyp19a1b and lhcgr.","palabras_clave":"Brain?pituitary?gonad axis  |Environmental cues |Reproductive hormones|Pejerrey Spermatogenesis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19275,"idioma_id":4,"titulo":"Jaw myology and bite force of the monk parakeet (Aves, Psittaciformes)","resumen":"Psittaciform birds exhibit novelties in jaw bone structure and musculature that are associated with strong bite forces. These features include an ossified arcus suborbitalis and the muscles ethmomandibularis and pseudomasseter. We analyse the jaw musculature of the monk parakeet (Myiopsitta monachus) to enable future studies aimed at understanding craniofacial development, morphology, function and evolution. We estimate bite force based on muscle dissections, physiological cross-sectional area and skull biomechanical modelling. We also compare our results with available data for other birds and traced the evolutionary origin of the three novel diagnostic traits. Our results indicate that, in Myiopsitta, (i) the arcus suborbitalis is absent and the orbit is ventrally closed by an elongate processus orbitalis and a short ligamentum suborbitale; (ii) the ethmomandibularis muscle is a conspicuous muscle with two bellies, with its origin on the anterior portion of the septum interorbitale and insertion on the medial aspect of the mandible; (iii) the pseudomasseter muscle consists of some fibers arising from the m. adductor mandibulae externus superficialis, covering the lateral surface of the arcus jugalis and attaches by an aponeurotic sheet on the processus orbitalis; (iv) a well-developed adductor mandibulae complex is present; (v) the bite force estimation relative to body mass is higher than that calculated for other non-psittaciform species; and (vi) character evolution analysis revealed that the absence of the arcus suborbitalis and the presence of the m. pseudomassseter are the ancestral conditions, and mapping is inconclusive about presence of one or two bellies of the m. ethmomandibularis.","palabras_clave":"MYIOPSITTA MONACHUS|ethmomandibularis muscle|evolutionary novelties|neotropical parrots|physiological cross-sectional area|pseudomasseter muscle |skull biomechanics|SUBORBITAL ARCH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19276,"idioma_id":4,"titulo":"Comparative brain morphology of Neotropical parrots (Aves, Psittaciformes) inferred from virtual 3D endocasts","resumen":"Psittaciformes are a very diverse group of non-passerine birds, with advanced cognitive abilities and highlydeveloped locomotor and feeding behaviours. Using computed tomography and three-dimensional (3D)visualization software, the endocasts of 14 extant Neotropical parrots were reconstructed, with the aim ofanalysing, comparing and exploring the morphology of the brain within the clade. A 3D geomorphometricanalysis was performed, and the encephalization quotient (EQ) was calculated. Brain morphology characterstates were traced onto a Psittaciformes tree in order to facilitate interpretation of morphological traits in aphylogenetic context. Our results indicate that: (i) there are two conspicuously distinct brain morphologies, oneconsidered walnut type (quadrangular and wider than long) and the other rounded (narrower and rostrallytapered); (ii) Psittaciformes possess a noticeable notch between hemisphaeria that divides the bulbusolfactorius; (iii) the plesiomorphic and most frequently observed characteristics of Neotropical parrots are arostrally tapered telencephalon in dorsal view, distinctly enlarged dorsal expansion of the eminentia sagittalisand conspicuous fissura mediana; (iv) there is a positive correlation between body mass and brain volume; (v)psittacids are characterized by high EQ values that suggest high brain volumes in relation to their body masses;and (vi) the endocranial morphology of the Psittaciformes as a whole is distinctive relative to other birds. Thisnew knowledge of brain morphology offers much potential for further insight in paleoneurological,phylogenetic and evolutionary studies.","palabras_clave":"3-D BRAIN RECONSTRUCTIONS|AVES|ENDOCRANIAL MORPHOLOGY|GEOMETRIC MORPHOMETRICS|CHARACTERS MAPPING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19277,"idioma_id":4,"titulo":"The infrared and molecular environment surrounding the Wolf-Rayet star WR 130","resumen":"&nbsp;We present a multi-wavelength study of the environment of the Wolf-Rayet star WR130 to investigate the molecular and dustdistributions in the context of the neutral hydrogen and radio continuum structures already analyzed by Cichowolski et al. (2001). We also investigate the presence of young stellar object candidates possibly triggered by the action of WR130 onto the molecular gas.&nbsp;We use CO data obtained from the FCRAO survey to analyze the distribution and properties of the molecular gas, andinfrared data from the WISE and Herschel surveys to obtain the dust properties. Candidate young stellar objects are identified fromcataloged point sources (IRAS, MSX and WISE) and compared with the molecular distribution. We then discuss their physicalparameters using their spectral energy distributions.&nbsp;The molecular data show a ring-like structure in the same velocity interval where an Hi shell was detected by Cichowolskiet al. (2001).We have identified and characterized four main molecular clouds. The infrared emission also presents, at all wavelengths,a well defined shell structure.We have identified eight young stellar object candidates distributed mostly in the regions of high columndensity. Among these sources we identified two groups located onto molecular clouds presenting a bright rim, suggesting that theradiative driven implosion (RDI) mechanism may be acting in these clouds. Bearing in mind that WR130 is an evolved star we arguethat the star formation at the edges of the ionized region created by this star might have been triggered.","palabras_clave":"Stars: individual: WR130|ISM: bubbles|Hii regions|Stars: formation|Infrared: ISM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19278,"idioma_id":5,"titulo":"Mineralizacion de sulfuros en las ofiolitas famatinianas y rocas asociadas, Calingasta, Precordillera de San Juan","resumen":"En la Precordillera occidental de la provincia de San Juan se encuentran basaltos pertenecientes a  una ofiolita de edad famatiniana. Son interpretados como formados en un ambiente extensional en una cuenca oceánica poco profunda cercana a bordes continentales cubiertos por sedimentos pelágicos y turbidíticos. Se presentan como cuerpos macizos o mantos concordantes a subconcordantes y según la composición química son basaltos tholeiíticos de tipo MORB.En la región de Calingasta, las mineralizaciones corresponden a dos tipos de depósitos: a) la mina Santa Elena, un sulfuro masivo máfico pelítico, rico en metales preciosos, pobre en Cu y con elevados tenores de Pb y Zn, cuya paragénesis primaria, masiva y diseminada, consta de pirita, calcopirita, galena, esfalerita, tetraedrita argentífera, bournonita, marcasita, melnikovita, arsenopirita, oro y molibdenita. En la potente zona de oxidación se halla una veintena de sulfatos de hierro. b) una mineralización de sulfatos de Al y Mg, asociada a los sedimentos de la Formación Alcaparrosa, en alternancia con los basaltos, fundamentalmente en lutitas,  producto de la oxidación de la pirita diseminada en ellas y la reacción con sus minerales aluminosilicáticos.La región de Calingasta se considera un área de interés prospectivo por su potencial para alojar otros cuerpos de sulfuros masivos.","palabras_clave":"sulfuros masivos|sulfatos|Santa Elena|ofiolita"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19279,"idioma_id":4,"titulo":"'Starch consolidation casting of cordierite precursor mixtures - Rheological behavior and green body properties'","resumen":"The rheology of suspensions and mechanical properties of green bodies with cordierite composition (raw materials 37 wt% kaolin, 41 wt% talc, 22 wt% alumina, resulting in 46.6 wt% SiO2, 38.1 wt% Al2O3, 13.6 wt% MgO) and two types of starch (corn or potato) are investigated. Rotational viscometry of suspensions with solids loading 50, 60, and 70 wt% without starch showed that all tend to be shear-thinning with a small degree of thixotropy. Suspensions with a total solids loading of 60 wt% with 25 wt% replaced by starch exhibited higher viscosity and thixotropy, but the viscometric behavior is almost identical for the two starch types (apparent viscosities 130-50 mPa·s). Oscillatory rheometry shows that for suspensions with potato starch the onset temperature for gelatinization is 61C-63C, that is, lower than for corn starch (72C-73C). Maximum storage moduli and phase shift values after gelatinization are similar for both systems. The mechanical properties of green disks, measured via diametral compression tests, reveal clear differences between materials prepared with corn and potato starch, with the latter showing higher elastic modulus, higher strength, and higher deformation at fracture, obviously because of incompletely gelatinized starch granules in the green bodies prepared with corn starch.","palabras_clave":"XX"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19280,"idioma_id":4,"titulo":"A new megaflora (fossil woods and leaves) from the Miocene of southwestern Patagonia","resumen":"A new megaflora composed of fossil woods and leaves is described. Bearing sediments overlay the Santa Cruz Formation (early Miocene), making it one of the youngest fossil megafloras described from southern Patagonia. Fossil woods are carbonized and found as clasts of a conglomerate. They comprise few specimens representing Araucariaceae (Agathoxylon sp.), Podocarpaceae (Phyllocladoxylon sp.), Cupressaceae (Cupressinoxylon sp.) and two indeterminable angiosperms with anatomy consistent with Nothofagaceae. Most leaves are assigned to Nothofagaceae while fewer specimens are related to Lauraceae, Typhaceae, Leguminosae, and a conifer. The recovered assemblage suggests a temperate climate similar to that of northern Patagonia today, where living relatives of the fossils described herein inhabit.","palabras_clave":"FOSSIL WOOD|FOSSIL LEAVES|ARROYO DE LOS CIERVOS|MIOCENE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19282,"idioma_id":4,"titulo":"Public health approach to birth defects: the Argentine experience","resumen":"Birth defects are a global problem, but their impact is particularly severe in low and middle income countries, where the conditions for prevention, treatment, and rehabilitation are more critical. The epidemiological transition in the infant mortality causes, and the concern of the community and the mass media about the teratogenic risk of environmental pollutants, has made health authorities aware of the importance of birth defects in Argentina. The objective of this paper is to outline those actions specifically taken in Argentina aimed at the prevention of birth defects at a national level. Firstly, we focus on birth defects in Argentina on a general basis, and then we present different laws and actions taken in terms of surveillance and public health programs, primary, secondary, and tertiary prevention. Finally, we present the Teratology Information Service 'Fetal Health Line', and the genetic services organization and health professionals training by the National Center of Medical Genetics and the National Program of Genetics Network. In conclusion, in the country, several programs focus on different approaches to the problem, and the challenge is to coordinate the teamwork between them. Finally, we list tips to address birth defects from the public health perspective.","palabras_clave":"Agentina|Epidemiology|Birth Defects"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19283,"idioma_id":4,"titulo":"Personalized virotherapy in cancer","resumen":"Personalized virotherapy in cancerEduardo G Cafferata andOsvaldo L PodhajcerLaboratory of Molecular andCellular Therapy, Fundacion Instituto Leloir, IIBBA-CONICET, Argentina.After decades of intensive research, pancreaticadenocarcinoma (PDAC) remains a highly lethal disease with a median survivaltime that does not exceed 6.5 months (1). Since morethan 80% of patients present with advanced metastatic disease, systemicchemotherapy remains the only treatment. The high resistance to conventionaland targeted therapies in PDAC as in other desmoplastic tumors of adults islargely due to the dense extracellular matrix (ECM). The ECM distorts blood andlymphatic vessels structure that hampers the possibility of systemicallydelivered therapies to reach the tumor mass (2). The use of engineered oncolytic viruses (OVs) isa promising new therapy for cancer treatment. Different OVs have beenengineered to express immune stimulatory molecules indicating that OVs can act attwo levels, by directly killing malignant cells in concurrence with the simultaneousactivation of the host anti-tumor immunity. OVs can be also combined withchemotherapeutic agents providing an aggressive platform for cancer attack. Oneof these OVs, a Herpes Simplex virus named T-VEC armed with GM-CSF has justcompleted a phase III trial in advanced melanoma with promising results andmight reach the clinic after FDA approval (Clinical Trials.gov Identifier NCT01740297).Conditionally Replicative Adenoviruses areoncolytic adenoviruses (OAV) engineered to selectively replicate within andkill tumor cells. Selectivity is obtained through the use of ??cancer cell??- specificpromoters (CCSP) that are selected to replace viral promoters and drive theexpression of genes essential for OAV replication. OAVs replicate essentially inmalignant cells with positive expression of the gene from which the CCSP wasselected. OAVs efficacy can be also improved through the exchange of the capsidfiber of the virus or addition of specific moieties that will retarget vectorsto enter the cell through alternative receptors (3). &nbsp;As for other therapeutic modalities, viral spreadand therapeutic efficacy is hampered by the ECM barrier. With this in mind, we startedengineering OAVs whose replication was driven by CCSPs active both in thestroma and in the malignant compartment of the tumor mass. The OAV AdF512 retargetedto bind to an alternative cell surface receptor and carrying DNA elementsresponsive to hypoxia and inflammation exhibited enhanced efficacy on melanomaxenografts made of human melanoma cells mixed with human fibroblasts (4). AdF512v1was also able to lyse fresh samples obtained from ovary cancer patients includingsamples refractory to chemotherapy (5). Morerecently we have shown that the OAV AV25CDC combined with gemcitabine exhibiteda large efficacy and complete absence of toxicity in preclinical models ofpancreatic cancer in mice and syriam hamsters (6). AV25CDC wasable to disrupt tumor architecture by inducing an increase in MMP-9 activity thatwould have facilitated gemcitabine penetration deeply inside the tumor mass (6). Recentstudies have shown that cancer-associated fibroblasts can render malignantcells more permissive to OVs infection through a cross-talk signaling thatinvolves stromal and tumor derived factors (7). Inaddition to the efforts to improve viral dissemination and the secondary immuneresponse, it is tempting to anticipate, as with current targeted therapies thatnot all patients will benefit from this oncolytic immune-virotherapy. Thus, thequestion arises whether there is any possibility to predict patient response tothis treatment. The use of patient derived xenografts (PDXs) is gainingmomentum as a tool to predict response (8).&nbsp; &nbsp;In PDXsmodeling, samples obtained from patient´s tumors or circulating tumor cells areimplanted in immunocompromised mice either ectopically or orthotopically.&nbsp; Once tumors grow in mice different treatmentcombinations can be implemented to establish the most efficacious one. From availabledata with other therapeutic modalities it appears that PDX models are the bestpreclinical model to test different combinations of OAVs with drugs of currentuse in pancreatic cancer. In addition, genomic firms can be obtained frominterrogating resistant vs sensitive PDX tumors. An important caveat in PDAC isthat nearly half of original tumors grow in mice, generallywithin two to six months which in some cases is coincidental with patientsurvival. We propose that in order to advance thefield of targeted virotherapy it will be important to establish a procedure involvingan initial step consisting in the assessment in the patient´s tumor biopsy ofthe expression levels of the viral receptor and the gene corresponding to theCCSP; these data should be complemented with the in vitro lytic effect of theOAV on the tumor explant; in parallel, the therapeutic efficacy of the OAVcombined with other treatments should be assessed in the PDXs. The integrationof the whole data might help predict virus efficacy combined with othermodalities to guide patients? treatment. These approaches combined with thedevelopment of a genomic firm associated with sensitivity vs resistance to virusactivity in the PDXs (and in patients) might help in selecting patients inadvance that will benefit from OAV therapeutics.","palabras_clave":"ONCOLYTIC ADENOVIRUS|VIROTHERAPY|PANCREATIC CANCER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19284,"idioma_id":4,"titulo":"Lidar Observations of cirrus clouds in Buenos Aires","resumen":"Characterization of cirrus clouds over Buenos Aires (34.6°S, 58.5°W)  using a ground based lidar is presented. The study, carried out for the period  2010?2011, reveals that cirrus are usually found in the altitude region  8?11&nbsp;km, with mid-cloud temperatures values varying between &#8722;75&nbsp;°C  and 55&nbsp;°C. The clouds, whose bases altitudes display significant  variability while their tops remains close to the tropopause, show geometrical  thickness ranging from 1.2 to 5&nbsp;km, with on average value 3.0±0.9&nbsp;km.  Most commonly observed cirri can be characterized as optically thin cirrus  rather than dense ones, with a mean optical depth value of 0.26±0.11 and an  applied multiple scattering factor ç of 0.85±0.07. In this  region, the optical depth increases with increasing geometrical thickness with  a partially linear correlation. Lidar ratios are also analyzed and on average  the value is 32±17&nbsp;sr.","palabras_clave":"LIDAR MEASUREMENTS|CIRRUS CLOUDS|OPTICAL DEPTH|LIDAR RATIO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19285,"idioma_id":4,"titulo":"Emerging roles of exosomes in normal and pathological conditions. New insights for diagnosis and therapeutic applications.","resumen":"From the time when they were first described in the 1970s by the group of Johnstone and Stahl, exosomes are a target of constant research. Exosomes belong to the family of nano-vesicles which are of great interest for their many functions and potential for diagnosis and therapy in multiples diseases. Exosomes originate from the intraluminal vesicles of late endosomal compartments named multivesicular bodies and the fusion of these late endosomes with the cell membrane result in the release of the vesicles into the extracellular compartment. Moreover, their generation can be induced by many factors including extracellular stimuli, such as microbial attack and other stress conditions.   The primary role attributed to exosomes was the removal of unnecessary proteins from the cells. Now, several studies have demonstrated that exosomes are involved in cell-cell communication, even though their biological function is not completely clear.  The participation of exosomes in cancer is the field of microvesicle research that has expanded more over the last years. Evidence proving that exosomes derived from tumor-pulsed dendritic cells, neoplastic cells and malignant effusions, are able to present antigens to T cells, has led to numerous studies using them as cell free cancer vaccines.  Since exosomes derive from all cell types, they contain proteins, lipids and miRNA capable of regulating a variety of target genes. Much research is being conducted, which focuses on the employment of these vesicles as biomarkers in the diagnosis of cancer in addition to innovative biomarkers for diagnosis, prognosis and management of cardiovascular diseases. Interesting findings indicating the role of exosomes in the pathogenesis of several diseases have encouraged researchers to consider their therapeutic potential not only in oncology but also in the treatment of autoimmune syndromes and neurodegenerative disorders such as Alzheimer´s and Parkinson´s disease; in addition to infectious disease.","palabras_clave":"EXOSOMES|CLINICAL APPLICATION|MICROVESICLES|PATHOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19286,"idioma_id":4,"titulo":"Clade 8 and Clade 6 Strains of Escherichia coli O157:H7 from Cattle in Argentina have Hypervirulent-Like Phenotypes","resumen":"The hemolytic uremic syndrome (HUS) whose main causative agent is enterohemorrhagicEscherichia coli (EHEC) O157:H7 is a disease that mainly affects children under 5 years ofage. Argentina is the country with the highest incidence of HUS in the world. Cattle are amajor reservoir and source of infection with E. coli O157:H7. To date, the epidemiologicalfactors that contribute to its prevalence are poorly understood. Single nucleotide polymorphism(SNP) typing has helped to define nine E. coli O157:H7 clades and the clade 8 strainswere associated with most of the cases of severe disease. In this study, eight randomly selectedisolates of EHEC O157:H7 from cattle in Argentina were studied as well as twohuman isolates. Four of them were classified as clade 8 through the screening for 23 SNPs;the two human isolates grouped in this clade as well, while two strains were closely relatedto strains representing clade 6. To assess the pathogenicity of these strains, we assayedcorrelates of virulence. Shiga toxin production was determined by an ELISA kit. Four strainswere high producers and one of these strains that belonged to a novel genotype showedhigh verocytotoxic activity in cultured cells. Also, these clade 8 and 6 strains showed highRBC lysis and adherence to epithelial cells. One of the clade 6 strains showed stronger inhibitionof normal water absorption than E. coli O157:H7 EDL933 in human colonic explants.In addition, two of the strains showing high levels of Stx2 production and RBC lysis activitywere associated with lethality and uremia in a mouse model. Consequently, circulation ofsuch strains in cattle may partially contribute to the high incidence of HUS in Argentina.","palabras_clave":"Escherichia coli O157:H7|Hypervirulent-Like|Cattle |Clade 8|Clade 6"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19287,"idioma_id":4,"titulo":"A RhoA Signaling Pathway Regulates Dendritic Golgi Outpost Formation","resumen":"The neuronal Golgi apparatus (GA) localizes to the perinuclear region and dendrites as tubulo-vesicular structures designated Golgi outposts (GOPs). Current evidence suggests that GOPs shape dendrite morphology and serve as platforms for the local delivery of synaptic receptors. However, the mechanisms underlying GOP formation remain a mystery. Using live-cell imaging and confocal microscopy in cultured hippocampal neurons, we now show that GOPs destined to major 'apical' dendrites are generated from the somatic GA by a sequence of events involving: (1) generation of a GA-derived tubule; (2) tubule elongation and deployment into the dendrite; (3) tubule fission; and (4) transport and condensation of the fissioned tubule. A RhoA-Rock signaling pathway involving LIMK1, PKD1, slingshot, cofilin, and dynamin regulates polarized GOP formation by controlling the tubule fission. Our observations identify a mechanism underlying polarized GOP biogenesis and provide new insights regarding involvement of RhoA in dendritic development and polarization.","palabras_clave":"GOLGI APPARATUS|GOLGI OUTPOSTS|RHOA|DENDRITE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19288,"idioma_id":5,"titulo":"Estudio de prevalencia y letalidad neonatal en pacientes con anomalías congénitas seleccionadas con datos del Registro Nacional de Anomalías Congénitas de Argentina","resumen":"Introducción. Las anomalías congénitas (AC), en Argentina, representan el 26% de las defunciones infantiles. La tasa de letalidad de AC mide el riesgo de morir entre los afectados. Objetivos. Describir la prevalencia al nacer de un grupo de AC seleccionadas, estimar la tasa de letalidad neonatal y analizar su asociación con diferentes variables. Población y métodos. El estudio se realizó con datos del Registro Nacional de Anomalías Congénitas. Se calcularon las prevalencias de encefalocele, espina bífida, gastrosquisis, onfalocele, hernia diafragmática, atresia de esófago, atresia intestinal o malformación anorrectal (período 2009-2013). La letalidad se evaluó a los 7 y a los 28 días de vida en los afectados de presentación aislada (año 2013). Se analizó la asociación con las variables sexo, edad gestacional, peso al nacer, detección ecográfica prenatal, porcentaje de necesidades básicas insatisfechas del departamento de residencia materna, región geográfica y nivel de complejidad del hospital de nacimiento. Resultados. Gastrosquisis fue la AC de mayor prevalencia (8,53\/10 000 nacimientos) y hernia diafragmática, la de mayor tasa de letalidad neonatal (66,67%). En el total de las AC seleccionadas, fue significativa la asociación entre mayor edad gestacional y sobrevida a los 7 días ?OR: 0,81 (0,70-0,95)? y a los 28 días de vida  ?OR: 0,79 (IC 95%: 0,68-0,91)?. Mayor porcentaje de necesidades básicas insatisfechas se asoció a mayor letalidad con hernia diafragmática ?OR: 1,59 (IC 95%: 1,30-1,95)? y con atresia intestinal o malformación anorrectal ?OR: 16,00 (IC 95%: 1,63-157,24)?. Conclusiones. La alta prevalencia de gastrosquisis coincide con el aumento a nivel mundial. La prematurez y el alto porcentaje de necesidades básicas insatisfechas incrementaron el riesgo de morir en los afectados. Palabras clave: mortalidad neonatal, anomalías congénitas, letalidad, mortalidad infantil, Argentina.","palabras_clave":"prevalencia y letalidad neonatal |anomalías congénitas | Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19289,"idioma_id":4,"titulo":"Soybean and wheat response to lime in no-till Argentinean mollisols","resumen":"Crop production in Argentina has significantly increased over the past few years; this increase was consequence of better management practices which included P and N fertilization and, occasionally, S fertilization. Commonly used rates, however, are not sufficient to balance nutrients export in grain crops. This situation is particularly negative for meso-nutrients (Ca+2 and Mg+2) because they are not normally applied by farmers. The objective of this study was to determine the effect of lime over four years period on soybean, one year period on wheat and on a one year double cropped wheat\/soybean combination on no-till. The experimental design was a randomized complete blocks design with three replications and two combinations of lime (with and without). Results showed that lime application significantly increased soil pH, exchangeable Ca+2 content, and therefore, base saturation and Ca+2 saturation in cation exchangeable capacity (CEC). As average growing seasons, the relative increments due to lime application were 8, 22, 18, and 20% for pH, soil exchangeable Ca+2 content, base saturation and Ca+2 saturation in CEC, respectively. Results showed that soil bulk density and penetration resistance were not affected by lime application. Soil structure stability was significantly affected by lime application. Wheat grain yield was not affected by lime, but soybean grain yield was significantly increased by lime (7% average across year). Cumulative grain yield was significantly increased by lime application indicating that the benefits of liming were cumulative over time (27,556 vs 28,629&nbsp;kg&nbsp;ha&#8722;1 for lime and no lime, respectively). Increments in relative grain yield were not associated with soil pH in both crops; however, significant relationships were determined between relative soybean grain yield and soil Ca+2 content, base saturation and Ca+2 content in CEC. A soil Ca+2 critical concentration of 12.4&nbsp;meq&nbsp;100&nbsp;g&#8722;1 was determined to obtain 95% of relative soybean grain yield. The study concluded that soil Ca+2 content would limit soybean grain yield as a consequence of cation unbalance in intensive agriculture soil.","palabras_clave":"ARGENTINA|BASE SATURATION|GRAIN YIELD|LIME SOIL PH|SOIL CA+2 CONTENT|SOYBEAN|WHEAT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19290,"idioma_id":4,"titulo":"Partial and total C-6 oxidation of gelling carrageenans. Modulation of the antiviral activity with the anionic character","resumen":"tThe optimal conditions for the full C-6 oxidation of - and -carrageenans using (2,2,6,6-tetramethylpiperidinyl)oxy (TEMPO) in the presence of sodium hypochlorite and sodium bromide wereassessed. The fully oxidized products were characterized by NMR spectroscopy. Partially oxidized prod-ucts were also obtained and analyzed by chemical and spectroscopical methods. The antiviral activity ofcarrageenans against herpes simplex virus HSV-1 and HSV-2 determined by plaque reduction assay, wasnot largely affected by full oxidation of the polysaccharides, but an increase in activity was detected bypartial oxidation. A specific overoxidation on C-2 of the 3,6-anhydrogalactose moiety of -carrageenanwas identified, solved experimentally and rationalized through the application of molecular modeling.","palabras_clave":"Carrageenan|Oxidation|Antiviral|Herpes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19291,"idioma_id":4,"titulo":"Characterization of functional  SSR  markers  in  Prosopis  alba  and  their  transferability  across  Prosopis  species","resumen":"Aim of study: The aim of the study was to characterize functional microsatellite markers in Prosopis alba and examine the transferability to species from the Prosopis genus.Area of the study: samples were obtained from natural populations of Argentina.Material and Methods: Eleven SSR functional markers related to stress and metabolism were amplified in a sample of 152 genotypes from P.alba, P. denudans, P. hassleriP. chilensis, P. flexuosa, and interspecific hybrids.Main results: In P. alba, the PIC average value was 0.36; and 6 out of the 11 primers showed high values of polymorphism ranging from 0.40 to 0.71. The cross-species transferability was high with high percentages of polymorphic loci.Research highlights: The SSR markers developed in P.alba were easily transferred to other Prosopis species which did not have functional markers.","palabras_clave":"Prosopis|Microsatellites|genetic variation|functional markers"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19292,"idioma_id":4,"titulo":"Eastern Andean environmental and climate synthesis for the last 2000 years BP from terrestrial pollen and charcoal records of Patagonia","resumen":"The Southern Hemisphere Westerly Winds (SWW) constitutes an important zonal circulation system that dominates the dynamics of Southern Hemisphere mid-latitude climate. Little is known about climatic changes in the Southern South America in comparison to the Northern Hemisphere due to the low density of proxy records, and adequate chronology and sampling resolution to address environmental changes of the last 2000 years. Since 2009, new pollen and charcoal records from bog and lakes in northern and southern Patagonia at the east side of the Andes have been published with an adequate calibration of pollen assemblages related to modern vegetation and ecological behaviour. In this work we improve the chronological control of some eastern Andean previously published sequences and integrate pollen and charcoal dataset available east of the Andes to interpret possible environmental and SWW variability at centennial time scales. Through the analysis of modern and past hydric balance dynamics we compare these scenarios with other western Andean SWW sensitive proxy records for the last 2000 years. Due to the distinct precipitation regimes that exist between Northern (40?45&#9702; S) and Southern Patagonia (48?52&#9702; S) pollen sites locations, shifts on latitudinal and strength of the SWW results in large changes on hydric availability on forest and steppe communities. Therefore, we can interpret fossil pollen dataset as changes on paleohydric balance at every single site by the construction of paleohydric indices and comparison to charcoal records during the last 2000 cal yrsBP. Our composite pollen-based Northern and Southern Patagonia indices can be interpreted as changes in latitudinal variation and intensity of the SWW respectively. Dataset integration suggests poleward SWW between 2000 and 750 cal yrsBP and northward-weaker SWW during the Little Ice Age (750?200 cal yrsBP). These SWW variations are synchronous to Patagonian fire activity major shifts. We found an in phase fire regime (in terms of timing of biomass burning) between northern Patagonia Monte shrubland and Southern Patagonia steppe environments. Conversely, there is an antiphase fire regime between Northern and Southern Patagonia forest and forest-steppe ecotone environments. SWW variability may be associated to ENSO variability especially during the last millennia. For the last 200 cal yrs BP we can concluded that the SWW belt were more intense and poleward than the previous interval. Our composite pollen-based SWW indices show the potential of pollen dataset integration to improve the understanding of paleohydric variability especially for the last 2000 millennial in Patagonia.","palabras_clave":"Eastern Andean communities|pollen and charcoal analysis|last 2000 years BP|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19293,"idioma_id":4,"titulo":"A composition dependent energy scale and the determination of the cosmic ray primary mass in the ankle region","resumen":"At present there are still several open questions about the origin of the ultra high energy cosmic rays. However, great progress in this area has been made in recent years due to the data collected by the present generation of ground based detectors like the Pierre Auger Observatory and Telescope Array. In particular, it is believed that the study of the composition of the cosmic rays as a function of energy can play a fundamental role for the understanding of the origin of the cosmic rays.The observatories belonging to this generation are composed of arrays of surface detectors and fluorescence telescopes. The duty cycle of the fluorescence telescopes is $10% in contrast with the $100% of thesurface detectors. Therefore, the energy calibration of the events observed by the surface detectors is performed by using a calibration curve obtained from a set of high quality events observed in coincidence by both types of detectors. The advantage of this method is that the reconstructed energy of the events observed by the surface detectors becomes almost independent of simulations of the showers becausejust a small part of the reconstructed energy (the missing energy), obtained from the fluorescence telescopes, comes from simulations. However, the calibration curve obtained in this way depends on thecomposition of the cosmic rays, which can introduce biases in composition analyses when parameters with a strong dependence on primary energy are considered. In this work we develop an analytical method to study these effects. We consider AMIGA (Auger Muons and Infill for the Ground Array), the low energy extension of the Pierre Auger Observatory corresponding to the surface detectors, to illustrate the use of the method. In particular, we study the biases introduced by an energy calibration dependent on composition on the determination of the mean value of the number of muons, at a given distance to the showers axis, which is one of the parameters most sensitive to primary mass and has an almost lineardependence with primary energy.","palabras_clave":"Cosmic Rays|Energy Calibration|Chemical Composition"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19294,"idioma_id":4,"titulo":"Intersex in the gonochoristic crustacean Tanais dulongii (Audouin, 1826) (Peracarida: Tanaidacea: Tanaididae): a comparison of external reproductive characteristics","resumen":"Tanais dulongii (Audouin, 1826) is a small benthic crustacean with separate sexes and a marked sexual dimorphism characterized by a cephalothorax narrowed  anteriorly, larger chelae (claws) and a pair of tiny genital cones in males, and  ovisacs that form chambers for carrying embryos in females. Recent studies have  described the existence of intersexual individuals with a cephalothorax similar to males, large chelae and ovisacs, but, due to their small size, it has not been possible to confirm the presence of genital cones under normal light microscopy. The present study analyses and compares external reproductive structures under scanning electron microscopy, of male and female T. dulongii, to corroborate the presence of both ovisacs and genital cones in potentially intersex individuals. The possible causes, such as hermaphroditism, environmental sex determination, parasitism, genetic aberration or endocrine-disrupting pollutants, are discussed.","palabras_clave":"Tanaidacea|Tanais dulongii|intersex|genital cones|ovisacs"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19295,"idioma_id":4,"titulo":"Continental-scale analysis reveals deep diversification within the polytypic Red-crowned Ant Tanager (Habia rubica, Cardinalidae)","resumen":"We explored the phylogeographic patterns of intraspecific diversity in the Red-crowned Ant Tanager (Habia rubica) throughout its continent-wide distribution, in order to understand its evolutionary history and the role of evolutionary drivers that are considered to promote avian diversification in the Neotropics. We sampled 100 individuals of H. rubica from Mexico to Argentina covering the main areas of its disjunct distribution. We inferred phylogenetic relationships through Bayesian and maximum parsimony methodologies based on mitochondrial and nuclear markers, and complemented genetic analyses with the assessment of coloration and behavioral differentiation. We found four deeply divergent phylogroups within H. rubica: two South American lineages and two Mexican and Middle American lineages. The divergence event between the northern and southern phylogroups was dated to c. 5.0 Ma, seemingly related to the final uplift of the Northern Andes. Subsequently, the two South American phylogroups split c. 3.5 Ma possibly due to the development of the open vegetation corridor that currently isolates the Amazonian and Atlantic forests. Diversification throughout Mexico and Middle America, following dispersion across the Isthmus of Panama, was presumably more recent and coincident with Pleistocene climatic fluctuations and habitat fragmentations. The analyses of vocalizations and plumage coloration  showed significant differences among main lineages that were consistent with the phylogenetic evidence. Our findings suggest that the evolutionary history of H. rubica has been shaped by an assortment of diversification drivers at different temporal and spatial scales resulting in deeply divergent lineages that we recommend should be treated as different species.","palabras_clave":"AVES|DIVERSIFICATION|HABIA RUBICA|LOWLAND FORESTS|NEOTROPICS|PHYLOGENETICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19296,"idioma_id":4,"titulo":"Search for patterns by combining cosmic ray energy and arrival directions at the Pierre Auger Observatory","resumen":"Energy-dependent patterns in the arrival directions of cosmic rays are searched for using data of the Pierre Auger Observatory. We investigate local regions around the highest-energy cosmic rays with  E > 6x10^19  eV by analyzing cosmic rays with energies above  E > 5x10^18 eV arriving within an angular separation of approximately 15 degrees . We characterize the energy distributions inside these regions by two independent methods, one searching for angular dependence of energy-energy correlations and one searching for collimation of energy along the local system of principal axes of the energy distribution. No significant patterns are found with this analysis. The comparison of these measurements with astrophysical scenarios can therefore be used to obtain constraints on related model parameters such as strength of cosmic-ray deflection and density of point sources.","palabras_clave":"Astroparticle physics|Cosmic rays|Point sources|Pierre Auger Observatory"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19297,"idioma_id":4,"titulo":"Searches for Anisotropies in the Arrival Directions of the Highest Energy Cosmic Rays Detected  by the Pierre Auger Observatory","resumen":"P { margin-bottom: 0.21cm; }Weanalyze the distribution of arrival directions of ultra-high-energycosmic rays recorded at the Pierre Auger Observatoryin 10 years of operation. The data set, about three times larger thanthat used in earlier studies, includesarrival directions with zenith angles up to 80°, thus covering from -90ï?°to +45ï?°in declination. After updatingthe fraction of events correlating with the active galactic nuclei (AGNs)in the Véron-Cetty and Véron catalog,we subject the arrival directions of the data with energies in excessof 40 EeV to different tests for anisotropy.We search for localized excess fluxes, self-clustering of event directions at angular scales up to 30°, anddifferent threshold energies between 40 and 80 EeV. We then look forcorrelations of cosmic rays with celestialstructures both in the Galaxy (the Galactic Center and Galactic Plane)and in the local universe (the Super-GalacticPlane). We also examine their correlation with different populations ofnearby extragalactic objects: galaxiesin the 2MRS catalog, AGNs detected by Swift-BAT, radio galaxies withjets, and the Centaurus A (CenA)galaxy. None of the tests show statistically significant evidence of anisotropy. The strongest departures from isotropy(post-trial probability ~1.4%)are obtained for cosmic rays with E&gt;58EeV in rather large windows aroundSwift AGNs closer than 130 Mpc and brighter than 1044erg s&#8722;1(18°radius), and around the direction of CenA (15°radius)","palabras_clave":"ACCELERATION OF PARTICLES|ASTROPARTICLE PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19298,"idioma_id":4,"titulo":"An improved limit to the diffuse flux of ultra-high energy neutrinos from the Pierre Auger  Observatory","resumen":"Neutrinos in the cosmic ray flux with energies near 1 EeV and above are detectable with the Surface Detector array (SD) of the Pierre Auger Observatory. We report here on searches through Auger data from 1 January 2004 until 20 June 2013. No neutrino candidates were found, yielding a limit to the diffuse flux of ultrahigh energy neutrinos that challenges the Waxman-Bahcall bound predictions. Neutrino identification is attempted using the broad time structure of the signals expected in the SD stations, and is efficiently done for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for ?Earth-skimming? neutrino interactions in the case of tau neutrinos. In this paper the searches for downward-going neutrinos in the zenith angle bins 60°?75° and 75°?90° as well as for upward-going neutrinos, are combined to give a single limit. The 90% C.L. single-flavor limit to the diffuse flux of ultrahigh energy neutrinos with an E^&#8722;2 spectrum in the energy range 1.0×10^17&#8201;&#8201;eV?2.5×10^19&#8201;&#8201;eV is E2&#957;dN&#957;\/dE&#957;<6.4×10^&#8722;9&#8201;GeV&#8201;cm^-2&#8201;s^&#8722;1&#8201;sr^&#8722;1.","palabras_clave":"COSMIC RAYS|PIERRE AUGER OBSERVATORY|ULTRAHIGHT ENERGY NEUTRINOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19299,"idioma_id":4,"titulo":"Inhibition of NOS-NO System Prevents Autoimmune Orchitis Development in Rats: Relevance of NO Released by Testicular Macrophages in Germ Cell Apoptosis and Testosterone Secretion","resumen":"  Background   Although the testis is considered an immunoprivileged organ it can orchestrate immune responses against pathological insults such as infection and trauma.Experimental autoinmune orchitis(EAO)is a model of chronic inflammation whose main histopathological features it shares with human orchitis. In EAO an increased number of macrophages infiltrate the&nbsp; interstitium concomitantlywith progressive germ cell degeneration and&nbsp; impaired steroidogenesis.Up-regulation of nitric oxide(NO)-NOsynthase(NOS)system occurs, macrophages&nbsp;being the main producers of NO.Objective   The aim of our study was to evaluate the role of NO-NOS system in orchitis development and determine the involvement of NO released by testicular macrophages on germ cell apoptosis and testosterone secretion.Method andResults   EAO was induced in rats by immunization with testicular homogenate and adjuvants (E group)and a group of untreated normal rats(N) was also studied. Blockage of NOS byi.p. injection of E rats with a competitive inhibitor of NOS, L-NAME(8mg\/kg),significantly reduced the incidence and severity of orchitis and lowered testicular nitrite&nbsp; content.L-NAME reduced germ cell apoptosis and restored intratesticular testosterone levels,without variations in serum LH.Coculture of N testicular fragments with testicular macrophages obtained from EAO rats significantly increased germ cell apoptosis and testosterone secretion,whereas addition of L-NAME lowered both effects and reduced nitrite content.Incubation of testicular fragments from N rats with a NO donor DETA-NOnoate(DETA-NO) induced germ cell apoptosis through external and internal apoptotic pathways, an effect prevented byN-acetyl-L-cysteine (NAC).DETA-NO inhibited testosterone&nbsp; released from Leydigcells,whereas NAC(from 2.5to15mM) did not prevent this effect.Conclusions   We demonstrated that NO-NOS system is involved in the impairment of testicular function in orchitis.NO secreted mainly by testicular macrophages could promote oxidative stress inducing ST damage and interfering in Leydig cell function","palabras_clave":"NITRIC OXIDE|AUTOIMMUNE ORCHITIS|MACROPHAGES|APOPTOSIS|TESTOSTERONE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19300,"idioma_id":4,"titulo":"?\tDual roles of endogenous and exogenous galectin-1 in the control of testicular immunopathology","resumen":"Galectin-1 (Gal-1), a proto-type member of galectin family, is highly expressed in immune privileged sites, including the testis. However, in spite of  onsiderable progress the relevance of endogenous and exogenous Gal-1 in testis pathophysiology have not yet been explored. Here we evaluated the in vivo roles of Gal-1 in experimental autoimmune orchitis (EAO), a well-established model of autoimmune testicular inflammation associated with subfertility and infertility. A significant reduction in the incidence and severity of EAO was observed in mice genetically deficient in Gal-1 (Lgals1&#8722;\/&#8722;) versus wild-type (WT) mice. Testicular histopathology revealed the presence of multifocal testicular damage in WT mice characterized by an interstitial mononuclear cell infiltrate and different degrees of germ cell sloughing of seminiferous tubules. TUNEL assay and assessment of active caspase-3 expression, revealed the prevalence of apoptotic spermatocytes mainly localized in the adluminal compartment of seminiferous tubules in EAO mice. A significant increased number of TUNEL-positive germ cells was detected in EAO testis from WT compared with Lgals1&#8722;\/&#8722; mice. In contrast, exogenous administration of recombinant Gal-1 to WT mice undergoing EAO attenuated the severity of the disease. Our results unveil a dual role of endogenous versus exogenous Gal-1 in the control of autoimmune testis inflammation.","palabras_clave":"Galectin|Testis|Experimental Autoimmune Orchitis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19301,"idioma_id":4,"titulo":"ASSESSMENT OF GROUNDWATER RECHARGE AND DISCHARGE PROCESSES  IN A LOESSICAL AQUIFER USING A NEW COMPUTER CODE","resumen":"Rio Cuarto city and its rural surrounding area (400 km2) shows two major geological environments,formed by eolian and fluvial sediments. The main source of groundwater recharge is precipitation (P),with an annual mean rainfall of 799 mm; 75-80% concentrated in spring and summer. The aim of this paper is to show the water table behavior in the unconfined eolian aquifer (very fine sands and silts) taking into consideration recharge (R) and discharge (D) events. R was calculated using the watertable fluctuation method for a selected period (2002-2009) with a new computer code Likqo 1.0. Therecharge was estimated for both the hydrologic and calendar year. The first result was better according to the higher R-P regression coefficient obtained. It is important to highlight the recharge delay (daysor weeks) in relation to rain storms; a fact that can be linked to water table depth. The average R value for the entire series was 12% of P, the largest recharge occurring in the hydrologic periods 2002-2003  and 2007-2008 (14% P) and the lowest in 2004-2005 (10 % P).  The ratio R\/D for the total series was slightly negative, which means that aquifer discharge was  dominant, coinciding with the lowest position of the water table.","palabras_clave":"ACUIFERO LIBRE|RECARGA|COMPUTER CODE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19302,"idioma_id":4,"titulo":"Comparison of the microbial communities of hot springs waters and the microbial biofilms in the acidic geothermal area of Copahue (Neuquen, Argentina)","resumen":"Copahue is a natural geothermal field (Neuquén province, Argentina) dominated by the Copahue volcano. As a consequence of the sustained volcanic activity Copahue presents many acidic pools, hot springs and solfataras with different temperature and pH conditions that influence their microbial diversity. The occurrence of microbial biofilms was observed on the surrounding rocks and the borders of the ponds, where water movements and thermal activity are less intense. Microbial biofilms are particular ecological niches within geothermal environments; they present different geochemical conditions from that found in the water of the ponds and hot springs which is reflected in different microbial community structure. The aim of this study is to compare microbial community diversity in the water of ponds and hot springs and in microbial biofilms in the Copahue geothermal field, with particular emphasis on cyanobacteria and other photosynthetic species that have not been detected before in Copahue. In this study we report the presence of Cyanobacteria, Chloroflexi and chloroplast of eukaryotes in the microbial biofilms not detected in the water of the ponds. On the other hand, acidophilic bacteria, the predominant species in the water of moderate temperature ponds, are almost absent in the microbial biofilms in spite of having in some cases similar temperature conditions. Species affiliated with Sulfolobales in the Archaea domain are the predominant microorganism in high temperature ponds and were also detected in the microbial biofilms.","palabras_clave":"GEOTHERMAL FIELD|ACIDIC ENVIRONMENT|MICROBIAL BIOFILM|EXTREME ENVIRONMENT BIODIVERSITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19303,"idioma_id":4,"titulo":"Zinc recovery during refractory ore biooxidation by an indigenous consortium","resumen":"Two enrichment cultures (one iron oxidizing and one sulfur oxidizing) obtainedfrom an acid mine drainage were physiological and molecular characterized;the first of them showed 99% 16S rRNA gene sequence similarity withLeptospirillum ferrooxidans, while the sulfur oxidizing species was highlyrelated to Acidithiobacillus ferrooxidans and Acidithiobacillus ferrivoranssequences although, unlike them, the species in the enrichment culture doesnot seem to be able to oxidize iron. The consortium constituted by bothenrichment cultures achieved a successful biooxidation of Hualilan oreallowing the increase of gold recovery up to 96.4 % in the best culturecondition (low pulp density in 1K medium). At the same time, this conditionshowed an effective zinc bioleaching (up to 86 %) although the recovery wasmuch higher in cultures with initially supplemented iron; kinetics studiessuggested that bioleaching rate in 1K medium at low pulp densities iscontrolled by diffusion through a layer mainly constituted by jarosite (ratherthan sulfur) which was detected in X-ray diffraction diagrams. The recovery ofzinc as subproduct of the pretreatment to optimize gold recovery would alsoallow decrease the metallic charge of the leachates from the biooxidationtanks which is an environmental advantage.","palabras_clave":"Zinc bioleaching|Biooxidation|Gold recovery|Indigenous consortia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19304,"idioma_id":4,"titulo":"Thermophiles in the genomic era: Biodiversity, science, and applications","resumen":"Thermophiles and hyperthermophiles are present in various regions of the Earth, including volcanic environments, hot springs, mud pots, fumaroles, geysers, coastal thermal springs, and even deep-sea hydrothermal vents. They are also found in man-made environments, such as heated compost facilities, reactors, and spray dryers. Thermophiles, hyperthermophiles, and their bioproducts facilitate various industrial, agricultural, and medicinal applications and offer potential solutions to environmental damages and the demand for biofuels. Intensified efforts to sequence the entire genome of hyperthermophiles and thermophiles are increasing rapidly, as evidenced by the fact that over 120 complete genome sequences of the hyperthermophiles Aquificae, Thermotogae, Crenarchaeota, and Euryarchaeota are now available. In this review, we summarise the major current applications of thermophiles and thermozymes. In addition, emphasis is placed on recent progress in understanding the biodiversity, genomes, transcriptomes, metagenomes, and single-cell sequencing of thermophiles in the genomic era.","palabras_clave":"EXTREMOPHILES|APPLICATIONS|BIODIVERSITY|THERMOPHILES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19305,"idioma_id":4,"titulo":"Comparative Analysis of Performance and Quality of Prediction Between ESS and ESS-IM","resumen":"Wildfires cause major damage and losses around the world. Such damages range from human and economical losses to environmental ones. Therefore, having models to predict their behavior can be a key element in the process of firefighting. In this paper, we present a comparative study between two methods we have developed. Both methods use Statistical Analysis, Parallel Evolutionary Algorithms and High Performance Computing, respectively named: Evolutionary-Statistical System (ESS) and Evolutionary-Statistical System with Island Model (ESS-IM). In this study, we have compared these two methods in terms of quality of prediction and performance in the parallel environment.","palabras_clave":"WILDFIRES PREDICTION|SPEED-UP|EVOLUTIONARY ALGORITHMS|HIGH PERFORMANCE COMPUTING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19306,"idioma_id":4,"titulo":"Variations in macrobenthic community structure in relation to changing environmental conditions in sandy beaches of Argentina","resumen":"This study describes for the first time the intertidal macrobenthic community of exposed sandy beaches located near the Bahía Blanca Estuary (38°S) and reports the physical characterization of this coastal fringe. The main objective of the study was to link environmental variables to biotic information, analyzing the results in the context of the Swash Exclusion Hypothesis (SEH) and possible estuarine influence. Four beaches were sampled seasonally at different distances from the mouth of the Bahía Blanca Estuary. To characterize the morphodynamic state of the beaches, the Dean parameter (&#937;) was calculated. Multivariate analyses were used to assess benthic community structures and their relationships with physical variables. The two beaches located closest to the Bahía Blanca Estuary were classified as intermediate and those located further from the estuary as dissipative. Richness, diversity and biomass of intertidal macrobenthic communities varied with the SEH, increasing towards the dissipative beaches. However, total density was higher on intermediate beaches, possibly because of nutrient-rich silt-clay sediment input from the estuary, enabling them to maintain a higher density of organisms than dissipative beaches. The estuary acts as a moderator of habitat hardness, which together with the morphodynamic state of the beaches is an important factor in the structuring of the macrobenthic community along this coastal fringe.","palabras_clave":"BEACHES|BENTHOS|ESTUARINE FRONT|MORPHODYNAMICS|TEMPERATE ZONES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19307,"idioma_id":4,"titulo":"Fast Distributed Dynamics of Semantic Networks via Social Media","resumen":"We investigate the dynamics of semantic organization using social media, a collective expression of human thought. We propose a novel, time-dependent semantic similarity measure (TSS), based on the social network Twitter. We show that TSS is consistent with static measures of similarity but provides high temporal resolution for the identification of real-world events and induced changes in the distributed structure of semantic relationships across the entire lexicon. Using TSS, we measured the evolution of a concept and its movement along the semantic neighborhood, driven by specific news\/events. Finally, we showed that particular events may trigger a temporary reorganization of elements in the semantic network.","palabras_clave":"semantic embedding|machine learning|twitter|semantic similarity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19308,"idioma_id":4,"titulo":"Quantitation of Yeast Cell-Cell Fusion Using Multicolor Flow Cytometry","resumen":"Mating of haploid Saccharomyces cerevisiae cells of opposite sex provides a powerful model system to study the cell?cell fusion. However, a rapid and standardized method is much needed for quantitative assessment of fusion efficiency. The gold standard method relies on counting mating pairs in fluorescence microscopy images. This current method is limited by expectancy bias and it is time consuming, restricting the number of both cell?cell fusion events and strains that can be analyzed at once. Automatic approaches present a solution to these limitations. Here, we describe a novel flow cytometric approach that is able to quickly both identify mating pairs within a mixture of gametes and quantify cell fusion efficiency. This method is based on staining the cell wall of yeast populations with different Concanavalin A?fluorophore conjugates. The mating subpopulation is identified as the two-colored events set and fused and unfused mating pairs are subsequently discriminated by green fluorescent protein bimolecular complementation. A series of experiments was conducted to validate a simple and reliable protocol. Mating efficiency in each sample was determined by flow cytometry and compared with the one obtained with the current gold standard technique. The results show that mating pair counts using both methods produce indistinguishable outcomes and that the flow cytometry-based method provides quantitative relevant information in a short time, making possible to quickly analyze many different cell populations. In conclusion, our data show multicolor flow cytometry-based fusion quantitation to be a fast, robust, and reliable method to quantify the cell?cell fusion in yeast","palabras_clave":"yeast|fertilization|High-throughput|genetics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19309,"idioma_id":4,"titulo":"Synthetic Crossfeeding Cocultures in Yeast: Computational Model of Autoregulation and Design of  a Tryptophan Export Device","resumen":"n order to contribute to the design of crossfeeding systems, we modeled population control in a coculture of two crossfeeding strains of an organism, each of which secretes a metabolite the other strain requires to grow. Differential equations show that the steady-state population ratio can be tuned by varying the ratio of the metabolite secretion rates, as long as they fall within a range determined by the nature of the organism. Numerical simulations of Trp\/His crossfeeding in budding yeast suggest that the time required to reach steady state populations critically depends on the capacity of the cells to uptake the crossfeeding amino acids. We also engineered and evaluated a novel genetic device that secretes tryptophan-rich peptides with a cell penetrating sequence. Experimental validation showed that the device increases tryptophan secretion and enables growth of a trp&#8722; strain in a coculture in synthetic medium lacking tryptophan.","palabras_clave":"crossfeeding systems|yeast|population|synthetic biology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19311,"idioma_id":4,"titulo":"Neutron Irradiation of U3Si5 and Al43Mo4U6 Compounds. First Results","resumen":"In the framework of U(Mo) alloys qualification used as nuclear fuel for research reactors, post-irradiation experiments have shown that the porosity and swelling phenomena observed due to irradiation on dispersed fuel elements are associated to a poor behavior of the interaction layer grown by interdiffusion during fabrication and\/or irradiation between U(Mo) particles and the matrix. Fission induced amorphization of some of the phases that form the interaction layer, has been proposed as one explanation to understand the failure. Out of pile diffusion couples experiments have shown that the phases UAl3, UAl4,Al20Mo2U and Al43Mo4U6 form the interaction layer when pure Al is used as matrix while U(Al,Si)3, U3Si5, USi2, USi2-x, Al20Mo2U and Al43Mo4U6 are identified when Al(Si) is used instead of Al. The objective of this investigation is to study,independently, the behavior of each phase under neutron irradiation focusing on a possible amorphization. In this work, powders of U3Si5 and Al43Mo4U6 compounds were irradiated at RA1 reactor (Argentina). Samples were analyzed by optical microscopy, scanning electron microscopy, energy dispersive spectroscopy, wavelength dispersive spectroscopy and X-ray diffraction.","palabras_clave":"nuclear fuel|irradiation|U alloys"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19312,"idioma_id":4,"titulo":"Effect of arsenic on reflectance spectra and chlorophyll fluorescence of aquatic plants","resumen":"Arsenic pollution of groundwater is a serious problem in many regions of Latin America that causes severe risks to human health. As a consequence, non-destructive monitoring methodologies, sensitive to arsenic presence in the environment and able to perform a rapid screening of large polluted areas,are highly sought-after. Both chlorophyll ? a fluorescence and reflectance of aquatic plants may be potential indicators to sense toxicity in water media.In this work, the effects of arsenic on the optical and photophysical properties of leaves of different aquatic plants (Vallisneria gigantea, Azolla filiculoides and Lemna minor) were evaluated. Reflectance spectra were recorded for the plant leaves from 300 to 2400 nm. The spectral distribution of the fluorescencewas also studied and corrected for light re-absorption processes. Photosynthetic parameters (Fv\/Fm and UPSII) were additionally calculated from the variable chlorophyll fluorescence recorded with a pulse amplitude modulated fluorometer.Fluorescence and reflectance properties for V. gigantea and A. filiculoides were sensitive to arsenic presence in contrast to the behaviour of L. minor. Observed changes in fluorescence spectra could be interpreted in terms of preferential damage in photosystem II. The quantum efficiency of photosystem II for the first two species was also affected, decreasing upon arsenic treatment. As a result of this research, V. gigantea and A. filiculoides were proposed as bioindicators of arsenic occurrence in aquatic media.","palabras_clave":"CHLOROPHYLL FLUORESCENCE|REFLECTANCE |ARSENIC|ENVIRONMENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19313,"idioma_id":4,"titulo":"Strategic applications of long-acting acaricides against Rhipicephalus (Boophilus) microplus in northwestern Argentina, with an analysis of tick distribution among cattle.","resumen":"tStrategic applications of long-acting acaricides for the control of Rhipicephalus (Boophilus)microplus in northwestern Argentina were evaluated for one year. In addition, tick distri-bution among cattle was analyzed to evaluate if partial selective treatment or culling thesmall proportion of most heavily infested animals were feasible options to control R. (B.)microplus. Two different treatments schemes based on two applications of fluazuron andone application of 3.15% ivermectin were performed. Treatments were made in late winterand spring so as to act on the small 1st spring generation of R. (B.) microplus, in order to pre-clude the rise of the larger autumn generation. The overall treatment effect was positivelysignificant in both schemes. The number of ticks observed in the control group was signif-icantly higher than in the treated groups on all post-treatment counts. Group 2 exhibitedmore than 80% of efficacy almost throughout the study period, whereas Group 1 exhib-ited an efficacy percentage higher than 80% in September, October, December, February,April and May, but not in November (73.4%), January (58.3%), March (45.2%) or June (53.4%).Absolute control was observed in Group 2 in the counts of September and October, and inGroup 1 in the count of February. The control strategies evaluated in this work provide anacceptable control level with only three applications of acaricides; at the same time, theyprevent the occurrence of the autumn peak of tick burdens, which is characteristic of R.(B.) microplus in northwestern Argentina. Tick distribution was markedly aggregated in allcounts. Although ticks were not distributed evenly among calves, the individual compo-sition of the most heavily infested group was not consistent throughout the study period.In addition, the level of aggregation varied with tick abundance. These results suggest thatapplying acaricides to a portion of the herd or culling the most infested individuals at agiven moment of the year may not be proper methods to achieve a significant control of R.(B.) microplus in northwestern Argentina.","palabras_clave":"RHIPICEPHALUS MICROPLUS|CONTROL|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19314,"idioma_id":4,"titulo":"The taxonomic status of Rhipicephalus sanguineus (Latreille, 1806)","resumen":"tThe brown dog tick, Rhipicephalus sanguineus sensu stricto, is a species with considerablepublic health and economic importance. However, the taxonomic status of this species is farfrom resolved. After more than 110 years of scientific work on R. sanguineus s.s., the situationis that there is no type, no solid description, nor is there a consensus about the range ofmorphological variability within the species. Recent findings based on laboratory crossesand molecular genetics strongly suggest that there are several entities grouped under thesame name. Here we review the history of the taxon, and we point out the caveats behindany further work on this tick. The current taxonomic status of R. sanguineus s.s. thus lacksan informative original description, and is based on the existence of several morphologicaldescriptions based on ticks originating from different populations, which show, in somecases, biological incompatibility and significant genetic divergence. We suggests that asa result it is not possible to assign the specific name R. sanguineus s.s. to any population.Further work is required based on the rules issued by the International Code of ZoologicalNomenclature to clearly define the morphological range of the different populations.","palabras_clave":"RHIPICEPHALUS SANGUINEUS|TAXONOMY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19315,"idioma_id":4,"titulo":"Two new species of Ornithodoros (Ixodida; Argasidae) from the Southern Cone of South America","resumen":"Two new species of the genus Ornithodoros were described from larvae collectedin Argentina and Chile. Ornithodoros xerophylus n. sp. was described from specimenscollected on the small rodent Graomys centralis in Argentina. The diagnosticcharacters for this species are a combination of dorsal plate slightly oval with a length ofapproximately 250 lm, 16 pairs of dorsal setae, hypostome with apex rounded and dentalformula 2\/2 in most rows, 3\/3 apically, and capsule of the Haller?s organ oval in shapewithout reticulations. Larvae of Ornithodoros lahillei n. sp. were collected on the reptilesPhilodryas chamissonis and Callopistes maculatus in Chile. The diagnostic characters forO. lahillei are a combination of dorsal plate subtriangular with margins corrugated andposterior margin convex, dorsal surface with 14 pairs of setae, absence of postcoxal setae,and hypostome with apex pointed and dental formula 3\/3 in anterior third and 2\/2 in themiddle and basal portion. Phylogenetic analysis of 16S rDNA sequences and a PrincipalComponent Analysis based on morphometric characters provided additional support to thedescription of O. lahillei and O. xerophylus as two independent lineages within the genusOrnithodoros.","palabras_clave":"ORNITHODOROS|NEW SPECIES|ARGENTINA|CHILE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19316,"idioma_id":4,"titulo":"Unaffected features of BSA stabilized Ag nanoparticles after storage and reconstitution in biological relevant media","resumen":"Silver-coated orthopedic implants and silver composite materials have been proposed to produce local biocidal activity at low dose to reduce post-surgery infection that remains one of the major contributions to the patient morbidity. This work presents the synthesis combined with the characterization, colloidal stability in biological relevant media, antimicrobial activity and handling properties of silver nanoparticles (Ag-NP) before and after freeze dry and storage. The nanomaterial was synthesized in aqueous solution with simple, reproducible and low-cost strategies using bovine serum albumin (BSA) as the stabilizing agent. Ag-NP were characterized by means of the size distribution and morphology (UV?vis spectra, dynamic light scattering measurements and TEM images), charge as a function of the pH (zeta potential measurements) and colloidal stability in biological relevant media (UV?vis spectra and dynamic light scattering measurements). Further, the interactions between the protein and Ag-NP were evaluated by surface enhanced Raman spectroscopy (SERS) and the antimicrobial activity was tested with two bacteria strains (namely Staphylococcus aureus and Staphylococcus epidermidis) mainly present in the infections caused by implants and prosthesis in orthopedic surgery. Finally, the Ag-NP dispersed in aqueous solution were dried and stored as long-lasting powders that were easily reconstituted without losing their stability and antimicrobial properties. The proposed methods to stabilize Ag-NP not only produce stable dispersions in media of biological relevance but also long-lasting powders with optimal antimicrobial activity in the nanomolar range. This level is much lower than the cytotoxicity determined in vitro on osteoblasts, osteoclasts and osteoarthritic chondrocytes. The synthesized Ag-NP can be incorporated as additive of biomaterials or pharmaceutical products to confer antimicrobial activity in a powdered form in different formulations, dispersed in aqueous and non-aqueous solutions or coated on the surface of different materials.","palabras_clave":"Bovine serum albumin|Silver nanoparticle|Stabilization mechanism|Colloidal stability|Antimicrobial activity|Freeze dry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19317,"idioma_id":4,"titulo":"Estimating shallow water table contribution to soybean water use in Argentina","resumen":"The existence of a shallow water table can be an important water  source for rainfed agricultural production. The objective of this study is to quantify the water contribution of the water table to soybean water  requirements in the center of Argentina by means of a crop simulation model that relates water balance to grain production. The model was calibrated and validated considering soil water records up to 1 m deep, and the oscillation in the water table depth and grain yield during two climatically contrasted growth seasons (2004\/05 - 2005\/06). The adjustment obtained between observed and simulated values was: 1.8 mm for soil humidity, between 0.26 and 0.01 m for oscillation of the water table and between 49 and 920 kg ha-1 for grain yield. The results obtained with the simulation indicate that the water table contributed between 12 and 30% of the total water used by the crop in each growing season studied. It was concluded that, in rainfed agricultural conditions, a water table oscillating between 1.5 and 2 m deep makes it possible to stabilize the yield of rainfed soybean.","palabras_clave":"WATER TABLE|CROP SIMULATION MODEL|WATER BALANCE|SOYBEAN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19318,"idioma_id":4,"titulo":"Polar varieties, Bertini's theorems and number of points of singular complete intersections over afinite field","resumen":"Let V &#8834; P^{n}(Fq ) be a complete intersection defined over a finite field Fq of dimension r and singular locus of dimension at most s, and let &#960; : V --&gt; P^{s+1} (Fq ) be a generic linear mapping. We obtain an effective version of the Bertini smoothness theorem concerning &#960;, namely an explicit upper bound of the degree of a proper Zariski closed subset ofP^{s+1} (Fq ) which contains all the points defining singular fibersof &#960;. For this purpose we make use of the concept of polar variety associated with the set of exceptional points of &#960;. As a consequence, we obtain results of existence of smooth rational points of V , that is, conditions on q which imply that V has a smooth Fq -rational point. Finally, for s = r &#8722; 2 and s = r &#8722; 3 we estimate the number of Fq -rational points and smooth Fq -rational points of V .","palabras_clave":"VARIETIES OVER FINITE FIELDS|RATIONAL POINTS|SINGULAR LOCUS|BERTINI SMOOTHNESS THEOREM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19319,"idioma_id":4,"titulo":"Regeneration rate after fission in the fissiparous sea star Allostichaster capensis (Asteroidea)","resumen":"Many studies have focused on the regeneration rate of arms in Asteroidea but no studies have focusedon the regeneration rate after fission. Allostichaster capensis is a fissiparous sea star with a wide range of distribution.In Golfo Nuevo (42°46?49?? S - 64°59? 26?? W) sea stars undergo fission every spring and summerand regenerate the rest of the year. To analyze the regeneration rate, we conducted an experiment with sea starscollected just before fission. After sea stars underwent fission, the length of the three non-regenerating and thethree regenerating arms were measured weekly. The arm length (regenerating and non-regenerating) was usedin non-Linear Mixed Effect models in order to account for within-individual correlation in different models.The regenerating arms regenerate according to a Quadratic model, while the non-regenerating arms regenerateaccording to a linear model. In the regenerating arms, the regeneration rate was estimated to be 0.1 mm.week-1and in the non-regenerating arms, the growth rate was 0.004 mm.week -1. Sea stars regenerate ca. 20 % of thearm in one month, and it takes about 5 months to be completely regenerated. At the beginning, the regenerationrate is fast generating the growth of the arms, once the pyloric caeca and gonads are present inside the arms theregeneration rate slows down probably due to allocation to gametes and pyloric caeca and arms. The factorsthat regulate the regeneration rate are unknown. However, food availability and energy storage seem to play animportant role.","palabras_clave":"REGENERATION RATE|FISSION|ASTEROIDEA|MIXED-MODEL EFFECTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19320,"idioma_id":4,"titulo":"Disturbance induced changes in species and functional diversity in southern Patagonian forest-steppe ecotone","resumen":"Ecotone areas are the most dynamic areas of the world where small changes in some condition produce rapid and abrupt responses such as shifts in the distribution of dominant species and associated community?s patches. Studying southwestern Santa Cruz forest-steppe ecotone is an ideal landscape to explore potential feedbacks of grazing and fire on vegetation diversity because of the juxtaposition of fire-resistant forests dominated by obligate seedlers with fire-sprouting shrublands and the revalence of wild cattle since the early XX century. In this study, we analyzed how climate (precipitation, temperature and water balance), stand characteristics (basal area, quantity of cohorts and exotic species cover) and disturbances (fire and grazing) affect native species diversity, Plant Functional Types (PFTs) diversity and PFTs response in the forest-steppe ecotone of southern Patagonia. The study was conducted on 124  plots located on the eastern slope of the Andes (between 48 and 50S) including forest-steppe ecotone sites between 1000 and 400 mm of annual precipitation. Native species and PFTs diversity indices modeling were carried out by generalized least squares and generalized lineal models. Stand characteristics, disturbance type and climate variables were used as factors over native species and PFTs diversity variables. An ordination and a Spearman rank correlation analysis were achieved between scores of the two first axes with total basal area, exotic species cover, mean annual temperature, annual precipitation, and water balance in order to explore PFTs responses to biotic or abiotic ecological conditions. The relationship between native species and PFTs richness (number of PFTs per plot) was modeled in order to evaluate the redundancy degree of PFTs under different disturbance types by fitting nonlinear power models to both richness measurements for each disturbance type. Fire impact over forest-steppe ecotone communities is one of the most important top down factor driving major increases on PFTs redundancy and heliophilous plants species abundance. At stand level, multicohort fire-disturbed stands support the highest native species diversity. Thus, mimicking this natural pattern on silvicultural practices could safeguard higher understory native species diversity than managing policies creating homogeneous conditions. Even if closed forest communities present lower native species diversity values than open canopy communities, they sustain different PFTs that present high conservation values for forest fauna. Grazing pressure represents a threatening agent diminishing native forest-steppe biodiversity. The coexistence of different stands at different development stages in the same landscape ensures the seed bank pools of shade tolerant and heliophilous species.","palabras_clave":"SPECIES DIVERSITY|FUNCTIONAL DIVERSITY|DISTURBANCE|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19321,"idioma_id":4,"titulo":"Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties","resumen":"Fusedheterobicyclic systems have gained much importance in the field of medicinalchemistry because of their broad spectrum of physiological activities. Amongthe heterocyclic rings containing bridgehead nitrogen atom, imidazothiazolesderivatives are especially attractive because of their different biological activities.Since manyimidazothiazoles derivatives are effective for treating several diseases, isinteresting to analyze the behavior of some isosteric related heterocycles,such as pirrolothiazoles, imidazothiadiazoles and imidazotriazoles. In thiscontext, this review summarizes the current knowledge about the syntheses andbiological behavior of these families of heterocycles. Traditional syntheticmethodologies as well as alternative synthetic procedures are described. Amongthese last methodologies, the use of multicomponent reaction, novel and efficientcoupling reagents, and environmental friendly strategies, like microwave assistanceand solvent-free condition in ionic liquids are also summarized. This reviewincludes the biological assessments, docking research and studies of mechanismof action performed in order to obtain the compounds leading to the developmentof new drugs.","palabras_clave":"IMDAZO[2,1-b]THIAZOLES|IMIDAZO[2,1-b][1,3,4]THIADIAZOLES|IMIDAZO[2,1-c][1,2,4]TRIAZOLES|PYRROLO[2,1-b]THIAZOLES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19322,"idioma_id":5,"titulo":"Acumulación y Control en el Circuito Productivo de la vid en San Juan, Argentina.","resumen":"El proceso de apertura, ajuste en la economía argentina de los años noventa primero y la postdevaluación posteriormente, han producido una acelerada y profunda transformación en las economías regionales, en sus actividades productivas y en la recomposición estructural y funcional de sus agentes.   Este trabajo tiene como objetivo principal analizar la dinámica de acumulación en el circuito productivo vitivinícola sanjuanino, entre 1990 y 2010. La categoría central es la de circuito productivo, enmarcado en el enfoque territorial.   Se describen las características de los agentes que integran el circuito, propietarios y no propietarios de los medios de producción, los rasgos que caracterizan las relaciones entre ellos para delimitar  la dinámica en general del circuito productivo vitivinícola sanjuanino.","palabras_clave":"TERRITORIO|ACUMULACIÓN|CONTROL|SUBORDINACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19323,"idioma_id":5,"titulo":"Inventario y estimación de la riqueza específica de artrópodos en bosques del Noreste de Argentina","resumen":"El propósito de este estudio es realizar un relevamiento, estimación y comparación de la riqueza de especies de artrópodos entre los ambientes de Chaco Húmedo, Selva Paranaense y de la Isla Apipé Grande en la provincia de Corrientes. Se realizaron dos muestreos en 15 parches de bosques en el área de estudio, cinco en cada uno de los ambientes considerados, las muestras se tomaron con un G-Vac (garden-vacum) sobre vegetación. Se recolectaron 19.348 artrópodos de 1.242 morfoespecies. Los inventarios obtenidos en cada ambiente superaron el 74% alcanzando un 87% de completitud en el área de estudio. La Selva Paranaense es la que presentó una mayor abundancia y riqueza de especies en comparación con el Chaco Húmedo y la Isla Apipé Grande. Arañas, coleópteros, dípteros, hemípteros e himenópteros representaron el 90% de las especies registradas en todo el muestreo, obteniendo los mayores valores de diversidad. Estos grupos son considerados como indicadores de diversidad y responden a varios aspectos de la heterogeneidad del hábitat.","palabras_clave":"ARTROPODOS|BIODIVERSIDAD|ARGENTINA|CORRIENTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19324,"idioma_id":4,"titulo":"The Hegetotheriidae (Mammalia, Notoungulata) assemblage from the late Oligocene of Mendoza, central-western Argentina","resumen":"?This study describes new remains of Hegetotheriidae (Notoungulata), including a new species, from the Deseadan (late Oligocene) of Quebrada Fiera, Mendoza Province, Argentina. The assemblage is composed of four hegetotheriines, Prohegetotherium cf. P. sculptum, Prohegetotherium sp., Prohegetotherium schiaffinoi, and Prohegetotherium malalhuense, sp. nov., and the pachyrukhine Propachyrucos cf. P. simpsoni. The presence of Prosotherium cannot be totallydiscounted because lower molariforms are rather similar between the two pachyrukhine genera. The new species Prohegetotherium malalhuense, sp. nov., differs from all previously described hegetotheriines by having a lingually projecting, sharp parastyle and marked parastyle groove on the ectoloph of M2?3; talonid of m1?2 posterolabially projected; talonid of m3 with marked posterolabial groove; and the smaller size. Its phylogenetic affinities are not well resolved. Prohegetotherium is paraphyletic, with P. sculptum sister taxon to the remaining hegetotheres, and the new taxon more closely related toHegetotherium mirabile than to P. schiaffinoi. The recognition of P. schiaffinoi and Prohegetotherium cf. P. sculptum emphasizes that the fauna from Quebrada Fiera shares elements with roughly contemporaneous Deseadan faunas fromnorthern and southern latitudes, but important faunal particularities distinguish the region as well. The record of pachyrukhines at Quebrada Fiera more closely resembles Deseadan faunas in Patagonia than temporally correlative faunas from Bolivia and Uruguay, and indicates the presence of suitable habitats in mid-latitudes of Argentina for this hypselodont clade. Faunal affinities together with particular taxa from Quebrada Fiera appear to support a significant faunal provinciality in South America during the late Oligocene.","palabras_clave":"Notoungulata|Hegetotheriidae|Oligocene|Mendoza"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19325,"idioma_id":4,"titulo":"A polyhedral approach to locating-dominating sets in graphs","resumen":"The locating-dominating set problem is a special domination problem, challengingboth from a theoretical and a computational point of view. Hence, a typical lineof attack is to determine minimum locating-dominating sets of special graphs or toprovide bounds for their size. Here, we study the locating-dominating set problemfrom a polyhedral point of view and demonstrate how the associated polyhedra canbe entirely described for some basic families of graphs. The latter enables us todetermine minimum weight locating-dominating sets in the studied graph classesfor arbitrary integral node weights. We discuss further lines of research in orderto apply similar techniques for other graph classes, to obtain the exact values orstrong lower bounds for the size of minimum locating-dominating sets, stemmingfrom linear relaxations of the polyhedra, enhanced by suitable cutting planes.","palabras_clave":"set covering|locating-dominating set|facet descriptions of polyhedra"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19326,"idioma_id":4,"titulo":"Immunization with Brucella VirB proteins elicits a protective Th1 immune response in mice and 1 a similar immune response in dogs","resumen":"VirB proteins from Brucella spp. constitute the type IV secretion system, a key virulence factor mediating the intracellular survival of these bacteria. Here, we assessed whether a Th1-type immune response against VirB proteins may protect mice from Brucella infection and whether this response can be induced in the dog, a natural host for Brucella. Splenocytes from mice immunizedwith VirB7 or VirB9 responded to their respective antigens with significant and specific production of gamma interferon (IFN-), whereas interleukin-4 (IL-4) was not detected. Thirty days after an intraperitoneal challenge with live Brucella abortus, the spleen load of bacteria was almost 1 log lower in mice immunized with VirB proteins than in unvaccinated animals. As colonization reduction seemed to correlate with a Th1-type immune response against VirB proteins, we decided to assesswhether such a response could be elicited in the dog. Peripheral blood mononuclear cells&nbsp; (PBMCs) from dogs immunized with VirB proteins (three subcutaneous doses in QuilA adjuvant) produced significantly higher levels of IFN- than cells from control animals upon in vitro stimulation with VirB proteins. A skin test to assess specific delayed-type hypersensitivity was positivein 4 out of 5 dogs immunized with either VirB7 or VirB9. As both proteins are predicted to locate in the outer membrane of Brucella organisms, the ability of anti-VirB antibodies to mediate complement-dependent bacteriolysis of B. canis was assessed in vitro. Sera from dogs immunized with either VirB7 or VirB9, but not from those receiving phosphate-buffered saline (PBS), produced significant bacteriolysis. These results suggest that VirB-specific responses that reduce organ colonization by Brucella in mice can be also elicited in dogs.","palabras_clave":"INMUNOLOGIA|VACCINE|BRUCELLA|CANINO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19327,"idioma_id":4,"titulo":"SILVER DEPOSITION ON POLYPYRROLE FILMS ELECTROSYNTHESISED ONTO NITINOL ALLOY.   CORROSION PROTECTION AND ANTIBACTERIAL ACTIVITY","resumen":"    Polypyrrole (PPy) coatings were  electrosynthesised onto Nitinol from sodium salicylate (NaSa) solutions of  different concentrations. The morphology and corrosion protection properties of  the resulting coatings depend on the NaSa concentration. The immobilisation of silver species  in PPy films constituted by hollow rectangular microtubes of PPy was studied as  a function of the polymer oxidation degree. The best results were obtained when  the coated electrode was polarised at ? 1.00 V(SCE) before silver deposition.  Finally, the antibacterial activity of the coating against the Grampositive Staphylococcus aureus and Staphylococcus epidermidis bacteria was  evaluated.  ","palabras_clave":"NITINOL|SILVER|POLYPYRROLE|ELCTROPOLYMERIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19328,"idioma_id":4,"titulo":"Does the stoichiometric carbon:phosphorus knife edge apply for predaceous copepods?","resumen":"Recent work has indicated that stoichiometric food quality in terms of carbon:phosphorus (C:P) ratios affects consumers whether the imbalance involves a deficit or an excess of nutrients; hence, organisms exist on a ?stoichiometric knife edge?. While previous studies have focused primarily on autotroph-herbivore trophic transfer, nutritional imbalances might also affect the interactions between species at higher trophic levels. Since the foods of carnivores are normally stoichiometrically similar to their own body composition, they may be more severely affected than herbivores if imbalances do become pronounced. We analysed the response of the predatory copepod Parabroteas sarsi to monospecific diet treatments consisting of high and low C:P prey items. These dietary treatments strongly affected the predators? elemental composition and growth, although prey selection, excretion, egestion, and respiration rates were not affected. We suggest that, due to their low threshold elemental ratio and a narrow C:P stoichiometric knife edge, these predators are highly vulnerable to stoichiometric imbalances, whether an excess or a deficit of nutrients is involved. Our results demonstrating this high sensitivity to prey C:P ratio show that the stoichiometric knife edge may apply not only to herbivores but also to higher trophic levels. Thus, predators such as P. sarsi, with a much narrower food quality range, may also be strongly affected by fluctuations in the quality of their prey, with negative consequences for their secondary production.","palabras_clave":"PREDATOR|FOOD QUALITY|GROWTH RATE|HOEMOSTASIS|PHOSPHORUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19329,"idioma_id":4,"titulo":"Macrophages and galectin 3 play critical roles in CVB3-induced murine acute myocarditis and chronic fibrosis","resumen":"Macrophage influx and galectin 3 production have been suggested as major   players driving acute inflammation and chronic fibrosis in many   diseases. However, their involvement in the pathogenesis of viral   myocarditis and subsequent cardiomyopathy are unknown. Our aim was to   characterise the role of macrophages and galectin 3 on survival,   clinical course, viral burden, acute pathology, and chronic fibrosis in   coxsackievirus B3 (CVB3)-induced myocarditis. Our results showed that   C3H\/HeJ mice infected with CVB3 and depleted of macrophages by   liposome-encapsulated clodronate treatment compared with infected   untreated mice presented higher viral titres but reduced acute   myocarditis and chronic fibrosis, compared with untreated infected mice.   Increased galectin 3 transcriptional and translational expression   levels correlated with CVB3 infection in macrophages and in non-depleted   mice. Disruption of the galectin 3 gene did not affect viral titres but   reduced acute myocarditis and chronic fibrosis compared with C57BL\/6J   wild-type mice. Similar results were observed after pharmacological   inhibition of galectin 3 with N-acetyl-d-lactosamine in C3H\/HeJ mice.   Our results showed a critical role of macrophages and their galectin 3   in controlling acute viral-induced cardiac injury and the subsequent   fibrosis. Moreover, the fact that pharmacological inhibition of galectin   3 induced similar results to macrophage depletion regarding the degree   of acute cardiac inflammation and chronic fibrosis opens up the   possibility of new pharmacological strategies for viral myocarditis.","palabras_clave":"CVB3|MYOCARDITIS|MACROPHAGES|GALECTIN-3"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19330,"idioma_id":4,"titulo":"Poly (I:C) downregulates platelet production and function through type I interferon","resumen":"Thrombocytopaenia is a frequent complication of viral infections; the underlying mechanisms appear to depend on the identity of the virus involved. Previous research, including reports from our group, indicates that as well as having antiviral activity type I interferons (IFN I) selectively downregulate platelet production. In this study we extended understanding of the role of endogenous IFN I in megakaryo\/thrombopoiesis by evaluating platelet and megakaryocyte physiology in mice treated with polyinosinic:polycytidylic acid [poly (I:C)], a synthetic analogue of double-stranded RNA, Toll-like receptor-3 ligand and strong IFN&#946; inducer. Mice-treated with poly (I:C) showed thrombocytopaenia, an increase in mean platelet volume and abnormal haemostatic and inflammatory platelet-mediated functionality, indicated by decreased fibrinogen binding and platelet adhesion, prolonged tail bleeding times and impaired P-Selectin externalisation, RANTES release and thrombin-induced platelet-neutrophil aggregate formation. These changes were associated with an increase in size and an abnormal distribution of bone marrow megakaryocytes within the vascular niche and were directly correlated with the plasmatic and bone marrow IFN&#946; levels. All these effects were absent in genetically modified mice lacking the IFN I receptor. Our results suggest that IFN I is the central mediator of poly (I:C)-induced thrombocytopaenia and platelet dysfunction and indicate that these abnormalities are due to changes in the last stages of megakaryocyte development. These data provide new evidence for the role of IFN I in megakaryocyte distribution in the bone marrow niches and its influence on thrombopoiesis and haemostasis.","palabras_clave":"INTERFERON|TROMBOCITOPENIA|PLAQUETAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19331,"idioma_id":4,"titulo":"Characterization of Metal\/Ceramic Interfaces in Dental Materials by Acoustic Emission","resumen":"Porcelain fused to metal (PFM) is one of the more extended combined rigid restoration devices used in dental materials. PFM  combines good mechanical properties of metals and aesthetic properties of ceramics. The quality of those parts depends on  metal\/ceramic interface, throughout factors like adhesion. There are different methods that evaluate the metal\/ceramic bond,  some of those are standardized. The aim of this work is to apply the Acoustic Emission technique (AE) in the characterization of  metal\/ceramic interfaces under the action of a charge. Elastic waves produced in any material when it is submitted to forces, are  known as AE. To assess the material behavior, the waves are detected by piezoelectric sensors. In this research, the  metal\/ceramic bond was studied by a flexural test of three points. The results of the AE parameters were correlated with surface  and heat treatment performed on the substrates. These changes affect metal-ceramic adhesion.","palabras_clave":"Acoustic Emission|Metal\/Ceramic Interface|Thermal treatments|Sanding Process"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19332,"idioma_id":5,"titulo":"Uso de la reacción en cadena de la polimerasa para el control terapéutico de la infección crónica por Trypanosoma  cruzi","resumen":"En las normas actuales de tratamiento etiológico de la fase crónica tardía de la enfermedad de Chagasen Argentina, Brasil y la Organización Mundial de la Salud, se recomienda controlar la eficaciaterapéutica con pruebas serológicas y parasitológicas convencionales. Sin embargo las primerassuelen continuar positivas 10 años o más luego del tratamiento, y las segundas son, en general, debaja sensibilidad en esta etapa de la enfermedad. La Reacción en Cadena de la Polimerasa (PCR)al ser más sensible que los exámenes parasitológicos convencionales, podría informar con unacobertura mayor si hubo falla terapéutica. Hemos ofrecido tratamiento con benznidazol (5 mg\/kg\/día, por 60 días) a 138 pacientes de 16 a 35 años de edad, infectados crónicamente con Trypanosomacruzi. La eficacia terapéutica se controló con PCR periódicas, hemocultivo y serología convencionalen dos grupos de pacientes: uno (GT, 57 pacientes) que aceptó y cumplió el tratamiento y otro(GNT, 37 pacientes) que lo rechazó. Antes de la administración de benznidazol la PCR mostró unasensibilidad diagnóstica de 41% (57\/138 pacientes) y el hemocultivo 7,2% (10\/138). Sesenta mesespostratamiento el grupo GT mostró una positividad de PCR acumulada de 28,1% (16\/57) y el grupoGNT 54,1% (20\/37; p=0.0016). A pesar de que la sensibilidad diagnóstica de PCR es limitada, lanegatividad de pruebas repetidas con método normatizado podría evidenciar disminución de laparasitemia o probable curación en 71,9% de los pacientes tratados, lo que habría que confirmar conel seguimiento serológico.","palabras_clave":"CHAGAS|PCR|BENZNIDAZOL|TRATAMIENTO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19333,"idioma_id":4,"titulo":"Ecology and genetic variation of Amblyomma tonelliae in Argentina","resumen":"The ecology of Amblyomma tonelliae (Ixodida: Ixodidae), including itsseasonal distribution and the development periods of each stage, was investigated duringa study carried out over two consecutive years in northwestern Argentina. In addition,the genetic variation of this tick was studied through analyses of 16S rDNA sequences.Amblyomma tonelliae has a 1-year lifecycle characterized by a long pre-moult periodin larvae with no development of morphogenetic diapause. Larvae peak in abundanceduring late autumn and early winter; nymphs peak in abundance in spring, and adults doso from late spring to early summer. Amblyomma tonelliae shows a marked ecologicalpreference for the driest areas of the Chaco ecoregion. In analyses of 16S rDNAsequences in genes from different populations of A. tonelliae, values for nucleotidediversity and the average number of nucleotide differences showed genetic diversitywithin this species to be low. No significant differences were found in comparisonsamong populations.","palabras_clave":"Amblyomma tonelliae|biology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19334,"idioma_id":4,"titulo":"Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells","resumen":"a b s t r a c tThe use of short chain fatty acids to modulate gastrointestinal inflammatory conditions such as ulcerativecolitis has produced encouraging results either in animal models or also in clinical trials. Identifyingthe key cellular and molecular targets of this activity will contribute to establish the appropriate combinations\/targeting strategies to maximize the efficacy of anti-inflammatory interventions. In the presentwork, we evaluated in vitro the interaction of lactate, acetate, propionate and butyrate on cells relevantfor innate immune response of the gastrointestinal tract. All molecules tested regulate the production ofproinflammatory cytokines by TLR-4 and TLR-5 activated intestinal epithelial cells in a dose responsemanner. Furthermore SCFAs and lactate modulate cytokine secretion of TLR-activated bone marrowderived macrophages and also TLR-dependent CD40 upregulation in bone marrow derived dendritic ina dose-dependent manner. Butyrate and propionate have been effective at concentrations of 1 to 5mMwhereas acetate and lactate produced modulatory effects at concentrations higher than 20?50mM indifferent assays. Our results indicate that in concentrations similar to found in large bowel lumen, allSCFAs tested and lactate can modulate activity of relevant sentinel cell types activated by TLR signals.Modulatory activity was not inhibited by pertussis toxin treatment indicating that the effects are notrelated to Gi signaling. The use of these molecules in combined or separately as intervention strategyin conditions where epithelial or myeloid cells are main triggers of the inflammatory situation seemsappropriate.© 2015 Elsevier GmbH. All rights reserved.","palabras_clave":"LACTATE|SHORT CHAIN FATTY ACIDS|MICROBIAL FEREMENTATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19335,"idioma_id":4,"titulo":"improved limit to the diffuse flux of ultra-high energy neutrinos from the Pierre Auger Observatory","resumen":"Neutrinos in the cosmic ray flux with energies near 1 EeV and above are detectable with the Surface Detector array (SD) of the Pierre Auger Observatory. We report here on searches through Auger data from 1 January 2004 until 20 June 2013. No neutrino candidates were found, yielding a limit to the diffuse flux of ultrahigh energy neutrinos that challenges the Waxman-Bahcall bound predictions. Neutrino identification is attempted using the broad time structure of the signals expected in the SD stations, and is efficiently done for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well asfor 'Earth-skimming' neutrino interactions in the case of tau neutrinos. In this paper the searches for downward-going neutrinos in the zenith angle bins 60°-75° and 75°-90° as well as for upward-going neutrinos, are combined to give a single limit. The 90% C.L. single-flavor limit to the diffuse flux of ultrahigh energy neutrinos with an E-2 spectrum in the energy range 1.0 × 1017 eV-2.5 × 1019 eV is E2&#957;dN&#957;=dE&#957; &lt; 6.4 × 10&#8722;9 GeV cm&#8722;2 s&#8722;1 sr&#8722;1.","palabras_clave":"Auger"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19336,"idioma_id":4,"titulo":"Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing","resumen":"Throughout the adult life of all mammals including humans, new neurons are incorporated in the dentate gyrus of the hippocampus. During a critical window that lasts about two weeks, adult-born immature neurons are more excitable and plastic than mature ones, and they respond to a wider range of inputs. In apparent contradiction, new neurons have been shown to be crucial to solve behavioral tasks that involve the discrimination of very similar situations, which would instead require high input specificity. We propose that immature neurons are initially unspecific because their task is to identify novel elements inside a high dimensional input space. With maturation, they would specialize to represent details of these novel inputs, favoring discrimination.","palabras_clave":"NEUROGENESIS|DENTATE GYRUS|PATTERN SEPARATION|HIPPOCAMPUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19337,"idioma_id":4,"titulo":"A new method for reconstructing the muon lateral distribution with an array of segmented counters","resumen":"Although the origin of ultra high energy cosmic rays is still unknown, significant progress has been achieved in last decades with the construction of large arrays that are currently taking data. One of the most important pieces of information comes from the chemical composition of primary particles. It is well known that the muon content of air showers generated by the interaction of cosmic rays with the atmosphere is rather sensitive to primary mass. Therefore, the measurement of the number of muons at ground level is an essential ingredient to infer the cosmic ray mass composition. In this work we present a new method for reconstructing the muon lateral distribution function with an array of segmented counters. The energy range from 4×1017eV to 2.5×1018eV is considered. For a triangular array spaced at 750&nbsp;m we found that 450&nbsp;m is the optimal distance to evaluate the number of muons. The corresponding statistical and systematic uncertainties of the new and of a previous reconstruction methods are compared. Since the statistical uncertainty of the new reconstruction is less than in the original one, the power to discriminate between heavy and light cosmic ray primaries is enhanced. The detector dynamic range is also extended in the new reconstruction, so events falling closer to a detector can be included in composition studies.","palabras_clave":"Ultra-high energy cosmic rays|Muon counters|Cosmic ray primary mass composition|Lateral distribution function"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19338,"idioma_id":4,"titulo":"NESTING BIOLOGY OF THE RED-CRESTED CARDINAL (PAROARIA CORONATA) IN SOUTH TEMPERATE FORESTS OF CENTRAL ARGENTINA","resumen":"Studies on breeding biology in Neotropical birds are crucial for understanding different aspects of their life histories and also for their conservation. We describe the nesting biology of the Red-crested Cardinal (Paroaria coronata) in central Argentina, a common suboscine that inhabits south temperate forests. We monitored 367 nests from October to February 2005?2008. Nest initiation followed a unimodal distribution with a peak in November. Within the forest, no nests were built on exotic tree species. Mean clutch size was 3.05 6 0.05 eggs and decreased with time within the breeding season; egg size did not vary across the breeding season. Nesting cycles lasted, on average, 25.8 6 0.1 days (nestconstruction: 6.1 6 0.4 days; incubation period: 11.9 6 0.1 days; nestling period: 13.8 6 0.1 days). At least one young fledged in 26% of nests, 62% were depredated, and 11% were abandoned. Egg survival rate was 0.95 6 0.02, hatchingsuccess rate was 0.84 6 0.02, and nestling survival rate was 0.81 6 0.03. Partial nestling losses were detected in 45% of the nests, of which 52% were because of brood reduction. Each breeding pair had on average 4.4 6 0.2 nesting attempts over the breeding season. Our results support the prediction that small clutch sizes are associated with extensive breeding seasons and several nesting attempts within a season. Except for the short incubation period, all other breeding features reported in this study differ from those of most north temperate birds and are consistent with the life history traits of Neotropical birds.","palabras_clave":"BREEDING SUCCESS|NESTING HABITAT|REPRODUCTIVE BIOLOGY|SOUTH TEMPERATE BIRDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19339,"idioma_id":4,"titulo":"Host switching in cowbird brood parasites: how often does it occur?","resumen":"Avian obligate brood parasites lay their eggs in nests of host species, which provide all parental care. Brood parasites may be host specialists, if they use one or a few host species, or host generalists, if they parasitize many hosts. Within the latter, strains of host-specific females might coexist. Although females preferentially parasitize one host, they may occasionally successfully parasitize the nest of another species. These host-switching events allow the colonization of new hosts and the expansion of brood parasites into new areas. In this study, we analyze host-switching in two parasitic cowbirds, the specialist screaming cowbird (Molothrus rufoaxillaris) and the generalist shiny cowbird (M. bonariensis) and compare the frequency of host-switches between these species with different parasitism strategies. Contrary to expected, host-switching did not occur more frequently in the generalist than in the specialist brood parasite. We also found that migration between hosts was asymmetrical in most cases and host-switches towards one host were more recurrent than backwards, thus differing among hosts within the same species. This might depend on a combination of factors including the rate at which females lay eggs in nests of alternative hosts, fledging success of the chicks in this new host and their subsequent success in parasitizing it.","palabras_clave":"Screaming cowbird|Shiny cowbird|Host switches|Genetic differentiation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19340,"idioma_id":4,"titulo":"Enhancement of tonic and phasic GABAergic currents following nitric oxide synthase inhibition in  hippocampal CA1 pyramidal neurons","resumen":"Nitric oxide (NO) is involved in synaptic plasticity in the hippocampus through different presynaptic and postsynaptic mechanisms that include the modulation of the GABAergic neurotransmission. Inhibitory synapses on hippocampal pyramidal neurons are known to possess the molecular machinery for retrograde NO-signaling, but the modulation of GABA A Rs function by NO in these neurons and the mechanisms of action involved have not been fully characterized. Here, we show that suppression of the endogenous NO generation by the nitric oxide synthase (NOS) inhibitor L-NAME produces significant and reversible increases in the magnitude of both tonic and phasic GABAergic currents in CA1 hippocampal pyramidal neurons. GABA-evoked chloride currents were measured in the presence or absence of L-NAME using whole-cell patch-clamp recordings in acute hippocampal slices from young adult mice. Enhancement of the tonic GABA responses induced by L-NAME was insensitive to TTX and decreased by co-incubation with the NO donor DEA\/NO. Applications of DEA\/NO alone did not produce significant effects on tonic GABA responses. L-NAME treatment also increased the amplitude of phasic GABAergic currents evoked by GABA-puffs. Our results indicate that the extent of tonic and phasic inhibition mediated by GABA A&nbsp; receptors in CA1 hippocampal pyramidal neurons is affected by endogenous NO production.&nbsp;","palabras_clave":"GABA RECEPTORS|NITRIC OXIDE|REDOX MODULATION|HIPPOCAMPUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19341,"idioma_id":4,"titulo":"Bioactive compounds as functional food ingredients: characterization in model system and sensory evaluation in chocolate milk","resumen":"The objective was the design and the structural and functional characterization of bioactive compounds  (BC) as functional food ingredients for a future industrial application in chocolate milk. Liposomes were  made of soy phosphatidylcholine, containing BC (omega-3, omega-6, vitamin E) and encapsulating folic  acid (FA). Stearic acid and calcium stearate were added as liposome stabilizers.  The oxidative stability, size and shape were analyzed by thiobarbituric acid method, light scattering,  and light microscopy, respectively. Membrane packing was also studied. Rheological behavior of liposomes  and encapsulation efficiency of FA were analyzed after pasteurization. Studies were performed  in food-model. Liposomes showed significant stability of all parameters and a protective effect over thermolabile  FA remaining half of this vitamin encapsulated.  Sensory evaluations were studied in chocolate milk with BC, demonstrating positive effects on acceptability.  For all the above, BC formulations are suitable for a future application and\/or scaling up in dairy  industry.","palabras_clave":"Liposomes|Bioactive Compounds|Vitamins|Folic Acid"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19342,"idioma_id":4,"titulo":"Molecular phylogenetic relationships of the lizard clade Liolaemus elongatus  (Iguania: Liolaemini) with the description of a new species from an isolated  volcanic peak in northern Patagonia","resumen":"A new species of the Andean-Patagonian Liolaemus elongatus clade is described. Liolaemus crandalli sp. nov. differs from other members of its clade by a combination of coloration characters, scale counts and genetic traits. Liolaemus crandalli sp. nov. is known only from an isolated volcanic mountain in northwestern Patagonia above 1500 m.a.s.l. unconnected with other habitat suitable for species of the Liolaemus elongatus clade.","palabras_clave":"Liolaemus crandalli|Nueva Especie|Auca Mahuida|Neuquen|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19343,"idioma_id":4,"titulo":"Model-based approach to test hard polytomies in the Eulaemus clade of the most diverse South American lizard genus Liolaemus (Liolaemini, Squamata)","resumen":"Lack of resolution in a phylogenetic tree is usually represented as a polytomy, and often adding more data (loci and taxa) resolves the species tree. These are the ?soft? polytomies, but in other cases additional data fail to resolve  relationships; these are the ?hard? polytomies. This latter case is often interpreted as a simultaneous radiation of lineages in the history of a clade. Although hard polytomies are difficult to address, model-based approaches provide new tools to test these hypotheses. Here, we used a clade of 144 species of the South American lizard clade Eulaemus to estimate phylogenies using a traditional concatenated matrix and three species tree methods: *BEAST, BEST,  and minimizing deep coalescences (MDC). The different species tree methods recovered largely discordant results, but all resolved the same polytomy (e.g. very short internodes amongst lineages and low nodal support in Bayesian  methods). We simulated data sets under eight explicit evolutionary models (including hard polytomies), tested these against empirical data (a total of 14 loci), and found support for two polytomies as the most plausible hypothesis  for diversification of this clade. We discuss the performance of these methods and their limitations under the challenging scenario of hard polytomies.","palabras_clave":"deep coalescences|incomplete lineage sorting|phylogeny|species trees"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19344,"idioma_id":4,"titulo":"Functional Characterization of Nupr1L, a novelp53-Regulated Isoform of the High Mobility Group (HMG)-Related Protumoral Protein Nupr1","resumen":"We have previously demonstrated a crucial role of NUPR1 in tumor development and progression. In this work we report the functional characterization of a novel Nupr1-like isoform (NUPR1L) and its functional interaction with the protumoral factor NUPR1. Through the use of primary sequence analysis, threading, and homology-based molecular modeling as well as expression and immunolocalization, studies reveal that NUPR1L displays properties which are similar to member of the HMG-like family of chromatin regulators including its ability to translocate to the cell nucleus and bind to DNA. Analysis of the NUPR1L promoter showed the presence of two p53-response elements at positions -37 and -7 respectively. Experiments using reporter assays combined with site-directed mutagenesis and using cells with controllable p53 expression demonstrate that both of these sequences are responsible for the regulation of NUPR1L expression by p53. Congruently, NUPR1L gene expression is activated in response to DNA damage induced by Oxaliplatin treatment or cell cycle arrest induced by serum starvation, two well-validated methods to achieve p53 activation. Interestingly, expression of NUPR1L down-regulates the expression of NUPR1, its closely related protumoral isoform, by a mechanism that involves the inhibition of its promoter activity. At the cellular level, overexpression of NUPR1L induces G1 cell cycle arrest and a decrease in their cell viability, an effect that is mediated, at least in part, by down-regulating NUPR1 expression. Combined these experiments constitute the first functional characterization of NUPR1L as a new p53-induced gene which negatively regulates the protumoral factor NUPR1. This article is protected by copyright. All rights reserved.","palabras_clave":"P53-DEPENDENT GENE|STRESS GENE|DNA DAMAGE|NUPR1L|NUPR1|P53"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19345,"idioma_id":4,"titulo":"TRAINING SPECIALISTS IN FORENSIC SOCIAL WORK AN EXPERIENCE OF CROSS-CULTURAL EDUCATION IN LATIN AMERICA","resumen":"This contribution analyzes relevant aspects of a cross-cultural teaching experience which included courses, conferences and institutional assessments, developed between 2012 and 2015, addressed to social workers working in the justice system. These events emerge as a result of the exchange between an innovative program of specialization in Forensic Social Work in the National University of Comahue (Argentina, 2010) -hereafter known as 'the Program'- the Judicial Council in Transition (Ecuador) and the National Institute of Forensic Sciences (Panamá).","palabras_clave":"FORENSIC SOCIAL WORK|CROSS-CULTURAL EDUCATION|LATIN AMERICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19346,"idioma_id":5,"titulo":"?Territorialidad y políticas públicas. El ámbito rural de La Matanza?.","resumen":"En este artículo pretendemos abordar las orientaciones desde las que se desarrollan las políticas de intervención para el desarrollo rural en el partido bonaerense de La Matanza, las estrategias de acción de los actores sociales participantes y el rol del Estado: cómo inciden las políticas públicas que se implementan en el área rural en los proyectos productivos y la sustentabilidad de dichas políticas desde lo económico, lo social y lo ambiental.Estasactividades productivas se desarrollan  en estrecha relación con las áreas urbanas, lo que permite encuadrarlas dentro del concepto de agricultura periurbana, entendida ésta como un ?territorio de producción alimentaria de proximidad?. El estudio de la temática rural en La Matanza no posee mucha tradición, a pesar de que las áreas rurales ocupan un tercio de la superficie del distrito. Las producciones que allí se asientan son el resultado, en su mayor parte, de esfuerzos e iniciativas privadas o de organizaciones sociales. Las políticas públicas locales han abordado de manera insuficiente al sector, de modo que no resulta posible ponderar con exactitud la contribución actual o potencial del mismo a la economía del distrito. Considerando la agricultura familiar como actor significativo en la agricultura periurbana del Territorio Periurbano Oeste del Area Metropolitana de Buenos Aires, enfatizaremos el análisis de las políticas para este tipo particular de actividad. Pretendemos aportar herramientas para pensar en una concepción integral de las políticas públicas para el sector productivo local, en el que la producción agropecuaria posee incidencia actual y potencial.","palabras_clave":"TERRITORIALIDAD |POLITICAS|RURAL |ESTADO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19347,"idioma_id":4,"titulo":"Effects on the martensitic transformations and the microstructure of CuAlNi single crystals after ageing at 473 K","resumen":"Isothermal treatments at 473 K were performed in CuAlNi single crystals to study their effects on the main properties of this shape memory material. Both the stress and thermally induced martensitic transformations were monitored after these ageing treatments. An increase of the critical transformation temperature was detected and the type of induced martensite changed from &#947;&#8242; into &#946;&#8242; after a long enough ageing time. Pseudoelastic cycling was studied after thermal ageing; mechanical behaviour evolved on cycling and a repetitive behaviour was obtained after a small number of cycles. Changes in microstructure were analysed in the &#946; phase by transmission electron microscopy which allowed observing the morphology and distribution of &#947; precipitates. The changes obtained in shape memory properties were discussed considering the atomic ordering evolution and characteristics of the precipitates.","palabras_clave":"SHAPE MEMORY|PRECIPITATION|DISLOCATIONS|MECHANICAL PROPERTIES|TRANSMISSION ELECTRON MICROSCOPY, TEM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19348,"idioma_id":4,"titulo":"Important sources of variation to be considered when using fin clips as a surrogate for muscle in trophic studies using stable isotopes","resumen":"White muscle is the prevalent tissue for C and N stable isotope analysis in fish, requiring the death of the fish or biopsy procedures that could led to infections or severe damage. Given that caudal fin-clipping does not seriously affect growth or condition, the present study assessed the suitability of caudal fin as muscle replacement in trophic studies. Caudal fin clips of caudal fin were a useful non-lethal  surrogate of muscle samples in four studied reef-fish (Silver porgy, Diplodus argenteus,; Red porgy, Pagrus pagrus,; Argentinean sea bass, Acanthistius patachonicus and Brazilian sandperch Pinguipes brasilianus). Fin clips were easy to collect in quantities adequate to mass spectrometry analyses and had C:N ratios similar to white muscle with low lipid content. However, results showed that fin-muscle correction models should be specific and sampling should be conducted reducing spatial and temporal variation. Moreover, species-specific correction factors may not be valid to other populations of the same species if the presumably range of deltaX values differ from the population used to estimate the correction models.Thus, correction models could be applied for different populations and\/or times only if deltaX values of the studied population presumably ranged within similar boundaries than the population used to estimate correction factors.  Results also showed that fin-muscle relationship could vary with size. Thus, unless a non-ecological meaningful fin-muscle correlation with body size was previously identified, correction models should be estimated sampling a representative size range and fin samples should be used with caution to study size-related trophodynamic.","palabras_clave":"CARBON|NITROGEN|ISOTOPES|TROPHODYNAMIC|TROPHIC ECOLOGY|MARINE FISH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19349,"idioma_id":4,"titulo":"Marine pollution effects on the southern surf crab Ovalipes trimaculatus (Crustacea: Brachyura: Polybiidae) in Patagonia Argentina","resumen":"We compared the carapace shape and thickness as well as the energy density of Ovalipes trimaculatus  inhabiting areas comprising a gradient of marine pollution: high, moderate and undetected, in the Nuevo  gulf (Patagonia Argentina). The carapace shape was evaluated by means of individual asymmetry scores  (=fluctuating asymmetry) whereas the carapace thickness was assessed by measuring the carapace dry  weight. The energy density was analyzed through its negative relationship with water content in muscle  tissue. The individual asymmetry scores as well as the percentage of water content in muscle tissue were  proportional to the marine pollution gradient, whereas the carapaces thickness did not differ among sampling  sites. Our results are consistent with previous findings and demonstrate the direct effect of marine  pollution on other taxa different from gastropods, cephalopods and polyplacophora and add to longstanding  concerns about detrimental effects caused by marine pollution on the benthic community of  the Nuevo gulf.","palabras_clave":"SWIMMING CRAB|FLUCTUATING ASIMMETRY|CARAPACE SHAPE|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19350,"idioma_id":5,"titulo":"Vida en los fondos profundos del mar","resumen":"El estudio de la vida en el mar se hace cada vez más difícil a medida que las aguas investigadas se alejan de la costa y se encuentran a profundidades crecientes. Al mismo tiempo, los frutos de la investigación resultan crecientemente valiosos, pues esas mismas dificultades los han hecho muy escasos. El uso del buque oceanográfico Puerto Deseado, perteneciente al Conicet, en tres campañas realizadas en los últimos cinco años, permitió que los biólogos marinos dieran un paso adelante en el conocimiento de la vida en el Atlántico a más de 1km de profundidad.","palabras_clave":"PROFUNDIDAD|EQUINODERMOS|CNIDARIOS|B\/O PUERTO DESEADO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19351,"idioma_id":4,"titulo":"DEFORMED MICROBIAL MAT STRUCTURES IN A SEMIARID TEMPERATE COASTAL SETTING","resumen":"This study focuses of sedimentary structures formed by microbial consortia, in a particular coastal setting, an ancient tidal channel, separated from the ocean by a sandy spit and connected by a blind tidal channel at the opposite end. Most studies in modern and ancient environments consider water movement as the triggering mechanism acting in the formation and deformation of sedimentary structures. As such, the paper documents the presence of several microbial structures such as shrinkage cracks, flip-over mats, microbial chips and multidirectional ripples which are related to tidal processes, while bulges and gas domes structures are formed after occasional inundation events. However, the more conspicuous structures covering a great area at the study site are folds and roll-ups, the product of deformation of microbially-induced structures by the action of sporadic spring-tidal currents due to strong winds. Therefore, the objective of this research is to document modern sedimentary structures in a coastal area and to provide a mechanistic explanation for their formation, based on the interplaying effects of the moisture variation and high shear-stress. Also, several microbial sedimentary structures are distinguished throughout vertical sediment cores, such as microbial chips, detached mat, sponge fabrics, tears and concentric structures, which are identified in a sedimentary profile. Through the recognition and interpretation of modern sedimentary deformation structures, this study contributes empirical tools for the reconstruction of analogous paleoenvironments in fossil studies.","palabras_clave":"ROLL-UP MICROBIAL STRUCTURES|FOLD MICROBIAL STRUCTURES|FILAMENTOUS CYANOBACTERIA|TIDAL CURRENTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19352,"idioma_id":4,"titulo":"PREDATION ON RECENT MARINE AND FRESH-WATER  OSTRACOD POPULATIONS OF THE CENTRAL REGION OF  THE REPUBLIC ARGENTINA","resumen":"The presence of evidence of depredation in ostracods valves from marine and freshwater environments of the central region of the republic Argentina are studied in this paper. In samples from intertidal environment (Puerto Rosales) a total of 800 shells of ostracods were recovered of which only 0.50% (4 valves) presented evidence of predation. In freshwater environments (Laguna Don Tomás) a total of 1447 valves were recovered of which only 1.10% (16 valves) presented evidence of predation. Two types of depredation fossil traces were determined: Oichnus simplex Bromley and Oichnus paraboloides Bromley. Oichnus simplex Bromley predominate over drilling Oichnus paraboloids Bromley attributed to predatory gastropods activity, both marine and continental environments. There was not relationship between the borehole diameter and the size of the predated valves. The ornamentation of the valves is not a character that conditions predation, since the species predated have different type of ornamentation from thin ribs to crosslinks with very prominent ribs.","palabras_clave":"Ostracodes|Predation|Puerto Rosales|Santa Rosa"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19353,"idioma_id":4,"titulo":"Nebular phase observations of the type-Ib supernova iPTF13bvn favour a binary progenitor","resumen":"Aims. We present and analyse late-time observations of the type-Ib supernova with possible pre-supernova progenitor detection, iPTF13bvn, taken at $\\sim$300 days after the explosion, and discuss these in the context of constraints on the supernova's progenitor. Previous studies have proposed two possible natures for the progenitor of the supernova, i.e. a massive Wolf-Rayet star or a lower-mass star in close binary system. Methods. Our observations show that the supernova has entered the nebular phase, with the spectrum dominated by Mg~I]$\\lambda\\lambda$4571, [O~I]$\\lambda\\lambda$6300, 6364, and [Ca~II]$\\lambda\\lambda$7291, 7324 emission lines. We measured the emission line fluxes to estimate the core oxygen mass and compare the [O~I]\/[Ca~II] line ratio with other supernovae. Results. The core oxygen mass of the supernova progenitor was estimated to be $\\lesssim$0.7 M$_\\odot$, which implies initial progenitor mass not exceeding $\\sim$15 -- 17 M$_\\odot$. Since the derived mass is too small for a single star to become a Wolf-Rayet star, this result lends more support to the binary nature of the progenitor star of iPTF13bvn. The comparison of [O~I]\/[Ca~II] line ratio with other supernovae also shows that iPTF13bvn appears to be in close association with the lower-mass progenitors of stripped-envelope and type-II supernovae.","palabras_clave":"SUPERNOVAE: GENERAL|SUPERNOVAE: INDIVIDUAL: IPTF13BVN|STARS: MASSIVE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19354,"idioma_id":4,"titulo":"Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage","resumen":"The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging process may operate in the hippocampus late after acquisition for the persistence of long-lasting memory storage. The proposed maintenance tagging has several characteristics: (1) the tag is transient and time-dependent; (2) it sets in a late critical time window after an aversive training which induces a short-lasting LTM; (3) exposing rats to a novel environment specifically within this tag time window enables the consolidation to a long-lasting LTM; (4) a familiar environment exploration was not effective; (5) the effect of novelty on the promotion of memory persistence requires dopamine D1\/D5 receptors and Arc expression in the dorsal hippocampus. The present results can be explained by a broader version of the behavioral tagging hypothesis and highlight the idea that the durability of a memory trace depends either on late tag mechanisms induced by a training session or on events experienced close in time to this tag.","palabras_clave":"hippocampus|maintenance tag|novelty|memory persistence|rats"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19355,"idioma_id":4,"titulo":"Stable isotope analysis of trophic structure, energy flow and spatial variability in a large ultraoligotrophic lake in Northwest Patagonia","resumen":"The foodweb structure of the largest lake in northwest Patagonia, Lake Nahuel Huapi (area 557 km2),was investigated. Fish, benthic macroinvertebrates, plankton and primary producers were analyzed for stable nitrogen(&#948;15N) and carbon (&#948;13C) isotopes in three sites with contrasting morphometry and environmental characteristics.&#948;15N and &#948;13C revealed a similar food web structure between basins but with distinct isotopic baselines. The SIAR (Stable Isotope Analysis in R) mixingmodelwas used to study potential food sources (benthic or pelagic) for adult fish. Results indicated that energy flow to fish from both habitats is different for each site and species, and does not depend on the basin morphometry. An ontogenetic shift in the carbon source and trophic level was observed in some of the fish species, revealing a  oupling between the pelagic and bentho-littoral habitats of thelake. Our findings complement the existing literature on trophic interactions between introduced and native fish, and provide novel information on plankton composition, food web structure and energy flow in a large lake of North Patagonia that can be extrapolated to other understudied lakes in the area.","palabras_clave":"Stable isotope analysis   |Patagonia|Mixing model|Trophic relationships"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19356,"idioma_id":5,"titulo":"Lukács y Los años de aprendizaje de Wilhelm Meister","resumen":"La lectura que György Lukács hace de la novela de formación Los años de aprendizaje de Wilhelm Meister (1795\/96) en Teoría de la novela (1914\/5; publ. como libro en 1920), ?La novela [como epopeya burguesa]? (1935) y Goethe y su época (1936; publ. 1947) puede ser entendida como respuesta a dos planteos anteriores acerca de la misma: de G. W. F. Hegel (Estética, de 1818-1829, aunque publicada recién en 1835-1838) y Wilhelm Dilthey (Vida y poesía, de 1906), concretamente. Esta respuesta está basada en una interpretación ?con matices específicos en cada caso? de la goetheana ?Sociedad de la Torre?,  motivo literario en el cual el autor de El alma y las formas ve, por un lado, la representación de la posibilidad de una relación no alienada entre los hombres al interior de la sociedad capitalista-burguesa (en esto se funda el distanciamiento crítico tanto de Hegel como de Dilthey) y, por otro y por esto mismo, las limitaciones propias del clasicismo alemán.","palabras_clave":"Renuncia|Realismo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19357,"idioma_id":4,"titulo":"Antifungal starter culture for packed bread: influence of two storage conditions","resumen":"Abstract In this study, we analyzed the conservation of a semi-liquid bio-preserver (SL778) developed with Lactobacillus plantarum CRL 778, a lactic acid bacterium (LAB) having antifungal activity. The characteristics of the SL778 starter remained stable during a 14-day storage at 4 &#9702;C. At &#8722;20 &#9702;C, cell viability and organic acid concentration showed a significant (p < 0.05) decrease after 7 days. These differences observed between the storage temperatures tested were reflected in the acidification activity of SL778 during dough fermentation. However,SL778 maintained its antifungal efficacy up to a 14-day storage at both temperatures. Sensory attributes (acidic and spicy tastes and acidic smell) of breads manufactured with starter SL778 (stored at 4 or &#8722;20 &#9702;C) were evaluated. No undesirable difference was detected with respect to bread control without SL778 and bread manufactured with SL778 (stored at 4 or &#8722;20 &#9702;C). In conclusion, the SL778 semi-liquid bio-preserver can be stored at 4 or &#8722;20 &#9702;C without modifying its antifungal activity during 14 days.","palabras_clave":"Bacterias làcticas|panificados |cultivos iniciadores|bioconservación"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19358,"idioma_id":4,"titulo":"Removal of pathogenic bacterial biofilms by combinations of oxidizing compounds","resumen":"Bacterial  biofilms are commonly formed on medical devices and food processing surfaces. As  antimicrobials used have limited efficacy against them, new strategies to  prevent and to remove these structures are needed. Here, the effectiveness of  brief oxidative treatments, based on the combination of NaClO and H2O2  in the presence of CuSO4, were evaluated against bacterial laboratory strains and clinical isolates,  both in planktonic and biofilm state. Simultaneous application of oxidants  synergistically inactivated planktonic cells and prevented biofilm formation of laboratory Escherichia  coli, Salmonella Typhimurium, Klebsiella pneumoniae, and Staphylococcus  aureus strains, and clinical isolates of S. enterica, K. oxytoca  and uropathogenic E. coli. In  addition, preformed biofilms of E. coli C, S. Typhimurium, K. pneumoniae and S. enterica exposed to treatments were removed  applying 12 mg\/L NaClO, 0.1 mmol\/L CuSO4 and 350 mmol\/L H2O2,  for 5 min. K. oxytoca and S. aureus  required a five-fold increase in NaClO concentration and the E. coli clinical isolate remained  irremovable unless treatments were applied on biofilms formed during 24 h  instead of 48 h. The application of treatments that last a few minutes using oxidizing  compounds at low concentrations represents an interesting disinfection strategy  against pathogens associated with medical and industrial settings.","palabras_clave":"biofilm|oxidative treatment |disinfection|pathogens"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19359,"idioma_id":4,"titulo":"Improvement in imazalil treatments in commercial packinglines to control green mold on lemon fruit","resumen":"    Long distance to markets limits global competitiveness in lemon fruit production due to fungal postharvest decays, such as green mold caused by Penicillium digitatum. Imazalil, the main fungicide used, is formulated as an emulsifiable concentrate (IEC) and as a water-soluble sulphate salt (IS), the later being less commonly applied in most of the producing countries. The aim of the present report was to improve the effectiveness of imazalil treatments to control green mold in commercial scale. In both laboratory and commercial applications, IS was more effective than IEC. IS formulation applied in water followed by IEC applied in wax is an improved option that provided suitable disease control and optimal residue loading &gt;2.0&nbsp;mg&nbsp;L&#8722;1 without exceeding the maximum residue levels. Additionally, IMZ residues remained at acceptable levels after 28 days at 7&nbsp;°C, assuring the protection of lemon fruit for long periods of storage and transports.","palabras_clave":"citrus|Penicillium digitatum|imazalil| postharvest"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19360,"idioma_id":4,"titulo":"Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures","resumen":"In this study, ultrasound-assisted extraction (UAE) was evaluated as an easier and more efficientalternative method for the isolation of anthraquinones (AQs) from Heterophyllaea pustulata Hook f.(Rubiaceae), compared with conventional extraction techniques. The extraction was performed usingan ethanol?water solution as solvent. The influence of different operating conditions, as temperature,time, solvent composition, and solvent\/sample ratio and its relationship with ultrasonic techniques wasanalyzed. For this purpose and to achieve global optimization of the ultrasound-assisted extraction of H.pustulata, Taguchi experimental design with a L9 orthogonal array was applied.The results showed that the yield obtained with the ultrasound assisted extraction is approximatelytwice higher than the traditional Soxhlet technique, and Taguchi analysis demonstrated that the mostinfluential factor is solvent concentration, followed by time, temperature, and solvent\/sample ratio. Thesolvent composition effect is directly related to cavitation process, and the effect of solvent physicalproperties on it. The optimal combination of these factors on the ultrasound assisted extraction is asolvent composition 60% v\/v of ethanol, a solvent\/sample ratio equal to 20:1, a temperature of 55&#9702;C, andan extraction time of 30 min.","palabras_clave":"Ultrasound-Assisted Extraction|Anthraquinone|Optimization|Taguchi experimental design"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19361,"idioma_id":4,"titulo":"Pressurized hot water extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae)","resumen":"tHeterophyllaea Pustulata Hook. f. (Rubiaceae), commonly known as ?cegadera?, is a phototoxic native plantfrom South America, containing anthraquinones with important antibacterial, antiviral and anticanceractivity. In this work, pressurized hot water extraction (PHWE) was applied to extract anthraquinonesfrom the stems of the plant. The effect of temperature, pressure and water flow rate on the extractionyield of four anthraquinones (soranjidiol, rubiadin, rubiadin 1-methyl ether and 2-hydroxy-3-methylanthraquinone) was studied. Within the experimental range explored, the optimum extraction temper-ature was 170&#9702;C. Lower yields were obtained at higher temperatures, apparently due to the thermaldecomposition of these anthraquinones. The experimental extraction curves were fitted with threemodels: the thermodynamic partitioning and the one-site and two-site kinetic models.","palabras_clave":"HETEROPHYLLAEA PUSTULATA|ANTHRAQUINONES|PRESSURIZED HOT WATER EXTRACTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19362,"idioma_id":4,"titulo":"Evaluation of the antibacterial effects of vancomycin hydrochloride released from agar-gelatin-bioactive glass composites","resumen":"The aim of this work was to evaluate the perfomance  of agar-gelatin (AG) composites and AG containing 45S5 bioactive glass (BG)  microparticles (AGBG) in relation to their water uptake capacity, sustained release of a drug over time, and  antibacterial effects. The composites were fabricated by the gel-casting method. To impart the  local drug release capacity, vancomycin hydrochloride (VC) was loaded in the composites in  concentrations of 0.5 and 1 mg ml&#8722;1. VC release was assessed in distilled water at 37 °C up  to 72 h and quantified spectrophotometrically. The antibacterial activity of composites was  evaluated by the inhibition zone test and the plate count method. The experiments were performed in  vitro up to 48 h on three staphylococcus strains:Staphylococcus aureus ATCC29213,S. aureus ATCC6538  and Staphylococcus epidermidis ATCC12228. The results showed that the  addition of BG to AG composites did not affect the degree of wáter uptake. The  release of VC was significantly affected by the presence of BG. VC release was  higher from AGBGVC films than from AGVC ones over prolonged incubation times.  Bacterial inhibition zones were found around the composites. The halos were  larger when the cells were put in contact with AGVC composites than when they  were put in contact with AGBGVC ones. Nevertheless, the viable count method  demonstrated that the composites inhibited Staphylococcus cell growth with no  statistical differences. In conclusion, the addition of BG did not reflect an  improvement in the parameters studied. On the other hand, composites loaded  with VC would have a role in prophylaxis against bacterial infection.","palabras_clave":"BIOPOLYMERS|BIOACTIVE GLASS|VANCOMYCIN|STAPHYLOCOCCI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19363,"idioma_id":4,"titulo":"Bacillus subtilis subsp. subtilis CBMDC3f with antimicrobial activity against Gram-positive foodborne pathogenic bacteria. UV-MALDI-TOF MS analysis of its bioactive compounds","resumen":"In this work a new Bacillus sp. strain, isolated from honey, was characterized phylogenetically. Its antibacterial activity against three relevant foodborne pathogenic bacteria was studied; the main bioactive metabolites were analyzed using ultraviolet matrix assisted laser desorption-ionization mass spectrometry (UV?MALDI MS). Bacillus CBMDC3f was phylogenetically characterized as Bacillus subtilis subsp. subtilis after rRNA analysis of the 16S subunit and the gyrA gene (access codes Genbank JX120508 and JX120516, respectively). Its antibacterial potential was evaluated against Listeria monocytogenes (9 strains), B. cereus (3 strains) and Staphylococcus aureus ATCC29213. Its cell suspension and cell-free supernatant (CFS) exerted significant anti-Listeria and anti-S. aureus activities, while the lipopeptides fraction (LF) also showed anti-B. cereus effect. The UV-MALDI-MS analysis revealed surfactin, iturin and fengycin in the CFS, whereas surfactin predominated in the LF. The CFS from CBMDC3f contained surfactin, iturin and fengycin with four, two and four homologues per family, respectively, whereas four surfactin, one iturin and one fengycin homologues were identified in the LF. For some surfactin homologues, their UV-MALDI-TOF\/TOF (MS\/MS; Laser Induced Decomposition method, LID) spectra were also obtained. Mass spectrometry analysis contributed with relevant information about the type of lipopeptides that Bacillus strains can synthesize. From our results, surfactin would be the main metabolite responsible for the antibacterial effect.","palabras_clave":"Bacillus subtilis subsp. subtilis|FOODBORNE PATHOGENS|LIPOPEPTIDE HOMOLOGUES|UV-MALDI-TOF MS|SURFACTIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19364,"idioma_id":4,"titulo":"Activated carbon-modified knotted reactor coupled to electrothermal atomic absorption spectrometry for sensitive determination of arsenic species in medicinal herbs and tea infusions","resumen":"A flow injection system based on a modified polytetrafluoroethylene (PTFE) knotted reactor (KR) was developed for arsenite [As(III)] and arsenate [As(V)] species preconcentration and determination by electrothermal atomic absorption spectrometry (ETAAS). Activated carbon (AC) was immobilized on the inner walls of a PTFE KR by a  thermal treatment. A significant increase in analyte retention was obtained with the AC-modified KR (100%) as compared to the regular PTFE KR (25%). The preconcentration method involved the on-line formation of  As(III)-ammonium pyrrolidinedithiocarbamate (As-APDC) complex, followed by its adsorption onto the inner walls of the AC-modified KR. After analyte retention, the complex was eluted with acetone directly into the  graphite furnace of ETAAS. The parameters affecting the flow injection system were evaluated with a full central composite face centered design with three center points. Under optimum conditions, a preconcentration factor of 200 was obtained with 10 ml of sample. The detection limit was 4 ng L&#8722;1 and the relative standard deviation (RSD) for six replicate measurements at 0.2 &#956;g L&#8722;1 of As were 4.3% and 4.7% for As(III) and As(V), respectively. The developed methodology was highly selective towards As(III), while As(V), monomethylarsonic acid  [MMA(V)] and dimethylarsinic [DMA(V)] were not retained in the AC-modified KR. The proposed method was   successfully applied for As speciation analysis in infusions originated from medicinal herbs and tea.","palabras_clave":"Knotted reactor|Asenic speciation|Medicinal Herb|Tea|ETAAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19365,"idioma_id":4,"titulo":"Ionic liquid-assisted multiwalled carbon nanotube-dispersive micro-solid phase extraction for sensitive determination of inorganic As species in garlic samples by electrothermal atomic absorption spectrometry","resumen":"A highly sensitive dispersive micro-solid phase extraction (D-&#956;-SPE) method combining an ionic liquid (IL) and multi-walled carbon nanotubes (MWCNTs) for inorganic As species (As(III) and As(V)) species separation and determination in garlic samples by electrothermal atomic absorption spectrometry (ETAAS) was developed. Trihexyl(tetradecil)phosphonium chloride IL was used to form an ion pair with the arsenomolybdate complexobtained by reaction of As(V) with molybdate ion. Afterwards, 1.0 mg of MWCNTs was dispersed for As(V) extraction and the supernatant was separated by centrifugation. MWCNTs were re-dispersed withtetradecyltrimethylammoniumbromide surfactant and ultrasound followed by direct injection into the graphite furnace of ETAAS for As determination. Pyrolysis and atomization conditionswere carefully studied for completedecomposition of MWCNTs and IL matrices. Under optimum conditions, an extraction efficiency of 100% and a preconcentration factor of 70 were obtained with 5 mL of garlic extract. The detection limit was 7.1 ng L&#8722;1and the relative standard deviations (RSDs) for six replicate measurements at 5 &#956;g L&#8722;1 of As were 5.4% and 4.8% for As(III) and As(V), respectively. The proposed D-&#956;-SPE method allowed the efficient separation and determination of inorganic As species in a complex matrix such as garlic extract.","palabras_clave":"ARSENIC|MULTI-WALLED CARBON NANOTUBES|DISPERSIVE MICRO-SOLID PHASE EXTRACTION|GARLIC"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19366,"idioma_id":5,"titulo":"LA PRODUCCIÓN TECNOLÓGICA EN LA ARQUITECTURA  SUSTENTABLE. ANÁLISIS CRÍTICO DE LOS ENFOQUES VIGENTES","resumen":"En el presente artículo se examinan los presupuestos que guían la producción tecnológica en el campo de la Arquitectura Sustentable. Se recuperan conceptos y teorías del campo de estudio de Ciencia, Tecnología y Sociedad (CTS) que permiten ampliar la concepción instrumentalista de la Tecnología, tanto hacia el reconocimiento de los elementos que intervienen en su proceso, como del modelo de desarrollo que orienta dicha práctica. El estudio se delimita a las ponencias presentadas en los ámbitos de discusión de la Asociación Argentina de Energías Renovables y Ambiente (ASADES), desde el 2006. El análisis permitió reconocer la co-existencia de tres enfoques en el sector, cada uno con presupuestos epistemológicos y metodológicos particulares, que se traducen en procesos y productos tecnológicos diferentes.","palabras_clave":"Producción de Tecnología|Arquitectura Sustentable|ASADES|CTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19367,"idioma_id":4,"titulo":"Molecular cytogenetic insights into the evolution of the epiphytic genus Lepismium (Cactaceae) and related genera","resumen":"Changes in chromosome structure and number play an important role in plant evolution. This was investigated in the Neotropical epiphytic cacti: all Lepismium spp. and some related Rhipsalis spp. Both genera have species with disjunct distributions between the paranas of south-eastern Brazil and north-eastern Argentina and the yungas forests of the eastern Andes. Karyotypes, fluorescent banding and fluorescence in situ hybridization (FISH) studies using rDNA probes were performed. A time-calibrated phylogenetic tree was generated to place the karyological information and biogeographical history in an explicit evolutionary context. All species were 2n = 22 and showed symmetrical karyotypes comprising only metacentric chromosomes of similar sizes. The heterochromatin bands were always associated with chromosome satellites coinciding with the location and number of the 18S?5.8S?26S rDNA loci. The 5S rDNA loci had more heterogeneous profiles with one or two loci per haploid genome.  Phylogenetic analysis suggested an ancient duplication event of the 5S rDNA loci and more recent post-speciation translocation and deletion events. These genome restructurings are estimated to have occurred approximately 13.98 Mya in the middle Miocene, after Lepismium and Rhipsalis diverged. The ancestor of Lepismium may have  had a similar karyotype to L. lumbricoides and the Rhipsalis spp. (i.e. one 5S locus on chromosome 2). Both genera hypothetically originated in the yungas (north-eastern Argentina and southern Bolivia), but diversification of the Lepismium crown group probably originated from populations with duplicated 5S loci in the parana forests of south-eastern Brazil (8.70 Mya in the late Miocene). Two migration events between the yungas and parana forests were suggested to explain the extant distribution of Lepismium spp.","palabras_clave":"CACTACEAE|DNA RIBOSOMICO|HETEROCROMATINA|FILOGENIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19368,"idioma_id":4,"titulo":"Stratigraphy and sedimentology of the terminal fan of Candeleros Formation (Neuquen Group), Lower Cretaceous, Neuquen basin, provinces of Neuquen and Mendoza, Argentina","resumen":"The Candeleros Formation is represented by a succession of deposits that represent terminal fans  starting to fill a foreland basin (back-arc) during the Albian. The different sub-environments of the  terminal fan suggest low gradients during the onset of deposition of the Río Limay Subgroup (Neuquén  Group). The terminal fan system is represented by distributary zone (TF-DZ), distributary zone - base  zone (TF-DZBZ) and base zone deposits (TF-BZ). Its most notable feature is the presence of bitumen  in 'pockets' and scattered in the sandstone channel fill and crevasse splays deposit.  In this system the feeder zone of the terminal fan system has not been identified, however, the  distribution of architectural elements and paleocurrent data allow us to infer that the catchment area of  the backbone would have been located to the NNW\/NW.  Distributary zone deposits of the are characterized by thick deposits of low sinuosity channel, with a  high degree of connectivity and strong vertical aggradation of channel belts.  Deposits of distributary zone - base zone are characterized by a higher density of channel deposits \/  distributary plain, but with belt channel less thick, longer laterally, greater width\/thickness ratio and  connectivity in the braided deposits.  The distal parts of the terminal fan are well represented and vary only in the channelized deposits and  mantle\/floodplain ratio, which is abruptly reduced towards the flood basin connection.  The importance of Candeleros Formation deposits is that they are remnants of accommodation that  preserved the original architecture and represent exhumed reservoirs.","palabras_clave":"Candeleros Formation| Neuquen Basin| terminal fan"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19369,"idioma_id":4,"titulo":"Phenotypic diversity in female body shape is related to reproductive potential in Tupinambis merianae lizards","resumen":"In this work we aim to shed light on the microevolutionary mechanisms underlying female morphology diversity to elucidate the role of sexual selection on the phenotypic variance of sexual traits. Since Tupinambis merianae is a male biased size-dimorphic species we aim to explore the magnitude of variation of several female body traits to evaluate if sexual selection is influencing phenotypic traits, other than SVL, to increment fitness. To explore the diversity of available morphs in mature female lizards, its relationship with fitness? measures, and its association with behavioral patterns will allow a better understanding of the diversity of female mating strategies to discuss the evolutionary dynamics of the female body shape in the context of sexual selection.","palabras_clave":"LIZARDS|TUPINAMBIS|BODY SHAPE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19370,"idioma_id":4,"titulo":"Textural and Chemical Changes during Ripening of Port Salut Argentino Light Cheese with Milk Protein Concentrate after Long Frozen Storage Period","resumen":"Texture of a Port Salut Argentino light cheese with milk protein concentrate after 5 months of frozen storage was studied. Behavior of dynamic rheological measurements during ripening time (6, 20, 33, 47 and 68 days) with maturation index was analyzed. At 68 days of ripening, moisture decreased by 11% and total nitrogen content increased by 25% in frozen cheeses with respect to control cheeses. Between 6 and 68 days of ripening, maturation index was higher for frozen (17.8?29.1) than control cheeses (4.4?11.6). G&#8242; was higher than G&#8243; showing that elastic behavior was dominant. During ripening, these parameters decreased in control cheeses, but increased in frozen cheeses. According to power law model parameters, elastic properties were more sensitive to changes with frequency. Coefficient a was significantly affected for both freezing process and ripening time, coefficient b only by freezing process. Long frozen storage period affected significantly the physicochemical and textural characteristics.","palabras_clave":"PORT SALUT ARGENTINO LIGHT CHEESE|TEXTURE CHANGES WITH RIPENING|FROZEN STORAGE|RHEOLOGICAL BEHAVIOR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19371,"idioma_id":4,"titulo":"Absolute Determination of the Gelling Point of Gelatin under Quasi-thermodynamic Equilibrium","resumen":"P { margin-bottom: 0.21cm; }        Thermodynamic studies on phase  transformation of biopolymers in solution are   useful to understand  their nature and to evaluate their technological potentials.  Thermodynamic studies should be conducted avoiding time-related  phenomena. This condition is not easily achieved in hydrophilic  biopolymers. In this contribution, the simultaneous effects   of pH,  salt concentration, and cooling rate (Cr) on the folding from random  coil to triple helical   collagen-like structures of gelatin were  systematically studied. The phase transformation   temperature at the  absolute invariant condition of Cr = 0 °C\/min (TTCr=0)  is introduced as a   conceptual parameter to study phase  transformations in biopolymers under quasi-  thermodynamic equilibrium  and avoiding interferences coming from time-related phenomena.  Experimental phase diagrams obtained at different Cr are presented.  The TT  Cr=0 vs. pH and TTCr=0  vs. [NaCl] diagram allowed to explore the transformation process at  Cr = 0 °C\/min. The results were explained by electrostatic  interactions between the biopolymers and its solvation milieu.  ","palabras_clave":"BIOPOLYMER|GELATION|PHASE TRANSITIONS|KINETICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19372,"idioma_id":5,"titulo":"Tendencias en la subsistencia en el Holoceno tardío en la región pampeana, Argentina: el caso del sitio La Toma (partido de Coronel Pringles, provincia de Buenos Aires)","resumen":"La Toma es un sitio a cielo abierto localizado en la margen izquierda del río Sauce Grande (Partido de Coronel Pringles, provincia de Buenos Aires, Argentina). Fue excavado durante la década de 1980, momento en el cual se definieron componentes culturales asociados a ocupaciones de cazadores-recolectores correspondientes al Holoceno tardío. En este trabajo se presenta el reanálisis de la colección faunística de La Toma, considerando la cronología de las muestras. Se evalúa la estructura taxonómica y anatómica del conjunto y se desarrolla el análisis de distintas modificaciones óseas. A partir de criterios zooarqueológicos y tafonómicos, así como también estratigráficos, se comparan las tendencias en la subsistencia intra-sitio. Finalmente, la información obtenida es integrada con los modelos regionales disponibles, los cuales discuten la existencia de un proceso areal de intensificación.","palabras_clave":"REGION PAMPEANA|HOLOCENO TARDIO|SUBSISTENCIA|SITIO LA TOMA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19373,"idioma_id":4,"titulo":"The anatomy of an albite-type granitic pegmatite from the Totoral pegmatite field, San Luis, Argentina","resumen":"The Independencia Argentina albite-type granitic pegmatite is the most distal differentiate in the Cerro La Torre pegmatite group, located in the Eastern Pampean Ranges of Argentina. It is a  zoned pegmatite formed at two main stages that probably shared the same origin but had separate evolutions. The product of the first stage was a pegmatite dominated by albite, quartz and muscovite, with rare K-feldspar and muscovite + albite pseudomorphs after spodumene, and accessory  columbite-group minerals, beryl, fluorapatite as well as garnet. This first-stage pegmatite was emplaced forcefully and crystallized syn-kinematically. Resulting boudinage and necking-down produced the main body, bulbous in shape and asymmetric in zoning. This pegmatite was subsequently intruded by a melt that solidified to a very fine-grained, saccharoidal albite unit, composed in excess of 97 % by Ab99.1?99.6, with accessory columbite-group minerals and fluorapatite. The normative mineral composition of this unit corresponds very well with that of the experimental products of protracted fractionation of rare-element pegmatite melts, with high Na\/K ratios and HFSE enrichment. The spatial and temporal association of the two pegmatitic melts, one enriched in H2O and the other one more evolved, Na-rich, almost alkaline and flux-bearing, strongly suggests that the two are cogenetic. They probably represent products of a rare-element pegmatite magma differentiation at depth that were extracted at different stages of its crystallization and emplaced at higher crustal levels.","palabras_clave":"Pegmatite|Albite-type|HFSE flux-rich melt|two-stage process"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19374,"idioma_id":4,"titulo":"THE ROLE OF BIOCLIMATIC ARCHITECTURE IN THE REDUCTION OF THE EMISSION OF CO2 IN ARID ENVIRONMENTS","resumen":"The energy consumption for energy conditioning using natural\/liquefied gas and electric power of the San Juan?s Metropolitan Area housing is studied. The study quantifies the savings that could be obtained if dwellings had been designed bearing in mind concepts of bioclimatic architecture. Estimates the CO2 emissions in both cases: a conventional house and another designed using natural energies. It is concluded that, in the second case, there would be a decrease of 74% of CO2 emissions. If this reduction is for electric power saving, the decrease would be 84% and if by natural\/liquefied gas savings: 56%. Quantifying the complete housing of the city, the decrease in the total carbon footprint using bioclimatic design strategies would be 72%.","palabras_clave":"Carbon footprint|bioclimatic architecture|arid environments"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19375,"idioma_id":4,"titulo":"Thermal ecology of the post-metamorphic Andean toad (Rhinella spinulosa) at elevation in the Monte Desert, Argentina","resumen":"Rhinella spinulosa is an anuran toad species distributed latitudinal and altitudinal (1200 to 5000 meters) from Peru to Argentina, inhabiting mountain valleys in the Andes. Considering the broad range of habitats where they live, it is important to understand the thermal physiological mechanisms, thermal tolerances and physiological adaptations for surviving in rigorous environments. We investigated the thermal parameters (field body temperature, selected body temperature, locomotor performance in field and laboratory conditions, and thermal extremes) during diurnal activity for a population of juvenile, post?metamorphosed toads (Rhinella spinulosa) from the Monte Desert of San Juan, Argentina. Post-metamorphic toads are active from approximately 1100 to 1900 (in contrast to nocturnal adult toads). Our findings show that these toads have a wide thermal tolerance range, ranging from a critical thermal maximum of 36.9 °C to crystallization temperatures below 0 °C. During their active period, toads always showed suboptimal thermal conditions for locomotion. Despite the suboptimal condition for the locomotion, diurnal activity is likely to confer thermal advantages, allowing them to search for food and increase digestion and growth rates. We also found that the toads are capable of super-cooling, which prevents mortality from freezing when the environmental temperatures drop below 0 °C. The environmental temperatures are below zero at night, when toads are inactive and take refuge under rocks. In summary, this toad population demonstrates high thermal plasticity, as shown by a relatively high level of activity sustained over a wide range of ambient temperature (~ 35 ºC). These thermal adaptations allow this species of juvenile toads to inhabit a wide range of altitudes and latitudes.","palabras_clave":"RHINELLA SPINULOSA|SUPER ENFRIAMIENTO|ECOLOGIA TERMICA|RENDIMIENTO LOCOMOTOR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19376,"idioma_id":4,"titulo":"Dietary and pharmacological compounds altering the intestinal Ca absorption in humans and animals","resumen":"The intestine is the only gate for the entry of Ca2+ to the body in humans and mammals. The entrance of Ca2+ occurs via paracellular and intracellular pathways. All steps of the latter pathway are regulated by calcitriol and by other hormones. Dietary and pharmacological compounds also modulate the intestinal Ca2+ absorption process. Among them, dietary calcium and phosphorus are known to alter the lipid and protein composition of the brush border and basolateral membranes and, consequently, the Ca2+ transport. Calcium intakes are below the requirements recommended by health professionals in most countries triggering important health problems. Chronic low Ca2+ intake has been related to ill conditions such as osteoporosis, hypertension, renal lithiasis and incidences of human cancer. Carbohydrates, mainly lactose, and prebiotics have been described as positive modulators of the intestinal Ca2+ absorption. Apparently, high meat proteins increase the intestinal Ca2+ absorption while the effect of dietary lipids remains unclear. Pharmacological compounds such as menadione, DL-butionine-S,R-sulfoximine and ursodeoxycholic acid also modify the intestinal Ca2+ absorption as a consequence of altering the redox state of the epithelial cells. The paracellular pathway of the intestinal Ca2+ absorption is poorly known and is under current study in some laboratories. Another field that needs to be explored more intensively is the influence of the gene-by diet interaction on intestinal Ca2+ absorption. Health professionals should be aware of this knowledge in order to develop nutritional or medical strategies to stimulate the efficiency of intestinal Ca2+ absorption and to prevent diseases.","palabras_clave":"INTESTINAL CA ABSORPTION|TRANSCELLULAR AND PARACELLULAR PATHWAY|HORMONAL EFFECTS|NUTRITIONAL FACTORS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19377,"idioma_id":4,"titulo":"Combined Flubendazole-Nitazoxanide treatment of cystic echinococcosis: pharmacokinetic and efficacy assessment in mice","resumen":"tThe current chemotherapy of cystic echinococcosis (CE) is mainly based on the use of albendazole, andthe results have been shown to be highly variable. Thus, new and more efficient treatment options areurgently needed. The goals of the current study were: a) to compare the ex vivo activity of flubendazole(FLBZ) and nitazoxanide (NTZ), given either separately or co-administered, against Echinococcus granulo-sus protoscoleces and cysts, b) to characterize the plasma disposition kinetics of FLBZ administered aloneor combined with NTZ in mice; (c) to compare the in vivo activity of FLBZ and NTZ (either each alone or asa combined treatment) against secondary CE developed in mice. Ex vivo drug activity study: E. granulosusprotoscoleces and cysts were incubated either with FLBZ, NTZ, or the FLBZ-NTZ combination. Proto-scoleces and cyst viability was monitored by the methylene blue exclusion test and scanning electronmicroscopy (SEM). Pharmacokinetic study: Balb\/C mice received FLBZ (5 mg\/kg) orally either alone or co-administered with NTZ (100 mg\/kg). Blood samples were collected up to 12 h post treatment and plasmaanalyzed for FLBZ\/metabolites by HPLC. Clinical Efficacy study: following secondary infection, meaningi.p. injection of 1500 E. granulosus protoscoleces\/animal (n = 40), the both drugs were administered byintragastric inoculation on a daily basis for a period of 25 days. Balb\/C mice received FLBZ (5 mg\/kg, twicea day) alone, NTZ (100 mg\/kg, once daily) alone or a combination of both molecules (FLBZ, 5 mg\/kg twicea day and NTZ, 100 mg\/kg, once daily). Ten untreated animals were used as a control. All animals werekilled and the weight of the cysts collected from each animal was recorded. The presence of NTZ didnot markedly affect the FLBZ kinetic parameters in mice. FLBZ alone or combined with NTZ induced areduction (P < 0.05) of cyst weight in comparison to the untreated control and NTZ-treated treated mice.The data obtained here indicate that NTZ did not affect hydatid cyst development in mice. Conversely,FLBZ shows an excellent efficacy against CE.","palabras_clave":"Echinococcus granulosus|flubendazole|nitazoxanide|cystic echinococcosis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19378,"idioma_id":4,"titulo":"Relationship between MODIS-NDVI data and wheat yield. A case study in Northern Buenos Aires province, Argentina","resumen":"In countries like Argentina, whose economy depends heavily on crop production, the estimation of harvests is an elementary requirement. Besides providing objectivity, the use of remote sensing allows estimating yield in advance. Since the time of maximum leaf area in wheat corresponds with the critical period of the crop, a good relationship is expected between the Normalized Difference Vegetation Index (NDVI) and yield. The present study was carried out in the North of Buenos Aires province, Argentina. Based on the type of soil, the study area can be divided into two homogeneous subzones: a subzone with lower clay content in the southwest and a subzone with higher clay content in the northeast. Nine growing seasons (2003?2011) were studied. In the first five years, an empirical model was calibrated and validated with field-observed wheat yields and MOD13q1 product-NDVI data, whereas in the other four years, the calibrated model was applied by means of yield maps and by comparing with official yields. The MOD13q1 image corresponding to Julian day 289 showed the best fit between NDVI and yield to estimate wheat yield early. Through yield maps, better weather conditions showed higher yields and higher soil productivity presented a greater proportion of the area occupied by higher yields. At department level, an R2 value of 0.75 was found after relating the estimation of the calibrated empirical model with official yields. The method used allows predicting wheat yield 30 days before harvest. Through yield maps, the NDVI perceived the temporal and spatial variability in the study area.","palabras_clave":"REMOTE SENSING|WHEAT|NDVI|MODIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19379,"idioma_id":4,"titulo":"Latitudinal differences in life-history traits and parental care in northern and southern temperate zone House Wrens","resumen":"South temperate songbirds differ from north temperate species in life-history traits, having greater adult survival, smaller clutch size, longer developmental periods and extended parental care. Due to its broad distribution, the House Wren, Troglodytes aedon, is an excellent model to evaluate selective pressures that may influence the maintenance of present clutch size. Here we report data on life-history traits and parental care of socially monogamous House Wrens from a north temperate and a south temperate population. Southern House Wrens exhibited smaller clutch sizes and longer developmental periods than Northern House Wrens; however we did not find significant differences in adult survival probability between populations, contrary to a critical prediction of the cost of reproduction hypothesis. Our data did not support the hypothesis that smaller clutches are the consequence of greater food limitation in the south; southern wrens have greater adult body mass but smaller territories, southern nestlings reached a greater proportion of adult body mass 6-7 days before fledgling and provisioning rates to the nest per nestling were greater in the south. We did not find support for the hypothesis that reduced clutch size is a consequence of limited parental activity at the nest as southern wrens did not reduce parental care during the incubation and nestling stage. Our data better supports the offspring quality hypothesis; southern wrens invest more per nestling than northern wrens as provisioning rates per nestling were significantly higher and developmental periods longer in the south. Published results from Tropical House Wrens suggest that neither food limitation nor nest predation can explain reduced clutches in Central America. We suggest that south temperate and tropical wrens may differ in parental investment strategies as tropical wrens seem to invest even less per nestling than north temperate wrens.","palabras_clave":"LIFE-HISTORY TRAITS|BREEDING BIOLOGY|PARENTAL CARE|HOUSE WREN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19380,"idioma_id":4,"titulo":"Experimental studies of boronophenylalanine (10BPA) biodistribution for the individually tailored application of boron neutron capture therapy (BNCT) for malignant melanoma treatment","resumen":"Purpose: Patients with the same histopathological diagnosis of cutaneous melanoma treated with identical protocols of boron neutron capture therapy (BNCT), have shown different clinical outcomes. The objetive of the present studies was to evaluate in an experimental model the biodistribution of boronphenylalanine (10BPA) for the potential application of BNCT for the treatment of melanoma on an individual basis. Methods and Materials: The boronophenilalanine (BPA) uptake was evaluated in three human melanoma cell lines MEL-J, A375 and M8. Biodistribution studies of BPA (350 mg\/Kg i.p) were performed in NIH nude mice bearing melanoma (MEL-J) tumors. Static Infrared Imaging (SIRI) utilizing a specially modified infrared camera adapted to measure the body infrared radiance of small animals, was employed. Proliferation marker, Ki-67 and endothelial marker, CD31, were analysed in tumor samples. Results: The in vitro studies demonstrated different patterns of BPA uptake for each analysed cell line (*** p < 0.001 for MEL-J and A375 vs. M8 cells). The in vivo studies showed a maximum average boron concentration of 25.9 ± 2.6 µg\/g in tumor, with individual values ranging between 11.7 and 52.0 µg\/g of 10B at 2 h post-injection of BPA. Tumor temperature always decreased as the tumors increased in size, with values ranging between 37 ºC and 23 ºC. A significant correlation between tumor temperature and tumor-to-blood boron concentration ratio was found (R-square=0.7, rational function fit). The immunohistochemical studies revealed, in tumors with extensive areas of viability, a high number of positive cells for Ki-67, blood vessels of large diameter evidenced by the marker CD31 and a direct logistic correlation between proliferative status and boron concentration difference between tumor and blood (R-square=0.81, logistic function fit). Conclusion: We propose that these methods could be suitable for designing new screening protocols applied prior to melanoma BNCT treatment for each individual patient and lesion","palabras_clave":"BNCT|MELANOMA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19381,"idioma_id":4,"titulo":"Carbon acquisition strategies uncoupled from predictions derivedfrom species life-cycle","resumen":"tWe compare carbon use strategies of congeneric annual (P. gracilis and P. angustifolia) and perennial(P. mendocina and P. pinetorum) Physaria (Brassicaceae), to evaluate the relevance of eco-physiologicaltraits as determinants of differences in growth and to add information on the current debate on theagro-ecological suitability of perennial species for grain production in low resource ecosystems. Becauseof differences in growth and in seed-output previously found within this genus, we hypothesized thatC acquisition strategies would not be fully coupled with predictions derived from a species life-cycle.Further, we expected to find different suites of traits related to C-acquisition among perennial species ofPhysaria. We found species with high (P. gracilis and P. pinetorum) and low (P. mendocina and P. angustifolia)relative growth rate (RGR) and biomass. The variation in RGR was linked to differences in specific leafarea (SLA) and allocation to leaves (leaf mass ratio, LMR) and roots (root mass ratio, RMR), but not tothe species life-cycle. Physaria gracilis had high allocation to leaf area (leaf area ratio, LAR), LMR, highSLA, and low RMR and carbohydrates reserves. The slow-growth strategy found in P. mendocina waslinked to low LAR, low SLA and large below-ground allocation. The other species showed intermediatestrategies between these two. The sets of traits present in P. gracilis and in P. mendocina are extremes inthe C acquisition?conservation trade-off, and may allow them to cope with low resource environmentsin different ways. SLA, LMR and RMR were the main determinants of RGR, while total non-structuralcarbohydrates (TNC) and leaf longevity were linked to the life-cycle. Taken together these charactersdefine the intermediate growth strategies of P. angustifolia and P. pinetorum. These intermediate strategieswere not dependent on the species life cycle and support the hypothesis of uncoupled relationshipsbetween growth, C acquisition strategies and life-cycle.","palabras_clave":"RELATIVE GROWTH RATE|C ACQUISITION-CONSERVATION TRADE-OFF|PHYSARIA|NEW CROPS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19382,"idioma_id":4,"titulo":"Acantholippia seriphioides: Chemical biodiversity of wild populations from the Cuyo region in Argentina","resumen":"Nineteen samples from the aerial parts in bloom of Acantholippia seriphioides (Verbenaceae) were collected in three provinces belonging to the Cuyo region of Argentina. The essential oils were obtained by hydrodistillation, yielding between 0.57 and 2.46% (v\/w). On the basis of the 13 main compounds determined by GC-FID-MS, representing the 87.2 and 95.3% of the total identified, four chemotypes were determined: carvacrol, thymol, cis and trans-dihydrocarvone and linalool-geraniol. The co-occurrence of different chemotypes in a same population indicates that the sample collection must be carefully done with the aid of an in situ olfactory testing of the plants, since no morphological differences at first sight were observed among them. The results showed in this study suggest that the pattern of variations for this species exists throughout its natural distribution area.","palabras_clave":"Acantholippia seriphioides|Argentina|Essential Oils|Chemical Biodiversity"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19383,"idioma_id":4,"titulo":"Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus.","resumen":"EVER1 and EVER2 are mutated in epidermodysplasia verruciformis patients, who are susceptible to human betapapillomavirus (HPV) infection. It is unknown whether their products control the infection of other viruses. Here, we show that the expression of both genes in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed via activation of the NF-&#954;B signaling pathway by latent membrane protein 1 (LMP1). Ectopic expression of EVER1 impairs the ability of EBV to infect B cells.","palabras_clave":"EVER1|EVER2|EBV-LMP1|BCELLS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19384,"idioma_id":4,"titulo":"Identification of G protein coupled receptors for opsines and neurohormones in Rhodnius prolixus. Genomic and transctiptomic analysis","resumen":"The importance of Chagas disease motivated the scientific effort to obtain the complete genomic sequence of the vector species Rhodnius prolixus, this information is also relevant to the understanding of triatomine biology in general. The central nervous system is the key regulator of insect physiology and behavior. Neurohormones (neuropeptides and biogenic amines) are the chemical messengers involved in the regulation and integration of neuroendocrine signals. In insects, this signaling is mainly mediated by the interaction of neurohormone ligands with G protein coupled receptors (GPCRs). The recently sequenced R. prolixus genome provides us with the opportunity to analyze this important family of genes in triatomines, supplying relevant information for further functional studies. Next-generation sequencing methods offer an excellent opportunity for transcriptomic exploration in key organs and tissues in the presence of a reference genome as well as when a reference genome is not available. We undertook a genomic analysis to obtain a genome-wide inventory of opsines and the GPCRs for neurohormones in R. prolixus. Furthermore, we performed a transcriptomic analysis of R. prolixus central nervous system, focusing on neuropeptide precursor genes and neurohormone and opsines GPCRs. In addition, we mined the whole transcriptomes of Triatoma dimidiata, Triatoma infestans and Triatoma pallidipennis ? three sanitary relevant triatomine species ? to identify neuropeptide precursors and GPCRs genes. Our study reveals a high degree of sequence conservation in the molecular components of the neuroendocrine system of triatomines.","palabras_clave":"CHAGAS DISEASE|INSECT|TRIATOMA|TRANSCRIPTOME|NEUROPEPTIDES|GPCRS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19385,"idioma_id":5,"titulo":"El Inca antes de la llegada española en el valle de Hualfín, Catamarca.","resumen":"El Imperio Incaico se desarrolló como el sistema político más grande y quizás más complejo en América del Sur antes de la llegada española (1430 d.C.-1532 d.C.). Fue un Estado expansivo que incorporó un amplio territorio de la América prehispánica, extendiéndose desde el sur de Colombia hasta Chile y Argentina a lo largo de la Cordillera Andina, recorriendo más de 4000 Km.","palabras_clave":"IMPERIO INCAICO|VALLE DE HUALFÍN|CATAMARCA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19386,"idioma_id":4,"titulo":"From the epididymis to the egg: participation of   CRISP proteins in mammalian fertilization","resumen":"Mammalian fertilization is a complex process that involves different steps of interaction between the male and female gametes. In spite of its relevance, the molecular mechanisms underlying this process still remain to be elucidated. The present review describes the contribution of our laboratory to the understanding of mammalian fertilization using Cysteine-RIch Secretory Proteins(CRISP) as model molecules. Substantial evidence obtained from in vitro assays and knockout models shows that epididymal CRISP1 associates with the sperm surface with two different affinities during maturation, and participates in the regulation of signaling pathways during capacitation as well as in both sperm&#8209;zona pellucida interaction and gamete fusion. These observations can be extended to humans as judged by our findings showing that the human homolog of the rodent protein (hCRISP1) is also involved in both stages of fertilization. Evidence supports that other members of the CRISP family secreted in the testes (CRISP2), epididymis (CRISP3&#8209;4) or during ejaculation (CRISP3) are also involved in sperm&#8209;egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. Together, our observations indicate that CRISP proteins accompany spermatozoa along their transit through both the male and female reproductive tracts.We believe these results not only contribute to a better mechanistic understanding of fertilization but also support CRISP proteins as excellent candidates for future research on infertility and contraception.","palabras_clave":"Cysteine RIch Secretory Proteins|epididymal proteins|fertilization|sperm"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19388,"idioma_id":4,"titulo":"The pan-caspase inhibitor emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis","resumen":"Background: Hepatocyte apoptosis, the hallmark of Non-alcoholic steatohepatitis (NASH) contributes to liver injury and fibrosis. Although, both the intrinsic and extrinsic apoptotic pathways are involved in the pathogenesis of NASH, the final common step of apoptosis is executed by a family of cysteine-proteases termed caspases.  Thus, our aim was to ascertain if administration of Emricasan, a pan-caspase inhibitor, ameliorates liver injury and fibrosis in a murine model of NASH. Methods: C57\/BL6J-mice were fed regular chow or high fat diet (HFD) for 20 weeks. All mice were treated with vehicle or Emricasan.  Results: Mice fed a HFD diet demonstrate a 5-fold increase in hepatocyte apoptosis by the TUNEL assay and a 1.5-fold and 1.3-fold increase in caspase-3 and-8 activities respectively; this increase in apoptosis was substantially attenuated in mice fed a HFD treated with Emricasan (HFD-Em). Likewise, liver injury and inflammation were reduced in mice fed  HFD-Em as compare to HFD by measuring serum AST and ALT levels, NAS histologic score and IL 1-â, TNF-á, MCP-1 and CXCL2 qPCR. These differences could not be attributed to differences in hepatic steatosis as liver triglycerides content were similar in both HFD groups. Hepatic fibrosis was reduced by Emricasan in HFD animals by decreasing áSMA (a  marker for HSC activation), fibrosis score, Sirius red staining, hydroxyproline liver content and profibrogenic cytokines by qPCR. In Conclusion, these data demonstrate that in a murine model of NASH, liver injury and fibrosis are suppressed by inhibiting hepatocytes apoptosis and suggests that Emricasan may be an attractive anti-fibrotic therapy in NASH.","palabras_clave":"NASH|APOPTOSIS|CIRRHOSIS|CASPASE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19389,"idioma_id":5,"titulo":"TECNOLOGÍA Y USO DE MATERIAS PRIMAS  EN PUNTAS COLA DE PESCADO DE LA MESETA DE SOMUNCURÁ  (PROVINCIA DE RÍO NEGRO, ARGENTINA)","resumen":"Se presentan análisis tecnológicos realizados sobre un conjunto de puntas cola de pescado registrado en sitios en torno a la laguna De Las Vacas, en la Meseta de Somuncurá (provincia de Río Negro, Argentina).  Se comparan el uso de las materias primas y determinados atributos tecnológicos de dichos artefactos. Finalmente se discuten las variables analizadas en relación a la producción y descarte de puntas cola de pescado en este sector del espacio norpatagónico.","palabras_clave":"Fishtail points|Lithic technology|Meseta |Somuncurá"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19390,"idioma_id":5,"titulo":"Los edenes en el desierto, señales en la historia de la colonización de Patagonia argentina","resumen":"Presentamos una serie de reflexiones sobre la exploración y el tiempo deaprendizaje de los ambientes nuevos durante la colonización inicial de América. Consideramos elementos teóricos provenientes de la arqueología y de otros campos disciplinares, con el objetivo de enmarcar los procesos a los que se enfrentan los grupos humanos al migrar y conocer espacios deshabitados. Estos paisajes sin historia fueron convertidos en paisajes sociales a través de prácticas desarrolladas a lo largo del tiempo. Desde la perspectiva del aprendizaje ambiental, se analizan ocupaciones humanas correspondientes a la transición Pleistoceno-Holoceno y al Holoceno Temprano de sitios arqueológicos de la Patagonia argentina, con el fin de aportar datos relativos a los modos y tiempos del  aprendizaje del ambiente, la materialidad y la distribución de las primeras ocupaciones en terrenos desconocidos.","palabras_clave":"Poblamiento inicial|Paisaje arqueologico|Lugares|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19391,"idioma_id":4,"titulo":"Functional and histopathological changes induced by intraparenchymal injection of kainic acid in the rat cervical spinal cord","resumen":"Kainic acid (KA) is an analog of the neurotransmitter glutamate and is widely used as an excitotoxic agent to lesion spinal cord networks, thus, providing an interesting model to learn basic mechanisms of spinal cord injury. The present work was aimed to evaluate motor and sensory performance of rats and analyze morphometric parameters of spinal cord neurons after KA injection. Animals were injected either with 0.75, 1 or 1.25 mM of KA at the C5 segment of the cervical spinal cord. Motor and sensory performance of the rats were evaluate at day 0 (before injection) and at days 1, 2, 3 and 7 post-injection (pi) and compared with those of saline-treated and non-operated animals. Animals were sacrificed at each time point for morphometric and histopathological analysis and compared among groups. All KAtreated animals showed a significant impairment at the motor and sensory tests for the ipsilateral forelimb in a concentration-dependent manner in comparison to saline-treated and  non-operated animals. Neuronal cell count showed a significant loss of neurons at C4, C5 and C6 cervical segments when compared with those of saline-treated and non-operated animals. The contralateral side of the cervical segments in KA-treated rats remained unchanged. Some improvement at the motor and sensory tests was observed in animals injected with 0.75 and 1 mM KA. Moreover, a mild increase in the neuronal  count of the damaged segments was also recorded. The improvement recorded in the motor and sensory tests by day 7 pi may be a consequence of a neuron repairing mechanism triggered soon after the KA excitotoxic effect.","palabras_clave":"Kainic acid |Cervical segments |Spinal cord |Morphometric analysis |Rat"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19392,"idioma_id":4,"titulo":"Influence of pH and antibiotic solubility on the removal of ciprofloxacin from aqueous media using montmorillonite","resumen":"The ciprofloxacin (CPX) is a fluoroquinolone antibiotic that has been found in soils and aqueous media due to its vast use in both, human and veterinary health care. As a consequence the removal of this kind of compounds is widely studied. However, there are a few studies about the CPX removal from aqueous media by adsorption. Thiswork is focused on the study of CPX removal by adsorption using an Argentinian montmorillonite (Mt). The influence of the pH media and the consequent antibiotic solubility in the adsorption process was analyzed.  The experimental curve of CPX solubility versus pH media showed a strong correlation between them where the lowest value of solubility was obtained for the zwitterion species (CPX±). This result points out the fact that the solubility of the CPX speciesmust be considered in adsorption experiments because of the antibiotic precipitation and the consequent overestimation of the adsorbent adsorption capacities. CPX adsorption kinetics and adsorption isotherms at different pH values showed that the adsorption processes obey pseudo-second order kinetics. The CPX adsorption capacity of the Mt, the affinity of the species towards its surface and the possible mechanisms involved in the adsorption process were assessed by Langmuir, Freundlich and Scatchard methods. The results showed that the adsorption mechanism of CPX on Mt is pH dependent, obtaining a negative cooperative mechanism at pH 3, 6 and 7.5 and a positive cooperative mechanism at pH 10. The highest CPX adsorption capacity on Mt was obtained at pH 6. Infraredspectroscopy and X-ray diffractograms of the complexes obtained after the adsorption process provided information about the interaction between the functional groups of CPX and the adsorption sites on Mt and the changes in the basal space relatedwith the molecular arrangements of the CPX on the sample, respectively. The CPX removal by this clay mineral is remarkably higher when it is compared with other materials and quite similar to previous data obtained with other bentonites.","palabras_clave":"Ciprofloxacin|Solubility|Adsorption |Montmorillonite"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19393,"idioma_id":4,"titulo":"Lead exposure affects health indices in free-ranging ducks in Argentina","resumen":"Numerous experiments under controlled conditions and extensive investigation of waterfowl die-offs have demonstrated that exposure to lead from spent gunshot is highly detrimental to the health of waterfowl. However, few studies have focused on examining the more subtle sub-lethal effects of lead toxicity on ducks in non-experimental settings. In our study, the health of ducks exposed to varying amounts of lead under natural conditions was assessed by correlating individual lead exposure with relevant indices of health. Based on hunter-killed wild ducks in Argentina, we measured spleen mass, body condition, examined bone marrow smears, and determined Ca and P in bone tissue. In free-ranging live-trapped ducks we determined basic hematology and aminolevulinic acid dehydratase activity. Using multivariate analyses, we found that, when controlling for the potential confounding effect of site type, year, duck species, body mass and age, lead levels in the liver were negatively associated with body condition and spleen mass. Spleen mass was also lower in ducks with higher lead levels in their bones. In live ducks, high blood lead levels were associated with low packed cell volume and red cell morphologic abnormalities. These findings suggest that, despite the lack of recorded lead-induced mortality in the region, lead exposure results in less conspicuous but still significant impacts on the health of ducks, which could have serious implications for their conservation. Moreover, this evidence further supports the need for urgently banning lead shot in the region.","palabras_clave":"plomo|municiones|saturnismo|patos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19394,"idioma_id":4,"titulo":"The redox-active nanomaterial toolbox for cancer therapy","resumen":"Advances in nanomaterials science contributed  in recent years to develop new devices and systems in the micro and nanoscale  for improving the diagnosis and treatment of cancer. Substantial evidences  associate cancer cells and tumor microenvironment with reactive oxygen species  (ROS), while conventional cancer treatments and particularly radiotherapy, are  often mediated by ROS increase. However, the poor selectivity and the toxicity  of these therapies encourage researchers to focus efforts in order to enhance delivery  and to decrease side effects. Thus, the development of redox-active nanomaterials  is an interesting approach to improve selectivity and outcome of cancer  treatments. Herein, we describe an overview of recent advances in redox  nanomaterials in the context of current and emerging strategies for cancer therapy  based on ROS modulation.","palabras_clave":"CANCER|NANOMATERIALS|REACTIVE OXYGEN SPECIES|TUMOR MICROENVIRONMENT|REDOX|CHEMOTHERAPY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19395,"idioma_id":4,"titulo":"DICLOFENAC SODIUM UV DEGRADATION","resumen":"Diclofenac sodium (2- [2 - [(2,6-dicloro-fenil) amino] phenyl] sodium acetate) is an nonsteroidal anti-inflammatory drug widely used today as an analgesic, anti-arthritic and anti-rheumatic. It is susceptible to stress caused by UV radiation. In this work photodegradation of diclofenac was monitored in batch mode using a photolysis orthogonal chamber. Diclofenac aqueous solutions of pH 9 were subjected to the effect of UV radiation of 254nm from a mercury lamp UVP with wood glass, located at 15 cm from the liquid surface. UV Spectra of solutions exposed for periods of time in the range of 5 minutes to 48 h were scanned. Diclofenac molecule without UV treatment exhibits a maximum at 195 nm and another at 276 nm. At very short treatment times a peak appears around 239 nm, where in the original molecule the absorbance is minimal. Another peak begins to emerge at 289 nm, which becomes more apparent at times of treatment longer than 1 hour. Simultaneously in greater times peaks at 225 and 250 nm appear. The absorptiometric measurements were complemented by the application of quantum theoretical chemistry using the static approximation and density functional theory, B3LYP. The excitations energies B3LYP for diclofenac and for the photolysis products are closed with the experimental measurements. Based on this, a mechanism for the reaction of photolytic degradation of diclofenac in the tested conditions is proposed","palabras_clave":"DICLOFENAC|UVRADIATION|PHOTODEGRADATION|QUANTUM THEORETICAL CHEMISTRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19396,"idioma_id":4,"titulo":"'Using trait-based approaches to study phytoplankton seasonal succession in a subtropical Reservoir in arid central western Argentina","resumen":"Abstract The application of trait-based approaches has become a widely applied tool to analyse community assembly processes and dynamics in phytoplanktoncommunities. Its advantages include summarizing information of many species without losing essentials of the main driving processes. Here, we used trait-based approaches to study phytoplankton temporal succession in a subtropical reservoir. We applied a combined approach including morphological traits (i.e. volume, surface) and functional clustering of species (morphologybased functional groups (MBFG) and Reynolds? groups) and related the clustering of species with theenvironment. We found that this reservoir is characterized by a low richness and a bimodal distribution of phytoplankton biomass. Taxonomic and functional classifications were coincident, and the dominant species and groups biomasses were explained by the same group of variables. For instance, group X2, MBFG Vand Carteria sp. biomasses were explained by: pH, Secchi disk depth, N-NH4; while group B, MBFG VI and Cyclotella ocellata biomasses were explained bystability of the water column, incident solar radiation, Secchi disk depth and N-NH4. From our results, we state that functional and taxonomic classifications are complementary rather than opposed approaches, and their specific uses depend exclusively on the aim of the study and the characteristics of the environment under evaluation. Our work is the first description of phytoplankton dynamics in a reservoir in the arid central western Argentina (Cuyo region).Keywords Functional groups . Morphological traits .Reservoirs . Argentina","palabras_clave":"Functional Groups|Morphological traits|Reservoirs|phytoplankton"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19397,"idioma_id":4,"titulo":"Association of Toll-like receptor 2 Arg753Gln and Toll-like receptor 1 Ile602Ser single-nucleotide polymorphisms with leptospirosis in an argentine population","resumen":"Toll-like receptor 2 (TLR2), a member of the Toll-like receptor family, plays an50 important role in the recognition of and subsequent immune response activation51 against leptospirosis in humans. The genetic polymorphism in TLR2 of an arginine to52 glutamine substitution at residue 753 (Arg753Gln) has been associated with a53 negative influence on TLR2 function, which may, in turn, determine the innate host54 response to Leptospira spp. This bacterium signals through TLR2\/TLR155 heterodimers in human cells. The aim of the present study was to investigate the56 Arg753Gln single-nucleotide polymorphism (SNP) of the TLR2 gene, and the57 isoleucine to serine transversion at position 602 (Ile602Ser) of the TLR1 gene58 (previously associated with Lyme disease), in leptospirosis patients compared to59 healthy controls, carrying out a retrospective case\/control study. The TLR260 polymorphism adenine (A) allele was observed in 7.3% of leptospirosis patients but61 was not found in the control group, whereas the guanine (G) allele of the TLR162 polymorphism was found in 63.6% of patients and 41.6% of controls. Susceptibility to63 leptospirosis disease was increased 10.57-fold for carriers of the TLR2 G\/A64 genotype (P=0.0493) and 3.85-fold for carriers of the TLR1 G\/G genotype65 (P=0.0428). Furthermore, the risk of developing hepatic insufficiency and jaundice66 was increased 18.86- and 27.60-fold for TLR2 G\/A carriers, respectively. Similarly,67 the risk of developing jaundice was increased 12.67-fold for TLR1 G allele carriers68 (G\/G and T\/G genotypes). In conclusion, the present data suggest that the TLR269 Arg753Gln and TLR1 Ile602Ser SNPs influence the risk of developing leptospirosis70 and its severity.","palabras_clave":"Leptospirosis|human TLR2|human TLR1|SNP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19398,"idioma_id":4,"titulo":"Transport mechanisms in nanopores and nanochannels: can we mimic nature?","resumen":"The last few years have witnessed major advancements in the synthesis,   modification, characterization and modeling of nanometer-size   solid-state channels and pores. Future applications in sensing, energy   conversion and purification technologies will critically rely on   qualitative improvements in the control over the selectivity,   directionality and responsiveness of these nanochannels and nanopores.   It is not surprising, therefore, that researchers in the field seek   inspiration in biological ion channels and ion pumps, paradigmatic   examples of transport selectivity. This work reviews our current   fundamental understanding of the mechanisms of transport of ions and   larger cargoes through nanopores and nanochannels by examining recent   experimental and theoretical work. It is argued that that structure and   transport in biological channels and polyelectrolyte-modified synthetic   nanopores are strongly coupled: the structure dictates transport and   transport affects the structure. We compare synthetic and biological   systems throughout this review to conclude that while they present   interesting similarities, they also have striking differences.","palabras_clave":"Theory"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19399,"idioma_id":4,"titulo":"Molecular Dynamics Simulations of Anchored Viral Peptide Interactions","resumen":"ver pdf","palabras_clave":"Theory"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19400,"idioma_id":4,"titulo":"Nucleotide Sequence of Key Genes from the Biosynthetic Pathway of the  Major Flavonoid in ?Malbec? and ?Cabernet Sauvignon?","resumen":"In red wines, important sensory attributes such as color and astringency are the result of the accumulation of anthocyanins, which are located in the berry skin (and in the pulp of teinturier cultivars). Each cultivar has a unique set of anthocyanins and both qualitative and qualitative anthocyanin composition at harvest are crucial factors for winemaking. Anthocyanins are synthesized through the so-called phenylpropanoid pathway. Vitis vinifera L. ?Malbec? and ?Cabernet Sauvignon? are red cultivars adapted to similar environmental conditions. Both cultivars are usually cropped to have from medium to low yields to ensure the production of premium and ultra-premium wines. Although ?Malbec? has significant differences in the dihydroflavonol concentration, being 10 times higher than in other red cultivars such as ?Cabernet Sauvignon?, this increment could be partially explained by differences in the gene sequences coding for enzymes working between the naringenin chalcone and leucoanthocyanins steps. In order to investigate the dynamics of anthocyanin accumulation in grapevines, we sequenced cDNAs coding for enzymes of the anthocyanin biosynthetic pathway isolated from grape berry skin, sampled throughout ripening from two selected clones of ?Malbec? and ?Cabernet Sauvignon?. Specific primers were synthesized using EST sequences (NCBI) for flavonoid 3?5?-hydroxylase, flavanone 3-hydroxylase, flavonol synthase and dihydroflavonol 4-reductase. Total RNA was isolated from berry skins and cDNA was used to study these gene sequences. Finally, fragments were cloned and sequenced, and compared between cultivars. The comparison of the deduced aminoacidic sequences against the reference data base show identities higher than 99% with the cultivar ?Pinot Noir? for all the enzymes, and the identified mutations do not seem to have any effect on the protein structure. When a comparison between ?Malbec? and ?Cabernet Sauvignon? sequences was performed, the identity was also higher than 99%. Our results are the basis for future investigation on the specific gene expression, and also can be used as a trigger for future assays focused on understanding the modulator effect produced by the environment on the genotypes of these worldwide cultivars.","palabras_clave":"anthocyanins|wine quality|coding sequences|dihydroflavonols|berry skin"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19402,"idioma_id":4,"titulo":"Relation between coumarate decarboxylase and vinylphenol reductase activity with regard to the production of volatile phenols by native Dekkera bruxellensis strains under 'wine-like' conditions","resumen":"Dekkera\/Brettanomyces bruxellensis is considered a major cause of wine spoilage, and 4-ethylphenol and 4-ethylguaiacol are the most abundant off-aromas produced by this species. They are produced by decarboxylation of the corresponding hydroxycinnamic acids (HCAs), followed by a reduction of the intermediate 4-vinylphenols. The aim of the present study was to examine coumarate decarboxylase (CD) and vinylphenol reductase (VR) enzyme activities in 5 native Dekkera bruxellensis strains and determine their relation with the production of ethylphenols under ?wine-like? conditions. In addition, biomass, cell culturability, carbon source utilization and organic acids were monitored during 60 days. All strains assayed turned out to have both enzyme activities. No significant differences were found in CD activity, whilst VR activity was variable among the strains. Growth of D. bruxellensis under ?wine-like? conditions showed two growth phases. Sugars were completely consumed during the first growth phase. Transformation of HCAs into ethylphenols also occurred during active growth of the yeast. No statistical differences were observed in volatile phenol levels produced by the strains growing under ?wine-like? conditions, independently of the enzyme activity previously recorded. Furthermore, our results demonstrate a relationship between the physiological state of D. bruxellensis and its ability to produce ethylphenols. Inhibition of growth of D. bruxellensis in wine seems to be the most efficient way to avoid ethylphenol production and the consequent loss of wine quality.","palabras_clave":"Dekkera bruxellensis|Volatile phenols|Enzymatic activities|Wine-like conditions"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19403,"idioma_id":4,"titulo":"Integrin &#945;v&#946;3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells.","resumen":"The interaction of lymphoid tumor cells with components of the extracellular matrix via integrin &#945;v&#946;3 allows tumor survival and growth. This integrin was demonstrated to be the membrane receptor for thyroid hormones (THs) in several tissues. We found that THs, acting as soluble integrin &#945;v&#946;3 ligands, activated growth-related signaling pathways in T-cell lymphomas (TCLs). Specifically, TH-activated &#945;v&#946;3 integrin signaling promoted TCL proliferation and angiogenesis, in part, via the upregulation of vascular endothelial growth factor (VEGF). Consequently, genetic or pharmacologic inhibition of integrin &#945;v&#946;3 decreased VEGF production and induced TCL cell death in vitro and in human xenograft models. In sum, we show that integrin &#945;v&#946;3 transduces prosurvival signals into TCL nuclei, suggesting a novel mechanism for the endocrine modulation of TCL pathophysiology. Targeting this mechanism could constitute an effective and potentially low-toxicity chemotherapy-free treatment of TCL patients.","palabras_clave":"LYMPHOID TUMOR CELLS|INTEGRIN SIGNALING|TLC PROLIFERATION|ENDOCRINE MODULATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19404,"idioma_id":4,"titulo":"'Structural and Magnetic Properties of  Zn Doped Magnetite Nanoparticles Obtained by Wet Chemical Method'","resumen":"The structural and magnetic properties of  Fe(3-x)ZnxO4 (x : 0, 0.1, 0.2, 0.5, 1) nanoparticles, prepared by wet chemical method, have been studied by X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Mössbauer spectroscopy and magnetization measurements. The nanoparticles are polyhedrical -shaped with a narrow distribution in size as it was verified by SEM. By Rietveld analysis of X-ray diffraction patterns, it was determined that the cristallytes sizes of Fe(3-x)ZnxO4 in spinel structure is in the range of 30 to 50 nm. Hysteresis cycles, measured at different temperatures (300, 200, 100, 50 and 7 K), showed an increase in saturation while temperature is diminished, as it is expected.  All samples, exhibited a high blocking temperature of about 350 K, as it was determined by ZFC-FC measurements. This fact, reveals their strongly interacting superparamagnetic nature. Real AC susceptibility increases with temperature while the imaginary part have a maximum which depends on frequency, and it is related to a critical temperature which depends on composition.  A Neel-Arrhenius dependence of frequency on the critical temperature was found for all the samples. We determined a minimum of the effective anisotropy for x = 0.2.","palabras_clave":"Magnetic nanoparticles|Zn-doped magnetite"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19405,"idioma_id":4,"titulo":"Glyphosate Loss by Runoff and Its Relationship with Phosphorus Fertilization","resumen":"ABSTRACT: The aim of this study was to evaluate the relationship between glyphosate and phosphate fertilizer application andtheir contribution to surface water runoff contamination. The study was performed in Aquic Argiudoll soil (Tezanos Pintoseries). Four treatments were assessed on three dates of rainfall simulation after fertilizer and herbicide application. The solublephosphorus in runoff water was determined by a colorimetric method. For the determination of glyphosate andaminomethylphosphonic acid (AMPA), a method based on fluorenylmethyloxycarbonyl (FMOC) group derivatization, solidphase extraction (SPE) purification, and ultrahigh-performance liquid chromatography&#8722;tandem mass spectrometry (UHPLCMS\/MS) was employed. The application of phosphorus fertilizer resulted in an increased loss of glyphosate by runoff after 1 dayof application. These results suggest the need for further study to understand the interactions and to determine appropriateapplication timing with the goal of reducing the pollution risk by runoff.","palabras_clave":"GLYPHOSATE|RUNNOFF|PHOSPHORUS FERTILIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19406,"idioma_id":4,"titulo":"Complex regulation of Prolyl-4-hydroxylases impacts root hair expansion","resumen":"Root hairs are single cells that develop by tip growth, a process shared with pollen tubes, axons, and fungal hyphae. However, structural plant cell walls impose constraints to accomplish tip growth. In addition to polysaccharides, plant cell walls are composed of hydroxyproline-rich glycoproteins (HRGPs), which include several groups of O-glycoproteins, including extensins (EXTs). Proline hydroxylation, an early post-translational modification (PTM) of HRGPs catalyzed by prolyl 4-hydroxylases (P4Hs), defines their subsequent O-glycosylation sites. In this work, our genetic analyses prove that P4H5, and to a lesser extent P4H2 and P4H13, are pivotal for root hair tip growth. Second, we demonstrate that P4H5 has in vitro preferred specificity for EXT substrates rather than for other HRGPs. Third, by P4H promoter and protein swapping approaches, we show that P4H2 and P4H13 have interchangeable functions but cannot replace P4H5. These three P4Hs are shown to be targeted to the secretory pathway, where P4H5 forms dimers with P4H2 and P4H13. Finally, we explore the impact of deficient proline hydroxylation on the cell wall architecture. Taken together, our results support a model in which correct peptidyl-proline hydroxylation on EXTs, and possibly in other HRGPs, is required for proper cell wall self-assembly and hence root hair elongation in Arabidopsis thaliana.","palabras_clave":"root hair|polarized growth|glycans|Arabidopsis|extensins|galactose"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19407,"idioma_id":4,"titulo":"Low sugar is not always good: Impact of specific o-glycan defects on tip growth in arabidopsis","resumen":"Here, by using mutants of several known enzymes of the O-glycosylation pathway of HRGPs, we addressed to what extent each specific defect on the O-glycosylation machinery impacts root hair tip growth. In addition, we refer only to Hyp-O-arabinosylation and Ser-O-galactosylation modifications of EXT and EXT-related proteins, while we have excluded Hyp O-(arabino)galactosylation, commonly present in other types of HRGP like arabinogalactan proteins, from our analysis. Finally, by molecular dynamic simulations, we propose a possible model to explore how these two specific types of O-glycan defects would affect EXT self-assembly and, ultimately, their impact on the polarized cell expansion. We use a classical EXT repetitive sequence to begin to explore how O-glycosylation might affect glycoprotein conformation and possible self-interactions in the context of polarized growth, but we are aware of the complexity and diversity of EXT and EXT-related proteins that offers several other possible scenarios.","palabras_clave":"O-GLYCANS|ROOT HAIR|TIP GROWTH|ARABIDOPSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19408,"idioma_id":4,"titulo":"Small  mammals  in  farmlands  of  Argentina:  Responses  to  organic  and conventional  farming.","resumen":"Despite the important positive role that small mammals have in agricultural systems, mainly through their contribution to food webs, few studies have been conducted on the biodiversity and abundance of this group. Considering that Argentina is one of the most important agricultural regions of the world, our objective was to assess the effect of farming practices (organic vs. conventional) on species richness and abundance of small mammals in border habitats from agroecosystems of central Argentina. We predicted that the effects of farming practices on small mammal populations would vary with the degree of habitat specialization of species. We expected higher species richness and abundance of specialist species in border habitats of organic than on conventional farms. We found that farming practices did not explain species richness; the number of species in border habitats was low with small variation between managements. Management, season and vegetation volume explained abundance of both specialist and generalist species in border habitats, but with additive effects in the former and interactive effects in the latter. During summer Calomys musculinus, C. laucha and Akodon azarae were more abundant in border habitats of organic than on conventional farms. This could be related to the highest reproductive activity of these species in this season, associated to the highest habitat quality of organic border habitats. Also, organic farms may have an important role for specialist species in poor-quality habitats at the beginning and at the end of the reproductive period (spring and autumn). Our results showed a positive trend in small mammal abundance of organic farms in farmlands under intensive agriculture. The differences between Argentinian and European agriculture systems are discussed.","palabras_clave":"Agricultural management|Small mammal abundance|Specialist species|Generalist species"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19409,"idioma_id":4,"titulo":"Do polygynous males of Akodon azarae (Rodentia: Sigmodontinae)  vary their mating tactics at low availability of females?","resumen":"&nbsp; Abstract:&nbsp;&nbsp;&nbsp; We examined in&nbsp;&nbsp; Akodon azarae&nbsp; if at low availability of females (sex ratio biased toward males, 3:1), the mating tactics of males are determined by the number of receptive females to which they have access, or by the number of male competitors with which they interact. To test these hypotheses, we measured the home range size and overlap degree. At the beginning of the reproductive season, we studied spacing patterns using 57 and 30 home ranges established by reproductive males and females in three enclosure populations. We statistically compared our results with those previously obtained in enclosure populations with a sex ratio of 1:1. Male home range sizes were larger than those recorded in populations with a sex ratio of 1:1. The degree of male intra-sexual overlap increased about 3.5 times with respect to that observed under a sex ratio of 1:1. The increase in home range sizes and intra-sexual overlap degree of reproductive males reflects that&nbsp;&nbsp; A. azarae&nbsp; males may adjust their spacing strategy to increase their mating opportunities at low density of females. Our results suggest that at low breeding female availability, male mating tactics could be determined by the number of receptive females to which they have access.&nbsp;","palabras_clave":"FEMALE AVAILABILITY|MATING TACTICS|REPRODUCTIVE SUCCESS|SIGMODONTINAE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19410,"idioma_id":5,"titulo":"Cómo se puede ahorrar energía con buen diseño","resumen":"En Argentina, aproximadamente un tercio del gasto energético total es consumido por edificios. El objetivo de esta nota de opinión es indagar sobre la valoración del -y consecuentemente la respuesta que se ofrece al-  consumo energético edilicio en la cultura arquitectónica local.","palabras_clave":"CONSUMO ENERGETICO|ENVOLVENTE EDILICIA|AISLACION TERMICA|ARQUITECTURA URBANA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19411,"idioma_id":4,"titulo":"Pushed to the limit: food abundance determines tag-induced harm in penguins","resumen":"The energetic costs of animal movement change with body condition, although the consequences of this for foraging efficiency are rarely considered. We deployed externally attached devices to Magellanic penguins (Spheniscus magellanicus), known to increase the costs of swimming via increased drag in a consistent manner, and noted, however, that foraging behaviour and efficiency varied dramatically between years. We used our results to construct an energetics-based model and found that small increases in drag due to the attachment of externally attached tags predicted accelerating harm as prey availability decreased, which accorded with our observations. This explains earlier observations of differential breeding success in tagged versus untagged penguins in particular years, highlights the importance of understanding how animal body condition may affect population processes in general and advocates caution in interpretations of tag-derived data over variable environmental conditions.","palabras_clave":"ANIMAL WELFARE|BODY CONDITION-DEPENDENT COST OF TRANSPORT|DRAG|ENERGY EXPENDITURE| MAGELLANIC PENGUIN|SPHENISCUS MAGELLANICUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19412,"idioma_id":5,"titulo":"Construcción y Sustentabilidad","resumen":"En laactualidad, es imposible pensar en el desarrollo de cualquier tipo de actividadsin la incorporación del concepto de sustentabilidad, que incluye laconsideración de las dimensiones económica, ambiental y social. Por lo tantotodo proyecto de construcción, para resultar sostenible, debe abordarlas. Integrar los aspectos de la sustentabilidad supone desarrollar acciones que van más allá del cumplimiento de las obligaciones legalmente vinculantes.En materia ambiental, enparticular, existe un marco normativo aplicable a la construcción.","palabras_clave":"NORMATIVA AMBIENTAL|SUSTENTABILIDAD |CONSTRUCCION|NORMATIVA VOLUNTARIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19413,"idioma_id":4,"titulo":"Geochemical processes regulating F&#8722;, as and NO3 &#8722; content in the groundwater of a sector of the Pampean Region, Argentina","resumen":"The presence of F&#8722; and As in groundwater is common in volcanic aquifers. Excessive concentrations of these ions affect the quality of drinkingwater and can be harmful to health.When there is an anthropogenic source in phreatic aquifers, NO3&#8722; is incorporated to the groundwater components, deteriorating its quality. The objective of this work is to assess the geochemical processes that regulate the contents of F&#8722;, As and NO3&#8722; of the groundwater in a sector of the Pampean Region in Argentina. This area is supplied with water by exploiting a multilayer aquifer, composed of a phreatic aquifer occurring in loess sediments and a fluvial semi-confined aquifer, separated by an aquitard. The results obtained show that the phreatic aquifer has a higher concentration of F&#8722;, As and NO3&#8722; than the semi-confined aquifer. Fluoride derives from the dissolution of volcanic glass at a slightly alkaline pH and from anion exchange; however, it may also be absorbed by the reprecipitating carbonates. The As is released by desorption, with the main source being the glass and lithic fragments of the loess. The NO3&#8722; originates from the decomposition of organic matter, mainly in the septic tanks of the peri-urban areas. Meanwhile, the As and F&#8722; content in the semi-confined aquifer is lower and its origin is the result of water inflow by vertical downward infiltration from the phreatic aquifer through the aquitard. The Pampean Region is one of the areaswith the largest volume of agricultural exports in the world and at present it is undergoing a strong social and economic growth. Understanding the geochemical processes that regulate the quality of drinking water is of vital importance to generate water management guidelines aiming at minimizing the deterioration of drinking water sources.","palabras_clave":"HYDROCHEMISTRY|WATER QUALITY|PAMPEAN PLAIN|MULTILAYER AQUIFER|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19414,"idioma_id":4,"titulo":"The Hydrolysis of Phenyl Trifluoroacetate in AOT\/N-Heptane RMs as a Sensor of the Encapsulated Water Structure","resumen":"A study was carried out on the hydrolysis of phenyl trifluoroacetate (PTFA) in AOT\/n-heptane\/water reversemicelles. The results obtained have been interpreted by taking into account the distribution of the PTFAusing a kinetic model based on the pseudophase model and, it is demonstrated that the reaction takesplace in the water pool of the reverse micelles. Moreover, it is established that the water moleculesinvolved in the hydration of the interface do not react with PTFA or they do it at much slower ratecompared with the water molecules that form the pool. The value of the second order rate constant inthe water pool, kw?MI, is of the same order of magnitude as that in pure water but is greater (500 times)than those obtained in water?acetonitrile mixtures with low water content. We performed kineticsolvent isotopic effect (KSIE) and proton inventory experiments (PI) and we concluded that the water isacting as a general-base catalyst and the water sequestered in the water pool is pre-organized favoringthe activation process, in contrast to what happened in water?acetonitrile mixtures.","palabras_clave":"micelle reverse"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19415,"idioma_id":4,"titulo":"Droplet Droplet Interactions investigated using a Combination of Electrochemical and Dynamic Light Scattering Techniques. The Case of Water\/BHDC\/Benzene:n-Heptane System","resumen":"In this contribution the electrochemistry of [Fe(CN)6]4-\/3- as the probe molecule was investigated in benzyl-n-hexadecyldimethylammonium chloride (BHDC) reverse micelles (RMs) varying the composition of the external solvent (benzene:n-heptane mixtures) and the surfactant concentration, at a fixed water content and probe concentration. The electrochemical and dynamic light scattering results show that in water\/BHDC\/benzene:n-heptane systems the aggregates sizes increase on increasing BHDC concentration.   This behavior was unexpected since it is known that for water\/BHDC\/benzene RMs systems keeping the water content constant and the surfactant concentration below 0.2 M, the droplet sizes are independent on the concentration of surfactant. We explain the results considering that changing the external solvent to benzene:n-heptane mixtures RMs tend to associate in clusters and, equilibrium between free RMs and droplet clusters is established. A model is presented which using electrochemical and dynamic light scattering data, allow calculating the aggregation number of the RMs, the number of RMs that forms the droplet clusters and the standard electron transfer heterogeneous rate constant.","palabras_clave":"REVERSE MICELLES|BHDC|MIXED SOLVENTS|MICELLES AGGREGATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19416,"idioma_id":5,"titulo":"Estudios bioarqueológicos en el sitio Los Tres Cerros 1 (Delta Superior del río Paraná, Entre Ríos, Argentina)","resumen":"En este trabajo se presentan los resultados de los estudiosbioarqueológicos efectuados en la serie de esqueletos humanos del sitio Los tres Cerros 1 (departamento de Victoria, Entre ríos,Argentina), una estructura antropogénica monticular ocupada entre ca. 1227 y560 años AP por cazadores, recolectores, pescadores y horticultores, asignadosa la entidadarqueológica Goya-Malabrigo. Las investigaciones bioarqueológicasse enfocaron en determinar la estructura sexo-etaria de la muestra,estudiar laslesiones óseas y analizar las prácticas mortuorias. de acuerdo a estosestudios, en el sitio se enterraron al menos 16 individuos de distintos gruposetarios y ambos sexos. La variabilidad de modos de disponer a los muertos incluye entierros primarios, secundarios yelementos óseos dispersos. Algunos huesos presentaban termoalteración y ocre sobre la superficie. se discuten estas evidenciasa nivel regional con otros sitios del delta del Paraná con presencia deesqueletos humanos asignados a la entidad Goya-Malabrigo. ","palabras_clave":"BIOARQUEOLOGÍA|PRACTICAS MORTUORIAS|PALEOPATOLOGIA|NORDESTE ARGENTINO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19417,"idioma_id":4,"titulo":"Incidence of Garlic common latent virus in Argentina, and phylogenetic and recombination analyses of isolates","resumen":"La Revista Pesquisa Agropecuaria Brasileira tiene por política no considerar que el Primer y Segundo autor contribuyeron de la misma manera, pero aceptaron esta modalidad haciendo referencia en la sección Agradecimiento.&nbsp;AcknowledgmentThe first and second authors contributed equally.The objective of this work was to estimate the incidence and prevalence of Garlic common latent virus (GarCLV) in the main production regions of garlic (Allium sativum) in Argentina, and to perform phylogenetic and recombination analyses in isolates from these regions. Leaf samples (3,050) were taken from four garlic commercial types, in 13 departments of the four main garlic&#8209;producing provinces of Argentina, in a 1,175 ha sampling area. Virus infection was evaluated with DAS&#8209;Elisa test using specific antiserum, and the phylogenetic and recombination analyses were done with capsid protein (CP) nucleotide sequence of seven GarCLV isolates from the provinces. The incidence of GarCLV in the evaluated provinces varied between 6.7 and 22% of the samples, whereas the prevalence varied between 52.6 and 70%. In the analysis of garlic commercial types, Morado showed the highest incidence of the virus, in the province of San Juan, whereas Rosado Paraguayo had the lowest incidence, in the province of Cordoba. Nucleotide identity in the CP sequences ranged between 80.3 and 97.6%. The phylogenetic analysis shows the presence of two main groups of GarCLV and of a possible third group that would include only a German isolate. The recombination analysis between isolates from different parts of the world evidences the presence of recombinant isolates from Poland and Australia.","palabras_clave":"ALLIUM SATIVUM|CARLAVIRUS|GarCLV|PREVALENCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19418,"idioma_id":4,"titulo":"Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain","resumen":"The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally","palabras_clave":"MDR OUTBREAK STRAINS|WHOLE GENOME SEQUENCING|EVOLUTION ANTIMICROBIAL RESISTANCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19419,"idioma_id":4,"titulo":"Tracking novel adenovirus in environmental and human clinical  samples: no evidence of endemic human adenovirus type 58 circulation in Córdoba city, Argentina","resumen":"In recent years, several types of human adenovirus (HAdV) have arisen from the recombination between two or more previously known HAdV types, but their epidemiology is poorly understood. In this study, we investigated the circulation of HAdV-58, a recently described HAdV isolated from an HIV-positive patient in Córdoba city, Argentina. For this purpose, a 30-month survey was conducted to study the presence of this type of adenovirus in sewage samples collected at the inlet from a wastewater treatment plant in Córdoba city, Argentina. Complementarily, the virus was sought in stools of HIV-positive patients. Although HAdVs were detected in human stool samples and in a high percentage of sewage samples, no evidence of HAdV-58 circulation was detected. We suggest that there is no endemic circulation of HAdV-58 in the geographical local area. The trend is that the number of identified HAdVs increases over time. In this context, understanding the current circulating HAdVs may be biologically relevant.","palabras_clave":"Circulation | human adenovirus|sewage"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19420,"idioma_id":4,"titulo":"Maintenance of picobirnavirus (PBV) infection in an adult orangutan (Pongo pygmaeus) and genetic diversity of excreted viral strains during a three-year period","resumen":"The present work provide data about the maintenance of picobirnavirus (PBV) infection during adulthood in a mammalian host. For this purpose PBV infection was studied in an adult orangutan (Pongo pygmaeus) by PAGE\/SS, RT-PCR and nucleotide sequencing. PBV infection in the animal was asymptomatic and was characterized by interspaced silent and high\/ low active viral excretion periods. The PBV strains excreted by the studied individual were identified as genogroup I and revealed a nucleotide identity among them of 64?81%.    The results obtained allowed to arrive to a deeper understanding of the natural history of PBV infection, which seems to be characterized by new-born, juvenile and adult asymptomatic hosts which persistently excrete closely related strains in their feces. Consequently, picobirnaviruses could be considered frequent inhabitants of the gastrointestinal tract, leaving the question open about the molecular mechanisms governing persistent and asymptomatic coexistence within the host and the potential host suitability to maintain this relationship.","palabras_clave":"PBV|Mammalian|genotypes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19421,"idioma_id":4,"titulo":"Leaf carbohydrate metabolism in Malbec grapevines: combined effects of regulated deficit irrigation and crop load strategies","resumen":"          Leaf  biomass results from the balance between net carbon assimilation by net  photosynthesis, storage, utilization, and carbohydrate export out of the leaf. Leaf  net photosynthesis and carbohydrate metabolism are affected by abiotic  stresses, making them a key target to be studied in the context of fluctuating  and constraining environments. In irrigated viticulture, Regulated Deficit Irrigation  (RDI) and crop load adjustment are widely applied practices to improve grape  and wine quality. However, there is limited knowledge about the effects of  combined RDI and crop regulation strategies on leaf carbohydrate metabolism (Aca  tiene que ser punto seguido, los abrastracs no llevan puntos apartes)In this  study we evaluated leaf photosynthesis, non-structural carbohydrates  accumulation and leaf carbon utilization during a day-night cycle of field  grown grapevines under different irrigation and crop load strategies. The study  was conducted during 2009-2010 season in a Malbec vineyard in Agrelo, Mendoza.  Two levels of water supply between fruitset and harvest (100% and 25% of  reference evapotranspiration ET0), and two crop loads at veraison (20  and 10 clusters per vine) were imposed on the vines. Diurnal dynamics of leaf  water potential, photosynthesis and carbohydrate concentration where determined  at bloom, veraison and harvest. Water deficit affected diurnal dynamics of leaf  water potential, gas exchanges and non-structural carbohydrates, while crop  load affected only leaf starch concentration at veraison. This study showed  that deficit irrigation affected leaf photosynthesis and leaf carbon metabolism  independently of crop load.   ","palabras_clave":"Regulated deficit irrrigation|cluster thinning|photosynthesis|soluble sugars|starch"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19422,"idioma_id":5,"titulo":"LA RENOVACIÓN AMBIENTAL DE LOS DESTINOS TURÍSTICOS. EL CASO DE NECOCHEA, BUENOS AIRES, ARGENTINA","resumen":"Actualmente, los destinos de sol y playa afrontan la necesidad de renovación y, en el Partido de Necochea, Argentina, se elaboró el Plan Estratégico de Turismo Sustentable de Necochea para responder a esta necesidad.  La  implementación requiere analizar y evaluar de modo pragmático y programático las intervenciones territoriales para alcanzar las estrategias definidas para el reposicionamiento.  El artículo se propone  identificar las unidades de gestión del espacio,  los modelos de intervención para un escenario estratégico que contribuya a la gestión sustentable y reorientación turística y proporcionar bases para la reestructuración territorial como eje transversal de política pública ambiental y turística. Para ello, respecto de las unidades se delimita el espacio turístico en función de las particularidades físico-espaciales, los recursos turísticos y oportunidades recreativas y las disfuncionalidades o problemáticas detectadas. Luego, se definen los contenidos concretos de los tipos de intervención propuestos que reorienten la renovación. Y por último, se enuncian las bases para las actuaciones de reestructuración territorial en función de un escenario estratégico. La renovación ambiental de Necochea debe basarse en estrategias conducentes a la cualificación del espacio turístico, la diferenciación basada en la naturaleza, la potenciación del entorno urbano y la inclusión de lo ambiental en la gestión turística.","palabras_clave":"renovación ambiental|Necochea|desarrollo turístico sustentable|planificación estratégica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19423,"idioma_id":4,"titulo":"In-hospital mortality risk factors in community acquired pneumonia: evaluation of immunocompetent adult patients without comorbidities","resumen":"Introduction: several scores were developed in order to improve the determination of community acquired pneumonia (CAP) severity and its management, mainly CURB-65 and SACP score. However, none of them were evaluated for risk assessment of in-hospital mortality, particularly in individuals who were non-immunosuppressed and\/or without any comorbidity. In this regard, the present study was carried out.Material and methods: we performed a cross-sectional study in 272 immunocompetent patients without comorbidities and with a diagnosis of CAP. Performance of CURB-65 and SCAP scores in predicting in-hospital mortality was evaluated.Also, variables related to death were assessed. Furthermore, in order to design a model of in-hospital mortality prediction, sampled individuals were randomly divided in two groups. The association of the variables with mortality was weighed and, by multiple binary regression, a model was constructed in one of the subgroups. Then, it was validated in the other subgroup.Results: both scores yielded a fair strength of agreement, and CURB-65 showed a better performance in predicting in-hospital mortality. In our casuistry, age, white blood cell counts, serum urea and diastolic blood pressure were related to death. The model constructed with these variables showed a good performance in predicting in-hospital mortality; moreover, only one patient with fatal outcome was not correctly classified in the group where the model was constructed and in the group where it was validated.Conclusion: our findings suggest that a simple model that uses only 4 variables, which are easily accessible and interpretable, can identify seriously ill patients with CAP.","palabras_clave":"PNEUMONIA|IN HOSPITAL MORTALITY|RISK FACTOR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19424,"idioma_id":4,"titulo":"Prethermalization and glassiness in the bosonic Hubbard model","resumen":"We investigate the nonequilibrium dynamics of the bosonic Hubbard model starting from inhomogeneous superfluid or Mott insulator initial states using the truncated Wigner approximation (TWA). We find that the relaxation of the system develops in two steps for sufficiently large interaction strengths: after a fast relaxation the system gets caught in metastable prethermalized states that precede the true equilibrium state. We find that the lifetime of these prethermalized states increases by several orders of magnitude as we increase the on-site interaction strength beyond a threshold value. We show that the emergence of long-lived metastable states in the quantum dynamics is associated with an ergodic (active) to nonergodic (inactive) dynamical phase transition in the ensemble of classical trajectories that contribute to the semiclassical limit. This dynamical phase transition, which is very similar to that found in different classical models of glasses, is closely related to the dynamic heterogeneity of the classical relaxation.","palabras_clave":"PRETHERMALIZATION|HUBBARD|MODEL|GLASSINESS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19425,"idioma_id":4,"titulo":"Isotopic Evidence of Weaning in Hunter-gatherers from the Late Holocene in Lake Salitroso, Patagonia, Argentina","resumen":"Objectives:  The timing and duration of breastfeeding and weaning in past hunter-gatherer populations are discussed based on the results of stable carbon and nitrogen isotope analyses undertaken on a Late Holocene skeletal sample from Lake Salitroso in the Patagonian steppe (Argentina). Research in Lake Salitroso is part of a regional project that studies the Relationship between hunter-gatherer societies, their organizational systems and the environmental changes during the last 3,000 years in Patagonia.  Methods:  The sample included 52 individuals: 33 subadults and 19 adults of both sexes. They were recovered from 24 burial stone structures -locally called chenques-, with dates ranging from ca. 800 BP to 350 BP. Ribs were selected for collagen extraction and measurement of 13C\/12C and 15N\/14N ratios.  Results:  A 13C mean value of -18.7 ± 0.5 was obtained, with a range between -19.8 and -17.1 whereas 15N recorded a mean of 11.9 ± 1.1 with a range between 10.1 and 14.8. 15N data showed an age-related pattern with particularly marked difference between values for subadults under the age of 4 and older individuals. As opposed to 15N, 13C showed little variation with age.  Conclusions:  An early incorporation of supplementary solid food between 0.75 and 2 years of age and a late cessation of breastfeeding at about 5 to 6 years of age were inferred. This suggests that among this Patagonian hunter-gatherer population weaning was a gradual and lengthy process. These  results are consistent with the patterns observed in cross-cultural studies and archaeological samples of hunter-gatherer groups.","palabras_clave":"BREASTFEEDING|STABLE ISOTOPES ANALYSIS|COLLAGEN|PATAGONIA|HUNTER-GATHERERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19426,"idioma_id":4,"titulo":"Molecular aspects of intestinal calcium absorption","resumen":"The intestinal Ca2+ absorption occurs through transcellular and paracellular pathways. Apparently, novel proteins such as Cav1.3 and 4.1R protein are involved in the Ca2+ transcellular pathway. Proteins involved in the tight junction structures such as Claudins 2, 12 and 15 participate in the paracellular pathway. There is evidence of a crosstalk between the transcellular and the paracellular pathways. To know the molecular details of the intestinal Ca2+ absorption could lead to develop nutritional and medical strategies to optimize the efficiency of intestinal Ca2+ absorption and to prevent osteoporosis and other pathologies related to Ca2+ metabolism.","palabras_clave":"INTESTINAL ABSOPRTION|CALCIUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19427,"idioma_id":4,"titulo":"An efficient and accurate implementation of the Localized Regular Dual Reciprocity Method","resumen":"In this work we present an efficient and accurate implementation of the LRDRM. This integral domain decomposition method exploits two advantages: first, it imposes the boundaryconditions at the Local RBF interpolation. Second, the integrals to compute are always regular. The approximation of the derivative of the field variable is computed in a posterioriway, directly differentiating the Local RBF interpolation or the local integral equation. Theefficient and accurate behaviour of this method are demonstrated by performing numericalexamples, with special emphasis on a 1D benchmark convective-diffusion equation. Resultsfor 2D convection?diffusion, 2D Helmholtz and 2D Poisson equations are also presented.","palabras_clave":"Dual Reciprocity Method|Radial Basis Functions|Meshless Methods"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19428,"idioma_id":4,"titulo":"Galaxy triplets in Sloan Digital Sky Survey Data Release 7 - III. Analysis of configuration and dynamics","resumen":"We analyse the spatial configuration and the dynamical properties of a sample of 92 galaxy triplets obtained from the Data Release 7 of Sloan Digital Sky Survey (SDSS-DR7; SDSS-triplets) restricted to have members with spectroscopic redshifts in the range 0.01 &#8804; z &#8804; 0.14 and absolute r-band luminosities brighter than Mr = -20.5. The configuration analysis was performed through Agekyan & Anosova map (AA-map). We estimated dynamical parameters, namely the radius of the system, the velocity dispersion, a dimensionless crossing-time and the virial mass. We compared our results with those obtained for a sample of triplets from the catalogue `Isolated Triplets of Galaxies´ (K-triplets) and a sample of Compact Groups. We have also studied a mock catalogue in order to compare real and projected configurations, and to estimate the three-dimensional dynamical parameters of the triple systems. We found that the SDSS-triplets prefer alignment configurations while K-triplets present a uniform distribution in the AA-map. From the dynamical analysis we conclude that the SDSS-triplets, K-triplets and Compact Groups present a similar behaviour comprising compact systems with low crossing-time values, with velocity dispersions and virial masses similar to those of low-mass loose groups. Moreover, we found that observed and simulated triplets present similar dynamical parameters. We also performed an analysis of the dark matter content of galaxy triplets finding that member galaxies of mock triplets belong to the same dark matter halo, showing a dynamical co-evolution of the system. These results suggest that the configuration and dynamics of triple systems favour galaxy interactions and mergers.","palabras_clave":"GALAXY|SLOAN|SURVEY|DYNAMICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19429,"idioma_id":4,"titulo":"Clues on void evolution - III. Structure and dynamics in void shells","resumen":"Inspired on the well known dynamical dichotomy predicted in voids, where some underdense regions expand whereas others collapse due to overdense surrounding regions, we explored the interplay between the void inner dynamics and its large scale environment. The environment is classified depending on its density as in previous works. We analyse the dynamical properties of void-centered spherical shells at different void-centric distances depending on this classification. The above dynamical properties are given by the angular distribution of the radial velocity field, its smoothness, the field dependence on the tracer density and shape, and the field departures from linear theory. We found that the velocity field in expanding voids follows more closely the linear prediction, with a more smooth velocity field. However when using velocity tracers with large densities such deviations increase. Voids with sizes around 18h&#8722;1 Mpc are in a transition regime between regions with expansion overpredicted and underpredicted from linear theory. We also found that velocity smoothness increases as the void radius, indicating the laminar flow dominates the expansion of larger voids (more than 18h&#8722;1 Mpc). The correlations observed suggest that nonlinear dynamics of the inner regions of voids could be dependent on the evolution of the surrounding structures. These also indicate possible scale couplings between the void inner expansion and the large scale regions where voids are embedded. These results shed some light to the origin of nonlinearities in voids, going beyond the fact that voids just quickly becomes nonlinear as they become emptier.","palabras_clave":"LARGE-SCALE STRUCTURE OF THE UNIVERSE|METHODS: NUMERICAL|METHODS: STATISTICAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19430,"idioma_id":4,"titulo":"Brightest group galaxies and the large-scale environment","resumen":"We study the population of galaxies in groups and the dependence of their statistical properties on the surrounding large?scale environment, using SDSS-DR7 data. Galaxies are ranked according to luminosity within each group and classified morphologically by the Sérsic index. We have considered two different samples taking into account if the host groups reside in superstructures or elsewhere. We find a significant dependence of the properties of late?type brightest group galaxies on the large?scale environment. The other member galaxies exhibit only the influence of the group they inhabit. Late?type brightest galaxies show statistically significant higher luminosities and stellar masses, redder u-r colours, lower star formation activity and larger star?formation time?scale when embedded in superstructures. By contrast, the properties of the early?type brightest group galaxy are remarkably similar regardless of the group global environment. Our analysis comprises tests against the dependence on the host group luminosity and we argue that group brightest member properties are not only deter-  mined by the host halo, but also by the large?scale structure which can influence the accretion process onto their late?type brightest galaxies.","palabras_clave":"LARGE-SCALE STRUCTURE OF THE UNIVERSE|STATISTICS|DATA ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19431,"idioma_id":4,"titulo":"GH\/STAT5 signaling during the growth period in livers of mice overexpressing GH","resumen":"GH\/STAT5 signaling is desensitized in the liver in adult transgenic mice overexpressing GH; however, these animals present greater body size. To assess whether the STAT5 pathway is active during the growth period in the liver in these animals, and how signaling modulators participate in this process, growing transgenic mice and normal siblings were evaluated.STAT5 does not respond to an acute GH-stimulus, but displays higher basal phosphorylation in the livers of growing GH-overexpressing mice. GH receptor and the positive modulators glucocorticoid receptor and HNF1 display greater abundance in transgenic animals, supporting the activity of STAT5. The negative modulators cytokine-induced suppressor and PTP1B are increased in GH-overexpressing mice. The suppressors SOCS2 and SOCS3 exhibit higher mRNA levels in transgenic mice but lower protein content, indicating that they are being actively degraded. Therefore, STAT5 signaling is increased in the liver in GH-transgenic mice during the growth period, with a balance between positive and negative effectorsresulting in accelerated but controlled growth.","palabras_clave":"GROWTH HORMONE|LIVER|STAT|DEVELOPMENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19432,"idioma_id":4,"titulo":"Pituitary and Brain Dopamine D2 Receptors Regulate Liver Gene Sexual Dimorphism","resumen":"Liver sexual gene dimorphism, which depends mainly on specific patterns of GH secretion, may underlie differential susceptibility to some liver diseases. Because GH and prolactin secretion are regulated by dopaminergic pathways, we studied the participation of brain and lactotrope dopamine 2 receptors (D2Rs) on liver gene sexual dimorphism, to explore a link between the brain and liver gene expression. We used global D2R knockout mice (Drd2\/) and conducted a functional dissection strategy based on cell-specific Drd2 inactivation in neurons (neuroDrd2KO) or pituitary lactotropes. Disruption of neuronal D2Rs (which impaired the GH axis) decreased most of male or female-predominant class I liver genes and increased female?predominant class II genesin males, consistent with the positive (class I) or negative (class II) regulation of these genes by GH. Notably, sexual dimorphism was lost for class I and II genes in neuroDrd2KO mice. Disruption of lactotrope D2Rs did not modify class I or II genes in either sex, because GH axis was preserved. But surprisingly, 1 class II gene (Prlr) and female-predominant class I genes were markedly up-regulated in lacDrd2KO females, pointing to direct or indirect effects of prolactin in the regulation of selected female-predominant liver genes. This suggestion was strengthened in the hyperprolactinemic Drd2\/ female mouse, in which increased expression of the same 4 liver genes was observed, despite a decreased GH axis. We hereby demonstrate endocrine-mediated D2R actions on sexual dimorphic liver gene expression, which may be relevant during chronic dopaminergic medications in psychiatric disease.","palabras_clave":"DOPAMINE RECEPTOR|LIVER|CYPS|GH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19433,"idioma_id":4,"titulo":"Effect of Mg2+ binding on transmission of bovine serum albumin (BSA) through ultrafiltration membranes","resumen":"Protein fractionation by membrane technology has many advantages for separations, in comparison with conventional methods. In this paper, the influence of different type and concentration of two electrolytes: NaCl and MgCl2 on buffer capacity and hydrodynamic radius of bovine plasma proteins were analyzed as a way to improve protein separation by cross-flow ultrafiltration. A tubular ceramic membrane with 0.2 &#956;m pore size was used. The evolution of permeate flux and BSA transmission was determined at 25 °C and transmembrane pressure range of 0.2?1.4 bar. The membrane fouling was evaluated through the resistance model application, identifying the operational conditions of the highest BSA transmission through the membrane. In this regard, it was demonstrated that the effective radius of the protein and its buffering capacity were affected by the use of MgCl2 at 0.006 (w\/v), which caused conformation changes in the protein structure resulting in a less resistance to transport.","palabras_clave":"ultrafiltration, |BSA,| transmission"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19434,"idioma_id":4,"titulo":"Expression and function of AtMBD4L, the single gene encoding thenuclear DNA glycosylase MBD4L in Arabidopsis","resumen":"DNA glycosylases recognize and excise damaged or incorrect bases from DNA initiating the base excisionrepair (BER) pathway. Methyl-binding domain protein 4 (MBD4) is a member of the HhH-GPD DNAglycosylase superfamily, which has been well studied in mammals but not in plants. Our knowledge onthe plant enzyme is limited to the activity of the Arabidopsis recombinant protein MBD4L in vitro. Tostart evaluating MBD4L in its biological context, we here characterized the structure, expression andeffects of its gene, AtMBD4L. Phylogenetic analysis indicated that AtMBD4L belongs to one of the sevenfamilies of HhH-GPD DNA glycosylase genes existing in plants, and is unique on its family. Two AtMBD4Ltranscripts coding for active enzymes were detected in leaves and flowers. Transgenic plants expressingthe AtMBD4L:GUS gene confined GUS activity to perivascular leaf tissues (usually adjacent to hydathodes),flowers (anthers at particular stages of development), and the apex of immature siliques. MBD4L-GFPfusion proteins showed nuclear localization in planta. Interestingly, overexpression of the full lengthMBD4L, but not a truncated enzyme lacking the DNA glycosylase domain, induced the BER gene LIG1 andenhanced tolerance to oxidative stress. These results suggest that endogenous MBD4L acts on particulartissues, is capable of activating BER, and may contribute to repair DNA damage caused by oxidative stress.","palabras_clave":"DNA glicosidasas|MBD4|Arabidopsis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19435,"idioma_id":4,"titulo":"Nickel, lead and zinc accumulation and performance in relation to their use in phytoremediation of macrophytes Myriophyllum aquaticum and Egeria densa","resumen":"In order to study the accumulation of nickel, lead and zinc for their use in the phytoremediation of aquatic environments, the aquatic plants Myriophyllum aquaticum and Egeria densa were exposed to increase the concentrations of these metals (Ni: 0.05?10 mg L1, Pb: 0.05?15 mg L1, Zn: 0.15?20 mg L1) for 7 days.The accumulation of Ni, Pb and Zn in plants was determined and their effects on physiological parameters (chlorophyll a concentration and degradation, lipid peroxidation measured as malondialdehyde) were evaluated in the leaves for both species. M. aquaticum showed a higher accumulation capacity of Pb andZn than E. densa, particularly at the highest concentrations of exposure to these metals. Nevertheless, the physiological changes observed in these species, especially in M. aquaticum, at high metal concentrations and accumulations, did not represent a risk in relation to their survival during the study period.Therefore, taking into account their accumulation capacity and tolerance to heavy metals, M. aquaticum is more suitable for phytoremediation in aquatic environmental contaminated with Ni, Pb or Zn than E.densa.","palabras_clave":"Heavy metals|Phytoextraction|Macrophytes|Myriophyllum aquaticum|Egeria densa|Physiological parameters"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19436,"idioma_id":4,"titulo":"5-HT3 Receptor Brain-Type B-Subunits are Differentially Expressed in Heterologous Systems","resumen":"Genes for five different 5-HT3 receptor subunits have been identified.   Most of the subunits have multiple isoforms, but two isoforms of the B subunits, Brain-type1 (Br1) and Brain-type 2 (Br2) are of particular interest as they appear to be abundantly expressed in human brain, where 5-HT3B subunit RNA consists of approximately 75% 5-HT3Br2, 24% 5-HT3Br1 and <1%5-HT3B. Here we use two-electrode voltage-clamp, radioligand binding, fluorescence, whole cell and single channel patch-clamp studies to characterize the roles of 5-HT3Br1 and 5-HT3Br2 subunits on function and pharmacology in heterologously expressed 5-HT3 receptors. The data show that the 5-HT3Br1 transcriptional variant, when co-expressed with 5-HT3A subunits, alters the EC50, nH and single channel conductance of the 5-HT3 receptor, but has no effect on the potency of competitive antagonists, similar to data obtained with the 5-HT3B subunit. Conversely the 5-HT3Br2 subunit does not appear to form functional channels with the 5-HT3A subunit in either oocytes or HEK293 cells.  As the 5-HT3Br1 subunit is functional, we can conclude that it is likely to be an important component in brain 5-HT3 receptor signalling. The role of the 5HT3Br2 subunit is yet to be determined.","palabras_clave":"SEROTONIN RECEPTOR|PATCH CLAMP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19437,"idioma_id":4,"titulo":"Photodynamic Action Mechanism Mediated by of Zinc(II) 2,9,16,23-Tetrakis[4-(N-methylpyridyloxy)]phthalocyanine in Candida albicans Cells","resumen":"The photoreaction type I\/type II pathways mediated by zinc(II)2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]phthalocyanine(ZnPPc4+) was studied in Candidaalbicans cells. This photosensitizer was strongly boundto C. albicans cells at short times. After 30 min irradiation, 5 mM ZnPPc4+ produced ~5 log decrease ofcell viability. Different probes were used to detect reactive oxygen species(ROS) in cell suspensions (~106 CFU\/mL). Singlet molecular oxygen, O2(1Dg), was observed by the reaction with 9,10-dimethylanthracene(DMA) and tetrasodium 2,2-(anthracene-9,10-diyl)bis(methylmalonate) (ABMM),while the nitro blue tetrazolium (NBT) method was used to sense superoxideanion radical (O2.-). Moreover,the effects produced by an anoxic atmosphere and cell suspensions in D2O,as well as the addition of sodium azide and mannitol as ROS trapping were evaluatedin the PDI of C. albicans. These investigationindicates that O2(1Dg) isgenerated in the cells, although a minor extension other radical species canalso be involved in the PDI of C.albicans mediated by ZnPPc4+.","palabras_clave":"PHTHALOCYANINE|PHOTOINACTIVATION|ROS|PHOTODYNAMIC MECHANISM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19438,"idioma_id":4,"titulo":"Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons","resumen":"Thalamocortical neurons are involved in the generation and maintenance of brain rhythms associated with global functional states. The repetitive burst firing of TC neurons at delta frequencies (1?4 Hz) has been linked to the oscillations recorded during deep sleep and during episodes of absence seizures. To get insight into the biophysical properties that are the basis for intrinsic delta oscillations in these neurons, we performed a bifurcation analysis of a minimal conductance-based thalamocortical neuron model including only the IT channel and the sodium and potassium leak channels. This analysis unveils the dynamics of repetitive burst firing of TC neurons, and describes how the interplay between the amplifying variable mT and the recovering variable hT of the calcium channel IT is sufficient to generate low threshold oscillations in the delta band. We also explored the role of the hyperpolarization activated cationic current Ih in this reduced model and determine that, albeit not required, Ih amplifies and stabilizes the oscillation.","palabras_clave":"Thalamocortical Neuron|Subthreshold conductances|T-type calcium channel"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19439,"idioma_id":4,"titulo":"Anchored in 'average thinking' in studies of arid rangeland dynamics - The need for a step forward from traditional measures of variability","resumen":"There is a wide consensus that arid and semi-arid environments are   highly variable in space and time. The most frequent approaches to   describe and analyze arid and semi-arid rangelands are based on the   usage of averages and Normal distributions as main references to   describe spatial and temporal differences. We argue that rangeland   ecology science should move forward in methods to better capture the   patterns of rangeland dynamics, rather than just focusing on simple   measures of variability. We provide different simulated time series data   in order to illustrate the limitations of some currently used   methodologies. We call for the application of time series methods in   order to better understand complex dynamics in arid and semi-arid   rangelands.","palabras_clave":"Coefficient of variation|Fourier|Rangeland ecology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19440,"idioma_id":4,"titulo":"A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz: Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line","resumen":"&nbsp;&nbsp;&nbsp;&nbsp; Theoxidovanadium(IV) complex of oxodiacetic acid (H2ODA) and dppz (dipyrido[3,2-a:2?,3?-c] phenazine) of stoichiometry [VO(ODA)(dppz)]×3H2O could be synthesized for the first time by reactionbetween [VO(ODA)(H2O)2] and dppz. It was characterized byinfrared and electronic spectroscopies. Its optimized molecular structure wasobtained by DFT calculations, as it was impossible to grow single crystalsadequate for crystallographic studies. The antitumor action of the complex onMG-63 human osteosarcoma cell line was also investigated. It was found that itcaused a concentration related inhibitory effect in the concentration rangebetween 5 and 25 mM and diminishedthe cell viability ca. 45% in the range from 25 to 100 &#956;M, withoutdose\/response effects in this range. These biological effects are, in general,similar to those previously reported for the related [VO(ODA)(ophen)]×1.5H2O complex.","palabras_clave":"OXIDOVANADIUM(IV)|OXODIACETIC ACID\/DPPZ|DFT-CALCULATIONS|FTIR and ELECTRONIC SPECTRA|HUMAN OSTEOSARCOMA CELL LINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19441,"idioma_id":4,"titulo":"Adjustment of a rapid method for quantification of Fusarium spp. spore suspensions in plant pathology","resumen":"The use of a Neubauer chamber is a broadly employed method when cell suspensions need to be quantified. However, this technique may take a long time and needs trained personnel. Spectrophotometry has proved to be a rapid, simple and accurate method to estimate the concentration of spore suspensions of isolates of the genus Fusarium. In this work we present a linear formula to relate absorbance measurements at 530 nm with the number of microconidia\/ml in a suspension.","palabras_clave":"Spectrophotometry|Spore counting|Laboratory methods"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19442,"idioma_id":4,"titulo":"Chlorophyll fluorescence and lipid peroxidation changes in rice somaclonal lines subjected to salt stress","resumen":"              The aim of the  present work was to explore physiological changes provoked by somaclonal variation  in response to salinity. Two parental cultivars (La Candelaria and Yerua) and  their derived somaclones   were used as a  source for breeding new rice lines with improved salt tolerance.  We studied the effect of NaCl salt stress on  chlorophyll fluorescence-related parameters, such as the maximum quantum yield  of primary PSII photochemistry (Fv\/Fm) and the performance index for energy  conservation from photon absorbed by PSII antenna (PIABS). In addition malondiahldehyde  (MDA) content and leaf temperature (LT) responses were also measured. In  somaclonal lines, Fv\/Fm, PIABS, MDA and LT showed coefficients of variation of  13,7%, 39,3%, 25,5%, and 3 % respectively for La Candelaria and 1,4%, 17,6%, 34,4%  and 3% for  Yerua.  However, the   fragrant character did not differ in the   aromatic somaclonal lines with respect to their  parentals.   Our results suggest that the Fv\/Fm ratio would not be as good marker of  PSII vitality as PIABS for salinized rice somaclones, unless they are highly  susceptible to salinity.  On other hand,  the MDA content showed a strong negative correlation with the PIABS content in  somaclones of both rice cultivars, suggesting that MDA levels could also be  used as an oxidative damage index in rice somaclones.    ","palabras_clave":"CALLUS RICE|SOMACLONES|SALINITY|MALONDIALDEHIDO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19443,"idioma_id":4,"titulo":"An unusual theropod frontal from the Upper Cretaceous of north Patagonia","resumen":"We report an isolated left frontal (MCF-PVPH 320) corresponding to a medium-sized theropod dinosaur from the Portezuelo Formation (Coniacian)of northern Patagonia. It shows a unique combination of traits that are not present in any other known Cretaceous theropod from South America. MCF-PVPH 320 is robust and anteroposteriorly short, with a flat and smooth dorsal surface largely excavated by the supratemporal fossa. Endocranially, the olfactory bulb impression is elongate, and the olfactory tract impression is markedly shortened anteroposteriorly. MCF-PVPH 320 differsgreatly from the frontals of Late Cretaceous theropods, such as abelisaurids, megaraptorines and carcharodontosaurids. In contrast, character states including the thickness of the bone, V-shaped frontoparietal suture, reduced participation on the orbital margin and markedly short olfactory tract impression suggest the presence of an unknown mid-sized to large allosauroid for the Portezuelo Formation.","palabras_clave":"frontal|skull roof|theropod|Conianian"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19444,"idioma_id":4,"titulo":"Ecological Diversity in South American Mammals: Their Geographical Distribution Shows Variable Associations with Phylogenetic Diversity and Does Not Follow the Latitudinal Richness Gradient","resumen":"The extent to which the latitudinal gradient in species richness may be paralleled by a similar gradient of increasing functional or phylogenetic diversity is a matter of controversy. We evaluated whether taxonomic richness (TR) is informative in terms of ecological diversity (ED, an approximation to functional diversity) and phylogenetic diversity (AvPD) using data on 531 mammal species representing South American old autochthonous (marsupials, xenarthrans), mid-Cenozoic immigrants (hystricognaths, primates) and newcomers (carnivorans,artiodactyls). If closely related species are ecologically more similar than distantly related species, AvPD will be a strong predictor of ED; however, lower ED than predicted from AvPD may be due to species retaining most of their ancestral characters, suggesting niche conservatism. This pattern could occur in tropical rainforests for taxa of tropical affinity (old autochthonous and mid-Cenozoic immigrants) and in open and arid habitats for newcomers. In contrast, higher ED than expected from AvPD could occur, possibly in association withniche evolution, in arid and open habitats for taxa of tropical affinity and in forested habitats for newcomers. We found that TR was a poor predictor of ED and AvPD. After controlling for TR, there was considerable variability in the extent to which AvPD accounted for ED. Taxa of tropical affinity did not support the prediction of ED deficit within tropical rainforests, rather, they showed a mosaic of regions with an excess of ED interspersed with zones of ED deficitwithin the tropics; newcomers showed ED deficit in arid and open regions. Some taxa of tropical affinity showed excess of ED in tropical desert areas (hystricognaths) or temperate semideserts (xenarthrans); newcomers showed excess of ED at cold-temperate latitudes in the Northern Hemisphere. This result suggests that extreme climatic conditions at both temperate and tropical latitudes may have promoted niche evolution in mammals.","palabras_clave":"ecological diversity|phylogenetic diversity|species richness|South American mammals"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19445,"idioma_id":4,"titulo":"Heavy metals and trace elements in muscle of Silverside (Odontesthes bonariensis) and water from different environments (Argentina): Aquatic pollution and consumption effect approach","resumen":"The concentrations of As, Ag, B, Ba, Bi, Ca, Cd, Co, Cr, Fe, Ga, Hg, K, Li, Mg, Mn, Mo, Na, Ni, Pb, Rb, Sb, Se, Sn, Sr, Te, Ti, U, V and Zn were determined in water and silverside (Odontesthes bonariensis) muscle samples from four important commercial fishing sites (Argentina) by ICPMS. Trace element concentrations in water with well-documented human health effects were above the recommended maximum levels established by Argentinean and international guidelines for the aquatic biota protection in three sampling sites (e.g. As: 28.4-367&nbsp;g&nbsp;L&#8722;&nbsp;1; Cd: 0.17-1.05&nbsp;g&nbsp;L&#8722;&nbsp;1; Hg: 0.07-0.63&nbsp;g&nbsp;L&#8722;&nbsp;1; Zn: 71.3-90.0&nbsp;g&nbsp;L&#8722;&nbsp;1). High concentrations of As, Hg and Pb (0.03-0.76; 0.03-0.42 and 0.04-0.19&nbsp;mg&nbsp;kg&#8722;&nbsp;1 wet weight, respectively) were found in silverside muscle. Fishing communities associated with contaminated environments are likely to have higher consumption rates and are thus more likely to be exposed to higher concentrations of the toxic elements (As, Hg and Pb).","palabras_clave":"arsenic|mercury|lead|fish"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19446,"idioma_id":4,"titulo":"Isolation of herpes simplex virus type 2 attenuated variants using  carrageenans as selection agents","resumen":"Natural polysaccharides known as carrageenans (CGNs) are well known to be potent and selective inhibitors of Herpes simplex virus (HSV) by blocking the interaction of the virus with the cellular receptor. In this work, we used CGNs &#954; and &#953; as a selective pressure to obtain variants of herpes simplex type 2 by passaging the virus in vitro in the presence of increasing amounts of each CGN. At passage 22, four clones were selected for further characterization: &#953;22-9, &#953;22-12, &#954;22-12 and &#954;22-13. They showed a syncytial phenotype, grew at similar titers when compared to parental virus and exhibited moderate resistance to carrageenans. Syn phenotype may be ascribed to alterations at the level of glycoproteins B and K. Also, a mutation in the Thymidine kinase gene in the case of &#954;22-13 (aa 149 Val to Ala)  and in the DNA polymerase (pol) gene in the case of &#953;22-12 (aa 789 Met to Thr, in the conserved region VI), were detected. For k22-12, three substitutions in the DNA pol gene were identified: two in the conserved  region IV (Exo II), and one in a non-conserved gene region. Variants were less virulent than parental strain when tested in a mouse model inoculated either intravaginally or intranasally. Attenuation correlated with higher levels of IL-6 and TNF-a detected in animals inoculated with the variants.","palabras_clave":"ATTENUATION|HERPES|MUTATION|POLYSACCHARIDES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19447,"idioma_id":4,"titulo":"Potential of UV-C Light for Preservation of Cut Apples Fortified  with Calcium: Assessment of Optical and Rheological Properties and Native Flora Dynamics.","resumen":"The use of UV-C light (fluence 11.2 kJ\/m2) to preserve calcium fortified cut apples was investigated. Impregnation treatments with calcium salts at atmospheric pressure (AI) (with and without previous blanching (B)) were performed to incorporate calcium into the apple matrix. An antibrowning dipping (AD) (ascorbic acid\/calcium chloride solution) was also applied to non-blanched fortified apples. The impact of treatments on surface color, viscoelastic properties, microstructure, and native flora during refrigerated storage was analyzed. UV-C light was useful not only reducing microbial load of calcium-enriched apples (between 1.3 log cycles to non-detectable levels) but decreasing microorganisms? growth (between 0.7 to 2.6 log cycles as compared with apples without UV-C exposure) during 7-day storage at 5 °C. AI caused marked browning, and not significant additional color changes due to UV-C exposure were observed. Blanching not only facilitated calcium incorporation (four times higher than in non-blanched tissues) inside the fruit but also helped in reducing browning. AD was also effective to minimize color changes but diminished the UV-C germicidal effect. AD + AI and B + AI treatments negatively affected viscoelastic properties, being the changes more pronounced in heated tissues. Both storage and loss moduli were reduced due to processing and during storage of samples, indicating that fortified apple tissues became less elastic and less viscous. However, exposure of AD + AI and B + AI apples to UV-C did not modify creep response neither at  0 day nor at day 7 and also had a negligible effect on dynamic spectra. Modifications in rheological properties and color were partially ascribed to microstructure features (breakage of cellular membranes with loss of functional cell compartmentalization and loss of turgor; modifications in cell walls). These findings suggest thatUV-C irradiation could be used for prolonging shelf life of calcium fortified cut apples with minimal or negligible impact on color and viscoelastic properties.","palabras_clave":"UV-C LIGHT|CALCIUM IMPREGNATION|COLOR AND VISCOELASTIC PROPERTIES|NATIVE FLORA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19448,"idioma_id":4,"titulo":"Aryloxyethyl Thiocyanates are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii","resumen":"As a part of our project aimed at searching for new safe chemotherapeutic agents against parasitic diseases, several compounds structurally related to the antiparasitic agent WC-9 (4-phenoxyphenoxyethyl thiocyanate), which were modified at the terminal phenyl ring, were designed, synthesized, and evaluated as growth inhibitors against Trypanosoma cruzi, the etiological agent of Chagas disease, and Toxoplasma gondii, the parasite responsible of toxoplasmosis. Most of the synthetic analogues exhibited similar antiparasitic activity and were slightly more potent than our lead WC-9. For example, two trifluoromethylated derivatives exhibited ED50 values of 10.0 and 9.2&#8197;&#956;M against intracellular T.&#8197;cruzi, whereas they showed potent action against tachyzoites of T.&#8197;gondii (ED50 values of 1.6 and 1.9&#8197;&#956;M against T.&#8197;gondii). In addition, analogues of WC-9 in which the terminal aryl group is in the meta position with respect to the alkyl chain bearing the thiocyanate group showed potent inhibitory action against both T.&#8197;cruzi and T.&#8197;gondii at the very low micromolar range, which suggests that a para-phenyl substitution pattern is not necessary for biological activity.","palabras_clave":"Thyocianates|Trypanosoma|Toxoplasma"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19449,"idioma_id":4,"titulo":"Solid phase extraction\/cyclodextrin-modified micellar electrokinetic chromatography for the analysis of melatonin and related indole compounds in plants","resumen":"The identification of melatonin in plants has inspired new investigations to understand its biological function. Inthis work, a robust, reliable, low-cost, quick and simple method based on solid phase extraction followed bymicellar electrokinetic chromatography for the extraction, preconcentration and simultaneous determinationof melatonin, tryptophan, serotonin and indole-3-acetic acid in plant material is proposed. Extraction of indolecompounds from plant tissues was enhanced by ultrasound and solid phase extraction, which was carried outwith C8 SPE cartridges. The use of a dual pseudostationary phase system, involving a mixture of SDS anionicmicelles and â-cyclodextrin, enabled to reach adequate selectivity. A BGE of 10 mM sodium tetraborate(pH 9.2), containing 20 mM â-CD, 20 mM SDS, and 10% (v\/v) of acetonitrile, allowed baseline separation inless than 10 min. The proposed methodology provided limits of detection (LODs) down to low ppb levels.Under the optimal conditions, a successful application on Arabidopsis tissue, green, and linden tea leavesconfirmed the validity of this method for food analysis and as a tool to contribute to the elucidation of thebiological role of melatonin in plants.","palabras_clave":"CD-MEKC|Melatonin|Tryptophan |Serotonin"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19450,"idioma_id":4,"titulo":"Melatonin in Arabidopsis thaliana acts as plant growth regulator at low concentrations and preserves seed viability at high concentrations","resumen":"Since the discovery of melatonin in plants, several roles have been described for different species, organs,and developmental stages. Arabidopsis thaliana, being a model plant species, is adequate to contribute tothe elucidation of the role of melatonin in plants. In this work, melatonin was monitored daily by UHPLCMS\/MS in leaves, in order to study its diurnal accumulation as well as the effects of natural and artificiallight treatments on its concentration. Furthermore, the effects of exogenous application of melatonin toassess its role in seed viability after heat stress and as a regulator of growth and development ofvegetative tissues were evaluated. Our results indicate that melatonin contents in Arabidopsis werehigher in plants growing under natural radiation when compared to those growing under artificialconditions, and its levels were not diurnally-regulated. Exogenous melatonin applications prolongedseed viability after heat stress conditions. In addition, melatonin applications retarded leaf senescence.Its effects as growth promoter were dose and tissueedependent; stimulating root growth at low concentrationsand decreasing leaf area at high doses.","palabras_clave":"Arabidopsis thaliana|Germination|Melatonin|Senescence|UHPLC-MS\/MS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19451,"idioma_id":4,"titulo":"Identification of N-benzylacetamide as a major component of human plasmatic metabolic profiling of benznidazole","resumen":"Chagas disease is an endemic infection in Latin America with a high health impact. Caused by the parasite Trypanosoma cruzi,   it has expanded to non-endemic regions such as North America and   European countries via immigration of infected people. This infectious   disease has been rising in the ranking of international health   priorities due to the growing migration flows from endemic to   non-endemic areas. Benznidazole (BZN), a nitroheterocyclic drug, is one   of the two trypanocidal drugs currently in clinical use, associated with   significant adverse drug reactions (ADRs). Mammalian metabolism of BNZ   has been poorly studied, including the potential role of metabolites on   both toxicity and anti-parasitic activity. High-resolution UPLC\/MS\/MS   was used to analyze three plasma samples obtained from pediatric   patients under BNZ treatment in steady state. Spectroscopic and   structural criteria were applied to identify BNZ and accompanying   substances from chromatographic signals. From all detected species, two   can be undoubtedly associated with the BNZ and N-benzylacetamide   molecules, the second one being a fragment of the parent drug (BZN).   From the obtained results, two hypotheses could be formulated. The first   one is to relate the presence of N-benzyl   acetamide with the hepatic metabolism of BNZ. The second hypothesis has   to do with the possible trypanocidal activity of this metabolite, as   well as its role in the development of side effects, associated with the   pharmacotherapy. Complementary studies should be carried out to   determine the possible association of this metabolite with the BNZ   treatment stages, patient?s clinical features, ADRs, and trypanocidal   effectiveness.","palabras_clave":"BENZNIDAZOL|CHAGAS DISEASE|METABOLITE|NITROCOMPOUNDS|PEDIATRIC PHARMACOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19452,"idioma_id":4,"titulo":"A review: Quorum sensing in Bradyrhizobium","resumen":"Quorum sensing (QS) systems are an important form of cellular communication in bacteria. QS systems are based on the synthesis and secretion of a chemical signal (autoinducer) that accumulates as a  function of population growth until reaching a threshold concentration that permits coordinated expression of certain genes that regulate bacterial physiology and behavior. A wide variety of soil bacteria  (rhizobia) capable of establishing symbiotic associations with plants produces small chemical signaling molecules to communicate among themselves for physiological adaptation to environmental changes.  Most species of rhizobia associated with legume plants have QS systems that regulate their behavior in a variety of soil microhabitats, including the establishment of symbiosis with the host plant. Species of the large, complex genus Bradyrhizobium are ecologically and agriculturally important, but present knowledge is limited and fragmentary regarding their QS communication systems, types of autoinducer produced, and biological processes regulated by QS. Therefore, the objective was to review findings to date on QS mechanisms in Bradyrhizobium, and the role of these mechanisms in symbiosis development and bacterial survival strategies. Bacteria of genus Bradyrhizobium produce a variety of QS signaling molecules, some of which are not found in any other bacterial genus. Of particular interest are the synthesis of bradyoxetin by Bradyrhizobium japonicum and its role in symbiosis regulation, and the synthesis of various branched homoserine lactones (HSLs) by other Bradyrhizobium species. In peanutnodulating  strains, these HSLs are associated with the processes of biofilm formation, motility, and autoaggregation. A proposed model is presented of QS mechanisms in Bradyrhizobium strains and the physiological processes regulated. The findings reviewed here provide a basis for future studies of QS communication systems in rhizobia and of regulatory mechanisms in bacterial behavior and ecophysiology","palabras_clave":"Chemical signals|quorum sensing|symbiosis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19453,"idioma_id":4,"titulo":"Food and habitat choice in the spider crab Leucippa pentagona (Majoidea, Epialtidae) in Bahía Bustamante, Patagonia,  Argentina.","resumen":"The aim of the present study was to analyze the feeding strategy and spatial distribution of the spider crab Leucippa pentagona in Bahía Bustamante (Patagonia, Argentina). Several microhabitat variables that could influence the spatial distribution of this crab were related to its different life stages by using redundancy analysis (RDA). Regarding its feeding preferences, we found that the Sphacelariales Halopteris spp. and Sphacelaria fusca, epiphytes of the red alga Gracilaria gracilis, represented over 75% of its diet. Conversely, consumption of G. gracilis was low throughout the year. These feeding preferences can be related to the higher proportion of ash-free dry mass of Sphacelariales. A close association was observed between G.gracilis biomass and recruits and mature crabs; this relationship was stronger at critical periods of the crab?s life cycle such as incubation or molt. Intermolt juveniles were related to G. gracilis as well as to other species of macroalgae. Our results suggest that G. gracilis plays a key role in the small-scale distribution of L. pentagona in Bahía Bustamante, providing food and shelter he consumption of G. gracilis epiphytes allows L. pentagona to maintain high foraging rates in safe living sites, minimizing the damage on G. gracilis.","palabras_clave":"LEUCIPPA|GRACILARIA|MICROHABITAT|EPIFITOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19454,"idioma_id":4,"titulo":"'Transition-Metal-Free' Synthesis of Carbazoles by Photostimulated Reactions of 2-Halo[1,1-biphenyl]-2-amines","resumen":"An efficient and simple protocol  for the preparation of a series of 9H-carbazoles  by photostimulated SRN1 substitution reactions is presented.  Substituted 9H-carbazoles were  synthesized from low to excellent yields (up to 96%) through an intramolecular  C-N bond formation of 2´-halo-[1,1´-biphenyl]-2-amines by the photoinitiated SRN1  mechanism under mild and transition-metal free conditions. The biphenyl  amines used as substrates were obtained with isolated yields ranging from 21%  to 84% by two approaches: A) the cross-coupling Suzuki-Miyaura reaction, and B)  the radical arylation of anilines. Some key aspects of the proposed mechanism  were evaluated at the B3LYP\/6-311+G* level.","palabras_clave":"SRN1|CARBAZOLES|SYNTHESIS|PHOTOCHEMISTRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19455,"idioma_id":4,"titulo":"A note on the continuability of some Lienard's Type System","resumen":"In this note we obtain sufficient conditions under which we can guarantee the continuability of solutions of a system which contain the classical Liénard equation.","palabras_clave":"Boundedness|Stability|Lienard Equation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19456,"idioma_id":4,"titulo":". Secondary lahar hazard assessment for Villa la Angostura, Argentina, using Two-Phase-Titan modelling code during 2011 Cordón Caulle eruption","resumen":"This paper presents the results of lahar modelling  in the town of Villa La Angostura (Neuquén-Argentina)  based on the Two-Phase-Titan modelling computer code. The  purpose of this exercise is to provide decision makers with a  useful tool to assess lahar hazard during the 2011 Puyehue-  Cordón Caulle Volcanic Complex eruption. The possible occurrence  of lahars mobilized from recent ash falls that could  reach the city was analysed. The performance of the Two-  Phase-Titan model using 15m resolution digital elevation  models (DEMs) developed from optical satellite images and  from radar satellite images was evaluated. The output of  these modellings showed inconsistencies that, based on field  observations, were attributed to bad adjustment of the DEMs  to real topography. Further testing of results using more accurate  radar-based 10m DEM, provided more realistic predictions.  This procedure allowed us to simulate the path of flows  from Florencia, Las Piedritas and Colorado creeks, which  are the most hazardous streams for debris flows in Villa La  Angostura. The output of the modelling is a valuable tool  for city planning and risk management especially considering  the glacial geomorphic features of the region, the strong  urban development growth and the land occupation that has  occurred in the last decade in Villa La Angostura and its surroundings","palabras_clave":"LAHAR HAZARDS|VILLA LA ANGOSTURA|TWO PHASE TITAN|CORDON CAULLE ERUPTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19457,"idioma_id":4,"titulo":"New geochemical and isotopic insights to evaluate the geothermal resource of the hydrothermal system of Rosario de la Frontera (Salta, northern Argentina)","resumen":"In this study, the chemical and isotopic composition of thermo-mineral springs from the Rosario de la Fronterahydrothermal system was used to construct a conceptual model describing the source regions the thermalfluids and the chemical?physical processes controlling the chemistry of waters and dissolved gases duringtheir underground circulation. The main hydrothermal reservoir, hosted within the Cretaceous Pirgua Subgroupdeposits, is fed by meteoric water and shows a Na-HCO3 composition produced by water?rock interactionsinvolving sedimentary formations mostly consisting of conglomerates and sandstones, which are interbeddedwith alkaline volcanic rocks and shales and limestone deposits. This aquifer also receives significant contributionsof crustal CO2 and He from mantle degassing, the latter being likely favored by the regional tectonic assessmentthat is characterized by a deep detachment (at about 10 km depth) in the basement of the Santa Bárbara thickskinnedthrust system and a thinned lithosphere. The uprising thermal fluids mix with a relatively high salinityNa-Cl dominated aquifer produced by the interaction of meteoric water with the Tertiary Anta Formation evaporite.The temperatures of the hydrothermal reservoir, estimatedwithwater geothermometers, are up to 130 °C,which are consistent with the thickness of the hydrothermal circuit (2700-3000 m) and the relatively high localgeothermal gradient (~40 °C\/km). These results suggest that the heat stored in the fluid phase of RFHS is up to~1 × 1018 J, a value significantly higher (20%) than that previously estimated assuming an average reservoirtemperature of 90 °C.","palabras_clave":"Salta Region|Geothermal Resource|water geochemistry|hydrotermal system"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19458,"idioma_id":5,"titulo":"El género Leucocoprinus Pat. (Agaricaceae-Agaricommycetes) en el norte de Argentina y Paraguay","resumen":"ABSTRACT ? The genus Leucocoprius Pat. (Agaricaceae-Agaricomycetes)in northern Argentina and Paraguay. Five species of Leucocoprinus collectedrecently in northern Argentina and Paraguay were identifid. Four of them (L.birnbaumii, L. cepistipes, L. cretaceous and L. straminellus) are reported forthe fist time in Paraguay and Leucocoprinus birnbaumii, L. cepistipes and L.straminellus in northeastern Argentina. The range of L. cretaceous is expanded tothe Chaco and Formosa provinces (Argentina). The specimens are characterizedmorphologically, illustrated and a species identifiation key region is provided","palabras_clave":"ATLANTIC FOREST|BASIDIOMYCOTA|CHACO REGION|YUNGAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19459,"idioma_id":4,"titulo":"Digestive flexibility in response to environmental salinity and temperature in the non-symbiotic sea anemone Bunodosoma zamponii","resumen":"                The knowledge about digestive physiology of sea  anemones at biochemical level is scarce, particularly in South American  species. The final digestion of various  dietary glycogenic carbohydrates depends  on suitable levels of disaccharidases (ie: maltase). In spite of their  important physiological role for maintaining glucose homeostasis, to our  knowledge, no studies occur about the occurrence of maltase activity in  coelenteron of sea anemones. The objective was to determine the existence and  biochemical characteristics of maltase activity in coelerenton mesenterial  filaments of the South American sea anemone Bunodosoma  zamponii.&nbsp; Sea anemones (n=10) captured in the intertidal zone of Punta  Cantera (Mar del Plata, Buenos Aires, Argentina) were maintained at 35 psu, 12  h L\/12 h O and 20°C The supernatant (10000xg) from homogenate mesenteric  filaments was used. Maltase activity was assayed by hydrolysis of 28.0 mM of maltose in 0.1 M maleate\/NaOH buffer (pH  6.4) at 37°C.  To study the effect of pH, maltose concentration, and temperature the activity  was deter­mined at different: pH levels (5.9-8.4), substrate concentra­tions  (0.56-42 mM) and temperature (4-37°C) of the reaction mixture,  respectively.&nbsp; Maltase activity was high  over the wide range of pH and temperature tested and exhibited Michaelis-Menten  kinetics (Km 0.31± 0.4 mM).  Our results show the occurrence of maltase activity in mesenterial filaments of  B. zamponii suggesting&nbsp; its capacity for digestion and potential use  of various glycogenic substrates as nutrient sources. The high activity over a  wide range of pH and temperature suggests that this capacity would be  maintained under varying physiological and\/or environmental conditions.   ","palabras_clave":"Intertidal|Phenotypic flexibility|Digestive enzymes|Non-symbiotic anemones"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19460,"idioma_id":4,"titulo":"Integrative study at the biochemical level in a intertidal crab from Mar Chiquita coastal lagoon (Buenos Aires, Argentina) upon acute exposure to high zinc","resumen":"Abstract In Mar Chiquita coastal lagoon (Argentina) acute high increases in Zinc (Zn) occur  reaching 1.22 mg x L-1, but integrative studies on possible effects at the  biochemical-physiological level on conspicuous invertebrate species inhabiting this area are  lacking. We determined body and vital organs mass, hyper\/ hypo-regulatory capacity;  Na+-K+ATPase activity alkaline phosphatases (AP) activities in chela muscle, maltase and  sucrase activities in the hepatopancreas and glycemia of adult males of the euryhaline crab  Neohelice granulata upon exposure during 96 h to 1.22 mg x L-1 Zn in hyper- and hypo-osmotic  media. Body, anterior and posterior gills, hepatopancreas and chela muscle mass and hyper and  hypo-regulatory capacities were not affected suggesting maintenance of body and physiological  condition. The fact that upon Zn exposure in hypo-osmotic media Na+-K+ATPase activity  decreased in posterior gills while increased in anterior gills along with increased glycemia  suggests the occurrence of biochemical compensatory adjustments. Since no changes occurred  in maltase and sucrase activities in the hepatopancreas or AP in chela muscle in hypo-osmotic  media, other key metabolic parameters appeared not to be comprised. The fact that in  hyper-osmotic media Zn exposure no effects were found suggests the occurrence of specific  effects of Zn along upon a hypo-osmotic challenge","palabras_clave":"ESTUARIES|GLUCOSE HOMEOSTASIS|EURYHALINE CRABS|OSMOTIC ADAPTATION |HEAVY METAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19461,"idioma_id":4,"titulo":"A kinetic study of textile dyeing wastewater degradation by Penicillium chrysogenum","resumen":"The  potential of Penicillium chrysogenum to decolorize azo dyes and a real industrial textile wastewater was studied. P.  chrysogenum was able to decolorize and degrade three azo dyes (200 mg.L-1), either  independently or in a mixture of them, using glucose as a carbon source. A kinetic model for degradation was developed and it allowed predicting  the degradation kinetics of the mixture of the three azo dyes. In addition, P. chrysogenum was able to decolorize  real industrial wastewater. The kinetic model proposed was also able to predict  the decolorization of the real wastewater. The calibration of the proposed  model makes it a useful tool for future wastewater facilities design and for  practical applications","palabras_clave":"FUNGAL BIODEGRADATION|AZO DYES|WASTEWATER|DEGRADATION KINETICS|PHYTOTOXICITY|FTIR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19462,"idioma_id":4,"titulo":"Exploring analyte response in an ESI-MS system with different chemometric tools","resumen":"Analyte response in mass  spectrometry with electrospray ionization was studied for a typical single  quadrupole LC-MS instrument, as a function of eight instrumental variables and  nine physicochemical properties for a variety of small molecules. Due to the  high number of factors, three different experimental designs have been applied  in order to balance the amount of gathered information and the number of  experimental runs. The analyses were made by nonlinear modeling through  artificial neural networks. One of the experimental designs (a Plackett-Burman  design) involved 20 compounds of different chemical nature, with 12 runs per  compound. It allowed finding general instrumental conditions capable of giving  enough sensitivity for all the compounds; some relationships among instrumental  parameters and physicochemical properties have also been identified. The other  two experimental designs (a 73 runs Doehlert design, and a 19 runs fractional  factorial design) were aimed at obtaining optimum instrumental sensitivity for  one specific compound; they both allowed identifying the RF component of the  Q-array and the desolvation line temperature as the most influential  instrumental factors and let us detect several associations among instrumental  variables. In order to select the most efficient optimization strategy, these  two methods were compared. The fractional factorial design, which requires a much  smaller number of runs, was found suitable to identify the optimum working  zone, with a fair economy of experiments. ","palabras_clave":"Electrospray ionization mass spectrometry|Small molecules|Optimization|Experimental design|Modeling|Arti&#64257;cial neural networks"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19463,"idioma_id":4,"titulo":"Sunflower germin-like protein HaGLP1 promotes ROS accumulation and enhances protection against fungal pathogens in transgenic Arabidopsis thaliana","resumen":"Germin-like proteins (GLPs) are a large, diverseand ubiquitous family of plant glycoproteins belonging tothe Cupin super family. These proteins have been widelystudied because of their diverse roles in important plantprocesses, including defence. The novel sunflower geneHaGLP1 encodes the first germin-like protein characterizedfrom the family Asteraceae. To analyse whetherconstitutive in vivo expression of the HaGLP1 gene maylead to disease tolerance, we developed transgenic Arabidopsisplants that were molecularly characterized andbiologically assessed after inoculation with Sclerotiniasclerotiorum or Rhizoctonia solani. HaGLP1 expression inArabidopsis plants conferred tolerance to S. sclerotiorum atthe first stages of disease and interfered with R. solaniinfection, thus giving rise to significant protection againstthe latter. Furthermore, HaGLP1 expression in Arabidopsisplants elevated endogenous ROS levels. HaGLP1-inducedtolerance does not appear to be related to a constitutiveinduction of the plant defence or the ROS-related genesexamined here. In conclusion, our data suggest thatHaGLP1 is an interesting candidate for the engineering ofplants with increased fungal tolerance and that this genecould also be useful for the selection of naturally overexpressingsunflower genotypes for conventional breedingpurposes","palabras_clave":"SUNFLOWER|DISEASE RESISTANCE|GERMIN-LIKE PROTEINS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19464,"idioma_id":4,"titulo":"Fish assemblage of a Pampean shallow lake, a story of instability","resumen":"Pampean lakes are characterised by the  alternation of flood and drought periods, but little is  known about its effects on fish assemblage in an  extended temporal scale. This study analyses the  temporal variability of the fish assemblage in Chascomu  ´s Lake, and discusses the role of temperature and  precipitation as potential drivers of fish composition  shifts. Data acquisition was based on experimental  fishing performed from 1999 to 2013 and from  historical fishing records. Two alternative fish assemblage  configurations were identified by cluster analysis.  Odontesthes bonariensis, Parapimelodus valenciennis  and Cyphocharax voga were the dominant species,  which accounted for 70?80% of the relative abundance.  The species O. bonariensis showed temporal  fluctuations in its representativeness, changing from  dominant to almost absent, whereas C. voga and P.  valenciennis changed their abundance following a  similar pattern along time. When historical data were  considered, Platanichthys platana appeared as the  fourth most relevant species. Precipitation, critical  temperatures and fish mortalities were identified as the  main drivers of species abundance shifts. This study  highlights the importance of long-term assessments to  understand the influence of climatic factors and the  need to maintain or restore natural ecological processes  as the basis to support dynamic sustainable fisheries in  Pampean shallow lakes","palabras_clave":"Environmental variability|Pampean region|Fish assemblage structure|Climatic fluctuations|Chascomús Lake"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19465,"idioma_id":4,"titulo":"New approaches for growth improvement in pejerrey Odontesthes bonariensis culture","resumen":"El pejerrey es la especie de mayor importancia deportiva en lagos someros templados y embalses de Argentina y el desarrollo de su acuicultura data de cien años atrás. Un impedimento común para el desarrollo de la acuicultura del  pejerrey es el pobre crecimiento que manifiesta bajo cultivo intensivo. El objetivo de este estudio fue evaluar la posibilidad de alcanzar y mantener altas tasas de crecimiento en el pejerrrey mediante cultivo semi-intensivo. Se instalaron cuatro jaulas flotantes en la laguna La Salada de Monasterio, sembrándose cada una con 300 juveniles (10.22 ±0.38cm; 6.52 ±0.82g). Desde enero hasta marzo los peces se alimentaron con el zooplancton natural de la laguna, mientras que desde abril hasta septiembre dos jaulas fueron suplementadas diariamente con alimento balanceado, dejándose las otras dos como controles. Los peces bajo dietas suplementadas mostraron crecimientos significativamente superiores (17.5 ±0.98cm; 41.05 ±8.55g) a los de las jaulas control (15.02 ±0cm ; 23.5 ±0.84g), excediendo incluso los conocidos en el cultivo de pejerrey en períodos similares. Los resultados obtenidos sugieren que el potencial de crecimiento del pejerrey no está siendo explotado en su totalidad bajo las técnicas de cultivo tradicionales y puede mejorarse mediante el cultivo semiintensivo. En consecuencia es necesaria una mejor comprensión de los requerimientos nutricionales del pejerrey para incrementar sus tasas de crecimiento y así mejorar su cultivo.","palabras_clave":"AQUACULTURE|FISH GROWTH|FLOATING CAGE|GROWTH RATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19466,"idioma_id":4,"titulo":"Mesenchymal Stromal Cells Overexpressing Vascular Endothelial Growth Factor in Ovine Myocardial Infarction","resumen":"Mesenchymal stromal cells (MSCs) are cardioprotective in acute myocardial infarction (AMI). Besides, we have shown that intramyocardial injection of plasmid-VEGF165 (pVEGF) in ovine AMI reduces infarct size and improves left ventricular (LV) function. We thus hypothesized that MSCs overexpressing VEGF165 (MSCs-pVEGF) would afford greater cardioprotection than non-modified MSCs or pVEGF alone. Sheep underwent an anteroapical AMI and, 1 week later, received intramyocardial MSCs-pVEGF in the infarct border. One month post treatment, infarct size (magnetic resonance) decreased by 31% vs pre-treatment. Of note, myocardial salvage occurred predominantly at the subendocardium, the myocardial region displaying the largest contribution to systolic performance. Consistently, LV ejection fraction recovered to almost its baseline value because of marked decrease in end-systolic volume. None of these effects were observed in sheep receiving non-transfected MSCs or pVEGF. Although myocardial retention of MSCs decreased steeply over time, the treatment induced significant capillary and arteriolar proliferation, which reduced subendocardial fibrosis. We conclude that in ovine AMI, allogeneic VEGF-overexpressing MSCs induce subendocardial myocardium salvage through microvascular proliferation, reducing infarct size and improving LV function more than non-transfected MSCs or the naked plasmid. Importantly, the use of a plasmid rather than a virus allows for repeated treatments, likely needed in ischemic heart disease.","palabras_clave":"MESENCHYMAL STROMAL CELLS|VEGF|ACUTE MYOCARDIAL INFARCTION|SHEEP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19467,"idioma_id":4,"titulo":"Response of strawberry plants inoculated with Azospirillum and Burkholderia at field conditions","resumen":"The use of synthetic fertilizers is the most common practice used to incorporate nutrients in agricultural soils; these are expensive leading to increases in the total crop-production costs. Even more, this traditional cultivation management may turn inefficient and polluting as part of them can be lost by lixiviation or become insoluble by cation exchange. Therefore, the aim of this study was to evaluate the agronomic response of strawberry plants (Fragaria ananassa Duch.) inoculated with two native PGPB as a biotechnological alternative to the plant nutrition.  The experiment was carried out under field conditions during 2014, using strawberry plants cv. ´Fortuna Florida´ inoculated with the local strains Azospirillum brasilense REC3 and Burkholderia vietnamensis AFTV3, applied individually and combined.  Results showed greater growth index (30%) and relative chlorophyll content in leaves (10%) in inoculated plants compared to non-inoculated controls, and also increased commercial fruit yield in plants inoculated with A. brasilense REC3 (12.6%), B. vietnamensis AFTV3 (13.4%) and both (7.2%) in comparison with uninoculated controls.","palabras_clave":"Fragaria ananassa|Azospirillum|Burkholderia|PGPB"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19468,"idioma_id":4,"titulo":"Clinical and microbiological features of bacteremia caused by Enterococcus  faecalis","resumen":"Introduction: Enterococcus faecalis is a frequent etiologic agent of invasive infections in hospitalized patients. The aim of this study was to analyze clinical and microbiological features of bacteremia caused by E. faecalis.Methodology: Between 2011 and 2013, significant bacteremia caused by E. faecalis in hospitalized patients was studied. Patient characteristics, comorbid conditions, and 14-day mortality were recorded. Virulence genes esp, gelE, and cylA; opsonophagocytosis resistance; resistance to bactericidal effect of normal serum; beta lactamase production; and susceptibility to ampicillin, vancomycin, teicoplanin, gentamicin, and streptomycin were investigated.Results: E. faecalis strains were recovered from 33 bacteremic patients. Polymicrobial bacteremia was diagnosed in 2 patients; 10 patients died. Virulence genes were found in strains from both deceased patients and survivors. Sources of bacteremia included urinary tract infections (36.4%), vascular catheters (15.1%), abscesses (9.1%), and unknown (48.5%). Underlying diseases included cancer (30.3%), diabetes (36.4%), cirrhosis (6.1%), renal (36.4%), and chronic obstructive pulmonary disease (2.0%). Co-morbidities included alcohol use (26.1%); glucocorticoid therapy (19.0%); prior antibiotic therapy (60.6%); and central venous (21.2%), arterial (12.1%), and urinary (63.6%) catheters. Also, 57.6% of patients came from the intensive care unit (ICU); 33.3% had mechanical ventilation. Significant mortality-associated conditions included polymicrobial bacteremia, oncological disease, APACHE II score &#8805; 20, ICU stay, renal disease, central venous catheter, and mechanical ventilation.Conclusions: Outcome of patients was associated with their status and not with the presence of virulence genes in E. faecalis strains. A significant percentage of bacteremia had undetermined origin. An alternate origin may be the gastrointestinal tract, through translocation.","palabras_clave":"BACTEREMIA|E. FAECALIS|HOSPITAL|VIRULENCE DETERMINANTS|CO-MORBIDITY|MORTALITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19469,"idioma_id":4,"titulo":"Osteoderm histology of Proterochampsia and Doswelliidae (Reptilia: Archosauriformes) and their evolutionary and paleobiological implications","resumen":"Postcranial osteoderms are commonly developed in the major lineages of Archosauriformes, including forms such as proterochampsids and doswelliids.Here, we survey the histology of osteoderms of the doswelliids Archeopelta arborensis and Tarjadia ruthae, and the proterochampsids Chanaresuchus bonapartei and Pseudochampsa ischigualastensis to understand betterthe morphogenesis of these skeletal elements. Whereas, the Doswelliid osteoderms possess a trilaminar organization, in which two cortices (external and basal) can be differentiated from an internal core of cancellous bone, theseelements are compact structures in proterochampsids. The osteoderms of P. ischigualastensis are avascular and they consist entirely of parallel-fibered bone. Conversely, the osteoderms of C. bonapartei are well vascularizedstructures composed of zones of woven-fibered bone and annuli of parallel-fibered bone. The rather simple microstructure observed in P. ischigualastensis osteoderms suggests that these elements grew at a constant, low rate.Compared with proterochampsids, doswelliid osteoderms possess a more complex histology, which appears to be linked to variations in the growth rate during the osteoderm formation and also to the development of the external ornamentation. A comparison of our findings with the results of earlier studies on other archosauriforms (phytosaurs and pseudosuchians) reveals that the general osteoderm histology of doswelliids bears a closer resemblance to that of phytosaurs and pseudosuchians than the proterochampsid osteoderm microstructure. If all archosauriform osteoderms are homologous structures, the closerresemblance of doswellid osteoderm microstructures to that of phytosaurs and pseudosuchians is in agreement with the hypothesis that doswellids are more closely related to archosaurs than proterochampsids.","palabras_clave":"doswelliids|proterochampsidsr|microanatomy|bone microstructure|integument|dermal armor"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19470,"idioma_id":4,"titulo":"PALEOBIOLOGY OF TITANOSAURS: REPRODUCTION, DEVELOPMENT, HISTOLOGY, PNEUMATICITY, LOCOMOTION AND NEUROANATOMY FROM THE SOUTH AMERICAN FOSSIL RECORD","resumen":"Much of the current paleobiological knowledge on titanosaur sauropods was  attained in just the last fifteen years, in particular that related to reproductive and  developmental biology. In recent years it has also been progress on other poorly explored  topics, such as pneumaticity, architecture and locomotion, and reconstruction endocasts and  associated structures. Some titanosaurs laid numerous, relatively small Megaloolithidae  eggs (with diameters ranging from 12 to 14 cm) in nests dug on the ground and, as is  known from the South American records, probably eggs of multispherulitic morphotype.  During ontogeny, certain titanosaurs displayed some variations in cranial morphology,  some of them likely associated with the differing feeding habits between hatchlings and  adults. The osseous tissue of some adult titanosaurs was rapidly and cyclically deposited  showing a greater degree of remodeling than in other sauropods. Saltasaurines, in  particular, show evidence of postcranial skeletal pneumaticity in both axial and  appendicular skeleton, providing clues about soft tissue anatomy and the structure of the  respiratory system. Titanosaurs like all sauropods were characterized by being fully  quadrupedal, although some appendicular features and putative trackways indicate that  their stance was not as columnar as in other sauropods. These anatomical peculiarities are  significantly developed in saltasaurines, a derived group of titanosaurs. Compared with  other sauropods, some titanosaurs seem to have had very poor olfaction but would have  been capable of capturing sounds in a relatively wide range of high frequencies, although  not to the extent of living birds.","palabras_clave":"TITANOSAUR|NEUROANATOMY|HISTOLOGY|PNEUMATICITY|DENTITION|REPRODUCTION|EMBRYOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19471,"idioma_id":5,"titulo":"El Modelado Matemático de Rendimiento y el Proceso de Sintonización Dinámica","resumen":"La sintonización constituye un proceso fundamental en el ciclo de vida de las aplicaciones informáticas, dado que a través de las sucesivas fases de monitoreo, análisis de rendimiento y modificación, permite ajustar los parámetros de funcionamiento y el comportamiento del programa. La complejidad de la sintonización dinámica radica en las dificultades existentes para la toma de decisiones efectivas, concisas y aplicables en sincronía con la ejecución misma del programa. En este artículo presentamos la importancia y las ventajas que ofrece la utilización de modelos matemáticos de rendimiento en la toma de decisiones, centrándonos en la utilización de un modelo de rendimiento en particular que permite adaptar la cantidad de recursos computacionales utilizados por aplicaciones paralelo\/distribuidas Master\/Worker al estado del entorno de ejecución.","palabras_clave":"MODELO DE RENDIMIENTO|SINTONIZACIÓN AUTOMÁTICA|MODELO MASTER\/WORKER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19472,"idioma_id":5,"titulo":"Método de Optimización Paralelo con Doble Jerarquía de Procesamiento","resumen":"En este trabajo se presenta un modelo paralelo basado en islas de la metaheurística Evolución Diferencial, que posee dos niveles de jerarquía de comunicación entre procesos. El nivel superior lo constituyen las diferentes islas que se conectan con topología de anillo. El nivel inferior comprende la estructura interna de cada isla, donde cada una de ellas está integrada por un proceso coordinador y subprocesos que realizan la búsqueda sobre un espaciodeterminado. El modelo alcanza buenos resultados en cuanto a calidad de la aproximación y tiempo de ejecución.","palabras_clave":"EVOLUCION DIFERENCIAL|METODOS DE OPTIMIZACION|COMPUTACION DE ALTO RENDIMIENTO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19473,"idioma_id":5,"titulo":"Método de Reducción de Incertidumbre Aplicado a la Predicción de Incendios: Análisis de Sintonización Estática","resumen":"La predicción de cualquier fenómeno es una tarea compleja tanto por los modelos involucrados, por la utilización de grandes recursos computacionales, y por la presencia de incertidumbre en el proceso de predicción. El desarrollo de métodos de reducción de incertidumbre es necesario para lograr predicciones más acordes a la realidad. El Sistema Estadístico Evolutivo con Modelo de Islas (ESS-IM, por sus siglas en inglés) es un método general de reducción de incertidumbre que ha sido aplicado con éxito a la predicción de incendios forestales. ESS-IM opera con una serie de parámetros de configuración inicial que condicionan el funcionamiento del componente evolutivo del método. Hasta el momento el método ha sido utilizado con una configuración clásica de valores para dichos parámetros, por lo que, con el objetivo de mejorar el rendimiento del mismo, en este trabajo se propone un análisis de sintonización para dichos parámetros.","palabras_clave":"PREDICCIÓN|REDUCCIÓN DE INCERTIDUMBRE|SINTONIZACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19474,"idioma_id":4,"titulo":"Detection and quantification of reactive oxygen species (ROS) in indoor air","resumen":"Reactive oxygen species (ROS), such as free radicals and peroxides, are environmental trace pollutants potentially associated with asthma and airways inflammation. These compounds are often not detected in indoor air due to sampling and analytical limitations. This study developed and validated an experimental method to sample, identify and quantify ROS in indoor air using fluorescent probes. Tests were carried out simultaneously using three different probes: 2&#8242;,7&#8242;-dichlorofluorescin (DCFH) to detect a broad range of ROS, Amplex ultra Red® (AuR) to detect peroxides, and terephthalic acid (TPA) to detect hydroxyl radicals (HO?). For each test, air samples were collected using two impingers in series kept in an ice bath, containing each 10 mL of 50 mM phosphate buffer at pH 7.2. In tests with TPA, that probe was also added to the buffer prior to sampling; in the other two tests, probes and additional reactants were added immediately after sampling. The concentration of fluorescent byproducts was determined fluorometrically. Calibration curves were developed by reacting DCFH and AuR with known amounts of H2O2, and using known amounts of 2-hydroxyterephthalic acid (HTPA) for TPA. Low detection limits (9?13 nM) and quantification limits (18?22 nM) were determined for all three probes, which presented a linear response in the range 10?500 nM for AuR and TPA, and 100?2000 nM for DCFH. High collection efficiency (CE) and recovery efficiency (RE) were observed for DCFH (CE=RE=100%) and AuR (CE=100%;RE=73%) by sampling from a laboratory-developed gas phase H2O2 generator. Interference of co-occurring ozone was evaluated and quantified for the three probes by sampling from the outlet of an ozone generator. The method was demonstrated by sampling air emitted by two portable air cleaners: a strong ozone generator (AC1) and a plasma generator (AC2). High ozone levels emitted by AC1 did not allow for simultaneous determination of ROS levels due to high background levels associated with ozone decomposition in the buffer. However, emitted ROS were quantified at the outlet of AC2 using two of the three probes. With AuR, the concentration of peroxides in air emitted by the air cleaner was 300 ppt of H2O2 equivalents. With TPA, the HO? concentration was 47 ppt. This method is best suited to quantify ROS in the presence of low ozone levels.","palabras_clave":"ROS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19475,"idioma_id":4,"titulo":"Taphonomy and depositional environment of a Lower Cretaceous monospecific dinosaur bone assemblage (Puesto Quiroga Member, Lohan Cura Formation), Neuquén Province, Argentina","resumen":"The Puesto Díaz Quarry (Lohan Cura Formation, Lower Cretaceous of Neuquén Basin, Argentina) consists of a monospecific dinosaur bone assemblage that includes 126 specimens from, at least, three individuals of the rebbachisaurid sauropod Comahuesaurus windhauseni. The bonebed was originated as a debris flow of an ephemeral-river bed, in distal areas of low relief. Bones are disarticulated, three-dimensionally distributed through the host facies, showing a normal grading arrangement, which can be correlated with the size, shape and hydraulic behavior inferred for each specimen. Taphonomic evidence suggests that the bones did not experience a prolonged transport, and that these were quickly buried by the debris flow event. The fact that there are more than one individual of the same species suggests a mass mortality by a catastrophic event. Scattered skeletal elements would indicate that the corpses must have been subaerially exposed, long enough to allow disarticulation by scavenging, decay, and defleshing.","palabras_clave":"Dinosauria|Sauropoda|Taphonomy|Lower Cretaceous|Patagonia|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19476,"idioma_id":4,"titulo":"REPTILES FROM LITHOGRAPHIC LIMESTONES OF THE LOS CATUTOS MEMBER (MIDDLE-UPPER TITHONIAN), NEUQUÉN PROVINCE, ARGENTINA: AN ESSAY ON ITS TAXONOMIC COMPOSITION AND PRESERVATION IN AN ENVIRONMENTAL AND GEOGRAPHIC CONTEXT","resumen":"The lithographic limestones of the Los Catutos Member (Vaca Muerta   Formation, Neuquén Province, Argentina) (late middle?early upper Tithonian) bear a   great diversity of marine reptiles. These deposits are unique in the Southern Hemisphere    since the record of lithographic limestones from the Upper Jurassic is restricted to the    Northern Hemisphere, particularly to Western Europe. Some European basins are very   close in age (upper Kimmeridgian?lower Tithonian) but they do not reach the upper?31   middle Tithonian. Additionally, in the European basins the marine reptiles are mixed 32   with continental biota whereas in Los Catutos Member the biota is exclusively marine, 33   being the pterosaurs the only exception. The strictly marine biota is composed by 34   ichthyosaurs, two different species of turtles, one crocodyliform, and one plesiosaur. 35   The taxonomic composition of Los Catutos Member is very similar to that found in 36   Cerro Lotena (Portada Covunco Member, middle Tithonian) (Vaca Muerta Formation). 37   These members share the same turtle species and one metriorhynchid genus, while 38   ichthyosaurs only coincide at a family level. The knowledge resulting from the studies 39   of marine reptiles of the Los Catutos Member, as well as those found in other localities    of the Neuquén Basin, helped to fill an important gap in the evolution of each of the   represented clades. On this regard, they represent the only known marine reptiles from   Gondwana throughout the Jurassic\/Cretaceous transition, which is scarcely represented   in other regions of the world.","palabras_clave":"Marine reptiles|Neuquén Basin|Vaca Muerta Formation|South America"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19477,"idioma_id":4,"titulo":"Candida albicans up-regulates the Fas-L expression in liver Natural Killer and Natural Killer T cells","resumen":"After Candida albicans arrival to the liver, the local production of proinflammatory cytokines and the expanded intrahepatic lymphocytes (IHL) can be either beneficial or detrimental to the host. Herein we explored the balance between protective inflammatory reaction and liver damage, focusing our study on the contribution of TNF-ALPHA and Fas-Fas-L pathways in the hepatocellular apoptosis associated to C. albicans infection. A robust tissue reaction and a progressive increase of IL-1BETA, IL-6 and TNF-ALPHA were observed in infected animals. Blocking the biological activity of TNF-ALPHA did not modify the number of apoptotic cells observed in C. albicans infected animals. Fas-L molecule was up regulated on purified hepatic mononuclear cells and its expression progressed with the infection. In the IHL compartment, the absolute number of Fas-L+ NK and NKT cells increased on days 1 and 3 of the infection. C. albicans was also able to up regulate Fas-L expression in normal liver NK and NKT cells after in vitro contact. The innate receptor TLR2 was involved in this phenomenon. In the interplay between host  factors and evasion strategies exploited by pathogens, the mechanism supported here could represent an additional way that allows this fungus to circumvent protective immune responses in the liver.","palabras_clave":"CANDIDA ALBICANS|LINFOCITOS INTRAHEPATICOS NK|LINFOCITOS INTRAHEPATICOS NKT|FAS-L"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19478,"idioma_id":6,"titulo":"Long-necked chelid turtles from the Campanian of northwestern Patagonia with comments on K\/P survivorship of Yaminuechelys genus","resumen":"The long-necked chelid turtle Yaminuechelys aff. maior is described on thebasis of post-cranial material of two specimens from the lower-middle CampanianAnacleto Formation, nortwestern Patagonia (Argentina). These post-cranial remains aredescribed macroscopically (external morphology) andmicroscopically (histologicalsections of the shell). Although minor carapace and plastral differences are reported(e.g., extension of the axillary buttresses on visceral surfaces of the first costal bone,curled bridge peripheral bones,absence of a subrectangular fenestra retained in adults) the specimens exibit the shell morphology and surface ornamentation of specimensreferred to Y. maior (Staesche, 1929) from Paleocene levels of the Salamanca Formation(Central Patagonia). This assignment is supported by a phylogenetic analysis, in which the new material is the most closely related to Y. maior.As Yaminuechelys ishypothesized to be the sister taxon of Hydromedusa, the capabilitie of Hydromedusa tectifera to adapt to changing environments and the survivorship of Yaminuechelys genus in K\/P boundary is discussed.","palabras_clave":"Pleurodira|Chelidae|Upper Cretaceous|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19479,"idioma_id":4,"titulo":"Singularities on The Physicochemical Properties of Spontaneous AOT-BHD Unilamellar Vesicles in Comparison with DOPC Vesicles","resumen":"In the present work we study different physicochemical properties of the spontaneousunilamellar vesicles created by the catanionic ionic liquids-like surfactant benzyl-nhexadecyldimethylammonium1,4-bis-2-ethylhexylsulfosuccinate (AOT-BHD), using twodifferent fluorescent probes: 6-propionyl-2-(dimethylaminonaphthalene), PRODAN andtrans-4-[4-(dimethylamino)-styryl]-1-methylpyridinium iodide, HC.Steady-state and time resolved fluorescence emission spectroscopy allowed us to findunique properties on the AOT-BHD bilayer in comparison with vesicles formed with thetraditional phospholipid 1,2-dioleoyl-sn-glycero-3-phosphocholine, DOPC. From theemission results, we observed that the region of the bilayer close to the polar head of AOTBHDis a powerful electron donor environment, even larger than DOPC. Additionally, theAOT-BHD bilayer offers a less polar and slightly more viscous zone than the DOPC one.Thus, this particular bilayer is able to produce large incorporation of ionic and nonionicmolecules and is very promising to be used as nanocarrier in pharmacologic, cosmetic andfoods fields.","palabras_clave":"CATANIONIC SURFACTANT|UNILAMELLAR VESICLES|AOT-BHD|IONIC LIQUID"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19481,"idioma_id":4,"titulo":"Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain","resumen":"Adult hippocampal neurogenesis provides the dentate gyrus (DG) with heterogeneous populations of granule cells (GC) originated at different times. The specific contribution of these cells to the encoding of information arriving to the hippocampus is under current investigation. Here we show that spike trains arriving to the DG are channeled into activation of different populations of GC determined by the stimulation frequency and GC age. Immature GC respond to a wider range of afferent stimuli arriving at 1-40 Hz, whereas mature GC are less effective in following higher frequencies. This difference is dictated by the activation of feed forward inhibition, which predominantly restricts mature GC activation. Although it restricts frequency responsiveness, the stronger inhibition of mature GC results in a higher temporal fidelity compared to that of immature GC. Thus, activity arriving to the hippocampus at different frequencies activates two populations of neurons with variable frequency filters: immature cells, with wide range of responses, that are reliable transmitters of the incoming frequency, and mature neurons, with narrow responses to frequency, that are precise at informing the beginning of the stimulus, but with a sparse activity.","palabras_clave":"NEUROGENESIS|INHIBICION |CIRCUITOS NEURONALES|ELECTROFISIOLOGIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19482,"idioma_id":4,"titulo":"A NEW LATE TRIASSIC VERTEBRATE ASSEMBLAGE FROM NORTHWESTERN ARGENTINA","resumen":"The Quebrada del Barro Formation (QBF) is part of the continental Marayes-El Carrizal Basin, in NW Argentina. Here we report a diverse faunal assemblage recently discovered in the Quebrada del Barro Formation, along with a preliminary discussion of the taxonomic statusand affinities of numerous vertebrate specimens found at two localities where this unit is exposed. The new vertebrate association includes remains of at least 1 2 different new species related to six major vertebrate groups: Cynodontia, Testudinata, Sphenodontia, Pseudosuchia,Pterosauria, and Dinosauromorpha. The most abundant specimens in this faunal assemblage are opisthodontian sphenodonts, tritheledontidcynodonts and basal sauropodomorph dinosaurs, but the assemblage also includes diagnostic remains of lagerpetid dinosauromorphs, theropods,pterosaurs, basal crocodylomorphs, and stem testudinatans. Several of these groups have also been reported for the Los Colorados Formation(LCF), although the two units differ in their taxonomic content at the species level and in the relative abundance of different taxonomic groups.A comparison of these two faunal assemblage suggest the fauna of QBF is younger than that of LCF and we tentatively assess a late Norian?Rhaetian age for the QBF. Some of the specimens reported here are known from well-preserved specimens and yield important new information for understanding the evolution of these groups, which underscores the relevance of the QBF fauna for assessing the dynamics of the majorgroups of vertebrates that dominated the terrestrial ecosystems during the early Mesozoic in Pangea.","palabras_clave":"TRIÁSICO|BALDE DE LEYES|MARAYES-EL CARRIZAL BASIN|PALEOVERTEBRATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19483,"idioma_id":4,"titulo":"Photoinduced transformation of waste-derived soluble bio-based substances","resumen":"Waste-derived, soluble bio-based substances (SBO), are effective low-cost photosensitizers that couldfind application in pollutant photodegradation. For this reason, it is important to understand if and towhat extent irradiation could modify their properties. The exposure of SBO to simulated sunlight inducedimportant spectral and structural modifications. Both the whole material and its acid-soluble fractionwere characterized, highlighting several properties in common with humic and fulvic substances, includingabsorption spectra, specific absorbance and fluorescence behavior. The latter was described with athree-component model using PARAFAC analysis. Irradiation induced SBO photobleaching, but the absorbanceof the acid-soluble fraction increased with irradiation. This finding suggests a progressivephotochemical solubilization of SBO, which is confirmed by the increase of the carboxylic groups. In additionto absorbance, the fluorescence of whole SBO was also decreased by irradiation, thereby suggestingthat both chromophores and fluorophores were photodegraded. The increasingly hydrophilic charactergiven to SBO by irradiation also accounted for the photoinduced decrease of the surfactant propertiesof the material.","palabras_clave":"PHOTOTRANSFORMATION PROCESSES|BIOWASTE|SOLUBLE BIO-BASED SUBSTANCES|FLUORESCENCE MATRIX"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19484,"idioma_id":4,"titulo":"EXAFS and DFT Study of the Cadmium and Lead Adsorption on Modified Silica Nanoparticles","resumen":"Silica nanoparticles of 7 nm diameter were modified with (3-aminopropyl) triethoxysilane (APTES) and characterized by CP-MAS 13C and 29Si NMR, FTIR, zeta potential measurements, and thermogravimetry. The particles were shown to sorb successfully divalent lead and cadmium ions from aqueous solution. Lead complexation with these silica nanoparticles was clearly confirmed by EXAFS (Extended X-ray Absorption Fine Structure) with synchrotron light measurements. Predicted Pb?N and Pb?C distances obtained from quantum-chemical calculations are in very good agreement with the EXAFS determinations. The calculations also support the higher APTES affinity for Pb2+ compared to Cd2+.","palabras_clave":"Cadmium|Lead|Silica nanoparticles|EXAFS|DFT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19485,"idioma_id":4,"titulo":"Effect of hypothyroidism on the expression of nuclear receptors and their co-regulators in mammary gland during lactation in the rat","resumen":"Thyroid hormones (TH) regulate mammary function. Hypothyroidism (HypoT) has deleterious effects on lactation, litter growth and survival. We analyzed the effect of chronic 6-propyl-2-thiouracil (PTU)- induced HypoT in the expression of nuclear receptors, co-regulators and oxytocin  receptor (OTR) on lactation (L) days 2, 7 and 14. TH receptors (TRs) were increased on L7 at mRNA and protein levels, except TR&#945; protein, that fell on L14. HypoT decreased TR&#945;2 mRNA on L7 and TR&#945;1 protein on L2, while TR&#946;1 protein increased on L14. HypoT increased estrogen receptor &#946; (ER&#946;) mRNA on L7 but decreased its protein levels on L14. Progesterone receptor A (PRA) mRNA decreased fromL2 to L14 while PRB increased, and at proteinlevels PRA levels showed a nadir on L7, while PRB peaked. HypoT decreased PRA mRNA and protein and increased PRB mRNA at L14. Nuclear receptor co-activator (NCOA) 1 and RXR&#945; mRNA showed an opposite pattern to the TRs, while NCOA2 increased at L14; HypoT blocked the variations in NCOA1 and NCOA2. HypoT increased NCOR1 on L2 and decreased OTR at L2 and circulating estradiol and NCOR2 at L14. In controls the most notable changes occurred on L7, suggesting it is a key inflection point in mammary metabolism. The low levels of TR&#945;1, NCOA1 and OTR, and increased NCOR1 produced by HypoT on L2 may hinder the mammary ability to achieve normal milk synthesis and ejection, leading to defective lactation.Later on, altered ER and PR expression may impair further mammary function.","palabras_clave":"mammary gland|hypothyroidism|nuclear receptors|co-regulators|lactation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19486,"idioma_id":4,"titulo":"First microfossil bonebed from the Upper Triassic of the Marayes-El Carrizal Basin, San Juan, Argentina","resumen":"The first Triassic microfossil bonebed found in Argentina is located 80 meters from the top of the Quebrada del Barro Formation in the Marayes-El Carrizal Basin, in the province of San Juan. It consists of specimens from at least 63individuals from an anomalously high concentration of fossils distributed laterally and vertically in a meter-thick fine-grained deposit. Two new taxa from the genera Sphenodontia and Eucynodontia had previously not been found in Argentine Triassic quarries. The bonebed is preserved in a mudflow deposit interbedded with calcic-Argillisols in the medial-distal zone of a distributary fluvial system (DFS). The accumulation is characterized by small-sized skeletal fragments (skulls, jaws and vertebra; all less than 50 mm), low degree of articulation, variable degrees of subaerial exposure, tooth marks, surfacedissolution, and an alkaline authigenic mineral suite. Detailed paleoenvironmental and taphonomic characterization indicate that this accumulation underwent three stages in its taphonomic history: (1) biogenic extrinsic concentration; (2) local transportation and re-deposition by a mudflow on a swampy floodplain; and (3) drying and pedogenesis. Additionally, thedeposit highlights biogenic activity as a way to concentrate a paleofaunal assemblage that likely represents the original community, and mudflow deposits from crevasse splays in DFS as a potential facies for microfossil preservation.","palabras_clave":"Triassic|Norian|Marayes|Microfossil"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19487,"idioma_id":5,"titulo":"CONOCER A LOS INGRESANTES: UNA HERRAMIENTA PARA PENSAR LA PRÁCTICA DOCENTE","resumen":"El trabajo que presentamos es resultado de la investigación ?Estudiantes queingresan al IFDC SL: sus expectativas sobre ser estudiantes?.1Ante la problemática del desgranamiento y abandono de los alumnos en nuestrainstitución nos propusimos indagar las características de estos al ingresar y cuálesson sus ideas sobre lo que implica estudiar una carrera docente, para analizar si hayalguna relación entre estas ideas y las causas del abandono. Conocerlos y saber loque piensan nos posibilitará entre otras cosas, generar acciones que atiendan a surealidad.Aplicamos a los ingresantes a las carreras de: Profesorado en Educación Primaria,y los Profesorados en Educación Secundaria en el año 2011, un cuestionario semiestructurado.Mostramos en este sentido, algunos resultados: una caracterización sociodemográfica y nos centramos en lo que ellos imaginan respecto de las futurasclases en el profesorado.El presupuesto que aparece con fuerza en sus relatos refiere a la idea de esperar?Tener buenos docentes? adjudicándoles un fuerte compromiso y responsabilidaden su tarea, tanto en aspectos relativos a la didáctica como en el vínculointerpersonal.Referimos las diferencias que encontramos entre los profesorados.","palabras_clave":"Formación docente|Alumnos ingresantes|Desgranamiento en educación|Inclusión"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19488,"idioma_id":4,"titulo":"First molecular identification  of Ascocotyle(Phagicola) longain its first intermediate host the mud snail Heleobia australis","resumen":"This is the first study that used species-specific DNA primers to confirm the presence of the heterophyid Ascocotyle (Phagicola) longa Ransom, 1920 in its first intermediate host. The larval stages (rediae and cercariae) of this parasite were morphologicallyand genetically identified in the gonad of the intertidal mud snail Heleobia australis (d?Orbigny, 1835) (Cochliopidae) in the Bahía Blanca estuary, Argentina. In addition, we asked whether the prevalence in H. australis varied between seasons.Mullets ? the second intermediate host of this heterophyid ? migrate in estuaries during the warmer seasons and it is expected that piscivorous birds and mammals ? the definitive hosts prey more intensively on this species at those times. Thus, the numberof parasite eggs released into the tidal flat within their feces should be higher, thereby increasing the ingestion of the parasite by H. australis.We therefore expected a higher prevalence of A. (P.) longa in H. australis in the Bahía Blanca estuary duringspring and summer than autumn and winter. We found that 16 out of 2,744 specimens of H. australis had been infected with A. (P.) longa (total prevalence of 0.58%). Nonetheless, the prevalence showed no significant variation between seasons. Hence, we discuss an alternative scenario where the lack of seasonal changes might be mostly related to the permanent residence of definitive hosts in the estuary and not to the seasonal recruitment of mullets. Finally, we highlight the need for more experimental and comparative approaches in order to understand the diagnosis and geographical distribution of this worldwide heterophyid.","palabras_clave":"Fasciola hepatica|Lepus europaeus|northern Patagonia"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19489,"idioma_id":4,"titulo":"Real-Time Monitoring Distance Changes in Surfactant-Coated Au Nanoparticle Films upon Volatile Organic Compounds (VOCs)","resumen":"We explore into the role of the organic ligands composition surrounding Au nanoparticles (NPs) toward internanoparticles distance changes and film structure during vapor sensing by the use of in situ grazing-incidence small-angle X-ray scattering (GISAXS) and other relevant techniques. We observed distinct changes in core-to-core distance and film structure upon measured concentrations of polar ethanol (EtOH) and nonpolar toluene (Tol) vapors. As-formed tetraoctylammonium bromide (TOABr)-coated Au NPs (SNPs) film exhibited &#8764;0.4 nm core-to-core increase in distance and improved SNPs correlation upon 80% Tol. In the presence of EtOH, SNPs distance seems not to change and correlation critically diminishes, leading to an amorphous film. As-formed films were exchanged with nonanedithiol (NDT) and exposed to 100% Tol vapor. Interestingly, the incorporation of NDT increased distance between NPs and rendered film flexibility. It is determine that just a small number of S, from NDT ligands, binds to Au NPs, and those exchanged alkanedithiol chains adopted a loop conformation around the Au NPs as evidenced by X-ray absorption near-edge structure (XANES) and kink defects by Fourier transformed infrared (FT-IR) experiments, respectively. These findings may solve some fundamental questions about internanoparticle distance-dependent phenomena such as electron transport in chemiresistors and coupling effects in localized surface plasmon resonance (LSPR) solid-state sensors.","palabras_clave":"Au NANOPARTICLES|SAXS|SENSORS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19490,"idioma_id":4,"titulo":"Transit timing variation analysis in southern stars: the case of WASP-28","resumen":"We present four new transit observations of the exoplanet WASP-28b  observed between 2011 August and 2013 October. Employing another 11  transits available in the literature we compute new ephemeris and  redetermine the physical parameters of the star and the exoplanet.  Considering 3 yr of observations, we find no periodic transit timing  variations (TTVs) or long-term variations of the inclination of the  orbit, i, or the depth of the transit, k, that could be attributable to  the presence of another planetary-mass body in the system. We also study  the relations between i and k with different factors that characterize  the light curves. The fits suggest a possible weak correlation between k  with the red noise factor, &#946;, and the photometric noise rate, PNR,  and a weak anticorrelation between i and PNR, although more points are  needed to confirm these trends. Finally, the kinematic study suggests  that WASP-28 is a thin-disc star.","palabras_clave":"TECHNIQUE: PHOTOMETRIC|STARS: INDIVIDUAL: WASP-28|PLANETARY SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19491,"idioma_id":5,"titulo":"Especificidades y características sociodemográficas del barrio Los Artesanos (Córdoba). Notas sobre los resultados del Censo de Vivienda, Hogares, Población y sus características migratorias","resumen":"El propósito de este documento de trabajo es presentar los resultados del Censo de viviendas, hogares, población y sus características migratorias aplicado en el barrio Los Artesanos de la ciudad de Córdoba el sábado 26 de abril de 2014. La realización del censo formó parte de una actividad de extensión del Programa de Investigación Multiculturalismo, migraciones y desigualdad en América Latina del Centro de Estudios Avanzados (UNC) y del Centro de Investigaciones y Estudios sobre Cultura y Sociedad (CONICET y UNC). Esta actividad se desprende de una preocupación que involucra al programa en general y gira en torno a comprender las especificidades de las migraciones regionales recientes en la ciudad de Córdoba. El objetivo principal del censo consistió en elaborar, recopilar y sistematizar datos sobre la cantidad de población residente en el barrio Los Artesanos de la ciudad de Córdoba y sus principales aspectos demográficos, sociales y habitacionales. La idea de la realización de un censo surgió luego de casi dos años de un intenso trabajo etnográfico en el barrio, habitado mayoritariamente por migrantes peruanos, bajo dos motivaciones iniciales: en primer lugar, intereses específicos de investigación vinculados al registro de una serie de datos estadísticos relacionados con las características sociodemográficas de los habitantes de Los Artesanos; en segundo lugar, las propias necesidades de los vecinos del barrio de recabar una serie de datos que les permitan avanzar con ciertos trámites para poder acceder a los títulos de propiedad de esos terrenos y a los servicios públicos.","palabras_clave":"CENSO DE POBLACIÓN|MIGRACIONES INTERNACIONALES|MARGINALIDAD URBANA|CÓRDOBA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19492,"idioma_id":4,"titulo":"Structural style of the Chos Malal fold and thrust belt, Neuqu\u0002en basin, Argentina: Relationship between thick- and thin-skinned tectonics","resumen":"The  Chos Malal fold and thrust belt is a thick-skinned mountain belt that deformed  the Mesozoic deposits of the Neuquén Basin during the Andean orogeny. Four  structural cross-sections across the entire deformed area, supported by field and  subsurface data, suggest a strong link between the thick and thin-skinned  structures. Major Andean thrusts detached ~12 km into the crust produced large  basement wedges, which were inserted in the cover producing minor order  structures. The westernmost of these wedges is exposed forming the Cordillera  del Viento, while a second basement slice was interpreted from seismic lines. Both  thick-skinned structures transferred deformation to the cover along the  Auquilco Formation and contribute to create all the thin-skinned structures  surveyed the fold and thrust belt. We recognized half-graben geometries in the  seismic lines, which preserve their extensional configuration and the main  normal faults are not inverted compressively. Shortenings calculated from the  restoration of the cross-sections are 15.6 km (28%), 15.8 km (28.3%), 14.16 km  (26.5%) and 15.7 km (28.18%) for the north, centrals and south cross-sections  respectively, which evidence a homogeneous contraction during the Andean  orogeny in this segment of the Chos Malal fold and thrust belt.&nbsp; ","palabras_clave":"THICK-SKINNED STRUCTURES|SHORTENING|NEUQUEN BASIN|ANDEAN TECTONICS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19493,"idioma_id":4,"titulo":"Biotic assemblages from Early Cretaceous lacustrine systems in the San Luis Basin, mid-western Argentina","resumen":"Abstract Significant paleobiological data came out from the San Luis Basin (Early Cretaceous, Aptian-Albian from Central Argentina) during the last decades. Two units in this basin include lake paleoenvironments and important fossil content in a mode of excellent preservation that&nbsp; could be considered as Konservatt Lagerstatten deposits. The association of fossil leaves and pollen grains from La Cantera Formation is one of the most ancient and complete record of first angiosperms in South America. The bryophyte association of the same unit constitutes one the most complete record of its type in Argentina. Insects from five different orders were identified in this association, and three endemic species of acuatic insects were described from La Cantera Formation belonging to the Families Notonectidae and Corixidae, including the oldest member of the Anisopinae subfamily. &nbsp;The Pterodaustro guinazui association from Lagarcito Formation is one of the only three fossil associations recorded worldwide from wich it is possible to make studies on the life history parameters of pterosaurs like growth patterns and ontogenetic development. The Pleuropholid fishes from Lagarcito Formation, are the only record of this rare group in Argentina and the second from South America. Despite the amount of paleontological information now available from this area, much work remains to be done on these fossil associations, the correlation between them and the interpretation of its depositional environments. Key words: Early Cretaceous, Aptian- Albian, San Luis Basin, pterosaurs, angiosperms, Notonectidae insects.&nbsp; ","palabras_clave":"ANGIOSPERMS|APTIAN-ALBIAN|EARLY-CRETACEOUS|NOTONECTIDAE INSECTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19495,"idioma_id":4,"titulo":"). Probiotic administration modifies the milk fatty acid profile, intestinal morphology, and intestinal fatty acid profile of goats","resumen":"The effect of a mixture of potentially probiotic bacteria (MPPB; Lactobacillus reuteri DDL 19, Lactobacillus alimentarius DDL 48, Enterococcus faecium DDE 39, and Bifidobacterium bifidum strains) on the milk fatty acid (FA) profile, with emphasis on cis-9,trans-11 conjugated linoleic acid (CLA) in the middle stage of goat lactation, was determined. In addition, the effects of MPPB feeding on the FA profile in intestinal content and intestinal morphology in weaned goats were analyzed. The probiotic supplement was able to modify FA composition of milk and intestinal content. The unsaturated FA concentrations in milk (g of FA\/L of milk) increased from 4.49 to 7.86 for oleic (18:1), from 0.70 to 1.39 for linoleic (18:2), from 0.063 to 0.187 for linolenic (18:3) acid, and from 0.093 to 0.232 for CLA. The atherogenicity index diminished 2-fold after MPPB ingestion. In the intestinal content of the weaned goats, no significant difference in saturated FA concentration compared with the control was observed. However, oleic acid, linolenic acid, CLA, and docosahexaenoic acid concentrations increased by 81, 23, 344, and 74%, respectively, after probiotic consumption. The ruminal production of CLA was increased by the MPPB. However, bacterial strains of MPPB were unable to produce CLA in culture media. By histological techniques, it was observed that the treated group had intestinally more conserved morphological structures than the control group. The results obtained in this study indicate that the MPPB administration in lactating and weaned goats allows for the production of milk with improved concentrations of beneficial compounds, and also produces a protective effect in the goat intestine. The results obtained in this study reinforce the strategy of probiotics application to enhance goat health with the production of milk with higher concentrations of polyunsaturated FA","palabras_clave":"GOAT|FATTY ACID|PROBIOTIC|MILK|CONJUGATED LINOLEIC ACID"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19496,"idioma_id":4,"titulo":"Beneficial properties of residues fermented with goat probiotic on gut health","resumen":"Sugarcane is rich in dietary fibers that have beneficial properties in gastrointestinal tract. In addition the sugarcane is well known for its protective role in mammalian health. However, the sugarcane industry produces vast quantities of residues. Sugarcane blunting (waste produced by the sugarcane industry) was fermented under different conditions: using native microbiota (control), using specific goat probiotics, including Lactobacillus reuteri DDL19 (Treatment Nº1), Lactobacillus alimentarius DDL 48 (Treatment Nº2), Enterococcus faecium DDE 39 (Treatment Nº3), Bifidobacterium bifidum DDBA (Treatment Nº4) and a probiotic mixture containing equal amounts of the four probiotics (Treatment N°5). The fermented sugarcane is a synbiotic supplement for goats because it contains goat probiotic as well as dietary fibers considered as prebiotic. Firstly, the ensilages were microbiologically examined and then administered simultaneously to different batches of six goats each immediately after weaning. We evaluated the five different treatments during three consecutive periods of seven days each (ingest-repose), starting immediately after weaning. The best results were obtained with the probiotic mixtures of strains belonging to different genera and species. The ingestion of the Treatment 5 was able to diminish coliforms and enhance the beneficial Bifidobacterium and lactic acid bacteria by at least one logarithmic unit with respect to the control. Furthermore, the incidence of diarrhea in this experimental group was lower than the control group. The intestinal flora was improved in all cases in which sugar cane fermented with the probiotic strains was consumed. The residue is a good vehicle for probiotic strains, providing sugars and dietary fibers in a period of drought and in geographical areas of poor pastures. In this work, we use an industrial solid waste (highly polluting) as synbiotic supplement food for goats.","palabras_clave":"GOATS   | PROBIOTIC|SILAGE|SUGARCANE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19497,"idioma_id":4,"titulo":"Magnetic End States in a Strongly Interacting One-Dimensional Topological Kondo Insulator","resumen":"Topological Kondo insulators are strongly correlated materials where itinerant electrons hybridize with localized spins, giving rise to a topologically nontrivial band structure. Here, we use nonperturbative bosonization and renormalization-group techniques to study theoretically a one-dimensional topological Kondo insulator, described as a Kondo-Heisenberg model, where the Heisenberg spin-1\/2 chain is coupled to a Hubbard chain through a Kondo exchange interaction in the p-wave channel (i.e., a strongly correlated version of the prototypical Tamm-Schockley model). We derive and solve renormalization-group equations at two-loop order in the Kondo parameter, and find that, at half filling, the charge degrees of freedom in the Hubbard chain acquire a Mott gap, even in the case of a noninteracting conduction band (Hubbard parameter U=0). Furthermore, at low enough temperatures, the system maps onto a spin-1\/2 ladder with local ferromagnetic interactions along the rungs, effectively locking the spin degrees of freedom into a spin-1 chain with frozen charge degrees of freedom. This structure behaves as a spin-1 Haldane chain, a prototypical interacting topological spin model, and features two magnetic spin-1\/2 end states for chains with open boundary conditions. Our analysis allows us to derive an insightful connection between topological Kondo insulators in one spatial dimension and the well-known physics of the Haldane chain, showing that the ground state of the former is qualitatively different from the predictions of the naive mean-field theory.","palabras_clave":"Aislantes Topologicos|Sistemas fuertemente correlacionados|Fase de Haldane|Cadenas de espin"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19498,"idioma_id":4,"titulo":"Applying the technology acceptance model to evaluation of recommender systems","resumen":"In general, the study of recommender systems emphasizes the efficiency of techniques to provide accurate recommendations rather than factors influencing users? acceptance of the system; however, accuracy alone cannot account for users? satisfying experience. Bearing in mind this gap in the research, we apply the technology acceptance model (TAM) to evaluate user acceptance of a recommender system in the movies domain. Within the basic TAM model, we incorporate a new latent variable representing self-assessed user skills to use a recommender system. The experiment included 116 users who answered a satisfaction survey after using a movie recommender system. The results evince that perceived usefulness of the system has more impact than perceived ease of use to motivate acceptance of recommendations. Additionally, users? previous skills strongly influence perceived ease of use, which directly impacts on perceived usefulness of the system. These findings can assist developers of recommender systems in their attempt to maximize users? experience.","palabras_clave":"RECOMMENDER SYSTEMS|EVALUATION|USER ACCEPTANCE|TECHNOLOGY ACCEPTANCE MODEL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19499,"idioma_id":4,"titulo":"Paleodemography of Late Holocene hunter-gatherers from Patagonia (Santa Cruz, Argentina): An approach using multiple archaeological and bioarchaeological indicators","resumen":"Este trabajo enfoca diferentes líneas de investigación a los fines de evaluar la movilidad reducida durante el Holoceno tardío en Patagonia meridional. Se abordan temas de bioarqueología, isótopos estables y de registro arqueológico.","palabras_clave":"PALEODEMOGRAPHY|SALITROSO LAKE|LATE HOLOCENE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19500,"idioma_id":4,"titulo":"Cranial bones and atlas of titanosaurs (Dinosauria, Sauropoda) from Late Cretaceous (Bauru Group) of Uberaba, Minas Gerais State, Brazil","resumen":"  Isolated left prefrontal, left squamosal and atlas of titanosaur dinosaurs are described and compared.  They come from the Late Cretaceous Serra da Galga Member of the Marília Formation at the Serra do  Veadinho region, Peiropolis (Uberaba County, Minas Gerais State, Brazil). Due to the sparse cranial elements  of titanosaurs already known from Brazil, these specimens are noticeable to be presented. In  addition, the atlas vertebra is described for the first time for Brazilian titanosaurs. The morphology of the  cranial bones closely resembles lithostratian titanosaurs, such as Rapetosaurus, rather than basal titanosaurs.  The atlas is similar to that of other titanosaurs, suggesting that the anatomy of this element  seems to be more conservative than other vertebral elements, in which vertebral laminae play an  important rule in titanosaur taxonomy.","palabras_clave":"TITANOSAURIA|LITHOSTROTIA|PEIROPOLIS|PREFRONTAL|SQUAMOSAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19501,"idioma_id":4,"titulo":"Direct analysis of nectar and floral volatile organic compounds in hybrid onions by HS-SPME\/GC-MS: relationship with pollination and seed production","resumen":"In this study, a simple and solvent-free method using headspace solid-phase microextraction (SPME) and gaschromatography?mass spectrometry (GC?MS) was developed for determination of the volatile compoundsfromfresh flowers and nectar of male sterile and fertile lines of Alliumcepa L. The SPME parameters were studied;the optimum conditions of 85 &#956;m carboxen\/polydimethylsiloxane (CAR\/PDMS), extraction temperature of 30 °Cand extraction time of 30 min were obtained. The analytical method was applied to characterize different onionlines according to the chemical composition of the volatile fraction of nectar and flowers. On the other hand, itwas determined which odor components contribute to the pollination of onions lines and relate the content ofspecific analytes with foraging behavior and seed production. More than 90 compounds were identified. Thesamples studied showed differences in the volatile profiles of flowers and nectar among the different lines. Theresults demonstrated that headspace SPME?GCMS is a simple, rapid and solvent-free method suitable foranalysis of volatile compounds emitted from onion plants. Furthermore, a great difference was found for thenumber of bee visits and seed yield among the onion lines analyzed. This study demonstrates that the combinationof chemical information and statistical analysis is able to differentiate onion male sterile lines from fertilelines, as well as among male sterile lines. Repellent compounds, such as dioxolanes, piperidines andorganosulfurs may contribute negatively to pollination, since the higher content of these analytes, the less beevisits and seed production yield.","palabras_clave":"Allium cepa L.|Male-sterility|Solid-phase microextraction (SPME)|Gas chromatography?mass spectrometry (GC?MS)|Volatile organic compounds (VOCs)"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19502,"idioma_id":4,"titulo":"Spatial variability of larval parasites harboured by two crab species in an estuarine environment in Argentina","resumen":"Soft bottom intertidals of the Atlantic SW are dominated by the semi-terrestrial crab Neohelice granulata and the grapsidcrab Cyrtograpsus angulatus. They are similar in size but C. angulatus is mainly a subtidal species, while N. granulata inhabitsthe intertidal zones, thus the two species overlap only during high tides in this area. Since these distribution differencesbetween crab species across the Mar Chiquita Coastal lagoon may affect digenean infection success, the objective of this workis to describe the spatial differences in parasite infection levels and their selectivity on the host. To determine possible spatialdifferences in parasitism levels between sites and crab species across the lagoon, three areas dominated by N. granulata wereselected and adult crabs of N. granulata and C. angulatus were collected. Both crab species harboured metacercariae of thedigeneans Microphallus szidati and Maritrema bonaerensis (Microphallidae), and cystacanths of the acanthocephalanProfilicollis chasmagnathi (Profilicollidae). Digenean species showed preferences between the two crabs. Maritrema bonaerensismean intensity was higher in N. granulata than in C. angulatus, while the opposite trend was found for M. szidati andcould indicate some level of specificity. These results, nevertheless, depended on the study site. For P. chasmagnathi the highestvalues of mean intensity depended more on the site than on the crab species. The values found here, compared with previousworks from both crab species, suggest that besides the spatial heterogeneity, interspecific competition between parasites couldexplain the differences observed.","palabras_clave":"PARASITES|CRABS|ESTUARIES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19503,"idioma_id":4,"titulo":"The Sbi protein contributes to Staphylococcus aureus inflammatory response during systemic infection","resumen":"Staphylococcus aureus is an importanthuman pathogen that causes infections that may present high morbidity andmortality. Among its many virulence factors protein A (SpA) and Staphylococcalbinding immunoglobulin protein (Sbi) bind the Fc portion of IgG interferingwith opsonophagocytosis. We have previously demonstrated that SpA interactswith the TNF-&#945; receptor (TNFR) 1 through each of the five IgG binding domainsand induces the production of pro-inflammatory cytokines and chemokines. TheIgG binding domains of Sbi are homologous to those of SpA, which allow us tohypothesize that Sbi might also have a role in the inflammatory responseinduced by S. aureus. We demonstratethat Sbi is a novel factor that participates in the induction of theinflammatory response during staphylococcal infections via TNFR1 and EGFRmediated signaling as well as downstream MAPKs. The expression of Sbisignificantly contributed to IL-6 production and modulated CXCL-1 expression aswell as neutrophil recruitment to the site of infection, thus demonstrating forthe first time its relevance as a pro-inflammatory staphylococcal antigen in anin vivo model.","palabras_clave":"STAPHYLOCOCCUS AUREUS|SBI|CYTOKINES|INFLAMMATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19504,"idioma_id":4,"titulo":"Numerical Study of the Seismic Efficiency of Buckling-Restrained Braces for Near and Far-Fault Inputs","resumen":"Buckling-restrained braces are commonly installed in building structures as concentric diagonal or chevron braces to protect the main construction from seismic actions. These elements have shown repeatedly their usefulness for reducing the seismic response, both from theoretical and experimental studies; and a number of practical applications havebeen reported. However, seismic records with near-fault effects possess special characteristics that might impair the performance of these devices, similarly as what occurs in base isolation; about energy issues, in such records (containing strong velocity pulses) the energy is delivered in a short time interval, thus being difficult to be absorbed. This work presents a numerical study regarding the performance of buckling-restrained braces under three types of seismic records: corticalfar-field, subductive far-field and near-field (i.e. containing velocity pulses). The study is carried out on a symmetric 4-story steel moment-resisting unbraced frame that was tested at the E-defense laboratory, Japan; the dynamic response of such unbraced bare frame is numerically simulated, obtaining a satisfactory agreement. The same numerical model is used to describe the 2-D dynamic behavior of the steel frame equipped with buckling-restrained braces. The inputs are three series of ten ground motion records; each of these series belongs to one of the three aforementioned types. The average responses for each of the three types of inputs are compared; the obtained results show that the buckling-restrained braces are able to reduce the dynamic response of the frame and that no significant differences can be observed among the efficiencyfor far-fault and near- fault records.","palabras_clave":"BUCKLING|RESTRAINED|BRACES|NEAR-FAULT |RECORDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19505,"idioma_id":4,"titulo":"Polypyridyl ruthenium complexes containing anchoring nitrile groups as TiO2 sensitizers for application in solar cells","resumen":"Ruthenium polypyridyl complexes of general formula [Ru(bpy)3-x(Mebpy-CN)x]2+ ( x = 1,2 and 3, bpy = 2,2´-bipyridine, Mebpy-CN = 4-methyl-2,2´-bipyridine-4´-carbonitrile) can be used as visible dyes in novel solar cells formed with a porous TiO2 film (1 cm2), Pt counter-electrode and iodine\/iodide as the redox mediator electrolyte dissolved in a polymeric matrix. These complexes can be anchored over the surface of nanocrystalline TiO2 through nitrile groups, as evidenced by Raman spectra of the adsorbed species.  Irradiated by a solar simulator (67 mW cm-2), the cells assembled with the Ru complexes with x = 2 and 3 as TiO2 sensitizers exhibit almost identical current-potential curves, with short-circuit photocurrents of 1.25 mA cm-2, fill factors of 0.5 and overall efficiencies around 0.44 %. The Ru complex with x = 1 and the Re complex did not perform as well as sensitizers. These data were consistent with results obtained from quantum efficiency curves and impedance spectra. We conclude that complexes with nitrile groups as anchoring entities are promising candidates for designing efficient DSCCs","palabras_clave":"SOLAR CELLS|RUTHENIUM POLYPYRIDINES|NITRILES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19506,"idioma_id":4,"titulo":"Protein Topology Determines Cysteine Oxidation Fate: The Case of Sulfenyl Amide Formation among Protein Families","resumen":"Cysteine residues have a rich chemistry and play a critical role in the catalytic activity of a  plethora of enzymes. However, cysteines are susceptible to oxidation by Reactive Oxygen  and Nitrogen Species, leading to a loss of their catalytic function. Therefore, cysteine oxidation  is emerging as a relevant physiological regulatory mechanism. Formation of a cyclic  sulfenyl amide residue at the active site of redox-regulated proteins has been proposed as  a protection mechanism against irreversible oxidation as the sulfenyl amide intermediate  has been identified in several proteins. However, how and why only some specific cysteine  residues in particular proteins react to form this intermediate is still unknown. In the present  work using in-silico based tools, we have identified a constrained conformation that accelerates  sulfenyl amide formation. By means of combined MD and QM\/MM calculation we show  that this conformation positions the NH backbone towards the sulfenic acid and promotes  the reaction to yield the sulfenyl amide intermediate, in one step with the concomitant release  of a water molecule. Moreover, in a large subset of the proteins we found a conserved  beta sheet-loop-helix motif, which is present across different protein folds, that is key for sulfenyl  amide production as it promotes the previous formation of sulfenic acid. For catalytic  activity, in several cases, proteins need the Cysteine to be in the cysteinate form, i.e. a low  pKa Cys. We found that the conserved motif stabilizes the cysteinate by hydrogen bonding  to several NH backbone moieties. As cysteinate is also more reactive toward ROS we propose  that the sheet-loop-helix motif and the constraint conformation have been selected by  evolution for proteins that need a reactive Cys protected from irreversible oxidation. Our results  also highlight how fold conservation can be correlated to redox chemistry regulation of  protein function.","palabras_clave":"Cysteine oxidation|Sulfenylamide formation|Structural Bioinformatics|DFTB"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19507,"idioma_id":4,"titulo":"Munroa argentina, a Grass of the South American Transition Zone, Survived the Andean Uplift, Aridification and Glaciations of the Quaternary","resumen":"The South American Transition Zone (SATZ) is a biogeographic area in which not only orogeny (Andes uplift) and climate events (aridification) since the mid-Miocene, but also Quaternary glaciation cycles had an important impact on the evolutionary history of the local flora. To study this effect, we selected Munroa argentina, an annual grass distributed in the biogeographic provinces of Puna, Prepuna and Monte. We collected 152 individuals from 20 localities throughout the species? range, ran genetic and demographic analyses, andapplied ecological niche modeling. Phylogenetic and population genetic analyses based on cpDNA and AFLP data identified three phylogroups that correspond to the previously identified subregions within the SATZ. Molecular dating suggests that M. argentina has inhabited the SATZ since approximately 3.4 (4.2?1.2) Ma and paleomodels predict suitable climate in these areas during the Interglacial period and the Last Glacial Maximum. We conclude that the current distribution of M. argentina resulted from the fragmentation of its once continuous range and that climate oscillations promoted ecological differences that favored isolation by creating habitat discontinuity.","palabras_clave":"Munroa|grasses|SATZ|Quaternary"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19508,"idioma_id":5,"titulo":"Reptiles escamosos (Squamata) del Pleistoceno Medio del Norte de la ciudad de Mar del Plata (provincia de Buenos Aires, Argentina)","resumen":"En este trabajo se describen restos fósiles de dos reptiles escamosos hallados en afloramientos correspondientes al Pleistoceno Medio de los acantilados marinos ubicados al Norte de la ciudad de Mar del Plata (provincia de Buenos Aires). Los especimenes fueron encontradosconformando una tafocenosis junto a restos de otros microvertebrados (anfibios, mamíferos y aves). Los reptiles reconocidos en la asociación están representados por restos de un colúbrido indeterminado y del ánguido Ophiodes sp. Este último hallazgo constituye el primer registrofósil para la familia Anguidae recuperado en en Argentina.","palabras_clave":"FÓSIL|PLEISTOCENO|OPHIODES|`COLUBRIDAE &#769;|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19509,"idioma_id":4,"titulo":"Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase","resumen":"      Breast  cancer is the most common type of cancer in women and represents a major issue  in public health. The most frequent methods to treat these tumors are surgery  and\/or chemotherapy. The latter can exert not only beneficial effects by  reducing tumor growth and metastasis but also toxic actions on normal tissues.  Metronomic therapy involves the use of low doses of cytostatic drugs alone or  in combination to improve efficacy and to reduce adverse effects. We have  previously reported that breast tumors highly express functional muscarinic  acetylcholine receptors (mAChR) that regulate tumor progression. For this  reason, mAChR could be considered as therapeutic targets in breast cancer. In  this paper, we investigated the ability of a combination of the cytostatic drug  paclitaxel plus carbachol, a cholinergic agonist, at low doses, to induce death  in breast tumor MCF-7 cells, via mAChR activation, and the role of  nitric oxide synthase (NOS) and arginase in this effect. We observed that the  combination of carbachol plus paclitaxel at subthreshold doses significantly  increased cytotoxicity in tumor cells without affecting MCF-10A cells, derived  from human normal mammary gland. This effect was reduced in the presence of the  muscarinic antagonist atropine. The combination also increased nitric oxide  production by NOS1 and NOS3 via mAChR activation, concomitantly with an  up-regulation of NOS3 expression. The latter effects were accompanied by a  reduction in arginase II activity. In conclusion, our work demonstrates that  mAChR expressed in breast tumor cells could be a useful target for metronomic  therapy in cancer treatment.   ","palabras_clave":"receptores muscarinicos|cancer de mama|NOS|arginase"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19510,"idioma_id":4,"titulo":"Increasing reports in Mimosa (Mimosoideae, Leguminosae) for the Brazilian Flora","resumen":"Five species of Mimosa (Mimosideae-Leguminosae) for the Brazilian Flora are reported: M. strigillosa, M. leimonias, M. petraea, M. oligophylla, and M. barnebiana. The three first ones are registered from Mato Grosso do Sul, while the remainders are registered from Paraná and Rio Grande do Sul. Descriptions, illustrations, distribution maps and morphologic, geographic and ecological comments are included. Original descriptions of M. petraea and M. leimonias are expanded, Including the fruit characterization.","palabras_clave":"FLORA OF BRAZIL|HABBASIA|MIMOSA|PEDUNCULOSAE|STIPELLARES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19511,"idioma_id":5,"titulo":"Soybean resistance to stink bugs (Nezara viridula and Piezodorus guildinii) increases with exposure to solar UV-B radiation and correlates with isoflavonoid content in pods under field conditions","resumen":"Solar UV-B radiation (280-315nm) has a significant influence on trophic relationships in natural and managed ecosystems, affecting plant-insect interactions. We explored the effects of ambient UV-B radiation on the levels of herbivory by stink bugs (Nezara viridula and Piezodorus guildinii) in field-grown soybean crops. The experiments included two levels of UV-B radiation (ambient and attenuated UV-B) and four soybean cultivars known to differ in their content of soluble leaf phenolics. Ambient UV-B radiation increased the accumulation of the isoflavonoids daidzin and genistin in the pods of all cultivars. Soybean crops grown under attenuated UV-B had higher numbers of unfilled pods and damaged seeds than crops grown under ambient UV-B radiation. Binary choice experiments with soybean branches demonstrated that stink bugs preferred branches of the attenuated UV-B treatment. We found a positive correlation between percentage of undamaged seeds and the contents of daidzin and genistin in pods. Our results suggest that constitutive and UV-B-induced isoflavonoids increase plant resistance to stink bugs under field conditions","palabras_clave":"Glycine max|Hexapoda|Nezara viridula|Piezodorus guildinii"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19512,"idioma_id":4,"titulo":"A new threat for the endangered frog Atelognathus reverberii (Anura: Batrachylidae) in Argentinean Patagonia","resumen":"A new threat for the endangered frog Atelognathus reverberii (Anura: Batrachylidae) in Argentinean Patagonia","palabras_clave":"ANURANS|ARGENTINA|CONSERVATION|MASS MORTALITY|LAGUNA RAIMUNDA FROG"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19513,"idioma_id":4,"titulo":"Examining Mechanisms of Pyrethroid Resistance in Eggs of Two  Populations of the Chagas? Disease Vector Triatoma infestans  (Hemiptera: Reduviidae)","resumen":"Chagas disease is a zoonosis transmitted to man by blood-sucking triatomine bugs found in the Americas. Triatoma infestans (Klug, 1834) is the main vector of Chagas? disease in Argentina. The control of this illness relies heavily on vector control through the use of insecticide. However, resistance to pyrethroid insecticides associated with ineffective field treatments has been increasingly reported in T. infestans from Argentina and Bolivia. There are few reports on the expression and causes of resistance in eggs of resistant populations, and even fewer studies on insecticide resistance throughout embryonic development. In this study, we explore the biochemical and molecular mechanisms potentially associated with the deltamethrin resistance assessed in the developing eggs of the Argentinean (Campo Largo) and Bolivian (Entre Ríos) T. infestans populations.We found measurable activity of monooxigenases and pyrethroid esterases throughout embryonic development. The pyrethroid esterase activity grew steadily throughout development in all the studied populations and was highest in eggs 12 d old. Mean enzyme activity increased from 13.6 to 16.3 and 22.2 picomol 7-hydroxycoumarin\/min (7-OHC) in eggs of 4-, 7-, and 12 d old from the susceptible reference bug colony. Mean activity of resistant populations increased from 16.0 to 25.9 picomol 7-OHC\/min in eggs of 4- to 12 d old in Entre R&#305;´os population, and from 15.9 to 28.9 picomol 7-OHC\/min in Campo Largo population. Molecular analysis of susceptible and resistant developing eggs detected L1014F mutationin both resistant populations, but no L925I mutation was found in any of the studied populations. Higher esterase activity and L1014F presence justify the resistance to pyrethroid throughout developing eggs of both studied T. infestans populations. The description of resistance profiles including resistance mechanisms involved will allow a rational design of campaigns for the control of Chagas disease transmission.","palabras_clave":"TRIATOMA INFESTANS|RESISTANCE|PYRETHROID|EGG|IMMATURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19514,"idioma_id":4,"titulo":"Expressions of E2 and E7-HPV16 proteins in pre-malignant and malignant lesions of the uterine cervix","resumen":"Continuous production of the E7 protein from different types of high risk human papilloma virus(HPV) is required for progression of malignancy. We developed antibodies against HPV type 16E7 and E2 proteins to evaluate their utility as markers for diagnosis during early stages of cervicalcancer. Forty biopsies from uterine cervices were diagnosed as low grade intraepithelial lesion(LSIL), high grade intraepithelial lesion (HSIL), squamous carcinoma (SC), in situ adenocarcinoma(ISA) and invasive adenocarcinoma (AC), all of which were infected with HPV 16. Immunohistochemistrywas used to investigate the expressions of E7 and E2 (both from HPV 16) and p16. P16was expressed in eight of 12 LSILs, in all HSILs, in 16 of 18 SC and in all ACs. E2 was expressedin six of 12 LSILs. E7 was positive in eight of 12 LSILs and in all HSIL and carcinomas. The expressionsof E2 and E7 of HPV16 related to p16 expression confi rmed the value of the viral oncogenicproteins as complementary to histology and support the carcinogenic model of the uterine cervix,because HPVDNA integration into cellular DNA implies the destruction of the gene encoding E2,which suppresses the expression of the E6 and E7 oncoproteins. E2 from HPV16 could be markerfor LSILs, while E7 could be a marker for progression of LSILs to HSILs in patients infected byHPV16, because viral typing has little positive predictive value.","palabras_clave":"ADENOCARCINOMA|BIOMARKERS|PAPILLOMAVIRUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19515,"idioma_id":4,"titulo":"Model for piezoelectric\/ferroelectric composites polarized with interdigitated electrodes","resumen":"A piezoelectric composite homogenization model (PCHM) is presented in this article. A systematic method for predicting the composite macroscopic history-dependent electromechanical response is developed and particularized for piezoelectric fiber composites polarized with interdigitated electrodes. As other composite models, the proposed PCHM requires appropriate constitutive equations describing each pure constituent namely, fiber and matrix. In this work, dielectric matrix is modeled as electromechanically linear while an existing non-linear phenomenological model is used for the fibers. Additionally, a cutting-plane algorithm is developed and implemented to integrate the fibers constitutive equation. The proposed PCHM is implemented in a previously developed ABAQUS\/UEL piezoelectric shell.To evaluate the proposed model, a representative elementary volume (REV) is analyzed with a finite element (FE) model using an ABAQUS\/UEL piezoelectric brick and the same material models for each constituent of the composite. Practical examples are addressed with both, FE\/REV and the proposed PCHM. Electromechanical responses predicted with both approaches are in good agreement. Numerical results illustrate the ability of the proposed PCHM to capture important aspects of piezoelectric devices such as quasi-linear range, as well as both, pressure and electric-field driven depolarization. Finally, a brief convergence analysis is performed indicating an encouraging computational performance of the proposed PCHM.","palabras_clave":"Piezoelectric composite|Interdigitated electrode|Nonlinear|Repolarization|Hysteresis|Cutting-planes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19516,"idioma_id":4,"titulo":"Misregulation effect of a novel allelic variant in the Z promoter region found in cis with the CYP21A2 p.P482S mutation: implications for 21-hydroxylase deficiency","resumen":"The aim of the current study was to search for the presence of genetic variants in the CYP21A2 Z promoter regulatory region in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Screening of the 10 most frequent pseudogene-derived mutations was followed by direct sequencing of the entire coding sequence, the proximal promoter, and a distal regulatory region in DNA samples from patients with at least one non-determined allele. We report three non-classical patients that presented a novel genetic variant?g.15626A>G?within the Z promoter regulatory region. In all the patients, the novel variant was found in cis with the mild, less frequent, p.P482S mutation located in the exon 10 of the CYP21A2 gene. The putative pathogenic implication of the novel variant was assessed by in silico analyses and in vitro assays. Topological analyses showed differences in the curvature and bendability of the DNA region bearing the novel variant. By performing functional studies, a significantly decreased activity of a reporter gene placed downstream from the regulatory region was found by the G transition. Our results may suggest that the activity of an allele bearing the p.P482S mutation may be influenced by the misregulated CYP21A2 transcriptional activity exerted by the Z promoter A>G variation.","palabras_clave":"21-hydroxylase deficiency | molecular genetics|distal Z promoter novel variant|misregulation transcriptional activity."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19517,"idioma_id":4,"titulo":"In-vitro degradation of Czapek and molasses amended post-harvest sugarcane residue by lignocellulolytic fungal strains","resumen":"Post-harvest sugarcane residue (SCR), deposited on sugarcane fields after green harvesting, could serve as a substrate for fungal biomass and lignocellulolytic enzymes production. In the present study, the mycelial growth of six strains (Trametes sp. Y-H11, Bjerkandera sp. Y-HHM2, Phanerochaete sp. Y-RN1, Pleurotus sp. Y-RN3, Myrothecium sp. S-3.20 and Hypocrea nigricans SCT-4.4) was measured in-vitro by applying a modified Gompertz equation. In-vitro assays showed shorter lag phases for fungi in modified Czapek, 0.3% and 1.0% molasses amended post-harvest SCR. Further increments in molasses concentrations produced a reduction on the specific growth rates for all tested fungi. Fungal degradation of post-harvest SCR and the concomitant enzyme production were tested under solid-state fermentation (SSF) of Czapek or molasses amended post-harvest SCR. Under SSF, Pleurotus sp. Y-RN3 produced the highest laccase titers but no hydrolytic activity could be detected. Trametes sp. Y-H11 and Myrothecium sp. S-3.20 showed high endoglucanase activities. Endoxylanase production was detected exclusively in Czapek amended media. These findings have implications for the fungal treatment of post-harvest SCR and its potential impact on the use of these residues in the production of biofuels and ligninolytic enzymes.","palabras_clave":"POST-HARVEST SUGARCANE RESIDUE|MOLASSES|GROWTH MODEL|SOLID-STATE FERMENTATION|DECOMPOSITION|LACCASE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19518,"idioma_id":4,"titulo":"Spatiotemporal expression of Rhomboid domain containing 2 (Rhbdd2) during rat development","resumen":"Over the last few years rhomboid genes have gained interest because of its association with cancer and neurodegenerative diseases. In previous studies, we demonstrated that human RHBDD2 is over-expressed in the advanced stages of breast and colorectal cancers, suggesting a favorable role in cell proliferation. So far little is known about the expression of RHBDD2 in other tissues and other species, and because of similarities between cancer and embryonic cells, this study focused on the evaluation of Rhbdd2 expression in embryonic and adult rat tissues. By IHC and RT-PCR, Rhbdd2 was identified in early stages of most tissues analyzed, with high expression in brain, spinal cord, kidney and embryonic skin. In adult tissues, the expression remained elevated while salivary glands became positive. Furthermore, Rhbdd2 showed a high expression in the most proliferative stages of the rat mammary gland. Indeed, similar findings were observed in the mouse mammary epithelial cell line HC11, in which Rhbdd2 resides in the Golgi apparatus, and at different stages of mouse mammary gland development. Therefore, Rhbdd2 would be implicated in embryonic and adult tissue proliferation.","palabras_clave":"Rhomboid domain containing 2 (Rhbdd2) |embryologic development|rat"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19519,"idioma_id":4,"titulo":"Three-dimensional approach to understanding the relationship between the Plio-Quaternary stress field and tectonic inversion in the Triassic Cuyo Basin, Argentina","resumen":"The Cacheuta sub-basin of the Triassic Cuyo Basin is an example of rift basin inversion contemporaneous to the advance of the Andean thrust front, during the Plio- Quaternary. This basin is one of the most important sedimentary basins in a much larger Triassic NNW-trending depositional system along the southwestern margin of the Pangea supercontinent. The amount and structural style of inversion is provided  in this paper by three-dimensional insights into the relationship between inversion of rift-related structures and spatial variations in late Cenozoic stress fields.  The Plio-Quaternary stress field exhibits important N-S variations in the foreland area of the Southern Central Andes, between 33 and 34 S, with a southward gradually change from pure compression with sigma1 and sigma2 being horizontal, to a strike-slip type stress field with sigma2 being vertical.  We present a 3-D approach for studying the tectonic inversion of the sub-basin master fault associated with strike-slip\/reverse to strike-slip faulting stress regimes. We suggest that the inversion of Triassic extensional structures, striking NNW to WNW, occurred during the Plio?Pleistocene in those areas with strike-slip\/reverse to strikeslip  faulting stress regime, while in the reverse faulting stress regime domain, they remain fossilized. Our example demonstrates the impact of the stress regime on the reactivation pattern along the faults.","palabras_clave":"Structure|Cuyo basin"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19520,"idioma_id":4,"titulo":"A proteome map of a quadruple photoreceptor mutant sustains its severe photosynthetic deficient phenotype","resumen":"Light is the environmental factor that most affects plant growth and     development through its impact on photomorphogenesis and     photosynthesis. A quadruple photoreceptor mutant lacking four of the     most important photoreceptors in plants, phytochromes A and B (phyA,     phyB) and cryptochromes 1 and 2 (cry1, cry2), is severely affected in its     growth and development. Previous evidences suggest that, in addition to     a photomorphogenic disorder, the phyA phyB cry1 cry2 quadruple mutant     might have severe photosynthetic ability alterations. Here we investigated     the photosynthetic processes that are altered in the quadruple mutant     and performed a proteomic profiling approach to identify the involved     proteins.  phyA phyB cry1 cry2 quadruple mutants showed reduced leaf     area and reduced total chlorophyll content. Photosynthetic rates at high     irradiances were reduced about 65% compared to the wild type (WT).     Light saturated photosynthesis and the response of net CO2 exchange to     low and high internal CO2 concentrations suggest that the levels or     activity of the components of the Calvin cycle and electron transport     might be reduced in the quadruple mutant. Consistently, most of the     under expressed proteins in the phyA phyB cry1 cry2 quadruple mutant     had chloroplastic localitation and components of the Calvin cycle and the     light reaction centers were overrepresented. Additionally, Rubisco     expression, the first enzyme responsible for carbon fixation, was three     fold reduced in phyA phyB cry1 cry2 quadruple mutants.    Together these results highlight the importance of phytochrome     and cryptochrome families in the proper autotrophy establishment in     plants and suggest that limitations in Rubisco, the Calvin Cycle and     electron transport  that affects RuBP regeneration reduced photosynthetic     capacity in phyA phyB cry1 cry2 quadruple mutants at high irradiances.","palabras_clave":"Proteoma|Arabidopsis|Fitocromo|Criptocromo|Fotosintesis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19521,"idioma_id":4,"titulo":"A late Miocene Argyrolagidae (Mammalia, Metatheria, Bonapartheriiformes) from northwestern Argentina","resumen":"In this contribution we present the first record of a member of the family Argyrolagidae (Metatheria) recovered from the India MuertaFormation (late Miocene) exposed near San Miguel de Tucumán, Tucumán Province, Argentina. The specimen is represented by a fragment ofright maxilla with M1 ?4 and is referred here as Microtragulus Ameghino. It clearly differs from other members of the genus that preserve theupper dentition. Nevertheless, the impossibility of comparing this material with species only known by lower dentition, such as Microtraguluscatamarcensis (Kraglievich) prevent us from establishing whether this is a new species or not. The comparisons performed allow us to identifycharacters from the upper dentition differing between Microtragulus and Argyrolagus Ameghino. These characters, in turn, led to the reassignmentof a species previously assigned to Microtragulus. The new record reported here, the third known of Microtragulus from northwesternArgentina, broadens the geographic range of the genus, known from the Atlantic coast of Argentina and several localities of the Andean highlandsand the foothills of the cordilleran range","palabras_clave":"Microtragulus|Argyrolagus|Neogene|India Muerta Formation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19522,"idioma_id":4,"titulo":"Carriage of Clostridium perfringens by benthic crabs in a sewage polluted estuary","resumen":"carriage of clostridium perfringens by bethic crabs in a sewage polluted estuary","palabras_clave":"Sewage|Pollution|Clostridium perfringens|Crabs|Monitoring organisms|Indicator bacteria"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19523,"idioma_id":4,"titulo":"Optimization of lactic ferment with quinoa flour as bio-preservative alternative for packed bread","resumen":"The consumers? demand for food with high nutri- tional quality and free of chemical additives increases the need to look for new products and preservation strategies. Quinoa (Chenopodium quinoa) is an Andean pseudocereal highly ap- preciated because of its nutritional properties. Moreover, it is an optimal substrate for growing and production of improved amounts of antifungal compounds by Lactobacillus plantarum CRL 778. The aim of this work was to optimize a lactic ferment for packaged breads with improved nutritional value and prolonged shelf life by applying a statistical exper- imental design model. The addition of 30 % quinoa to the wheat semiliquid ferment (QWF) could highly improve the amino acids release (4.3 g\/L) during fermentation. Moreover, this quinoa proportion was sufficient to obtain the same concentration of the antifungal compounds, phenyllactic and hydroxiphenyllactic acids (PLA and OH-PLA) as with 100 % quinoa (ca. 36 and 51 mg\/L, respectively). Statistical model analysis showed that citrate and skimmed milk en- hanced significantly all evaluated parameters specially PLA (ca. 71 mg\/L), HO-PLA (ca. 75 mg\/L), and lactate (27 g\/L) with a p value <0.005. The synergic effects of higher antifungal compounds production, acid release, and pH decrease allowed lowering the amount (about 50 %) of the chemical preservative calcium propionate commonly added to bread. Moreover, these breads show increased shelf life.","palabras_clave":"quinoa|Lactobacillus plantarum|bread|fermentation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19524,"idioma_id":4,"titulo":"New abelisaurid remains from the Anacleto Formation (Upper Cretaceous), Patagonia, Argentina","resumen":"New theropod remains with abelisaurid affinities from the Upper Cretaceous (Anacleto Formation, lower Campanian), NW Patagonia, Argentina, are here described. The specimen (MPCN-PV 69) consists of a partial premaxilla, fragmentary vertebrae, proximal portion of both humeri, distal portion of the pubis, and an incomplete pedal ungual. Characters linking with Abelisauridae are a premaxilla with a subquadrangular body, externally ornamented, and paradental plates with a striated surface; and humerus with bulbous proximal head, conical internal tuberosity, and reduced greater tubercle. The humerus is similar to those of Carnotaurus and Aucasaurus, due to the presence of a bulbous head and a discontinuity between the head and the internal tuberosity, but also differs from both taxa in the more distal location of the greater tubercle with respect to the internal tuberosity. Aucasaurus also comes from Anacleto Formation, but differences in the humeri suggest that MPCN-PV 69 is a different taxon. The phylogenetic analysis performed supports the affiliation to Abelisauridae, but fails to determinate a more precise relationship with others abelisaurids. However, a majority rule consensus of the analysis shows a position within Brachyrostra. Despite being fragmentary, MPCN-PV 69 probably represents a new abelisaurid from the Anacleto Formation, thus increasing the knowledge and diversity of Late Cretaceous South American abelisaurids.","palabras_clave":"ABELISAURIDAE|THEROPODA|ANACLETO FORMATION|UPPER CRETACEOUS|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19525,"idioma_id":4,"titulo":"Thermogravimetric and Kinetic Analysis of Different Agro-Industrial Wastes Under Nitrogen Atmosphere","resumen":"In this work, the behavior during thermaltreatment processes of marcs, stalk and peach pits, from thewineries, canning and the jam industries was studied.Theimmediate and elemental analysis are realized.The studiedagro-industrial wastes have higher water content than 30%,suggesting that these wastes should be dried before thethermal treatment. The ash contents are smaller than 7%,considering these contents low.The ultimate analysis showedhigher oxygen concentrations present in the studied agroindustrialwastes, decreasing the HHV. The trace elementscontents in these wastes are determined too. These elementsremain in the char\/ash fraction of the different pyrolysisproducts, during thermal treatment under inert atmosphere.Thermal decomposition of the studied wastes was studied ininert nitrogen atmosphere. Their decompositions proceedthrough three stages of weight loss, dehydration, activepyrolysis and passive pyrolysis. The maximum weight losstook place during the active pyrolysis step. In this stage, thepeach pits exhibit the most prominent due to the highercontent of hemicellulose. Another reason can be thedifference of elements concentrations such us the Ca. Thiselement is present in smaller concentration in the peachpits.Themarcs decomposing at lower temperature comparedwith the other biomasses. It also has the lowest mass loss.This behavior might be associated with the highest content ofextractives in its structure. The higher value of activationenergy was obtained for the peach pits, meaning slowerreaction. The reaction orders were smaller than 1 for thestudied agro-industrial wastes.","palabras_clave":"AGROINDUSTRIAL WASTES|OXIDATIVE ATMOSPHERE|THERMAL TREATMENT|THERMOGRAVIMETRIC ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19526,"idioma_id":4,"titulo":"In Vitro infection of human dura-mater fibroblasts with Staphylococcus aureus: colonization and reactive production of IL-1beta","resumen":"Neurol Res. 2015 Jun 24:1743132815Y0000000065. [Epub ahead of print]In Vitro infection of human dura-mater fibroblasts with Staphylococcus aureus: colonization and reactive production of IL-1beta.Almirón MA, Goldschmidt E, Bertelli AM, Gomez MI, Argibay P, Sanjuan NA.AbstractOBJECTIVE:Post-operative meningitis, caused mainly by Staphylococcus aureus and Gram-negative rods, is a life-threatening complication after neurosurgery, and its pathogenesis is far from clear. The purpose of this work was to study the experimental infection of human dura-mater fibroblasts and whole human dura by S. aureus.METHODS:In vitro cultures of human dura-mater fibroblasts and organotypic cultures of small pieces of human dura mater were inoculated with a human-derived S. aureus strain. The pattern of bacterial infection as well as cytokines secretion by the infected fibroblasts was studied.RESULTS:Our results suggest that colonisation of human dura-mater fibroblasts in culture and whole dura-mater tissue by S. aureus includes bacterial growth on the cell surface, fibroblast intracellular invasion by bacteria and a significant synthesis of interleukin 1beta (IL-1beta) by the infected cells.CONCLUSION:This is the first report of human dura-mater fibroblast infection by S. aureus. Hopefully, these results can lead to a better understanding of the pathogenesis of meningitis caused by this bacterial species and to a more rational therapeutic approach.","palabras_clave":"STAPHYLOCOCCUS AUREUS|DURA MATER|HUMAN|FIBROBLASTS|IL-1B"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19527,"idioma_id":4,"titulo":"Influence of the large-scale climate variability on daily rainfall extremes over Argentina","resumen":"A singular value decomposition (SVD) analysis was performed jointly on the daily intensity of extreme rainfall (DIER) over Argentina and sea surface temperature (SST) anomalies from 17.5&#8728;N?90&#8728;S to describe and understand the influence of the large-scale variability of the SSTs on the regional extreme rainfall events for spring summer, autumn and winter. Three main leading modes were identified in agreement with previous works. Mode 1 activity is strongly related to El Niño-Southern Oscillation (ENSO). Warm anomalies in the central-eastern tropical Pacific and western Indian Ocean induce circulation anomalies extended along the South Pacific and the development of a continental-scale circulation gyre in  South America promoting moisture convergence, and in turn favouring DIER positive anomalies, in eastern Argentina. The combined influence of SST anomalies in the tropical Atlantic and western tropical Pacific characterizes Mode 2 activity, which induces an anticyclonic (cyclonic) circulation gyre in southeastern South America promoting anomalous moisture convergence (divergence) and thus positive (negative) DIER anomalies in eastern Argentina in spring and fall (summer and winter). Finally, Mode 3 activity is also influenced by SST anomalies in tropical central-eastern Pacific from winter to summer. The associated teleconnections contribute to the development of a cyclonic circulationmainly influencing southeastern SouthAmerica (SESA) circulation to the north of 30&#8728;S from summer to winter, and further south in spring.","palabras_clave":"LARGE-SCALE CLIMATE VARIABILITY|TROPICAL OCEANS|DAILY PRECIPITATION|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19529,"idioma_id":4,"titulo":"Photoreceptors UVR8 and phytochrome B cooperate to optimize plant growth and defense in patchy canopies","resumen":"      Light is a  critical source of information for plants. Plants use the phytochromes  (particularly phyB) to detect light signals associated with the proximity of  competitors. A low ratio of red (R) to far-red (FR) radiation (R:FR) indicates  increased competition intensity, and triggers morphological responses that  allow the plant to escape shading from its neighbors (the shade avoidance  syndrome, SAS). Recent evidence from studies on light regulation of plant  immunity has suggested that plants may also use ultraviolet-B (UV-B, 290?315  nm) radiation as an indicator of competition intensity and light availability. In  addition, recent studies have shown that UV-B radiation can strongly repress  SAS responses triggered by low R:FR ratios. Ambient UV-B radiation causes  damaging effects on plants, such as DNA damage, and also induces adaptive  photomorphogenic responses acting through a speci&#64257;c UV-B photoreceptor (UVR8). Therefore, the  possibility exists that plants integrate information perceived by phyB and UVR8  to make decisions about growth and defense when faced with a complex light  environment, such as the one that characterizes vegetation canopies. In this  Letter, we address this possibility and discuss how the interplay between UV-B  and R:FR signaling &#64257;ne  tunes plant growth and defense to optimize resource utilization in patchy canopy  environments.     ","palabras_clave":"UVR8|phyB|UVB|R:FR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19530,"idioma_id":4,"titulo":"'Cooperative nucleation modes in polycrystalline CoxPd1-x nanowires'","resumen":"Polycrystalline CoxPd1-x (x = 1, 0.60, 0.45, 0.23, and 0.11) cylindrical nanowires (ø = 18-35 nm, about 1 µm lenght) are produced by AC electrodeposition into hexagonally ordered alumina pores. Single-phase nanowires of an fcc Co-Pd solid solution, with randomly oriented equiaxed grains (7-12 nm) are obtained; in all the cases, the grain size is smaller than the wire diameter. The coercive field and the reduced remanence of Co-rich nanowire arrays are hardly sensitive to temperature within the range varying from 4 K to 300 K. On the other hand, in Pd-rich nanowires both magnitudes are smaller and they largely increase when cooling below 100 K. This behavior also depends on the mean grain size. These facts are systematized considering two main aspects: the non-trivial temperature and composition dependence of the crystalline anisotropy and the saturation magnetostriction in Co-Pd alloys; and a random anisotropy effect, which defines a nucleation localization length that may involve more than a single grain, and thus promotes more cooperative nucleation modes.","palabras_clave":"FABRICATION OF MAGNETIC NANOSTRUCTURES|MAGNETIC PROPERTIES OF NANOSTRUCTURES|MAGNETIZATION REVERSAL MECHANISMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19531,"idioma_id":4,"titulo":"Design challenges in contact plans for disruption-tolerant satellite networks","resumen":"During the past 20 years, space communications technologies have shown limited progress in comparison to Internet-based networks on Earth. However, a brand new working group of the IETF with focus on DTN promises to extend today´s Internet boundaries to embrace disruptive communications such as those seen in space networks. Nevertheless, several challenges need to be overcome before operative DTNs can be deployed in orbit. We analyze the state of the art of effective design, planning, and implementation of the forthcoming network communications opportunities (contacts). To this end, different modeling techniques, system constraints, selection criteria, and methods are reviewed and compared. Finally, we discuss the increasing complexity of considering routing and traffic information to enrich the planning procedure, yielding the need to implement a contact plan computation element to support space DTN operation.","palabras_clave":"DELAY TOLERANT NETWORKS|SATELLITE NETWORKS|CONTACT PLAN DESIGN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19532,"idioma_id":4,"titulo":"Optimization of Lookup Schemes for Flow-Based Packet Classification on FPGAs","resumen":"Packet classification has become a key processing function to enable future flow-based networking schemes. As network capacity increases and new services are deployed, both high throughput and reconfigurability are required for packet classification architectures. FPGA technology can provide the best trade-off among them. However, to date, lookup stages have been mostly developed as independent schemes from the classification stage, which makes their efficient integration on FPGAs difficult. In this context, we propose a new interpretation of the lookup problem in the general context of packet classification, which enables comparing existing lookup schemes on a common basis. From this analysis, we recognize new opportunities for optimization of lookup schemes and their associated classification schemes on FPGA. In particular, we focus on the most appropriate candidate for future networking needs and propose optimizations for it. To validate our analysis, we provide estimation and implementation results for typical lookup architectures on FPGA and observe their convenience for different lookup and classification cases, demonstrating the benefits of our proposed optimization.","palabras_clave":"Data networks|Packet classification|FPGA|Lookup schemes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19533,"idioma_id":4,"titulo":"Enhanced degree of polymerization of methacrylate and epoxy resins  by plasmonic heating of embedded silver nanoparticles","resumen":"Silver nanoparticles (Ag NPs) were synthesized in situ in light-cured methacrylate and epoxy resins. TheUV?vis spectra of the colloidal suspensions displayed an intense surface plasmon resonance band inthe wavelength range 350?550 nm with an absorption peak at 415 nm. Suspensions containing differ-ent amounts of Ag NPs were photopolymerized by UV irradiation. Cylindrical specimens of the resultingnanocomposites (10-mm diameter × 1-mm thickness) were irradiated with a 420-nm LED source whilethe temperature evolution was monitored. The heat released by the Ag NPs under irradiation at theplasmon-resonant wavelength increases the temperature of the surrounding medium. The tempera-ture reached in a methacrylate-based nanocomposite containing 0.03 wt% Ag NPs was 100&#9702;C after 250 sirradiation. This increases the mobility of the reaction environment and, consequently, induces the poly-merization of the unreacted monomer. Moreover, the degree of polymerization of films prepared froman epoxy resin containing 0.02 wt% Ag NPs was 35%, and then increased up to 75% after 10 min irradiationat 420 nm. In practice, the post-curing of partially cured polymers is commonly carried out by thermaltreatments. Results obtained in this study show that the use of a small amount of Ag NPs, as controlledsources of heat under light irradiation, is an attractive strategy to post cure methacrylate and epoxy resinsin the absence of external heating.","palabras_clave":"SILVER NANOPARTICLES|PLASMONIC HEATING|POST-CURING|PHOTOPOLYMERIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19534,"idioma_id":4,"titulo":"Photoluminescent SBA-16 Rhombic Dodecahedral Particles: Assembly, Characterization, and ab Initio Modeling","resumen":"Nowadays, the use of polyhedral instead of spherical particles as building blocks of engineering new materials has become an area of particular effort in the scientific community. Therefore, fabricating in a reproducible manner large amounts of uniform crystal-like particles is a huge challenge. In this work we report a low reagent-consuming binary surfactant templated method mediated by a hydrothermal treatment as a facile and controllable route for the synthesis of crystal-like rombdodecahedral particles exhibiting SBA-16 mesoporosity. It was determined that the hydrothermal treatment conditions were a key point upon the final material morphology, surface area, microporosity, wall thickness, and mesopore width. As a consequence of their internal mesoporosity order, rhombic dodecahedral synthesized particles exhibited highly efficient ultraviolet absorptions and photoluminescence emissions at room temperature. Conducting experimental and theoretical comparative studies allowed us to infer that the presence of intrinsic defects confined into an ordered mesoporous structure plays a very important role in semiconductor materials. The information presented here is expected to be useful, giving new, accurate information, for the construction of novel technological devices.","palabras_clave":"Rombdodecahedral particles|Ab initio modeling|SBA-16|Photoluminescence emissions"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19535,"idioma_id":4,"titulo":"Socio-economic dynamics and innovative technologies affecting health-related lipid content in diets: Implications on global food and nutrition security","resumen":"The recent increase in human population coupledwith rural-to-urban migration has led to challenges in managinga balanced diet in both food ?secure? and food ?insecure? regions. As a result of this geographic phenomenon,the human population continues to suffer fromcaloric-related conditions and diseases, including obesity and coronaryheart diseases. In addition, fat and fatty acid composition of the diet has come under severe attack fromthemedia and different human nutrition corridors in the past as they have been implicated in aiding the increase incases of coronary heart diseases despite their important roles in cellular functions. In this view, fat and fatty acidsis of great significance to the modern society, which aims at balancing their dietary proportions for efficient functionalityof the human body systems. To improve food and nutrition, understanding the physiological function ofthe body and biochemical function of the fatty acids and polar lipids and getting a clearer view of the socioeconomicaspects surrounding food consumption is also important. However, to further enhance the utilisationof fats accessed from diets, it is important to highlight significant current innovative technologies used to improvefood fatty acid profiles and the influence of media on dietary and food consumption patterns. This reviewdiscusses the significance of health-related fatty acids, socio-economic aspects governing their presence in foodand consumption, and howall these factors have a bearing on achieving the goal of human health, well-being andfood and nutrition security.","palabras_clave":"CORONARY HEART DESEASES|FOOD SECURITY|FOOD SECURITY REGIONS|POLAR LIPIDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19536,"idioma_id":4,"titulo":"HOLOCENE PALEOENVIRONMENTAL EVOLUTION IN THE TAFÍ VALLEY (NW ARGENTINA): CLIMATE CHANGE AND HUMAN INTERVENTION","resumen":"The Holocene evolution of the arid and semiarid valleys of NW Argentina is little known. This contribution presents the results of a detailed geomorphological, archaeological, and sedimentary analyses of three representative ephemeral streams located in Tafí Valley. Our objectives were (a) to collect all scattered antecedents about the Tafí?s Holocene and related areas; (b) to present new information obtained from the analysis of two small basins located on the eastern side of Loma Pelada; (c) to develop a paleoenvironmental evolutionary model of the area, considering natural and anthropic factors; (d) to  locate the data set chronologically; and (e) to relate the obtained information to regional and global paleoenvironmental data. The study made it possible to determine four aggradational\/degradational cycles indicating alternating wet-dry conditions. The first cumulative phase (ca.10000-4200 BP) had higher development. After an incision period, a new aggradative phase was developed (before 2500 BP to ca. 1500 AD), covering two Prehispanic periods: Formative and Regional Developments. The last two aggradational\/degradational phases belonged to the LIA and Present Warm Period. This succession was interpreted as a consequence of rapid climatic changes, associated with different regional and global paleoclimatic proxies, and environmental over exploitation pressure exer ted during stage 3.","palabras_clave":"Holocene|Geoarchaeology|Semiarid|Paleoenvironmental Reconstruction"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19537,"idioma_id":4,"titulo":"GEOMORPHOLOGICAL DYNAMIC CHANGES DURING THE HOLOCENE THROUGH EPHEMERAL STREAM ANALYSES FROM NORTHWEST ARGENTINA","resumen":"The records of the Holocene evolution have great importance in the present landscape of the Northwest Argentina. This paper addresses the study of the changes in the geomorphological dynamics recorded in 18 ephemeral streams located on the east side of the Loma Pelada. (Tafi Valley). The records show a coupled system of slope-terrace-alluvial fans resulting from the environmental changes of four alternating aggradation\/degradation stages. The chronology that enables the reconstruction of the system is based on 14C and TL datings, as well as the presence of interstratified volcanic ashes with known ages. The older stage (4) was generated by climatic causes and covers Early to Mid-Holocene (ca. 13000-10000 BP to ca. 4200 BP). After the incision of these accumulations, a new aggradative stage (3) was triggered by anthropic activity occurring from just before 2500 BP to the 15th century. During this time period human occupations were intense in the Tafí Valley (Formative and Regional Development Periods). Lastly, the two recent phases (2 and 1) are related with the climatic variability of the LIA and the Present Warm Period. The application of this methodology opens a new opportunity to learn about changes in Holocene geomorphological dynamics in the semiarid valleys of NW Argentina.","palabras_clave":"Holocene|geoarchaeology|human impact|evolutionary model"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19538,"idioma_id":5,"titulo":"Polynomial Functions Resulting from the Multiplication of Curves in the Framework of the Research and Study Paths","resumen":"This paper presents the results of a research, which proposes the introduction of the teaching by Research and Study Paths (RSPs) into Argentinean secondary schools within the frame of the Anthropologic Theory of Didactics (ATD). The paths begin with the study of Q0: How to operate with any curves knowing only its graphic representation and the unit of the axes?, which was implemented for two consecutive years by 14-17 year-old students. The results of part of the paths that allows the study of the polynomial functions in the frame of RPS are hereby described. These results justify the introduction of a new pedagogy into schools as proposed by Yves Chevallard in order to study Mathematics in conventional courses of Secondary Education schools in Argentina. The scopes relative to the attitudes of the students, which are necessary to face a questions-based education, are outlined in this work.","palabras_clave":"Anthropologic Theory of Didactics (ATD)|Research and Study Paths (RSPs)|Polynomical functions|Secondary school"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19539,"idioma_id":5,"titulo":"La casa propia, un fenómeno en extinción. La 'inquilinización' en la Ciudad de Buenos Aires","resumen":"En los últimos años, el alquiler formal e informal en la ciudad de Buenos Aires se ha convertido en una estrategia residencial empleada por los hogares de las capas medias y bajas para acceder a una vivienda. Este fenómeno se refleja en las estadísticas, pues en el año 2001 la población inquilina constituyo un 22,2% y hacia el 2010 aumento a un 30%.Ante este escenario, el artículo propone abordar el proceso de inquilinización que toma fuerza durante la última década y toma en cuenta las características de la población involucrada y el rol del Estado y del mercado. Se utilizan datos estadísticos tomados del Censo Nacional de Población, Hogares y Vivienda 2001 y 2010 y la Encuesta Permanente de Hogares (Instituto Nacional de Estadísticas y Censos [Indec], 2010; 2012) como fuentes secundarias y primarias (datos testimoniales), con un enfoque de tipo cualitativo para interpretar los significados y las características que están detrás del fenómeno.","palabras_clave":"ALQUILER FORMAL|ALQUILER INFORMAL|DÉFICIT HABITACIONAL|CIUDAD DE BUENOS AIRES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19540,"idioma_id":4,"titulo":"Isolation of cellulolytic bacteria from the intestine of Diatraea saccharalis larvae and evaluation of their capacity to degrade sugarcane biomass","resumen":"As a strategy to find efficient lignocellulose degrading enzymes\/microorganisms for sugarcane biomass pretreatment  purposes, 118 culturable bacterial strains were isolated from intestines of sugarcane-fed larvae of the moth Diatraea  saccharalis. All strains were tested for cellulolytic activity using soluble carboxymethyl cellulose (CMC) degrading  assays or by growing bacteria on sugarcane biomass as sole carbon sources. Out of the 118 strains isolated thirty eight  were found to possess cellulose degrading activity and phylogenetic studies of the 16S rDNA sequence revealed that all  cellulolytic strains belonged to the phyla &#947;-Proteobacteria, Actinobacteria and Firmicutes. Within the three phyla,  species belonging to five different genera were identified (Klebsiella, Stenotrophomonas, Microbacterium, Bacillus and  Enterococcus). Bacterial growth on sugarcane biomass as well as extracellular endo-glucanase activity induced on  soluble cellulose was found to be highest in species belonging to genera Bacillus and Klebsiella. Good cellulolytic  activity correlated with high extracellular protein concentrations. In addition, scanning microscopy studies revealed  attachment of cellulolytic strains to different sugarcane substrates. The results of this study indicate the possibility to  find efficient cellulose degrading enzymes and microorganisms from intestines of insect larvae feeding on sugarcane  and their possible application in industrial processing of sugarcane biomass such as second generation biofuel  production.","palabras_clave":"bacterial symbionts|cellulase| endo-glucanase activity| gut microbiota"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19541,"idioma_id":4,"titulo":"'Middle to late Miocene extensional collapse of the North Patagonian Andes (41º30´ - 42º S)","resumen":"The hinterland zone of the North Patagonian Andes between 41° and 43°S constitutes a poorly explored sector ofthe Andes, where no structural studies and scarce geochronological determinations have been carried out. Thispaper focuses on two isolated volcanic sections hosted at the main Andes, in which field evidence indicates acommon synextensional origin. Geochronological data establish that this volcanic event occurred diachronouslyat the innermost sector of the evolving fold and thrust belt, during middle to late Miocene times. Therefore, theevent was briefly coeval and postdated compressive tectonics recognized in the deformational front and correlativeto the last phase of pluton emplacement of the North Patagonian Batholith. Local-scale topographic swathprofiles performed in this work reveal negative topographic anomalies where normal faults were recognized.Moreover, regional swath profiles show not only a conspicuous depressed zone at the hinterland zone, wherethe studied sections are located, but also anomalously high altitudes at the foreland zone. In addition, calculatedorogenic volumes increase in this sector of the fold and thrust belt, which agreeswith recent shortening estimations.These topographic along-strike variations, in association with late Miocene extension following the maincompressive stage in the area, are explained by a supercritical stage of the orogenic wedge that would haveled to focused extension at the innermost sector of the fold and thrust belt.","palabras_clave":"extension|andres patagonicos|mioceno"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19542,"idioma_id":5,"titulo":"Primera cita de Megastigmus zebrinus Grissell de Argentina  (Hymenoptera: Torymidae) asociado a agallas de Leptocybe  invasa (Hymenoptera: Eulophidae)","resumen":"Se cita por primera vez de Argentina la presencia de Megastigmus zebrinusGrissell (Hymenoptera: Torymidae) asociada a agallas de Eucalyptus camaldulensisDehnhardt (Myrtaceae) producidas por Leptocybe invasa Fisher & LaSalle(Hymenoptera: Eulophidae) de la provincia de Buenos Aires. Megastimus zebrinusfue hallada en Australia, su país de origen, y en Sudáfrica.","palabras_clave":"SANIDAD FORESTAL|EUCALYPTUS|ESPECIE EXOTICA|AVISPA DE LA AGALLA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19543,"idioma_id":4,"titulo":"Weak trophic links between a crab-spider and the effective pollinators of a rewardless orchid","resumen":"Sit and wait predators hunting on flowers are considered to be exploiters of plantepollinator mutualisms.  Several studies have shown that plantepollinator interactions can be highly susceptible to the  impact of a third trophic level, via consumptive (direct) and non-consumptive (indirect) effects that alter  pollinator behavior and, ultimately, plant fitness. However, most flowering plants attract a wide array of  flower visitors, from which only a subset will be effective pollinators. Hence, a negative effect of an  ambush predator on plant fitness should be expected only when: (i) the effective pollinators are part of  the predators´ diet and\/or (ii) the non-consumptive effects of predator presence (e.g. dead prey) alter the  behavior of effective pollinators and pollen movement among individual plants. We analyzed the direct  and indirect effects of a crab-spider (Misumenops pallidus), on the pollination and reproductive success of  Chloraea alpina, a Patagonian rewardless orchid. Our results indicate that most of the flower visitors do  not behave as effective pollinators and most effective pollinators were not observed as prey for the crabspider.  In terms of non-consumptive effects, inflorescences with and without spiders and\/or dead-prey  did not vary the frequency of flower visitors, nor pollinia removal or deposition. Hence, it is not surprising  that M. pallidus has a neutral effect on pollinia removal and deposition as well as on fruit and seed  set. Similar to other rewardless orchids, the low reproductive success of C. alpina (~6% fruit set) was  associated with the limited number of visits by effective pollinators. Negative top-down effects of a  flower-visitor predator on plant pollination may not be anticipated without studying the direct and  indirect effects of this predator on the effective pollinators. In pollination systems where effective pollinators  visited flowers erratically, such as in deceptive orchids, we expect weak or no effect of predators  on plant fitness.","palabras_clave":"CHLORAEA ALPINA |DECEPTIVE STRATEGY |FLOWER VISITORS |NON-CONSUMPTIVE EFFECTS|SIT-AND-WAIT PREDATION |THOMISIDAE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19544,"idioma_id":4,"titulo":"Hot spots of mutualistic networks","resumen":"Incorporating interactions into a biogeographical framework may serve to understand how interactions and the services they provide are distributed in space. We begin by simulating the spatiotemporal dynamics of realistic mutualistic networks inhabiting spatial networks of habitat patches. We proceed by comparing the predicted patterns with the empirical results of a set of pollination networks in isolated hills of the Argentinian Pampas. We first find that one needs to sample up to five times as much area to record interactions as would be needed to sample the same proportion of species. Secondly, we find that peripheral patches have fewer interactions and harbour less nested networks - therefore potentially less resilient communities - compared to central patches. Our results highlight the important role played by the structure of dispersal routes on the spatial distribution of community patterns. This may help to understand the formation of biodiversity hot spots.","palabras_clave":"ISLAND BIOGEOGRAPHY |METACOMMUNITIES|NESTEDNESS|POLLINATION|SEED DISPERSAL|SPATIAL NETWORKS|SPECIES-AREA RELATIONSHIP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19545,"idioma_id":4,"titulo":"Chronic postnatal stress induces voluntary alcohol intake and  modifies glutamate transporters in adolescent rats","resumen":"Postnatal stress alters stress responses for life, with serious consequences on the central nervous system (CNS), involving glutamatergic neurotransmission and development of alcohol voluntary intake. Several drugs of abuse, including alcohol and cocaine, alter glutamate transport (GluT). Here, we evaluated effects of chronic postnatal stress (CPS) on alcohol intake and brain glutamate uptake and transporters in male adolescent Wistar rats. For CPS from postnatal day (PD) 7, the pups were separated from their mothers and exposed to cold stress (4ºC) for 1h during 20 days; controls remained with their mothers. Then they were exposed to either voluntary ethanol (6%) or dextrose (1%) intake for 7 days (5-7 rats per group), then killed. CPS: 1) increased voluntary ethanol intake; 2) did not affect body weight gain or produce signs of toxicity with alcohol exposure; 3) increased glutamate uptake by hippocampal synaptosomes in vitro 4) reduced protein levels (Western measurements) in hippocampus and frontal cortex of glial glutamate transporter-1 (GLT-1) and excitatory amino-acid transporter-3 (EAAT-3) but increased glutamate aspartate transporter (GLAST) levels. We propose that CPS-induced decrements in GLT-1 and EAAT-3 expression levels are opposed by activation of a compensatory mechanism to prevent excitotoxicity. A greater role for GLAST in total glutamate uptake to put a stop to enlarged extracellular glutamate levels is inferred. The results also demonstrate that CPS strongly increased intake of ethanol, which had little impact on effects of CPS on brain glutamate uptake or transporters. However, the impact of early life adverse events on glutamatergic neurotransmission may underlie increased alcohol consumption in adulthood.","palabras_clave":"Alcohol|frontal cortex|glutamate transporter|glutamate uptake|hippocampus|postnatal stress"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19546,"idioma_id":4,"titulo":"Colonization and plant growth promotion of tomato by Burkholderia tropica","resumen":"Several diazotrophic Burkholderia species have been described   to exhibit some activities involved in plant growth promotion and   biological control. In this work seedlings of tomato plants were   inoculated with this bacterium in order to study colonization of   different vegetal tissues and plant growth promoting ability under   greenhouse conditions. Tomato seedlings inoculated with Burkholderia tropica strain MTo-293 and two derivative strains containing the marker genes gusA and gfp,   respectively (constructions described in this work), were grown under   gnotobiotic conditions. Colonization was monitored both by colony   counting of bacterial suspensions from homogenized tissues with or   without previous surface disinfection and by microscopic observation of   entire plant tissues. In another set of experiments tomato seedlings   were inoculated with B. tropica MTo-293 for evaluation of   tomato production under greenhouse conditions. Tomato yields were   determined by quantifying total tomato production throughout the crop in   two different seasons. B. tropica could be isolated from root surfaces (&gt;7.0 log&nbsp;CFU&nbsp;g&#8722;1 fresh weight) and from surface-disinfected and disrupted roots (&gt;5.0 log&nbsp;CFU&nbsp;g&#8722;1 fresh weight) and stems (&gt;4.0 log&nbsp;CFU&nbsp;g&#8722;1   fresh weight) of inoculated plants. Microscopic studies showed   colonizing bacteria on root hairs, root tips, lateral root emergence   sites, and stomata. In greenhouse experiments inoculated plants showed a   consistent increase of both number and weight of fruits as compared to   uninoculated controls. Although this enhancement in fruit production was   only statistically significant for fruit weight in the first crop   season, our results show a consistent tendency to a higher yield (5?15%)   for the inoculated treatments also in the second year. These results   show that seedling inoculation with B. tropica led to effective   root colonization of tomato plants followed by bacterial spreading to   aerial tissues. This significant colonization was accompanied by an   enhancement of tomato production in two different crop seasons.","palabras_clave":"Burkholderia|Inoculation|Tomato|Colonization|PGPB"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19547,"idioma_id":4,"titulo":"The E2P-like state induced by magnesium fluoride complexes in the Na,K-ATPase. Kinetics of formation and interaction with Rb+","resumen":"The first X-ray crystal structures of the Na,K-ATPase were obtained in the presence of magnesium and fluoride as E2(K2)Mg?MgF4, an E2&#8729;Pi-like state capable to occlude K+ (or Rb+). This work presents a functional characterization of the crystallized form of the enzyme and proposes a model to explain the interaction between magnesium, fluoride and Rb+ with the Na,K-ATPase. We studied the effect of magnesium and magnesium fluoride complexes on the E1?E2 conformational transition and the kinetics of Rb+ exchange between the medium and the E2(Rb2)Mg?MgF4 state. Our results show that both in the absence and in the presence of Rb+, simultaneous addition of magnesium and fluoride stabilizes the Na,K-ATPase in an E2 conformation, presumably the E2Mg?MgF4 complex, that is unable to shift to E1 upon addition of Na+. The time course of conformational change suggests the action of fluoride and magnesium at different steps of the E2Mg?MgF4 formation. Increasing concentrations of fluoride revert along a sigmoid curve the drop in the level of occluded Rb+ caused by Mg2 +. Na+-induced release of Rb+ from E2(Rb2)Mg?MgF4 occurs at the same rate as from E2(Rb2) but is insensitive to ADP. The rate of Rb+ occlusion into the E2Mg?MgF4 state is 5?8 times lower than that described for the E2Mg?vanadate complex. Since the E2Mg?MgF4 and E2Mg?vanadate complexes represent different intermediates in the E2-P &#8594; E2 dephosphorylation sequence, the variation in occlusion rate could provide a tool to discriminate between these intermediates.","palabras_clave":"complejos de fluoruro y magnesio|Na,K-ATPasa cristalizada|cambios conformacionales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19548,"idioma_id":4,"titulo":". Male Sexual Behavior and Pheromone Emission Is Enhanced by Exposure to Guava Fruit Volatiles in Anastrepha fraterculus","resumen":"Background: Plant chemicals can affect reproductive strategies of tephritid fruit flies by influencing sex pheromone communication and increasing male mating competitiveness.   Objective and Methodology: We explored whether exposure of Anastrepha fraterculus males to guava fruit volatiles and to a synthetic blend of volatile compounds released by this fruit affects the sexual performance of wild and laboratory flies. By means of bioassays and pheromone collection we investigated the mechanism underlying this phenomenon.  Results: Guava volatile exposure enhanced male mating success and positively affected male calling behavior and pheromone release in lab and wild males. Changes in male behavior appear to be particularly important during the initial phase of the sexual activity period, when most of the mating pairs are formed. Exposure of laboratory males to a subset of guava fruit volatiles enhanced mating success, showing that the response to the fruit might be mimicked artificially.  Conclusions: Volatiles of guava seem to influence male mating competitiveness through an enhancement of chemical and physical signals related to the communication between sexes. This finding has important implications for the management of this pest species through the Sterile Insect Technique. We discuss the possibility of using artificial blends to improve the sexual competitiveness of sterile males.","palabras_clave":"SOUTH AMERICAN FRUIT FLY|PHEROMONE|SEXUAL ENHANCEMENT|MATING COMPETITIVENESS|GUAVA|FRUIT VOLATILES|TEPHRITIDAE|STERILE INSECT TECHNIQUE|SEXUAL COMPETITIVENESS ENHANCERS|HOST PLANT CHEMICALS|PSIDIUM GUAJABA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19550,"idioma_id":4,"titulo":"MODELING OF DEGRADATION KINETIC AND TOXICITY EVALUATION OF HERBICIDES MIXTURES IN WATER USING THE UV\/H2O2 PROCESS","resumen":"The UV\/H2O2 process was applied to the treatment of different mixtures of herbicides in water. Glyphosate, the herbicide most used in the world, was mixed with others hormonal herbicides with residual activity as 2,4-D and dicamba. The main goals of the study were to develop a kinetic model for interpret the simultaneous oxidation of two mixtures (glyphosate plus 2,4-D and glyphosate plus dicamba). The model is based on a complete reaction mechanism, which comprises hydrogen peroxide photolysis and decomposition of both herbicides in each mixture studied. It takes into account the effect of non-uniform distribution of the local rate of absorbed photons. Good agreement of the experimental data and the model is achieved in spite of the differences in the reactivity between glyphosate and 2,4-D (or dicamba). Toxicity assays (employing Vibrio fischeri) were also performed indicating that the toxicity of the mixture of glyphosate and 2,4-D was significantly reduced after the treatment.","palabras_clave":"KINETICS|HERBICIDES MIXTURES|UV\/H2O2 PROCESS|GLYPHOSATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19551,"idioma_id":4,"titulo":"Are seed mass and seedling size and shape related to altitude? Evidence in Gymnocalycium monvillei (Lem.) Britton & Rose (Cactaceae)","resumen":"Several studies reported a negative relationship between altitude and seed mass. In cacti species, seed mass has been also related to seedling morphology (size and shape). Here we studied Gymnocalycium monvillei (Lem.) Britton & Rose, a cactus species with a wide altitudinal distribution, with the main aim of analyzing how altitude affects seed mass and seedling size (height and width) and shape (globose or columnar seedlings). We collected seeds from five sites along the entire altitudinal istribution of the species in Córdoba Mountains (sites were located between 878 and 2230 m a.s.l.), encompassing a marked climatic gradient (6 °C of mean annual temperature difference between the extreme sites). Seed mass and seedling traits were measured in the laboratory. Seedling height increased with altitude, whereas seed mass was not related to this parameter. Seedlings became more globose (reduced surface\/volume ratio) with decreasing altitude. Variation in seedling shape along the altitudinal gradient may be related to the contrasting climatic conditions to which seedlings are exposed, and could account for the wide altitudinal distribution of G. monvillei. Our results highlight the importance of seedling traits in the species response to climatic change.","palabras_clave":"Gymnocalycium|Altitudinal gradients|Seed mass|Seedling morphology|Cactaceae"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19552,"idioma_id":4,"titulo":"Photodynamic Inactivation of Bacteria Using Novel Electrogenerated  Porphyrin-Fullerene C60 Polymeric Films","resumen":"A porphyrin-fullerene C60 dyad (TCP-C60) substituted by carbazoyl groups was used to obtain electrogenerated polymeric films on optically transparent indium tin oxide (ITO) electrodes. This approach produced stable and reproducible polymers, holding fullerene units. The properties of this film were compared with those formed by layers of TCP\/TCP-C60 and TCP\/ZnTCP. Absorption spectra of the films presented the Soret and Q bands of the corresponding porphyrins. The TCP-C60 film produced a high photodecomposition of 2,2-(anthracene-9,10-diyl)bis(methylmalonate), which was used to detect singlet molecular oxygen O2(1&#948;g) production in water. In addition, the TCP-C60 film induced the reduction of nitro blue tetrazolium to diformazan in the presence of NADH, indicating the formation of superoxide anion radical. Moreover, photooxidation of L-tryptophan mediated by TCP-C60 films was found in water. In biological media, photoinactivation of Staphylococcus aureus was evaluated depositing a drop with 2.5 × 103 cells on the films. After 30 min irradiation, no colony formation was detected using TCP-C60 or TCP\/TCP-C60 films. Furthermore, photocytotoxic activity was observed in cell suspensions of S. aureus and Escherichia coli. The irradiated TCP-C60 film produced a 4 log decrease of S. aureus survival after 30 min. Also, a 4 log reduction of E. coli viability was obtained using the TCP-C60 film after 60 min irradiation. Therefore, the TCP-C60 film is an interesting and versatile photodynamic active surface to eradicate bacteria.","palabras_clave":"Organic Polymers|Photodynamic Inactivation|Electropolymerization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19553,"idioma_id":4,"titulo":"Nitrogen balance in Holstein steers grazing winter oats: effect of nitrogen fertilization","resumen":"The present study evaluated the effect of nitrogen (N) fertilization of winter oats on whole-animal N balance (N intake, N excretion in urine and feces, N retention), partition of urinary N (purine-N derivatives and urea-N) and average daily gain (ADG) in grazing steers. The experimental area was divided in two plots (10 steers\/plot), and samples were obtained in two periods (1 plot\/period).The experimental area was divided in 2 plots, and each plot in 10 strips. Twenty Holstein steers (161.3 ± 7 kg of initial body weight) grazed, for 51 days, individual strips of fertilized (100 kg N\/ha; N100) and non-fertilized (N0) winter oats during daylight (10 h\/d). The daily individual grazing paddock was adjusted to offer 6 kg DM of green leaf?100 kg BW-1?d-1. Chemical composition of the herbage and N diurnal variation were estimated by collecting 3 samples per paddock at 8:30, 13:30 and 18:30 h, twice on each sampling period. Forage intake and in vivo digestibility were estimated by the n-alkane technique. Individual N intake was estimated using n-alkane data, the ingestive behavior data and the diurnal variation of the chemical composition of the forage. N fertilization increased N content (P<0.01; N0=11.4% CP vs. N100=13.9% CP) and decreased the water soluble carbohydrate content (P<0.01; N0=21.1% vs. N100=16.8%) in the forage, but did not modify herbage mass or the DM content. Dry matter intake (4.72 kg DM\/d), water intake (7.57 L\/d) and DM digestibility (67%) were not affected by N fertilization. However, N intake and N digestibility were higher in N100 than in N0 (20 vs. 7 g N\/d). While treatments had similar fecal N excretions (aerage 45.4 g N\/d), there was a trend to increase urinary N excretion with N intake (P=0.08; N100=53.3 vs. N0=47.5 g N\/d), a trend to increase N-allantoin excretion (P=0.11; N100=3.18 vs. N0=2.91 g\/d) and an increase in urea-N excretion (P<0.01; N100=30.7 vs. N0=23.8 g\/d). Increasing N intake led to greater N retention (P<0.02; N100=37.9 vs. N0=20.9 g N\/d) and ADG (P<0.03; N100=860 vs. N0=698 g\/d). These results suggest that fertilizing winter oats with 100 kg N\/ha improves N retention and ADG in young steers under grazing conditions.","palabras_clave":"GRAZING|WINTER OATS|NITROGEN BALANCE|STEERS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19554,"idioma_id":4,"titulo":"1H-NMR and isotopic fingerprinting of olive oil and its unsaponifiable fraction. Tracing the geographical origin of virgin olive oils by pattern recognition","resumen":"1H&#61485;NMR spectral data and H and C isotope abundances of virgin olive oils (VOOs) and their unsaponifiable fractions were analysed by pattern recognition techniques, such as principal component analysis (PCA) and partial&#61485;least squares discriminant analysis (PLS&#61485;DA). The aim was to develop chemical tools for the authentication of VOOs according to their geographical origin or Protected Designation of Origin (PDO), as well as to detect the mislabelling of the provenance of VOOs, at the regional or national level, or the mislabelling of non&#61485;PDO oils as PDO VOOs. The relationship between stable isotope abundances of the VOOs and their unsaponifiable fractions and the latitude of the VOO geographical origin was confirmed; but these criteria were not completely discriminant to differentiate VOOs according to their geographical origin. However, delta2H and\/or delta13C data provided complementary geographical information to 1H&#61485;NMR data in the PLS&#61485;DA binary classification models afforded for VOOs from Greece, Spain, Italy, Izmir (Turkey), Crete (Greece), and the PDOs Riviera Ligure (Italy) and Huile d´olive d´Aix&#61485;en&#61485;Provence (France). 2H\/1H and 13C\/12C ratios of the unsaponifiable fractions of VOOs are reported here for the first time. The present approach for PDO Riviera Ligure VOOs, based on 1H&#61485;NMR data and C isotope abundance of the bulk oil and its unsaponifiable fraction, outperformed the previously reported classification models. Moreover, the PLS&#61485;DA models to authenticate VOOs from Greece and detect non&#61485;Greek VOOs achieved over 93 % of correct predictions.","palabras_clave":"NUCLEAR MAGNETIC RESONANCE|UNSAPONIFIABLE FRACTION|OLIVE OIL|GEOGRAPHICAL ORIGIN|CHEMOMETRICS|PATTERN RECOGNITION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19555,"idioma_id":4,"titulo":"Discrimination of four Culex (Culex) species from the Neotropics based on geometric morphometrics","resumen":"Achieving correct identification of Culex species is difficult because many anatomical characters of larvae and females are polymorphic or overlap among distinct species. The overlapping is known to occur between Culex bidens, Cx. interfor, Cx. mollis and Cx. tatoi, from the subgenus Culex. The first three were incriminated in viruses? transmission in Argentina. The purpose was to distinguish between specimens of four species using geometric morphometric procedures. From field and entomological collections, 10 type I and 10 type II landmarks on the wings of females and the dorsomentum of larvae, respectively, were defined. The free morphometric software modules by J.P. Dujardin were used. Landmark coordinates were submitted to Procrustes and TPS analyses to generate size (centroid size, CS) and shape (partial warps, PW) variables. Size analysis was performed by nonparametric comparisons of CS measurements based on permutations, and shape, by submission of PW to discriminant analysis. Re-identification and identification of external specimens were also realized. Wing and Dm shapes gave similar results. The individuals arranged into three groups coinciding with Cx. bidens + Cx. interfor, Cx. mollis and Cx. tatoi. The latter two had a very different wing and Dm shapes. The accurate re-identification was greater than or equal to 77 % in all cases, and the identification of external specimens was achieved for all the species and both structures. Larval characters are more informative than female features. Geometric morphometrics, as a complementary tool, will facilitate identification in junction with others, such as DNA sequence analysis.","palabras_clave":"Taxonomy|Identification|Mosquito|Size"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19556,"idioma_id":5,"titulo":"COMPOSICIÓN Y ACTIVIDAD ANTIFÚNGICA DE ACEITES ESENCIALES DE ESPECIES DE SCHINUS NATIVAS DEL NOROESTE ARGENTINO","resumen":"Introducción: La familia Anacardiaceae comprende 60 géneros y 600 especies distribuidas principalmente en el trópico y subtrÓpico. Entre ellas están especies de Schinus autóctonas del noroeste argentino. Los frutos y hojas de las mismas contienen aceites esenciales, de composición y actividad biológica desconocida. Objetivos: 1) Caracterizar la composición de los aceites esenciales de especies del genero Schinus; 2) Determinar actividad fungicida y\/o fungistática de los mismos sobre hongos toxigénicos del género Fusarium causantes de podredumbres en cereales. Materiales y Métodos: Hojas y frutos de las especies de Schinus se recolectaron en Tafi del Valle (S. gracilipes), y Ampimpa (S. areira y S. fasciculatus), obteniéndose los aceites por arrastre con vapor. La composición de aceites esenciales de hojas de Schinus areira (Sal) y frutos de S. areira (Saf), S. fasciculatus (Sff) y S. gracilipes (Sgf) se analizaron mediante cromolitografía gaseosa acoplada a espectrometría de masas. La actividad antifúngica de los 4 aceites se determinó mediante ensayos de microdilución en medio YES semilíquido sobre F. graminearum y F. verticillioides, estableciéndose la mínima concentración necesaria para inhibir el 100% (MIC100) de crecimiento fúngico. Las medias de MIC100 y de contenidos de constituyentes de aceites esenciales se sometieron a análisis de componentes principales. Resultados y Discusión: Los principales constituyentes identificados fueron sabineno (26,0+\/-0,5%), biciclogermacreno (14,5+\/-0,4%), E-citral (6,7+\/-0,2%) en Sal; limoneno (27,7+\/-0,7%), sabineno (16,0+\/-0,5%), a-felandreno (14,6+\/-0,8%), y biciclogermacreno (8,1+\/-0,2%) en Sff; y a-pineno (25,4+\/-0,8%), b-pineno (24,7+\/-0,7%) y sabineno (13,6+\/-0,4%) en Sgf. Entre los aceites ensayados, el de Sff tuvo la mayor actividad antifúngica con MIC100 (F. graminearum) = 6 por mil y MIC100 (F. verticillioides) = 12 por mil. El análisis de componentes principales sugiere que 9 constituyentes (a-tuyeno, a-terpineno, p-cimeno, &#978;-terpineno, terpinoleno, 1-terpineol, a-calacoreno, a-felandreno y terpinen-4-ol) explican el mayor efecto antifúngico de Sff. Las MIC100s de los aceites de Schinus fueron en promedio 30-60 y 8,5-17 veces mas elevadas que aquellas obtenidas para el aceite de timol sobre F. verticillioides y F. graminearum, respectivamente. En el caso de los fungicidas comerciales, sus MIC100s fueron 3 ordenes de magnitud menores que las de los aceites de Schinus. Conclusiones: Los aceites esenciales obtenidos de las especies de Schinus demostraron un alto porcentaje de mono y sesquiterpenos hidrocarbonados. La actividad inhibitoria de estos aceites fue fungistática sobre el crecimiento de F. verticillioides y F. graminearum y bastante mas baja que la observada para el aceite de tomillo y los fungicidas comerciales ensayados.","palabras_clave":"ACEITES ESENCIALES|SCHINUS|ACTIVIDAD ANTIFUNGICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19557,"idioma_id":5,"titulo":"ESPECIES DE NATIVAS DE SCHINUS: ACTIVIDAD ANTIFÚNGICA DE SUS ACEITES ESENCIALES EN MEZCLAS CON FUNGICIDAS COMERCIALES","resumen":"Especies de Fusarium generan podredumbres en espigas de maíz y trigo, contaminando los granos con micotoxinas tóxicas para humanos y animales. El uso de productos naturales es una de varias estrategias que podrían emplearse en el control de estos hongos. Los aceites esenciales de especies del género Schinus, al ser ensayados separadamente, demostraron una actividad antifúngica moderada sobre especies toxigénicas de Fusarium. El objetivo de este trabajo fue determinar el efecto de aceites esenciales de especies de Schinus nativas del noroeste argentino al ser ensayadas en mezclas con fungicidas comerciales. Los aceites esenciales de hojas de Schinus areira (Sal) y frutos de S. areira (Saf), S. fasciculatus (Sff) y S. gracilipes (Sgf) se ensayaron en mezclas con epoxiconazol o piraclostrobin. La actividad antifúngica se determinó mediante ensayos de microdilución en medio YES semilíquido sobre F. graminearum y F. verticillioides, empleando un diseño de tablero de ajedrez. Se determinaron las mínimas concentraciones necesarias para inhibir el 100% (MIC100) de crecimiento fúngico. Los valores de MIC100 se utilizaron para calcular los índices de concentración inhibitoria fraccionaria (FICI), determinándose si la interacción era sinérgica (FICI &#8804; 0,5), aditiva (FICI 0,5-4,0) o antagónica (FICI > 4,0). Los FICI de las mezclas estuvieron comprendidos entre 2,5-3,9 (aceites esenciales-piraclostrobin) y 2,5-4,0 (aceites esenciales-epoxiconazol) para F. verticillioides; y de 2,6-4,0 (aceites esenciales-piraclostrobin) y 3,0-4,0 (aceites esenciales-epoxiconazol) para F. graminearum. Los valores de FICI obtenidos indicaron que el efecto conjunto de aceites esenciales de Schinus-fungicidas fue aditivo sobre F graminearum y F. verticillioides. Esta situación sugiere que los aceites actuaron a través de mecanismos de acción diferentes al de los fungicidas comerciales ensayados. Los resultados indican que puede reducirse las dosis de fungicidas requeridas para el control de las especies de Fusarium cuando se los ensaya en mezclas con aceites de Schinus.","palabras_clave":"SCHINUS|ACTIVIDAD ANTIFUNGICA|ACEITES ESENCIALES|FUNGICIDAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19558,"idioma_id":4,"titulo":"Comparative analysis of zygotic developmental genes in Rhodnius prolixus genome shows conserved features on the tracheal developmental pathway","resumen":"Most of the in-depth studies on insect developmental genetic have been carriedout in the fruit fly Drosophila melanogaster, an holometabolous insect, so muchmore still remains to be studied in hemimetabolous insects. Having Rhodniusprolixus sequenced genome available, we search for orthologue genes of zygoticsignaling pathways, segmentation, and tracheogenesis in the R. prolixus genomeand in three species of Triatoma genus transcriptomes, concluding that there is ahigh level of gene conservation. We also study the function of two genes requiredfor tracheal system development in D. melanogaster - R. prolixus orthologues:trachealess (Rp-trh) and empty spiracles (Rp-ems). From that we see that Rp-trhis required for early tracheal development since Rp-trh RNAi shows that theprimary tracheal branches fail to form. On the other hand, Rp-ems is implied inthe proper formation of the posterior tracheal branches, in a similar way toD. melanogaster. These results represent the initial characterization of thegenes involved in the tracheal development of an hemimetabolous insect building abridge between the current genomic era and V. Wigglesworth´s classical studies oninsects´ respiratory system physiology.","palabras_clave":"Rhodnius prolixus|Tracheogenesis|Trachealess|Empty spiracles|Developmetal genes"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19559,"idioma_id":4,"titulo":"Amelioration of mercury nephrotoxicity after pharmacological manipulation of organic anion transporter 1 (Oat1) and multidrug associated resistance protein 2 (Mrp2) with furosemide","resumen":"Inorganic mercury is a major environmental contaminant. The primary site of mercury-induced injury is the kidney due to the uptake of Hg(2+)-conjugated organic anions in the proximal tubule, primarily across the organic anion transporter 1 (Oat1) at the basolateral membrane. At the luminal side, mercuric ions are eliminated by the multidrug resistance-associated protein 2 (Mrp2). It was demonstrated that furosemide treatment induces up-regulation of Oat1 renal expression. As novel preventive and therapeutic strategies based on pharmacological manipulation of drug transporters are emerging, this study was designed to evaluate the impact of furosemide modulation of Oat1 on the nephrotoxicity induced by HgCl2. Wistar rats were treated with furosemide (6 mg per 100 g per day, s.c.) for 4 days or with HgCl2 (4 mg kg&#8722;1, i.p.) 18 h before the experiments or with furosemide for 4 days before the HgCl2 injection. Furosemide treatment improved HgCl2-induced tubular injury as assessed by urinary alkaline phosphatase activity, urinary glucose, Oat5 urinary excretion and histopathological studies. Besides, administration of furosemide enhanced urinary excretion of mercury, reduced mercury total renal accumulation and increased Mrp2 renal expression. In summary, furosemide improves HgCl2-induced proximal tubule injury up-regulating mercury transporters, thus increasing renal elimination of the mercuric ions. Hence, pharmacological manipulation of mercury transporters with furosemide might be a preventive strategy to reduce mercury toxicity.","palabras_clave":"MERCURIC CHLORIDE|FUROSEMIDE|ACUTE KIDNEY INJURY|MRP2|OAT1"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19560,"idioma_id":5,"titulo":"Curricularizando la extensión. Entramado de encuentros, aprendizajes y derechos","resumen":"Desde el año 2008 la cátedra de Educación y Comunicación Alimentario Nutricional implementa una estrategia de curricularización de la extensión, centrada en un abordaje comunitario de problemáticas alimentario-nutricionales, desde una perspectiva de promoción de la salud y construcción de ciudadanía. A partir de la indagación de las representaciones y prácticas alimentarias de los participantes de instituciones y organizaciones comunitarias de un barrio de la ciudad de Gualeguaychú, se han concretado acciones comunitarias desde la perspectiva de la educación y la comunicación popular en salud colectiva. En el abordaje se han tenido presentes la participación real de los destinatarios y la construcción colectiva de conocimiento, tanto en la identificación de situaciones problemáticas de la realidad, como de estrategias de acción para superarlas.Esta forma de trabajo ha implicado el desarrollo de acciones de extensión articuladas conla docencia. Seofrece a las\/os estudiantes instancias que permiten la sensibilización y la formación, en educación y comunicación popular en salud, con Jóvenes y Adultos a través de la intervención comunitaria, interpelando su formación profesional. Se dinamizan estrategias pedagógicas y epistemológicas que faciliten la construcción y revisión de sentidos que permitan tensionar el conocimiento instituido, abriendo la posibilidad a nuevos conocimientos que aporten a una praxis social transformadora.En el año 2014 el territorio en donde se trabaja es el área de influencia del Centro de Salud San Isidro de la ciudad de Gualeguaychú. Se articuló con la Secretaria de Salud del Municipio la necesidad y viabilidad de trabajar con este efector.El plan de trabajo contempla el desarrollo de un Diagnóstico Sociocultural Participativo, en el cual se realiza el relevamiento y análisis de información empírica y la devolución de la información sistematizada a todos los participantes, con el fin de que se concreten procesos colectivos de objetivación de aspectos de su realidad, construyan saberes en torno a ellos, identifiquen problemáticas y definan líneas de acción que permitan mejorar alguna de las situaciones definidas por ellos como necesarias de ser modificadas.Partimos de la intencionalidad de generar procesos de reflexión colectiva con la población destinataria, en torno a representaciones y prácticas alimentarias, necesidades y demandas, objetivación de una problemática de su vida cotidiana que pudiera servir de punto de partida para pensar alternativas para alguna situación que amerite ser modificada. Cada espacio colectivo contempla instancias de evaluación de los mismos a fin de recoger las opiniones de los destinatarios, y este proceso es de suma importancia para diseñar las actividades posteriores del proyecto de extensión.Con los profesionales del Centro de salud involucrado se busca que profundicen sus saberes sobre la población a la que atiendan y, desde el análisis de la información sistematizada, puedan problematizar sus prácticas comunitarias y elaborar colectivamente, propuestas de acción.En el devenir del desarrollo del proyecto, la formación de los\/as estudiantes universitarios se orienta a facilitar la apropiación de conceptos y herramientas metodológicas para el diagnóstico sociocultural participativo y la intervención pedagógica y comunicacional en ámbitos comunitarios, a través de la articulación teoría y empiria. Se propicia el crecimiento de sus capacidades para: la problematización y el análisis de la realidad social desde la vida cotidiana; las prácticas sanitarias, educativas y comunicacionales; la aplicación de técnicas de relevamiento y análisis de información empírica; el diseño de material comunicacional educativo; la implementación de estrategias pedagógicas para la planificación y coordinación de espacios educativos con jóvenes y adultos en ámbitos comunitarios e institucionales. Se trabaja alternado momentos de formación en el aula universitaria y en la interacción con la realidad comunitaria.","palabras_clave":"Extensión universitaria|Estrategias de curricularización de la extensión| Enfoques socioeducativos de la extensión|Construcción de ciudadanía"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19561,"idioma_id":4,"titulo":"An optimization model for evaluating the economic impact of availability and maintenance notions during the synthesis and design of a power plant","resumen":"In this paper, we introduce an optimization strategy in order to comprehensively quantify the impact ofavailability and maintenance notions during the early stages of synthesis and design of a new natural gascombined cycle power plant. A detailed state-space approach is thoroughly discussed, where influenceof maintenance funds on each component?s repair rate is directly assessed.In this context, analysis of the reliability characteristics of the system is centered at two designer-adopted parameters, which largely influence the obtained results: the number of components whichmay fail independently at the same time, and the number of simultaneous failure\/repair events.Then, optimal solutions are evaluated as the availability-related parameters and the amount ofresources assigned for maintenance actions are varied across a wide range of feasible values, whichenable obtaining more accurate and detailed estimations of the expected economic performance for theproject when compared with traditional economic evaluation approaches.","palabras_clave":"NGCC power plant|Optimal design|Availability|Maintenance|Economic optimization|State-space approach"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19562,"idioma_id":4,"titulo":"Mesoporous Hybrid Thin Film Membranes with PMETAC@Silica Architectures: Controlling Ionic Gating Through the Tuning of Polyelectrolyte Density","resumen":"Manipulating molecular transport through mesoporous hybrid films is a   fascinating approach toward mimicking transport in nature. To understand   the details in controlled transport, it is necessary to gradually   adjust the charge density that in turn results in a precise adjustment   of permselectivity. We have created hybrid architectures through the   controlled polymerization of a strong polyelectrolyte:   (2-methacryloyloxy)ethyltrimethylammounium (PMETAC) in a mesoporous thin   silica film. PMETAC contents from 5 to 100% filling can be obtained by   choosing a temperature or light-induced polymerization route and by   varying polymerization times, as proven by ellipsoporosimetry and   infrared spectroscopy. Using cyclic voltammetry, we demonstrate that a   gradual variation of ionic permselectivity from a silanol-regulated to a   PMETAC-regulated permselectivity can be obtained by tuning the PMETAC   mesopore filling. The resulting behavior ranges from ion exclusion to   preconcentration. The experimental observations are correlated with   theoretical calculations that provide quantitative insights into the   organization of the ions and polymers within the pore. Our findings shed   light into the understanding of the interplay between charge density   and space on molecular transport, leading toward the rational design of   selectively transporting synthetic membranes.","palabras_clave":"mesoporous materials|polyelectrolyte|molecular theory|ion transport"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19563,"idioma_id":5,"titulo":"Zeranol y metabolitos urinarios de zearalenona en bovinos para carne","resumen":"Elnoreste argentino es, por sus características geográficas y ambientales, unaregión con fuerte poten-cial para la actividad ganadera. Los rodeos vacunos deesta zona tienen como base alimenticia pastizales y pasturas mejoradas, las quesuelen suplementarse con granos, fuentes proteicas y reservas en forma derollos o silaje. Estos alimentos son sustratos ricos para que especies dehongos produzcan micotoxinas como zearalenona (ZEA). El consumo de ZEA por losanimales hace que se excreten diferentes metabolitos en orina entre los que seencuentra el zeranol. Por su parte, la presencia de zeranol en orina esutilizada como indicador del uso indebido de promotores de crecimiento que sehallan prohibidos en el país. El objetivo de este trabajo fue analizar losmetabolitos relacionados con la ZEA excretados en la orina de novillos segúnlos siguientes tratamientos: alimentación con un concentrado de ZEA, exposicióna la aplicación de zeranol inyectable y acción simultánea de alimentación conun concentrado de ZEA más exposición a la aplicación de zeranol inyectable. Sepresentan los perfiles de metabolitos excretados en orina y su evolución en eltiempo.","palabras_clave":"Fusarium|Micotoxinas|Estrogenos|Zeranol|Zearalenona"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19564,"idioma_id":4,"titulo":"Morphometric variation in chromosomally polymorphic grasshoppers (Orthoptera: Acrididae) from South America:  Bergmann and converse Bergmann patterns","resumen":"Leptysma argentina Bruner, Trimerotropis pallidennis (Burmeister), and Cornops aquaticum Bruner are South-American grasshoppers (Orthoptera:Acrididae) whose chromosome polymorphisms were intensively studied. Leptysma argentina lives in central-east Argentina andin Uruguay and was polymorphic for a centric fusion whose presence is significantly correlated with a larger body size; this parameter wasshown to be associated with sexual selection and longevity selection; this species exhibited a marked latitudinal Bergmann pattern. In contrast,Trimerotropis pallidipennis followed a converse altitudinal Bergmann cline; males from higher altitudes were significantly smaller. Thisspecies supported an extended polymorphism for several inversions, which are correlated intrapopulationally with larger body size. Finally,C. aquaticum showed an evident example of Bergmann?s rule for tegmen length; this species was polymorphic for 3 centric fusions, whosefrequency increased southward, as in L. argentina. One of the fusions was associated with increased body size. We noticed that in all casesthe rearrangement that was related to body size increased in the direction in which this variable was adaptive, thus suggesting a possibleinvolvement of chromosome polymorphism in body size selection.","palabras_clave":"Leptysma argentina|Trimerotropis pallidipennis|Cornops aquaticum;|chromosome polymorphisms|Bergmann rule"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19565,"idioma_id":4,"titulo":"Phenotypic variation and sexual size dimorphism in Dichroplus elongatus (Orthoptera: Acrididae).","resumen":"Patterns of body size evolution are of particular interest because body size can affect virtually all the physiological and life history traits of an organism. Sexual size dimorphism (SSD), a difference in body size between males and females, is a widespread phenomenon in insects. Much of the variationin SSD is genetically based and likely due to differential selection acting on males and females. The importance of environmental variables and evolutionary processes affecting phenotypeic variation in both sexes may be useful to gain insights into insect ecology and evolution. Dichroplus elongatus Giglio-Tos isa South American grasshopper widely distributed throughout Argentina, Uruguay, most of Chile, and southern Brazil. In this study, we analyzed 122 adult females of D. elongatus collected in eight natural populations from central-east Argentina. Females show large body size variation among the analyzed 20 populations and this variation exhibits a strong relationship with fecundity. Our results have shown that larger females were more fecund than smaller ones. We found that ovariole number varied along a latitudinal gradient, with higher ovariole numbers in populations from warmer locations. A considerable female-biased SSD was detected. SSD for three analyzed morphometric traits scaled isometrically. However, SSD for thorax length displayed a considerable variation across the studied area, indicating a AQ225 larger relative increase in female size than in male size in warmer environmental conditions.","palabras_clave":"morphometric trait|fecundity|Orthoptera"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19566,"idioma_id":4,"titulo":"'Arsenic removal from water employing a combined system: photooxidation and adsorption'","resumen":"          A combined system employing photochemical oxidation (UV\/H2O2)  and adsorption for arsenic removal from water was designed and evaluated. In  this work, a bench scale photochemical annular reactor was developed being  connected alternately to a pair of adsorption columns filled with titanium  dioxide (TiO2) and granular ferric hydroxide (GFH). The experiences  were performed by varying the relation of As concentration (As (III)\/As (V) weight  ratio) at constant hydrogen peroxide concentration and incident radiation. Experimental  oxidation results were compared with theoretical predictions using an intrinsic  kinetic model previously obtained. In addition, the  effectiveness of the process was evaluated using a groundwater sample. The  mathematical model of the entire system was developed. It could be used as an  effective tool for design and prediction of the behaviour of these types of systems.  The combined technology results efficient and promising for arsenic removal to  small and medium scale.   ","palabras_clave":"ADSORPTION |ARSENIC|COMBINED TECHNOLOGY|GRANULAR FERRIC HYDROXIDE|TITANIUM DIOXIDE|UV\/H2O2 PROCESS|WATER TREATMENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19567,"idioma_id":5,"titulo":"Ciencias Sociales: una mirada desde el Consejo de Decanos de Ciencias Sociales y Humanas de Universidades Nacionales (CODESOC)","resumen":"Las Jornadas de Investigación, Docencia, Extensión y Ejercicio Profesional que llevan más de una década se han ido instalando en el colectivo profesional como un espacio muy nutricio a la hora de comprender con sentido crítico la vida social, el campo de las ciencias sociales y en él al Trabajo Social.Esta presentación por tanto oscilará entre el trabajo en que varios años transité como lo es el área d educación, y donde actualmente transito en el CODESOC y en el contexto político-institucional en el que ese tránsito se fue dando. Estos espacios muy vinculados a la gestión institucional nos zambullen en temas tales como la inversión que se hace o no desde el Estado en educación, la administración de recursos y en la necesaria reflexión acerca de cuál es el sentido político que la educación adquiere en nuestras propias unidades académicas nunca ajenas al proyecto de país que las contiene.Así como es necesario ubicar el sentido político que adquiere la educación en un país, no es posible comprender el sistema educativo hacerle preguntas también al modelo de desarrollo en el que ese sistema educativo es analizado.","palabras_clave":"CIENCIAS SOCIALES|EDUCACIÓN|ESTADO|TRABAJO SOCIAL|SOCIEDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19568,"idioma_id":4,"titulo":"A Mycobacterium tuberculosis dormancy antigen differentiates latently infected Bacillus Calmette-Guerin vaccinated individuals","resumen":"IFN-&#947; release assays (IGRAs) are better indicators ofMycobacteriumtuberculosis infection than the tuberculin skin test (TST) in Bacillus Calmette?Guérin (BCG)-vaccinated populations. However, IGRAs do not discriminate active and latent infections (LTBI) and no gold standard for LTBI diagnosis is available. Thus, since improved tests to diagnose M. tuberculosis infection are required, we assessed the efficacy of several M. tuberculosis latency antigens. BCG-vaccinated healthy donors (HD) and tuberculosis (TB) patients were recruited. QuantiFERON-TB Gold In-Tube, TST and clinical data were used to differentiate LTBI. IFN-&#947; production against CFP-10, ESAT-6, Rv2624c, Rv2626c and Rv2628 antigens was tested in peripheral blood mononuclear cells. LTBI subjects secreted significantly higher IFN-&#947; levels against Rv2626c than HD. Additionally, Rv2626c peptide pools to which only LTBI responded were identified, and their cumulative IFN-&#947; response improved LTBI discrimination. Interestingly,whole blood stimulation with Rv2626c allowed the discrimination between active and latent infections, since TB patients did not secrete IFN-&#947; against Rv2626c, in contrast to CFP-10+ESAT-6 stimulation that induced IFN-&#947; response from both LTBI and TB patients. ROC analysis confirmed that Rv2626c discriminated LTBI from HD and TB patients. Therefore, since only LTBI recognizes specific epitopes fromRv2626c, this antigen could improve LTBI diagnosis, even in BCG-vaccinated people.","palabras_clave":"Latent tuberculosis |Active tuberculosis|Diagnosis| IFN-gamma|Antigens"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19569,"idioma_id":4,"titulo":"A new mononuclear manganese(III) complex of an unsymmetrical hexadentate N3O3 ligand exhibiting superoxide dismutase and catalase-like activity: synthesis, characterization, properties and kinetics studies","resumen":"A mononuclear MnIII complex MnL·4H2O (H3L = 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N&#8242;-(2-hydroxybenzyl),N&#8242;-(4- methylbenzyl)amino]propan-2-ol) has been prepared and characterized. This complex catalyzes the dismutation of superoxide efficiently, with catalytic rate constant kcat=1.7 × 106M&#8722;1 s&#8722;1 and IC50 1.26 &#956;M, obtained through the nitro blue tetrazoliumphotoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. MnL is also able to disproportionate more than 300 equivalents of H2O2 in CH3CN, with initial rate of H2O2 decomposition given by ri=kcat [MnL]2 [H2O2]and kcat = 1.32 (2) mM&#8722;2 min&#8722;1. The accessibility of the MnIV state (Ep = 0.53 V vs. saturated calomel electrode), suggests MnL employs a high-valent catalytic cycle to decompose O2?&#8722; and H2O2.","palabras_clave":"Mn COMPLEX|SOD\/CAT ACTIVITY|KINETICS|MN-BASED ROS SCAVENGER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19570,"idioma_id":4,"titulo":"DEVELOPMENT AND CHARACTERIZATION OF DERMATAN SULFATE\/ CHITOSAN POLYELECTROLYTE COMPLEX PARTICLES WITH POTENTIAL APPLICATION IN THE TREATMENT AND DIAGNOSIS OF VASCULAR DISEASE","resumen":"    Cardiovascular disease is the largest single  cause of morbid-mortality in the developed and developing world. However, there  is still no pharmaceutical treatment that directly targets the blood vessel  wall instead of just controlling the risk factors. Here, we produced  polyelectrolyte particles (PEPs) by a simple and reproducible polyelectrolyte  complexation method between low molecular mass dermatan sulfate (LMMDS) (a  polyanionic polysaccharide) and chitosan (CS) (a polycationic polysaccharide)  and evaluated their interaction with vascular endothelial cells. The  composition and the composition homogeneity of the PEPs were confirmed by  13C-CP-MAS spectroscopy and by electrophoresis in a 6% polyacrylamide gel,  respectively. In addition, the hydrodynamic radius of the particles was in the  729 ± 11 nm range, as determined by dynamic light scattering. PEPs were not  cytotoxic for a murine heart endothelium-derived H5V cell line. Moreover,  fluorescent confocal microscopy showed the specific binding of  fluorescently-labeled PEPs to the endothelial cells. Overall, these findings  confirmed the potential of this nanotechnology platform for the targeting of  different agents to the vessel wall in the prevention, diagnosis and therapy of  vascular disease.  ","palabras_clave":"DERMATAN SULFATE|CHITOSAN|POLYELECTROLYTE PARTICLES|CARDIOVASCULAR DISEASE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19571,"idioma_id":4,"titulo":"Teeth microstructure analysis and feeding biology of Ophioplocus januarii (Echinodermata: Ophiuroidea) from northern Patagonia, Argentina","resumen":"The brittle star Ophioplocus januarii occurs from Golfo Nuevo,  Argentina, to northern Brazil, both at soft and hard substrates. Based on  stomach contents and teeth microstructure analysis, together with field  observations, the feeding habit of this species is described. Stomach contents  of monthly collected individuals at northern Patagonia from April 2005 to April  2007 were examined. Ten specimens from each month were analyzed; of the 250  only 78 (31.2%) had stomach contents while the remainder were empty. Opposite  to speculated previously O. januarii  is a microphagous species, feeding on macroalgae fragments (60.0% of the  stomachs with content), foreign plant structures (28.0%), animal cuticle  structures (13.0%), and unidentifiable material (30.7%). Less frequent items  found were foraminiferans, ostracods, amphipod, juvenile bivalve, and other  crustaceans. Small portions of the unidentifiable material were observed at the  optic microscope and under scanning electronic microscope resulting in digested  material, diatoms and small crustacean appendices. Suspension feeding was the  feeding mechanism observed at field. Analysis of the microstructure of the teeth  stereom revealed an intermediate fenestrated arrangement between the completely  fenestrated (uniform) described for macrophagous species and the compound teeth  of microphagous ophiuroids. A new kind of intermediate arrangement in the  dental matrix in ophiuroids is proposed. Ophioplocus  januarii is an omnivorous species, feeding mainly on algae, complemented  opportunistically with other items.","palabras_clave":"brittle star|stereom|stomach contents|Ophiolepididae|tooth type"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19572,"idioma_id":4,"titulo":"The electrocardiogram of anaesthetized Southern Sea Lion (Otaria flavescens) females","resumen":"The goal of this study was to characterize for the first time the electrocardiogram(ECG) of the southern sea lion (SSL) Otaria flavescens.Animals, materials and methods: Thirteen wild SSL females were captured at Isla de Lobos (Uruguay) and anesthetized with isofluorane. ECG recording was performed on anaesthetized animals at ventral recumbence following standardized procedures.Results: The ECG recordings showed normal sinus rhythm. Amplitude and duration of P and T waves,QRS complex, PR interval (PRi), QT interval (QTi) and ST segment (STs) were determined for allanimals in all leads. QT corrected (QTc) was determined in lead II. P wave polarity was consistentamong animals (positive in LI, LII, LIII and AVF leads and negative in AVL and AVR leads for allanimals), but T wave polarity did not present any constant pattern among animals, being either positive, negative or biphasic in different leads and different animals. The PRi (0.15 ± 0.2 sec) was similar to the allometric prediction for most of mammalian species including humans. The STs were normal in 10 of the SSL but showed STs depression in 3 of the animals. Almost all animals had a negative electrical axis (-30 to -120°), with one exception that showed a positive electrical axis (120°). Mean eupneic heart rate (HR) was 104.61 ± 10.06 (range = 88-120) beats per minute (bpm).Conclusions: This study was the first ECG description for this species, and provides valuable information for cardiac monitoring during anaesthesia.","palabras_clave":"Electrocardiography;|Pinnipeds; |Isofluorane anaesthesia; |Dive physiology"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19573,"idioma_id":4,"titulo":"Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamus","resumen":"Melanocortins are neuropeptides with well recognized anti-inflammatory and anti-apoptotic effects in the brain. Of the five melanocortin receptors (MCR), MC4R is abundantly expressed in the brain and is the only MCR present in astrocytes. We have previously shown that MC4R activation by the &#945;-melanocyte stimulating hormone (&#945;-MSH) analog, NDP-MSH, increased brain-derived neurotrophic factor (BDNF) expression through the classic cAMP-Protein kinase A-cAMP responsive element binding protein pathway in rat astrocytes. Now, we examined the participation of the mitogen activated protein kinases pathway in MC4R signaling. Rat cultured astrocytes treated with NDP-MSH 1&#8201;µM for 1&#8201;h showed increased BDNF expression. Inhibition of extracellular signal-regulated kinase (ERK) and ribosomal p90 S6 kinase (RSK), an ERK substrate, but not of p38 or JNK, prevented the increase in BDNF expression induced by NDP-MSH. Activation of MC4R increased cFos expression, a target of both ERK and RSK. ERK activation by MC4R involves cAMP, phosphoinositide-3 kinase (PI3K) and the non receptor tyrosine kinase, Src. Both PI3K and Src inhibition abolished NDP-MSH-induced BDNF expression. Moreover, we found that intraperitoneal injection of &#945;-MSH induces BDNF and MC4R expression and activates ERK and cFos in male rat hypothalamus. Our results show for the first time that MC4R-induced BDNF expression in astrocytes involves ERK-RSK-cFos pathway which is dependent on PI3K and Src, and that melanocortins induce BDNF expression and ERK-cFos activation in rat hypothalamus.","palabras_clave":"MELANOCORTINS|ASTROCYTES|BDNF|HYPOTALAMUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19574,"idioma_id":5,"titulo":"El legado 'maldito' de Auguste Comte: la 'auto-fundación' reflexiva de la sociología","resumen":"El presente artículo propone recuperar un aspecto de la obra de Auguste Comte que consideramos no se le ha dado la suficiente relevancia. Partiendo de los principios de su sociología del conocimiento, reconstruiremos una cuestión recurrente aún hoy en la teoría sociológica, y de la cual Comte se presenta como su primer exponente: la auto-justificación de la pertenencia de la sociología al ?canon? de los saberes científicos mediante argumentos propiamente sociológicos. Siguiendo algunas postulaciones de Comte en las primeras lecciones del Curso de Filosofía Positiva y en las dedicadas a la ?Física Social?, se pondrá énfasis en el carácter netamente sociológico, y por ende circular, de las razones a las que recurre para legitimar una ciencia de la sociedad. Esta circularidad, en el caso de Comte, se vuelve todavía más patente al sostener que es la sociología la que permitirá la consagración del estadio positivo a través de la formulación de una doctrina orgánica que reorganice la sociedad, sustentada, precisamente, en la auto-comprensión sociológica de lo social. Así, se conforma un ?legado maldito?, ya que estos argumentos reaparecen en cualquier teoría de peso como un problema persistente, pero también como una exigencia por fortalecer los argumentos legitimantes de la disciplina.","palabras_clave":"AGUSTE COMTE|TEORÍA SOCIOLÓGICA|EPISTEMOLOGÍA|CIRCULARIDAD"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19575,"idioma_id":4,"titulo":"Photoinactivation of tyrosinase sensitized by folic acid photoproducts","resumen":"Tyrosinase catalyzes in mammals the first and rate-limiting step in the biosynthesis of the melanin, the main pigment of the skin. Pterins, heterocyclic compounds able to photoinduce oxidation of biomolecules, accumulate in the skin of patients suffering from vitiligo, where there is a lack of melanin. Folic acid (PteGlu) is a conjugated pterin widespread in biological systems. Aqueous solutions of tyrosinase were exposed to UV-A irradiation (350 nm) in the presence of PteGlu and its photoproducts (6-formylpterin and 6-carboxypterin). The reactions were followed by UV?Vis spectrophotometry, enzyme activity measurement, fluorescence spectroscopy and HPLC. In this work, we present data that demonstrate unequivocally that solutions of tyrosinase exposed to UV-A irradiation in the presence of PteGlu, undergo enzyme inactivation. However, PteGlu itself causes a negligible effect on the activity of the enzyme. In contrast, PteGlu photoproducts are efficient photosensitizers. The tyrosinase inactivation involves two different pathways: (i) a photosensitization process and (ii) the oxidation of the enzyme by the hydrogen peroxide produced during the photooxidation of PteGlu and its photoproduct. The former pathway affects both the active site and the tryptophan residues, whereas the latter affects only the active site. The biologicalimplications of the results are discussed.","palabras_clave":"Tyrosinase |Folic acid |Folic acid photoproducts |Photosensitized processes |Reactive oxygen species|UV-A radiation |Vitiligo"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19576,"idioma_id":4,"titulo":"Unraveling the degradation mechanism of purine nucleotides photosensitized by pterins: the role of charge-transfer steps","resumen":"Photosensitizedreactions contribute to the generation of skin cancer and are used in manyapplications. The photosensitizers may act through different mechanisms. It iscurrently accepted that if the photosensitizer generates singlet molecularoxygen (1O2) upon irradiation, the target molecule isable to be oxidized by this ROS and the reaction needs dissolved O2to take place, the reaction is named a 1O2-mediatedoxidation (type II mechanism). However, this assumption is not always precise. Asan example of this type of case, we present here a study on the degradation of2´-deoxyguanosine 5´-monophosphate (dGMP) photosensitized by pterin. Wepropose a general mechanism to explain why the degradation of biological targets, such asnucleotides, photosensitized by pterins, naturally occurring 1O2photosensitizers, takes place through an electron-transfer initiated process(type I mechanism), being almost negligible the contribution of the 1O2-mediatedoxidation.","palabras_clave":"pterin|photosensitization|electron transfer|guanine radical|Type I\/Type II|dGMP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19577,"idioma_id":5,"titulo":"La guerra en los comienzos del antiguo Egipto: reflexiones a partir de la obra de Pierre Clastres","resumen":"En el marco de los estudios antropológicos sobre la guerra, la obra de Pierre Clastres es particularmente significativa. Sus enunciados sobre el modo en que opera la guerra en las sociedades no estatales del registro etnográfico permiten reflexionar a la vez sobre cómo dicha práctica contribuye al sostenimiento del statu quo autónomo e indiviso de la comunidad no estatal, y cómo la misma práctica puede en determinadas circunstancias contribuir a instancias radicales de transformación social, como serían la emergencia de liderazgos militares y la constitución de nuevos tipos de lazo social asociables a lo estatal.  La utilidad de recurrir a este tipo de enunciados surgidos de los estudios antropológicos para el abordaje de situaciones históricas antiguas, cuyos testimonios provienen mayormente del registro arqueológico, ha sido explicitada por no pocos investigadores. Partiendo de esta premisa, consideramos que el valle del Nilo de los períodos Paleolítico tardío al Dinástico Temprano (c. 20.000-2700 a.C.) ofrece un contexto privilegiado para pensar el problema de la guerra desde una lectura a la vez teórica e histórica, en la medida en que permite evaluar la incidencia de la guerra tanto en el marco de las comunidades no estatales como en su relación con la emergencia y consolidación de lo estatal en Egipto.","palabras_clave":"Guerra|Egipto|Antiguo|Clastres"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19578,"idioma_id":4,"titulo":"Is Forest Transition taking place? Evidence for the Semiarid Chaco in Argentina","resumen":"The expression Forest Transition (FT) and Ecological Transition (ET) were coined to describe the recovery path of forested areas (or more general natural vegetation) after heavy conversion into croplands. FT\/ET would be driven by two main socio-economic controls: a) agricultural intensification in the most productive areas and the simultaneous reduction of cropped area in the less suitable areas (land-sparing); and b) rural population migration from rural to urban areas. In the argentine portion of the Semiarid Chaco a rapid and extensive clearing for industrial agriculture and cattle ranching based on sown pastures is taking place. In this article we evaluated the occurrence, magnitude and localization of FT\/ET in the argentine portion of the Semiarid Chaco during the 1977?2007 period using an approach based on remotely sensed data. From land cover maps we derived three diagnosis variables of FT\/ET: (1) the area of natural vegetation at the end of the study period; (2) the rate of annual clearance (natural vegetation loss) for the whole period; and (3) the temporal change of the area of natural vegetation in the last portion of the study period. The diagnosis variables were combined to derive 12 classes (landscape types). We observed a systematic loss of the surface occupied by natural vegetation. Industrial agriculture grew in aggregated patches generating a homogenization of the landscape. In only a 4.8% of the study area we observed a pattern of change compatible with a FT\/ET. In contrast, in a 34% of the study region (9.57 million ha) a clear negative trend in the cover of natural vegetation was observed during 1977?2007 period. The area that had a negative trend in the cover of natural vegetation was 7 times greater than the portion of the region experiencing positive trends. Such number indicates an imbalance in the landscape dynamics that would further reduce areas covered by natural vegetation.","palabras_clave":"Forest transition|Land sparing|Deforestation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19579,"idioma_id":4,"titulo":"Triggered seismicity in the Andean arc region via static stress variations by the Mw=8.8, February 27, 2010, Maule earthquake","resumen":"In a narrow longitudinal Andean arc area, between 35°S and 36°S, crustal seismicity increased by more than nine times in the three-month period after the great Mw 8.8 Maule earthquake when compared to a similar period before the event. Here we explore how changes in Coulomb conditions associated with the mega-thrust earthquake triggered subsequent upper-plate events in the region.The localized seismicity defines an area of ~80 km long and ~18 km wide and NNW to NNE trend. Md magnitudes varied from 0.7 to 3.1 except for two earthquakes with Mw of 3.9 and 4.5, localized in the northern end of the area. We calculated the focal mechanisms for these two events as normal\/strike-slip and strike-slip respectively.During 2011, a 13 temporary station network was installed in the trasarc region in Malargüe, Argentina. 60 earthquakes were localized in the study region during an 8 month period. Static stress change calculations were performed using Coulomb criterion, assuming major previously proposed structures as receiver faults. We used previously published earthquake source parameters and slip distribution for the Maule quake. The largest contribution to total static stress, up to 5 bars, comes from the normal component, suggesting that the unclamping was the main process responsible for seismicity activation. Our results are totally consistent with co-seismic dilatational deformation inferred from GPS observations in the region and subsidence in nearby volcanoes caused by magma migration.Three different Quaternary tectonic settings ?extensional, strike-slip and compressional- have been proposed for the arc region at these latitudes. We found that the strike-slip regime is the most favorable, and only due to the unclamping produced by the Maule quake could the regime have temporarily changed to a normal\/strike-slip regime. The activation of Quaternary NNE to N-trending dextral strike-slip faults with dextral transtensional movement is inferred to be caused by the unclamping phenomenon.","palabras_clave":"Triggered seismicity|static stress variation|Andean arc region"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19580,"idioma_id":4,"titulo":"Isolation of a gene encoding a novel atypical LEA protein from the halophyte Prosopis strombulifera with a sodium salt-specific expression","resumen":"Salinity is one of the major abiotic stresses thatadversely affect the crop productivity and growth of thewhole plant. The halophytic Prosopis strombulifera(Fabaceae) shrub is a useful plant model to study themolecular and physiological mechanisms involved in salinitytolerance. In this work, the isolation and characterizationof the mRNA for a new atypical LEA protein(PsLEA3) is reported. PsLEA3 has alanine as the mostabundant amino acid followed by serine. This characteristicis different from typical LEA proteins which have highglycine content. PsLEA3 shows a negative average of hydropathyand remains localized in the chloroplast. Thephylogenetic relationship between related LEA proteinsand PsLEA3 showed that this protein belongs to the samegroup as a LEA protein of Arabidopsis. Northern analysisrevealed a differential expression of this atypical LEAmRNA in P. strombulifera plants under NaCl and Na2SO4treatments. Over-expression in roots of Na2SO4-treatedplants from Wo -1.9 MPa was associated with abscisicacid (ABA) and its conjugate (ABA-glucose ester) accumulationas well as with the root length of these plants,showing an inhibition and toxicity induced by sulphateanion present in the medium.","palabras_clave":"HALOPHYTE|LEA PROTEINS|NaCl|SO4Na2"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19581,"idioma_id":4,"titulo":"Evidence for homologous recombination in Chikungunya Virus","resumen":"Chikungunya Virus (CHIKV), a mosquito-transmitted alphavirus, causes acute fever and joint pain in humans. Recently, endemic CHIKV infection outbreaks have jeopardized public health in wider geographical regions. Here, we analyze the phylogenetic associations of CHIKV and explore the potential recombination events on 152 genomic isolates deposited in GenBank database. The CHIKV genotypes [West African, Asian, East\/Central\/South African (ECSA)], and a clear division of ECSA clade into three sub-groups (I?II?III), were defined by Bayesian analysis; similar results were obtained using E1 gene sequences. A nucleotide identity-based approach is provided to facilitate CHIKV classification within ECSA clade. Using seven methods to detect recombination, we found a statistically significant event (p-values range: 1.14 × 10&#8722;7?4.45 × 10&#8722;24) located within the nsP3 coding region. This finding was further confirmed by phylogenetic networks (PHI Test, p = 0.004) and phylogenetic tree incongruence analysis. The recombinant strain, KJ679578\/India\/2011 (ECSA III), derives from viruses of ECSA III and ECSA I. Our study demonstrates that recombination is an additional mechanism of genetic diversity in CHIKV that might assist in the cross-species transmission process.","palabras_clave":"CHIKUNGUNYA|PHYLOGENY|RECOMBINATION|EVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19582,"idioma_id":4,"titulo":"Abscisic acid enhances the immune response in Apis mellifera and contributes to the colony fitness","resumen":"The primary food of adult honey bees (Apis mellifera ) is honey prepared by bees from nectar, provided by plants in order to stimulate the bee?s pollination service. Nectar consists of carbohydrates, amino acids and water, as well as other minor compounds whose proportion varies among plant species and whose biological implications in the honey bee physiology require intense research. Several environmental stressors are causing the decline of bee colonies, and thereby, we tried to connect the nutritional quality of bee?s diet with the strength of the bee?s immune system. The phytohormone abscisic acid (ABA) is present in nectar, honey and adult honey bees. It has been demonstrated that ABA stimulates innate immune defences in animal cells. However, the influence of ABA on A. mellifera ?s health and fitness is unknown. Here, we show that honey bees fed with an ABA supplement in field experiments resulted in (i) the appearance of ABA in larvae and adult bees, (ii) enhanced haemocyte response to non-self recognition, (iii) improved wound healing and granulocyte and plasmatocyte activation and (iv) maximum adult bee population after the winter and increased pesticide tolerance. The results indicate that the naturally occurring compound ABA has a positive influence in honey bee immunity. ABA emerges as a potent booster of immune defence in A. mellifera and may be useful in addressing the colony losses threatening apiculture and pollination service worldwide.","palabras_clave":"Apis mellifera|abscisic acid|immune aptitude"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19583,"idioma_id":4,"titulo":"Adsorption of Bentazone from Aqueous Solutions Using Silica Particles","resumen":"Among various water purification and recycling  technologies, adsorption is a fast, inexpensive and universal  method. The development of low-cost adsorbents has led to the  rapid growth of research interests in this field. We have studied  the kinetics and thermodynamics of the adsorption of bentazone  on silica as a function of agitation time, adsorbent dose and  temperature in a batch process. We tried to find the best fitting  between experimental data and several theoretical models  (Langmuir, Freundlich, Brunauer-Emmett-Teller (BET) and  Temkin). As a result, the adsorption isotherms follow a BET  model. The adsorption kinetics was analyzed by using pseudo  first order and pseudo second order models. Thermodynamic  parameters of adsorption process (&#8710;G, &#8710;S and &#8710;H) were  computed. The effect of contact time on the removal efficiency of  studied substances was investigated. The highest removal  efficiency of bentazone was achieved by the adsorption on silica  particles. The adsorbent investigated exhibited potential  applications in water decontamination and treatment of  industrial and agricultural waste waters.","palabras_clave":"ADSORPTION|REMEDIATION|BENTAZONE|SILICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19584,"idioma_id":4,"titulo":"Ecophysiological basis of wood formation in ponderosa pine: linking water flux patterns with wood microdensity variables","resumen":"Climate and stands management have an effect on the process of wood formation via resource availability. To improve knowledge of wood quantity and physical structure, increment cores of ponderosa pine were taken in high- and low-density stands growing in Patagonia, Argentina. Microdensity profiles were performed on trees for which sapflow density (Qs) data were available over two consecutive years (2004 and 2005, dry and wet years, respectively). Conventional and non-conventional microdensity variables were analyzed in the segment of the microdensity profile where Qs was measured. Trees in the low-density stand showed a greater capacity for water transport than trees in the high-density stand, even if no constraints in the soil water availability were confirmed, as was the case for the wet year. Minimum and earlywood density were significantly higher in the high-density stand in several analyzed years. These differences were not reflected in mean density of the whole radial profile. The structural changes in physical wood properties in relation to silvicultural treatments appear to affect plant water status, even in the wet growing season: greater wood density in the first part of the tree-ring may contribute to the observed Qs decrease found in the high-density stand. This fact may lead trees to lack the coordinated mechanisms of response to drought observed in more xeric sites. The increase of wood density in the first part of the tree-ring in ponderosa pine could be not conducive to acclimation, exposing trees to an increasing ??dilemma?? facing drought.","palabras_clave":"WOOD DENSITY|SAPFLOW DENSITY|SILVICULTURE|DROUGHT|PATAGONIA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19585,"idioma_id":5,"titulo":"Singularidades de un escritor transatlántico: Entrevista a Vicente Luis Mora","resumen":"Entrevista digital para la Revista Celehis, de la Universidad Nacional de Mar del Plata (UNMdP, Argentina), con motivo de la visita de Vicente Luis Mora a nuestra Facultad para impartir una conferencia titulada 'La red como espacio literario transatlántico y global en lengua castellana: entre España y Argentina', en el Centro de Letras Hispanoamericanas el 26 de mayo de 2014. Realizada por la Dra. Laura Scarano, Directora del área de Literatura Española del Celehis y la Dra. Sabrina Riva, integrante del Grupo Semiótica del Discurso de la UNMdP. En la misma, el escritor andaluz reflexiona acerca de la nueva literatura española, el uso de las nuevas tecnologías en conexión con la literatura, la efectividad de algunas prácticas críticas y\/o escriturarias innovadoras que ha implementado -filmaciones, blog, el hoax de Quimera, el diario online de Alba Cromm, etc.-, el regreso a la elaboración de textos distópicos, el concepto de 'hispanismo transatlántico' de Julio Ortega, entre otras ideas, y, por supuesto, sobre su propia obra.","palabras_clave":"ENTREVISTA|VICENTE LUIS MORA|PANGEA|POSTPOESIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19586,"idioma_id":4,"titulo":"Are there any trade-offs between forage provision and the ecosystem service of C and N storage in arid rangelands?","resumen":"Changes in land use often increase the provisioning ecosystem services at the cost of decreasing the regulating services. Thus, the appropriation of primary production to optimize the supply of forage for livestock production may undermine C and N storage, essential to maintain the integrity of ecological systems and the biosphere. The aim of this work was to study this trade-off by estimating the effect of grazing intensity on two provisioning and regulating ecosystem services (forage supply and C and N storage respectively) in a 300 km2 Patagonian steppe. In areas with different historical sheep grazing regime (intensive, moderate and ungrazed), we estimated forage supply through the aboveground biomass of preferentially consumed species as well as total C and N storage in plants, through forage and non-forage aboveground biomass, litter and root biomass in the top 20 cm of soil. We found that forage supply and C and N storage were highest in moderately grazed areas and were positively correlated, indicating the absence of trade-offs between them. Grazing exclusion had no effect on total plant C and N, but decreased these stocks in green grass biomass in relation to moderate grazing. Intensive grazing decreased both provisioning and regulating services, markedly diminishing grass C and N stocks and grass forage compared to other conditions. Conversely, shrubs and roots were not influenced by grazing regime. This study provides evidence that in arid rangelands, an adequate grazing management could be a key control to complementarily maximize both provisioning and regulating ecosystem services.","palabras_clave":"Patoreo Ovino|Ingeniero ecosistemico|Forrajeo optimo|desertificacion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19587,"idioma_id":4,"titulo":"Biological and physical factors affecting the colonization of vegetation-free patches in a SW Atlantic salt marsh","resumen":"In many Northern Hemisphere salt marshes, recovery of disturbance-generated bare areas usually occurs within a few years. However, in some southwestern Atlantic marshes, bare patches may remain unchanged for several years. Here we investigated biological and physical factors that might affect bare patch colonization in a Mar Chiquita coastal lagoon salt marsh (Argentina). We evaluated natural seedling emergence of the pioneer pickleweed plant Sarcocornia perennis, considering distance to mature plants and the herbivory\/bioturbation exerted by the crab Neohelice granulata (using exclosures). Almost no seedling emergence was observed in patches distant from mature plants, while higher emergence resulted in close patches. Crab exclusion did not affect seedling counts. Nevertheless, most of these seedlings did not survive high-temperature months. We analyzed if colonization was favored by increasing the availability of S. perennis seeds, and we found similar seedling emergence in patches both close and distant to mature plants. As in the previous experiment, most of them did not survive the high-temperature months, but some seedlings could establish within crab exclosures. Finally, we used a shade cloth to reduce solar radiation, but this did not increase seedling survival, which was only favored in crab exclosures. In summary, our results suggest that seed availability, followed by the presence of crabs (but not solar radiation), affect the rate of patch recovery. Additionally, our results show that life-history traits (seed ecology) of the colonizer can be a key and are a usually overlooked driver of salt marsh secondary succession.&nbsp;","palabras_clave":"Patch dynamics|Seedling emergence|Colonization|Sarcocornia perennis|Neohelice (Chasmagnathus) granulata|Seed dispersal|Bioturbation|Salt patches"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19588,"idioma_id":4,"titulo":"Evaluation of biological pretreatments to increase the efficiency of the saccharification process using Spartina argentinensis as a biomass resource","resumen":"Second generation bioethanol obtained from native perennial grasses offers a promising alternative for biofuel production, avoiding land use competition for crops production. Spartina argentinensis is a native perennial C4 grass with high photosynthetic rates, well adapted to halo-hydromorphic soils, though its forage quality (palatability and digestibility) for livestock is quite low due to its high lignin content. Hence, cattle raisers burn these grasslands frequently in order to stimulate the emergence of new leaves with higher digestibility for cattle feeding. Lignin is the main barrier to overcome in order to efficiently hydrolyze the cellulose for bioethanol production. In this work, we evaluate different pretreatments (phosphoric acid, ligninolytic enzymes and fungal supernatants) aimed to remove lignin and improving cellulose hydrolysis efficiency. Results show that pretreatment with Pycnoporus sanguineus supernatant improves fermentable carbohydrates availability, compared with a conventional chemical pretreatment, and that 56.84% of cellulose can be hydrolyzed using this pretreatment.","palabras_clave":"BIOMASS|SECOND GENERATION BIOETHANOL|PRETREATMENTS|LIGNOCELLULOSE|WHITE ROT FUNGI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19589,"idioma_id":4,"titulo":"Acidosis-induced downregulation of hepatocyte mitochondrial aquaporin-8 and ureagenesis from ammonia","resumen":"It has been proposed that during metabolic acidosis, the liver downregulates mitochondrial ammonia detoxification via ureagenesis, a bicarbonate-consuming process. Since we previously demonstrated that hepatocyte mitochondrial aquaporin-8 channels (mtAQP8) facilitate the uptake of ammonia and its metabolism into urea, we studied whether mtAQP8 is involved in the liver adaptive response to acidosis. Primary cultured rat hepatocytes were adapted to acidosis by exposing them to culture medium at pH 7.0 for 40 h. Control cells were exposed to pH 7.4. Hepatocytes exposed to acid medium showed a decrease in mtAQP8 protein expression (-30%, p&lt;0.05). Ureagenesis from ammonia was assessed by incubating the cells with 15N-labeled ammonia and measuring 15N-labeled urea synthesis by nuclear magnetic resonance. Reduced ureagenesis was found in acidified hepatocytes (-31%, p&lt;0.05). In vivo studies in rats subjected to 7-days acidosis also showed decreased protein expression of hepatic mtAQP8 (-50%, p&lt;0.05) and reduced liver urea content (-35%; p&lt;0.05).  In conclusion, our in vitro and in vivo data suggest that hepatic mtAQP8 expression is downregulated in acidosis, a mechanism that may contribute to decreased ureagenesis from ammonia in response to acidosis.","palabras_clave":"AQUAPORIN 8|HEPATOCYTE|MITOCHONDRIAL AMMONIA TRANSPORT|ACIDOSIS|UREAGENESIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19590,"idioma_id":4,"titulo":"Biochemical Capacitance of Geobacter Sulfurreducens biofilms","resumen":"An electrical model able to decouple the electron pathway from microbial cell machinery impedance terms is introduced. In this context, capacitance characteristics of the biofilm are clearly resolved. In other words, the model allows separating, according to the advantage of frequency and spectroscopic response approach, the different terms controlling the performance of the microbial biofilm respiratory process and thus the directly related electricity production process. The model can be accurately fitted to voltammetry measurements obtained under steady-state conditions and also to biofilm discharge amperometric measurements. The implications of biological aspects of the electrochemical or redox capacitance are discussed theoretically in the context of current knowledge with regard to structure and physiological activity of microbial Geobacter biofilms.","palabras_clave":"BIOFILMS|GEOBACTER|CAPACIDAD REDOX|IMPEDANCIA ELECTROQUÍMICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19591,"idioma_id":4,"titulo":"Histological analysis following arm tip amputation in Ophioplocus januarii (Echinodermata: Ophiuroidea)","resumen":"Arm tip regeneration after amputation in the brittle star Ophioplocus januarii was examined in order to observe the histological and morphological changes leading to arm regeneration. The process of regeneration is described and compared with other brittle stars species. The regenerative process of arm regeneration in O. januarii involves the closure of the wound, the repair of the tissue damage and posterior formation of a presumptive stalked blastema by undifferentiated cells, sclerocytes and presumptive blastemic cells. The sclerocytes are the more abundant cell type during the regeneration process. This evidence confirms the regenerative process described in other brittle stars species and suggests this process is a common feature among the Ophiuroidea.","palabras_clave":"BRITTLE STAR|ECHINODERM|HISTOLOGICAL ANALYSIS|REGENERATION|SCLEROCYTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19592,"idioma_id":4,"titulo":"Phytomonas: a non-pathogenic trypanosomatid model for functional expression of proteins","resumen":"Phytomonas are protozoan parasites from the Trypanosomatidae family which infect a wide variety of plants. Herein, Phytomonas Jma was tested as a model for functional expression of heterologous proteins. Green fluorescent protein expression was evaluated in Phytomonas and compared with Trypanosoma cruzi, the etiological agent of Chagas´ disease. Phytomonas was able to express GFP at levels similar to Trypanosoma cruzi although the transgenic selection time was higher.It was possible to establish an efficient transfection and selection protocol for protein expression.These results demonstrate that Phytomonas can be a good model for functional expression of proteins from other trypanosomatids, presenting the advantage of being completely safe for humans.","palabras_clave":"Phytomonas|protein expression|Trypanosoma cruzi|Trypanosomatids"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19593,"idioma_id":4,"titulo":"Modulation by geraniol of gene expression involved in lipid metabolism leading to a reduction of serum-cholesterol and triglyceride levels","resumen":"Abstract  Background  Geraniol (G) is a natural isoprenoid present in the essential oils of several aromatic plants, with various biochemical and pharmacologic properties. Nevertheless, the mechanisms of action of G on cellular metabolism are largely unknown.  Hypothesis\/Purpose  We propose that G could be a potential agent for the treatment of hyperlipidemia that could contribute to the prevention of cardiovascular disease. The aim of the present study was to advance our understanding of its mechanism of action on cholesterol and TG metabolism.  Study Design\/Methods  NIH mice received supplemented diets containing 25, 50, and 75 mmol G\/kg chow. After a 3-week treatment, serum total-cholesterol and triglyceride levels were measured by commercial kits and lipid biosynthesis determined by the [14C] acetate incorporated into fatty acids plus nonsaponifiable and total hepatic lipids of the mice. The activity of the mRNA encoding HMGCR?the rate-limiting step in cholesterol biosynthesis?along with the enzyme levels and catalysis were assessed by real-time RT-PCR, Western blotting, and HMG-CoA-conversion assays, respectively. In-silico analysis of several genes involved in lipid metabolism and regulated by G in cultured cells was also performed. Finally, the mRNA levels encoded by the genes for the low-density-lipoprotein receptor (LDLR), the sterol-regulatory-element-binding transcription factor (SREBF2), the very-low-density-lipoprotein receptor (VLDLR), and the acetyl-CoA carboxylase (ACACA) were determined by real-time RT-PCR.  Results  Plasma total-cholesterol and triglyceride levels plus hepatic fatty-acid, total-lipid, and nonsaponifiable-lipid biosynthesis were significantly reduced by feeding with G. Even though an up-regulation of the mRNA encoding HMGCR occurred in the G treated mouse livers, the protein levels and specific activity of the enzyme were both inhibited. G also enhanced the mRNAs encoding the LDL and VLDL receptors and reduced ACACA mRNA, without altering the transcription of the mRNA encoding the SREBF2.  Conclusions  The following mechanisms may have mediated the decrease in plasma lipids levels in mice: a down-regulation of hepatocyte-cholesterol synthesis occurred as a result of decreased HMGCR protein levels and catalytic activity; the levels of LDLR mRNA became elevated, thus suggesting an increase in the uptake of serum LDL, especially by the liver; and TG synthesis became reduced very likely because of a decrease in fatty-acid synthesis.","palabras_clave":"GERANIOL|HYPOLIPEMIA|LIPOGENESIS|HMGCR|ACACA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19594,"idioma_id":4,"titulo":"A checklist of marine larval trematodes (Digenea) in molluscs from Argentina, Southwestern Atlantic coast","resumen":"A checklist of cercariae parasitizing marine molluscs from Patagonian coast, Argentina, based onliterature sources and new records here presented. In total, cercariae of 31 species of marine digeneans, including 11 new records here presented, are known to infect 20 species of molluscs (14 in nine gastropods species; 17 in 11 bivalve species). These records include two speciesof Aporocotylidae, four Bucephalidae, one Fellodistomidae, five Gymnophallidae, one Hemiuroidea, four Lepocreadiidae, two Microphallidae, five Monorchiidae, oneNotocotylidae, one Philophthalmidae, two Renicolidae, one Schistosomatidae and two Zoogonidae. For each digenean species, their hosts, habitat type, localities, infectionsite, prevalence, life cycle advances, and access numbers in helminthological collections and GenBank, when available, are detailed. Regarding the life cycles, eight were completely elucidated and four were partially elucidated. Moreover, there are molecular data for 15 species.The data here presented constitutes an advance in the parasites biodiversity knowledge and their life cycles.","palabras_clave":"PARASITOS|TAXONOMIA|DISTRIBUCION GEOGRAFICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19595,"idioma_id":4,"titulo":"Echinoderms diversity in the Southwestern Atlantic","resumen":"Since  2009 the B\/O Puerto Deseado has been  performing benthic exploration cruises along the ArgentineSea and adjacent waters including Antarctica. The aim of this work was to enhance the  knowledge on the diversity of echinoderms based on samples taken on three  expeditions along the Argentinean coast (35º-55ºS) and near the Antarctic Peninsula. The first campaign, Mejillón II (M-II; 2009), was carried  out between 35º-39ºS and covered a depth range between 10 to 140 m. The second was part of  the Summer Antarctic Campaign 2011 (CAV-III; 2011) that took place  around the Antarctic Peninsula, South Shetland and South   Orkney Islands (depth range between 67 to 754 m). The last cruise was  the final stretch of the Summer Antarctic  Campaign 2011 (CAV-IV; 2011),  from 39º-55ºS and between 30-140   m depth. As result, 74 stations have been studied, of  which 68 were found at least one echinoderm specimen. From the total number of  stations, the occurrence percentages for each class were Asteroidea (68%),  Echinoidea (64%), Ophiuroidea (55%), Holothuroidea (51%) and Crinoidea (20%).  In the campaign M-II, echinoderms were presented in 94% of the sampled  stations, being Echinoidea the most frequent (74%). Regarding CAV-III campaign,  echinoderms were presented in all the stations sampled; Ophiuroidea was the  most representative class in number of stations (100%). The lowest occurrence  of echinoderms was found in CAV-IV campaign (82%), where Asteroidea was present  in the 73% of the samples, and crinoids were absent. As conclusion, all the  echinoderm classes were present in the Antarctic samples, and in 88% of the  stations of M-II and CAV-IV, for Argentine Sea. Future projects will be focus  on the study of the echinoderms species not yet described, as well as their  interaction with other invertebrates, relatively unknown, but with high  proportion in these benthic communities.","palabras_clave":"ECHINOCERMATA|BIODIVERSITY|B\/O PUERTO DESEADO|ARGENTINE SEA|ANTARCTICA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19596,"idioma_id":4,"titulo":"Dietary I(-) absorption: expression and regulation of the Na(+)\/I(-) symporter in the intestine","resumen":"Thyroid hormones are critical for the normal development, growth, and functional maturation of several tissues, including the central nervous system. Iodine is an essential constituent of the thyroid hormones, the only iodine-containing molecules in vertebrates. Dietary iodide (I(-)) absorption in the gastrointestinal tract is the first step in I(-) metabolism, as the diet is the only source of I(-) for land-dwelling vertebrates. The Na(+)\/I(-) symporter (NIS), an integral plasma membrane glycoprotein located in the brush border of enterocytes, constitutes a central component of the I(-) absorption system in the small intestine. In this chapter, we review the most recent research on structure\/function relations in NIS and the protein's I(-) transport mechanism and stoichiometry, with a special focus on the tissue distribution and hormonal regulation of NIS, as well as the role of NIS in mediating I(-) homeostasis. We further discuss recent findings concerning the autoregulatory effect of I(-) on I(-) metabolism in enterocytes: high intracellular I(-) concentrations in enterocytes decrease NIS-mediated uptake of I(-) through a complex array of posttranscriptional mechanisms, e.g., downregulation of NIS expression at the plasma membrane, increased NIS protein degradation, and reduction of NIS mRNA stability leading to decreased NIS mRNA levels. Since the molecular identification of NIS, great progress has been made not only in understanding the role of NIS in I(-) homeostasis but also in developing protocols for NIS-mediated imaging and treatment of various diseases.","palabras_clave":"DIETARY IODIDE|SODIUM\/IODIDE SYMPORTER|THYROID HORMONES|SMALL INTESTINE ABSORPTIVE ENTEROCYTES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19597,"idioma_id":4,"titulo":"ULTRASONIC-ASSISTED DISSOLUTION OF VEGETABLE OILS WITH TETRABUTYLAMMONIUM HYDROXIDE FOR MULTIELEMENTAL ANALYSIS BY INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY","resumen":"A novel, simple, and rapidmethod is presented for thedetermination of B, Cl, Ga, Ge,As, Br, Se, Sn, Sb, I, Te, Pb, and Biin vegetable oil samples by inductivelycoupled plasma mass spectrometry(ICP-MS) after samplesolubilization with tetrabutylammoniumhydroxide (TBAH) in anultrasonic bath. Sample introductionwas accomplished after dilutionin water with a high-performancemicroconcentric nebulizerand a cooled spray chamber.The sample was mixed withTBAH, kept in an ultrasonic bathwith heat for half an hour, andthen diluted with nitric acid toform an aqueous solution. Externalcalibration against aqueousstandard solutions, withoutTBAH, was used for quantificationof a number of elements.However, external calibrationwith TBAH allowed the determinationof all analytes with goodaccuracy. Comparison of theobtained results with microwave-assisted digestion was performedby linear regression.","palabras_clave":"Ultrasonic-assisted Dissolution|Tetrabutylammonium Hydroxide|Vegetable Oils|ICP-MS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19598,"idioma_id":5,"titulo":"Utilidad de una mezcla prebiótica para aumentar la absorción y biodisponibilidad de Ca durante el crecimiento normal y durante la recuperación de una malnutrición proteica: modelo experimental en ratas","resumen":"Resumen  La nutrición determina el crecimiento lineal y la acumulación de masa ósea, modulando el potencial genético. La ingesta adecuada de calcio (Ca) es crítica para alcanzar el máximo pico de masa ósea. Ante un bajo aporte de Ca, una estrategia sería aumentar su absorción y biodisponibilidad. Los galactooligosacáridos (GOS) y fructooligosacáridos (FOS) favorecen la absorción de Ca.  Objetivo: evaluar el efecto de una mezcla GOS\/FOS® 9:1 sobre absorción de Ca, fosforo (P) y magnesio (Mg) y retención ósea, durante crecimiento normal o recuperación nutricional. Se evaluaron pH luminal, peso del colédoco, recuento de lactobacilos y actividad enzimática para explicar los hallazgos del estudio.  Métodos: Crecimiento normal: Al destete y hasta 40 días, ratas macho recibieron: C5-40: AIN 93G (DNCa); C3-40: AIN 93G conteniendo 0.3% Ca (DHCa); P3: AIN 93G conteniendo 0.3% Ca + 5.3% GOS\/FOS®. Recuperación nutricional: Grupos desnutridos (D) recibieron una dieta hipoproteica durante la semana postdestete. Luego, hasta 50 días recibieron: DC50: DNCa; DP50: DNCa Ca + 5.3% GOS\/FOS®. Control C5-50: recibió DNCa del destete hasta los 50 días.   Semanalmente se evaluó consumo de alimentos, absorción de Ca, Mg y P (mg\/d y %) y desarrollo de lactobacilos. Al sacrificio se midió pH cecal, contenido mineral en fémur, biomecánica y densitometría (Lunar DXA).   Resultados: En ambos modelos experimentales el consumo de la mezcla prebiótica disminuyó el pH cecal y aumentó el desarrollo de lactobacilos (p<0.001), absorción de Ca, Mg y P (p<0.001), cantidad femoral de Ca y P (p<0.05), parámetros densitométricos (p<0.01) y biomecánicos (p<0.05).  Conclusión: La mezcla prebiótica utilizada favorece la absorción de mineral induciendo su mayor retención en hueso, lo que asegura una cantidad extra para favorecer la salud ósea","palabras_clave":"prebioticos|absorción de Ca, P y Mg|hueso|desnutridos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19599,"idioma_id":4,"titulo":"An auditory illusion of proximity of the source induced by sonic crystals","resumen":"In this work we report an illusion of proximity of a sound source created by a sonic crystal placed between the source and a listener. This effect seems, at first, paradoxical to naïve listeners since the sonic crystal is an obstacle formed by almost densely packed cylindrical scatterers. Even when the singular acoustical properties of these periodic composite materials have been studied extensively (including band gaps, deaf bands, negative refraction, and birrefringence), the possible perceptual effects remain unexplored. The illusion reported here is studied through acoustical measurements and a psychophysical experiment. The results of the acoustical measurements showed that, for a certain frequency range and region in space where the focusing phenomenon takes place, the sonic crystal induces substantial increases in binaural intensity, direct-to-reverberant energy ratio and interaural cross-correlation values, all cues involved in the auditory perception of distance. Consistently, the results of the psychophysical experiment revealed that the presence of the sonic crystal between the sound source and the listener produces a significant reduction of the perceived relative distance to the sound source.","palabras_clave":"Auditory Distance Perception|Sonic Crystals|Reverberation|Binaural correlation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19600,"idioma_id":4,"titulo":"State-Space Approach to Structural Representation of Perturbed Pitch Period Sequences in Voice Signals","resumen":"Objectives. The aim of this study is to propose a state space based approach to model perturbed pitch period sequences (PPSs), extracted from real sustained vowels, combining the principal features of disturbed real PPSs with structural analysis of stochastic time series and state space methods.Methods. The PPSs were obtained from a database composed of 53 healthy subjects. State space models were developed taking into account different structures and complexity levels. PPS features such as trend, cycle and irregular structures were considered. Model parameters were calculated using optimization procedures. For each PPS, state estimates were obtained combining the developed models and diffuse initialization with filtering and smoothing methods. Statistical tests were applied to objectively evaluate the performance of this method. Results. Statistical tests demonstrated that the proposed approach correctly represented more than the 75% of the database with a significance value of 0.05. In the analysis, structural estimates suitably characterized the dynamics of the PPSs. Trend estimates proved to properly represent slow long-term dynamics, while cycle estimates captured short-term, auto-regressive dependencies.Conclusions. The present study demonstrated that the proposed approach is suitable for representing and analyzing real perturbed PPSs, also allowing to extract further information related to the phonation process.","palabras_clave":"Perturbed pitch periods|Stochastic pitch model|Jitter|Structural time-series analysis|State-space models"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19601,"idioma_id":4,"titulo":"Characterization of repetitive DNA landscape in wheat homeologous group 4 chromosomes","resumen":"ABSTRACT  Background: The number and complexity of repetitive elements varies between species, being in general most represented in those with larger genomes. Combining the flow-sorted chromosome arms approach to genome analysis with second generation DNA sequencing technologies provides a unique opportunity to study the repetitive portion of each chromosome, enabling comparisons among them. Additionally, different sequencing approaches may produce different depth of insight to repeatome content and structure. In this work we analyze and characterize the repetitive sequences of Triticum aestivum cv. Chinese Spring homeologous group 4 chromosome arms, obtained through Roche 454 and Illumina sequencing technologies, hereinafter marked by subscripts 454 and I, respectively.  Repetitive sequences were identified with the RepeatMasker software using the interspersed repeat database mips-REdat_v9.0p. The input sequences consisted of our 4DS454 and 4DL454 scaffolds and 4ASI, 4ALI, 4BSI, 4BLI, 4DSI and 4DLI contigs, downloaded from the International Wheat Genome Sequencing Consortium (IWGSC). Results: Repetitive sequences content varied from 55% to 63% for all chromosome arm assemblies except for 4DLI, in which the repeat content was 38%. Transposable elements, small RNA, satellites, simple repeats and low complexity sequences were analyzed. SSR frequency was found one per 24 to 27 kb for all chromosome assemblies except 4DLI, where it was three times higher. Dinucleotides and trinucleotides were the most abundant SSR repeat units. (GA)n\/(TC)n was the most abundant SSR except for 4DLI where the most frequently identified SSR was (CCG\/CGG)n. Retrotransposons followed by DNA transposons were the most highly represented sequence repeats, mainly composed of CACTA\/En-Spm and Gypsy superfamilies, respectively. This whole chromosome sequence analysis allowed identification of three new LTR retrotransposon families belonging to the Copia superfamily, one belonging to the Gypsy superfamily and two TRIM retrotransposon families. Their physical distribution in wheat genome was analyzed by fluorescent in situ hybridization (FISH) and one of them, the Carmen retrotransposon, was found specific for centromeric regions of all wheat chromosomes.   Conclusion: The presented work is the first deep report of wheat repetitive sequences analyzed at the chromosome arm level, revealing the first insight into the repeatome of T. aestivum chromosomes of homeologous group 4.","palabras_clave":"TRITICUM AESTIVUM|CHROMOSOME 4D SURVEY|REPETITIVE ELEMENTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19602,"idioma_id":4,"titulo":"Personality and alcohol expectancies discriminate alcohol consumption patterns in female college students","resumen":"Aims: To characterize patterns of alcohol use in a sample of Argentinean female college students according to personality traits and alcohol expectancies. Methods: Data from 298 female college students (M age = 18.27 years; SD = 1.37 years) from the city of Cordoba, Argentina were analyzed   using multinomial regression. Results: Three drinking categories were identified, abstainers, moderate drinkers and regular drinkers with heavy episodic drinking, and these were differentiated by three personality traits (extraversion, disinhibition, experience seeking), and three alcohol expectancies dimensions (sociability, risk\/aggression and negative mood).  Regular drinkers with heavy episodic drinking and moderate drinkers had, compared to abstainers, higher scores in extroversion and alcohol expectancies for social facilitation, and lower scores in alcohol expectancies for risk and aggression. Regular drinkers with heavy episodic drinking exhibited, compared to moderate drinkers, higher scores in experience seeking, disinhibition, extroversion, alcohol expectancies for social facilitation, and negative mood alcohol expectancies; as well as lower scores in risk and aggression alcohol expectancies. Conclusions: College women in Argentina with problematic alcohol drinking can be distinguished from those drinking moderately by personality traits and expectations about the effects of alcohol.","palabras_clave":"ALCOHOL USE|COLLEGE WOMEN|PERSONALITY TRAITS|ALCOHOL EXPECTANCIES|LATENT CLASS ANALYSIS|MULTINOMIAL REGRESSION ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19604,"idioma_id":5,"titulo":"Valoración de las propiedades psicométricas del Cuestionario  de Motivos de Apuestas en jóvenes y adultos argentinos","resumen":"El presente trabajo tuvo como objetivo evaluar, en una muestra de apostadores jóvenes y adultos de la comunidad general, las propiedades psicométricas de estructura y consistencia interna del Cuestionario de Motivos de Apuestas en sus dos versiones: original (GMQ) y revisada (GMQ-F).  Específicamente, se efectuó un análisis factorial confirmatorio para evaluar el ajuste de ambos modelos. Luego se analizó la consistencia interna de las escalas y se analizó la utilidad de las escalas para predecir un mayor nivel de severidad en los juegos de apuestas. Participaron 341 jóvenes y adultos, con edades entre 18 y 60 años, que reportaron tomar realizar apuestas en los últimos seis meses.  Para evaluar el ajuste de los modelos propuestos se utilizó el método de estimación máxima verosimilitud (ML) con la corrección robusta de Satorra-Bentler. Los resultados indicaron que los modelos GMQ y GMQ-F presentan un ajuste razonable a los datos. Todas las escalas presentan adecuados valores de consistencia interna. Los motivos de mejora, afrontamiento y financieros se relacionan con una mayor severidad de problemas con las apuestas.  En general, los resultados indican que ambos modelos cuentan con adecuadas propiedades psicométricas, sin embargo, el GMQ-F se ofrece como una alternativa más completa para la medición de los motivos de apuestas en la comunidad general.","palabras_clave":"MOTIVOS APUESTAS|JOVENES|ADULTOS|PSICOMETRIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19605,"idioma_id":4,"titulo":"No defensive role of ants throughout a broad latitudinal and elevational range of a cactus","resumen":"Defensive mutualisms mediated by extrafloral nectaries are particularly variable; their net results may change with seasons, communities and environmental contexts. Particularly, an environmental factor that can promote changes in outcomes of ant-plant interactions is elevation in mountainous regions. We tested whether (1) the interaction between the cactus Opuntia sulphurea and ant visitors of extrafloral nectaries is a defensive mutualism; and (2) ant-plant interaction outcomes vary with elevation as a result of changes in herbivory rate and ant activity. To evaluate if the outcome of interactions was consistent at two extremes of the range distribution of O. sulphurea, we performed an ant-exclusion experiment with plants at two growth conditions (natural or potted) in two sites with contrasting elevation (1235?1787 m asl) in a temperate region (Villavicencio Nature Reserve, Mendoza, Argentina), and in a tropical region (Huajchilla, La Paz, Bolivia). Although herbivory rate and ant visitation frequency increased with elevation, herbivore damage, plant reproductive success, and cladode growth rate were similar between plants excluded and non-excluded from ants among sites, geographic regions and growth conditions. These results do not support the hypotheses that the interaction between O. sulphurea and ants is a defensive mutualism, and that elevation affects the net outcome of this ant-plant interaction.","palabras_clave":"ANT-PLANT MUTUALISM|COMMENSALISM|GEOGRAPHIC VARIATION|INSECT ABUNDANCE|TEMPERATE REGION|TROPICAL REGION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19606,"idioma_id":4,"titulo":"Molecular analyses detect natural coinfection of water buffaloes (Bubalus bubalis) with bovine viral diarrhea viruses (BVDV) in serologically negative animals","resumen":"Infection of water buffaloes (Bubalus bubalis) with bovine viral diarrhea viruses (BVDV) has been confirmed in several studies by serological and molecular techniques. In order to determine the presence of persistently infected animals and circulating species and subtypes of BVDV we conducted this study on a buffalo herd, whose habitat was shared with bovine cattle (Bossp.). Our serological results showed a high level of positivity for BVDV-1 and BVDV-2 within the buffalo herd. The molecular analyses of blood samples in serologically negative animals revealed the presence of viral nucleic acid, confirming the existence of persistent infection in the buffaloes. Cloning and sequencing of the 5´ UTR of some of these samples revealed the presence of naturally mix-infected buffaloes with at least two different subtypes (1a and 1b), and also with both BVDV species (BVDV-1 and BVDV-2).","palabras_clave":"BUFALO|BVDV|SUBTYPE|COINFECTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19607,"idioma_id":4,"titulo":"Morphology and dynamics of large subtidal dunes in Bahia Blanca estuary, Argentina","resumen":"The purpose of this paper is to carry out a detailed analysis of subtidal dune morphology and temporal variability and to estimate dune migration rate to improve knowledge of this topic, and so enhance the existing data on different  marine environments in theworld and especially in South America where this information is limited. Two swath bathymetry surveys were conducted across a dune field in the Bahia Blanca Estuary (Argentina). Morphometric parameters and migration rate according to the dune type, were analyzed. The field is composed of large dunes exhibiting two morphological configurations, which are differentiated into sinuous and barchan dunes.  The dunes studied are the largest of the estuary, with heights and wavelengths greater than 5 m and 130 m, respectively.  The crests of the large dunes are arrangedwith an orientation perpendicular to the axis of the channel.  From geometrical analysis of the parameters, the dunes show aweakly positive correlation between dune height and wavelength as too between dune height and water depth. No clear relationship was observed between maximumheight and wavelength parameters with water depth. Across the estuary, the bedforms migrate in the ebb direction, with mean rate of 43m year&#8722;1. Comparison of our results with previous data shows that during three decades the western boundary of dune field has been displaced 900 m towards the outer estuary, however the dune field configuration and distribution of diverse types of bedform appear to be relatively stable.","palabras_clave":"ESTUARY|SUBAQUEOUS DUNES|MORPHOMETRIC|MIGRATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19608,"idioma_id":4,"titulo":"Non-plasmonic nanoantennas for surface enhanced spectroscopies with ultra-low heat conversion","resumen":"Nanoplasmonics has recently revolutionized our ability to control light on the nanoscale. Using metallic nanostructures with tailored shapes, it is possible to efficiently focus light into nanoscale field ?hot spots?. High field enhancement factors have been achieved in such optical nanoantennas, enabling transformative science in the areas of single molecule interaction, highly enhanced nonlinearities, and nanoscale waveguiding. Unfortunately, these large enhancements come with the price of high optical losses due to absorption in the metal, severely limiting real-world applications. For example, localized heating strongly limits the total power that can be delivered to a nanoscale field hot spot before the nanostructure melts and reshapes, affecting their nanoscale lighting and photonic modulation capabilities. The interaction and properties of nanoemmitters and molecules close to the nanoantennas can also be modified due to the local heat. Via the realization of a novel nanophotonic platform based on dielectric nanostructures to form efficient nanoantennas with ultra-low light-into-heat conversion, we demonstrate here an approach that overcomes these limitations. We show, that dimer-like silicon-based single nanoantennas produce both high surface enhanced fluorescence (SEF) and surface enhanced Raman scattering (SERS), while at the same time producing a negligible temperature increase in their hot spots and surrounding environments.","palabras_clave":"Nanoantenna|Nanophotonics|Silicon"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19609,"idioma_id":5,"titulo":"Una implementación implícita del modelo viscoplástico de Arruda-Boyce","resumen":"El modelo viscoplástico de Arruda-Boyce (A-B) es la piedra angular para el desarrollo de sofisticados modelos constitutivos de polímeros y tejidos blandos. Se presenta una formulación implícita simple del modelo de A-B junto con los detalles de su implementación como una rutina de material definido por el usuario de ABAQUS-Standard. La formulación hace uso de un esquema de Euler hacia atrás en combinación con procedimientos estándar para la actualización de las tensiones en la configuración relajada. Su implementación prescinde de procedimientos iterativos y del cálculo de descomposiciones polares, autovalores y matrices de rotación. Las raíces cuadradas, exponenciales y logaritmos naturales de los tensores de segundo orden se calculan utilizando aproximaciones de Padé de alto orden, mientras que la matriz de rigidez tangente se calcula utilizando un esquema de diferencias finitas. Resulta así un algoritmo simple para la actualización de las tensiones, sencillo de implementar, pero a la vez preciso y relativamente eficiente en términos de costo computacional. La precisión, la estabilidad y la eficiencia de la formulación propuesta se investigan y se demuestran con una serie de ejemplos. Como resultado, se danunaseriederecomendacionesparaajustareltaman &#771;odelincrementodedeformacióninelásticayde los residuos de los procedimientos de Newton-Raphson, y para seleccionar los algoritmos más efectivos para evaluar la matriz de rigidez tangente y resolver el sistema de ecuaciones.","palabras_clave":"Modelo Arruda-Boyce|Implementación implícita"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19610,"idioma_id":4,"titulo":"Nutrient enrichment effect on macroinvertebrates in a lowland stream of Argentina","resumen":"ABSTRACT. One of the most important effects derived from the intensive land use is the increase of nutrient concentration in the aquatic systemsdue to superficial drainage. Besides, the increment of precipitations in South America connected to the global climate change could intensify theseanthropic impacts due to the changes in the runoff pattern and a greater discharge of water in the streams and rivers. The pampean streams are singularenvironments with high natural nutrient concentrations which could be increased even more if the predictions of global climate change for the areaare met. In this context, the effect of experimental nutrient addition on macroinvertebrates in a lowland stream is studied. Samplings were carried outfrom March 2007 to February 2009 in two reaches (fertilized and unfertilized), upstream and downstream from the input of nutrients. The additionof nutrients caused an increase in the phosphorus concentration in the fertilized reach which was not observed for nitrogen concentration. Fromall macroinvertebrates studied only two taxa had significant differences in their abundance after fertilization: Corbicula fluminea and Ostracoda.Our results reveal that the disturbance caused by the increase of nutrients on the benthic community depends on basal nutrients concentration. Theweak response of macroinvertebrates to fertilization in the pampean streams could be due to their tolerance to high concentrations of nutrients inrelation to their evolutionary history in streams naturally enriched with nutrients. Further research concerning the thresholds of nutrients affectingmacroinvertebrates and about the adaptive advantages of taxa in naturally eutrophic environments is still needed. This information will allow for abetter understanding of the processes of nutrient cycling and for the construction of restoration measures in natural eutrophic ecosystems.","palabras_clave":"PHOSPHORUS|NITROGEN|FERTILIZATION|INVERTEBRATES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19611,"idioma_id":4,"titulo":"Sociocultural variables that impact high school students' perceptions of native fauna: A study on the species component of the biodiversity concept","resumen":"This study investigates the influence of school sector (private versus state schools) and student gender on knowledge of the native fauna. Our main objectives were: (a) to describe the native animal species knowledge of high school students from the province of Cordoba, Argentina, (b) to determine if any exotic species (introduced or domestic) are considered native, and (c) to analyze the effects of school sector and gender on the students´ knowledge of the native fauna. In total, 321 students aged 15-18 from fourteen urban schools (eight state and six private schools) were asked to write down ten animals native to Córdoba, Argentina in a free-list questionnaire. Relative frequencies and Generalized Linear Mixed Models (GLMM) were used to analyze the categorized (animal names) and continuous answers (quantity of responses, number of native animals, etc.), with the 25 most frequently mentioned species showing a predominance of native ones, of which 'Puma' (Puma concolor) and 'Andean condor' (Vultur gryphus) were the most prominent. An overrepresentation of mammalian species compared to other classes of chordates was also found, with high school students mentioning native and domestic species higher on the free-list. Using GLMM, we found that school sector had a significant effect on the number of native animals mentioned at both national and local levels, and on domestic and mixed species. Finally, male students mentioned more species and more native animals than their female counterparts. These findings were interpreted and discussed in light of sociocultural and traditional ecological knowledge theories, from which several implications arose related to research and practice.","palabras_clave":"Biodiversidad|Diversidad Biológica|Conocimiento Ecológico Tradicional|Estudiantes Secundarios"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19612,"idioma_id":4,"titulo":"Polarization behaviour of femtosecond laser written waveguides in lithium niobate","resumen":"In this work, we analysed the polarization of guided light in   femtosecond laser written waveguides. The studied waveguides were   performed with different laser pulse energies in an x-cut lithium   niobate crystal. The guided intensities were experimentally measured and   compared with numerical simulations reaching a qualitatively good   accordance. This comparison allowed a verification of the 'mechanical   expansion theory' which is useful to compute the refractive index field.   Also, information related to the modelling of waveguides generated with   different laser pulse energies was obtained. Both of these facts are   keys to design and manufacture optical circuits by using this   technological approach.","palabras_clave":"waveguides polarization|femtosecond writting"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19613,"idioma_id":4,"titulo":"Leftover prey remains: a new taphonomic mode from the late Miocene (Cerro Azul Formation) in central Argentina","resumen":"The Cerro Azul Formation (La Pampa Province, Argentina) comprises a rich vertebrate fauna of small mammals dominated by notoungulates and rodents. The fauna pertains to the late Miocene specifically to the Huayquerian Stage\/Age. Taphonomic analysis of micromammals from Estancia Ré locality evidenced that the faunal assemblage was accumulated by the activity of a predator. This assemblage was compared with others from the Cerro Azul Formation in Telén and Caleufú localities (La Pampa Province), previously interpreted as products of predator activities. These microfossil accumulations differ from assemblages attributed to feces and pellets produced by modern predators (nocturnal and diurnal bird raptors and carnivore mammals). However, due to their anatomical representation, degree of bone breakage, and presence of tooth marks, they are interpreted as accumulations of uneaten prey remains discarded by the predator. The predator involved could not be determined with certainty, although the presence of tooth marks in some skeletal remains and the presence of coprolites in Telén and Caleufú suggest that it could be a carnivore mammal. Similarities in the accumulation mechanism, patterns of preservation, and sedimentary contexts in the three assemblages, support the recognition of a new taphonomic mode, termed 'leftover prey remains'.","palabras_clave":"ARGENTINA|CERRO AZUL FORMATION|LATE MIOCENE|LEFTOVER PREY REMAINS|MICRO-MAMMALS|TAPHONOMIC MODE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19614,"idioma_id":4,"titulo":"Are editors of ecological journals good oracles? A reply to Schimel et al. (2014) about the malpractice of editorial rejections","resumen":"In an earlier work, we found that 66% of manuscripts that suffered editorial rejections were finally accepted in journals of similar ranking to which they were originally submitted. We thus concluded that editors appear to be ?poor oracles? with regards to being able evaluate the quality of a manuscript without the help of external reviewers. This article was recently criticized by the team of editors of the Ecological Society of America. In this work, we clarify some misunderstandings and offer new evidence supporting our view that external reviews should be the rule in the process of publishing scientific literature. Specifically, here we argue that (a) the claim that editorial rejections are based on manuscripts not adjusting to the journal?s scope rather than on academic quality is unconvincing; (b) if academic quality is being assessed to decide the fate of a submitted paper, this attribute must be evaluated including several external opinions and not only the superficial reading of one person, (c) our survey design was appropriate and, despite the small sample size, the conclusion that editors are poor oracles seems to be fairly reliable and, (d) the practice of sending the majority of submitted papers to external review should not cause the collapse of most popular journals. We insist that for the sake of science, editors need the opinion of external experts and should not act as oracles","palabras_clave":"PEER REVIEW|JOURNAL|ECOLOGY|PUBLICATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19615,"idioma_id":4,"titulo":"GERMPLASM EVALUATION OF THE NATIVE CULTIVAR 'TORRONTÉS RIOJANO' (VITIS VINIFERA L.) COLLECTED IN THE NORTHWEST OF ARGENTINA","resumen":"The cultivar ?Torrontés Riojano? (Vitis vinifera L.) was derived from a crossof ?Muscat of Alexandria? and ?Criolla Chica?. Its origin was probably not a directedcross in Mendoza Argentina during the colonial period. Related cultivars withcommon characteristics are called ?criollas?. Some are derived from the same cross,and one is a half-sister with a parent in common. ?Torrontés Riojano? is a productiveand vigorous cultivar, and usually is used to produce dry white wines with distinct?Muscat? flavor. It is spread in the Argentinean northwest wine valleys. Collectiontrips were made in summer to identify plants with morphologic variations, andothers were made during autumn and spring to eliminate plants with viral diseasesymptoms. Sixty clones were collected from 6 vineyards located in the areas wherethis cultivar is mostly cultivated, Cafayate (Salta, Argentina) and Chilecito (LaRioja, Argentina). Virus diseases were screened by ELISA tests, and sixmicrosatellites were used to confirm varietal identity: VVMD5, VVMD7, VVMD27,ssrVrZAG 62, ssrVrZAG 79 and VVS2. After that, clones were planted in triplicatein a homogeneous plot. Parameters related to cluster morphology and productivitywere measured over 2 growing seasons, 2013 and 2014. The high variabilityobserved in the collection was evidenced through the coefficients of variation. Thework is the first contribution of ?Torrontés Riojano?s germplasm and a startingpoint to hypothesize about the origin of the variability in this cultivar.","palabras_clave":"GENETIC RESOURCE|CLONE SELECTION | VARIABILITY|MOLECULAR CHARACTERIZATION|NATIVE VINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19616,"idioma_id":4,"titulo":"Mitochondrial dysfunction in skeletal muscle during experimental Chagas disease","resumen":"Trypanosoma cruzi invasion and replication in cardiomyocytes and other tissues induce cellular injuries and cytotoxic reactions, with the production of inflammatory cytokines and nitric oxide, both sources of reactive oxygen species. The myocyte response to oxidative stress involves the progression of cellular changes primarily targeting mitochondria. Similar alterations could be taking place in mitochondria from the skeletal muscle; if that is the case, a simple skeletal muscle biopsy would give information about the cardiac energetic production that could be used as a predictor of the chagasic cardiopathy evolution. Therefore, in the present paper we studied skeletal muscle mitochondrial structure and the enzymatic activity of citrate synthase and respiratory chain complexes I to IV (CI?CIV), in Albino Swiss mice infected with T. cruzi, Tulahuen strain and SGO Z12 and Lucky isolates, along the infection. Changes in the mitochondrial structure were detected in 100% of the mitochondria analyzed from the infected groups: they all presented at least 1 significant abnormality such as increase in their matrix or disorganization of their cristae, which are probably related to the enzymatic dysfunction.Whenwe studied the Krebs cycle functionality through the measurement of the specific citrate synthase activity, we found it to be significantly diminished during the acute phase of the infection in Tulahuen and SGO Z12 infected groups with respect to the control one; citrate synthase activity from the Lucky group was significantly increased (p b 0.05). The activity of this enzyme was reduced in all the infected groups during the chronic asymptomatic phase (p b 0.001) and return to normal values (Tulahuen and SGO Z12) or increased its activity (Lucky) by day 365 post-infection (p.i.). When the mitochondrial respiratory chain was analyzed from the acute to the chronic phase of the infection through the measurement of the activity of complexes I to IV, the activity of CI remained similar to control in Tulahuen and Lucky groups, but was significantly augmented in the SGO Z12 one in the acute and chronic phases (p b 0.05). CII increased its activity in Tulahuen and Lucky groups by day 75 p.i. and in SGO Z12 by day 365 p.i. (p b 0.05). CIII showed a similar behavior in the 3 infected groups, remaining similar to control values in the first two stages of the infection and significantly increasing later on (p b 0.0001). CIV showed an increase in its activity in Lucky throughout all stages of infection (p b 0.0001) and an increase in Tulahuen by day 365 days p.i. (p b 0.0001); SGO Z12 on the other hand, showed a decreased CIV activity at the same time.The structural changes in skeletal muscle mitochondria and their altered enzyme activity began in the acute phase of infection, probably modifying the ability of mitochondria to generate energy; these changes were not compensated in the rest of the phases of the infection. Chagas is a systemic disease, which produces not only heart damage but also permanent skeletal muscle alterations.","palabras_clave":"mitochondria|skeletal muscle|Chagas disease"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19617,"idioma_id":5,"titulo":"La experiencia de migración y adaptación sociocultural: Identidad, contacto y apoyo social en estudiantes universitarios migrantes","resumen":"A los fines de contribuir a una mejor adaptación  sociocultural y psicológica este trabajo se propone explorar los niveles  que los estudiantes exhiben en aspectos relacionados con la experiencia de  migración: identificación con el endogrupo y exogrupo, nivel de contacto y  apoyo social percibido, y grado de adaptación sociocultural. La muestra es de tipo no probabilística intencional compuesta por 214  estudiantes migrantes de ambos de universidades públicas y privadas  de Buenos Aires.  Los resultados muestran niveles más altos de  identificación con la sociedad de origen en comparación con la receptora; mayor  contacto y percepción de apoyo social por parte del endogrupo y niveles  considerados de adaptación sociocultural. Se registran diferencias en función  del origen interno o externo del migrante.","palabras_clave":"ADAPTACION|ESTUDIANTES|MIGRANTES|CONTACTO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19618,"idioma_id":4,"titulo":"ENVIRONMENTAL AND CLIMATIC PROXIES FOR THE CAÑADÓN ASFALTO AND NEUQUÉN BASINS (PATAGONIA, ARGENTINA). REVIEW OF MIDDLE TO UPPER JURASSIC CONTINENTAL AND NEAR COASTAL SEQUENCES","resumen":"In this review we include several proxies (sedimentology, palynology, invertebrates) from the Cañadón Asfalto and Neuquén basins, to infer the environments and regional climatic context during the Middle to Late Jurassic of Patagonia. In central Patagonia, early in the Middle Jurassic, and associated with a magmatic arc, began the sedimentary filling of Jurassic continental sub-basins in the Cañadón Asfalto Basin. Lacustrine and fluvio-deltaic sediments, bearing a continental Middle Jurassic palynobiota, correspond to the Las Chacritas Member, while the sediments and palynobiota from the Late Jurassic Puesto Almada Member (both in the Cañadón Asfalto Fm) indicate a palustrine wetland subenvironment immersed within an arid macroenvironment. Paleoinvertebrates (conchostracans and sponges) of this Formation suggest wet-dry cycles in the water bodies they inhabited. The sedimentological information together with the continental and coastal palynomorph assemblages of the back arc Neuquén Basin, allowed distinguishing a complete regressive-transgressive sequence for the Middle Jurassic Lajas Formation. For the Late Jurassic in this basin, the thick gypsum and anhydrite deposits of the evaporitic coastal Auquilco Formation, correlate with extended deposits of eolian sandstones corresponding to the Botucatú paleodesert, and a saltmarsh environment is inferred from the palynoflora. The palynologic associations from both basins indicate a regional warm climate with seasonal aridity. Climatic conditions would have been drier in the continental interior (Cañadón Asfalto Basin), with strongly seasonally distributed temperatures, and moister in the western coast of the continent (Neuquén Basin), during the marine transgressions.","palabras_clave":"Paleoenvironment|Paleoclimate|Jurassic|Cañadón Asfalto Basin|Neuquén Basin|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19619,"idioma_id":4,"titulo":"Anagrelide platelet-lowering effect is due to inhibition of both megakaryocyte maturation and proplatelet formation: insight into potential mechanisms.","resumen":"BACKGROUND AND OBJECTIVES:Anagrelide represents a treatment option for essential thrombocythemia patients. It lowers platelet counts through inhibition of megakaryocyte maturation and polyploidization, although the basis for this effect remains unclear. Based on its rapid onset of action, we assessed whether, besides blocking megakaryopoiesis, anagrelide represses proplatelet formation (PPF) and aimed to clarify the underlying mechanisms.METHODS AND RESULTS:Exposure of cord blood-derived megakaryocytes to anagrelide during late stages of culture led to a dose- and time-dependent inhibition of PPF and reduced proplatelet complexity, which were independent of the anagrelide-induced effect on megakaryocyte maturation. Whereas anagrelide was shown to phosphorylate cAMP-substrate VASP, two pharmacologic inhibitors of the cAMP pathway were completely unable to revert anagrelide-induced repression in megakaryopoiesis and PPF, suggesting these effects are unrelated to its ability to inhibit phosphodiesterase (PDE) 3. The reduction in thrombopoiesis was not the result of down-regulation of transcription factors which coordinate PPF, while the myosin pathway was identified as a candidate target, as anagrelide was shown to phosphorylate the myosin light chain and the PPF phenotype was partially rescued after inhibition of myosin activity with blebbistatin.CONCLUSIONS:The platelet-lowering effect of anagrelide results from impaired megakaryocyte maturation and reduced PPF, both of which are deregulated in essential thrombocythemia. These effects seem unrelated to PDE3 inhibition, which is responsible for anagrelide´s cardiovascular side-effects and antiplatelet activity. Further work in this field may lead to the potential development of drugs to treat thrombocytosis in myeloproliferative disorders with an improved pharmacologic profile.","palabras_clave":"ANAGRELIDE|MEGACARIOCITO|AMPc"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19620,"idioma_id":4,"titulo":"Martensitic transformation in as grown and annealed near-stoichiometric epitaxial Ni2MnGa thin films","resumen":"Magnetic shape memory nanostructures have a great potential in the field ofthe nanoactuators. The relationship between dimensionality, microstructureand magnetism characterizes the materials performance. Here, we study themartensitic transformation in supported and free-standing epitaxialNi47Mn24Ga29 films grown by sputtering on (0 0 1) MgO using a stoichiometricNi2MnGa target. The films have a Curie temperature of ~390 K and amartensitic transition temperature of ~120 K. Similar transition temperatureshave been observed in films with thicknesses of 1, 3 and 4 &#956;m. Thicker films(with longer deposition time) present a wider martensitic transformation rangethat can be associated with small gradients in their chemical concentration dueto the high vapour pressure of Mn and Ga. The magnetic anisotropy of thefilms shows a strong change below the martensitic transformation temperature.No features associated with variant reorientation induced by magnetic fieldhave been observed. Annealed films in the presence of a Ni2MnGa bulk referencechange their chemical composition to Ni49Mn26Ga25. The change in thechemical composition increases the martensitic transformation temperature,being closer to the stoichiometric compound, and reduces the transformationhysteresis. In addition, sharper transformations are obtained, which indicatethat chemical inhomogeneities and defects are removed. Our results indicatethat the properties of Ni?Mn?Ga thin films grown by sputtering can be optimized(fixing the chemical concentration and removing crystalline defects) bythe annealing process, which is promising for the development of micromagneticshape memory devices.","palabras_clave":"THIN FILMS|MARTENSITIC TRANSFORMATIONS|MATERIAL PREPARATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19622,"idioma_id":4,"titulo":"Community structure and biogeochemical  impacts of microbial life on floating pumice","resumen":"Volcanic eruptions are a widespread force of geological and ecological disturbance and present recurrent opportunities for the  study of biological responses to novel habitat formation. However, scientific study of such events is difficult given their short  duration and often distant location. Here we report results from opportunistic sampling of unique volcano-generated habitats  formed during the 2011 explosive eruption in the Puyehue-Cordón Caulle complex (Chile), when massive amounts of pumice  were ejected, creating novel floating substrata that have never before been characterized from a microbiological perspective.  DNA sequencing revealed a dynamic community of microbes that came to inhabit the pumice, with a unique composition distinct  from that of the lakes? surface waters and with suggestions of ecological convergence across lakes and sampling times. Furthermore,  biogeochemical studies of net nutrient fluxes showed that, while the fresh pumice arriving to the lakes was an initial  source of phosphorus (P), colonized pumice had high rates of nitrogen (N) and P uptake and was sufficiently abundant to represent  a significant lake-wide nutrient sink. These findings highlight the remarkable versatility of microbes in exploiting novel environments  and are consistent with a recent proposal of floating pumice as a favorable environment for the initial origins of life  on early Earth.","palabras_clave":"Cordón Caulle-Puyehue|Floating pumice|microbial community"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19623,"idioma_id":4,"titulo":"Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions","resumen":"Pathogen linear motif mimics are highly evolvable elements that facilitate rewiring of host protein interaction networks. Host linear motifs and pathogen mimics differ in sequence, leading to thermodynamic and structural differences in the resulting protein?protein interactions. Moreover, the functional output of a mimic depends on the motif and domain repertoire of the pathogen protein. Regulatory evolution mediated by linear motifs can be understood by measuring evolutionary rates, quantifying positive and negative selection and performing phylogenetic reconstructions of linear motif natural history. Convergent evolution of linear motif mimics is widespread among unrelated proteins from viral, prokaryotic and eukaryotic pathogens and can also take place within individual protein phylogenies. Statistics, biochemistry and laboratory models of infection link pathogen linear motifs to phenotypic traits such as tropism, virulence and oncogenicity. In vitro evolution experiments and analysis of natural sequences suggest that changes in linear motif composition underlie pathogen adaptation to a changing environment.","palabras_clave":"linear motifs|evolution|protein|mimicry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19624,"idioma_id":4,"titulo":"Vegetation dynamics from Lago San Martín area (Southwest Patagonia, Argentina) during the last 6500 cal B.P.","resumen":"We report a palaeoenvironmental reconstruction since 6,650 cal. BP from the Lago San Martín area, from a peat-bog sequence, Mallín Paisano Desconocido, located at 48° 58? S; 72° 14? W. Between 6650 and 4500 cal B.P. we can infer a shrub steppe dominated by Asteraceae subf. Asteroideae associated with other shrubs under relatively dry conditions, through an intensification of the westerly wind belt and a steepening in the west-east precipitation gradient. From 4500 to 3000 cal B.P. a shrub-grass steppe development suggests a slight increase in moisture conditions although the environmental conditions remain dry. Form 3000 cal BP a grass steppe represented by Poaceae and subordinated herbs developed suggesting an increase in moisture availability and weaker westerly flow precipitation. The last 400 cal B.P. was characterized by a change from grass to shrubby communities which could be related to the beginning of the Little Ice Age, whereas the last century shows signals of anthropic impact The palaeoenvironmental interpretation from Lago San Martín basin is based in moisture availability variations in relation with precipitation patterns changes of westerly origin. These trends are consistent with interpretations of records from the Andean and extra-Andean areas. The comparison with other sequences allows us to interpret the palaeoenvironmental changes in the Lago San Martín area and to integrate these variations within a regional framework interpreting them in relation to southern past climatic changes. At a regional scale the records show an increase in westerly intensity during the mid- Holocene, whereas weaker westerly flows are postulated for the late Holocene.","palabras_clave":"SOUTHERN PATAGONIA |WEST-EAST ENVIRONMENTAL GRADIENT|PALAEOENVIRONMENTAL RECONSTRUCTION|MID AND LATE HOLOCENE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19625,"idioma_id":4,"titulo":"EVIDENCE OF THE EARLIEST HUMANS IN THE SOUTHERN DESEADO MASSIF (PATAGONIA, ARGENTINA), MYLODONTIDAE, AND CHANGES IN WATER AVAILABILITY","resumen":"Mylodontidae bones from La Gruta 3 rockshelter, which date to 11,077?10,571 cal BP (9560 ± 30?9470 ± 30 14C BP) and 9539?9466 cal BP (8540 ± 30 14C BP), indicate that the extinct giant ground sloth was in the area after it was first occupied by humans during the late Pleistocene at 12,799?12,049 cal BP (10,845 ± 61?10,477 ± 56 14C BP). Sediment characteristics at La Gruta 1 and 3 rockshelters (LG1 and LG3) suggest that conditions were wetter during major periods of human occupation and this is supported by pollen data. Lacustrine silts and clays in La Barda, and La Gruta Lagoons 1 and 3, provide evidence of an arid interval prior to about 6500 cal BP (5690 ± 35 14C BP) followed by wetter conditions. This may explain why there is no evidence of humans between ca. 7760 and 5583 cal BP (7500 ± 250 and 4770 ± 25 14C BP) either at La Gruta or at La Martita and Viuda Quenzana, which are ca. 25 km away. There is considerable evidence for occupation at Viuda Quenzana after 5581 cal BP and scanty evidence for occupation at La Gruta around 3800 cal BP with more abundant evidence after 1880 cal BP. In the last 1500 years, six radiocarbon ages show that humans occupied LG1 and LG3 before (1372?1271 cal BP) and after (539?156 cal BP), but not during, the Medieval Climate Anomaly, which may have been a time of increased aridity in the area. The findings at La Gruta show that Mylodontidae was probably present in the southern Deseado Massif after the first humans arrived but data from southern Patagonia show that it became extinct soon afterwards.","palabras_clave":"MYLODONTIDAE |EARLY HUMANS|CAVES |PALEOCLIMATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19626,"idioma_id":4,"titulo":"Hemispheric specialization in affective responses, cerebral dominance for language, and handedness Lateralization of emotion, language, and dexterity","resumen":"Hemispheric specialization in affective responses has received little attention in the literature. This is a fundamental variable to understand circuit dynamics of networks subserving emotion. In this study we put to test a modified 'valence' hypothesis of emotion processing, considering that sadness and happiness are processed by each hemisphere in relation to dominance for language and handedness. Mood induction and language activation during functional magnetic resonance imaging (fMRI) were used in 20 right-handed and 20 nonright-handed subjects, focusing on interconnected regions known to play critical roles in affective responses: subgenual cingulate cortex, amygdala, and anterior insular cortex. We observed a consistent relationship between lateralization of affective processing, motor dexterity, and language in individuals with clear right-handedness. Sadness induces a greater activation of right-hemisphere cortical structures in right-handed, left-dominant individuals, which is not evident in nonright-handed subjects who show no consistent hemispheric dominance for language. In anterior insula, right-handed individuals displayed reciprocal activation of either hemisphere depending upon mood valence, whereas amygdala activation was predominantly left-sided regardless of mood valence. Nonright-handed individuals exhibited less consistent brain lateralization of affective processing regardless of language and motor dexterity lateralization. In contrast with traditional views on emotion processing lateralization, hemispheric specialization in affective responses is not a unitary process but is specific to the brain structure being activated.","palabras_clave":"AMYGDALA|ANTERIOR INSULA|EMOTION|LATERALIZATION|SUBGENUAL SINGULATE|FMRI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19627,"idioma_id":4,"titulo":"Rainfall intensity modulates the interaction between the marsh cordgrass Spartina densiflora and the mouse Akodon azarae","resumen":"Changes in rainfall patterns caused by anthropogenic global climate change or planetary-scale events, such as the El Ni&ntilde;o Southern Oscillation, can significantly affect the abundance and distribution of organisms. Despite the evidence of such effects on marine and terrestrial systems, ecological consequences of rainfall fluctuations in coastal marine ecosystems remain poorly understood. Here we evaluate the effects of rainfall intensity on the interaction between the cordgrass Spartina densiflora and Azara´s grass mouse Akodon azarae in a southwestern Atlantic salt marsh (Mar Chiquita coastal lagoon, Argentina). Field surveys showed that the abundance of A. azarae increased during rainy summers (i.e. El Ni&ntilde;o 2005 and 2007) and had lowest values during dry summers (i.e. La Ni&ntilde;a 2008). Salt content in sediment and plant tissue were negatively related with rainfall. In addition, field experiments showed that increased sediment salinity resulted in increased salt content in plant tissues. Elevated soil salinity also increased the proportion of senescent S. densiflora tissues and reduced plant growth. The consumption of S. densiflora leaves by A. azarae also decreased with increased soil salinity. The proportion of S. densiflora in feces collected during the driest summer was very small. Therefore, changes in the abundance of A. azarae could be mediated by plant-rodent trophic interaction or by plant cover changes. In conclusion, rainfall fluctuations changed the abiotic environment (i.e. salinity), decreasing primary production and indirectly modifying habitat use by the omnivore A. azarae and its trophic interaction with S. densiflora. The present study provides evidence that rainfall can modify ecological processes that affect the structure and dynamics of coastal marine ecosystems.","palabras_clave":"CLIMATE CHANGE|RAINFALL CHANGES|SPARTINA DENSIFLORA|AKODON AZARAE|HABITAT USE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19628,"idioma_id":5,"titulo":"Contexto de evaluación en clases de Ingeniería. Aportes para favorecer  el desempeño de los estudiantes","resumen":"En este trabajo nos propusimos brindar aportes orientados a promover el diseño de contextos de evaluación capaces de potenciar logros en estudiantes universitarios. Atendimos a las características que asume una situación de examen en un contexto de aprendizaje en la universidad y analizamos las percepciones de los alumnos al respecto.Trabajamos con una muestra accidental (N=11) compuesta por los estudiantes que cursaron una asignatura de lacarrera Ingeniería en Telecomunicaciones en la Universidad Nacional de Río Cuarto. Los datos fueron recabados mediante observaciones de clases y entrevistas semi-estructuradas a los estudiantes. Los resultados muestran relaciones interesantes entre las características del contexto y las percepciones que los estudiantes construyeron. En las conclusiones se incluyen orientaciones para diseñar contextos de evaluación beneficiosos para los aprendizajes.","palabras_clave":"CONTEXTO DE EVALUACIÓN |PERCEPCIONES|APRENDIZAJE |ESTUDIANTES UNIVERSITARIOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19630,"idioma_id":4,"titulo":"New age-metallicity diagnostic diagram for the Washington photometric system","resumen":"The age calibration of the Washington $delta$$T_1$ index is mainly used to estimate agesof star clusters older than 1 Gyr, no age-metallicity degeneracy effect is considered.We have profusely exploited synthetic $T_1$ versus $C-T_1$ colour magnitude diagrams aiming at exploring the intrinsic behaviour of the $delta$$T_1$ index. The analysis shows that $delta$$T_1$ varies with age and metal content as well. In general,the dependence on age weakens for ages greater than $sim$ 6 Gyr, andresults even less sensitive to age as the metallicity decreases.For ages younger than $sim$ 5 Gyr $delta$$T_1$ shows a strong correlation withboth age and metallicity. The $delta$$C$ index -defined as $delta$$T_1$for the $C$ passband- is also a combined measurement of age and metallicity.We&nbsp; introduce a new age-metallicity diagnostic diagram, $delta$$T_1$ versus$delta$$C$ - $delta$$T_1$, which has shown the ability of unambiguously providing age and metallicity estimates,&nbsp; simultaneously.&nbsp;The new procedure allows to derive ages from 1 up to 13 Gyr and metallicities [Fe\/H] from -2.0 up to +0.5 dex, and is independent of the cluster reddening and distance modulus. It does solve theconstraints found in the $delta$$T_1$ index and surpasses the performance of thestandard giant branch metallicity method. All these features make the diagnostic diagram &nbsp;a powerful tool for estimating accurate ages as well as metallicities.","palabras_clave":"cluster"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19631,"idioma_id":4,"titulo":"Classification of monovarietal Argentinean white wines by their elemental profile","resumen":"The possibility of acquire a chemometric model to classify Argentinean white wines according to their  provenance through elemental profile was assessed. A simple method for multielement determination in  wines by inductively coupled plasma mass spectrometry along with chemometric pattern-recognition  techniques is proposed. A total of 57 white wine samples of the main varieties from four winegrowing  regions of Argentina: Mendoza, Rio Negro, San Juan, and Salta, were evaluated. The results of principal  component analysis explained 95.95% of the variance data total. Linear discriminant analysis allowed  correct discrimination according to the four geographical regions evaluated, using only five ultratrace  elements (Ba, As, Pb, Mo, and Co). Discrimination rates higher than 96% for prediction and validation data  sets were reached. The outcomes emphasize the skillfulness of ICPMS elemental determination in  combination with chemometrics, for classification of white wine and show that could be a trustworthy  technique to validate the geographical origin, authenticity and quality control of wines.  © 2015 Elsevier Ltd. All rights reserved","palabras_clave":"WINE ELEMENTAL ANALYSIS|SAMPLE PREPARATION|ICPMS|PCA|DA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19632,"idioma_id":4,"titulo":"Modeling excitation-emission fluorescence matrices with pattern recognition algorithms for classification of Argentine white wines according grape variety","resumen":"This paper reports the modeling of excitation-emission matrices for classification of Argentinean white wines according to the grape variety employing chemometric tools for pattern recognition. The discriminative power of the data was first investigated using Principal Component Analysis (PCA) and Parallel Factor Analysis (PARAFAC). The score plots showed strong overlapping between classes. A forty-one samples set was partitioned into training and test sets by the Kennard-Stone algorithm. The algorithms evaluated were SIMCA, N- and U-PLS-DA and SPA-LDA. The fit of the implemented models was assessed by mean of accuracy, sensitivity and specificity. These models were then used to assign the type of grape of the wines corresponding to the twenty samples test set. The best results were obtained for U-PLS-DA and SPA-LDA with 76% and 80% accuracy. © 2015 Elsevier Ltd. All rights reserved.","palabras_clave":"Excitation-emission matrices|N-PLS-DA|SIMCA|SPA-LDA|U-PLS-DA|White wine"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19633,"idioma_id":4,"titulo":"Single-step solubilization of milk samples with N,N-dimethylformamide for inductively coupled plasma-mass spectrometry analysis and classification based on their elemental composition","resumen":"A single-step procedure for traceelements analysis of milk samples is presented. Solubilization with small amounts of dymethylformamide (DMF) was assayed prior to inductively coupled plasma mass spectrometry (ICPMS) detection with a high efficiency sample introduction system. All main instrumental conditions were optimized in order to readily introduce the samples without matrix elimination. In order to assess and mitigate matrix effects in the determination of As, Cd, Co, Cu, Eu, Ga, Gd, Ge, Mn, Mo, Nb, Nd, Ni, Pb, Pr, Rb, Sm, S, Sr, Ta, Tb, V, Zn, and Zr, matrix matching calibration with 103Rh as internal standard (IS) was performed. The obtained limits of detection were between 0.68 (Tb) and 30 (Zn) &#956;g L-1. For accuracy verification, certified Skim milk powder reference material (BCR063R) was employed. The developed method was applied to trace elements analysis of commercially available milks. Principal components analysis was used to correlate the content of trace metals with the kind of milk, obtaining a classification according to adults, baby or baby fortified milks. The outcomes highlight a simple and fast approach that could be trustworthy for routine analysis, quality control and traceability of milks.","palabras_clave":"MILK ANALYSIS |SOLUBILIZATION WITH N,N-DIMETHYLFORMAMIDE|HIGHEFFICIENCY SAMPLE INTRODUCCION SYSTEM|INDUCTIVELY COUPLED PLASMA MASSA SPECTROMETRY|PRINCIPAL COMPONENT ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19634,"idioma_id":4,"titulo":"Multiscale inorganic hierarchically materials: towards an improved orthopaedic regenerative medicine","resumen":"Bone is a biologically and structurally sophisticated multifunctional tissue. It dynamically responds to biochemical, mechanical and electrical clues by remodelling itself and accordingly the maximum strength and toughness are along the lines of the greatest applied stress. The challenge is to develop an orthopaedic biomaterial that imitates the micro- and nano-structural elements and compositions of bone to locally match the properties of the host tissue resulting in a biologically fixed implant.Looking for the ideal implant, the convergence of life and materials sciences occurs. Researchers in many different fields apply their expertise to improve implantable devices and regenerative medicine. Materials of all kinds, but especially hierarchical nano-materials, are being exploited. The application of nano-materials with hierarchical design to calcified tissue reconstructive medicine involve intricate systems including scaffolds with multifaceted shapesthat provides temporary mechanical function; materials with nano-topography modifications that guarantee their integration to tissues and that possesses functionalized surfaces to transport biologic factors to stimulate tissue growth in a controlled, safe, and rapid manner. Furthermore materials that should degrade on a timeline coordinated to the time that takes the tissues regrow, are prepared. These implantable devices are multifunctional and for its construction they involve the use of precise strategically techniques together with specific material manufacturing processes that can be integrated to achieve in the design, the required multifunctionality. For such reasons, even though the idea of displacement from synthetic implants and tissue grafts to regenerative-medicine-based tissue reconstruction has been guaranteed for well over adecade, the reality has yet to emerge. In this paper, we examine the recent approaches to create enhanced bioactive materials. Their design and manufacturing procedures as well as the experiments to integrate them into engineer hierarchical inorganic materials for their practical application in calcified tissue reparation are evaluated.","palabras_clave":"BIO-GLASS|BIOACTIVE SCAFFOLDS|BONE|HYDROXYAPATITE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19635,"idioma_id":4,"titulo":"Combined epidermal growth factor and hyaluronic acid supplementation of in vitro maturation medium and its impact on bovine oocyte proteome and competence.","resumen":"The conditions for in vitro oocyte maturation impact on cytoplasmic and nuclear processes in the oocyte. These events are differentially influenced by the nature of the maturation inducer and the presence of intact cumulus in cumulus-oocyte complexes. Epidermal growth factor is the main growth factor promoting oocyte maturation. Also, hyaluronic acid (HA) produced by cumulus cells is known to be responsible for the correct structural and functional organization of the cumulus during oocyte maturation. Therefore, we evaluated the developmental competence of bovine oocytes matured in vitro in a maturation medium supplemented with both EGF and HA, compared to FSH and fetal bovine serum (FBS). In addition, the impact of IVM conditions on the proteomic profile of metaphase II bovine oocytes was analyzed by two-dimensional electrophoresis. Cumulus-oocyte complexes were matured in two media: (1) 10 ng\/mL EGF, 15 &#956;g\/mL HA, and 100-&#956;M cysteamine and (2) 0.01 UI\/mL rh-FSH and 10% FBS. The percentages of first polar body and embryo production and the kinetics of embryo development and oocyte proteomic profiles were analyzed. Oocytes matured in the presence of EGF-HA showed an increase (6%, P < 0.05) in the percentage of polar body extrusion. The blastocyst rate was 3% (P < 0.05) higher in the FSH-FBS group, but no differences were found in the rate of expanded blastocyst neither in total embryo production between IVM conditions. Cleavage rate of oocytes matured with FSH-FBS was 5% higher (P < 0.05) with respect to EGF-HA-matured oocytes when evaluated 30 hours after fertilization. However, at Day 7, those inseminated oocytes that underwent division at a correct timing showed that although there are still early blastocysts in the FSH-FBS condition, EGF-HA embryos have developed completely into blastocysts. Still, the production rate of those embryos that achieved expansion was similar between both maturation conditions. On the other hand, noncleaved presumptive zygotes at Day 7 developed into the different stages with similar rates (&#8764;4%) independently of the medium condition. Modifications of IVM medium composition markedly affected protein profile of bovine oocytes in a differential manner. The proteomic approach revealed the presence of 68 spots in both treatments, 41 exclusively found in the FSH-FBS group and 64 exclusive for the EGF-HA group. Taken together, these results indicate that combined EGF-HA supplementation of in vitro maturation medium could be used to improve oocyte meiotic competence and ensure a better timing to develop into the blastocyst stage","palabras_clave":"EGF|HYALURONIC ACID|MATURATION|BOVINE|OOCYTE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19636,"idioma_id":4,"titulo":"Improve intra-uterine insemination in rabbits using ultra-high temperature skim milk as extender to keep semen at room temperature","resumen":"Two experiments were carried out to examine in vitro quality and in vivo fertility of rabbit semen diluted in ultra-high temperature (UHT) skim milk. In the first experiment, pooled ejaculates of 10 adult rabbits were divided in three aliquots. Each aliquot was diluted in saline solution, TrisC or UHTm extender and kept at room temperature for 24 h. Sperm quality assessment was performed during all the incubation periods. In the second experiment, 27 adult rabbit does were inseminated with semen incubated for 5 h. Embryo recovery was performed 96 h after insemination. Results showed that treatments diluted in UHTm registered the highest values of spermatozoon with total motility, intact and functional plasma membrane and greater number of embryos recovered in rabbit does. We conclude that UHT skim milk would be a good extender for improved intra-uterine insemination in rabbits and to keep sperm cells for several hours at room temperature.","palabras_clave":"artificial insemination|rabbit|ultra-high temperature milk"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19637,"idioma_id":4,"titulo":"Evaluation of Mycobacterium bovis double knockout mce2-phoP as candidate vaccine against bovine tuberculosis","resumen":"In this study, a Mycobacterium bovis knockout strain in phoP-phoR and mce2   operons was tested as an antituberculosis experimental vaccine in   animal models. The double mutant strain was significantly more   attenuated than the wild type strain in inmunocompetent and   inmunodeficient mice. Vaccination with the double mutant protected mice   against challenge with a virulent M.&nbsp;bovis strain.","palabras_clave":"Bovine tuberculosis|Mycobacterium bovis|Vaccine|phoP"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19638,"idioma_id":5,"titulo":"Entre lo público y lo privado: un análisis sobre   el teatro rioplatense de intertexto romántico (1837-1857)","resumen":"La representación de un espacio público y un espacio privado en tensión es una constante que permite delinear una herramienta metodológica para comprender y analizar el ideario político y social que se plasma en la literatura y en los dramas rioplatenses antirosistas del romanticismo rioplatense. Si lo público constituye el espacio en el cual se proyectan las construcciones de las personalidades , se delinean y ejecutan acciones sociales que se producen por fuera de la vida familiar cuya finalidad es incidir en el cuerpo político; lo privado aparecerá definido desde su oposición a lo público, como una región de la vida amparada y definida por lazos familiares y de amistad que permiten refugio de las inestabilidades y los riesgos que se producen en el espacio de la sociedad.     Esta escisión entre un mundo público y uno privado que articula la estructura profunda de los textos literarios y dramáticos del período, delimita dos zonas en las cuales el sujeto acciona atravesando las fronteras que las separan. Cada vez que atraviese una frontera, el sujeto deberá modificarse para poder subsistir en el nuevo territorio. Pero como toda frontera, aquella que marca la separación entre lo público y lo privado también se presenta como porosa: esta porosidad se pone de manifiesto cada vez que el sujeto la atraviesa pero también en los momentos en que el ámbito privado es invadido por el afuera, situación esta última que por lo general presenta derivaciones trágicas.","palabras_clave":"Teatro rioplatense|siglo XIX|orden público|orden privado"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19639,"idioma_id":4,"titulo":"Study of the structure of titanium thin films deposited with a vacuum arc as a function of the thickness","resumen":"Polycrystalline titanium thin films have been widely employed as interlayer between the substrate and different coatings in order to improve adhesion strength, corrosion resistance and wear performance, as well as to promote the growth of crystalline phases of the coating. The thickness of the Ti layer can be relevant on the behavior of the coatings, however very few studies have been carried out. In this work, the crystal structure of polycrystalline titanium films deposited with a vacuum arc discharge on monocrystalline silicon wafers (100) was studied and a dependence on the film thickness was found. The presence of the fcc phase of titanium was observed for the thinnest films with a critical thickness estimated in 300&nbsp;nm, a much larger value than those reported for other deposition processes. For larger thicknesses, the films grew as &#945;-titanium with a preferred orientation in the [100] direction. The obtained results agreed with a growth model based on the matching between the film and the substrate lattice. The characteristics of the films deposited in two steps, which had not been previously investigated, reinforced the suggested model.","palabras_clave":"TITANIUM|VACUUM ARC|fcc PHASE|THIN FILMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19640,"idioma_id":4,"titulo":"CHARACTERIZATION OF PHENOLOXIDASE ACTIVITY FROM SPIDER POLYBETES PYTHAGORICUS HEMOCYANIN","resumen":"Hemocyanin of the spiderPolybetes pythagoricus, in addition to its typical role as an oxygen transporter, also exhibits a phenoloxidase activity induced by micellar concentrations of SDS. In the present work, we found the kinetic parameters KmandVmaxofPolybetes pythagoricus hemocyanin (PpHc) PO activity to be 0.407 mM and 0.081mmolmin1 mg protein1, respectively.Dopamine was used as the substrate with SDS at afinal concentration of 10 mM and a 30-min incubation at 25°C. Conformational changes in Hc associated with the SDS treatment wereanalyzed using far-UV circular dichroism, intrinsicfluorescence and absorption spectroscopy. The secondary and tertiary structural changes ofPpHc induced by SDS led to increases ina-helical content and tryptophanfluorescence intensity. A reduction in the absorption spectrum at 340 nm in the presence of SDS was also observed. These results suggest that the SDS-induced PO activity of PpHc can be ascribed to conformational changes in the local environment of the typer-3 copper active site.","palabras_clave":"PHENOLOXIDASE|SPIDER|HEMOCYANIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19641,"idioma_id":5,"titulo":"Entre la civilización y la barbarie:  cruces y desplazamientos geográfico y culturales en el teatro colombiano  (1960- 1990)","resumen":"En el presente artículo nos proponemos realizar un recorrido por el teatro colombiano del período 1960-1990, a partir de la relación teatro y frontera, a la vez que profundizaremos en los diferentes actores sociales, políticos e históricos que inciden en la narrativización de las diferentes historias que los dramas de este periodo tematizan.","palabras_clave":"teatro colombiano|siglo XX|frontera|identidad"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19642,"idioma_id":5,"titulo":"Efecto hipolipemiante del consumo de mate en individuos dislipidémicos","resumen":"Introducción: El mate es la infusión nacional de Argentina  y sus propiedades en la salud humana no han  sido totalmente aclaradas.  Objetivos: Evaluar las modificaciones del perfil lipídico  en pacientes dislipidémicos suplementados con yerba  mate.  Métodos: Se estudiaron 121 individuos dislipidémicos  (Colesterol Total (CT), Colesterol LDL (CLDL) y\/o Triglicéridos  (TG) elevados) de ambos sexos (74 mujeres y  47 varones) entre 40 y 60 años, sin tratamiento hipolipemiante.  Luego de seis semanas de abstinencia de mate, se  analizó su perfil lipídico e índice aterogénico (IA), composición  corporal a través de antropometría y consumo  reciente de energía, nutrientes y grupos de alimentos a  través de cuestionario de frecuencia de consumo. Se indicó  el consumo diario de mate preparado con 50g o 100g  de yerba mate. Se indicó no alterar hábitos alimentarios,  tabaquismo, medicación ni ejercicio físico. Se repitieron  las determinaciones luego de seis y doce semanas. El análisis  estadístico se realizó mediante prueba T de Student  para muestras relacionadas o prueba de Wilcoxon según  normalidad de las variables (p<0,05).  Resultados: Al finalizar las doce semanas, el CT descendió  9,49% (21,66mg\/dL), CLDL descendió 11,95%  (17,96mg\/dL), CHDL descendió 3,34% (1,65mg\/dL) y el  IA descendió 6,58% (0,31 puntos), p<0,001 para todos  los casos. TG solamente disminuyeron 7,02% (10,74mg\/  dl; p=0,029) en consumidores de 50g de yerba mate. Las  variables antropométricas y nutricionales no se modificaron  significativamente.  Conclusiones: El consumo diario de mate produce una  disminución tiempo dependiente en CT y sus fracciones  en individuos dislipidémicos.","palabras_clave":"ILEX PARAGUARIENSIS|COLESTEROL|TRIGLICÉRIDOS|COLESTEROL LDL|DISLIPIDEMIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19643,"idioma_id":4,"titulo":"Interactions between Frankia BCU110501 (actinorhiza) and Gigaspora rosea (mycorrhiza) with Discaria trinervis studied by spot inoculation","resumen":"Root endosymbioses are associations between plants and soil microorganisms which contribute worldwide to plant nutrition and fitness. The most common associations is with arbuscular mycorrhizal fungi (AMF) and this is formed by the majority of land plants with fungi belonging to the Glomeromycota. Another important association is that formed by the Gram-positive actinobacteria, Frankia, and actinorhizal plants such as Discaria trinervis. In this paper we studied the effect of dual symbioses resulting from spot inoculation. This method was developed and tested to ensure actinorhizal nodule development only at the site of inoculation. Our results show that both symbioses can coexist and that AMF and Frankia can stimulate plant growth both as a single inoculum and in combination. Moreover, we suggest that there is no interference between the regulation of actinorhizal and arbuscular mycorrhizal symbiosis in D. trinervis, and that there is a synergistic effect on plant growth following the development of both symbioses","palabras_clave":"ACTINORRIZAL SYMBIOSIS|AMF|MYCORRHIZAL SYMBIOSIS|ROOT NODULATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19644,"idioma_id":4,"titulo":"The first capybaras (Rodentia, Caviidae, Hydrochoerinae) involved in  the Great American Biotic Interchange","resumen":"The new combination Phugatherium dichroplax nov. comb. (Ahearn and Lance, 1980) for the North American species ?Neochoerus? dichroplax Ahearn and Lance, 1980 and ?N.? cordobai Carranza-Castañeda and Miller, 1988 is proposed. Its biochron is here enlarged (late Early Blancan - latest Blancan; Piacenzian-Gelasian), being the youngest species of Phugatherium and thus extending the biochron of the genus into the Early Pleistocene. This is the first mention of a Pliocene South American lineage of capybaras crossing the Panamanian bridge, implying the recognition of a third lineage of capybaras involved in the Great American Biotic Interchange. The proposed North American origin of the genus Neochoerus is discussed.","palabras_clave":"Capybaras|Pliocene|North America|GABI"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19645,"idioma_id":5,"titulo":"Cambios morfológicos en el cráneo debidos a la edad en la población tardía de la Puna de Jujuy","resumen":"En el presente trabajo se evalúan los cambios que experimenta la morfología craneana por el efecto de la edad en la población tardía de la Puna de Jujuy. La muestra consistió en 372 cráneos de ambos sexos, en los cuales se determinaron cinco clases de edad (infantil, juvenil, adulto, adulto maduro y senil). Se midieron 31 variables métricas y se utilizó estadística univariada para realizar el análisis. Los cambios morfológicos producidos por la edad en los individuos puneños se manifestaron en la mayoría de las variables estudiadas. Predomina un crecimiento hasta la clase adulta y luego se produce una estabilización del crecimiento, con algunas variaciones. En los individuos adultos, los principales cambios se dan en la cara, dado que ésta posee un crecimiento más lento y por la intervención de agentes externos.","palabras_clave":"GRUPOS ETARIOS|MORFOLOGÍA CRANEANA|INDIVIDUOS PUNEÑOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19646,"idioma_id":5,"titulo":"Propiedades Morfológicas en la Parte Media de la Diáfisis del Hueso Metacarpiano III de Equino Mestizo Criollo","resumen":"El desarrollo del esqueleto es de máxima importancia en caballos de trabajo y alta competencia. Los miembros  torácicos sostienen el 60% del peso corporal y están sometidos a esfuerzos biomecánicos que los predisponen a lesiones, estando obligados  a especializarse en el apoyo. El metacarpiano III soporta la mayor carga entre los huesos del cuerpo y la sustancia compacta tiene  gran espesor dorsal y medial. Es un material complejo que posee plasticidad y fuerza considerable, con capacidad para soportar la  deformación y recuperar su forma. El objetivo de este estudio es aportar conocimientos morfológicos, aplicables a la clínica animal, del  hueso metacarpiano III de equino mestizo criollo. Se estudiaron los huesos metacarpiano III de 30 equinos hembras y machos, entre 18  meses y 5 años de edad, divididos en dos grupos etarios, provenientes del frigorífico General Pico, Las Higueras. Se determinó: peso y  longitud total; diámetro latero-medial y dorso-palmar en la parte media de la diáfisis. Al metacarpiano III izquierdo se le practicó una  osteotomía transversal en la parte media de la diáfisis para determinar: espesor de la cortical, área cortical, área medular y área total. Los  datos fueron analizados mediante técnicas de correlación y regresión lineal simple, análisis de la varianza y comparaciones múltiples de  Tukey usando el paquete estadístico InfoStat, con un nivel de significación de 0,05. Los resultados muestran que existe asociación entre  el peso versus área cortical (r= 0,76, p= 0,0001) y longitud del hueso versus área cortical (r= 0,74 p= 0,0001), el área depende linealmente  del peso y longitud del hueso (R2= 0,97, p<0,0001 y R2= 0,96, p<0,0001 respectivamente). Se comprobó que existen diferencias  significativas entre los diámetros de las áreas y espesor de los cuadrantes (p<0,0001), al contrastar los cuadrantes entre sí se observaron  diferencias a excepción del cuadrante dorsal y lateral. Existe diferencias entre las áreas de los distintos grupos etários (p= 0,0034). La  morfología tiene influencia sobre las propiedades biomecánicas del hueso.","palabras_clave":"EQUINO|HUESO METACARPIANO III|MORFOMETRIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19647,"idioma_id":4,"titulo":"Computer-aided identification of anticonvulsant  effect of natural non-nutritive sweeteners Stevioside   and Rebaudioside A","resumen":"Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert.   (Asteraceae) which have recently gained worldwide approval as non-nutritive sweeteners by the Joint Food and Agriculture Organization\/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested the aglycone steviol and several of its phase I metabolites were predicted as potential anticonvulsant agents effective in the seizure animal model Maximal Electroshock (MES) test.  Thus, aqueous infusion from S. rebaudiana was tested   in the MES test (mice, ip administration), confirming dose-dependent Anticonvulsant effect. Afterwards, isolated stevioside and rebaudioside A were tested in the MES test, with positive results. Though drug repositioning most often focuses on known therapeutics, the article illustrates the possibilities of this strategy to find new functionalities and therapeutic indications   for food constituents and natural products.","palabras_clave":"STEVIA REBAUDIANA|STEVIOSIDES|STEVIOL|EPILEPSY|ANTICONVULSANT|KNOWLEDGE-BASED DRUG REPURPOSING"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19648,"idioma_id":4,"titulo":"Medial Prefrontal Cortex Role in Recognition Memory in Rodents","resumen":"The study of the neurobiology of recognition memory, defined by the integration of the different components of experiences that support recollection of past experiences have been a challenge for memory researches for many years. In the last twenty years, with the development of the spontaneous novel object recognition task and all its variants this has started to change. The features of recognition memory include a particular object or person ('what'), the context in which the experience took place, which can be the arena itself or the location within a particular arena ('where') and the particular time at which the event occurred ('when'). This definition instead of the historical anthropocentric one allows the study of this type of episodic memory in animal models. Some forms of recognition memory that require integration of different features recruit the medial prefrontal cortex. Focusing on findings from spontaneous recognition memory tasks performed by rodents, this review concentrates on the description of previous works that have examined the role that the medial prefrontal cortex has on the different steps of recognition memory. We conclude that this structure, independently of the task used, is required at different memory stages when the task cannot be solved by a single item strategy.","palabras_clave":"mPFC|serotonin|recognition memory"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19649,"idioma_id":5,"titulo":"Avances en el desarrollo de una alternativa tecnológica para la implantación de la caña de azúcar","resumen":"A","palabras_clave":"TECNOLOGIA|IMPLANTACION|CAÑA|AZUCAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19650,"idioma_id":4,"titulo":"Identification of PSEN2 mutation p.N141I in Argentine pedigrees with early-onset  familial Alzheimer's disease.","resumen":"Presenilin2 gene (PSEN2) mutations account for &lt;5% of all early-onset familial Alzheimer'sdisease (EOFAD) cases and only 13 have strong evidence for pathogenicity. Weaimed to investigate the presence of PSEN2 mutation p.N141I and characterizethe clinical phenotypes in 2 Argentine pedigrees (AR2 and AR3) with clinicalsymptoms of EOFAD. Detailed clinical assessments and genetic screening forPSEN2 and APOE genes were carried out in 19 individuals of AR2 and AR3 families.The p.N141I mutation was identified in all affected subjects and was associatedwith prominent early onset, rapidly progressive dementia, neurologic, andbehavioral symptoms. AR2 and AR3 families share the same Volga German ancestryas all the families reported presenting this mutation. To our knowledge, thisis the first report of PSEN2 mutation p.N141I in Argentina and even more, in SouthAmerica. Our contribution increases the total number of described families carryingthis mutation and help to improve the characterization of clinical phenotype inEOFAD associated to PSEN2 mutations.","palabras_clave":"ALZHEIMER?S DISEASE|PRESENILIN|MUTATION|VOLGA GERMAN|SOUTH AMERICA|DEMENTIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19651,"idioma_id":4,"titulo":"Scintillation properties of the YVO4:Eu3+ compound in powder form: its application to dosimetry in radiation fields produced by pulsed mega-voltage photon beams","resumen":"The investigation of scintillation properties of europium doped yttrium orthovanadate shows the suitability of this material for fiber-based dose rate measurements. All measurements were carried out with a 6 MV Varian linear accelerator. The temperature dependence of the signal is lower than that of the plastic scintillators reported so far. By measuring the afterglow of probes between Linac-pulses, the signal due to the stem effect can be successfully eliminated. Comparison of depth dose profiles in a water phantom for radiation field dimensions between 1 x 1 cm2 and 10 x 10 cm2 shows that the probes are suitable for small fields having dimensions up to 1 x 1 cm2. The high light yield of probes having dimensions of 1 mm opens up the possibility for their use in spatially confined radiation fields, such as in intensity-modulated radiotherapy (IMRT) and volumemodulated radiation therapy (VMAT).","palabras_clave":"SCINTILLATION DETECTOR|FIBER-BASE DOSE RATE MEASUREMENTS|RADIOTHERAPY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19652,"idioma_id":4,"titulo":"ACUTE INTERMITTENT PORPHYRIA IN ARGENTINA. AN UPDATE","resumen":"Porphyrias are a group ofmetabolic diseases that arise from deficiencies in the heme biosyntheticpathway. A partial deficiency in hydroxymethylbilane synthase (HMBS) produces ahepatic disorder named Acute Intermittent Porphyria (AIP); the acute porphyriais more frequent in Argentina. In this paper we review the results obtained for101 Argentinean AIP families and 6 AIP families from foreign neighbourcountries studied at molecular level at Centro de Investigaciones sobre Porfirinasy Porfirias (CIPYP). Thirty-five different mutations were found, of which 14were described for the first time in our population. The most prevalent type ofmutations was the missense mutations (43%) followed by splice defects (26%) andsmall deletions (20%). An odd case of a double heterozygous presentation of AIPin a foreign family from Paraguay is discussed. Moreover, it can be noted that38 new families were found carrying the most frequent mutation in Argentina(p.G111R), increasing to 55.66% the prevalence of this genetic change in ourpopulation and adding further support to our previous hypothesis of a foundereffect for this mutation in Argentina. Identification of patients with an overtAIP is important because treatment depends on an accurate diagnosis, but morecritical is the identification of asymptomatic relatives to avoid acute attackswhich may progress to death. ","palabras_clave":"ACUTE INTERMITTENT PORPHYRIA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19653,"idioma_id":4,"titulo":"Characterization of Variegate Porphyria mutations using a minigene approach","resumen":"Porphyrias are a group of metabolic diseases that affect the skin and\/or nervous system. In 2008 three unrelated patients were diagnosed as Variegate Porphyria at the CIPYP (Centro de Investigaciones sobre Porfirinas y Porfirias). Sequencing of the protoporphirinogen oxidase gene, the gene altered in this type of porphyria, revealed three previously undescribed mutations: c.338+3insT, c.807 G>A, c.808-1 G>C. As these mutations do not affect the protein sequence we hypothesized that they might be splicing mutations. RT-PCRs performed on the patient?s mRNAs showed normal mRNA or no amplification at all. This result indicated that the aberrant spliced transcript is possibly being degraded. In order to establish whether they were responsible or not for the patient?s disease by causing aberrant splicing, we utilized a minigene approach. We found that the three mutations lead to exon skipping, therefore the abnormal mRNAs are most likely degraded by a mechanism such as nonsense mediated decay. In conclusion, these mutations are responsible for the disease because they alter the normal splicing pathway, thus providing a functional explanation for the appearance of disease and highlighting the use of minigene assays to complement transcript analysis.","palabras_clave":"PORPHYRIAS|VARIEGATE PORPHYRIA|MUTATION|MINIGENE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19654,"idioma_id":4,"titulo":"Lack of oestrogenic inhibition of the NF-&#954;B Pathway in somatolactotroph tumour cells.","resumen":"Activation of NF-&#954;B promotes cell proliferation and inhibits apoptosis. We have previously shown that oestrogens sensitise normal anterior pituitary cells to the apoptotic effect of TNF-&#945; by inhibiting NF-&#954;B nuclear translocation. In the present report we examined whether oestrogens also modulate NF-&#954;B signalling pathway and apoptosis in GH3 cells, a rat somatolactotroph tumour cell line. As determined by Western blot, 17&#946;-oestradiol (E2 , 10-9 M) increased nuclear concentration of NF-&#954;B\/p105, p65 and p50 in GH3 cells. However, E2 did not modify expression of Bcl-xL, a NF-&#954;B target gene. TNF-&#945; induced apoptosis of GH3 cells incubated in either presence or absence of E2 . BAY 11-7082 (BAY, 5 &#956;M), Inhibition of the NF-&#954;B pathway using BAY 11-7082 (BAY) decreased viability of GH3 cells and increased the percentage of TUNEL-positive GH3 cells. BAYalso increased TNF-&#945;-induced apoptosis of GH3 cells, an effect that was further increased by an inhibitor of the JNK pathway, SP 600125 (10 &#956;M). We also analysed the role of NF-&#954;B signalling pathway on proliferation and apoptosis of GH3 tumours in vivo. The administration of BAY to nude mice bearing GH3 tumours increased the number of TUNEL-positive cells and decreased the number of proliferating GH3 cells. These findings suggest that GH3 cells lose their oestrogenic inhibitory action on NF-&#954;B pathway and that the pro-apoptotic effect of TNF-&#945; on these tumour pituitary cells does not require sensitisation by oestrogens as happens in normal pituitary cells. NF-&#954;B was required for survival of GH3 cells suggesting that pharmacological inhibition of NF-&#954;B pathway could interfere with pituitary tumour progression. This article is protected by copyright. All rights reserved.","palabras_clave":"APOPTOSIS|NF-kB|OESTROGENS|PITUITARY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19655,"idioma_id":4,"titulo":"PERFLUOROALKYLATION REACTIONS OF (HETERO)ARENES","resumen":"Perfluoroalkylation reactions of arenes have not been the subject of intense study as has been the case forthe trifluoromethylation reactions of aromatics. However, the new synthetic methods proposed forachieving homolytic aromatic substitution reactions with perfluoroalkyl moieties have begun to claim arelevant role in functionalization reactions, as revealed by the interesting properties of arenes with largeperfluoroalkyl chains. Methods for achieving Ar?Rf bonding reactions can be classified into thermal andphotochemical, which can in turn make use of transition metals or be non-metal catalyzed. Reactionsare mainly radical in nature. Radical methods for introducing Rf moieties into arenes have resulted asbeing the most popular and versatile options available to synthetic chemists.","palabras_clave":"Perfluoroalkylation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19656,"idioma_id":4,"titulo":"The neuronal ceroid lipofuscinoses program: A translational research experience in Argentina","resumen":"Background The Argentinean program was initiated more than a decade ago as the first experience of systematic translational research focused on NCL in Latin America. The aim was to overcome misdiagnoses and underdiagnoses in the region.  Subjects  216 NCL suspected individuals from 8 different countries and their direct family members.  Methods  Clinical assessment, enzyme testing, electron microscopy, and DNA screening.  Results and discussion  1) The study confirmed NCL disease in 122 subjects. Phenotypic studies comprised epileptic seizures and movement disorders, ophthalmology, neurophysiology, image analysis, rating scales, enzyme testing, and electron microscopy, carried out under a consensus algorithm; 2) DNA screening and validation of mutations in genes PPT1 (CLN1), TPP1 (CLN2), CLN3, CLN5, CLN6, MFSD8 (CLN7), and CLN8: characterization of variant types, novel\/known mutations and polymorphisms; 3) Progress of the epidemiological picture in Latin America; and 4) NCL-like pathology studies in progress. The Translational Research Program was highly efficient in addressing the misdiagnosis\/underdiagnosis in the NCL disorders. The study of ?orphan diseases? in a public administrated hospital should be adopted by the health systems, as it positively impacts upon the family´s quality of life, the collection of epidemiological data, and triggers research advances. This article is part of a Special Issue entitled: ?Current Research on the Neuronal Ceroid Lipofuscinoses (Batten Disease)?.","palabras_clave":"NEURONAL CEROID LIPOFUSCINOSES|ALGORITHM|MORPHOLOGY|ENZYMES|DNA VARIANTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19657,"idioma_id":4,"titulo":"Guidelines for incorporating scientific knowledge and practice on rare diseases into higher education: neuronal ceroid lipofuscinoses as a model disorder","resumen":"This article addresses the educational issues associated with rare diseases (RD) and in particular the Neuronal Ceroid Lipofuscinoses (NCLs, or CLN diseases) in the curricula of Health Sciences and Professional´s Training Programs. Our aim is to develop guidelines for improving scientific knowledge and practice in higher education and continuous learning programs.Rare diseases (RD) are collectively common in the general population with 1 in 17 people affected by a RD in their lifetime. Inherited defects in genes involved in metabolism are the commonest group of RD with over 8000 known inborn errors of metabolism. The majority of these diseases are neurodegenerative including the NCLs. Any professional training program on NCL must take into account the medical, social and economic burdens related to RDs. To address these challenges and find solutions to them it is necessary that individuals in the government and administrative authorities, academia, teaching hospitals and medical schools, the pharmaceutical industry, investment community and patient advocacy groups all work together to achieve these goals.The logistical issues of including RD lectures in university curricula and in continuing medical education should reflect its complex nature. To evaluate the state of education in the RD field, a summary should be periodically up dated in order to assess the progress achieved in each country that signed up to the international conventions addressing RD issues in society. It is anticipated that auditing current practice will lead to higher standards and provide a framework for those educators involved in establishing RD teaching programs world-wide.","palabras_clave":"RARE DISEASE|NEURONAL CEROID LIPOFUSCINOSES|EDUCATION|RESEARCH|TRAINING|ADVOCACY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19658,"idioma_id":4,"titulo":"An Extended Star Formation History in an Ultra Compact Dwarf","resumen":"There has been significant controversy over the mechanisms responsible for forming compact stellar systems like ultra compact dwarfs (UCDs), with suggestions that UCDs are simply the high mass extension of the globular cluster (GC) population, or alternatively, the liberated nuclei of galaxies tidally stripped by larger companions. Definitive examples of UCDs formed by either route have been difficult to find, with only a handful of persuasive examples of stripped-nucleus type UCDs being known. In this paper we present very deep Gemini\/GMOS spectroscopic observations of the suspected stripped nucleus UCD NGC 4546-UCD1 taken in good seeing conditions (0.7''). With these data we examine the spatially resolved kinematics and star formation history of this unusual object. We find no evidence of a rise in the central velocity dispersion of the UCD, suggesting that this UCD lacks a massive central black hole like those found in some other compact stellar systems, a conclusion confirmed by detailed dynamical modelling. Finally we are able to use our extremely high signal to noise spectrum to detect a temporally extended star formation history for this UCD. We find that the UCD was forming stars since the earliest epochs until at least 1-2 Gyr ago. Taken together these observations confirm that NGC 4546-UCD1 is the remnant nucleus of a nucleated dwarf galaxy that was tidally destroyed by NGC 4546 withinthe last 1-2 Gyr.","palabras_clave":"STAR CLUSTERS|DWARF|GALAXIES: FORMATION|GALAXIES: EVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19659,"idioma_id":4,"titulo":"Induced folding in RNA recognition by Arabidopsis thaliana DCL1","resumen":"DCL1 is the ribonuclease that carries out miRNA biogenesis in plants. The enzyme has two tandem double stranded RNA binding domains (dsRBDs) in its C-terminus. Here we show that the first of these domains binds precursor RNA fragments when isolated and cooperates with the second domain in the recognition of substrate RNA. Remarkably, despite showing RNA binding activity, this domain is intrinsically disordered. We found that it acquires a folded conformation when bound to its substrate, being the first report of a complete dsRBD folding upon binding. The free unfolded form shows tendency to adopt folded conformations, and goes through an unfolded bound state prior to the folding event. The significance of these results is discussed by comparison with the behavior of other dsRBDs.","palabras_clave":"DCL1|miRNA|dsRBDs|INTRINSICALLY DISORDERED"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19660,"idioma_id":4,"titulo":"Influence of vulcanization temperature on the cure kinetics and on the microstructural properties in natural rubber\/styrene-butadiene rubber blends prepared by solution mixing","resumen":"Blends of natural rubber and styrene-butadiene rubber were prepared by solution mixing and vulcanized with a system sulfur-accelerator at 433 K and 443 K in order to study the vulcanization kinetic and the influence of the vulcanization temperature on the final structure of the blends. The kinetic of vulcanization was analyzed under the frame of the Han´s model, which takes into account the reversion effect once the time to achieve the maximum torque in the rheometer curves is surpassed. The crosslink density was also determined in all samples by means of swelling in solvent. The average free nanohole volume was estimated using positron annihilation lifetime spectroscopy. When changing the vulcanization temperature of the blends, remarkable changes in the crosslink densities and the free nanohole volumes were detected. Furthermore, a correlation between the average fractional free nanohole volume and the fraction of polymer in the swollen state was established.","palabras_clave":"NR|PALS|RUBBER BLENDS|SBR|SWELLING|VULCANIZATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19661,"idioma_id":4,"titulo":"Reproductive disorders in obesity","resumen":"Obesity is a major international problem related to many reproductive health problems. It is associated with multiple adverse reproductive outcomes such as infertility, ovulation dysfunction, miscarriage, preeclampsia, gestational diabetes mellitus, preterm delivery, operative delivery, and fetal growth disorders. Despite this, there is no absolute consensus about the effect of obesity on infertility treatment specially because it is unclear which mechanism contributes the most to subfecundity, and it is likely a cumulative process. Female obesity adversely affects reproductive function through alterations in the hypothalamic- pituitary-ovarian axis, oocyte quality, and endometrial receptivity. Once pregnant, the obese women have higher risk of adverse pregnancy outcomes. Weight loss improves reproductive potential in obese patients, however, changing eating behavior and maintenance of ideal weight is difficult and hard to achieve not only per se but also because many of the infertile patients who attend infertility clinics at an age >30 years may not have much time to wait until they can lose weight because age itself is the major factor of declining fertility. This makes it imperative to find a consensus for medical treatment of obese patients. Obstetrician gynecologists need to be aware of the negative impact of obesity on reproductive function so that they appropriately counsel their patients. Further work is needed to clarify the underlying physiopathology responsible for adverse effects of obesity on reproduction so that novel treatment approaches may be developed.","palabras_clave":"OBESITY|OVARY|UTERUS|PREGNANCY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19662,"idioma_id":4,"titulo":"Productive and income contributions of sheep, goat and cattle, and different diversification schemes in smallholder production systems of Northern Patagonia, Argentina","resumen":"Wool production oriented sheep keeping is the  most important rural activity in Patagonia, Argentina, followed  by goat and at a lower extent cattle production. The existing  perception on the smallholder production systems from most  decision makers (e.g., policy) is that they are marginal, with  low productivity and have negative returns. Since the Argentinean  economic scenario has changed drastically in the last  decade, the aim of this study was to analyze the economic and  productive contribution of different livestock species in smallholdings.  The results showed that the post-1990?s economic  scenario turned most smallholder livestock systems to have  positive economic performance, but there were still productive  restrictions that limited to fully benefit from these favorable  circumstances. Goats were the most profitable livestock  due to their higher productive performance, followed by sheep  and cattle, with poorer performances. A strong cooperation  between the intervention programs and research institutions  is recommended to overcome the current production bottlenecks,  by focusing on cattle and sheep production systems.","palabras_clave":"Diversification|Household |Livestock |Rangeland"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19663,"idioma_id":4,"titulo":"Fatty acid composition of soybean\/sunflower mix oil, fish oil and butterfat applying the AOCS Ce 1j-07 method with a modified temperature program","resumen":"Gas-Liquid Chromatography (GLC) methods such as AOAC Fat in foods 966.06 (2005), AOCS Official Methods Ce 1h-05 (2005), Ce 1j-07 (2007), allow for analyzing the fatty acids (FAs) in dietary fats using highly polar liquid phase capillary columns. However, there are still difficulties in completely separating butiric acid from solvent, FA critical pairs with similar polarity, conjugated linoleic acid (CLA) isomers, and long chain polyunsaturated FAs (LC-PUFAs). Therefore, the selection of the temperature program to be employed is important. This work aimed to improve the AOCS Ce 1j-07 Method for the FA composition of a mixture of soybean and sunflower oil, fish oil, and butterfat, using a modified temperature program, tested among five laboratories. It takes more time, but it allows to completely separate butyric acid from the solvent, trans-18:1 from cis-18:1, 20:1 isomers from 18:3 n-3, 22:1 n-9 from 20:4 n-6, 20:5 n-3 from 24:0 and the main CLA isomers, thus permitting FA quantification in fats and oils for different purposes such as nutritional labeling, quality control and research.&nbsp;","palabras_clave":"AOCS Ce 1j-07 Method|Butterfat|Fatty acid composition|Soybean\/sunflower oil mixture"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19664,"idioma_id":4,"titulo":"Refining of AZ91 magnesium alloy obtained in machining chips recycling","resumen":"In the last years the interest in the recycling and re-use of magnesium alloys was increased. AZ91 magnesium alloy is the most widely applied.  Recycled magnesium alloys have different disadvantages for your re-use.  This paper presents results obtained in the refining of AZ91 alloy, previously obtained in recycling of machining chips.  The percentage recovery of refined process is 90%. Fluxes used permit a partial refined, since the microstructures presents a notable decrease of inclusions and porosities, but the chemical compositions of refined alloys does not match with the standard values.","palabras_clave":"CHIPS|RECYCLED|REFINING|AZ91 MAGNESIUM ALLOY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19665,"idioma_id":4,"titulo":"Use of entomopathogenic fungi combined with biorational insecticides to control Dichroplus maculipennis (Orthoptera: Acrididae: Melanoplinae) under semi-field conditions","resumen":"Grasshoppers are among the invertebrate herbivores that cause most economic losses in grasslands throughout Argentina´s Pampas and parts of Patagonia. Chemical insecticides remain the sole option for grasshopper control in this area, despite being of significant environmental concern. Our aim was to evaluate the efficacy of combinations between three entomopathogenic fungi strains (Beauveria bassiana LPSc 1067 and LPSc1082), and Metarhizium anisopliae (LPSc 907), two biorational insecticides (luphenuron and methoxyfenozide), and a new synthetic chemical pesticide (rynaxypyr) in the control of the pest grasshopper Dichroplus maculipennis under field cage conditions. Fungal strains used were adjusted to 1 x 108, 1 x 106, and 1 x 104 conidia\/ml. Insecticides were tested at three concentrations: the average concentration recommended for application in the field (100%), 50% of that level , and finally 25%. Combinations of the insecticides with B. bassiana (LPSc 1067, LPSc 1082) and M. anisopliae (LPSc 907) caused higher mortality to D. maculipennis nymphs than any of the individual agents used alone. The three insecticides tested did not negatively affect the isolates of the two species of entomopathogenic fungi employed. ","palabras_clave":"Entomopathogenic fungi|Grasshoppers|Biorational Insecticides|Beauveria bassiana|Metarhizium anisopliae"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19666,"idioma_id":4,"titulo":"Exploring the dynamics of cell processes through Monte Carlo simulations of advanced fluorescence microscopy experiments","resumen":"Fluorescence correlation spectroscopy (FCS) methods are powerful tools to unveil the dynamical organization of cells. For simple cases such as molecules passively moving in a homogeneous media, the FCS analysis yields analytical functions that can be fitted to the experimental data in order to recover the phenomenological rate parameters. Unfortunately, many dynamical processes in cells do not follow these simple models and in many instances it is not possible to obtain an analytical function through the theoretical analysis of a more complex model. In those cases, the experimental analysis can be combined with Monte Carlo simulations to help with the interpretation of the data.In response to this need, we develop here FERNET (Fluorescence Emission Recipes and Numerical routines Toolkit) a method based on Monte Carlo simulations and the MCell-Blender platform which was designed to treat the reaction-diffusion problem under realistic scenarios. This method enables us to set complex geometries of the simulation space, distribute molecules between different compartments and define interspecies reactions with selected kinetic constants, diffusion coefficient and species brightness. We apply this method to simulate single- and multiple-point FCS, photon counting histogram analysis, raster image correlation spectroscopy and two-color fluorescence cross-correlation spectroscopy. We believe that this new program could be very useful to predict and understand the output of fluorescence microscopy experiments.","palabras_clave":"Monte Carlo Simulation|Cell dynamical processes|Fluorescence correlation spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19667,"idioma_id":4,"titulo":"Resurgence of canine parvovirus 2a strain in the domestic dog  population from Argentina","resumen":"Ninety-three rectal swab samples were taken, from dogs suspected of canine parvovirus (CPV) infectionand analyzed by PCR. A fragment of the VP2 gene, was amplified in 41 (44%) of them, resulting CPVpositive samples. Sequencing analysis of these PCR products showed that 37 samples (90.2%) belongedto the CPV2c type, whereas four samples (9.8%) were identified as CPV2a, which has not been found since2008.It was also found that 24 out of 37 CPV2c samples (65%), carried the mutation Thr440Ala, whereas thismutation was absent in the four CPV2a strains reported herein.Using phylogenetic analysis of the full length VP2 gene, which was amplified by PCR in six local samples,it was seen that CPV2a Argentine strains reported in this study, were genetically closer to a previouslocal CPV2a isolate (year 2003) and to a South African CPV2a strain, than to any of the recently reportedUruguayan CPV2a strains.The results obtained in this work, together with those reported previously in Uruguay strongly suggestthat, in spite of the geographical proximity, wild type CPV strains undergo different evolutive pathwaysin each country, resulting in the prevalence of different strains in related dog populations.Further extensive epidemiological studies are needed in order to improve the understanding of CPVevolution.","palabras_clave":"CANINE PARVOVIRUS|SEQUENCE ANALYSIS|VIRUS EVOLUTION|VP2 GENE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19668,"idioma_id":4,"titulo":"Hydrolyzable and condensed tannins resistance in Clostridium perfringens","resumen":"Tannins added in the diet are being used to improve nutrition and health in farm animals as an alternative to antibiotic growth promoters and to control enteric clostridial diseases. However, the capacity of Clostridium perfringens to develop resistance under the selective pressure of tannins is unknown. The purpose of this study was to determine if C. perfringens possess the ability to develop resistance against tannins in comparison with antimicrobial agents. Susceptibility for 7 AGPs (antimicrobial growth promoters), 9 therapeutic antimicrobials and 2 tannin based extracts was determined for 30 C. perfringens strains isolated from poultry and cattle. Two susceptible strains were selected and cultured in presence of sub-inhibitory concentrations of tannins and AGPs for resistant sub-populations selection. Tannin resistance of C. perfringens isolates from both animal species revealed no statistically significant differences in MICs (minimum inhibitory concentration). Poultry isolates showed higher MICs to several AGPs compared with cattle isolates. All isolates were susceptible to the therapeutic antimicrobials tested, but avian isolates showed a significantly lower susceptibility to these antimicrobials which was highly correlated with an increased resistance to bacitracin and others AGPs. In-vitro selection of resistant clones suggests that C. perfringens was unable to develop resistance against tannins at least compared to AGPs like bacitracin and avilamycin. Avian origin strains, which were previously exposed to antibiotics showed higher resistance, compared to cattle origin strains. These results suggest that the evolution of resistance against tannins in C. perfringens would be more difficult and slower than to the determined AGPs.","palabras_clave":"clostridium|taninos|antibiotic resistance|poultry"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19669,"idioma_id":4,"titulo":"Functional characterization of mutants affected in the carbonic anhydrase domain of the respiratory complex I in Arabidopsis thaliana","resumen":"The NADH?ubiquinone oxidoreductase complex (complex I) (EC 1.6.5.3) is the main entrance site of electrons into the respiratory chain. In a variety of eukaryotic organisms, except animals and fungi (Opisthokonta), it contains an extra domain comprising trimers of putative &#947;?carbonic anhydrases, named the CA domain, which has been proposed to be essential for assembly of complex I. However, its physiological role in plants is not fully understood. Here, we report that Arabidopsis mutants defective in two CA subunits show an altered photorespiratory phenotype. Mutants grown in ambient air show growth retardation compared to wild?type plants, a feature that is reversed by cultivating plants in a high-CO2 atmosphere. Moreover, under photorespiratory conditions, carbon assimilation is diminished and glycine accumulates, suggesting an imbalance with respect to photorespiration. Additionally, transcript levels of specific CA subunits are reduced in plants grown under non-photorespiratory conditions. Taken together, these results suggest that the CA domain of plant complex I contributes to sustaining efficient photosynthesis under ambient (photorespiratory) conditions.","palabras_clave":"ARABIDOPSIS THALIANA|GAMMA CARBONIC ANHYDRASES|MITOCHONDRIA|PHOTORESPIRATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19671,"idioma_id":4,"titulo":"Main radiation events in Pan-Octodontoidea (Rodentia, Caviomorpha)","resumen":"Caviomorphs (South American hystricognaths) are recorded in the continent since the middle Eocene. The middleEocene?early Oligocene is considered a key moment for their evolutionary history because by the early Oligocenethey were differentiated into four superfamilies: Octodontoidea, Cavioidea, Chinchilloidea and Erethizontoidea.Due to their generalized dental patterns and abundance in the fossil record, Octodontoidea are interesting foranalysing the origin and early history of caviomorphs. The phylogenetic relationships of the earliest octodontoidsare studied herein. Results confirmed a basal caviomorph diversification in the middle Eocene (c. 45 Mya), withone lineage leading to Pan-Octodontoidea, and another leading to Erethizontoidea, Cavioidea and Chinchilloidea,which is not in accordance with analyses based on molecular data. Three major radiations were identified: thefirst one (late Eocene?\/early Oligocene?) occurred in low latitudes with the differentiation of Pan-Octodontoideaand the earliest crown-Octodontoidea. The second radiation (late Oligocene) was a large-scale South Americanevent; in the southernmost part of the continent it is recognized as the first Patagonian octodontoid radiation,which provided the characteristic high morphological disparity of the superfamily. The third radiation (late Miocene)is characterized by the replacement of ?old? by ?modern? octodontoids; the nature of this third event needs to bestudy in a broader taxonomic context.","palabras_clave":"Argentina |Diversification events|Eocene|Miocene"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19672,"idioma_id":4,"titulo":"New record for Galba neotropica (d'Orbigny, 1835) in Argentina, with a detailed analysis of its morphology and molecular characteristics","resumen":"We report for the &#64257;rst time the presence of Galba neotropica in Santa Fe province, Pampean Argentina. Until the presentwork, the identity of the intermediate host of Fasciola hepatica in this region, the most important livestock productionarea of Argentina, was unknown. This report extends the geographic distribution of G. neotropica and is the &#64257;rst to providemolecular and morphological information on this species in Argentina. During summer 2013, snails were collectedon private livestock farms with high prevalence of fasciolosis in cattle. Specimens were identi&#64257;ed by using the nuclearsequences of the internal transcribed spacers ITS-1 and ITS-2, the shell and the shape and size of the male reproductiveorgans. Molecularly, ITS-1 and ITS-2 nuclear sequences exhibit 100% nucleotide identity with G. neotropica fromLima, Peru. Morphologically, G. neotropica from Santa Fe province was indistinguishable from Galba viatrix and Galbacubensis, the other two cryptic species within this South American group of lymnaeids. The combination of molecularand morphological analyses is strongly recommended to identify lymnaeids at species level. The identity of the intermediatehost and the subsequent knowledge of its susceptibility, behaviour, distribution, ecology and biology are importantcomponents in developing e&#64256;ective measures to control fasciolosis.","palabras_clave":"CRYPTIC SPECIES|FASCIOLOSIS|INTERMEDIATE HOST|DISTRIBUTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19673,"idioma_id":4,"titulo":"Diabetes-associated changes in the foetal insulin\/insulin-like growth factor system are organ specific in rats.","resumen":"Abstract    BACKGROUND:  Diabetes in pregnancy affects fetal growth and development. The insulin\/insulin-like growth factors (IGF) system comprising insulin, IGF, their receptors, and binding proteins, has been implicated in fetal growth regulation. This study tested the hypothesis that maternal diabetes alters the fetal insulin\/IGF system in a tissue-specific manner.    METHODS:  Wistar rats were rendered diabetic by neonatal administration of streptozotocin and mated with control rats. At day 21 of gestation, the weights of fetuses, placentas, and fetal organs (heart, lung, liver, stomach, intestine, and pancreas) were determined. Maternal and fetal plasma concentrations of insulin, IGF1, and IGF2 were measured by ELISA, and expression of IGF1, IGF2, IGF1R, IGF2R, IR, IGFBP1, BP2, and BP3 in placenta and fetal organs by qPCR.    RESULTS:  The well-known increase in fetal growth in this model of mild diabetes is accompanied by elevated insulin and IGF1 levels and alterations of the insulin\/IGF system in the fetus and the placenta. These alterations were organ and gene specific. The insulin\/IGF system was generally upregulated, especially in the fetal heart, while it was downregulated in fetal lung.    CONCLUSION:  In our model of mild diabetes, the effect of maternal diabetes on fetal weight and fetal insulin\/IGF system expression is organ specific with highly sensitive organs such as lung and heart, and organs that were less affected, such as stomach.","palabras_clave":"MATERNAL DIABETES|FETUS|PLACENTA|INSULIN-IGF"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19674,"idioma_id":4,"titulo":"Valorisation of vegetable oils via metathesis reactions on solid catalysts: Cross-metathesis of methyl oleate with 1-hexene","resumen":"The activity and selectivity of silica-supported Hoveyda-Grubbs (HG) complex for the cross-metathesis of methyl oleate with 1-hexene to obtain 1-decene, methyl 9-tetradecenoate, 5-tetradecene and methyl 9-decenoate were studied in a batch reactor. The HG complex loading was varied between 0.87 and 11.6 wt%. Competitive secondary reactions were the self-metathesis of methyl oleate and the self-metathesis of 1-hexene. The yield to cross-metathesis products (&#951;_(C-M)^ ) was 47% when a 1-hexene\/methyl oleate reactant ratio (RC6\/MO) of one was employed. The &#951;_(C-M)^  value increased with increasing 1-hexene initial concentration, reaching 87% for RC6\/MO = 7. The selectivity to terminal olefins also increased at the expense of internal olefins among the cross-metathesis products when the concentration of 1-hexene was increased","palabras_clave":"CROSS METÁTESIS|METHYL OLEATE|1-HEXENE|HOVEYDA-GRUBBS CATALYST|OLEOCHEMISTRY |FAME"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19675,"idioma_id":4,"titulo":"Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein","resumen":"Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although it is an important protein for viral replication cycle, the definition of its specific role and sub cellular localization remains unclear.    In the present work we demonstrate, using imaging techniques, that VP5 is not a type II transmembrane protein but an intracellular membrane-associated protein. This finding might provide evidences of VP5 interaction with cellular proteins and its functions.","palabras_clave":"VP5 |VIRUS DE LA BURSITIS INFECCIOSA|LOCALIZACIÓN CELULAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19676,"idioma_id":4,"titulo":"Invasive pulmonary aspergillosis in a captive bird  Cyanocompsa brissonii (Cardinalidae) in Mendoza, Argentina","resumen":"Palma Leotta, M.; Pelegrina, M.; Cáceres, A.: Invasive pulmonary aspergillosis in a captive bird Cyanocompsa brissonii (Cardinalidae) in Mendoza, Argentina. Rev. vet. 26: 1, XX-XX, 2015. This report presents a case of invasive pulmonary aspergillosis in a captive bird Cyanocompsa brissonii ('ultramarine grosbeak'). The lesions observed suggest the infiltrative or superficial diffuse form of the disease, typical of the serosae and lungs. The infection and later death could be the outcome of a number of factors impairing the bird?s immunity, and so predisposing to mycosis. The organism found was identified as Aspergillus fumigatus, based on the conidiophores characteristics, justifying the histopathological diagnosis of aspergillosis. From the epidemiological point of view, C. brissonii could be considered as potential reservoir of Aspergillus spp. when considering human disease. Moreover, when released back into the wild, it must be con-sidered that disease introduction may have negatively impact on natural populations.","palabras_clave":"Cyanocompsa brissonii|Passeriformes|fungal infection|zoonotic vector"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19677,"idioma_id":4,"titulo":"Physiological bases of genetic gains in sugarcane yield in Argentina","resumen":"Breeding and management efforts during the 20th century have increased sugar yield in almost all sugarcane areas worldwide. However, a close analysis of the trends during the last decades reveals that the rate of increase in sugar yield has been actually slowing down since the 1980s. An experiment was conducted to compare sugarcane varieties representing different eras of genetic improvement in Argentina (one widely grown self-pollination variety, 11 released sugarcane hybrids and one advanced breeding hybrid) during the 2010\/11, 2011\/12 and 2012\/13 growing seasons under rainfall field conditions in Tucumán, the main sugarcane area of Argentina. The aim of the experiment was to quantify the achievements in sugarcane breeding since 1940 in Tucumán, by identifying the main crop physiological bases responsible for yield increases. Genetic gains for sugar yield were 0.08 and 0.14 Mg\/h yr for plant and ratoon cane, respectively. There was a linear increase in sugar yield, cane yield, sugar content and average stem weight with the year of release of the varieties throughout the period from 1940 to 2010. The increase in sugar yield was linearly and positively related to cane yield, sugar content and average stem weight, whereas the increase in cane yield was associated to average stem weight and not to the number of stems. Breeding also increased the total above ground dry biomass and the dry stem weight. However, the partitioning of total above ground dry biomass to stems or to sugar were not increased by breeding. These findings reveal that the varieties continuously released by Argentine sugarcane breeding programs have not reached a plateau in sugar yield.","palabras_clave":"SUGAR YIELD|CANE YIELD|AVERAGE STEM YIELD|NUMBER OF STEMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19678,"idioma_id":4,"titulo":"Preface: Shallow lakes from the Central Plains of Argentina","resumen":"This special issue of Hydrobiologia is devoted to the shallow lakes of the Central Plains of Argentina. The contributors were invited to submit papers dealing with different ecological topics including physical features, climatic and geological characteristics of the region, as well as studies focusing on aquatic communities (fish, zooplankton, phytoplankton and microbial components).","palabras_clave":"SHALLOW LAKES|PAMPA|PHYSICAL - BIOLOGICAL INTERACTIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19679,"idioma_id":5,"titulo":"Apuntes sobre memoria, historia y ciencia","resumen":"Este artículo tiene como propósito reflexionar sobre el rol de la memoria individual y\/o colectiva en tanto fuente de análisis en el trabajo de los historiadores de la ciencia. A esos fines, se propone una breve reseña conceptual sobre la memoria en tanto objeto de estudio y en tanto fuente, su relación con la historia como disciplina académica y las implicancias epistemológicas y metodológicas derivadas de la utilización de este tipo de material en el trabajo historiográfico. Para finalizar, se presentarán algunos desafíos e interrogantes que supone el trabajo sobre la memoria en la construcción de conocimiento histórico del pasado reciente de la ciencia argentina.","palabras_clave":"HISTORIA DE LA CIENCIA|ESTUDIOS DE MEMORIA|CIENCIA ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19680,"idioma_id":10,"titulo":"Fondos públicos, proyectos tecnológicos y violencia estatal: tensión de memorias de dictadura en una institución tecnocientífica argentina.","resumen":"As profundas e frequentes revisões históricas em torno da última ditadura argentina coincidem amplamente em apontar os efeitos políticos negativos e as funestas consequências econômicas e sociais do regime militar. Há poucas opiniões positivas a respeito desse período. É o caso, por exemplo, das vozes que reivindicam decisões, conjunturas e processos ligados à Comissão Nacional de Energia Atômica e à política nuclear daqueles anos. Outras vozes, por sua vez, evidenciam tensões interpretativas em torno do acontecido entre 1976 e 1983 nessa instituição tecnocientífica, explicitando o caráter aberto da história da Comissão. Tensões que provocam uma análise cujo foco são as memórias da ditadura; principalmente as memórias sobre decisões tecnológicas associadas ao desenvolvimento nuclear, ao uso dos orçamentos públicos por parte da instituição e aos efeitos da violência do Estado. Este trabalho visa apresentar tal análise, mostrando as contradições e as complexidades das diversas leituras possíveis sobre a política institucional durante o regime militar.","palabras_clave":"ARGENTINA|MEMORIA|CNEA|DITADURA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19681,"idioma_id":5,"titulo":"[Bovine herpesvirus 4 (BoHV-4): general aspects of the biology and status in Argentina]","resumen":"Bovine herpesvirus 4 (BoHV-4) has been isolated from cattle with   respiratory infections, vulvovaginitis, mastitis, abortions,   endometritis and from apparently healthy animals throughout the world.   Although it has not yet been established as causal agent of a specific   disease entity, it is primarily associated with reproductive disorders   of cattle. This virus can infect a wide range of species, either in vivo   or in vitro. Two groups of prototype strains were originated from the   first isolates: the DN599-type strains (American group) and the   Movar-type strains (European group). In Argentina, BoHV-4 was isolated   and characterized in 2007 from vaginal discharge samples taken from cows   that had aborted. So far, more than 40 isolates, mainly associated with   aborting bovine females have been registered in our country.","palabras_clave":"Bovine Herpesvirus"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19682,"idioma_id":4,"titulo":"Revision of the family Gymnophallidae Odhner, 1905 (Digenea) based on morphological and molecular data","resumen":"This paper reviews the family Gymnophallidae, recognizing as valid seven genera; four within the subfamily Gymnophallinae: Gymnophallus Odhner, 1900 (syn. Meiogymnophallus Ching, 1965), Paragymnophallus Ching, 1973, Pseudogymnophallus Hoberg, 1981, and Bartolius Cremonte, 2001, and three in the Parvatrematinae: Parvatrema Cable, 1953, Lacunovermis Ching, 1965, and Gymnophalloides Fujita, 1925. Specimens representing one species of each available genus were chosen from those well-described and non controversial species, for which strong morphological information was available, and used for molecular studies (ITS1-5.8S-ITS2-28S rDNA strands were sequenced). The presence or absence of a pars prostatica differentiates between the 2 subfamilies, Gymnophallinae and Parvatrematinae. The characters used to differentiate genera are: location of the ovary (pre-, post- or inter-testicular), size and location of the genital pore (inconspicuous and located at the anterior margin of the ventral sucker, or conspicuous and located at some distance from the anterior margin of ventral sucker), presence of caecal pockets, and presence or absence of ventral pit (a muscular structure which can be either well-developed, similar in size and musculature to the ventral sucker, or be poorly developed). The characters previously used to distinguish among genera that actually should be considered to separate species include: shape of tegument spines (broad, sharp or serrated), presence of lateral projections on the oral sucker (also called papillae or lips), shape of the seminal vesicle (unipartite or bipartite), shape of the prostatic duct (elongate or oval), presence of papillae on the genital pore, shape of the genital atrium (tubular, wide, oval), shape of the vitellaria (follicular in a variable degree, paired or single), shape of the excretory vesicle (V or Y), extension of  uterus (restricted to forebody, at hindbody or extending in both). Additionally, some of these characters may vary with the age of worm. The morphological and molecular information obtained in this resisive study provided strong support for recognizing seven valid genera in the family Gymnophallidae.","palabras_clave":"DIGENEAN|GYMNOPHALLIDAE|MOLECULAR PHYLOGENY|MOLLUSCA BIVALVIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19683,"idioma_id":4,"titulo":"Shifts in subsistence type and its impact on the human skull?s morphological integration","resumen":"Objetive: Here we evaluate morphological integration patterns and magnitudes in different skull regions, in order to detect if shifts in morphological integration are correlated to the appearance of more processed (softer) diets.  Methods: To do so, three transitional populations were analyzed, including samples from groups that inhabited the same geographical region and for which the evidence shows that major changes occurred in their subsistence mode. Ninety 3D landmarks were digitized on 357 skulls and used as the raw data to develop geometric morphometric analyses. The landmark coordinates were divided into several different regions of biomechanical interest, following a three-level hierarchically nested scheme: the whole skull, further subdivided into neurocranium (divided into the vault and basicranium), the facial (divided into the lower and upper facial), and the masticatory apparatus (divided into alveolar, temporal and temporo mandibular joint).  Results: Our results indicate that the morphological integration and variability patterns significantly vary across skull regions, but are maintained across the transitions. The alveolar border and the lower facial are the regions manifesting greater value of morphological integration and variability, while the upper facial, the temporo-mandibular joint and the basicranium are highly integrated and poorly variable.  Conclusions: The transition to softer diets increased morphological variation across cranial regions that are more exposed to masticatory strains effects.","palabras_clave":"GEOMETRIC MORPHOMETRIC|SUBSISTENCE TYPE|ECONOMIC TRANSITIONAL POPULATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19684,"idioma_id":4,"titulo":"Molecular characterization of the first bovine herpesvirus 4 (BoHV-4) strains isolated from in vitro bovine embryos production in Argentina","resumen":"Bovine herpesvirus 4 (BoHV-4) is increasingly considered as responsible for various problems of the reproductive tract. The virus infects mainly blood mononuclear cells and displays specific tropism for vascular endothelia, reproductive and fetal tissues. Epidemiological studies suggest its impact on reproductive performance, and its presence in various sites in the reproductive tract highlights its potential transmission in transfer-stage embryos. This work describes the biological and genetic characterization of BoHV-4 strains isolated from an in vitro bovine embryo production system. BoHV-4 strains were isolated in 2011 and 2013 from granulosa cells and bovine oocytes from ovary batches collected at a local abattoir, used as ?starting material? for in vitro production of bovine embryos. Compatible BoHV-4-CPE was observed in the co-culture of granulosa cells and oocytes with MDBK cells. The identity of the isolates was confirmed by PCR assays targeting three ORFs of the viral genome. The phylogenetic analyses of the strains suggest that they were evolutionary unlinked. Therefore it is possible that BoHV-4 ovary infections occurred regularly along the evolution of the virus, at least in Argentina, which can have implications in the systems of in vitro embryo production. Thus, although BoHV-4 does not appear to be a frequent risk factor for in vitro embryo production, data are still limited. This study reveals the potential of BoHV-4 transmission via embryo transfer. Moreover, the high variability among the BoHV-4 strains isolated from aborted cows in Argentina highlights the importance of further research on the role of this virus as an agent with the potential to cause reproductive disease in cattle. The genetic characterization of the isolated strains provides data to better understand the pathogenesis of BoHV-4 infections. Furthermore, it will lead to fundamental insights into the molecular aspects of the virus and the means by which these strains circulate in the herds.","palabras_clave":"BoHV-4|Bovine|Embryos|Molecular characterization"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19685,"idioma_id":5,"titulo":"Explotación de fauna dulceacuícola en el valle inferior del río Chubut (Patagonia Central) durante el Holoceno tardío","resumen":"        En este trabajo se presentan y discuten los  resultados de la ampliación del estudio arqueofaunístico  de dos sitios arqueológicos del valle inferior del río Chubut cuya cronología  se extiende entre 1500 y 1200 años AP. Estos contextos se destacan por el aprovechamiento  de fauna dulceacuícola (peces, aves y coipos) por sobre el guanaco, el recurso  principal para los cazadores-recolectores de Patagonia. Se discute su relación  con procesos de intensificación económica y factores situacionales, como  inundaciones repentinas y catastróficas.   ","palabras_clave":"EXPLOTACIÓN DE FAUNA DULCEACUÍCOLA| CAZADORES-RECOLECTORES|VALLE INFERIOR DEL RÍO CHUBUT|HOLOCENO TARDÍO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19686,"idioma_id":5,"titulo":"Peces marinos, peces fluviales: explotación diferencial por grupos cazadores-recolectores del noreste de Chubut (Patagonia central, Argentina)","resumen":"                                        La  incorporación de peces a la dieta de grupos cazadores-recolectores puede evaluarse  en función de su densidad, la disponibilidad de recursos de mayor tamaño  corporal, la tecnología disponible, entre otros. En este trabajo se aborda la variabilidad en el  registro ictiofaunístico durante el Holoceno tardío en dos áreas: el valle inferior  del río Chubut y su desembocadura y costa adyacente. De acuerdo a la  productividad ambiental, la disponibilidad de recursos de alta jerarquía y las oportunidades  de captura de peces, se genera un modelo de subsistencia que evalúa la  diversidad e importancia relativa de los peces para las dos áreas. Las  expectativas zooarqueológicas derivadas son discutidas a partir de los muestreos  faunísticos de las localidades Barranca Norte y Los Cangrejales Sur  (desembocadura y costa) y los sitios Loma Grande 1 y Cinco Esquinas 1 (valle  inferior), ubicados a unos 30 y 18 km del mar respectivamente. Los resultados arrojan  diferencias en la riqueza taxonómica de peces: en el valle predominan las  percas, mientras que en la desembocadura y costa se explotó una amplia variedad.  Se registró una importante contribución de peces en ambas áreas; sin embargo,  en los campamentos residenciales de la desembocadura los restos de peces son menos  frecuentes.                  ","palabras_clave":"SUBSISTENCIA|CAZADORES-RECOLECTORES|PATAGONIA CENTRAL|HOLOCENO TARDÍO|PECES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19687,"idioma_id":4,"titulo":"Fish and plants: The 'hidden' resources in the archaeological record of the North?central Patagonian coast (Argentina)","resumen":"Archaeological research conducted from 1990 on the Northecentral Patagonian coast showed certain discrepancies between the archaeofaunal and the human stable isotopic record. In general, zooarchaeological studies indicated that most faunal remains consisted of guanacos and mollusks, followed by pinnipeds, and small mammals, birds, and fish in very low proportions. Unexpectedly, stable isotopes (13C and 15N) from human skeletal samples indicated that all individuals´ diet included not only sea resources of high trophic level in variable proportions, but also terrestrial plants. Therefore, the need arose to investigate these differences, especially in regards to the less documented resources in the archaeological record: fish and plants. In this paper, we present the results of diverse methodological approaches used to inquire into the role these resources would have played among the native populations of the area through time. The methods include archaeofaunal and isotope analyses, gas chromatography in ceramic sherds, oral health in human samples, a distributional record of fishing and plant processing technology, and actualistic studies that explore the impact of post-depositional processes on the fish record. The results indicate that these resources were more important in the subsistence of the native populations of the study area than what was estimated a decade ago. However, plants seem to have been exploited in a higher systematic manner than fish due to the fact its presence was determined in most samples analyzed with stable isotopes and gas chromatography. For its part, fish remains were found only in some zooarchaeological assemblages and in fifty percent of the organic residues in pottery samples. The integrity of the ichthyoarchaeological record may have been altered by post-depositional processes and as well by cultural practices such as milling and processing in ceramic containers.","palabras_clave":"ARCHAEOLOGY|PATAGONIAN COAST|FISH|PLANTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19688,"idioma_id":4,"titulo":"Morphometric variations of Androlaelaps fahrenholzi (Berlese, 1911) (Mesostigmata: Laelapidae) associated with three Sigmodontinae (Rodentia: Cricetidae) from the north of Chile","resumen":"Androlaelaps fahrenholzi is a mite with a large distribution and parasitizes a wide host range;14 therefore it is exposed to a diversity of habitat provided by host species and the environment that inhabits the15 host. Hence the characteristics of the host and locations of this inhabit would cause changes in morphometry16 of the mites. The goal of this study was to evaluate morphometric variations of A. fahrenholzi associated with17 different host species and geographic localities. To evaluate morphometric differences of A. fahrenholzi18 between host species were analyzed mites collected on Phyllotis xanthopygus and Akodon albiventer from19 Putre. To evaluate morphometric differences of A. fahrenholzi between geographic localities were analyzed20 mites collected on P. darwini from three localities. 41 characters were analyzed for taxonomic variations.21 Principal Component Analysis and Discriminant Analysis revealed that A. fahrenholzi mites in the north of22 Chile comprise groups with different morphological characteristics. First, mites collected from P.23 xanthopygus are separated from those found on A. albiventer because of differences in the sizes of shields and24 certain setae. Second, the population from National Park LLanos de Challe differed from the populations of25 the other localities, which in turn did not show evident morphometric variations. These results may be26 validated with molecular researches and establish if there are subspecies or if it can be truly considered as27 different species.","palabras_clave":"CHILE|MESOSTIGMATA|MITES|MORPHOLOGY|RODENTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19689,"idioma_id":4,"titulo":"The second trapped specimen of Abrawayaomys chebezi (Rodentia, Sigmodontinae): new data about a poorly known sylvan rodent and its first record in Brazil. Mammalia","resumen":"Abrawayaomys chebezi is a spiny sigmodontinebelieved endemic to the Atlantic Forest of MisionesProvince, Argentina. The available knowledge is largelyrestricted to the holotype, the only fully vouchered specimen.Here, we detail a second specimen, a subadult maleobtained in the Parque Provincial Urugua-í (Misiones).The morphology of this animal confirms several diagnostictraits of A. chebezi, such as its smaller size relative toAbrawayaomys ruschii, the type species of the genus, andthe simplified occlusal structure of its molars. New dataon soft anatomy indicate that chebezi has a unilocularhemiglandularstomach, no gall bladder, and a complextridigitate penis with an external surface covered byrounded spines. A rich parasite assemblage includingfleas and mites was recorded from this animal. A preliminaryreview of the alpha taxonomy of Abrawayaomys suggeststhe possible existence of three different species inthe genus, one still unnamed.","palabras_clave":"Abrawayaomys ruschii|ARGENTINA|ATLANTIC FOREST|MISIONES|SIGMODONTINAE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19690,"idioma_id":4,"titulo":"A new species of Tunga perforating the osteoderms of its armadillo host in Argentina and redescription of the male of Tunga terasma","resumen":"A new species of Tunga (Siphonaptera: Tungidae) collected from armadillos from Argentina is herein described. The new species is characterized by eye large and pigmented, antennal segment II with 2 bristles, base of maxilla with 2 bristles and neosome discoid, compressed antero-posteriorly. The gravid female is located in the carapace of the host, perforating the osteoderms. The new species resembles Tunga penetrans and Tunga terasma in general appearance. However, it differs by the larger antero-posterior compression of the neosome, head more angular, manubrium with pointed proximal end and convex ventral margin (while the proximal end of manubrium rounded or slightly pointed in T. terasma, and straight ventral margin in T. penetrans and T. terasma). Also, specimens of T. penetrans have more bristles in the antennal segments II and III, as well as lack of bristles in posterior tibia. This is the first report of a species of Tunga perforating the osteoderms of its host, showing a highly specialization. Tunga terasma is recorded for the first time in Argentina; the male is redescribed and the diagnosis of the species emended. The information may be useful in epidemiological studies of the diseases caused by species of Tunga.","palabras_clave":"CHAETOPHRACTUS VELLEROSUS|ZAEDYUS PICHIY|DASYPODIDAE|SIPHONAPTERA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19691,"idioma_id":4,"titulo":"Fishtail projectile points from South America: the Brazilian record","resumen":"      The projectile points known as Fishtail or Fell  represent a specific design associated with the earliest hunter-gatherers of  the Pleistocene-Holocene transition in South America. Brazil was traditionally  considered as a marginal area of their distribution because in the past there  were only a small number of findings known, often inadequately documented. In  this paper we present a general and unified overview of the Brazilian record,  including previously unpublished metric, technological, and stylistic features.  Also, we report on new findings of fishtail points in order to expand the  amount of information currently available. Some issues related to these records  are also evaluated by comparing them with data from the Uruguayan plains and  the Argentinean pampas. The general picture that emerges after this analysis  shows a growing record of fishtail projectile points in southern Brazil,  demonstrating a significant presence of early paleo-South American populations.  ","palabras_clave":"fishtail projectile points|peopling of the americas|Brazil|Pleistocene-holocene transition"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19692,"idioma_id":4,"titulo":"Operant Self-Administration of Ethanol in Infant Rats","resumen":"The review focuses on operant self-administration of ethanol in immature, infant rats. Several methods for the analysis of ethanol intake in infants are available, yet only oral-self administration models the typical pattern of ethanol consumption found in humans. The study of ethanol intake in infants is important for our understanding of how early alcohol experiences facilitates subsequent engagement with alcohol. It seems that sensitivity to ethanol-induced operant reinforcement is found very early in life, a few hours after birth; and throughout the first three weeks of life. Most of the studies reviewed complied with most, albeit not all, of the criteria for operant behavior (e.g., greater responding than yoked controls and persistence of this difference after withholding the reinforcer). Operant self-administration of ethanol in infant rats seems to be, at least partially, mediated by endogenous opioid transmission and can be enhanced by prior exposure to ethanol. Furthermore, acquisition of ethanol-mediated operant learning seems to facilitate drug self-administration during adolescence. Relative to older subjects, infants exhibit lower sensitivity to ethanol?s sedative, hypnotic and motor impairing effects. On the other hand, they exhibit increased sensitivity to the motor stimulant and rewarding effects of ethanol. We suggest that this pattern of response to ethanol may favor the rapid acquisition of operant self-administration in infant rats.","palabras_clave":"ethanol|operant conditioning|infant rat|endogenous opioid receptors"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19693,"idioma_id":5,"titulo":"Estudio del empleo de la banca privada y la banca pública desde una óptica de demanda. El caso de las PyMES de Bahía Blanca, Argentina","resumen":"El objetivo del trabajo es estudiar las particularidades de las decisiones de financiamiento derivadas del entrelazamiento empresa-propietario, como el uso de créditos personales o de garantías personales para el financiamiento de la firma. Se analizan diferencias entre las características de empresas con esteentrelazamiento y el resto, buscando determinantes que incidan en la probabilidad de tomar este tipo de decisiones financieras. Para ello, se trabaja con una muestra de 159 pequeñas y medianas empresas (PyMEs) que desarrollan sus actividades en la zona de Bahía Blanca, Argentina. Metodológicamente, se realizan análisis bivariados, particularmente ANOVA, Pearson Chi2 y Fisher Exact test, y multivariados, comenzando con un probit simple, aplicando una restricción en la muestra y luego un probit con selección muestral. Se concluye que la tasa de reinversión de utilidades, la limitación de la responsabilidad de los propietarios mediante la forma legal, el uso de giro en descubierto y la pertenencia al sector servicios, son variables relevantes para identificar las estrategias financieras con una separación difusa entre la empresay su propietario.","palabras_clave":"banca privada|banca pública|PYMES|financiamiento"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19694,"idioma_id":5,"titulo":"Decisiones de financiamiento en PyMEs: particularidades derivadas del entrelazamiento empresa - propietario","resumen":"El objetivo del trabajo es estudiar las particularidades de las decisiones de financiamiento derivadas del entrelazamiento empresa-propietario, como el uso de créditos personales o de garantías personales para el financiamiento de la firma. Se analizan diferencias entre las características de empresas con este entrelazamiento y el resto, buscando determinantes que incidan en la probabilidad de tomar este tipo de decisiones financieras. Para ello, se trabaja con una muestra de 159 pequeñas y medianas empresas (PyMEs) que desarrollan sus actividades en la zona de Bahía Blanca, Argentina. Metodológicamente, se realizan análisis univariados, particularmente ANOVA, Pearson Chi2 y Fisher Exact test, y multivariados, comenzando con un probit simple, aplicando una restricción en la muestra y luego un probit con selección muestral. Se concluye que la tasa de reinversión de utilidades, la limitación de la responsabilidad de los propietarios mediante la forma legal, el uso de giro en descubierto y la pertenencia al sector servicios, son variables relevantes para identificar las estrategias financieras con una separación difusa entre la empresa y su propietario.","palabras_clave":"PYMES|DECISIONES DE FINANCIAMIENTO|CREDITOS PERSONALES|GARANTIAS PERSONALES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19695,"idioma_id":5,"titulo":"Predicting maize kernel number using QTL information","resumen":"--","palabras_clave":"MODELING|CROP PHYSIOLOGY|ZEA MAYS|YIELD|YIELD COMPONENTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19696,"idioma_id":4,"titulo":"Hepatitis B virus (HBV) and S-escape mutants: from the beginning until now","resumen":"Despite of the progress made in vaccine and antiviral therapy development, hepatitis B virus (HBV) infection remains a major health care problem. More than 240 million people are chronically infected worldwide showing differences in the severity of liver disease, clinical outcome and response to immune- and antiviraltherapy. Parameters associated with the host immune system (HBV specific Tand\/or B-cell repertoires, defective antigen presentation and diminished Th1\/ Th2 response ratio) and viral factors such as the HBV genotypes and their evolving variants\/mutants, have largely contributed to explaining such differences. The unique genomic structure and replication cycle of HBV provide much opportunity for mutations to occur in any of its genes undergoing selection pressures, such as those associated with the host immune system, the hepatitis B vaccine and\/ or hepatitis B immune globulin and the antiviral therapy with nucleos(t)ide analogues. Firstly, this review describes the current prevalence of S-escape mutants worldwide. Secondly, the clinical implications of such surface gene variants and the impact of universal hepatitis B vaccination on HBV mutations and genotypes are discussed. Finally, the fact that the immune escape process also extends well beyond HBV is addressed.","palabras_clave":"Hepatitis B Virus|S-Escape Mutants|HBsAg"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19697,"idioma_id":4,"titulo":"DEFECTIVE RENAL DOPAMINE FUNCTION AND SODIUM SENSITIVE     HYPERTENSION IN ADULT OVARIECTOMIZED WISTAR RATS: ROLE OF     THE CYTOCHROME P450 PATHWAY","resumen":"We have previously shown that ovariectomy in adult Wistar rats under normal sodium (NS) intake results in an overexpression of the total Na+-K+-ATPase (NKA) &#945;1-subunit (Di Ciano LA, Azurmendi PJ, Toledo JE, Oddo EM, Zotta E, Ochoa F, Arrizurieta EE, Ibarra FR. Clin Exp Hypertens 35: 475?483, 2013). Upon high sodium (HS) intake, ovariectomized (oVx) rats developed defective NKA phosphorylation, a decrease in sodium excretion, and an increment in mean blood pressure (MBP). Since NKA phosphorylation is modulated by dopamine (DA), the aim of this study was to compare the intracellular response of the renal DA system leading to NKA phosphorylation upon sodium challenge in intact female (IF) and oVx rats. In IF rats, HS caused an increase in urinary DA and sodium, in NKA phosphorylation state, in cytochrome P-4504A (CYP4A) expression, and in 20-HETE production, while MBP kept normal. Blockade of the D1 receptor (D1R) with the D1-like receptor antagonist SCH 23390 in IFHS rats shifted NKA into a more dephosphorylated state, decreased sodium excretion by 50%, and increased MBP. In oVxNS rats, D1R expression was reduced and D3R expression was increased, and under HS intake sodium excretion was lower and MBP higher than in IFHS rats (both P < 0.05), NKA was more dephosphorylated than in IFHS, and CYP4A expression or 20-HETE production did not change. Blockade of D1R in oVxHS rats changed neither NKA phosphorylation state nor sodium excretion or MBP. D2R and PKC&#945; expression did not vary among groups. The alteration of the renal DA system produced by ovariectomy could account for the defective NKA phosphorylation, the inefficient excretion of sodium load, and the development of salt-sensitive hypertension.","palabras_clave":"eicosanoides|hipertension|Na,K-ATPasa|dopamina|hormonas sexuales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19698,"idioma_id":4,"titulo":"Megakaryocytic emperipolesis and platelet function abnormalities in five patients with gray platelet syndrome.","resumen":"The gray platelet syndrome (GPS) is a rare congenital platelet disorder characterized by mild to moderate bleeding diathesis, macrothrombocytopenia and lack of azurophilic &#945;-granules in platelets. Some platelet and megakaryocyte (MK) abnormalities have been described, but confirmative studies of the defects in larger patient cohorts have not been undertaken. We studied platelet function and bone marrow (BM) features in five GPS patients with NBEAL2 autosomal recessive mutations from four unrelated families. In 3\/3 patients, we observed a defect in platelet responses to protease-activated receptor (PAR)1-activating peptide as the most consistent finding, either isolated or combined to defective responses to other agonists. A reduction of PAR1 receptors with normal expression of major glycoproteins on the platelet surface was also found. Thrombin-induced fibrinogen binding to platelets was severely impaired in 2\/2 patients. In 4\/4 patients, the BM biopsy showed fibrosis (grade 2-3) and extensive emperipolesis, with many (36-65%) MKs containing 2-4 leukocytes engulfed within the cytoplasm. Reduced immunolabeling for platelet factor 4 together with normal immunolabeling for CD63 in MKs of two patients demonstrated that GPS MKs display an alpha granule-specific defect. Increased immunolabeling for P-selectin and decreased immunolabeling for PAR1, PAR4 and c-MPL were also observed in MKs of two patients. Marked emperipolesis, specific defect of MK alpha-granule content and defect of PAR1-mediated platelet responses are present in all GPS patients that we could study in detail. These results help to further characterize the disease.","palabras_clave":"NBEAL2|GRAY PLATELET|EMPERIPOLESIS|PAR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19699,"idioma_id":4,"titulo":"Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride","resumen":"Two new potential impurities of antiarrhythmic drug substance Dronedarone Hydrochloride together  with debutyldronedarone were detected by LC?MS analysis during process development. A successful  synthetic strategy for the synthesis of these potential impurities was developed facilitating the access  to new impurity reference standards. Their synthesis and characterization are discussed in detail. The  availability of these impurity standards allowed cost reduction through the increase of process control.","palabras_clave":"Impurezas de procesos|dronedarona"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19700,"idioma_id":4,"titulo":"Grazing intensity levels influence C reservoirs of wet and mesic meadows along a precipitation gradient in Northern Patagonia","resumen":"Wet meadows are important ecosystems for forage production and as carbon&nbsp;reservoirs in semi-arid areas. In Patagonia, Argentina, large areas of wet meadows havebeen classified as overgrazed by livestock. The objective of this study was to determine&nbsp;whether long-term overgrazing has affected carbon (C) storage in plant and soil pools in&nbsp;wet and mesic meadows. The study occurred in Northern Patagonia, in three study sites&nbsp;located along a precipitation gradient. Our results indicate that long-term overgrazing&nbsp;reduced, on average, 35% of the total ecosystem C pool. There was significantly loweraboveground and belowground plant production in heavily grazed compared to lightlygrazed sites, 419±262 to 128±110 g m2year&#8722;1 and 3796±2622 to 1702±1012 g m2year&#8722;1 , respectively. Soil C concentrations were also less in heavily grazed sites (184±98 to105±58 g kg-1 at 1 m depth, respectively). The response of meadows to long-term heavy&nbsp;grazing also appear to be influenced by different levels of precipitation, with sites in drier&nbsp;areas being apparently more susceptible to overgrazing. Our results indicate that newmanagement and restoration practices are needed to stop and reverse meadow deterioration&nbsp;in degraded meadows of Northern Patagonia.","palabras_clave":"Patagonian wetlands|Patagonian meadows|Carbon storage systems|Overgrazing|Rangeland degradation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19701,"idioma_id":4,"titulo":"Trophic ecology of Mugil liza in the southern limit of its distribution (Buenos Aires, Argentina)","resumen":"ABSTRACT: In order to get knowing of the ecological habitat and feeding habits of Mugil liza on the southern coast of Buenos Aires, 65 specimens obtained during spring (November 2012) and summer (February 2013) were analyzed at two sampling sites: San Blas bay (SBB) and mouth area of the Quequén-Salado river (QSR). Specimens were measured, sexed, weighed, stomach was removed and stomach contents weighed and analyzed under stereoscopic microscope. Specimens were adults with sizes 28-49 cm and weights 380-1100 g. Population growth was higher in SBB (TW: 0.003*TL3.36), than in RQS (TW: 0.045*TL2.61). About 98% of the stomachs had stomach contents and repletion rate was between 0.4 and 1.2%. About 75% of stomach contents was composed of very fine sand with little presence of benthic organisms (algae, copepods, foraminifera), while stomachs with coarse sand and increased presence of benthic fauna were found in the remaining 25% (amphipods, bivalves, gastropods and coral organisms). Linear relationship between the weight of stomach contents and the total weight and length of the fish showed that the rates of growth (slope) were the same in both sites, but intercept values were significantly higher for San Blas bay (test parallelism; p &lt; 0.001).","palabras_clave":"MUGIL LIZA|DIET|ORGANIC MATTER|SEDIMENTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19702,"idioma_id":4,"titulo":"A Lattice Discrete Element Method to model the falling -weight Impact Test of Pmma Specimens","resumen":"It is introduced in this paper a Lattice Discrete Element Method (LDEM) to model the falling-weight impact respons of polymethyl-metacrylate (PMMA) specimens. The method exploits the inherent characteristics of discrete methods to model crack initiation and propagation by simply breaking the links between their discrete components. It results in a flexible modeling tool that is implemented using Abaqus\/Explicit. The Numerical results are validated by comparison with experimental tests. The Results are compared in terms of the time temporal evolution of the striker force and velocity, and the specimen crack patterns. The LDEM simulations are, in every case, of predictive nature. Material properties are neither left open for calibration nor used to adjust the numerical results. There is a good agreement between the experimental and the numerical results. It is shown that the proposed LDEM has the capability to capture all the main features of the events? sequence of events that occur during the experiment: the elastic specimen loading prior to the crack initiation, the nucleation and propagation of radial cracks as the test progresses, and the final failure after the rapid propagation of a circular crack that joins the radial cracks together. The effects of the variability of the material fracture toughness on the test results are  studied using a series of models with random distribution of fracture energy.","palabras_clave":"Impact test|Impact of Polymers|Discrete element method"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19703,"idioma_id":4,"titulo":"On the Feasibility of Identifying First Order Ogden Constitutive Parameters of Gelatin Gels from Flat Punch Indentation Tests","resumen":"The feasibility of extracting First Order Ogden constitutive parameters of gelatin gels from experimental flat punch indentation curves is analyzed. Eight gelatin gel samples of different formulations are evaluated. Identification of constitutive parameters is carried out by an inverse method which combines finite element modeling simulations and numerical optimization. Parameters are compared with those obtained from uniaxial compression. A parametric study of the influence of model parameters on the shape of curves and a sensitivity analysis of parameter re-identification is performed. Accurate extraction of parameters is possible if the domain in which &#61537; parameter stands is lower than 2.","palabras_clave":"INDENTATION|FINITE ELEMENT MODELING|HYPERELASTIC MODEL PARAMETERS|GELATIN GELS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19704,"idioma_id":4,"titulo":"Assembly, organization and regulation of cell surface receptors by lectin-glycan complexes","resumen":"Galectins are a family of galactoside-binding lectins carrying at least one consensus sequence in the carbohydrate-recognition domain, which interacts with certain glycans. Ligand properties such as N- and O-glycan branching, N-acetyllactosamine content and the balance of &#61537;2,3- and &#61537;2,6-linked sialic acid dramatically influence on galectin binding. The presentation of specific glycans in galectin binding partners is also critical: proper orientation and clustering of oligosaccharide ligands on multiple carbohydrate side chains would increase the binding avidity of galectins for a particular glycoconjugate. When galectins are secreted from cells, they typically concentrate on the cell surface and the local matrix, raising their local concentration. Thus, galectins can form their own multimers in the extracellular milieu, which in turn cross-link glycoconjugates from the cell surfaces producing galectin-glycan complexes -also termed lattices- that modulate intracellular signaling pathways thus regulating cellular processes such as apoptosis, proliferation, migration and angiogenesis. Subtle changes in receptor expression, protein synthesis rates, Golgi enzyme activities, metabolite concentrations supporting biosynthesis, density of glycans\/receptor, protein-protein interactions of glycoproteins above and below the plasma membrane, stoichiometry, etc. modify galectin-glycan complexes. Although galectins are key contributors to the formation of these extended glycan complexes leading to inhibition of receptor internalization by surface retention, when lattices are disrupted some galectins (galectin-3\/-4) have the ability to drive clathrin-independent mechanisms of endocytosis. Herein, we summarize data available on conspicuous galectin-glycan complexes well-characterized in this field.","palabras_clave":"GALECTINS|GLYCAN RECEPTORS|N- \/ O-GLYCOSYLATION|SURFACE RETENTION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19705,"idioma_id":4,"titulo":"The ability of Typha domingensis to accumulate and tolerate high concentrations of Cr, Ni and Zn","resumen":"The tolerance and removal efficiency of Typha  domingensis exposed to high concentrations of Cr, Ni, and  Zn in single and combined treatments were studied. Sediment  and two plants were disposed in each plastic reactor. The  treatments were 100 and 500 mg L&#8722;1 of Cr, Ni, and Zn (single  solutions); 100 mg L&#8722;1 Cr+Ni+Zn (multi-metal solutions)  and 500 mg L&#8722;1 Cr+Ni+Zn (multi-metal solutions); and a  control. Even though the concentrations studied were extremely  high, simulating an accidental metal dump, the three  metals were efficiently removed from water. The highest  removal was registered for Cr. The presence of other metals  favored Cr and did not favor Ni and Zn removal from water.  After 25 days, senescence and chlorosis of plants were observed  in Ni and Comb500 treatments, while Cr and Zn only  caused growth inhibition. T. domingensis accumulated high  metal concentrations in tissues. The roots showed higher  metal concentration than submerged parts of leaves. Cr translocation  to aerial parts was enhanced by the presence of Ni and  Zn. Our results demonstrate that in the case of an accidental  dump of high Cr, Ni, and Zn concentrations, a wetland system  dominated by T. domingensis is able to retain metals, and the  macrophyte is able to tolerate them the time necessary to  remove them from water. Thus, the environment will be  preserved since the wetland would act as a cushion.","palabras_clave":"macrophyte|tolerance|metals|effluents|phytoremediation|wetlands"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19706,"idioma_id":4,"titulo":"Influence of Typha domingensis in the removal on high P concentrations from water","resumen":"A greenhouse experiment was conducted to evaluate the removal of high P concentration from water by vegetated and unvegetated wetlands. Reactors containing 4 Kg of sediment and two plants of Typha domingensis (vegetated treatments) and reactors containing only sediment (unvegetated treatments) were arranged. Reactors were dosed with 100 and 500 mg L-1 of P-PO4. The studied concentrations tried to simulate an accidental dump. Controls without P addition were also disposed. Water samples were collected periodically and analyzed for phosphorus. Sediment (0-3 (surface), 3-7 (medium) and 7-10cm (deep)) and plant samples (roots, rhizomes, submerged leaves and aerial leaves) were collected at the beginning and at end of the experiment and were analyzed for total phosphorus. P fractionation was performed in the surface sediment layer. Relative growth rate (RGR) was calculated in each treatment considering initial and final plant height. P was efficiently removed from water in both, vegetated and unvegetated treatments. However, the major P removal was achieved in vegetated treatments. T. domingensis has a high capacity to tolerate and accumulate high P concentrations, especially in leaves, causing P accumulation in sediment to be significantly low in vegetated treatments. P accumulation was produced in the surface sediment layer (0-3cm) in all treatments, mainly retained as iron-bound P. Present results point the large removal capacity of phosphate of systems planted with T. domingensis. Therefore T. domingensis is suitable for phytoremediation practice, being capable to tolerate high P concentration.","palabras_clave":"PHOSPHORUS|MACROPHYTE|SEDIMENT|FRACTIONATION|WETLANDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19707,"idioma_id":4,"titulo":"Correlation between Fusarium graminearum and Deoxynivalenol during the 2012\/13 Wheat Fusarium Head Blight Outbreak in Argentina","resumen":"Fusarium graminearum (Schwabe) is reported as the main causal agent of Fusarium headblight in Argentina. The disease causes great losses in humid and semi-humid regions of theworld, reducing grain yield and quality. During 2012\/13 harvest season, a severe epidemicoccurred in Argentina. The aims of this work were to determine the F. graminearum incidenceand deoxynivalenol accumulation in wheat grain and flour samples obtained from twoof the main wheat growing regions from Argentina. Levels of the pathogen and deoxynivalenolcontent were correlated in heads, grains and flour. Out of 69 wheat grain samples, 55(79.7%) showed deoxynivalenol levels between 0.4 and 8.5 &#956;g\/kg. Fusarium graminearumwas the main species isolated, the isolation frequency ranged from 30 to 52% of the totalgrains analyzed. Correlations were observed between deoxynivalenol content, % of F.graminearuminfection, presence of the pathogen in heads, grain and flour.","palabras_clave":"FUSARIUM GRAMINEARUM|DEOXYNIVALENOL|FUSARIUM HEAD BLIGHT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19708,"idioma_id":4,"titulo":"Biological Control of the Chagas Disease Vector Triatoma infestans with the Entomopathogenic Fungus Beauveria bassiana Combined with an Aggregation Cue: Field, Laboratory and Mathematical Modeling Assessment","resumen":"        Background:        Current  Chagas disease vector control strategies, based on chemical insecticide  spraying, are growingly threatened by the emergence of pyrethroid-resistant Triatoma infestans populations  in  the Gran Chaco region of South America.        Methodology  and findings        We have already shown that the entomopathogenic fungus  Beauveria bassiana has the ability to  breach the insect cuticle and is effective both against pyrethroid-susceptible  and pyrethroid-resistant T. infestans,  in laboratory as well as field assays. It is also known that T. infestans cuticle lipids play a major  role as contact aggregation pheromones. We estimated the effectiveness of  pheromone-based infection boxes containing B.  bassiana spores to kill indoor bugs, and its effect on the vector  population dynamics. Laboratory assays were performed to estimate the effect of  fungal infection on female reproductive parameters. The effect of insect  exuviae as an aggregation signal in the performance of the infection boxes was estimated  both in the laboratory and in the field. We developed a stage-specific matrix  model of T. infestans to describe the  fungal infection effects on insect population dynamics, and to analyze the performance  of the biopesticide device in vector biological control.         Conclusions        The pheromone-containing infective  box is a promising new tool against indoor populations of this Chagas disease  vector, with the number of  boxes per house being the main driver of the reduction of the total domestic bug  population. This ecologically safe approach is the  first proven alternative to chemical insecticides in the control of T. infestans. The advantageous reduction  in vector population by delayed-action fungal biopesticides in a contained  environment is here first shown.   ","palabras_clave":"1|2|3|4"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19709,"idioma_id":4,"titulo":"Short-term menhaden oil rich diet changes renal lipid profile in acute kidney injury","resumen":"Weanling male Wistar rats fed a choline-deficient diet develop acute kidney injury. Menhaden oil, which is a very important source of omega-3 fatty acids, has a notorious protective effect. The mechanism of this protection is unknown; one possibility could be that menhaden oil changes renal lipid profile, with an impact on the functions of biological membranes. The aim of this work was to study the renal lipid profile in rats fed a choline-deficient diet with menhaden oil or vegetable oil as lipids. Rats were divided into 4 groups and fed four different diets for 7 days: choline-deficient or choline-supplemented diets with corn and hydrogenated oils or menhaden oil. Serum homocysteine, vitamin B12, and folic acid were analyzed. Renal lipid profile, as well as the fatty acid composition of the three oils, was measured. Choline-deficient rats fed vegetable oils showed renal cortical necrosis. Renal omega-6 fatty acids were higher in rats fed a choline-deficient diet and a choline-supplemented diet with vegetable oils, while renal omega-3 fatty acids were higher in rats fed a choline-deficient diet and a choline-supplemented diet with menhaden oil. Rats fed menhaden oil diets had higher levels of renal eicosapentaenoic and docosahexaenoic acids. Renal myristic acid was increased in rats fed menhaden oil. The lipid renal profile varied quickly according to the type of oil contented in the diet.","palabras_clave":"MENHADEN OIL|CHOLINE DEFICIENCY|FATTY ACIDS|ACUTE KIDNEY INJURY|LIPID PROFILE|OMEGA-3|OMEGA-6"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19710,"idioma_id":4,"titulo":"Disparities in birth weight and gestational age by ethnic ancestry in South American countries","resumen":"Objectives We examine disparities in birth weight and gestational age by ethnic ancestry in 2000?2011 in eight South American countries.Methods The sample included 60,480 singleton live births. Regression models were estimated to evaluate differences in birth outcomes by ethnic ancestry controlling for time trends.Results Significant disparities were found in seven countries. In four countries?Brazil, Ecuador, Uruguay, and Venezuela?we found significant disparities in both low birth weight and preterm birth. Disparities in preterm birth alone were observed in Argentina, Bolivia, and Colombia. Several differences in continuous birth weight, gestational age, and fetal growth rate were also observed.There were no systematic patterns of disparities between the evaluated ethnic ancestry groups across the study countries, in that no racial\/ethnic group consistently had the best or worst outcomes in all countries.Conclusions Racial\/ethnic disparities in infant health are common in several South American countries. Differences across countries suggest that racial\/ethnic disparities are driven by social and economic mechanisms. Researchers and policymakers should acknowledge these disparities and develop research and policy programs to effectively target them.","palabras_clave":"Health inequalities \u0002  \u0002  \u0002 |Ethnic disparities|Birth weight|South America|Gestational age \u0002"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19711,"idioma_id":4,"titulo":"Gastroschisis and young mothers: What makes them different from other mothers of the same age","resumen":"Although young maternal age has been identified as a risk factor for gastroschisis, its role remains undisclosed. To our knowledge, the differences between young mothers of infants with gastroschisis and young mothers of infants with other pregnancy outcomes have not been established. The aim of this work was to compare characteristics of young mothers whose newborn had gastroschisis with same aged mothers of malformed and nonmalformed control infants, diagnosed within the ECLAMC maternity hospital network. Methods: Data base records of live and stillborn infants of one of three groups (with isolated gastroschisis, with 1 of 5 other isolated birth defects, and nonmalformed), and whose mothers were younger than 20 years, were selected. Secular trends were obtained for all birth defects; frequencies and odds ratios (OR) of demographic and reproductive variables were compared among the 3 groups. Significantly associated variables were adjusted with a multivariate regression. Results: The association was higher with gastroschisis 1) than with other birth defects for African ancestry, smoking, adequate prenatal control and diagnosis 2) than with nonmalformed controls for maternal illnesses and alcohol 3) and than both for previous pregnancy loss and medication, mainly sex hormones. After adjustment, only previous pregnancy loss maintained its significance when compared with malformed, as well as with nonmalformed controls. Conclusion: A previous pregnancy loss was identified as the main risk factor for gastroschisis, while an increased use of sex hormones, perhaps related to the previous loss, could trigger a disruptive mechanism, due to their thrombophilic effect.","palabras_clave":"Gastroschisis|young mothers|age"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19712,"idioma_id":4,"titulo":"High Birth Prevalence Rates for Congenital Anomalies in South American Regions","resumen":"Cluster detection using spatial scan analysis may be an efficient approach to identifying environmental and\/or genetic factors involved in birth defects. This statistical method has the advantage of delimiting areas of high birth prevalence rate independent of political boundaries, which renders this approach useful for identifying etiologic factors and generating causal hypotheses regarding the specified geographic areas.We conducted an ecological study to identify regions with a high birth prevalence rates of specific isolated congenital anomalies in South America, using clinical epidemiologic data registered by the ECLAMC network. A total of 25,082 malformed newborns were ascertained from 2,557,424 births at 129 hospitals in South America between 1995 and 2012. Each case was codified as one of 17 congenital anomalies categories. We selected the following categories because they are conspicuous, have a high observational value at birth, or are of high clinical-epidemiologic value for health policy. The isolated congenital anomalies were: anencephaly, encephalocele (at any level), hydrocephaly, spina bifida (with or without hydrocephalus, at any level), microtia, cleft palate only, cleft lip only, cleft lip with cleft palate, cleft lip with or without cleft palate, esophageal atresia (with or without fistula, at any level), hypospadias (any grade), postaxial polydactyly (feet or hands), preaxial polydactyly (feet or hands), diaphragmatic hernia, omphalocele, gastroschisis, and Down syndrome.","palabras_clave":"High Birth Prevalence Rates|Congenital Anomalies |South American Regions"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19713,"idioma_id":4,"titulo":"LICHENS GROWING ON PAINTED METAL PLATES","resumen":"This study was based on the description of different species of lichens which were growing on metal plates exposed to the weather conditions in La Plata, Buenos Aires Province, Argentina. Among the six species observed, Caloplaca cinnabarina was the most common. Lichen species were identified by observation under optical microscope and chemical reactions. The chemical composition of the paint was analyzed by IRS and the metal composition of the plates by SEM and EDS. SEM analysis also revealed paint cracking around the lichen and paint particles trapped in the thallus.","palabras_clave":"Argentina|Caloplaca cinnabarina|SEM|EDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19714,"idioma_id":4,"titulo":"A New Species of Liolaemus of the Liolaemus alticolor-bibronii Group (Iguania: Liolaemidae) from Mendoza, Argentina","resumen":"We describe a new species of Liolaemus of the L. alticolor-bibronii group of the subgenus Liolaemus sensu stricto. Liolaemus bibroniihas a large geographic distribution; however, preliminary studies suggest that it comprises a species complex. The new species is pheneticallysimilar to L. bibronii and was confused with this taxon for many years. Nevertheless, the new species presents a combination of characterstates that clearly differentiate it. Also, the new taxon is distributed far from L. bibronii type locality (ca. 1,600 km). It differs from other speciesof Liolaemus in presenting a unique color pattern and a combination of morphological character states from lepidosis and morphometry.The new species inhabits pre-Andean localities in Uspallata, Las Heras department, northwest Mendoza Province, and is an insectivorousand oviparous species. With the description of this new taxon, the number of species of the L. alticolor-bibronii group rises to 30, but manypopulations still remain undescribed.","palabras_clave":"DIVERSITY|HERPETOLOGY|LIZARDS|SQUAMATA|TAXONOMY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19715,"idioma_id":4,"titulo":"Genetic characterization and field evaluation to recover parental phenotype in transgenic sugarcane: a step toward commercial release","resumen":"Sugarcane commercial variety RA 87-3was transformed with a genetic construct harboringthe epsps gene from Agrobacterium strain CP4conferring tolerance to glyphosate and nptII gene forkanamycin selection. Transformed lines were multipliedin greenhouse, and herbicide tolerance wasevaluated using different concentrations (3, 4, 8 and16 l\/ha) of glyphosate (Helm 48 %p\/v). All herbicidetolerant(HT) lines were field tested to confirmglyphosate tolerance and perform preliminary evaluationsof phenotypic resemblance to parental cultivar.All transformed lines maintained herbicide tolerance,but many showed phenotypic changes and\/or growthaberrations. Ten HT lines, showing close growthresemblance to RA 87-3, were analyzed using ninecompulsory morphologic markers proposed by theInternational Union for the Protection of New Varietiesof Plants (UPOV) and 339 molecular markers.Out of the ten HT lines tested, six showed minormorphologic and genetic variations and were selectedfor field testing over two vegetative crop cycles (plantcane and first ratoon) at two production areas inArgentina. The six field-tested HT lines were found tobe almost indistinguishable when comparing agronomicand industrial characteristics and chemicalcomposition. Stable heritance of the CP4 epsps geneand glyphosate tolerance throughout different clonalgenerations were confirmed by RT-qPCR and Southernblot. Taking into account all results, two out of thesix lines tested were selected for a possible commercialrelease. Our study confirms the utility of genetictransformation as a complementary tool to classicalbreeding procedures and highlights the usefulness ofUPOV traits together with molecular markers for earlyselections of transgenic events that closely resembletheir parental genotype.epsps gene from Agrobacterium strain CP4conferring tolerance to glyphosate and nptII gene forkanamycin selection. Transformed lines were multipliedin greenhouse, and herbicide tolerance wasevaluated using different concentrations (3, 4, 8 and16 l\/ha) of glyphosate (Helm 48 %p\/v). All herbicidetolerant(HT) lines were field tested to confirmglyphosate tolerance and perform preliminary evaluationsof phenotypic resemblance to parental cultivar.All transformed lines maintained herbicide tolerance,but many showed phenotypic changes and\/or growthaberrations. Ten HT lines, showing close growthresemblance to RA 87-3, were analyzed using ninecompulsory morphologic markers proposed by theInternational Union for the Protection of New Varietiesof Plants (UPOV) and 339 molecular markers.Out of the ten HT lines tested, six showed minormorphologic and genetic variations and were selectedfor field testing over two vegetative crop cycles (plantcane and first ratoon) at two production areas inArgentina. The six field-tested HT lines were found tobe almost indistinguishable when comparing agronomicand industrial characteristics and chemicalcomposition. Stable heritance of the CP4 epsps geneand glyphosate tolerance throughout different clonalgenerations were confirmed by RT-qPCR and Southernblot. Taking into account all results, two out of thesix lines tested were selected for a possible commercialrelease. Our study confirms the utility of genetictransformation as a complementary tool to classicalbreeding procedures and highlights the usefulness ofUPOV traits together with molecular markers for earlyselections of transgenic events that closely resembletheir parental genotype.nptII gene forkanamycin selection. Transformed lines were multipliedin greenhouse, and herbicide tolerance wasevaluated using different concentrations (3, 4, 8 and16 l\/ha) of glyphosate (Helm 48 %p\/v). All herbicidetolerant(HT) lines were field tested to confirmglyphosate tolerance and perform preliminary evaluationsof phenotypic resemblance to parental cultivar.All transformed lines maintained herbicide tolerance,but many showed phenotypic changes and\/or growthaberrations. Ten HT lines, showing close growthresemblance to RA 87-3, were analyzed using ninecompulsory morphologic markers proposed by theInternational Union for the Protection of New Varietiesof Plants (UPOV) and 339 molecular markers.Out of the ten HT lines tested, six showed minormorphologic and genetic variations and were selectedfor field testing over two vegetative crop cycles (plantcane and first ratoon) at two production areas inArgentina. The six field-tested HT lines were found tobe almost indistinguishable when comparing agronomicand industrial characteristics and chemicalcomposition. Stable heritance of the CP4 epsps geneand glyphosate tolerance throughout different clonalgenerations were confirmed by RT-qPCR and Southernblot. Taking into account all results, two out of thesix lines tested were selected for a possible commercialrelease. Our study confirms the utility of genetictransformation as a complementary tool to classicalbreeding procedures and highlights the usefulness ofUPOV traits together with molecular markers for earlyselections of transgenic events that closely resembletheir parental genotype.epsps geneand glyphosate tolerance throughout different clonalgenerations were confirmed by RT-qPCR and Southernblot. Taking into account all results, two out of thesix lines tested were selected for a possible commercialrelease. Our study confirms the utility of genetictransformation as a complementary tool to classicalbreeding procedures and highlights the usefulness ofUPOV traits together with molecular markers for earlyselections of transgenic events that closely resembletheir parental genotype.","palabras_clave":"SACCHARUM HYBRID|GLYPHOSATE|CP4 EPSPS GENE|HERBICIDE TOLERANCE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19716,"idioma_id":4,"titulo":"Association of Cone-Rod Homeobox Transcription Factor Messenger RNA With Pediatric Metastatic Retinoblastoma","resumen":"IMPORTANCE:Disseminated retinoblastoma is usually fatal. Identification of small amounts (minimal dissemination [MD]) of tumor cells in extraocular sites might be a tool for designing appropriate treatments.OBJECTIVE:To test cone-rod homeobox (CRX) transcription factor as a lineage-specific molecular marker for metastatic retinoblastoma and for evaluation of MD.DESIGN, SETTING, AND PARTICIPANTS:In a prospective cohort design study, we evaluated CRX messenger RNA (mRNA) by retrotranscription followed by real-time polymerase chain reaction as a diagnostic test in samples obtained from bone marrow, peripheral blood, and cerebrospinal fluid (CSF) at diagnosis, after induction chemotherapy, and during follow-up. The study was conducted from June 30, 2008, to June 30, 2014. Seventeen retinoblastoma primary tumors, 2 retinoblastoma cell lines, and 47 samples of bone marrow from other cancers (controls) were studied. Seventeen patients with metastatic retinoblastoma (9 at diagnosis, 8 at relapse; age range: 18-41 months) were included.MAIN OUTCOMES AND MEASURES:Detection of CRX mRNA as a marker for metastatic retinoblastoma and MD in bone marrow and CSF and its correlation with clinical findings.RESULTS:Cone-rod homeobox mRNA was expressed in all tumors (relative expression levels range, 8.1&#8201;×&#8201;10-5 to 5.6) and cell lines. In control samples, there was no amplification of CRX; only the housekeeping gene (GAPDH) demonstrated amplification. Bone marrow metastatic cells showed expression of CRX mRNA in all 9 children presenting with metastasis at the diagnosis (relative expression levels, 6.0&#8201;×&#8201;10-5 to 0.67). After induction chemotherapy, no evidence of MD of tumor cells was seen in any of the 8 responding children since only GAPDH showed amplification. In the CSF of children who had a metastatic relapse, CRX mRNA detection was positive in 2 patients in whom no conclusive results were reached by immunocytology for disialoganglioside GD2. Minimal dissemination in the CSF was associated with a clinical relapse in 2 cases. No concomitant MD was evident in the bone marrow in any case.CONCLUSIONS AND RELEVANCE:These data suggest that CRX mRNA is a novel marker for retinoblastoma at extraocular sites. In this study among patients with bone marrow metastasis, there was a quick, complete, and sustained molecular response after induction chemotherapy. In all patients with secondary metastasis, CSF relapse occurred independently from the bone marrow, suggesting a sanctuary site.","palabras_clave":"Retinoblastoma|Metastasis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19717,"idioma_id":4,"titulo":"Curing kinetics of epoxy \/ alkyl phosphonium modified nanoclay composites for high performance applications","resumen":"Alkyl phosphonium salts are novel and unexplored modifiers for polymer based composites which can improve the clays compatibility and dispersion in the polymer matrix. These salts can enhance the thermal stability of the modified clays, which is an indispensable requirement for thermosetting composites curing and processing occurring at high temperatures. In this work, a raw bentonite was ion exchanged with tributyl(hexadecyl) phosphonium bromide and then a novel epoxy\/nanoclay composite was synthesized. The curing kinetics of the nanocomposites was studied. An extensively kinetic study was performed by FT-IR analysis and models accounting for many potential reactions and diffusion restrictions were proposed. A relationship between the H-bonding interactions and the kinetics was found. Also, the effect of the modifier of bentonite was found to affect the reaction yield.","palabras_clave":"Nanocomposites|Clay|Kinetics|FTIR"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19718,"idioma_id":4,"titulo":"Biochemical and molecular mechanisms involved in simultaneous phenol and Cr(VI) removal by Acinetobacter guillouiae SFC 500-1A","resumen":"Abstract Bioremediation has emerged as an environmentalfriendly strategy to deal with environmental pollution. Sincethe majority of polluted sites contain complex mixtures ofinorganic and organic pollutants, it is important to find bacterialstrains that can cope with multiple contaminants. In thiswork, a bacterial strain isolated from tannery sediments wasidentified as Acinetobacter guillouiae SFC 500-1A. Thisstrain was able to simultaneously remove high phenol andCr(VI) concentrations, and the mechanisms involved in suchprocess were evaluated. The phenol biodegradation wascatalized by a phenol-induced catechol 1,2-dioxygenasethrough an ortho-cleavage pathway. Also, NADH-dependentchromate reductase activity was measured in the cytosolicfraction. The ability of this strain to reduce Cr(VI) to Cr(III)was corroborated by detection of Cr(III) in cellular biomassafter the removal process. While phenol did not affect significantlythe chromate reductase activity, Cr(VI) was a majordisruptor of catechol dioxygenase activity. Nevertheless, thisactivity was high even in presence of high Cr(VI) concentrations.Our results suggest the potential application ofA. guillouiae SFC 500-1A for wastewaters treatment, andthe obtained data provide the insights into the removalmechanisms, dynamics, and possible limitations of thebioremediation.","palabras_clave":"ACINETOBACTER|PHENOL|BIOREMEDIATION|CATECHOL DIOXYGENASE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19719,"idioma_id":4,"titulo":"The 'Hidden' Code: Coding and Classifying in Rock Art. The Case of Northwestern Patagonia","resumen":"In spite of its importance for rock art studies, rock art motifs coding andclassification process is not always made explicit. In this discussion of the process ofrock art classification, we consider an exploratory research employing two differentcriteria for the coding of a northwestern Patagonian rock art motifs database. Onecoding makes use of a ?lumping? criterion, and the other uses a ?splitting? criterion.Each of these criteria will be evaluated using cladistic analysis, recording how eachcoding criterion affects results. As a conclusion, and given our results, the use of morethan one coding criterion is suggested when classifying rock art.","palabras_clave":"ARTE RUPESTRE|PATAGONIA|CLASIFICACIÓN|CODIFICACIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19720,"idioma_id":5,"titulo":"Estrategias y acciones en una escuela a la que concurren adolescentes y jóvenes de sectores populares en Caleta Olivia\/Santa Cruz","resumen":"Eneste artículo presentamos estrategias y acciones que se desarrollan en unaescuela secundaria pública emplazada en un barrio popular de la ciudad deCaleta Olivia en la Provincia de Santa Cruz. A esta escuela -de recientefundación- concurren adolescentes y jóvenes que atraviesan múltiples, diversasy duras situaciones sociales. Nos proponemos describir las tareas cotidianas quelos sujetos de la escuela hacen con gran esfuerzo para no sólo sostener laescolaridad de los adolescentes y jóvenes sino, también, ofrecerles horizontesde posibilidad. Retomar estas vivencias que hacen la escuela día a día adquiererelevancia para pensar críticamente cómo esas estrategias y acciones que se desarrollandesde la institución permiten el seguimiento, el acompañamiento y el sostenimientode las trayectorias de los estudiantes en un contexto particular y, a la vez,son parte de las lógicas de las actuales sociedades del gerenciamiento(Grinberg, 2008), en el que los sujetos y las instituciones están arrojados asu propia suerte. ","palabras_clave":"Estrategias|Escuelas secundarias|Jóvenes|Sectores populares"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19721,"idioma_id":4,"titulo":"Trans fatty acids modify nutritional parameters and triacylglycerol metabolism in rats: differential effects at recommended and high-fat levels","resumen":"Introducción: existen escasas evidencias sobre los efectos metabólicos de AGT a niveles recomendados de grasa.Objetivo: investigar los efectos diferenciales de ácidos grasos trans (TFA) sobre parámetros nutricionales, retención de TFA y regulación de triacilglicéridos (TAG) en ratas alimentadas con niveles recomendados o elevados de grasa.Métodos: Ratas macho Wistar fueron alimentadas (30 días) con dietas conteniendo 7% o 20% de grasa suplementadas o no con TFA (C7-C20-TFA7-TFA20).Resultados: TFA7 (vs. C7) incrementó el peso corporal asociado a mayores panículos adiposos y TAG. La hipertriacilgliceridemia fue relacionada a menor actividad LPL muscular, y el incrementado TAG hepático a una elevada expresión génica de SREBP-1c y actividad ACC, y reducida expresión génica de CPT-Ia. Los TFA no potenciaron los elevados pesos corporales, panículos adiposos y TAG inducidos por C20. Aunque la secreción hepática de TAG (TAG-SR) incrementó en TFA20 vs. C20, la similar triacilgliceridemia fue asociada a un compensatorio incremento de actividad LPL en tejido adiposo. La atenuada acumulación hepática de TAG en TFA20 estuvo relacionado a una incrementada TAG-SR y a un menor incremento de la expresión génica de SREBP-1c y SCD1, paralelo a un relativo descenso del índice SCD1 y de la actividad ACC.Discusión y conclusión: los TFA alteran parámetros nutricionales y lipídicos en ratas. Sin embargo, diferentes respuestas sobre los niveles y regulación de los TAG por los TFA fueron observadas entre ratas alimentadas con niveles recomendados y elevados de grasa dietaria. Estas divergencias pueden estar relacionadas a diferentes retenciones de TFA y bioconversión a ácido ruménico.","palabras_clave":"ISOMER RETENTION|TRIACYLGLYCEROL-SECRETION RATE|LIPOPROTEIN LIPASA|LIPID REGULATION|LIPID ACCRETION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19722,"idioma_id":4,"titulo":"Lethal Activity of Individual and Mixed Monoterpenoids of Geranium Essential Oil on Musca domestica","resumen":"Abstract Plant essential oils and its constituent moleculeshave been suggested as an alternative to control insect.The contribution of the constituents to the effect of theoil is determined by the interactions occurring betweenthem. Synergistic interactions would improve the insecticideefficacy of the compounds due to the utilizationof lower doses. We evaluated the insecticidal activity ofgeranium (Geranium maculatum L.) oil and its major constituentsagainst Musca domestica L. and studied the toxic interactionsin artificialmixtures of those constituents in the naturalratio. While synergistic interactions were determined in housefly in this study, these were of low intensity evidencing thatthe effect of each constituent was slightly modified by theother constituents present in the mixtures. The search for synergismbetween components is a strategy to improve the insecticideactivity of natural compounds. The synergism helpsto reduce the environmental and toxicological impact due tothe reduction of the dose of use.","palabras_clave":"Toxci interactions|monoterpenoids|synergism|house fly"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19723,"idioma_id":4,"titulo":"Insecticide resistance in vector Chagas Disease: evolution, mechanisms and management","resumen":"tChagas disease is a chronic parasitic infection restricted to America. The disease is caused by the proto-zoa Trypanosoma cruzi, which is transmitted to human through the feces of infected triatomine insects.Because no treatment is available for the chronic forms of the disease, vector chemical control repre-sents the best way to reduce the incidence of the disease. Chemical control has been based principallyon spraying dwellings with insecticide formulations and led to the reduction of triatomine distributionand consequent interruption of disease transmission in several areas from endemic region. However, inthe last decade it has been repeatedly reported the presence triatomnes, mainly Triatoma infestans, afterspraying with pyrethroid insecticides, which was associated to evolution to insecticide resistance. In thispaper the evolution of insecticide resistance in triatomines is reviewed. The insecticide resistance wasdetected in 1970s in Rhodnius prolixus and 1990s in R. prolixus and T. infestans, but not until the 2000s resis-tance to pyrthroids in T. infestans associated to control failures was described in Argentina and Bolivia. Themain resistance mechanisms (i.e. enhanced metabolism, altered site of action and reduced penetration)were described in the T. infestans resistant to pyrethrods. Different resistant profiles were demonstratedsuggesting independent origin of the different resistant foci of Argentina and Bolivia. The deltamethrinresistance in T. infestans was showed to be controlled by semi-dominant, autosomally inherited factors.Reproductive and developmental costs were also demonstrated for the resistant T. infestans. A discussionabout resistance and tolerance concepts and the persistence of T. infestans in Gran Chaco region are pre-sented. In addition, theoretical concepts related to toxicological, evolutionary and ecological aspects ofinsecticide resistance are discussed in order to understand the particular scenario of pyrethroid resistancein triatomines.","palabras_clave":"Insecticide resistance|Triatominae|Pyrethroids|Chagas disease|Triatoma infestans|Chemical control"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19724,"idioma_id":4,"titulo":"Optimization of ethanol fermentation from discarded carrots using immobilized Saccharomyces cerevisiae","resumen":"Discarded carrots are a valuable source of biomass amenable for valorization. Their use as raw material for ethanol production by fermentation, using yeasts immobilized in Calcium alginate, was proposed. The biocatalyst immobilization method, the existence of internal and external mass transfer limitations, the effect of the initial pH and the reuse of immobilized yeasts were particularlyevaluated. Results indicate that beads made with a 2 % solution of Sodium alginate and a 30 % solution of Saccharomyces cerevisiae were strong enough to allow an efficient nutrient transfer into the matrix and to prevent cell leaking. A stirring rate of 200 rpm was needed to avoid external mass transfer limitations. These beads were used in three successive fermentations. An initial pH of 5.5 reached the best fermentation parameters. Non-enriched, non-sterile carrot must was fermented through immobilized yeasts; and values of ethanol concentration (29.9 g L-1), Yp\/s (0.409 g g-1), and productivity (7.45 g L-1 h-1) were obtained. These values were similar to those registered when free cells were used.","palabras_clave":"BIOETHANOL|CARROT DISCARD|IMMOBILIZATION|CALCIUM ALGINATE BEAD|REUSE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19725,"idioma_id":4,"titulo":"INHERITANCE OF APOSPOROUS APOMIXIS IN INTERSPECIFIC HYBRIDS DERIVED FROM SEXUAL PASPALUM PLICATULUM AND APOMICTIC PASPALUM GUENOARUM","resumen":"Apomictic Paspalum plicatulum and P. guenoarum are promising candidates for forage grass development in tropical regions. From a plant breeding perspective, apomixis provides a unique mechanism for developing superior cultivars and preserving them indefinitely. Therefore, analysis of its inheritance is of great interest in these apomictic species. The objective of this work was to analyze the inheritance and expressivity of apomixis in interspecific families derived from crosses between a sexual colchicine-induced plant of P. plicatulum and an apomictic P. guenoarum plant. One F1, one F2 and three BC populations were created. AFLP markers confirmed the hybrid origin of the F1 descendants. Analysis of the reproductive mode of the F1 by FCSS showed a segregation ratio of 1.6:1 sexual vs. apomictic plants. The same analysis in F2 and BC populations showed that in selfing or crosses involving sexual genotypes all progeny reproduced by sexuality, while BC populations involving apomictic hybrids as pollen donors produced offspring that segregated for the reproductive mode. Apomixis can be transmitted by pollen from P. guenoarum to other species of the Plicatula group, as a simplex (Aaaa) Mendelian dominant factor, and full sexual reproduction requires the homozygous recessive (nulliplex) condition (aaaa) for the apomixis determinant. Results provided here are of interest for breeding apomictic species of Plicatula, and for basic research on the genetic determinants of apomixis. Also, the possibility of creating new apomictic cultivars by traditional breeding methods is presented.","palabras_clave":"PASPALUM|GENETIC BREEDING|APOMIXIS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19726,"idioma_id":5,"titulo":"Cuerpos que importan al campo. La inauguración de María Inés Krimer","resumen":"En los últimos años se advierte en ciertas zonas de la cultura argentina contemporánea un creciente interés en temas, ambientaciones, motivos rurales. En ese marco, se registra también una amplia variedad de firmas de escritoras interesadas en labrar nuevas historias e instalar nuevos modos de representación del cuerpo femenino&nbsp; en ese espacio tradicional y caracterizado por místicas viriles, que cuenta con fuertes cargas simbólico-ideológicas. A la luz de la apertura novedosa sobre la representación de la relación campo\/ cuerpo&nbsp; desde la perspectiva de su protagonista- mujer que trajo la novela El desperdicio (2008) de Matilde Sánchez en la escena literaria del presente, en este trabajo me concentro en los modos de figuración de esa relación espacio rural y cuerpo, y en el tratamiento de un tema de actualidad (el secuestro y tráfico de mujeres) en La inauguración (2011) de la escritora argentina María Inés Krimer. Me interesa en particular proponer una lectura que atienda a los modos&nbsp; de representación de los cuerpos femeninos allí trasplantados y violentados, y a sus formas de&nbsp; circulación en aquel espacio, que se evidencia asfixiante y laberíntico tanto en el encierro propiamente dicho como a la intemperie.&nbsp; (Revista con doble referato e indizada y catalogada en LatindexDirectorio)","palabras_clave":"CUERPO|CAMPO|LA INAUGURACIÓN DE MARIA INES KRIMER|LITERATURA DEL PRESENTE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19727,"idioma_id":4,"titulo":"Labor Exclusion and the Erosion of Citizenship Responsibilities","resumen":"This paper shows that workers who do not receive legally mandated benefits due to employer noncompliance take a negative perspective not only toward the employer as it has been documented but also against the state. They consider that the state did not protect their rights, and hence feel fewer obligations to comply with their duties as citizens. Using a list experiment, as well as householddata from nine Latin American countries, we show that nonregistered workers are less likely to obey the law, pay taxes, and vote compared to registered workers.","palabras_clave":"citizenship responsibilities|labor exclusion"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19728,"idioma_id":4,"titulo":"Theoretical and experimental analysis of the oxidation of CO on Pt catalysts supported on modified TiO2(101)","resumen":"The dynamics of the CO adsorption on Pt nanoparticles deposited on TiO2(101) (pure, N-doped and\/or reduced) have been investigated using UV-visible diffuse reflectance spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy and density functional theory. The results point to that the roles played by N-doping and oxygen vacancies in the systems analyzed enhance the ability of Pt\/TiO2 towards the CO oxidation to CO2 by oxygen atoms of support surface. ","palabras_clave":"CO OXIDATION|Pt\/N-TiO2 (101)|O VACANCIES|DFT|DRIFTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19729,"idioma_id":5,"titulo":"Disponibilidad de recursos líticos y movilidad durante el Holoceno tardío en el centro-oeste de la provincia de Santa Cruz","resumen":"La base regional de recursos líticos del centro-oeste de Santa Cruz se caracteriza por una alta frecuencia, distribución y variedad de materias primas de excelente calidad para la talla, que incluye no sólo obsidiana negra sino también basaltos, rocas silíceas y limolita. Es así que en este marco donde el aprovisionamiento de materia prima no constituye un problema a resolver, buscamos evaluar cómo la tecnología responde al modo en que los grupos cazadores-recolectores organizan su utilización del paisaje regional y a las estrategias de movilidad desarrolladas. En este trabajo realizamos una síntesis de la localización y propiedades de las principales materias primas de la región, en la cual se vienen efectuando relevamientos sistemáticos  desde la década de 1980. Aquí, buscamos principalmente delinear  las características de la utilización de estos recursos durante el Holoceno tardío. De manera independiente a las diferentes distancias entre las fuentes de aprovisionamiento y los espacios de uso de las materias primas, se interpreta que los patrones de movilidad de los grupos habrían incidido en la accesibilidad a todas las rocas aquí presentadas.","palabras_clave":"PATAGONIA|RECURSOS LÍTICOS|APROVISIONAMIENTO|TECNOLOGÍA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19730,"idioma_id":5,"titulo":"Kau. Los toldos tehuelches en los dibujos, grabados y fotografías de viajeros por la Patagonia (Argentina y Chile)","resumen":"En este trabajo analizaremos un corpus de veintidós dibujos, grabados y fotografías de toldos  tehuelches producidos por diversos viajeros que recorrieron la Patagonia desde comienzos del   siglo XIX hasta comienzos del siglo XX, con el objetivo de rastrear las semejanzas y diferencias en las representaciones de dichas estructuras de habitación generadas mediante estos diferentes sistemas de representación. Para ello, centramos el estudio en la comparación de la estructura del toldo, su tamaño, apertura, orientación, paisaje circundante, cultura material, personas y fauna asociada. Los resultados del análisis muestran la existencia de sesgos en cada sistema de representación, a pesar de los cuales las imágenes muestran una continuidad en las formas de documentar visualmente una parte de la realidad pasada ; que permite rescatar elementos relativos a la agencia de los sujetos productores y usuarios de los toldos y a la pregnancia de los objetos representados, que a su vez se transmite a las imágenes que los documentan.","palabras_clave":"Patagonia|registros visuales|toldos|materialidad"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19731,"idioma_id":4,"titulo":"Simplified reaction kinetics, models and experiments for glyphosate degradation in water by the UV\/H2O2 process","resumen":"A simplified mathematical model to describe the oxidative degradation of glyphosate employing hydrogen peroxide and UV radiation was developed based on a sequence of predominant reactions. The kinetics obtained include all the required significant variables. Consequently, not only were concentration dependencies examined but also the influence of a detailed spatial description of the radiation field was included as part of the modeling. The kinetic parameters were obtained by comparing the simulation concentrations obtained with the model with the experimental values gathered in the laboratory reactor, employing a multiparameter non-linear regression analysis. In addition, the potential of the H2O2\/UV process for treating water polluted with a commercial formulation, which was the glyphosate monoisopropylamine salt plus some additives, was studied. The glyphosate and TOC (total organic carbon) conversions reached were close to 80% and 70% respectively at 12 h (0.66 h actual exposure to radiation). It has been shown that a simple reaction scheme for the degradation of glyphosate acid and glyphosate isopropylamine salt from a commercial formulation can represent with good accuracy the performance of both reacting systems. In addition, the degradation procedure allowed a clear reduction of the toxicity of the glyphosate in the formulation over Vibrio fischeri at the end of the experiments. For this reason, reaching complete mineralization might not be necessary.","palabras_clave":"vibrio|fischeri|glyphosate|degradation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19732,"idioma_id":4,"titulo":"Infectious bursal disease virus uptake involves macropinocytosis and trafficking to early endosomes in a Rab5-dependent manner","resumen":"Infectious bursal disease virus (IBDV) internalization is sparsely known in terms of molecular components of the pathway involved. To describe the cell biological features of IBDV endocytosis, we employed perturbants of endocytic pathways such as pharmacological inhibitors and overexpression of dominant-negative mutants. Internalization analysis was performed quantifying infected cells by immunofluorescence and Western blot detection of the viral protein VP3 at 12&#8201;h post-infection reinforced by the analysis of the capsid protein VP2 localization after virus uptake at 1&#8201;h post-infection. We compared IBDV infection to the internalization of well-established ligands with defined endocytic pathways: transferrin, cholera-toxin subunit B and dextran. To describe virus endocytosis at the morphological level, we performed ultrastructural studies of viral internalization kinetics in control and actin dynamics-blocked cells. Our results indicate that IBDV endocytic internalization was clathrin- and dynamin-independent, and that IBDV uses macropinocytosis as the primary entry mechanism. After uptake, virus traffics to early endosomes and requires exposure to the low endocytic pH as well as a functional endocytic pathway to complete its replication cycle. Moreover, our results indicate that the GTPase Rab5 is crucial for IBDV entry supporting the participation of the early endosomal pathway in IBDV internalization and infection of susceptible cells.    Nota: la publicación fue aceptada el día 16 de Diciembre del 2014. Incluyo aquí la carta por parte de la editora de la revista en la que nos comunica que solo eran necesarios unos cambios mínimos de redacción.    From:jacomine.krijnse@bioquant.uni-heidelberg.de  To:ldelgui@fcm.uncu.edu.ar  CC:  Subject:Cellular Microbiology - CMI-14-0223.R1  Body:Dear Dr. Delgui,     Your manuscript, 'Infectious Bursal Disease Virus uptake Involves Macropinocytosis and Trafficking to Early Endosomes in a Rab5-dependent Manner', has been reviewed by the same two referees. Their reports are included below.     As you will see both reviewers are very satisfied with the changes made. However, the second reviewer recommends a minor text change related to the requirement of cholesterol.     Please resubmit your revised manuscript to me at ManuscriptCentral, https:\/\/mc.manuscriptcentral.com\/cell-micro. Please include a letter stating how you have addressed this minor comment upon which I will accept the manuscript in due course.     To help the editor and reviewers, please upload two versions of your manuscript text in Word format, one ´clean´ version and one with the changes made highlighted in yellow.     To maintain current scientific reviews, revisions of manuscripts should be resubmitted within 3 months of the editor´s decision. Additional time for resubmission required to conduct specific experimental protocols may be requested in advance.     I look forward to receiving your revised manuscript.     Best regards,   Jacomine Krijnse Locker     Referees comments:     Referee: 1     Comments to the Author   (There are no comments.)     Referee: 3     Comments to the Author   The addition of controls for the various internalization assays, and the inclusion of GTPase experiments, additional compounds and dextran uptake assays have served to greatly improve the manuscript. The role of macropinocytosis in entry of IBD is convincingly demonstrated.     Minor comment: The authors imply that due to the effect seen with cholesterol depleting drugs that perhaps Caveolea is involved in entry. I do not understand this link as dynamin depletion (which is required for caveolea endocytosis) has no impact on infection and cholesterol is required for macropinocytosis (Grimmer, S., van Deurs, B. & Sandvig, K. Membrane ruffling and macropinocytosis in A431 cells require cholesterol. J. Cell Sci. 115, 2953?2962 (2002). Why do the authors not think the cholesterol requirement is more in support of their data on macropinocytosis?  Date Sent:16-Dec-2014","palabras_clave":"BIRNAVIRIDAE|INTERNALIZATION|MACROPINOCYTOSIS|RAB5"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19733,"idioma_id":4,"titulo":"(-)-Epicatechin reduces blood pressure increase in high fructose-fed rats: effects on the determinants of nitric oxide bioavailability","resumen":"This work investigated the blood pressure (BP)-lowering effect of the flavanol (-)-epicatechin in a model of metabolic syndrome. Rats were fed a regular chow diet without (Control) or with 10% (w\/v) fructose in the drinking water (high fructose, HF) for 8 weeks. A subgroup of the HF-fed rats was supplemented with (-)-epicatechin 20 mg\/kg body weight (HF-EC). Dietary (-)-epicatechin reverted the increase in BP caused by the fructose treatment. In aorta, superoxide anion production and the expression of the NADPH oxidase (NOX) subunits p47(phox) and p22(phox) were enhanced in the HF-fed rats. The increase was prevented by (-)-epicatechin. Similar profile was observed for NOX4 expression. The activity of aorta nitric oxide synthase (NOS) was increased in the HF group and was even higher in the HF-EC rats. These effects were paralleled by increased endothelial NOS phosphorylation at the activation site Ser1177. Among the more relevant mitogen-activated protein kinase pathways in vascular tissue, c-Jun-N-terminal kinase was shown to be activated in the aorta of the HF-fed rats, and (-)-epicatechin supplementation mitigated this activation. Thus, the results suggest that dietary (-)-epicatechin supplementation prevented hypertension in HF-fed rats, decreasing superoxide anion production and elevating NOS activity, favoring an increase in NO bioavailability.","palabras_clave":"FLAVONOIDS|FRUCTOSE|HYPERTENSION|METABOLIC SYNDROME"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19734,"idioma_id":4,"titulo":"SUPERCRITICAL CARBON DIOXIDE FRACTIONATION OF PEPPERMINT OIL WITH LOW MENTHOL CONTENT - EXPERIMENTAL STUDY AND SIMULATION ANALYSIS FOR THE RECOVERY OF PIPERITENONE","resumen":"Low-menthol or dementholized oils can be regarded as potential sources of biocidal compounds, particularly monoterpenic ketones such as menthone, piperitenone, pulegone and carvone. In this work, the recovery of piperitenone from peppermint oil by supercritical carbon dioxide fractionation is studied. Separation selectivity and gas loading measurements were performed in a semicontinuous high-pressure apparatus in order to evaluate the effect of temperature and solvent density on these properties. Semicontinuous fractionation was also carried out at a fixed temperature (313K) and pressure (85 bar), collecting and analyzing extract samples until a purified pipperitenone raffinate was obtained. The phase behavior of the system was modeled and predicted with the group contribution equation of state (GC-EoS). Good agreement with the experimental results was obtained. Finally, a continuous countercurrent multistage fractionation process was simulated, based on the GC-EoS model. The effect of operation temperature and pressure, solvent-to-feed ratio and reflux ratio was studied for different purity and recovery requirements and oil feed compositions.","palabras_clave":"peppermint oil|supercritical fluid fractionation|GC-EoS|countercurrent fractionation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19735,"idioma_id":4,"titulo":"Nucleophilic Substitution in Ionizable Fischer Thiocarbene Complexes: Steric Effect of the Alkyl Substituent on the Heteroatom","resumen":"ver trabajo","palabras_clave":"reactivity|Fischer Carbenes|steric effect|nucleophilic substitution"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19736,"idioma_id":4,"titulo":"Synthesis of Crosslinkable Micelles from Diblock Amphiphilic Copolymers Based on Vinylbenzyl Thymine and Vinylbenzyl Triethylammonium Chloride","resumen":" Polymeric micelles (PMs) composed of self-assembledamphiphilic block copolymers were synthesized from vinylbenzyl thymine (VBT)and vinylbenzyl triethylammonium chloride (VBA) exhibiting improved physicalstability. Three diblock copolymers of different chemical compositions andsimilar molecular weights (polydispersities below 1.5) were obtained viaNitroxide Mediated Radical Polymerization. Critical Micelle Concentration (CMC)was determined by dye micellization method, the shift of the absorption peak ofthe anionic Eosin Y (EY) due to the interactions with non-assembled chains andauto-assembled copolymers was followed. Polymeric systems exhibited goodstability revealing that a higher proportion of cationic monomers in thediblock reduces the CMC. Furthermore, after the core of PMs wasphotocrosslinked by UV irradiation, the CMC decreases notably. Kinetic releasestudies using EY dye as probe demonstrated that both, higher VBA ratios in thepolymer and higher UV-irradiation, slow down the dye release.","palabras_clave":"biomimetic|copolymers|drug delivery systems|stimuli-sensitive polymers"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19737,"idioma_id":4,"titulo":"Sesquiterpene lactones from Ambrosia spp.  are active against a murine lymphoma cell line by inducing apoptosis and cell cycle arrest.","resumen":"Sesquiterpene lactones (STLs) are natural terpenoid compounds. They have been recognized as antitumor agents. The purpose of this investigation was to explore the antiproliferative effects of psilostachyin, psilostachyin C, peruvin and cumanin on the murine lymphoma cell line BW5147. Cells were treated with the STLs at different concentrations. Tritiated thymidine uptake was employed to determine cell proliferation. MTT assay was used to analyze cell viability. Flow cytometry assay with annexin V-FITC and propidium iodide was employed to evaluate cell death. Reactive oxygen species (ROS), mitochondrial membrane potential and cell cycle analysis were also evaluated by flow cytometry. Antioxidant enzymesactivities were determined spectrophotometrically by kinetic assays. Results showed that these STLs inhibited cell proliferation in a concentration-dependent manner by exerting cytotoxicity through apoptosis. Psilostachyin C was the most active and the less toxic compound. This STL induced apoptosis with an impairment in mitochondrial membrane potential. Psilostachyin C was able to induce ROS generation, related to a modulation of the antioxidant enzymes activity. In addition, it induced cell cycle arrest in S phase. In conclusion, psilostachyin C was found to be active against lymphoma cells exerting both cytostatic and cytotoxic effects. These findings may provide a novel approach for lymphoma treatment.","palabras_clave":"SESQUITERPENE LACTONES|CYTOTOXICITY|T-CELL LYMPHOMA|OXIDATIVE STRESS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19738,"idioma_id":4,"titulo":"Extended Best Polynomial Approximation Operator In Orlicz Spaces","resumen":"We recently dealt with the best polynomial approximationoperator in an Orlicz Space L and its extension to L&#966;, where &#966; is thederivative of the function .In this paper, we study weak and strong type inequalities for maximaloperators related to the extended best polynomial approximation op-erator from L to L&#966;. Then, applying these results, we obtain normconvergence of the coefficients of the extended best polynomial approx-imation operator.","palabras_clave":"ORLICZ SPACES|BEST POLYNOMIAL PHI-APPROXIMATION OPERATORS|EXTENDED BEST POLYNOMIAL APPROXIMATION FROM L^PHI TO L^varphi"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19739,"idioma_id":4,"titulo":"Tooth microstructure and feeding biology of the brittle star Ophioplocus januarii (Echinodermata: Ophiuroidea) from northern Patagonia, Argentina","resumen":"Ophioplocus januarii is a common brittle star along the Argentinian and Brazilian coasts occurring on both, soft and hard substrates. Based on stomach contents and tooth microstructure analysis and together with field observations, the feeding habit of this species is described. Opposed to previous suggestions, O. januarii appears to be a microphagous species feeding on macroalgal fragments (found in 60.0% of the analyzed stomachs with content), plant debris (28.0%), animal cuticle structures (13.0%), and unidentifiable material (30.7%). Less frequent items found were foraminiferans, ostracods, an amphipod, a juvenile bivalve, and other crustaceans. Small portions of the unidentifiable material were investigated under at the light microscope and with a scanning electronic microscope and revealed digested material, diatoms and small crustacean appendices. Thus, O. januarii is an omnivorous species, feeding mainly on algae, complemented opportunistically with other items. Suspension feeding was observed in the field. Analysis of the microstructure of the tooth stereom revealed an intermediate fenestrated arrangement which is to be positioned between the two so far described types of uniform and compound teeth. Hereby the former have been typically found in macrophagous species whereas the latter generally correspond to microphagous ophiuroids. Here, we propose a new kind of intermediate arrangement in the dental stereo structure of ophiuroids.","palabras_clave":"BRITTLE STAR|MICROSTRUCTURE|STOMACH CONTENTS|OPHIOLEPIDIDAE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19740,"idioma_id":4,"titulo":"Ecotoxicological assessment of soil microbial community tolerance to glyphosate","resumen":"Glyphosate is the most used herbicide worldwide.  While contrasting results have been observed related with its impact on soil  microbial communities, more studies are necessary to elucidate the potential effects  of the herbicide. Differences in tolerance detected by Pollution Induced  Community Tolerance (PICT) approach could reflect these effects. The objective  of the present study was to assess the tolerance to glyphosate (the active  ingredient and a commercial formulation) of contrasting soils with (H) and  without (NH) history of exposure. The hypothesis of a higher tolerance in H  soils due to a sustained selection pressure on community structure was tested  through the PICT approach. Results indicated that tolerance to glyphosate is  not consistent with previous history of exposure to the herbicide. Studies of  community structure based on Denaturant Gradient Gel Electrophoresis (DGGE) and  Quantitative Real Time PCR (Q-PCR) showed that composition and abundance of  bacteria, respectively, did not differ significantly between H and NH soils, in  accordance with PICT results. Consequently, the lack of significant differences  in tolerance in most cases could be partially explained by a similar community  structure. This is, to our knowledge, the first report of PICT approach with  glyphosate examining tolerance at soil microbial community level. Future culture-independent  analysis focused on specific groups of microorganisms instead of whole  microbial communities could be important to provide stronger evidences  supporting our results and conclusions.  ","palabras_clave":"GLYPHOSATE|SOIL MICROBIAL COMMUNITY|PICT ASSAY|DGGE PROFILES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19742,"idioma_id":4,"titulo":"Corrosion study of MgO-C bricks in contact with a steelmaking slag","resumen":"The MgO-C bricks are extensively used as lining work on different steel containers. Due to the high temperatures of the process,these refractories are subjected to severe wear and corrosion processes, principally in the area of contact with the slag. Theseslags have variable contents of CaO, SiO2, Al2O3, MgO and FeO, varying in composition according to the process stage. In thispaper, cup tests were performed at 1650 °C during 2 hours in air, using three kinds of commercial MgO-C bricks. They were putin contact with a high basicity slag. The corrosion degree and decarburization level sufferered by the refractories were analyzedand compared. Microstructural observations were performed in order to postulate the probable corrosion mechanisms acting oneach material.","palabras_clave":"MgO-C|SLAGS|CORROSION|MICROSTRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19743,"idioma_id":4,"titulo":"Isolation and molecular characterization of a new Neospora caninum isolate from cattle in Argentina","resumen":"Neospora caninum is one of the most important causes of bovine abortion, but isolation of live parasites from infected tissue is difficult. The aims of the present study were to obtain new isolates of N. caninum from congenitally infected asymptomatic newborn cattle in Argentina and to perform characterization by multilocus-microsatellite analysis. Five clinically normal born calves, with demonstrable N. caninum antibodies in precolostrum serum by indirect fluorescent antibody test, were euthanized and their brain  samples were processed for histopathological, immunohistochemical, polymerase chain reaction (PCR) analysis, and for bioassay in &#947;-interferon knockout (GKO) mice. Although N. caninum DNA was detected in brain from all the calves by PCR, viable N. caninum was isolated in GKO mice from only one calf. Neospora  caninum tachyzoites of this Argentinean isolate, designated NC-Argentina LP1, were propagated in VERO cell cultures seeded with tachyzoites from the infected GKO mice tissues. Multilocus-microsatellite typing on DNA derived from cell cultured tachyzoites revealed a unique genetic pattern, different from reported  isolates. This is the first bovine isolation and genetic characterization of N. caninum in Argentina.","palabras_clave":"Neospora caninum|Isolate|Dairy asymptomatic calf|Multilocus-microsatellite analysis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19744,"idioma_id":4,"titulo":"Globe artichoke cultivation in Argentina","resumen":"Horticulture in Argentina is an intensive  activity that covers a smaller area than  other agricultural activities, but involves a  greater return per hectare. Agriculture occupies  around 30% of Argentina?s total area of  approximately 270 million hectares. Whilst  only 2% of this area involves horticultural  practices, it represents up to 11% of the  value of Argentinian agricultural products.  The horticulture area has expanded to  approximately 500,000 hectares, but varies  from year to year since most crops are annuals.  Garlic, sweet potato, onion, lettuce,potato, pepper, beans, tomato, carrot, and squash comprise 85% of the total horticultural  production value.","palabras_clave":"Cynara cardunculus|Horticultural crop"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19745,"idioma_id":5,"titulo":"La comunidad de parásitos gastrointestinales de guanacos silvestres (Lama guanicoe) de la Reserva provincial La Payunia, Mendoza, Argentina","resumen":"RESUMEN. Los vertebrados silvestres albergan comunidades parasitarias compuestas por varias especies, perola estructura natural de estas comunidades se está viendo afectada en la actualidad por la fragmentación dehábitat e introducción de especies exóticas. El objetivo de este trabajo fue identificar a las especies de parásitosgastrointestinales presentes en la población migratoria de guanacos silvestres de la reserva provincial La Payunia (Mendoza), mediante la identificación de las formas evolutivas presentes en la materia fecal. Se analizaron las heces de 756 individuos, colectadas entre los años 2009 y 2012. La comunidad parasitaria gastrointestinal de esta población de guanacos estuvo compuesta por al menos 11 especies. Los parásitos pertenecieron a 5 especies de nematodes: 2 de Nematodirus, 1 de Trichuris, 1 de Capillaria y 1 de Strongyloides; 1 especie de cestode correspondient a Moniezia benedeni, y 5 especies de protozoos del género Eimeria (E. lamae, E. alpacae, E. punoensis, E. macusaniensis y E. ivitaensis). Nematodirus spp., Strongyloides sp. y Moniezia benedeni son parásitos propios de rumiantes domésticos y su presencia refleja la susceptibilidad del guanaco, por lo que se recomienda realizar monitoreos parasitológicos periódicos, a fin de poder anticiparse ante incrementos importantes en este tipo de parasitismo en los guanacos silvestres","palabras_clave":"BOVINO|GUANACO|LAMA GUANICOE|OVINO"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19746,"idioma_id":5,"titulo":"La política bajo sospecha. Regularidades y reformulaciones de la vigilancia política en Argentina: la policía de Santiago del Estero","resumen":"ese al cambio de régimen político y la recuperación del Estado de   Derecho permanecieron organismos de espionaje político-ideológico en el   ámbito de las fuerzas policiales argentinas. A partir del caso de un   organismo de inteligencia policial de una provincia del norte argentino,   indagamos en las regularidades y reformulaciones en las lógicas de   clasificación y modalidades de intervención policial empleadas para la   gestión del orden político en diferentes momentos   político-institucionales que atravesó el país en la segunda mitad del   siglo XX. El análisis de informes de inteligencia pertenecientes al   Departamento de Informaciones Policiales de Santiago del Estero, activo   desde la década del 50 hasta el año 2004, aportó elementos para poner en   cuestión las miradas dicotómicas sobre el pasado reciente argentino que   oponen autoritarismo-democracia, violencia-política y fuerzas de   seguridad-sociedad civil. Los archivos de la represión son la expresión   material de la institucionalización, más allá de las fronteras entre   regímenes políticos, de una lógica estatal que encuentra en el control   político-ideológico una herramienta de preservación del orden   establecido.","palabras_clave":"Vigilancia|Seguridad Estatal|Policía|Violencia|Politica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19747,"idioma_id":4,"titulo":"Azospirillum Growth Promotion Is Related to Changes in Ferulate and Dehydrodiferulate Contents in Cell Wall of Inoculated Cucumber Seedlings Hypocotyls","resumen":"Azospirillum brasilense is a well known plant growth-promoting rhizobacterium. Plant cell growth  is constrained by the primary cell wall (CW) which contains polysaccharide-bound hydroxycinammic  acids (HCAs). They derive from phenylpropanoid metabolism, which first step is the reaction  catalyzed by phenylalanine ammonia-lyase (PAL; EC 4.3.1.24). Also CW peroxidases (FAPOD; EC  1.11.1.7) play a key role in the stiffening of the CW, and in the cessation of cell elongation. Knowledge  of the biochemical effects the bacteria could elicit into plant CW and how these responses  could change the hypocotyl physiology still remains scarce. The objective of this work was to unravel  the effects of A. brasilense Sp245 inoculation on HCAs of the primary CW in apical and basal  segments of cucumber seedlings hypocotyls. Azospirillum inoculation increased hypocotyls? length.  Trans-ferulate and p-coumarate were the major HCAs. Dimmers were detected only in the basal  region of 13- and 15-d-old hypocotyls. The ratio t-ferulate\/dimmer (an inverse index of CW crosslinking)  was five times higher in inoculated seedlings. Enzyme activities determined were not directly  involved in HCAs content changes. It was previously reported that the CW was a target for A.  brasilense growth promotion. This work corroborates that the phenolics, FA, DFA, and p-coumarate  bound to the CW are also involved in Azospirillum plant growth promoting strategies.","palabras_clave":"Azospirillum|Plant Growth Promotion|Plant Cell Wall|Hydroxycinammic Acids"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19748,"idioma_id":5,"titulo":"La inclusión de la cuestión social en la perspectiva de género: notas para re-escribir ?Campo Algodonero?","resumen":"El caso Campo Algodonero contra México trata sobre la desaparición y muerte de tres mujeres jóvenes en un contexto de discriminación sistemática. Sostenemos que la Corte IDH se destaca en esta decisión por la aplicación de la concepción de desigualdad estructural para analizar la situación en la que se encontraban las mujeres y en la que ocurrieron las desapariciones y asesinatos; y por aplicar una perspectiva de género. Sin embargo, el abordaje es insuficiente. El énfasis puesto en una causal de la desigualdad estructural ? la cultural ?opaca, otras causas como la económica-social, presentes en el contexto del caso pero ausente en la argumentación relevante de la Corte IDH. Nuestra hipótesis de trabajo sostiene que: Campo Algodonero es considerado un leading case en materia de género y de desigualdad estructural en la jurisprudencia de la Corte IDH. Si bien aceptamos este presupuesto, sostenemos que el Tribunal realiza un abordaje parcial del contexto del caso, puesto que desatiende los siguientes factores: que las mujeres desaparecidas son trabajadoras, jóvenes, por lo general migrantes y de escasos recursos económicos, sometidas a condiciones de (o cercanas a la) explotación laboral, y con falta de acceso suficiente a los servicios indispensables que posibilitan el ejercicio de los derechos sociales.Estos factores hacen a la violencia contra las mujeres en el caso. La  consideración de la cuestión socioeconómica hubiese repercutido en a) el planteo del problema normativo, en b) la extensión de la argumentación en la justificación de la sentencia y en c) las medidas reparatorias. A los efectos de este artículo nos detenemos entonces en la reconstrucción delcontexto.Para sostener nuestra hipótesis retomamos la metodología de análisis de estereotipos contra las mujeres que la propia Corte IDH aplica en el fallo. Sin embargo, marcamos su aplicación parcial desde una concepción de igualdad multidimensional. Estas notas sirven para dos propósitos. Por un lado, enfatizar una metodología que combina identificación de estereotipos y examen de igualdad. Por el otro lado, sirve para bosquejar notas críticas para re-escribir una sentencia sobre género; para visibilizar lo que quedó opacado: la cuestiónsocial desde una perspectiva de género. A los efectos del desarrollo de nuestro trabajo, primero realizaremos un breve mapeo del caso Campo Algodonero, los puntos fuertes en la argumentación (apartado II). Esto nos permitirá identificar luego lo que a nuestro entender quedó olvidado. Transitaremos un análisis contextual más comprensivo de los estereotipos que atraviesan el caso para demostrar la insuficiencia del análisis de la Corte, que basó las causales de la desigualdad estructural exclusivamente en factores culturales dejando a un lado los factores referidos a la estructura de producción que atraviesa las formas de acceso al empleo y su relación con la desaparición de las mujeres (luego asesinadas) en Ciudad de Juárez: esto es, mujeres, jóvenes, pobres, empleadas de maquilas, empleadas domésticas, estudiantes de escuelas secundarias, migrantes (apartado III). En este sentido afirmamos que la sentencia olvidó la desigualdad de género causada por falta de redistribución.","palabras_clave":"Desigualdad estructural|Redistribución\/reconocimiento|Estereotipos de género|Corte Interamericana de Derechos Humanos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19750,"idioma_id":4,"titulo":"Prenatal ethanol exposure alters ethanol-induced fos inmunoreactivity and dopaminergic activity in the mesocorticolimbic pathway of the adolescent brain","resumen":"Prenatal ethanol exposure (PEE) promotes alcohol intake during adolescence, as shown in clinical and pre-clinical animal models. The mechanisms underlying this effect of prenatal ethanol exposure on postnatal ethanol intake remain, however, mostly unknown. Few studies assessed the effects of moderate doses of prenatal ethanol on spontaneous and ethanol induced brain activity on adolescence. This study measured, in adolescent (female) Wistar rats prenatally exposed to ethanol (0.0 or 2.0 g\/kg\/day, gestational days 17-20) or non-manipulated (NM group) throughout pregnancy, baseline and ethanol-induced cathecolaminergic activity (i.e., colocalization of c-Fos and tyrosine hydroxylase) in ventral tegmental area (VTA), and baseline and ethanol-induced Fos inmunoreactivity (ir) in nucleus accumbens shell and core (AcbSh and AcbC, respectively) and prelimbic (PrL) and infralimbic (IL) prefrontal cortex. The rats were challenged with ethanol (dose: 0.0, 1.25, 2.5 or 3.25 g\/kg, i.p.) at postnatal day 37. Rats exposed to vehicle prenatally (VE group) exhibited reduced baseline dopaminergic tone in VTA; an effect that was inhibited by prenatal ethanol exposure (PEE group). Dopaminergic activity in VTA after the postnatal ethanol challenge was greater in PEE than in VE or NM animals. Ethanol-induced Fos-ir at AcbSh was found after 1.25 g\/kg and 2.5 g\/kg ethanol, in VE and PEE rats, respectively. PEE did not alter ethanol-induced Fos-ir at IL but reduced ethanol-induced Fos-ir at PrL. These results suggest that prenatal ethanol exposure heightens dopaminergic activity in the VTA and alters the response of the mesocorticolimbic pathway to postnatal ethanol exposure. These effects may underlie the enhanced vulnerability to develop alcohol use disorders of adolescents with a history of in-utero ethanol exposure.","palabras_clave":"adolescent|rat|prenatal ethanol|dopamine| mesocorticolimbic pathway|Fos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19751,"idioma_id":4,"titulo":"Assessing the genetic diversity of Panicum coloratum var. makarikariense using agro-morphological traits and microsatellite-based markers","resumen":"Panicum coloratum var. makarikariense is a perennial C4 grass native to South Africa withrelatively good forage production under limited-resource conditions. Geneticcharacterisation and breeding efforts have been scant, thus limiting its use incattle raising systems. The goal of the present study was to assess the geneticdiversity of a collection of P. coloratum var. makarikariense using agro-morphological traitsand molecular markers, in comparison with one accession of var. coloratum and one population of Panicum bergii. Agro-morphological variabilitybetween and within accessions of var. makarikariense in a common garden setting wasobserved, showing that there is still opportunity for selection. Someaccessions performed better than the commercialised material in relation topotential forage production. A total of 117 ISSR bands and 48 SSR allelesallowed the detection of genetic variability between and within accessions. Thepresence of accession-specific bands suggested distinctness and limited geneflow. The genetic variability encountered in the commercialised materialsuggested that it is a stabilised population which has not undergone a strongselection process. Low correlation between agro-morphologic and molecularvariability was observed indicating that both approaches provide complementaryinformation. Both morphological and molecular markers reveal geneticdifferentiation between varieties and species. This study provides a set of newSSR markers available for diversity assessment and valuable information that canbe applied directly in collectionmanagement for breeding and conservationprogrammes.","palabras_clave":"C4 FORAGE GRASS|INTER-SIMPLE SEQUENCE REPEATS|PASTURE GERMPLASM|SIMPLE SEQUENCE REPEATS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19752,"idioma_id":4,"titulo":"Raw material circulation at broad scales in southern Patagonia (Argentina): The cases of the Chico and Santa Cruz River basins","resumen":"The purpose of this paper is to begin to understand human mobility through rock transport at different times in two areas with different environmental characteristics: the Southern Deseado Massif and the basaltic canyons north of the Santa Cruz River. We focus on obsidian, which has a clear geochemical  signature and an uneven distribution. Additionally, we use macroscopic information on siliceous rocks, which at present have only been identified in northern areas, although they may also be recovered randomly and in low frequencies in southern ones.  During the initial peopling of the Southern Deseado Massif (ca. 10,800 BP), inhabitants were transporting  black obsidian as well as translucent chalcedony, probably as part of the individual gear. During  the Late Holocene, the number of obsidian artifacts decreased in the Southern Deseado Massif, related to a better knowledge of the high-quality local lithic resources and\/or to the existence of higher population densities. Obsidian artifacts are more abundant in the northern Santa Cruz River basin than in the southern Deseado Massif, suggesting the existence of a relationship with areas located to the northwest, close to the obsidian source, as other lines of evidence suggest. In addition, the presence in the basalticcanyons of artifacts made from high-quality siliceous rocks, more abundant and predictable in northern areas, could also be the result of human movements following a north-south direction.","palabras_clave":"SOUTHERN DESEADO MASSIF|SANTA CRUZ RIVER|HUNTER-GATHERERS|CIRCULATION|OBSIDIAN|SILICEOUS ROCKS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19753,"idioma_id":5,"titulo":"Materias primas líticas y su utilización en las cuencas de los ríos Chico y Santa Cruz (provincia de Santa Cruz, Patagonia argentina)","resumen":"En este trabajo se sintetizan y actualizan los resultados de los relevamientos de materias primas líticas realizados en el extremo sur del Macizo del Deseado, el curso medio del río Chico y en diferentes sectores de la cuenca del río Santa Cruz. Se presentan las variables registradas, así como las razones de las modificaciones introducidas en la metodología de su relevamiento a través del tiempo. Los resultados se integraron en una base de datos que posee un correlato de muestras de mano, identificadas en casos seleccionados mediante cortes delgados. Se hicieron análisis geoquímicos sobre algunas muestras. La información obtenida da cuenta no sólo de las características macroscópicas de las materias primas, sino también de su forma de presentación, dispersión en el espacio y visibilidad. Estos datos se utilizan para evaluar los cambios en el registro arqueológico y sus implicaciones en relación con el comportamiento humano.","palabras_clave":"CAZADORES-RECOLECTORES|MATERIAS PRIMAS LÍTICAS|SUR MACIZO DESEADO|RÍO SANTA CRUZ"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19754,"idioma_id":4,"titulo":"Ancient proteins resolve the evolutionary history of Darwin?s South American ungulates","resumen":"No large group of recently extinct placental mammals remains as  evolutionarily cryptic as the approximately 280 genera grouped as  ?South American native ungulates?. To Charles Darwin1,2, who first  collected their remains, they includedperhaps the ?strangest animal[s]  ever discovered?. Today, much like 180 years ago, it is no clearer  whether they had one origin or several, arose before or after the  Cretaceous\/Palaeogene transition 66.2 million years ago3, or are  more likely to belong with the elephants and sirenians of superorder  Afrotheria than with the euungulates (cattle, horses, and allies) of  superorder Laurasiatheria4?6.Morphology-based analyses have proved  unconvincing because convergences are pervasive among unrelated  ungulate-like placentals. Approaches using ancient DNA have also  been unsuccessful, probably because of rapid DNA degradation  in semitropical and temperate deposits. Here we apply proteomic  analysis to screen bone samples of the Late Quaternary South  American native ungulate taxa Toxodon (Notoungulata) and  Macrauchenia (Litopterna) for phylogenetically informative protein  sequences. For each ungulate, we obtain approximately 90% direct  sequence coverage of type I collagena1- anda2-chains, representing  approximately 900 of 1,140 amino-acid residues for each subunit.A  phylogeny is estimated from an alignment of these fossil sequences  with collagen (I) gene transcripts from availablemammalian genomes  or massspectrometrically derived sequence data obtained for this study.  The resulting consensus tree agrees well with recent higher-level  mammalian phylogenies7?9. Toxodon and Macrauchenia form a  monophyletic group whose sister taxon is not Afrotheria or any  of its constituent clades as recently claimed5,6, but instead crown  Perissodactyla (horses, tapirs, and rhinoceroses). These results are  consistent with the origin of at least some South American native  ungulates4,6 from ?condylarths?, a paraphyletic assembly of archaic  placentals. With ongoing improvements in instrumentation and  analytical procedures, proteomics may produce a revolution in  systematics such as that achieved by genomics, butwith the possibility  of reaching much further back in time.","palabras_clave":"ancient proteins|placentals|South American native ungulates|phylogeny"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19755,"idioma_id":4,"titulo":"Resistance of foodborne pathogen coliphages to thermal and physicochemical treatments applied in food manufacture","resumen":"In the present work, six bacteriophages (DT1 to DT6) with lytic activity against one enteropathogenic (EPEC) and two Shiga-toxigenic (STEC) Escherichia coli strains were tested for their resistance to physicochemicalconditions\/treatments applied on food industry, either under conditionsfound in the food matrix such asdifferent pH, cation concentrations, and water activity (Aw), and\/or found during the manufacture process, namely thermal treatments at 63, 72 and 90 °C. Furthermore, phage viability was assessed at refrigeration and abusive temperature, different salt concentrations, and relevant pH values found in meat and dairy products. Phages were completely inactivated at 90°C, though DT2 and DT6 showed higher thermal resistance since phage particles were detected after 2 min. In addition, Tris-magnesium gelatin buffer seems to be the most protective suspension medium withincreasing temperature. Phage viability was slightly or moderately affected at 63 °C and 72 °C, respectively. All the cations evaluated showed no influence on phage viability, and the same was true for the low Aw values assayed, namely 9.5 and 9.0. The six phages tolerated pH treatments well, being more resistant to alkaline conditions (up to pH 11). Results showed that the activity of the phages evaluated was only partially affected ? at the lowest temperature (regarding control temperature; 37°C), with increasing Na+ concentration, and at the lowest pH value (regarding control pH; 7.5) ? and most tested conditions allow phages to multiply in the three pathogenic Escherichia coli strains evaluated. These results help to improve both selection of phages and time point, e.g. on a HACCP system, where phages may be applied on food during their manufacture in order to maximize phage effectiveness against pathogenic STEC and EPEC strains in the food chain. Therefore, the phages evaluated in this study could be used on several food matrices since they are viable and active in a wide range of environmental food conditions.","palabras_clave":"BACTERIOPHAGE|ESCHERICHIA COLI|PHAGE VIABILITY|LYTIC ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19756,"idioma_id":4,"titulo":"Inhibition Mechanism of Phosphate Ions on Chloride-Induced Crevice Corrosion of Alloy 22","resumen":"Alloy 22, a nickel-based alloy that belongs to the Ni-Cr-Mo family, shows an outstanding corrosion resistance in most environments. Alloy 22 was extensively studied regarding its crevice corrosion behavior both in pure chloride solutions and in solutions containing other ions such as nitrate, sulfate, and carbonate\/bicarbonate. Electrochemical tests were performed to study uniform and localized corrosion of Alloy 22 in a deaerated aqueous solution of 1 M NaCl and 1 M NaCl with different amounts of phosphate additions at 90°C and at pH near neutral. Results show that the addition of phosphate to the solution increased the length of the passive potential range. Moreover, results from two type of electrochemical tests showed that the addition of 0.3 M phosphate and higher completely eliminated the susceptibility of Alloy 22 to crevice corrosion. The excellent inhibitive effect of phosphate is comparable to that of nitrate already reported in the literature.&nbsp; Elemental analysis of the corroded area suggests that the incorporation of phosphate ions into the passive film could be responsible for the increased passivity of Alloy 22 in the studied solutions. The excellent inhibition behavior of phosphate ion could be explained by a combination of two mechanisms: (1) the buffering effect of the low pH solution inside the crevice and (2) the formation of a phosphatized protective layer on the edge of the active crevice.","palabras_clave":"N06022|LOCALIZED CORROSION|PASSIVITY|PHOSPHATE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19757,"idioma_id":4,"titulo":"Toll convexity","resumen":"A walk $W$ between two non-adjacent vertices in a graph $G$ is  called tolled if the first vertex of $W$ is among vertices from $W$  adjacent only to the second vertex of $W$, and the last vertex of  $W$ is among vertices from $W$ adjacent only to the second-last  vertex of $W$. In the resulting interval convexity, a set $Ssubset  V(G)$ is toll convex if for any two non-adjacent vertices $x,yin S$  any vertex in a tolled walk between $x$ and $y$ is also in $S$. The  main result of the paper is that a graph is a convex geometry (i.e.  satisfies the Minkowski-Krein-Milman property stating that any  convex subset is the convex hull of its extreme vertices) with  respect to toll convexity if and only if it is an interval graph.  Furthermore, some well-known types of invariants are studied with  respect to toll convexity, and toll convex sets in three standard  graph products are completely described.","palabras_clave":"convexity|graph theory"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19758,"idioma_id":5,"titulo":"Caninos domésticos con elevada infestación por garrapatas y patógenos bacterianos asociados en la Ciudad Autónoma de Buenos Aires","resumen":"La garrapata común del perro, Rhipicephalus sanguineus, es la garrapata más difundida en el mundo y es vector de diversos agentes patógenos, muchos de ellos zoonóticos, como Rickettsia massiliae. Se seleccionó un grupo de caninos con una elevada infestación por esta especie de garrapata,procedentes de dos barrios carenciados de la Ciudad Autónoma de Buenos Aires. Mediante PCR se estudió la presencia de los géneros Rickettsia, Ehrlichia y Anaplasma. Se detectó R. massiliae y Anaplasma platys en las garrapatas, y A. platys en los caninos. La presencia de perros y entornos muy infestados por garrapatas aumenta el riesgo de mordeduras a los humanos y por lo tanto la posibilidad de contagio de estos patógenos. Por ello, la educación para la promoción de la salud y la tenencia responsable de animales de compañía son fundamentales para la prevención de estas enfermedades","palabras_clave":"caninos|Rhipicephalus|Rickettsia|Anaplasma"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19759,"idioma_id":5,"titulo":"LA FORMACIÓN BALDE DE LEYES, UNA NUEVA UNIDAD ESTRATIGRÁFICA DE LA CUENCA TRIÁSICA DE MARAYES-EL CARRIZAL, SAN JUAN","resumen":"La cuenca de Marayes-El Carrizal, al sudeste de la provincia de San Juan, está constituida poruna sucesión continental de depósitos acumulados en una cuenca de rift. La estratigrafía clásicade la cuenca está integrada en orden estratigráfico por las Formaciones Esquina Colorada,Carrizal, y Quebrada del Barro. Estudios de sensores remotos de imágenes satelitales,sedimentológicos y paleontológicos han permitido identificar una nueva unidad estratigráfica enel techo de la Formación Quebrada del Barro coronando la sucesión en algunos sectores de lacuenca. Esta nueva unidad estratigráfica había sido considerada previamente en mapasgeológicos y estudios paleontológicos-estratigráficos como parte del suprayacente Grupo ElGigante (Cretácico) y\/o como parte de la Formación Quebrada del Barro. Sin embargo, elhallazgo de vertebrados fósiles con filiación jurásica inferior en esta unidad, permitió descartaresta unidad como parte del Grupo El Gigante. Por otro lado, diferencias notables en susedimentología, sumados a que la Formación Quebrada del Barro se caracteriza por una fauna devertebrados con clara vinculación triásica, también permitieron diferenciarla de la misma ydefinirla como una nueva unidad estratigráfica de la cuenca Marayes-El Carrizal. La nuevaunidad estratigráfica se define como Formación Balde de Leyes, nombre asignado por laproximidad a esta localidad, y conlleva a un nuevo arreglo estratigráfico para la cuenca.","palabras_clave":"BALDE DE LEYES|JURASICO|MARAYES|DINOSAURIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19760,"idioma_id":4,"titulo":"An experimental subunit vaccine based on Bluetongue virus 4 VP2protein fused to an antigen-presenting cells single chain antibodyelicits cellular and humoral immune responses in cattle, guinea pigs and IFNAR(&#8722;\/&#8722;) mice","resumen":"Bluetongue virus (BTV), the causative agent of bluetongue disease (BT) in domestic and wild ruminants,is worldwide distributed. A total of 27 serotypes have been described so far, and several outbreaks havebeen reported. Vaccination is critical for controlling the spread of BTV. In the last years, subunit vaccines,viral vector vaccines and reverse genetic-based vaccines have emerged as new alternatives to conventional ones. In this study, we developed an experimental subunit vaccine against BTV4, with the benefit of targeting the recombinant protein to antigen-presenting cells. The VP2 protein from an Argentine BTV4 isolate was expressed alone or fused to the antigen presenting cell homing (APCH) molecule, in the baculovirus insect cell expression system. The immunogenicity of both proteins was evaluated in guinea pigs and cattle. Titers of specific neutralizing antibodies in guinea pigs and cattle immunized with VP2 or APCH-VP2 were high and similar to those induced by a conventional inactivated vaccine. The immunogenicity of recombinant proteins was further studied in the IFNAR(&#8722;\/&#8722;) mouse model where the fusion of VP2 to APCH enhanced the cellular immune response and the neutralizing activity induced by VP2.","palabras_clave":"BLUE TONGUE|VACCINE |SUBUNIT|ANIMAL MODEL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19761,"idioma_id":5,"titulo":"Marxismo y feminismo: el recomienzo de una problemática","resumen":"This paper explores the potential capacity of Althusserian philosophy to intervene in the complex field of relations between Marxism &amp; Feminism. The potential of Althusserian perspective is focused on three interrelated aspects: it explores, on the one hand, the ideological concept of ideology as an obstacle which obscures the relationship between ideology and the relations of production. However, the paper stresses that without a materialist concept of ideology, gender issues remain as vindications that do not question the foundations of capitalism, with great difficulties to articulate their vindications with others (such as ethnical or class vindications). On the other side, it intends to open the theoretical space in order to think ?class? as heterogenic. As we will argue, that cannot be achieved without appealing to the Althusserian notions of overdetermination and social and economic formation, that is to say, the space where the ?society-effect? is produced and where multiple and distinct contradictions are developed and interrelated. This two concepts, overdetermination and ideology, both referred to a critique of empirism, that allows rethinking the traditional misunderstandings between Marxism &amp; Feminism, moving towards an anti-humanist, anti-economicist and materialist problematic. El presente trabajo explora la potencialidad de la filosofía althusseriana para intervenir en el campo complejo de las relaciones entre marxismo y feminismo. Esta potencialidad de la perspectiva althusseriana se examina en al menos tres aspectos relacionados: por una parte, se explora el obstáculo que representa una noción idealista de la ideología, al obturar su relación con las relaciones de producción, sin las cuales las cuestiones de género no pueden pasar de ser reivindicaciones en el interior del sistema capitalista, con grandes dificultades para articularse con otras reivindicaciones (étnicas o de clase). Por otra parte, se intenta abrir el espacio teórico para un concepto de clase heterogéneo, lo que entendemos que no se puede lograr sino a través del concepto althusseriano de sobredeterminación y del concepto de formación económico social, como el espacio en el que se produce el efecto de sociedad y donde se desarrollan contradicciones múltiples y desiguales. Estos conceptos, ideología y sobredeterminación, que van de la mano con la crítica al empirismo, permiten pensar la manera en que los límites externos de las clases repercuten en el interior de las mismas, llevando el malentendido clásico marxismo\/feminismo más allá de los límites en los cuales ha sido circunscripto, abriendo la posibilidad para repensarlo desde una problemática antihumanista, antieconomicista y materialista.","palabras_clave":"Feminismo|Género|Ideología|Sobredeterminación|Clases sociales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19762,"idioma_id":4,"titulo":"Introduction","resumen":"This special issue of Substance Use & Misuse explores?Big Events,? Substance Use, and Its Interventions: AGlobal Perspective. The term ?big events? refers to economiccrises like those currently taking place in theUSA and most European Union countries, economic depressionslike the ones occurring in Greece and Romania;and economic transformations like the one happeningin China. It also refers to political transitions likethose that have come about, and are currently occurringin different Arab or Latin American countries; as wellas wars or expanded violent conflicts like the ones inSyria or Sudan. The Big Events concept can also includea range of socially-disruptive mega-epidemics orperhaps some natural disasters like tsunamis, earthquakes,famines, droughts, or floods. The Special Issue wanted tofocus on and analyze conditions, whether internal or external,at micro to macro levels of analysis, that might createsocial and other changes that may in turn create differentforms of substance use and drug use-related harm.","palabras_clave":"BIG EVENTS|SUBSTANCE USE|INTERVENTIONS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19763,"idioma_id":5,"titulo":"'Introducción'","resumen":"Introducción al Dossier sobre Pueblos Indígenas en la producción antropológica argentina (1984-2014)","palabras_clave":"Pueblos indígenas|Antropología social|Etnología|Etnohistoria"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19764,"idioma_id":4,"titulo":"Gamma-ray binaries beyond one-zone models: An application to LS 5039","resumen":"Context. Several binary systems hosting massive stars present gamma-ray emission. In most of these systems, despite detailed observational information being available, the nature and the structure of the emitter are still poorly known. Aims: We investigate the validity of the so-called one-zone approximation for the high-energy emitter in binary systems hosting a massive star. In particular, the case of LS 5039 is considered. Methods: Assuming a point-like emitter at rest, the presence of a nearby massive star, and the observed MeV and GeV fluxes as a reference, a non-thermal leptonic model is systematically applied for different locations, magnetic fields, and non-radiative losses. This allows us to identify both the emitter configurations that are most compatible with observations and inconsistencies between model predictions and the available data. Results: In the case of LS 5039, the best parameter combination is fast non-radiative cooling and a low magnetic field. However, discrepancies appear when comparing the model results at the MeV and GeV energy ranges with the observed fluxes. Predictions fail when the orbital motion is included in the analysis, because emitters and energy budgets that are too large are required. Values of X-ray and TeV fluxes that are too high are predicted in such a case, along half of the orbit. Conclusions: We show that the radiation in LS 5039 does not come from only one electron population, and the emitter is likely extended and inhomogeneous with a low magnetic field. We suggest that the emitter moves at relativistic velocities with Doppler boosting playing a significant role.","palabras_clave":"radiation mechanisms: non-thermal|relativistic processes|stars: massive|X-rays: binaries"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19765,"idioma_id":4,"titulo":"A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein","resumen":"Modern subunit vaccines require the development of new adjuvant strategies. Recently, we showed that CpGODN formulated with a liquid crystal nanostructure formed by self-assembly of 6-O-ascorbyl palmitate (CoaASC16) is an attractive system for promoting an antigen-speci&#64257;c immune response to weak antigens. Here, weshowed that after subcutaneous injection of mice with near-infrared &#64258;uorescent dye-labeled OVA antigen formulated with Coa-ASC16, the dye-OVA was retained at the injection site for a longer period than when soluble dyeOVA was administered. Coa-ASC16 alone elicited a local in&#64258;ammation, but how this material triggers this response has not been described yet. Although it is known that some materials used as a platform are not immunologically inert, very few studies have directly focused on this topic. In this study, we explored the underlying mechanisms concerning the interaction between Coa-ASC16 and the immune system and we found that thewhole in&#64258;ammatory response elicited by Coa-ASC16 (leukocyte recruitment and IL-1&#946;, IL-6 and IL-12 production) was dependent on the MyD88 protein. TLR2, TLR4, TLR7 and NLRP3-in&#64258;ammasome signaling were not required for induction of this in&#64258;ammatory response. Coa-ASC16 induced local release of self-DNA, and in TLR9de&#64257;cientmice IL-6 production was absent. In addition, Coa-ASC16 revealed an intrinsic adjuvant activity which was affected by MyD88 and IL-6 absence. Taken together these results indicate that Coa-ASC16 used as a vaccine platform is effective due to the combination of the controlled release of antigen and its intrinsic proin&#64258;ammatoryactivity. Understanding how Coa-ASC16 works might have signi&#64257;cant implications for rational vaccine design.","palabras_clave":"LIQUID CRYSTAL |ASCORBYL PALMITATE|NANOESTRUCTURE|VACCINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19766,"idioma_id":4,"titulo":"Seek, and ye shall find: Differences between spontaneous and voluntary analogical retrieval","resumen":"The present study tackles two overlooked aspects of analogical retrieval: (a) whether argumentation  activities elicit a spontaneous search for analogical sources, and (b) whether strategic search can relax  the superficial bias typically obtained in experimental studies of analogical retrieval. In Experiment 1,  participants had to generate arguments for a target situation under three conditions: without indication  to use analogies, with indication to use analogies, and with indication to search for sources within  domains provided by the experimenters. Results showed that while voluntary search yields analogical  retrievals reliably, the argumentation activity seldom elicits spontaneous remindings. A second set of  results demonstrated that the superficial bias can be strategically relaxed, leading to a majority of  distant retrievals. Experiment 2 replicated this result with the instruction to search within domains  different from that of the target, and without providing a list of specific domains. The theoretical  and educational implications of these findings are discussed.","palabras_clave":"ANALOGY|RETRIEVAL|STRATEGIC SEARCH|SURFACE SIMILARITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19767,"idioma_id":4,"titulo":"Effect of Environmental Variables on Crevice Corrosion Susceptibility of Ni-Cr-Mo Alloys for Nuclear Repositories","resumen":"The crevice corrosion repassivation potential was determined by the Potentiodynamic-Galvanostatic-Potentiodynamic(PD-GS-PD) method. Alloys 625, C-22, C-22HS and HYBRID-BC1 were used. Specimens contained 24 artificially crevicedspots formed by a ceramic washer (crevice former) wrapped with a PTFE tape. Crevice corrosion tests were performed in 0.1 mol\/L and 1 mol\/L NaCl solutions at temperatures between 20 and 90ºC, and CaCl2 5 mol\/L solution at temperatures between 20 and 117°C. The crevice corrosion resistance of the alloys increased in the following order: 625 &lt; C-22 &lt; C-22HS &lt; HYBRID-BC1. The repassivation potential (ECO) showed the following relationship with temperature (T) and chloride concentration ([Cl-]) ECO = (a + b T) log [Cl-] + c T + d; where a, b, c and d are constants. At temperatures above 90°C, ECO for alloy 625 stabilized at a minimum value of -0.26 VSCE.","palabras_clave":"LOCALIZED CORROSION|REPASSIVATION POTENTIAL|TEMPERATURE|CHLORIDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19768,"idioma_id":4,"titulo":"Determining the Effect of the Main Alloying Elements on Localized Corrosion in Nickel Alloys using Artificial Neural Networks","resumen":"Nickel base alloys are considered among candidate materials for engineered barriers of nuclear repositories. The localizedcorrosion resistance is a determining factor in materials selection for this application. This work compares the crevice corrosionresistance of several commercial nickel base alloys using artificial neural networks. The crevice corrosion repassivation potentialof the tested alloys was determined by the potentiodynamic-galvanostatic-potentiodynamic (PD-GS-PD) method. The testingtemperature was 60ªC and the chloride concentrations used were 0,1M, 1M and 10M.The results indicate that the repassivation potential increases linearly with the PREN (Pitting Resistant Equivalent Number) at high chloride concentrations. We also found a linear relationship between the repassivation potential and the logarithm of the concentration of chloride. Analysis from artificial neural networks presents distinctive patterns between the mayor alloying components and the chloride concentration and the repassivation potential. Predictions from artificial neural networks fit with successive tested commercial nickel alloys.","palabras_clave":"ARTIFICIAL NEURAL NETWORKS|CREVICE CORROSION|REPASSIVATION POTENTIAL|CHLORIDES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19769,"idioma_id":4,"titulo":"Marine Lactobacillus pentosus H16 protects Artemia franciscana from Vibrio alginolyticus pathogenic effects","resumen":"Vibrio alginolyticus is an opportunistic pathogen which may affect different aquatic organisms. The aim of this study was to assess the probiotic properties and the protective mode of action of Lactobacillus pentosus H16 against V. alginolyticus 03\/8525, through in vitro and in vivo studies using Artemia franciscana. This strain showed antimicrobial activity against V. alginolyticus 03\/8525 and Aeromonas salmonicida subsp. salmonicida ATCC33658 possibly related with lactobacilli organic acid production. It was able to survive at high rainbow trout bile concentrations and showed high selective adhesion to rainbow trout mucus (1.2 E+05 ± 8.0 E+03 cells\/cm2). H16 outcompeted with V. alginolyticus 03\/8525 and A. salmonicida subsp. salmonicida ATCC33658, greatly reducing their adherence to rainbow trout mucus (64.8 and 74.1 %, respectively). Moreover, H16 produced a cell-bound biosurfactant which caused an important diminution of the surface tension. H16 also protected Artemia nauplii against mortality when it was administered previously to V. alginolyticus 03\/8525 inoculation. Furthermore, H16 bioencapsulated in Artemia suggesting that it is possible to use live carriers in its administration. We conclude that the capability of L. pentosus H16 to selectively adheres to mucosal surfaces and produces cell-bound biosurfactants, displacing pathogenic strains, in addition to its antimicrobial activity, confer H16 competitive advantages against pathogens as demonstrated in vivo challenge experiments. Thus, L. pentosus H16, a marine bacterium from the intestinal tract of hake, is an interesting probiotic for Artemia culture and has also potential in the prevention of vibriosis in other aquaculture activities such as larvae culture and fish farming.","palabras_clave":"PROBIOTIC|ARTEMIA|VIBRIOSIS|LACTOBACILLUS PENTOSUS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19770,"idioma_id":4,"titulo":"The Movement of Popular and Neighborhood Assemblies in the City of Buenos Aires, 2002-2011","resumen":"The assembly movement of Buenos Aires was one of the main political actors that emerged with the social explosion of December 2001. It initially called for a complete renewal of the country´s elites, but it gradually divided into a sector that focused on neighborhood demands and a sector that adopted a national perspective. A detailed examination of a decade of development of two assemblies that are paradigmatic examples of the movement´s division show that they retained their political identities over time, with the result that the 'neighborhood' assembly disbanded once the problems on which it had concentrated were considered resolved while the 'popular' assembly continued to engage in cultural and political projects.","palabras_clave":"Social movements|Assembly movement|Movement outcomes|Argentina"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19771,"idioma_id":4,"titulo":"Th17 and Th17\/Treg ratio at early HIV infection associate with protective HIV-specific CD8(+) T-cell responses and disease progression","resumen":"The aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute\/early) primary HIV infection (PHI) and up to one year post-infection (p.i). Samples from 14 healthy donors (HDs), 40 PHI patients, 17 Chronics, and 13 Elite controllers (ECs) were studied. The percentages of Th17 and Treg subsets were severely altered in Chronics, whereas all HIV-infected individuals (including ECs) showed Th17\/Treg imbalance compared to HDs, in concordance with higher frequencies of activated CD8(+) T-cells (HLA-DR(+)\/CD38(+)). Better clinical status (higher CD4 counts, lower viral loads and activation) was associated with higher Th17 and lower Treg levels. We found positive correlations between Th17 at baseline and anti-HIV CD8(+) T-cell functionality: viral inhibitory activity (VIA) and key polyfunctions (IFN-&#947;(+)\/CD107A\/B(+)) at both early and later times p.i, highlighting the prognostic value of Th17 cells to preserve an effective HIV T-cell immunity. Th17\/Treg ratio and the IL-17 relative mean fluorescence intensity (rMFI of IL-17) were also positively correlated with VIA. Taken together, our results suggested a potential link between Th17 and Th17\/Treg ratio with key HIV-specific CD8(+) T-cell responses against the infection.","palabras_clave":"Th17|Treg|PHI|CD8 T-cell responses"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19772,"idioma_id":4,"titulo":"An integral formula for multiple summing norms of operators","resumen":"We prove that the multiple summing norm of multilinear operators defined on some n-dimensional real or complex vector spaces with the p-norm may be written as an integral with respect to stable measures. As an application we show inclusion and coincidence results for multiple summing mappings. We also present some contraction properties and compute or estimate the limit orders of this class of operators.","palabras_clave":"Absolutely summing operators|Multilinear operators|Multiple summing operators|Stable measures"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19773,"idioma_id":4,"titulo":"Gold Nanoparticles Supported in Zirconia-Ceria Mesoporous Thin Films: A Highly Active Reusable Heterogeneous Nanocatalyst","resumen":"Gold nanoparticles (NP) trapped in the mesopores of mixed zirconia?ceria   thin films are prepared in a straightforward and reproducible way. The   films exhibit enhanced stability and excellent catalytic activity in   nitro-group reduction by borohydride and electrocatalytic activity in CO   and ethanol oxidation and oxygen reduction","palabras_clave":"mesoporous materials|thin films|gold catalysis|zirconia ceria|electrocatalysis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19774,"idioma_id":4,"titulo":"Potassium chloride production by microcline chlorination","resumen":"The potassium chloride is one of the most important fertilizers used in agriculture. The current demandof this salt makes interesting the study of potassium chloride production from unconventional potassiumresources. In thiswork the potassium chloride production by chlorination of microclinewas investigated.The starting reagents were microcline, hydromagnesite and chlorine.Non-isothermal and isothermal chlorination assays were carried out in a thermogravimetric deviceadapted to work in corrosive atmospheres. The temperature effect on potassium extraction and the phasetransformations produced during chlorination of microcline were studied. The reagents and reactionproducts were analyzed by X-ray fluorescence (XRF) and X-ray diffraction (XRD). The experimentalresults indicated that by chlorination of microcline an important extraction of potassium in thetemperature range from 800 to 900 C was produced. Moreover, at 800 C the forsterite, enstatite andmagnesium aluminate spinel phases were generated.","palabras_clave":"CHLORINATION|POTASSIUM|MICROCLINE|FORSTERITE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19775,"idioma_id":5,"titulo":"Pinturas rupestres en un espacio funerario: el caso del sitio Cueva Galpón (departamento de Valcheta, Río Negro).","resumen":"En este trabajo se presentan los primeros resultados del estudio del arte rupestre del sitio Cueva Galpón (noreste de la Patagonia, Argentina). Las evidencias arqueológicas halladas en la cueva estánrepresentadas por dos entierros humanos y pinturas rupestres rojas, negras y blancas. El análisis está orientado a evaluar la variabilidad interna del arte, plantear una secuencia de producción y discutir su contexto arqueológico. Los dos primeros objetivos se abordan mediante la caracterización formal de losmotivos, el análisis de las superposiciones y la evaluación del estado de preservación. La contextualización se resuelve en las escalas intrasitio e intersitio. En la primera se evalúa el grado de relación entre laspinturas y los eventos mortuorios, y en la segunda se analizan las similitudes y diferencias con el arte rupestre de la región para discutir sus implicancias estilísticas, tecnológicas y cronológicas. Los resultados sugieren un piso cronológico de ca. 3.000 años para la ejecución de los motivos (lo cual coincide con las fechas obtenidas en uno de los entierros humanos) y un uso diacrónico de la cueva tanto para la producción de imágenes como para las inhumaciones. Se propone una probable interdependencia entre ambas prácticas y se discute el carácter inusual de esta asociación en el contexto arqueológico regionaldel Holoceno tardío.","palabras_clave":"Norpatagonia|Holoceno tardío|Arte rupestre"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19777,"idioma_id":4,"titulo":"Prospection and molecular analysis of CpGV isolates infecting Cydia pomonella at different geographical locations in Argentina","resumen":"The occurrence and genetic diversity of Cydia pomonella granulovirus infecting C. pomonella across Argentina were investigated. Larvae were collected from fruit orchards in regions where CpGV-based biopesticides have been extensively used and then discontinued (Catamarca) or are still being used (Alto Valle). The survey was also extended to regions where few occasional (i.e. Mendoza) or no virus treatments (various locations) have been made. PCR analysis showed an unexpectedly high proportion of infected larvae (31.3?50%) at most sampling sites in Catamarca. Phylogenetic analysis of these samples, based on gran and lef-8 genes partial sequences, revealed a previously unreported CpGV variant which could not be assigned to any of the known CpGV genome types and formed a well-defined new cluster. Instead, samples from Alto Valle were genetically similar to isolate CpGV-M (the active ingredient in commercial formulations). There, the percentage of infected individuals was considerably lower (1.8?21.9%). The virus was not detected in Mendoza or the other sampling regions. Implications of these results on the epidemiology and current classification of CpGV isolates are discussed.","palabras_clave":"BACULOVIRIDAE|CPGV|LEPIDOPTERA|CYDIA POMONELLA|GENETIC DIVERSITY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19778,"idioma_id":4,"titulo":"Genome sequence of Bradyrhizobium japonicum strain E109, a model of nitrogen fixing rizobacteria successfully used in agriculture.","resumen":"We present here the complete genome sequence of Bradyrhizobium japonicum strain E109, one of the most used rhizobacteria for soybean inoculation in Argentina since the 1970s. The genome consists of a 9.22-Mbp single chromosome and contains several genes related to nitrogen fixation, phytohormone biosynthesis, and a rhizospheric lifestyle.","palabras_clave":"GENOME|SEQUENCE|BRADYRHIZOBIUM|RIZOBACTERIA"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19779,"idioma_id":5,"titulo":"Chamanes, guerreros, felinos. Iconografia de transmutación en el noroeste de Córdoba (Argentina).","resumen":"Se desarrolla un análisis del arte rupestre del noroccidente de Córdoba (Argentina), con especial énfasis en las expresiones del alero Salamanca de la Aguada. Las diferencias tonales y las acciones de repintado permiten distinguir tres momentos de ejecución. La sucesiva incorporación de imágenes modificó la temática original, fundada en las figuras de camélidos, por el agregado de nuevos referentes como antropomorfos, motivos no figurativos y en menor medida pisadas. Este cambio repite una secuencia observada en otros sitios de la región, entendida en términos de desactualización de una determinada temática e imposición de otra nueva. Entre los agregados se destaca una escena compuesta por antropomorfos alineados, con indicación de vestimentas confeccionadas con pieles de jaguar u otro felino moteado. Se analiza información arqueológica, histórica y etnográfica, tanto a nivel local como macrorregional, con el propósito de contextualizar el caso de estudio y desarrollar una hipótesis que define a dichas vestimentas como una indumentaria de transmutación. Finalmente, se intenta vincular la implantación y desarrollo de determinadas formas ideológicas y prácticas sociales en la región con los procesos políticos y culturales del Período Prehispánico Tardío, comprendiendo los siglos finales previos a la conquista española.","palabras_clave":"Arte Rupestre|metamorfosis humana-felino|imposición iconográfica|tensiones sociales"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19780,"idioma_id":4,"titulo":"CONSTITUTIVE AND GHRELIN-DEPENDENT GHSR1A ACTIVATION IMPAIRS CAV2.1 AND CAV2.2 CURRENTS IN HYPOTHALAMIC NEURONS","resumen":"The growth hormone secretagogue receptor type 1a (GHSR1a) has the highest constitutive activity of any G protein coupled receptor (GPCR). GHSR1a mediates the action of the hormone ghrelin and, its activation increases transcriptional and electrical activity in hypothalamic neurons. It is known that GHSR1a is present at GABAergic presynaptic terminals; however, its impact on neurotransmitter release remains elusive. The voltage gated calcium channels, CaV2.1 and CaV2.2, control neurotransmitter reléase at presynaptic terminals and their activities are modulated by many GPCRs. Here we show that constitutive as well as agonist-dependent GHSR1a activity trigger a strong impairment of both CaV2.1 and CaV2.2 currents in rat and mouse neurons and in a heterologous expression system. Constitutive GHSR1a activity reduces CaV2 currents by a Gi\/odependent mechanism that involves persistent reduction in channel density at plasma membrane, whereas, ghrelin-dependent GHSR1a inhibition is reversible and involves altered CaV2 current gating via a Gq-dependent pathway. Thus, we show that GHSR1a differentially inhibits CaV2 channels by Gi\/o- or Gq-protein pathways depending on its activation mode. Moreover, we present evidence suggesting that GHSR1a-mediated inhibition of CaV2 impairs GABA release in hypothalamic neurons, a mechanism that could contribute to neuronal activation by the disinhibition of postsynaptic neurons.","palabras_clave":"GHSR1a|voltage gated calcium channels"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19781,"idioma_id":4,"titulo":"Diffusive phenomena and pseudoelasticity in Cu Al Be single crystals","resumen":"Cu?Al?Be single crystals show pseudoelasticity and the shape memory effect in a well-defined composition range. The beta3-18R martensitic transition is the origin of these phenomena. The transformation temperatures and the critical stresses to induce the martensitic transition are affected by diffusive phenomena taking place both in the parent phase and in martensite. Pseudoelastic cycles were used to obtain quantitative data concerning the effect of diffusive phenomena like stabilization of martensite, ordering of the parent phase under load and recovery of this phase on the critical stresses to transform. Information was then obtained on changes in the relative phase stability. A model is presented to explain those changes taking place in the parent phase aged under load and in the martensitic 18R structure. Experimental data on the kinetics of diffusive phenomena is also presented and analyzed.","palabras_clave":"metals and alloys|shape memory|phase transitions|diffusion|thermodynamic modeling"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19782,"idioma_id":4,"titulo":"Comment on 'Isothermal nature of the B2-B19´ martensitic transformation in a Ti-51.2 Ni (at.%) alloy'","resumen":"Fukuda et al. published a paper (Scripta Mater. 68 (2013) 984?987) in which they claimed to be able to determine the isothermal nature of the martensitic transformation in a Ti?Ni alloy. They analyzed the evolution of electrical resistance during isothermal holding stages and concluded that the variations were a consequence of the isothermal transition between austenite and martensite. In the following we will demonstrate that the discussed data do not allow the interpretation presented and that the isothermal nature is not proved.","palabras_clave":"thermal activation|titanium-nickel alloy|shape memory alloy|nucleation"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19783,"idioma_id":4,"titulo":"Influence of the support material on the activity and selectivity of Ru-Sn-B catalysts for the selective hydrogenation of methyl oleate","resumen":"The influence of the kind of support (Al2O3, SiO2 and TiO2) on the catalytic activity and selectivity of Ru-Sn-B catalysts for the hydrogenation of methyl oleate to oleyl alcohol was studied. The results show that the most active and selective catalyst for producing oleyl alcohol is Ru(1%)-Sn(2%)-B\/Al2O3. This was attributed to the catalyst having a favorable surface Sn\/Ru ratio (=2). The SiO2-supported Ru-Sn-B catalyst had a good activity and hydrogenated both C=C double bonds and the C=O group, thus producing stearyl alcohol with a high yield. It however deactivated to a great extent, its final conversion being lower than that of the bimetallic catalysts supported on Al2O3 and TiO2. The TiO2 supported catalyst had a high selectivity to saturated methyl esters because it hydrogenated C=C double bonds but had little activity for hydrogenation of the C=O group.","palabras_clave":"SELECTIVE HYDROGENATION|METHYL OLEATE|Al2O3|TiO2"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19784,"idioma_id":4,"titulo":"Role of angiotensin II and oxidative stress in renal inflammation by hypernatremia: Benefits of atrial natriuretic peptide, losartan, and tempol","resumen":"The body regulates plasma sodium levels within a small physiologic range, despite large variations in daily sodium and water intake. It is known that sodium transport in the kidneys plays an important role in hypoxia, being the major determinant of renal oxygen consumption. Tubular epithelial cell hypoxia is an important contributor to the development of renal inflammation, and the damage may progress to structural injury, ending in acute renal failure. In this review, we will summarize the renal inflammatory effects of high acute plasma sodium (acute hypernatremia), and the molecular mechanisms involved. We will also discuss recent findings related to the role of oxidative stress and angiotensin II (Ang II) in the pathogenesis of renal injury. We will comment on the effects of agents used to prevent or attenuate the inflammatory response, such as the atrial natriuretic peptide, the superoxide dismutase mimetic - tempol, and losartan.","palabras_clave":"ANGIOTENSIN|HIPERNATREMIE|INFLAMMATION|OXIDATIVE STRESS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19785,"idioma_id":4,"titulo":"Peer collaboration in childhood according to age, socioeconomic context and task","resumen":"From a socio-constructivist approach, this work aimed to analyze the characteristics of peer collaboration in dyads of children according to age (4, 8, and 12 years old), socioeconomic context (advantaged socioeconomic context and disadvantaged socioeconomic context), and task (block construction task and free drawing). Eighty-two children (41 dyads) completed both collaborative tasks. Interaction was videotaped and transcribed in terms of verbal and non-verbal behaviors. Interaction was analyzed by a system of exhaustive and mutually exclusionary socio-behavioral categories. The results suggested that age group and task were related to the main differences in peer collaboration. On one hand, dissociation was a typical scene of 4-year-old dyads, whereas the more socially integrated categories, i.e., Implicit Cooperation, Explicit Cooperation, Collaboration and Conversation Related to Task without Execution, prevailed at 8 and 12 years old. On the other hand, differences associated with the task were referred with codes of higher social coordination. That is, the categories that not necessarily imply a distribution of functions on the basis of an oral agreement predominated in block construction task, as occurred in implicit cooperation and collaboration. In contrast, categories of verbal social regulation of roles (explicit cooperation or conversation related to task without execution) predominated in free drawing. Socioeconomic context influenced on fewer categories compared to the age group and task. The findings are discussed in terms of its developmental and contextual implications, and above all, in relation to the socio-behavioral level (regulated by verbalization) of collaborative interaction.","palabras_clave":"PEER COLLABORATION|COLLABORATIVE LEARNING|DEVELOPMENTAL PSYCHOLOGY|SOCIOECONOMIC CONTEXT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19786,"idioma_id":4,"titulo":"Lepton number violation and neutrino masses in 3-3-1 models","resumen":"Lepton number violation and its relation to neutrino masses is investigated in several versions of the SU(3)c &#8855; SU(3)L &#8855; U(1)x model. Spontaneous and explicit violation and conservation of  the lepton number are considered. In one of the models (the so-called economical one), the lepton  number is spontaneously violated and it is found that the would be Majoron is not present because  it is gauged away, poviding in this way the longitudinal polarization component to a now massive  gauge field.  PACS numbers: 11.30.Fs, 12.60.Fr, 14.60.Pq","palabras_clave":"LEPTON NUMBER|331 MODEL|NEUTRINOS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19787,"idioma_id":4,"titulo":"Analytic Structure of the S-Matrix for Singular Quantum Mechanics","resumen":"The analytic structure of the S-matrix of singular quantum mechanics is examined within a multichannel framework, with primary focus on its dependence with respect to a parameter ($Omega$) that determines the boundary conditions. Specifically, a characterization is given in terms of salient mathematical and physical properties governing its behavior. These properties involve unitarity and associated current-conserving Wronskian relations, time-reversal invariance, and Blaschke factorization. The approach leads to an interpretation of effective nonunitary solutions in singular quantum mechanics and their determination from the unitary family.","palabras_clave":"S-matrix theory|Quantum mechanics|Boundary value problems|Singularity theory"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19788,"idioma_id":5,"titulo":"Investigaciones arqueofaunísticas en el Fortín La Parva (1858)","resumen":"El objetivo de este trabajo es presentar las investigaciones arqueofaunísticas realizadas en el sitio Fortín La Parva (1858), General Alvear, provincia de Buenos Aires, focalizando los diferentes usos espaciales del área a través del análisis del registro arqueológico y de análisis de fuentes documentales escritas relevadas en diferentes repositorios. La concentración de artefactos de origen europeo recuperados y el análisis de datos provenientes de documentos escritos de la época, han aportado evidencias tanto sobre los materiales que se utilizaron para construir el fortín como de la vida cotidiana en la frontera de mediados del siglo XIX. Se destaca la presencia de ítems de uso doméstico, en un contexto asociado a fragmentos de armas junto con material óseo alterado térmicamente por prácticas de combustión.","palabras_clave":"FORTÍN LA PARVA|ARQUEOFAUNÍSTICAS|REGISTRO ARQUEOLÓGICO|SIGLO XIX"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19789,"idioma_id":4,"titulo":"Bioerosion structures in Crepidula (Mollusca, Gastropoda) as indicators of latitudinal palaeoenvironmental changes: Example from the marine Quaternary of Argentina","resumen":"Late Quaternary marine skeletal concentrations from Argentina are rich in molluscs exhibiting a great variety of bioerosion structures. The shells of Crepidula, a characteristic gastropod occurring along more than 2000 km of coastline between the Río de La Plata margin and southern Patagonia, show traces of dwelling, predation and anchoring activities made by porifers, bryozoans, annelids, other gastropods and brachiopods. Caulostrepsis, Entobia, Maeandropolydora, Iramena, Oichnus, Finichnus, Pennatichnus, Pinaceocladichnus, Podichnus and Renichnus occur on the outer shell surface. Finichnus and Oichnus are the only traces present along the entire area and the full time span considered. The most characteristic structures are produced by bryozoans, polychaetes and predatory gastropods. Traces produced by annelids and predatory gastropods occur preferentially in the central shell sector, where predators gained access to the soft parts of the prey. By contrast, encrusting or branching bryozoan colonies are widely distributed as they can attach to any sector regardless of shell features available. No strict correlation is evident between ichnodiversity and either time or latitude, but ichnodiversity is linked to local oceanographical\/biotic controls. For Patagonia, with a great majority of ichnotaxa made by bryozoans, the general trend of higher bioerosion degree and ichnodiversity at higher latitudes is controlled by sea surface temperature\/ productivity: for the modern and the Holocene, several ichnodiversity peaks match with well-constrained conditions (substrate, salinity, thermal fronts). By contrast, this does not hold for the Pleistocene: dissimilar conditions probably prevailed, especially during the Last Interglacial (colder waters richer in nutrients).","palabras_clave":"ICHNODIVERSITY|GEOGRAPHICAL VARIATIONS|HOLOCENE|PLEISTOCENE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19790,"idioma_id":5,"titulo":"Imágenes y narración: Análisis de un espacio pedagógico con niñas y niños en situación de calle","resumen":"En este artículo analizamos los aprendizajes que se realizaron en el marco de un espacio pedagógico que tuvo como objetivo central la alfabetización en diferentes lenguajes dirigido a niñas y niños en situación de calle. Para esto partimos del concepto de aprendizaje en interacción (Heras, 1993; 1995 y 1999) y analizamos los distintos productos generados en el marco del taller (un cuento, dibujos, maquetas y collages realizados por los chicos). En las conclusiones destacamos la importancia de los procesos de interacción (con otros y con el medio) y la inclusión de formas de expresión diferentes a las hegemónicas ligadas con la lectura y la escritura para la generación de aprendizajes. Finalmente, evaluamos las posibilidades y limitaciones de propuestas pedagógicas de este tipo y mencionamos algunos aprendizajes que pueden ser útiles para equipos de trabajo que deseen encarar experiencias pedagógicas como la que aquí se analiza.","palabras_clave":"IMÁGENES|NARRACIÓN|SITUACIÓN DE CALLE|AUTONOMÍA Y AUTOGESTIÓN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19791,"idioma_id":4,"titulo":"PANGAS: An Interdisciplinary Ecosystem-Based Research Framework for Small-Scale Fisheries in the Northern Gulf of California","resumen":"          The PANGAS project, (Pesca  Artesanal del Norte del Golfo de California: Ambiente y Sociedad\/ Small-Scale Fisheries of the Northern Gulf of  California: Society and the Environment) was founded in 2005 as a long-term interdisciplinary project for research  and management of small-scale fisheries in the Northern Gulf of California  (NGC). &nbsp;It was structured as a  bi-national partnership between three academic institutions and three NGOs to  support the Mexican government for fisheries management and marine conservation.  &nbsp;The NGC ecosystem extends from San  Francisquito (Baja California) and Bahía Kino (Sonora), including San Pedro Mártir  Island in the south, to the Colorado River delta in the north with two extremely  productive and highly bio-diverse subregions, the Upper Gulf of California and  the Midriff Islands region. The region has an annual catch of ca. 18,000 metric  tons of more than 80 species of fish and invertebrates, consumed primarily in  the southwestern United States, eastern Asia and central Mexico.          In its first decade PANGAS developed a framework for ecosystem-based  research andmanagement of small-scale fisheries and tested it in the NGC. This interdisciplinary  framework included the identification of key ecosystems and small-scale  fisheries that can serve as representative proxies, with the use of rapid  appraisal techniques to characterize and select key fisheries and fishing  communities represented in a spatial and temporal dimension. Biophysical and  governance information was generated and collected for each proxy species  selected from the rocky reef ecosystem, and one species from wetland systems, the  blue crab. Several methods were used to assess the biophysical environment: 1)  we generated hypothesis for marine connectivity via larval dispersal by developing  coupled biological oceanographic models (CBOM´s) using oceanographic field data  and validated this with empirical population genetics and field subtidal  monitoring; 2) we identified and characterized key habitats; and, 3) we developed  population dynamic models. &nbsp;To describe  governance in fisheries, PANGAS identified rules in use and incentives for  compliance and social networks for the fishers living in the 17 permanent  fishing camps and towns along the 3,000 km coastline of the NGC. PANGAS products include, among others:  collection of critical life history information for more than 10 commercial  species; development of the first CBOM´s validated with genetic data for 7  species in the NGC; development of the first region-wide maps depicting  multi-species and multi-community fishing activities; training of at least 50  fishers from 4 fishing communities in subtidal monitoring techniques and  collection of fishery data; training of 23 undergraduate, graduate, and postdoc  students from Latin America, the United States and Europe on various aspects of  marine ecosystem-based research and management; publication of over 100  scientific papers, reports, protocols and thesis; production of management  recommendations in various official (government backed and\/or produced) and  non-official formats.          We present  the story of the PANGAS collaboration, provide examples for each step of the PANGAS  interdisciplinary framework and discuss the various challenges that PANGAS  faced to emerge with a series of lessons learned. &nbsp;We also point to future challenges and  describe current efforts to synthesize, archive, communicate and follow-up  PANGAS information in databases and incorporating it into management. Finally, we  highlight examples of collaboration between PANGAS and government agencies for  single and multispecies fisheries and show how an interdisciplinary approach can  inform the design and implementation of a new generation of strategies for marine  ecosystem-based research and management in Mexico and Latin-America.  ","palabras_clave":"EBM|FISHERIES|MANAGEMENT|CONSERVATION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19792,"idioma_id":4,"titulo":"THE FLAT TO NORMAL SUBDUCTION TRANSITION STUDY TO OBTAIN THE NAZCA PLATE MORPHOLOGY USING HIGH RESOLUTION SEISMICITY DATA FROM THE NAZCA PLATE IN CENTRAL CHILE","resumen":"Data from 45 seismological stations mostly temporary were used to obtain an accurate data set of intraslab seismicity of the Nazca subducted plate between 33°S to 35°S. The interest zone located in the transition section where the Nazca plate changes from flat slab north of ~33° to normal slab south of that latitude. In addition, the study region is located where the active volcanic arc appears. From a set of earthquakes which were relocated using a grid-search multiple events algorithm we obtained the plate geometry from latitudes of 33°S to 34.5°S and from 60 km to 120 km in depth. The obtained morphology shows notable similarity in its structure to Maipo Orocline revealing some possible strong connection between the overriding plate and the subducting plate.  We suggest that the subducted plate at the trench has been deformed in its shape consistently with the Maipo Orocline pattern and its deformation is observed below the interface zone. Our results are consistent with van Keken et al 2011 models, and based on this the seismicity located between 70-120 km is probably related with dehydration processes rather than mechanical processes. From our precise earthquake locations we observed a complete lack of intraslab seismicity below 120 km depth. This valuable finding can be used to better constrain thermal models for the subduction region of Central Chile.","palabras_clave":"intraslab-depth earthquakes |subducted slab morphology|subduction zones"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19793,"idioma_id":4,"titulo":"Liquid phase dehydration of 1-indanol: Selective synthesis of indene over microporous acid catalysts","resumen":"The selective dehydration  of 1-indanol in liquid-phase was studied at 363 K and 2 bar, over solid acid  catalysts, and using cyclohexane as a solvent. Mesoporous SiO2-Al2O3  with a high density of strong Lewis acid sites produced di-1-indanyl ether and  other heavy products apart from indene. In contrast, the overall selectivity to  indene with beta zeolite (HBEA, Si\/Al= 12.5), HZSM-5 (Si\/Al= 20) and  dealuminated mordenite zeolite (HMOR, Si\/Al= 80) was almost 100%. The transition  state shape selectivity and a moderate density of both Lewis and Brønsted acid  sites were crucial to achieve high selectivity to indene. In spite of the high  overall selectivity, the final yield in indene with HBEA was only 55%. This was  attributed to the formation of heavy compounds inside the large cavities of  HBEA, which cannot diffuse through its micropores. In contrast, yields in  indene higher than 90% were obtained with HMOR and HZSM-5. It was also observed  that the yield in indene increased with time even after reaching the 1-indanol total  conversion, which indicates the slow diffusion of the reactant and product  molecules inside of the microporous network of HMOR and HZSM-5. Therefore, a  process involving liquid phase dehydration of 1-indanol, employing one of these  two zeolites as a catalyst would provide: 1) high yield in indene; 2) easy  separation of product from solvent; 3) easy separation of the catalyst from the  reaction medium.","palabras_clave":"indenes|1-indanol dehydration|acid catalysis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19794,"idioma_id":4,"titulo":"Revalorization of Rice Husk Waste as a Source of Cellulose and Silica","resumen":"Cellulose and silica were obtained from rice husk by a multi-step procedure. Three different strategies including different alkaline and bleaching steps were evaluated by Fourier transform infrared spectroscopy (FTIR) in order to choose the sequence that combines the better conditions to obtain both subproducts simultaneously. The effects of the different steps on the structure and morphology of original material treated by the selected procedure were analyzed by X-ray diffraction (XRD), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The results suggest that it is possible to obtain both by-products with a simple procedure, giving an added value to this waste.","palabras_clave":"RICE HUSK|SILICA|CELLULOSE|THERMAL TREATMENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19795,"idioma_id":4,"titulo":"Environmental Selection Pressures Related to Iron Utilization Are Involved in the Loss of the Flavodoxin Gene from the Plant Genome","resumen":"            Oxidative stress and iron limitation represent  the grim side of life in an oxygen-rich atmosphere. The versatile electron  transfer shuttle ferredoxin, an iron-sulfur protein, is particularly sensitive  to these hardships, and its down-regulation under adverse conditions severely  compromises survival of phototrophs. Replacement of ferredoxin by a stress-resistant  isofunctional carrier, flavin-containing flavodoxin, is a widespread strategy  employed by photosynthetic microorganisms to overcome environmental  adversities. The flavodoxin gene was lost in the course of plant evolution, but  its reintroduction in transgenic plants confers increased tolerance to  environmental stress and iron starvation, raising the question as to why a  genetic asset with obvious adaptive value was not kept by natural selection. Phylogenetic  analyses reveal that the evolutionary history of flavodoxin is intricate, with  several horizontal gene transfer events between distant organisms, including Eukarya, Bacteria and Archaea. The  flavodoxin gene is unevenly distributed in most algal lineages, with  flavodoxin-containing species being over-represented in iron-limited regions  and scarce or absent in iron-rich environments. Evaluation of cyanobacterial  genomic and metagenomic data yielded essentially the same results, indicating  that there was little selection pressure to retain flavodoxin in iron-rich  coastal\/freshwater phototrophs. Our results show a highly dynamic evolution  pattern of flavodoxin tightly connected to the bioavailability of iron.  Evidence presented here also indicates that the high concentration of iron in  coastal and freshwater habitats may have facilitated the loss of flavodoxin in  the freshwater ancestor of modern plants during the transition of  photosynthetic organisms from the open oceans to the firm land.  ","palabras_clave":"FLAVODOXIN|FERREDOXIN|IRON|ALGAE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19796,"idioma_id":4,"titulo":"Green Light to Plant Responses to Pathogens: the Role of Chloroplast Light-Dependent Signaling in Biotic Stress","resumen":"Light has a key impact on the outcome of biotic stress responses in plants by providing most of the energy and many signals for the deployment of defensive barriers. Within this context, chloroplasts are not only the major source of energy in the light; they also host biosynthetic pathways for the production of stress hormones and secondary metabolites, as well as reactive oxygen species and other signals which modulate nuclear gene expression and plant resistance to pathogens. Environmental, and in particular, light-dependent regulation of immune responses may allow plants to anticipate and react more effectively to pathogen threats. As more information is gathered, increasingly complex models are developed to explain how light and ROS signaling could interact with endogenous defense pathways to elicit efficient protective responses against invading microorganisms. The emerging picture places chloroplasts in a key position of an intricate regulatory networkwhich involves several other cellular compartments. This article reviews current knowledge on the extent and the main features of chloroplast contribution to plant defensive strategies against biotic stress.","palabras_clave":"biotec stress|light|chloroplasts|reactive oxygen species"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19797,"idioma_id":4,"titulo":"Analysis of the hydrographic conditions and cyst beds in the San Jorge Gulf, Argentina, that favour dinoflagellate population development including toxigenic species and their toxins","resumen":"The overlay of cooler nutrient enriched Beagle?Magellan waterwithwarmer nutrient depleted shelfwater and a strong stratification of the water column in the San Jorge Gulf region, Argentina, coincided with relatively high dinoflagellate abundances in April 2012, up to 34,000 cells L&#8722;1. This dinoflagellate proliferation was dominated by Ceratium spp., but environmental conditions also favored to a lesser amount the occurrence of toxigenic dinoflagellates, such as Alexandrium tamarense and Protoceratium reticulatum, whose toxins were hardly detected in any other areas along the expedition transect of the R\/V Puerto Deseado between 38 and 56°S (Ushuaia?Mar del Plata) in March\/April 2012. Generally vegetative cells of A. tamarense and P. reticulatum co-occurred with their respective phycotoxins in the water column and their cysts in the upper sediment layers. Two strains of A. tamarense were isolated from the bloom sample and morphologically characterized. Their PSP toxin profiles consisted of C1\/2, gonyautoxins 1\/4 and to a lesser amount of neosaxitoxin and confirmed earlier data from this region. The ratios between autotrophic picoplankton and heterotrophic bacteria were higher in shelf waters in the north than in Beagle?Magellan waters in the south of San Jorge Gulf.","palabras_clave":"COASTAL WATER MASSES|SOUTHWEST ATLANTIC|PLANKTONIC COMMUNITY|TOXINS|ALEXANDRIUM TAMARENSE|PROTOCERATIUM RETICULATUM|LC-MS\/MS|DINOFLAGELLATE BLOOM|DINOFLAGELLATE CYSTS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19798,"idioma_id":4,"titulo":"Effects of salinity changes on coastal Antarctic phytoplankton physiology and assemblage composition","resumen":"A natural marine phytoplankton assemblage from a coastal environment of Antarctica was experimentally exposed to low salinity sea water (30 vs 34 in the control) during 8 days in order to study their physiological and community responses to hypoosmotic stress conditions. Hypoosmotic conditions favour water influx into the cells, which results in increased turgor pressure and increased oxidative stress. This stress is linked to a number of other cellular toxic processes, including damages to proteins, enzyme inactivation and DNA breakage. Inhibition of the instantaneous growth rate started after 48 h exposure to low salinity, but at the end of experiment, growth was significantly higher in the low than in the normal (control) salinity treatment. Hypoosmotic conditions prevented phytoplankton biomass accumulation, as evidenced by reduced Chlorophyll-a concentrations as compared to the control treatment. However, in terms of cell numbers and species composition, we observed a gradual replacement of big centric by small pennate diatoms, which became dominant by the end of the experiment. In addition, the content of reactive oxygen species (ROS) and 2-thiobarbituric acid-reactive substances (TBARS), which are indicative of oxidative stress, were studied. In the low salinity treatments, ROS concentrations were significantly higher than control values on days 4 and 6, decreasing thereafter to nearly initial values. TBARS content increased during the first 48 h and then decreased until around day 0 values. This coincided with significant increased values of the antioxidants &#945;-tocopherol and &#946;-carotene in low salinity treatments over the control. These results suggest the existence of protection mechanisms against lipid peroxidation, and lead to the conclusion that the response to stress is species-specific, so that at the community level a change in the relative abundance of phytoplankton taxa appears as a response to hypoosmotic conditions. This could have important consequences for the trophic food web dynamics in areas influenced by high fresh water inputs.","palabras_clave":"meltwater|diatoms|DCFH-DA|antarctica"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19799,"idioma_id":4,"titulo":"Oviposition in the blood-sucking insect Rhodnius prolixus is modulated by host odors","resumen":"Background: Triatomine bugs are blood-sucking insects, vectors of Chagas disease. Despite their importance, theiroviposition behavior has received relatively little attention. Some triatomines including Rhodnius prolixus stick theireggs to a substrate. It is known that mechanical cues stimulate oviposition in this species. However, it is not clear ifchemical signals play a role in this behavior. We studied the role of host cues, including host odor, in the ovipositionbehavior of the triatomine R. prolixus.Methods: Tests were carried out in an experimental arena and stimuli consisted of a mouse or hen feathers. Thenumber of eggs laid and the position of those eggs with respect to the stimulus source were recorded. Data wereanalyzed using the Mann-Whitney and Kruskal-Wallis tests.Results: Both a mouse and hen feathers stimulated oviposition. In addition, hen feathers evoked a particular spatialdistribution of eggs that was not observed in the case of mouse.Conclusions: We propose that volatile chemical cues from the host play a role in the oviposition behavior oftriatomines that stick their eggs. Thus, host odor would stimulate and spatially guide oviposition.Keywords: Oviposition stimulation, Spatial distribution of eggs, Chagas disease, Triatomine, Hematophagous insect,Insect control, Insect monitoring","palabras_clave":"TRIATOMINOS|OVIPOSITION|ODORS|CONTROL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19800,"idioma_id":4,"titulo":"Constitutive and ghrelin-dependent GHSR1a activation impair CaV2.1 and CaV2.2 currents in hypothalamic neurons","resumen":"The  growth  hormone  secretagogue  receptor  type  1a  (GHSR1a)  has  the  highest constitutive  activity  of  any  G  protein  coupled  receptor  (GPCR). GHSR1a  mediates  the action  of  the  hormone  ghrelin  and,  its  activation  increases  transcriptional  and  electrical activity  in  hypothalamic  neurons.  It  is  known  that  GHSR1a  is  present  at  GABAergic presynaptic  terminals;  however,  its  impact  on  neurotransmitter release  remains  elusive. The voltage gated calcium channels, CaV2.1 and CaV2.2, control neurotransmitter release at presynaptic terminals and their activities are modulated by many GPCRs. Here we show that constitutive as well as agonist-dependent GHSR1a activity trigger a strong impairment of  both  CaV2.1  and  CaV2.2  currents  in  rat  and  mouse  neurons  and  in  a  heterologous expression  system.  Constitutive  GHSR1a  activity  reduces  CaV2  currents  by  a  Gi\/odependent  mechanism  that  involves  persistent  reduction  in  channel  density  at  plasma membrane,  whereas,  ghrelin-dependent  GHSR1a  inhibition  is  reversible  and  involves altered  CaV2  current  gating  via  a  Gq-dependent  pathway.  Thus,  we  show  that  GHSR1a differentially  inhibits  CaV2  channels  by  Gi\/o-  or  Gq-protein  pathways  depending  on  its activation  mode.  Moreover,  we  present  evidence  suggesting  that GHSR1a-mediated inhibition of CaV2 impairs GABA release in hypothalamic neurons, a mechanism that could contribute to neuronal activation by the disinhibition of postsynaptic neurons.","palabras_clave":"ghrelin|CaV|hypotalamus|signaling"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19801,"idioma_id":4,"titulo":"Innovative Coating Method of MgAl2O4 or ZnAl2O4 on &#945;-Al2O3 Spheric Nuclei","resumen":"Structured materials composed of &#945;-Al2O3 spheres covered with a porous and thin layer of MgAl2O4 or ZnAl2O4 were obtained. The innovative coating method developed consists in the formation of a precursor gel of MgAl2O4 or ZnAl2O4 by citrate-nitrate combustion method. The alumina spheres are submerged in this gel and then submitted to a drying process in vacuum and to calcinations with N2 and N2\/O2. SEM results showed that a very rough and porous layer uniformly covers the spheres. The thickness of the layer reaches the maximum value of 16 &#956;m in the sample coated with two layers of ZnAl2O4. XRD results confirmed the MgAl2O4 or ZnAl2O4 spinel formation in the layered material. The structured materials were used as Pt catalysts supports, showing a good catalytic activity in the n-butane dehydrogenation reaction.","palabras_clave":"materials|coating|catalytic supports"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19802,"idioma_id":4,"titulo":"Insights into Pleistocene palaeoenvironments and biostratigraphy in southern Buenos Aires province (Argentina) from continental deposits","resumen":"The coastal cliffs of the Buenos Aires province (Argentina) have been the subject of intense paleontological studies since the XIX century. Therefore, many of the type localities in which is based the late Cenozoic Pampean biostratigraphic\/chronostratigraphic scheme are located in this area. In this context, the sedimentites that crop out near the mouth of the Chocorí Creek contain a set of palaeontological sites that, because of their richness and well-preserved fossil content, hold high national and international importance. The aims of the present contribution are: 1) to make a stratigraphic and sedimentological characterization of the study area; 2) to list the fauna outcropped at these palaeontological sites and establish a biostratigraphic framework; 3) to elaborate a palaeoenvironmental model for the area.        The study interval was informally subdivided into a lower, middle and upper interval. Interpretation was based on the presence of a number of key features such as architectural elements; channel:overbank ratio and palaeosol occurrence. The first two intervals were interpreted as continental deposits of a fluvio-alluvial nature and are the focus of this paper. The upper interval was related to foreshore marine deposits and will be studied in a future contribution. The lower interval is characterized mainly by overbank architectural elements in which calcisols and argillic protosols were identified. Channel-fill deposits are isolated and surrounded by fine-grained overbank successions and sedimentary structures are suggestive of mixed-load transport. The contact between the lower and middle intervals is an irregular, highly erosive surface characterized by a significant vertical change in the facies. This surface defines the base of multistorey sandbodies which´s internal arrangement alongside with the low participation of overbank deposits suggests deposition by a braided fluvial system.        Palaeosols and vertebrate fossils were used as palaeoclimatic, palaeoenvironmental and biostratigraphical proxies. Calcisol profiles, displaying Stages II to V morphologies (Machette, 1985), can be interpreted as evidence of periods of geomorphological stability that occurred under semi-arid to sub-humid climatic conditions. The occurrence of argillic Protosols stacked amongst the Calcisols evidence periods of relatively less stability, higher sediment supply and aggradation rates in the system. The vertebrate fossil assemblage and the invertebrate trace fossils also indicate semi-open landscapes under a seasonal, semi-arid climate. The presence of&nbsp;Platygonus, Glyptodon&nbsp;and&nbsp;Tolypeutes&nbsp;fossil remains in the lower interval suggest an Ensenadan age (middle Pleistocene) while the presence of&nbsp;Arctotherium bonariense&nbsp;in the V1 layer indicates post-Ensenadan (late Pleistocene) times for the middle interval.        It is concluded that during accumulation of the Chocorí succession, glacio-eustasy and\/or climate controlled the balance between generation of accommodation space and sediment supply. Analysis of the architectural elements indicates a general reduction in accommodation space. The lower interval represents the unconfined reaches of a large distributive system, more specifically, a low hierarchy, secondary drainage system inset in a high accommodation alluvial environment. The erosive surface identified at the base of the middle interval can be interpreted as representative of a period of negative accommodation in the system, when general erosion took place.The gradual restoration of accommodation in the fluvial system was accompanied by a low sediment accumulation rate and the development of a braided fluvial system in the middle interval.","palabras_clave":"PLEISTOCENE|CONTINENTAL PALAEOENVIRONMENTS|PALAEOSOLS|BIOSTRATIGRAPHY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19803,"idioma_id":4,"titulo":"A peculiar new Pampatheriidae (Mammalia: Xenarthra: Cingulata) from the Pleistocene of Argentina and comments on Pampatheriidae diversity","resumen":"Pampatheriidae are a group of cingulates native to South American that are known from themiddle Miocene to the lower Holocene. Two genera have been recognized between thelower Pleistocene and the lower Holocene: Pampatherium Gervais and Ameghino (Ensenadan,Bonaerian and Lujanian, lower Pleistocene?lower Holocene) and Holmesina Simpson(Blancan, Irvingtonian, upper Pliocene?lower Holocene). They have been mainly differentiatedby their osteoderm morphology and cranio-dental characters. These taxa had a widelatitudinal distribution, extending from the southern part of South America (Península Valdés,Argentina) to North America (Florida, USA). In this contribution, we describe a newgenus and species of Pampatheriidae for the lower and middle Pleistocene of Buenos AiresProvince and for the upper Pleistocene of Santa Fe Province (Argentina).The new taxon isrepresented by disarticulated osteoderms, one skull element, two thoracic vertebrae and aright femur and patella. It has extremely complex osteoderm ornamentations and particularmorphological characters of the cranial element and femur that are not found in any otherspecies of the family. This new taxon, recorded in the lower?middle Pleistocene (EnsenadanStage\/Age) and in the upper Pleistocene?early Holocene (Lujanian Stage\/Age), is incorporatedto the Pleistocene mammal assemblage of South America. Finally, thePampatheriidae diversity is greater during the Lujanian Stage\/Age than the EnsenadanStage\/Age.Pampatherium Gervais and Ameghino (Ensenadan,Bonaerian and Lujanian, lower Pleistocene?lower Holocene) and Holmesina Simpson(Blancan, Irvingtonian, upper Pliocene?lower Holocene). They have been mainly differentiatedby their osteoderm morphology and cranio-dental characters. These taxa had a widelatitudinal distribution, extending from the southern part of South America (Península Valdés,Argentina) to North America (Florida, USA). In this contribution, we describe a newgenus and species of Pampatheriidae for the lower and middle Pleistocene of Buenos AiresProvince and for the upper Pleistocene of Santa Fe Province (Argentina).The new taxon isrepresented by disarticulated osteoderms, one skull element, two thoracic vertebrae and aright femur and patella. It has extremely complex osteoderm ornamentations and particularmorphological characters of the cranial element and femur that are not found in any otherspecies of the family. This new taxon, recorded in the lower?middle Pleistocene (EnsenadanStage\/Age) and in the upper Pleistocene?early Holocene (Lujanian Stage\/Age), is incorporatedto the Pleistocene mammal assemblage of South America. Finally, thePampatheriidae diversity is greater during the Lujanian Stage\/Age than the EnsenadanStage\/Age.?lower Holocene) and Holmesina Simpson(Blancan, Irvingtonian, upper Pliocene?lower Holocene). They have been mainly differentiatedby their osteoderm morphology and cranio-dental characters. These taxa had a widelatitudinal distribution, extending from the southern part of South America (Península Valdés,Argentina) to North America (Florida, USA). In this contribution, we describe a newgenus and species of Pampatheriidae for the lower and middle Pleistocene of Buenos AiresProvince and for the upper Pleistocene of Santa Fe Province (Argentina).The new taxon isrepresented by disarticulated osteoderms, one skull element, two thoracic vertebrae and aright femur and patella. It has extremely complex osteoderm ornamentations and particularmorphological characters of the cranial element and femur that are not found in any otherspecies of the family. This new taxon, recorded in the lower?middle Pleistocene (EnsenadanStage\/Age) and in the upper Pleistocene?early Holocene (Lujanian Stage\/Age), is incorporatedto the Pleistocene mammal assemblage of South America. Finally, thePampatheriidae diversity is greater during the Lujanian Stage\/Age than the EnsenadanStage\/Age.?lower Holocene). They have been mainly differentiatedby their osteoderm morphology and cranio-dental characters. These taxa had a widelatitudinal distribution, extending from the southern part of South America (Península Valdés,Argentina) to North America (Florida, USA). In this contribution, we describe a newgenus and species of Pampatheriidae for the lower and middle Pleistocene of Buenos AiresProvince and for the upper Pleistocene of Santa Fe Province (Argentina).The new taxon isrepresented by disarticulated osteoderms, one skull element, two thoracic vertebrae and aright femur and patella. It has extremely complex osteoderm ornamentations and particularmorphological characters of the cranial element and femur that are not found in any otherspecies of the family. This new taxon, recorded in the lower?middle Pleistocene (EnsenadanStage\/Age) and in the upper Pleistocene?early Holocene (Lujanian Stage\/Age), is incorporatedto the Pleistocene mammal assemblage of South America. Finally, thePampatheriidae diversity is greater during the Lujanian Stage\/Age than the EnsenadanStage\/Age.?middle Pleistocene (EnsenadanStage\/Age) and in the upper Pleistocene?early Holocene (Lujanian Stage\/Age), is incorporatedto the Pleistocene mammal assemblage of South America. Finally, thePampatheriidae diversity is greater during the Lujanian Stage\/Age than the EnsenadanStage\/Age.?early Holocene (Lujanian Stage\/Age), is incorporatedto the Pleistocene mammal assemblage of South America. Finally, thePampatheriidae diversity is greater during the Lujanian Stage\/Age than the EnsenadanStage\/Age.","palabras_clave":"TONNICINCTUS|PAMPATHERIIDAE|QUATERNARY|ARGENTINE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19804,"idioma_id":4,"titulo":"Modeling nonbilinear total synchronous fluorescence data matrices with a novel adapted partial least squares method","resumen":"A new residual modeling algorithm for nonbilinear data is presented, namely unfolded partial least squares with interference modeling of non bilinear data by multivariate curve resolution by alternating least squares (U-PLS\/IMNB\/MCR-ALS). Nonbilinearity represents a challenging data structure problem to achieve analyte quantitation from second-order data in the presence of uncalibrated components. Total synchronous fluorescence spectroscopy (TSFS) generates matrices which constitute a typical example of this kind of data. Although the nonbilinear profile of the interferent can be achieved by modeling TSFS data with unfolded partial least squares with residual bilinearization (U-PLS\/RBL), an extremely large number of RBL factors has to be considered. Simulated data show that the new model can conveniently handle the studied analytical problem with better performance than PARAFAC, U-PLS\/RBL and MCR-ALS, the latter modeling the unfolded data. Besides, one example involving TSFS real matrices illustrates the ability of the new method to handle experimental data, which consists in the determination of ciprofloxacin in the presence of norfloxacin as interferent in water samples.","palabras_clave":"SECOND-ORDER ADVANTAGE|SYNCHRONOUS FLUORESCENCE|RESIDUAL MODELING|CIPROFLOXACIN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19805,"idioma_id":4,"titulo":"A demonstration of the conservation of the orbital angular momentum of the Earth","resumen":"We describe a simple but quantitative experiment to demonstrate the conservation of angular momentum. We measure the correlation of the apparent radius and angular velocity of the Sun with respect to the stars, due to the conservation of the angular momentum of Earth in its orbit. We also determine the direction of Earth?s angular momentum vector and show that it is conserved. The experiment can be performed using a small telescope and a digital camera. It is conceptually simple, allowing students to get direct physical insight from the data. The observations areperformed near the resolution limit imposed by the atmosphere, and in the presence of strong competing effects. These effects necessitate a careful experimental setup and allow students to improve their skills in experimentation.","palabras_clave":"angular momentum"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19806,"idioma_id":5,"titulo":"Liderando procesos de gestión participativa en localidades intermedias de la provincia de Santa Fe. Condiciones y desafíos en el caso de la ciudad de Firmat.","resumen":"La inclusión de herramientas de gestión participativa, por tratarse de un cambio que genera impactos en el plano interno y externo de la administración municipal, requiere de dos competencias claves: de un liderazgo que llamaremos emprendedor-relacional para que conduzca con convicción el proceso y de una estrategia de comunicación sencilla pero precisa que permita informar sobre las decisiones, convocar correctamente a la ciudadanía y conocer las inquietudes que la apertura de este tipo de procesos genera en ambos planos.  El objetivo de este artículo es abordar estas cuestiones en el  Municipio de Firmat que en 2012 comienza a incorporar herramientas de gestión participativa e impulsa la creación de dos programas: el Plan Urbano Ambiental Firmat y el Presupuesto Participativo.","palabras_clave":"Gestión Participativa|Liderazgo|Burocracia|Firmat"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19807,"idioma_id":4,"titulo":"Biological control as a strategy to reduce the impact of mycotoxins in peanuts, grapes and cereals in Argentina","resumen":"Mycotoxins including aflatoxins, deoxynivalenol, fumonisins and ochratoxin A are among the main fungal secondary metabolites detected as natural contaminants in South America in different commodities such as peanuts (aflatoxins), cereals (deoxynivalenol and fumonisins) or grapes (ochratoxin A). Different strategies including crop rotation, tillage practices, fungicide application and planting less susceptible cultivars are used in order to reduce the impact of these mycotoxins in both food and feed chains. The development of fungicide resistance in many fungal pathogens as well as rising of public concern on the risks associated with pesticide use led to the search for alternative environmentally friendly methods. Biological control of plant pathogens and toxigenic fungi offers an alternative that can complement chemical control in the frame of an integrated pest management to reduce the impact of mycotoxins in the food and feed chains. The advances made in Argentina on reducing the impact of toxigenic fungi and mycotoxins in peanut, grapes and cereals using the biocontrol strategy are summarised. Native bacteria, yeasts and filamentous fungi have been selected to evaluate them as potential biocontrol agents. Field trials showed that Bacillus subtilis RC 218 and Brevibacillus sp. RC 263 were effective at reducing deoxynivalenol accumulation in wheat. The application of Clonostachys rosea isolates on wheat stubble reduced Fusarium colonisation on the stubble. Bacillus amyloliquefaciens and Microbacterium oleovorans showed good activity to control both Fusarium verticillioides growth and the accumulation of fumonisins at pre-harvest stage in maize. Control of toxigenic Aspergillus flavus and aflatoxin accumulation in peanuts was achieved using a native atoxigenic Aspergillus flavus strain based on competitive exclusion of the toxigenic strains. Kluyveromyces thermotolerans strains were used as biocontrol agents to reduce the impact of Aspergillus section Nigri and ochratoxin A accumulation in grapes.","palabras_clave":"Aspergillus| Fusarium|biocontrol|mycotoxins"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19808,"idioma_id":4,"titulo":"Total and aboveground radiation use efficiency in C3b and C4 grass species influenced by nitrogen and water availability","resumen":"Absorbed solar radiation and radiation use efficiency (RUE) can be used to  estimate net primary productivity of terrestrial ecosystems. In ecosystems dominated  by grasses, belowground productivity cannot be neglected in terms of  carbon balance because of the high proportion of biomass allocated to roots.  The objective of this study was to quantify total RUE (tRUE), which includes  both below and aboveground biomass of two C3 (Lolium perenne and Dactylis  glomerata) and one C4 (Cynodon dactylon) grass species, under four treatments  with contrasting water and nitrogen availabilities. The ratios between tRUE and  aboveground RUE (aRUE) for species and treatments were analyzed. The tRUE  was calculated from measurements of incoming photosynthetically active radiation  (PAR), the fraction of PAR intercepted and shoots and roots productivity  in pot experiments. The highest tRUE values in the three species were found in  the treatment without growth limitations (4.32?6.93 g MJ1), while the lowest  tRUE values were observed under water and nutrient deficits conditions (2.62?  2.85 g MJ1). Contrary to predictions from the optimization theory, one of  the C3 grass species allocated relatively high biomass to the roots when water  availability was high while for the C4 grass species the shoot:root ratios and the  root mass fraction did not change under resource limitation conditions compared  to ample resource availability. tRUE exhibited small changes in the C4  species with variations in resource availability while it did decrease substantially  for the C3 species when at least one of the resources was limited. These results  highlight belowground biomass importance in calculating RUE of grasses.","palabras_clave":"Cynodon dactylon|Dactylis glomerata|Lolium perenne|roots"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19809,"idioma_id":5,"titulo":"Adicción al tabaco, Percepción de Riesgos y Ley Antitabáquica- Diferencias Regionales","resumen":"En este documento se presentan los resultados iniciales de una investigación que busca realizar un análisis económico de la problemática del tabaquismo en Argentina. Se examina la presencia de desigualdades socioeconómicas en el consumo de tabaco utilizando la razón de grupos extremos y el índice de concentración. Los resultados indican diferencias tanto por género como por región geográfica. Ambos índices muestran concentración del consumo en los estratos más vulnerables de la sociedad. La teoría de la adicción racional en contexto de incertidumbre, que sirve de sustento teórico a esta investigación, predice que la percepción de riesgo de los individuos es uno de los  determinantes de la decisión de consumo de los individuos cuando se trata de bienes que generan adicción. Los resultados econométricos obtenidos muestran que las percepciones subjetivas de riesgo influyen significativamente, en términos estadísticos, en la decisión de fumar. Se avanza, luego, en el análisis de los efectos de la normativa antitabáquica en Argentina, explotando la entrada en vigencia de distintas leyes provinciales en momentos temporales diferentes. Se utilizan métodos cuantitativos de evaluación de impacto. Cuando se comparan las variables cantidad de fumadores y número de cigarrillos consumidos, antes y después de la implementación de la ley se observa que en las provincias tratadas disminuyó la prevalencia de fumadores y el consumo de cigarrillos mientras que aumentó la prevalencia de ex fumadores. Sin embargo, al avanzar en otros indicadores como ATE (average treatment effect) y DD (differeces in difference), los resultados no son contundentes. JEL: I14, I18, D12.","palabras_clave":"FUMADOR|FACTORES SOCIOECONÓMICOS|SALUD|REGIONAL"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19810,"idioma_id":4,"titulo":"Low contrast buried waveguides index profile  reconstruction method considering the evanescent field","resumen":"In this work wepresent a new approach related to the profile reconstruction of graded-indexwaveguides, based on the inversion of the Helmholtz equation for TE propagationmodes from measuring the near field. We used the scalar approximation but wealso consider the evanescent field as key experimental data to be acquired andanalyzed. From this, it is possible to obtain a better fitting of the real lowcontrast waveguides index profile, and get more important information allowingus to determine at the same time the effective index and the shape of theguidance cross-section.Comparedwith experimental data, it could be possible, in a self-consistent way, toenhance the accuracy of the retrieval&nbsp;&nbsp;information corresponding to the transversal shape of these kinds ofwaveguides. This procedure also allows us to obtain an effective and absoluterefractive index profile, instead of the relative determinations that areusually reported in the literature.","palabras_clave":"refractive index reconstruction|written waveguides|Hemholtz equation|effective index"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19811,"idioma_id":4,"titulo":"Towards sustainable maize production: Glyphosate detoxification by Azospirillum sp. and Pseudomonas sp.","resumen":"To contribute to more sustainable crop production, this study evaluated the capacity of Azospirillum sp.and Pseudomonas sp. to degrade glyphosate residues both in vitro and in vivo in maize plants (Zea mays L.)at different growth stages. In vitro, both bacteria tolerated glyphosate and were capable of using it as acarbon source. In bioassays, inoculation with both bacteria improved germination and root emergence,primary root growth, root hair development and coleoptile growth in seeds previously treated with theherbicide. Foliar inoculation with Azospirillum sp. and Pseudomonas sp. in glyphosate-treated plantsimproved root and shoot biomass and increased foliar area, photosynthetic pigments and phytohormonecontent as well, thus increasing maize yield in the field while concomitantly decreasing herbicideaccumulation in leaves and grains. The bacterial capacity to degrade glyphosate in vivo at differentgrowth stages in maize plants growing in the field is a novel and promising biotechnological technique tominimize the persistence of xenobiotic compounds in the environment. This finding adds to the alreadyknown importance of the application of bacterial inoculants to crops to enhance plant growth, developmentand yield.","palabras_clave":"PLANT GROWTH PROMOTING RHIZOBACTERIA|CROP QUALITY|FOLIAR APPLICATIONS|AGROCHEMICAL TOXICITY|RR MAIZE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19812,"idioma_id":4,"titulo":"New records of seven species of pholcid spiders (Araneae,  Pholcidae) from the northern Argentina","resumen":"We report new record of pholcid species for northern Argentina. Guaranita yaculica Huber, 2000 and Mesabolivar uruguayensis Machado Laborda, Simó & Brescovit, 2013 are reported for the first time for Corrientes province, whereas Aymaria calilegua Huber, 2000 and Nerudia atacama Huber, 2000 are for the first time reported for Salta province. The last corresponds to a new record for Argentina. We also expand the known distribution of Guaranita goloboffi Huber, 2000, Chibchea salta Huber, 2000, and Pholcus phalangioides (Fuesslin, 1775) for Salta province.","palabras_clave":"NEW RECORDS|SPIDERS|PHOLCIDAE|NORTHERN"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19813,"idioma_id":4,"titulo":"The mitochondrial DNA history of a former native American village in northern Uruguay","resumen":"  Objectives    In 1828, between 8,000 and 15,000 Indians from the Jesuit Missions were brought to Uruguay. There, they were settled in a village, presently named Bella Unión, in the northwest corner of the country. According to historic sources, the Indians abandoned the settlement shortly thereafter, with the village subsequently repopulated by ?criollos? and immigrants from abroad. As a first approach to reconstruct the genetic history of the population, data about the living population genetic structure will be used. Based on the analysis of the maternal lineages of the inhabitants of Bella Unión, and of those from two nearby villages, we expect to partially answer what happened with the first and subsequent inhabitants.    Methods    We analyzed the maternal lineages of the present inhabitants of Bella Unión and neighboring localities through the sequencing of the mitochondrial DNA control region.    Results    A total of 64.3%, 5.7%, and 30% of the mtDNAs were of Native, African, and West Eurasian origin, respectively. These figures are quite similar to that of the population of Tacuarembó, which is located in northeastern Uruguay. The four main Native American founding haplogroups were detected, with B2 being the most frequent, while some rare subhaplogroups (B2h, C1b2, D1f1) were also found. When compared with other Native American sequences, near- matches most consistently pointed to an Amazonian Indian origin which, when considered with historical evidence, suggested a probable Guaraní-Missionary-related origin.    Conclusions    The data support the existence of a relationship between the historic and present inhabitants of the extreme northwest Uruguay, with a strong contribution of Native Americans to the mitochondrial DNA diversity observed there.","palabras_clave":"MITOCHONDRIAL DNA|HAPLOTYPES|HAPLOGROUPS|NATIVE AMERICAN|ADMIXTURE|URUGUAY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19814,"idioma_id":4,"titulo":"THE EFFECT OF A HYDROGEN SULFIDE RELEASING MOLECULE (NA2S) ON THE COLD STORAGE OF LIVERS FROM CARDIAC  DEAD DONOR RATS. A STUDY IN AN EX VIVO MODEL","resumen":"Liver transplantation is currently the preferred treatment option for end-stage liver disease. Donation after cardiac death was a common practice in the early years of organ donation before brain death criteria were established. Those organs were subjected to variable periods of warm ischemia that might intensify cold ischemia\/reperfusion injuries. In the present, shortage of brain dead donors has led to the reassessment of organ donation after cardiac death. Since many cytoprotective roles have been describe for H2S during ischemia\/reperfusion on a variety of tissues, we hypothesized that graft exposure to this bioactive gas might improve preservation of non-heart beating donated organs.Therefore, to establish a rat model of donation post-cardiac arrest and using this approach to judge H2S delivery effects on graft hypothermic preservation, were the main objectives of this investigation. Cardiopulmonary arrest was induced in sedated rats by overload of potassium (K+). Livers were surgically removed and subsequently stored in HTK Solution (Histidine-tryptophan-ketoglutarate) at 0-4 ºC.After 24 h of hypothermic preservation, livers were rewarmed in an ex vivo model. Three experimental groups were established as follows: I - Livers procured before cardiac death and cold stored 24 h in HTK (BCD); II - Livers procured after cardiac death (45 min) and cold stored 24 h in HTK (ACD); III - Livers procured after cardiac death (45 min) and cold stored 24 h in HTK + 10 uM Sodium Sulfide (Na2S) (ACD-SS). Data suggest that after 45 min of warm ischemia, viability parameters assessed during reperfusion in the ex vivo model were significantly impaired. Real time PCR revealed that after ex vivo reperfusion there is an increased expression of HO-1 and TNF-a and a modest drop in Bcl-2 mRNA, which could be interpreted as the cellular response to the hypoxic insult sustained during warm ischemia.On the other hand, warm ischemic livers exposed to H2S during cold storage, improved microcirculation, morphology and viability parameters during ex vivo reperfusion and showed significant modulation of HO-1 mRNA expression.In conclusion, HTK supplementationwith Na2S arose as a potential treatment to recover non-heart beating harvested organs. Furthermore, an appropriate model of cardiac dead liver donors was successfully developed.","palabras_clave":"COLD STORAGE |HYDROGEN SULFIDE |GASEOUS TRANSMITTER|DONATION AFTER CARDIAC DEATH"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19815,"idioma_id":4,"titulo":"Corrosion behavior of Zinc or 55%Al-Zn hot-dip coated steel in 0.5 m NaCl solution","resumen":"A comparative study on the anticorrosive behaviour of 55%Aluminum-Zincalloy  and Zinc hot-dip coated carbon steel immersed in 0.5 mol\/L NaCl  solution was performed using DC (polarization curves) and AC  (electrochemical impedance spectroscopy) techniques. Also, the corrosion  products formed under these testing conditions were characterized using  XRD, SEM and EDS. The experimental results showed that the corrosion  resistance of the 55%Al-Zn alloy coating showed a synergistic effect being  more satisfactory than the each metal used separately and the Zn tested  coating. This was attributed to the effectiveness of two forms of protection:  the cathodic protection and the barrier effect (afforded by a basic zincaluminumcarbonate  layer) acting together. Themorphological characteristics  of their corrosion products also differed.","palabras_clave":"CINCALUM|GALVANIZED|CORROSION|COATINGS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19816,"idioma_id":4,"titulo":"Corrosion of painted galvanneal steel","resumen":"The annealing galvanized steel (Galvanneal) is produced from hot-dip galvanized steel thermally treated. The result is a coatingformed by Fe-Zn phases. Its main advantage over the conventional galvanized steel is the absence of the characteristic spanglesaffecting these coatings and the presence of iron providing better weldability than the pure zinc coating. In this work, thecorrosion behavior of pre-treated and painted with environmentally friendly schemes, conventionally hot-dip galvanized, andannealing galvanized (Galvanneal) steel were studied. A &#1048650;-mercaptopropyltrimethoxysilane (MTMO) pre-treatment was applied.A waterborne polyurethane paint developed at CIDEPINT was used. Assays were performed in the salt spray and controlledhumidity chambers. The metal-paint adhesion was determined by Tape Test. The systems deterioration was evaluated by meansof periodical visual inspections, optic and electron microscopes, EDXS, and electrochemical impedance measurements. TheMTMO showed to be a good adhesion promoter for the systems exposed to the present testing conditions.","palabras_clave":"GALVANNEAL|GALVANIZED STEEL|CORROSION|PAINT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19817,"idioma_id":4,"titulo":"Negative and positive interactions among plants: effect of competitors and litter on seedling emergence and growth of forest and grassland species","resumen":"Living plant neighbours, but also their dead aboveground remains (i.e. litter), may individually exert negative or positive effects on plant recruitment. Although living plants and litter co-occur in most ecosystems, few studies have addressed their combined effects, and conclusions are ambivalent. Therefore, we examined the response in terms of seedling emergence and growth of herbaceous grassland and forest species to different litter types and amounts and the presence of competitors. We conducted a pot experiment testing the effects of litter type (grass, oak), litter amount (low, medium, high) and interspecific competition (presence or absence of four Festuca arundinacea individuals) on seedling emergence and biomass of four congeneric pairs of hemicryptophytes from two habitat types (woodland, grassland). Interactions between litter and competition were weak. Litter presence increased competitor biomass. It also had positive effects on seedling emergence at low litter amounts and negative effects at high litter amounts, while competition had no effect on seedling emergence. Seedling biomass was negatively affected by the presence of competitors, and this effect was stronger in combination with high amounts of litter. Litter affected seedling emergence while competition determined the biomass of the emerged individuals, both affecting early stages of seedling recruitment. High litter accumulation also reduced seedling biomass, but this effect seemed to be additive to competitor effects. This suggests that live and dead plant mass can affect species recruitment in natural systems, but the mechanisms by which they operate and their timing differ.","palabras_clave":"Campanula|competition|facilitation|Galium|germination|oak (Quercus robur L.)|plant recruitment|plantplant interactions|Poa|Rumex|seedling biomass|seedling emergence"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19818,"idioma_id":4,"titulo":"Ants at the edge: a sharp forest-steppe boundary influences the taxonomic and functional organization of ant species assemblages along elevational gradients in northwestern Patagonia (Argentina)","resumen":"Biogeographic transitions may play a significant role in generating unique biodiversity patterns along different spatial dimensions of the geobiosphere. The extent, however, to which the presence of large-scale biogeographic transitions interacts with local environmental variation to account for elevational patterns in species diversity still remains elusive. To address this issue, we analysed the association of local variation in environmental variables (temperature, precipitation, vegetation cover, plant species richness and soil conditions) with the taxonomic and functional structuring of ant species assemblages on five elevation gradients across a well-established biogeographic transition between Subantarctic forests and high-Andean steppes in north-western Patagonia (Argentina). Data on the presence\/absence of 15 ant species were obtained from 486 pitfall traps arranged in fifty-four 100 m2 grid plots of nine traps, established at intervals of approximately 100 m elevation, measured from the base to the summit of each mountain. The elevational replacement of lowland shrublands and forests by stunted forests and high Andean steppes was associated with a decrease in species richness; minimum richness (or even absence of ants on some mountains) was recorded at intermediate elevations. Ant richness decreased as temperature decreased and as tree canopy cover increased; however, temperature was the strongest predictor of richness. About 13.8 % of elevational variation in richness was accounted for by temperature, independently of tree canopy cover and macrohabitats; another 18.9 % was accounted for by the shared effects of temperature and macrohabitats. The presence of some species was associated with lowland shrublands and forests but the high Andean steppes were inhabited mainly by ubiquitous species, i.e. widespread species whose presence was recorded in all macrohabitats. We concluded that the transition between the Subantarctic forests and high Andean steppes represents a sharp barrier to ant species? elevational distribution. This, in association with elevational variation in continuous environmental functions, mainly temperature, influences the richness and taxonomic and functional structuring of ant species assemblages at temperate latitudes of the southern hemisphere.","palabras_clave":"BIOGEOGRAPHICAL TRANSITION|FORMICIDAE|FUNCTIONAL DIVERSITY|HIGH ANDEAN STEPPES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19819,"idioma_id":4,"titulo":"Structure, thermodynamic properties, and phase diagrams of few colloids confined in a spherical pore","resumen":"We study a system of few colloids confined in a small spherical cavity   with event driven molecular dynamics simulations in the canonical   ensemble. The colloidal particles interact through a short range   square-well potential, that takes into account the basic elements of   attraction and excluded-volume repulsion of the interaction among   colloids. We analyze the structural and thermodynamic properties of this   few-body confined system in the framework of inhomogeneous fluids   theory. Pair correlation function and density profile are used to   determine the structure and the spatial characteristics of the system.   Pressure on the walls, internal energy and surface quantities such as   surface tension and adsorption are also analyzed for a wide range of   densities and temperatures. We have characterized systems from 2 to 6   confined particles, identifying distinctive qualitative behavior over   the thermodynamic plane T-&#961;, in a few-particle equivalent to phase   diagrams of macroscopic systems. Applying the extended law of   corresponding states the square well interaction is mapped to the   Asakura-Oosawa model for colloid-polymer mixtures. We link explicitly   the temperature of the confined square-well fluid to the equivalent   packing fraction of polymers in the Asakura-Oosawa model. Using this   approach we study the confined system of few colloids in a   colloid-polymer mixture.","palabras_clave":"Colloids |Confined Fluids |Square Well|Molecular Dynamics"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19820,"idioma_id":4,"titulo":"Pigment-dispersing factor (Pdf) signaling in the circadian system of Caenorhabditis elegans","resumen":"The neuropeptide pigment-dispersing factor (PDF) is important for the generation and entrainment of circadian rhythms in the fruitfly Drosophila melanogaster. Recently two pdf homologs, pdf-1 and pdf-2, and a PDF receptor, pdfr-1, have been found in Caenorhabditis elegans and have been implicated in locomotor activity. In this work, we have studied the role of the PDF neuropeptide in the circadian system of C. elegans and found that both pdf-1 and pdf-2 mutants affect the normal locomotor activity outputs. In particular, loss of pdf-1 induced circadian arrhythmicity under both light-dark (LD) and constant dark (DD) conditions. These defects can be rescued by a genomic copy of the pdf-1 locus. Our results indicate that PDF-1 is involved in rhythm generation and in the synchronization to LD cycles, as rhythmic patterns of activity rapidly disappear when pdf-1 mutants are recorded under both entrained and free-running conditions. The role of PDF-2 and the PDF receptors is probably more complex and involves the interaction between the two pdf paralogues found in the nematode.","palabras_clave":"CIRCADIAN RHYTHMS|CAENORHABDITIS ELEGANS|PDF|NEUROPEPTIDE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19821,"idioma_id":4,"titulo":"Non-native species litter reduces germination and growth of resident forbs and grasses: allelopathic, osmotic or mechanical effects?","resumen":"Non-native plant species may contain allelopathic substances that might help to out-compete native vegetation. These allelochemicals may be  released from live or dead plant tissues and be accumulated in the soil. We tested whether non-native species leaf litter and their leachates reduced seedling establishment and growth of native species. We subjected seeds of six native species to the effect of litter leachates of three of the most important invasive plants in Europe and to mannitol solutions with similar osmotic potential in germination chamber experiments. Additionally, we measured the effect of the same litter on emergence and growth of the native species in an outdoor pot experiment. Litter leachates delayed and reduced germination and affected initial root growth of all native species. The effects of leachates were signi&#64257;cantly higher than those of mannitol, indicating the action of toxic, most probably allelochemical substances. Emergence of seedlings in pots was also reduced, but total biomass per pot was not affected and biomass per seedling increased. Allelochemicals may affect germination and early  stages of seedling recruitment. However, these negative effects seem to cease shortly after germination, when other mechanisms such as competition may be more important. Consequently, litter-borne allelochemicals are unlikely to drive the invasion of the studied non-native species, but they may contribute to maintain mono-dominant stands reinforcing invasion success.","palabras_clave":"Allelochemichals|Grassland|Litter leachates"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19822,"idioma_id":4,"titulo":"'Inhibitory effect of natural phenolic compounds on Aspergillus parasiticus growth'","resumen":"as well as to eliminate or reduce their presence in food products. For this reason, the aims of this investigation were to evaluatethe effects of ten natural phenolic compounds on the Aspergillus parasiticus growth and to determine which physicochemicalproperties are involved in the antifungal activity. According to the results of minimum inhibitory concentration (MIC) valuesof the individual compounds, isoeugenol, carvacrol, and thymol were the most active phenolic components (1.26 mM, 1.47mM,and 1.50mM, resp.), followed by eugenol (2.23mM). On the other hand, creosol, p-cresol, o-cresol, m-cresol, vanillin, and phenolhad no effects on fungal development. Logarithm of the octanol\/water partition coefficient (log P), refractivity index (RI), andmolar volume (MV) were demonstrated to be the descriptors that best explained the antifungal activity correlated to lipophilicity,reactivity of the components, and steric aspect. These findings make an important contribution to the search for new compoundswith antifungal activity.","palabras_clave":"Natural Phenolic|Asoergillus parasiticus|Growth"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19823,"idioma_id":4,"titulo":"Potentiation of the effect of a commercial animal feed additive mixed with different probiotic yeast strains on the adsorption of aflatoxin B1","resumen":"This study potentiates the adsorbent effect for aflatoxin B1 (AFB1) of a commercial additive (CA) of animal feed,  containing inactive lysate of three Saccharomyces cerevisiae strains, active enzymes, adsorbents and a selenium?amino  acid complex, when the additive was mixed separately with three S. cerevisiae strains. Levels of AFB1 of 20 and 50 ng g&#8722;1  were used to determine the binding capacity of different concentrations of CA alone and in the presence of yeast strains, as  well as toxin desorption, under gastrointestinal conditions. The viability of yeasts in the presence of CA was evaluated. The  results show that the CA did not affect the viability of the yeast strains assayed. CA alone showed a low percentage  adsorption. At 20 and at 50 ng g&#8722;1, CA was highly efficient in adsorbing AFB1 when combined with RC016 and RC012  strains respectively. Desorption of AFB1 by CA alone and in combination with the yeasts increased with increasing levels of  CA. The results demonstrate the improvement of CA in AFB1 adsorption once it is mixed with live yeasts.","palabras_clave":"ANIMAL FEED|ADDITIVE MIXED|PROBIOTIC YEAST|AFLATOXIN B1"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19824,"idioma_id":5,"titulo":"Llamados a ser protagonistas. Política educativa, movilización juvenil y participación de los estudiantes secundarios en la Argentina. Provincia de Buenos Aires. 2009-2014","resumen":"            A partir de un conjunto de hallazgos empíricos  y conceptuales -producto de una investigación finalizada-, en este trabajo  buscamos dar cuenta de las características que asume la participación política  de los estudiantes secundarios en el ámbito escolar y en las organizaciones del  movimiento estudiantil. Para ello, analizamos y ponemos en relación dichas  características con los cambios recientes en la política educativa provincial,  sus efectos y múltiples apropiaciones por parte de los actores involucrados:  directivos, estudiantes y militantes. Sugerimos entonces que los cambios en la  política tienen vínculos complejos y multidimensionales con las organizaciones  políticas en un contexto de reconfiguraciones de la militancia juvenil. Arriesgamos que dicha confluencia ha impactado en una importante revitalización  de la participación escolar y de la conformación de organizaciones  estudiantiles, tanto partidarias como independientes. Consideramos que este  trabajo puede enriquecer las reflexiones en torno a la relación entre políticas educativas, escuelas y acción  colectiva. Por último, en un contexto regional donde la literatura enfatiza la  movilización estudiantil a partir de características confrontativas con el  Estado y las formas institucionales de representación política, el caso argentino  nos permite mostrar y reflexionar sobre otras articulaciones posibles entre  estas instancias y la participación política juvenil.              Indexaciones: EBSCOhost ; SCOPUS, ERIC&nbsp; Cabell´s  Directories; CAPES\/Qualis A2 (Brazil); Scimago Journal Ranking; CIRC,  Clasificación Integrada de Revistas Científicas, (Spain); DIALNET (Spain);  Directory of Open Access Journals; Education Research Exercise list of  Journals, Australia 1\/1\/2006-;&nbsp; Education  Research Global Observatory; HEAL Link; H.W. Wilson; PubMed;&nbsp; Educational Research Abstracts Online;  Research into Higher Education Abstracts (Online); Ulrich´s Periodicals  Directory; REDALyC, 2005; Elektronische Zeitschriftenbibliothek - Frei  zugängliche E-Journals            ","palabras_clave":"MOVIMIENTO|ESTUDIANTIL|POLITICAS|EDUCATIVAS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19825,"idioma_id":4,"titulo":"Gold-palladium core@shell nanoalloys: experiments and simulations","resumen":"In this work, we report a facile synthesis route, structural characterization, and full atomistic simulations of gold?palladium nanoalloys. Through aberration corrected-STEM, UV-vis spectroscopy and EDS chemical analysis, we were able to determine that Au(core)?Pd(shell) bimetallic nanoparticles were formed. Using different computational approaches, we were capable of establishing how the size of the core and the thickness of the shell will affect the thermodynamic stability of several core?shell nanoalloys. Finally, grand canonical simulations using different sampling procedures were used to study the growth mechanism of Pd atoms on Au seeds of different shapes.","palabras_clave":"Au-Pd NANOPARTICLES|CORE-SHELL|NANOALLOYS |GRAND CANONICAL| LANGEVIN DYNAMICS|STEM|EDS."},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19826,"idioma_id":4,"titulo":"Bounds for axially symmetric linear perturbations for the extreme  Kerr black hole","resumen":"We obtain remarkably simple integral bounds for axially symmetric linear perturbations for the extreme Kerr black hole in terms of conserved energies. From these estimates we deduce pointwise bounds for the perturbations out side the horizon.","palabras_clave":"Black holes|extreme|lineal stability|non modal"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19827,"idioma_id":4,"titulo":"In-situ DRIFT study of Au-Ir\/ceria catalysts: activity and stability for CO oxidation","resumen":"                  Monometallic gold and iridium, and bimetallic  gold-iridium on ceria catalysts were synthesized by deposition-precipitation  with urea. The activity of these ceria supported catalysts for CO oxidation  was: Au-Ir &gt;&gt; Au &gt; Ir. The bimetallic catalyst was highly active and  stable during the carbon monoxide oxidation reaction, showing synergism between  both metals. The catalysts were thoroughly characterized chemical and  structurally. High-resolution electron microscopy coupled with energy  dispersive spectroscopy and X-ray photoelectron spectroscopy showed evidences  of iridium-gold intimacy. In situ infrared spectroscopy in the diffuse  reflectance (DRIFT) mode was used to investigate the reactivity of the active  sites. Concentration-modulation excitation spectroscopy (c-MES) allowed  selective identification of intermediates and ?spectator? species. CO  chemisorbed onto iridium sites (2096, 2060 and 2012 cm-1) was found  inactive, whereas carbon monoxide on metallic gold sites (Au0-CO,  2110 cm-1) exhibited reactivity for CO oxidation. In the bimetallic  catalyst, new active sites (Aud--CO, 2095 and  2026 cm-1) together with Au0-CO species were observed,  most likely produced by the isolation and stabilization of gold atoms by iridium.  ","palabras_clave":"CO oxidation|Gold; Iridiun; Ceria|DRIFT|Modulation excitation spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19828,"idioma_id":4,"titulo":"The effect of sunlight interception by sooty mold on chlorophyll content and photosynthesis in orange leaves (Citrus sinensis L.)","resumen":"Abstract   Sooty molds are a lineage of follicolous fungi  that cover the upper surface of leaves with black  mycelia. Sooty molds do not infect plants, but grow on  surfaceswhere honeydewdeposits accumulate. It causes  a reduction of incident sunlight by physical obstruction  and in some species it interferes with photosynthesis.  However, there are no studies proving that light inter-  ception by the sooty mold mycelia affects photosynthe-  sis in orange plants. The aim of this study was to  experimentally evaluate changes in the interception of  sunlight caused by the black coating of sooty mold  formed on orange leaves and to investigate its effects  on the leaf chlorophyll content, stomatal conductance  and photosynthetic rate. To facilitate the measurements,  orange leaves with and without sooty mold colonies  were selected. On a clear day, the sooty mold mycelia  intercepted between 44 and 74 % of the total incident  photosynthetic photon flux density (PPFD). However,  even on leaves covered by the sooty mold mycelia, the  measured PPFD was sufficient to saturate maximum net  photosynthesis rate (Amax) for much of the day. No  differences were found in Amax or leaf conductance,  but there were increases in chlorophyll content and  quantum yield in leaves infested by sooty mold, reveal-  ing a clear acclimation response. This study is the first to  experimentally assess the direct effects of sunlight inter-  ception by sooty mold on chlorophyll content and net  photosynthesis in orange leaves.","palabras_clave":"Sooty mold|Sunlight interception|chlorophyll|photosynthesis"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19829,"idioma_id":4,"titulo":"Upstream proton cyclotron waves at Venus near solar maximum","resumen":"magnetometer data of Venus Express are analyzed for the occurrence of waves at the proton cyclotron frequency in the spacecraft frame in the upstream region of Venus, for conditions of rising solar activity. The data of two Venus years up to the time of highest sunspot number so far (1 Mar 2011 to 31 May 2012) are studied to reveal the properties of the waves and the interplanetary magnetic field (IMF) conditions under which they are observed. In general, waves generated by newborn protons from exospheric hydrogen are observed under quasi- (anti)parallel conditions of the IMF and the solar wind velocity, as is expected from theoretical models. The present study near solar maximum finds significantly more waves than a previous study for solar minimum, with an asymmetry in the wave occurrence, i.e., mainly under antiparallel conditions. The plasma data from the Analyzer of Space Plasmas and Energetic Atoms instrument aboard Venus Express enable analysis of the background solar wind conditions. The prevalence of waves for IMF in direction toward the Sun is related to the stronger southward tilt of the heliospheric current sheet for the rising phase of Solar Cycle 24, i.e., the 'bashful ballerina' is responsible for asymmetric background solar wind conditions. The increase of the number of wave occurrences may be explained by a significant increase in the relative density of planetary protons with respect to the solar wind background. An exceptionally low solar wind proton density is observed during the rising phase of Solar Cycle 24. At the same time, higher EUV increases the ionization in the Venus exosphere, resulting in higher supply of energy from a higher number of newborn protons to the wave. We conclude that in addition to quasi- (anti)parallel conditions of the IMF and the solar wind velocity direction, the higher relative density of Venus exospheric protons with respect to the background solar wind proton density is the key parameter for the higher number of observable proton cyclotron waves near solar maximum.","palabras_clave":"UPSTREAM WAVES|VENUS|PROTON CYCLOTRON WAVES|SOLAR MAXIMUM"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19830,"idioma_id":4,"titulo":". First isolation of  Bunyamwera virus ((Bunyaviridae family) from horses with neurological disease and an abortion in Argentina","resumen":"Bunyamwera virus (BUNV) is the prototype virus for both the Orthobunyavirus genus and the Bunyaviridae family. Different strains of BUNV have been associated with clinical diseases in domestic animals, mainly ruminants. During 2013, in Argentina´s Santa Fe Province, three new isolates of BUNV were recovered from the brain and spleen of two horses with encephalitis, and from the brain of an aborted equine fetus. This isolation of BUNV from domestic animals provided the first association of BUNV infection with disease of the central nervous system and abortion in equines in Argentina.","palabras_clave":"Bunyamwera|Orthobunyavirus|starins|horses"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19831,"idioma_id":4,"titulo":"Fusarium temperatum and Fusarium subglutinans isolated from maize in Argentina","resumen":"Fusarium temperatum and Fusarium subglutinans isolated from the Northwest region (NOA region) of Argentina were characterized using a polyphasic approach based on morphological, biological and molecular markers. Some interfertility between the species was observed. The phylogenetic analysis showed that the two species represented two clades strongly supported by bootstrap values. The toxigenic profile of the strains was also determined. F. temperatum strains were fusaproliferin and beauvericin producers, and only some strains were fumonisin B1 producers. All F. subglutinans strains produced fusaproliferin but none produced beauvericin, indicating a potential toxicological risk from maize harvested in the NOA region of Argentina. This study provides new information about F. temperatum isolated from maize in Argentina.","palabras_clave":"FUSARIUM TEMPERATUM|FUSARIUM SUBGLUTINANS|MAIZE|BAEAUVERICIN|FUSAPROLIFERIN|FUMONISINS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19832,"idioma_id":4,"titulo":"Occurrence of antilisterial structural bacteriocins genes in meat borne lactic acid bacteria","resumen":"The ability to inhibit the growth of Listeria cells and the   presence of bacteriocin encoding genes was examined in 115 LAB strains   isolated from Argentinean vacuum-packaged beef and different traditional   fermented sausages. Lactobacillus (L) sakei, Lactobacillus (L) curvatus and Enterococcus (E) faecium showed a great inhibition of all Listeria strains evaluated while Pediococcus (P) acidilactici and Lactobacillus (L) plantarum demonstrated a limited or absent antilisterial activity. Both L. curvatus and L. sakei carried the sppA, sppQ and sapA structural genes, encoding for sakacin P, sakacin Q and curvacin A bacteriocins, respectively. Whilst L.&nbsp;curvatus exhibited a higher occurrence of these genes, L.&nbsp;sakei strains were more effective at inhibiting Listeria (L) strains, Listeria monocytogenes UC8159 and Listeria innocua 7 being the most sensitive to these bacteriocins. Among analyzed E. faecium strains, the wide distribution of entA, entB and entP genes accounted for the high antilisterial activity particularly observed against L. monocytogenes FBUNT. The structural gene plantEF was mostly present in Lactobacillus plantarum strains and no pedA gene was found in P. acidilactici evaluated strains. The antilisterial potential of L.&nbsp;sakei and E.&nbsp;faecium   offers great possibilities for the meat industry as biopreservative   cultures, although more studies are needed in order to conclude about   this issue.","palabras_clave":"Bactgerias lácticas|genes de bacteriocinas|productos cárneos"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19833,"idioma_id":4,"titulo":"Autochthonous starter culture selection to keep traditions in the manufacture of dry sausages alive","resumen":"Abstract Lactic acid bacteria (LAB) and non-pathogenic  staphylococci from naturally fermented sausages  manufactured in northeastern Argentina were isolated and  selected on the basis of physiological, technological, and  safety properties. Eighty-seven isolates recovered from four  small-scale facilities were studied to evaluate growth and  acidification kinetics, nitrate-reductase, proteolytic, lipolytic,  decarboxylase, and antagonistic activities, as well as growth  ability at different temperatures, pH, and NaCl concentrations.  Based on these characteristics as well as antibiotic resistance  for CNC isolates, a selection and identification by sequencing  the 16S rRNA gene was carried out. As a result, LAB isolates  were identified as Lactobacillus sakei (seven isolates) and  Lactobacillus farciminis (one isolate), while CNC revealed  isolates as being Staphylococcus xylosus (two isolates),  Staphylococcus vitulinus (one isolate), and Staphylococcus  hominis (one isolate). Properties exhibited by selected isolates  would make them eligible as starter cultures to enhance both  sensorial and safety qualities of artisanal fermented sausages  while keeping manufacturing traditions.","palabras_clave":"DRY FERMENTED SAUSAGE|LACTIC ACID BACTERIA|COAGULASE NEGATIVE COCCI|STARTERS CULTURES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19834,"idioma_id":4,"titulo":"Low molecular weight peptides derived from sarcoplasmic proteins produced by an autochthonous starter culture in a beaker sausage model: a peptidomic approach","resumen":"tThis study focuses on meat protein degradation by different starter cultures. Sausage modelsinoculated with Lactobacillus curvatus CRL705 and Staphylococcus vitulinus GV318 alone and asa mixture were incubated 10 days at 22&#9702;C. Low molecular weight peptides (<3 kDa) derivedfrom sarcoplasmic proteins were analyzed by a peptidomic approach. A diverse number ofprotein fragments were identified. The greatest peptides diversity was obtained when themixed starter culture was present. Peptides mainly arose from myoglobin, creatine-kinase,glyceraldehyde-3-phosphate-dehydrogenase and fructose-biphosphate-aldolase (ALDOA).ALDOA hydrolysis was attributed to the mixed starter culture; the released peptides couldact as biomarkers for a specific sausage technology.Significance: The selection of a specific autochthonous starter culture guarantees the hygieneand typicity of fermented sausages. The identification of new peptides as well as new targetproteins by means of peptidomics represents a significant step toward the elucidation ofthe role of microorganisms in meat proteolysis. Moreover, these peptides may be furtherused as biomarkers capable to certify the use of the applied autochthonous starter culturedescribed here.","palabras_clave":"Meat proteolysis|Lactic Acid Bacteria|Starter cultures|Peptidomic"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19835,"idioma_id":4,"titulo":"Activation of PI3K\/Akt\/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast  tumor regression","resumen":"Improved efficacy of neoadjuvant endocrine-targeting therapies in luminal breastcarcinomas could be achieved with optimal use of pathway targeting agents. In amouse model of ductal breast carcinoma we identify a tumor regressive stromalreaction that is induced by neoadjuvant endocrine therapy. This reparative reaction is characterized by tumor neovascularization accompanied by infiltration of immune cells and carcinoma-associated fibroblasts that stain for phosphorylated ribosomal protein S6 (pS6), downstream the PI3K\/Akt\/mTOR pathway. While tumor variants with higher PI3K\/Akt\/mTOR activity respond well to a combination of endocrine and PI3K\/Akt\/mTOR inhibitors, tumor variants with lower PI3K\/Akt\/mTOR activity respond more poorly to the combination therapy than to the endocrine therapy alone, associated with inhibition of stromal pS6 and the reparative reaction. In human breast cancer xenografts we confirm that such differential sensitivity to therapy is primarily determined by the level of PI3K\/Akt\/mTOR in tumor cells. We further show that the clinical response of breast cancer patients undergoing neoadjuvant endocrine therapy is associated with the reparative stromal reaction. We conclude that tumor level andlocalization of pS6 are associated with therapeutic response in breast cancer and represent biomarkers to distinguish which tumors will benefit from the incorporation of PI3K\/Akt\/mTOR inhibitors with neoadjuvant endocrine therapy.","palabras_clave":"BREAST CANCER|PI3K\/AKT|STROMA|ENDOCRINE TREATMENT"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19836,"idioma_id":4,"titulo":"Synergistic effects of UVR and simulated stratification on commensalistic phytoplankton?bacteria relationship in two optically contrasting oligotrophic Mediterranean lakes","resumen":"An indirect effect of global warming is the   shallowing epilimnion, causing organisms to be exposed to higher levels   of ultraviolet  (UVR, 280-400 nm) and photosynthetically active radiation (PAR, 400?700   nm), which could affect primary and bacterial  production as well as the commensalistic algal-bacterial relationship.   The combined effects of UVR and reduction in the depth of the  upper mixed layer (UML) were assessed on variables related to the   metabolism of algae and bacteria, during in situ experiments  performed with natural microplanktonic communities from two oligotrophic   lakes with contrasting UVR-transparency (clear  vs. opaque) of southern Spain. The negative UVR effects on epilimnetic   primary production (PP) and on heterotrophic bacterial  production (HBP), intensified by high mean irradiances, were higher in   the UVR-opaque than in the UVR-clear lake, and stronger on the  algae than on the heterotrophic bacterial communities. Under UVR and   high mean irradiance, the algal-bacterial relationship was  strengthened in the UVR-clear lake, where excreted organic carbon (EOC)   rates exceeded the bacterial carbon demand (BCD). This  did not occur in the UVR-opaque lake. The greater UVR damage to algae   and bacteria and the weakening of their commensalistic  interaction found in the UVR-opaque lake indicates that these ecosystems   would be especially vulnerable to stressors related to global  change. Thus, our findings may have important implications for the   carbon cycle in oligotrophic lakes of the Mediterranean region.","palabras_clave":"BACTERIA|PHYTOPLANKTON|FRESHWATER"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19838,"idioma_id":4,"titulo":"Penicillium commune metabolic profile as a promising source of antipathogenic natural products","resumen":"Penicillium is an important genus of ascomycetous fungi in the environment and in food and drug production. This paper aims to investigate statins and antipathogenic natural products from a Penicillium commune environmental isolate. Fractions (F1, F2, F3 and F4) were obtained from an ethyl acetate extract. Direct insertion probe\/electron ionisation\/ion trap detection mass spectrometry (MS and MS\/MS) identified lovastatin (1) in F1, while GC-MS showed that 3-isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (2) was the main constituent of F2 (49.34%). F4 presented 3 (16.38%) as an analogue of 2 and their known structures were similar to that of an autoinducer-signal. F1 produced a significant decrease in the Pseudomonas aeruginosa biofilms, which is the main cause of bacterial pathogenicity. F2 and F4 were effective against Staphylococcus aureus biofilms, but when F2 was associated with oxacillin, it showed an important activity against both bacteria. These novel results suggest that P. commune INTA1 is a new source of promising antipathogenic products.","palabras_clave":"PENICILLIUM COMMUNE METABOLIC PROFILE|DIP\/EI\/ITD MASS SPECTROMETRY (MS AND MS\/MS)|GC-MS ANALYSIS|LOVASTATIN|PYRROLOPYRAZINES|BIOFILMS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19839,"idioma_id":4,"titulo":"TEMPORAL DISSOCIATION BETWEEN SODIUM DEPLETION AND SODIUM APPETITE APPEARANCE: INVOLVEMENT OF INHIBITORY AND STIMULATORY SIGNALS","resumen":"Our aim was to analyze the participation of inhibitory and stimulatory signals in the temporal dissociation between sodium depletion (SD) induced by peritoneal dialysis (PD) and the appearance of sodium appetite (SA), particularly 2. h after PD, when the rats are hypovolemic\/natremic but SA is not evident. We investigated the effects of bilateral injections of the serotonin (5-HT) receptor antagonist, methysergide, into the lateral parabrachial nucleus (LPBN) on hypertonic NaCl and water intake 2. h vs. 24. h after PD. We also studied plasma renin activity (PRA) and aldosterone (ALDO) concentration 2. h vs. 24. h after PD. Additionally, we combined the analysis of brain Fos immunoreactivity (Fos-ir) with the detection of double immunoreactivity in 5HT and oxytocinergic (OT) cells 2. h after PD. Bilateral LPBN injections of methysergide (4. ?g\/200. nl at each site) increased NaCl intake when tested 2. h after PD compared to controls. We found a significant increase in PRA and ALDO concentration after PD but no differences between 2 and 24. h after PD. We also found for the first time a significant increase 2. h after PD in the number of Fos-ir neurons in the brainstem nuclei that have been shown to be involved in the inhibition of SA.In summary, the results show that 5HT-mechanisms in the LPBN modulate sodium intake during the delay of SA when the renin angiotensin aldosterone system (RAAS) is increased. In addition, the activation of brainstem areas previously associated with the satiety phase of SA is in part responsible for the temporal dissociation between SD and behavioral arousal.","palabras_clave":"SODIUM DEPLETION |SEROTONERGIC SYSTEM|TEMPORARY DISSOCIATION |SODIUM APPETITE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19840,"idioma_id":4,"titulo":"Assembly of magnetic nanoparticles at a liquid\/liquid interface. Catalytic effect on ion transfer process","resumen":"The adsorption of cobalt (Co) and cobalt-boron (CoxB) magnetic nanoparticles (NPs) at a liquid\/liquid interface is examined. The Co NPs have a remanence magnetization while the CoxB is completely demagnetized in the absence of an external magnetic field. Cyclic voltammetry experiments reveal that the adsorption of these NPs at the interface shifts the positive potential limit towards lower values showing that a catalytic effect on the ion transfer process is occurring, while electrochemical impedance spectroscopy demonstrates that their mode of self-assembly is directed by their magnetic properties. CoxB NPs form a homogeneous film while Co segregates in macroscopic patches, leaving some areas of the interface uncovered.","palabras_clave":"MAGNETIC NANOPARTICLES|FILMS|SELF-ASSEMBLY|LIQUID\/LIQUID INTERFACES|ELECTROCHEMISTRY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19841,"idioma_id":4,"titulo":"Spatial distribution, feeding and length-mass relationships of Diamphipnopsis samali (Plecoptera, Diamphipnoidae) in a North Patagonia Andean stream, Argentina","resumen":"Some aspects of the biology and ecology (distribution pattern, feeding habits and length-mass relationship) of a population of Diamphipnopsis samali are studied in a first order stream surrounded by exotic forest located in North Patagonia, Chubut province, Argentina. Two samplings were performed during high and low water periods. All information was treated with fixed-effects 2-factor ANOVA models to assess significant differences. Mouth parts analysis of D. samali indicates that it corresponds to an intermediate type between carnivorous and herbivorous-detritivorous type. The guts content shows that the species specially fed on wood and fungal hyphae. No significant difference on the consumed food between sampling periods was found, even though there were significant differences between food content on large and small larvae. Regarding the habitat there was a clear preference for habitats waterfall and log and the difference between run and pool was also significant. There were no significant differences in substrate preference between high and low water periods. This Patagonian endemic species seems to be well adapted to the presence of exotic riparian forest using fallen logs for shelter and food.","palabras_clave":"Habitat use|Larval feeding|Exotic forest"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19842,"idioma_id":4,"titulo":"Temporal dynamic of invertebrate and aquatic plant communities at three intermittent ponds in livestock grazed Patagonian wetlands","resumen":"Ponds are worldwide recognized as biodiversity hotspots, nevertheless in Patagonia are still needed studies that reveal the composition and the status of their communities. This paper analyses the temporal patterns of aquatic invertebrates and assesses the environmental factors that best predict the variation in community structure at three small intermittent ponds, subjected to ranching practices (summer stocking) in the Patagonia steppe. Variables identified as important in structuring community assemblages were related to environmental conditions (rainfall and water temperature), chemical features (conductivity and pH) and biotic factors (macrophyte coverage). During the connected phase only a small number of invertebrate species were present, in contrast to the 11 taxa that were frequent and abundant during isolated period (Eucyclops chilensis, Hyalella curvispina, and Rhionaeschna sp. were the dominant ones). In this sequence the submersed Myriophyllum quitense and Lilaeopsis macloviana played a crucial role offering habitat and food resources. The present study provides valuable information that can contribute to minimize the environmental damage and to develop strategies for the conservation of Patagonian wetlands.","palabras_clave":"INVERTEBRATES|STEPPE|DYNAMICS|TEMPORARY PONDS"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19843,"idioma_id":4,"titulo":"28-mer fragment derived from enterocin CRL35 displays an unexpected bactericidal effect on Listeria cells","resumen":"p { margin-bottom: 0.25cm; line-height: 120%; text-align: justify; }p.ctl { font-size: 10pt; }a:visited { color: rgb(128, 0, 128); }a:link { color: rgb(0, 0, 255); }    Two  shorter peptides derived from enterocin CRL35, a 43-mer bacteriocin,  were synthesized i.e. the N-terminal fragment spanning from  residues 1to 15, and a 28-mer fragment that represents the C-terminal  of enterocin CRL35, the residues 16 to 43. The separate peptides  showed no activity when combined. On one hand, the 28-mer peptide  displayed an unpredicted antimicrobial activity. On the other, 15-mer  peptide had no consistent anti-Listeria effect. The  dissociation constants calculated from experimental data indicated  that all peptides could bind at similar extent to the sensitive  cells. However, transmembrane electrical potential was not dissipated  to the same level by the different peptides; whereas the full-length  and the C-terminal 28-mer fragment induced almost full dissipation,  15-mer fragment produced only a slow and incomplete effect.  Furthermore, a different interaction of each peptide with membranes  was demonstrated based on studies carried out with liposomes, which  led us to conclude that activity was related to structure rather than  to net positive charges. These results open up the possibility of  designing new peptides based on the 28-mer fragment with enhanced  activity, which would represent a promising approach for combating  Listeria and other pathogens.","palabras_clave":"bacteriocins|enterocin CRL35|Listeria"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19844,"idioma_id":4,"titulo":"Obtention of dietary fibre enriched fractions from peach bagasse using ethanol pre-treatment and microwave drying","resumen":"A process involving ethanol pre-treatment and subsequent microwave   drying was proposed to obtain fractions enriched in dietary fibre from   peach bagasse Prunus persica L. The processing conditions   that&nbsp;allow to obtain samples with optimal functional properties involved   the use of 4.6&nbsp;mL of ethanol (96&nbsp;mL\/100&nbsp;mL) per gram of tissue in the   extraction step performed at 20&nbsp;°C for 15&nbsp;min and a temperature of   55.0&nbsp;°C for drying in a microwave equipment working at a maximum power   of 450&nbsp;W. In general, high values were observed for functional   properties evaluated, fact that indicates the potential of the fractions   for being used for technological as well as for nutritional purposes.   Physicochemical and microstructural analysis were carried out for the   product obtained with the optimal process conditions, observing that the   concentration of cell wall material was 80&nbsp;g\/100&nbsp;g dry fraction and the   optimum fraction also contained phenolic compounds.","palabras_clave":"PRUNUS PERSICA|DIETARY FIBRE|RESPONSE SURFACE METHODOLOGY"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19845,"idioma_id":4,"titulo":"Physiological response at different plant development stages in Glycine max exposed to elevated CO2 concentrations and fly ash amended soils","resumen":"Increasing concentrations of carbon dioxide and heavy metals in soils through pollution are serious problems worldwide. In the present study, we investigated the impacts of elevated atmospheric CO2 and fly ash (FA)-amended soil on the physiological response (chlorophyll content, non-structural carbohydrates, oil and total proteins) of soybean [Glycine max (L.) Merrill] at three growth stages (vegetative, reproductive and maturity). An increase in plant growth andbiomass was observed at elevated CO2 and for moderate concentrations of FA in amended soils in all development plant stages. In contrast to these results, a different response pattern was found for the chlorophyll content and non-structural carbohydrates in relation to the developmental stage, showing that even though in the vegetative growth stage the highest concentration of chlorophylls corresponded to elevated CO2 conditions. An opposite result was observed during the grainfilling stage (reduction of chlorophylls of 15 % at ambient CO2 conditions for the treatments 10, 15, and 25 % of FA), which probably is related with the distribution of nutrients at this stage. Regarding to oil and total protein content an increase was observed at elevated CO2 and high concentrations of FA in amended soils. Our findings demonstrate that elevated CO2 and FA-amended soils alter the physiological response of soybean affecting the crop quality.","palabras_clave":"SOYBEAN|FLY ASH-AMENDED SOILS|PLANT PHYSIOLOGY|SEED CHEMICAL COMPOSITION"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19846,"idioma_id":4,"titulo":"Draft Genome Sequence of Geobacillus sp. Isolate T6, a Thermophilic Bacterium Collected from a Thermal Spring in Argentina","resumen":"Geobacillus sp. isolate T6 was collected from a thermal spring in Salta, Argentina. The draft genome sequence (3,767,773 bp) of this isolate is represented by one major scaffold of 3,46 Mbp, a second one of 207 kbp, and 20 scaffolds of <13 kbp. The assembled sequences revealed 3,919 protein-coding genes.","palabras_clave":"GENOME|GEOBACILLUS|THERMOPHILES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19847,"idioma_id":4,"titulo":"First records of Corydoras polystictus (Siluriformes: Callichthyidae: Corydoradinae) from the province of Misiones, Northeast Argentina","resumen":"Corydoras polystictus ha sido reportado para Argentina solo por los registros publicados por Lüling en 1980 y 1982 para el río Gualeguay, un afluente del río Paraná inferior, en la provincia de Entre Ríos. Este autor mencionó que la distribución de esta especie en Argentina estaría vinculada con la cuenca media e inferior del río Paraná. En este trabajo, proveemos los primeros registros de esta especie para la provincia argentina de Misiones en la cuenca del río Paraná.","palabras_clave":"CORYDORAS|ARGENTINA|MISIONES"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19848,"idioma_id":4,"titulo":"Evaluation of the acrosomal status in Lama glama sperm incubated with acrosome reaction inducers","resumen":"The objectives of this study were to evaluate the effect of different acrosome reaction (AR) inducers on viability and acrosomal status in llama spermatozoa, by using the FITC-PNA\/PI technique and evaluate if there is a positive correlation between the FITC-PNA\/PI and the Coomassie blue (CB) staining techniques. After incubating twenty ejaculates in 0.1% collagenase the centrifuged pellets were resuspended in TALP-BSA medium. An aliquot was sonicated to remove the acrosomal content (positive control). The rest of the sample was incubated for 3h at 38 °C with 5% CO2 and 100% humidity.TREATMENTS: Three aliquots were further incubated 1h with one of the following AR inducers: calcium ionophore, ionomycin or progesterone.CONTROLS: One without inducers and the other, incubated with dimethyl sulfoxide (vehicle of the inducing agents). Acrosomes were evaluated at time 0 and after 4h incubation. Calcium ionophore was the most potent agent for inducing the AR (67.2 ± 14.4% live+dead AR sperm) (P CONCLUSIONS: The FITC-PNA\/PI technique simultaneously evaluates viability and acrosomal status in llama spermatozoa and calcium ionophore could be used as a control of AR.","palabras_clave":"LLAMA SPERM|ACROSOME|CALCIUM IONOPHORE|IONOMYCIN|PROGESTERONE"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19849,"idioma_id":5,"titulo":"VARIACION ESTACIONAL DEL ACEITE ESENCIAL Y MORFOANATOMÍA DE Acanthostyles buniifolius (ASTERACEAE).","resumen":"Se estudió la variación estacional de la composición del  aceite esencial (AE) y la morfoanatomía foliar y caulinar de A. buniifolius correspondiente a una población de la localidad de El Mollar, Tucumán, Argentina. El AE mostró predominancia de hidrocarburos monoterpénicos, con sabineno como componente mayoritario. Se describe la anatomía de la especie, especialmente de las estructuras asociadas a la síntesis de AE, a saber: tricomas glandulares pluricelulares y conductos secretores esquizógenos.","palabras_clave":"Acanthostyles buniifolius|aceite esencial|tejidos secretores"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19850,"idioma_id":4,"titulo":"The variation of the fine structure constant: testing the dipole model with thermonuclear supernovae","resumen":"The&nbsp; large-number&nbsp; hypothesis conjectures&nbsp; that&nbsp; fundamental &nbsp; constants&nbsp; may&nbsp; vary.&nbsp;&nbsp; Accordingly,&nbsp; the&nbsp; space-time&nbsp; variation&nbsp; of &nbsp; fundamental constants&nbsp; has been&nbsp; an active&nbsp; subject of&nbsp; research for &nbsp; decades.&nbsp;&nbsp; Recently, using&nbsp; data&nbsp; obtained with&nbsp; large telescopes&nbsp; a &nbsp; phenomenological model&nbsp; in which&nbsp; the fine structure&nbsp; constant might &nbsp; vary spatially has been proposed.&nbsp; We test whether this hypothetical &nbsp; spatial&nbsp; variation&nbsp; of $alpha$,&nbsp; which&nbsp; follows&nbsp; a dipole&nbsp; law,&nbsp; is &nbsp; compatible&nbsp; with&nbsp; the&nbsp; data&nbsp; of&nbsp; distant&nbsp; thermonuclear&nbsp; supernovae. &nbsp; Unlike previous works, in our&nbsp; calculations we consider not only the &nbsp; variation&nbsp; of the&nbsp; luminosity distance&nbsp; when a&nbsp; varying $alpha$&nbsp; is &nbsp; adopted, but&nbsp; we also take&nbsp; into account&nbsp; the variation of&nbsp; the peak &nbsp; luminosity&nbsp; of Type&nbsp; Ia&nbsp; supernovae resulting&nbsp; from&nbsp; a variation&nbsp; of &nbsp; $alpha$.&nbsp; This&nbsp; is done&nbsp; using an empirical&nbsp; relation for&nbsp; the peak &nbsp; bolometric&nbsp; magnitude&nbsp; of&nbsp; thermonuclear supernovae&nbsp; that&nbsp; correctly &nbsp; reproduces the&nbsp; results of detailed numerical&nbsp; simulations.&nbsp; We find &nbsp; that&nbsp; there&nbsp; is&nbsp; no&nbsp;&nbsp; significant&nbsp; difference&nbsp; between&nbsp; the&nbsp; several &nbsp; phenomenological models studied here and&nbsp; the standard one, in which &nbsp; $alpha$ does not vary spatially.&nbsp;&nbsp; We conclude that the present set &nbsp; of&nbsp; data of&nbsp; Type&nbsp; Ia&nbsp; supernovae is&nbsp; not&nbsp; able&nbsp; to distinguish&nbsp; the &nbsp; standard model&nbsp; from the dipole models,&nbsp; and thus cannot be&nbsp; used to &nbsp; discard nor to confirm the proposed spatial variation of $alpha$.","palabras_clave":"quasars:  absorption lines|cosmology: miscellaneous|stars: white dwarfs|supernovae: general"},{"tipo_produccion_id":1,"anio_publica":2015,"producto_id":19851,"idioma_id":4,"titulo":"Antiviral activity of an N-allyl acridone against dengue virus","resumen":"Background: Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespreadcausative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of thispathogen, there are no antiviral drugs or vaccines currently available for treatment or prevention. In a previousscreening assay, we identified a group of N-allyl acridones as effective virus inhibitors. Here, the antiviral activityand mode of action targeted to viral RNA replication of one of the most active DENV-2 inhibitors was furthercharacterized.Results: The compound 10-allyl-7-chloro-9(10H)-acridone, designated 3b, was active to inhibit the in vitroinfection of Vero cells with the four DENV serotypes, with effective concentration 50% (EC50) values in the range12.5-27.1 &#956;M, as determined by virus yield inhibition assays. The compound